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Aliases for FYB2 Gene

Aliases for FYB2 Gene

  • FYN Binding Protein 2 2 3 5
  • Activation-Dependent, Raft-Recruited ADAP-Like Phosphoprotein 2 3
  • C1orf168 3 4
  • ARAP 3 4
  • Chromosome 1 Open Reading Frame 168 2
  • Uncharacterized Protein C1orf168 3
  • RP4-758N20.2 3

External Ids for FYB2 Gene

Previous HGNC Symbols for FYB2 Gene

  • C1orf168

Summaries for FYB2 Gene

GeneCards Summary for FYB2 Gene

FYB2 (FYN Binding Protein 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for FYB2 Gene

  • Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501).

Additional gene information for FYB2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FYB2 Gene

Genomics for FYB2 Gene

Regulatory Elements for FYB2 Gene

Enhancers for FYB2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H056907 1.3 FANTOM5 ENCODE 18.1 -90.3 -90272 4.2 FOXA2 ATF1 ARID4B DMAP1 YY1 TCF12 SP5 ZHX2 MXD4 NCOA1 C8B C8A FYB2 GC01P056889 LOC105378745
GH01H056575 1.7 FANTOM5 ENCODE dbSUPER 7.9 +240.6 240594 6.6 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF121 ZNF143 SP3 REST C8A FYB2 C8B PRKAA2 PLPP3 RPL23AP85 GC01P056539
GH01H057279 1.3 FANTOM5 ENCODE 2.4 -462.0 -461988 4.5 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 FOS ATF7 SP5 C8A C8B FYB2 GC01P057293 GC01P057267
GH01H057006 0.3 FANTOM5 5.5 -187.1 -187122 0.1 FYB2 C8A C8B GC01P057000 LOC105378748
GH01H056815 1.2 Ensembl ENCODE 0.7 +1.8 1760 4.1 FOXA2 ZFP64 ARID4B DMAP1 YY1 ATF7 SP5 ZHX2 JUNB REST FYB2 GC01P056713
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FYB2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FYB2 Gene

Genomic Locations for FYB2 Gene
chr1:56,718,804-56,819,696
(GRCh38/hg38)
Size:
100,893 bases
Orientation:
Minus strand
chr1:57,184,477-57,285,369
(GRCh37/hg19)

Genomic View for FYB2 Gene

Genes around FYB2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FYB2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FYB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYB2 Gene

Proteins for FYB2 Gene

  • Protein details for FYB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWT5-ARAP_HUMAN
    Recommended name:
    Activation-dependent, raft-recruited ADAP-like phosphoprotein
    Protein Accession:
    Q5VWT5
    Secondary Accessions:
    • Q63HM3
    • Q6ZUY6

    Protein attributes for FYB2 Gene

    Size:
    728 amino acids
    Molecular mass:
    82070 Da
    Quaternary structure:
    • Interacts with SKAP1, LCK and FYN. The phosphorylated form interacts with LCP2.

    Alternative splice isoforms for FYB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYB2 Gene

Post-translational modifications for FYB2 Gene

  • Phosphorylation is required for its function in T-cell activation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FYB2 Gene

Domains & Families for FYB2 Gene

Gene Families for FYB2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FYB2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FYB2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FYB2 Gene

Function for FYB2 Gene

Molecular function for FYB2 Gene

UniProtKB/Swiss-Prot Function:
Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501).

Phenotypes From GWAS Catalog for FYB2 Gene

Gene Ontology (GO) - Molecular Function for FYB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 27335501
genes like me logo Genes that share ontologies with FYB2: view

Phenotypes for FYB2 Gene

GenomeRNAi human phenotypes for FYB2:
genes like me logo Genes that share phenotypes with FYB2: view

miRNA for FYB2 Gene

miRTarBase miRNAs that target FYB2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FYB2 Gene

Localization for FYB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYB2 Gene

Membrane raft. Note=Recruited to membrane rafts and immunological synapse after TCR stimulation. {ECO:0000269 PubMed:27335501}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FYB2 gene
Compartment Confidence
plasma membrane 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for FYB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001772 immunological synapse IDA 27335501
GO:0016020 membrane IEA --
GO:0045121 membrane raft IEA,IDA 27335501
genes like me logo Genes that share ontologies with FYB2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FYB2 Gene

Pathways & Interactions for FYB2 Gene

No Data Available

Interacting Proteins for FYB2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000345972%0d%0a9606.ENSP00000220584%0d%0a
Selected Interacting proteins: Q5VWT5-ARAP_HUMAN ENSP00000345972 for FYB2 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FYB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033627 cell adhesion mediated by integrin IMP 27335501
GO:0050852 T cell receptor signaling pathway IMP 27335501
genes like me logo Genes that share ontologies with FYB2: view

No data available for Pathways by source and SIGNOR curated interactions for FYB2 Gene

Drugs & Compounds for FYB2 Gene

No Compound Related Data Available

Transcripts for FYB2 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FYB2 Gene

No ASD Table

Relevant External Links for FYB2 Gene

GeneLoc Exon Structure for
FYB2
ECgene alternative splicing isoforms for
FYB2

Expression for FYB2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FYB2 Gene:

FYB2

mRNA Expression by UniProt/SwissProt for FYB2 Gene:

Q5VWT5-ARAP_HUMAN
Tissue specificity: Expressed in T-cells (at protein level). Widely expressed.

Evidence on tissue expression from TISSUES for FYB2 Gene

  • Nervous system(4.1)

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FYB2 Gene

Orthologs for FYB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FYB2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1H1orf168 33
  • 98.86 (n)
C1orf168 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H1orf168 33
  • 80.49 (n)
C1orf168 34
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700024P16Rik 33 34
  • 72.61 (n)
Fyb2 16
cow
(Bos Taurus)
Mammalia C1orf168 34
  • 61 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1orf168 34
  • 4 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1orf168 34
  • 28 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1orf168 34
  • 25 (a)
OneToOne
Species where no ortholog for FYB2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FYB2 Gene

ENSEMBL:
Gene Tree for FYB2 (if available)
TreeFam:
Gene Tree for FYB2 (if available)

Paralogs for FYB2 Gene

No data available for Paralogs for FYB2 Gene

Variants for FYB2 Gene

Sequence variations from dbSNP and Humsavar for FYB2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000010970 -- 56,788,591(+) GTCAA(G/T)TTCAC intron-variant
rs1000017251 -- 56,758,072(+) CTATG(A/C)CTGGC intron-variant
rs1000037932 -- 56,746,081(+) CTTTA(C/T)TTTTT intron-variant
rs1000055927 -- 56,807,438(+) GTTTT(C/T)GCTTT intron-variant
rs1000066736 -- 56,816,687(+) CTCCT(-/G)CCTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FYB2 Gene

Variant ID Type Subtype PubMed ID
nsv523032 CNV gain 19592680
nsv520726 CNV loss 19592680
nsv478675 CNV novel sequence insertion 20440878
nsv160326 CNV deletion 16902084
nsv1149723 CNV deletion 26484159
nsv1122348 CNV deletion 24896259
nsv1076468 CNV deletion 25765185
esv988788 CNV deletion 20482838
esv7859 CNV loss 19470904
esv3586130 CNV loss 21293372
esv3562438 CNV deletion 23714750
esv3554 CNV loss 18987735
esv3411748 CNV insertion 20981092
esv3345680 CNV insertion 20981092
esv3306159 CNV mobile element insertion 20981092
esv2852457 CNV deletion 24192839
esv2748674 CNV deletion 23290073
esv2663893 CNV deletion 23128226
esv2568213 CNV deletion 19546169
esv2296236 CNV deletion 18987734
esv1167886 CNV deletion 17803354

Variation tolerance for FYB2 Gene

Residual Variation Intolerance Score: 71.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FYB2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FYB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYB2 Gene

Disorders for FYB2 Gene

Relevant External Links for FYB2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FYB2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FYB2

No disorders were found for FYB2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FYB2 Gene

Publications for FYB2 Gene

  1. ARAP, a Novel Adaptor Protein, Is Required for TCR Signaling and Integrin-Mediated Adhesion. (PMID: 27335501) Jung SH … Lee JR (Journal of immunology (Baltimore, Md. : 1950) 2016) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  4. Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels. (PMID: 22843503) Qi Q … Qi L (Human molecular genetics 2012) 3 60
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60

Products for FYB2 Gene

Sources for FYB2 Gene

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