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Aliases for FYB1 Gene

Aliases for FYB1 Gene

  • FYN Binding Protein 1 2 3 5
  • Adhesion And Degranulation Promoting Adaptor Protein 2 4
  • SLP-76-Associated Phosphoprotein 3 4
  • FYN-T-Binding Protein 3 4
  • FYB-120/130 3 4
  • P120/P130 3 4
  • SLAP-130 3 4
  • SLAP130 3 4
  • ADAP 3 4
  • Adhesion And Degranulation-Promoting Adaptor Protein 3
  • FYN-Binding Protein (FYB-120/130) 2
  • FYN Binding Protein 2
  • FYN-Binding Protein 3
  • PRO0823 3
  • THC3 3
  • FYB 3

External Ids for FYB1 Gene

Previous HGNC Symbols for FYB1 Gene

  • FYB

Summaries for FYB1 Gene

Entrez Gene Summary for FYB1 Gene

  • The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for FYB1 Gene

FYB1 (FYN Binding Protein 1) is a Protein Coding gene. Diseases associated with FYB1 include Thrombocytopenia 3. Among its related pathways are TCR signaling (REACTOME) and TCR signaling in naive CD4+ T cells. An important paralog of this gene is PRAM1.

UniProtKB/Swiss-Prot for FYB1 Gene

  • Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.

Gene Wiki entry for FYB1 Gene

Additional gene information for FYB1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FYB1 Gene

Genomics for FYB1 Gene

Regulatory Elements for FYB1 Gene

Enhancers for FYB1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H039173 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.2 +97.1 97142 7 HDAC1 PKNOX1 TBL1XR1 CHAMP1 TCF12 ZNF766 EGR1 ATF7 IKZF2 CEBPB FYB1 RICTOR GOLGA5P1 GC05P039191
GH05H039185 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +79.0 79014 20 HDGF PKNOX1 ATF1 FOXA2 ARNT YBX1 TCF12 ZNF766 GATA2 FOS FYB1 RICTOR C9 DAB2 GC05P039191
GH05H039223 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +50.1 50128 1 HDAC1 CTCF PKNOX1 TAL1 CEBPG RAD21 ZKSCAN1 TCF12 ZNF766 CTBP1 FYB1 GC05P039191
GH05H039157 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +116.2 116150 1 HDAC1 TBP ATF1 ARNT NFRKB ZBTB40 CHAMP1 YY1 TCF12 ZNF766 FYB1 RICTOR DAB2 GOLGA5P1 GC05M039106
GH05H039207 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +62.8 62765 8 CTCF CAVIN1 CEBPB CEBPG REST ZIC2 CEBPA ZBTB33 FYB1 RICTOR OSMR GC05P039191
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FYB1 on UCSC Golden Path with GeneCards custom track

Promoters for FYB1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000179859 -472 401 BRD4 IRF2 MAX ELF1 RELA IKZF1 ETV6 IKZF2 MYC SPI1

Genomic Location for FYB1 Gene

Chromosome:
5
Start:
39,105,236 bp from pter
End:
39,274,528 bp from pter
Size:
169,293 bases
Orientation:
Minus strand

Genomic View for FYB1 Gene

Genes around FYB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FYB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FYB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYB1 Gene

Proteins for FYB1 Gene

  • Protein details for FYB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15117-FYB_HUMAN
    Recommended name:
    FYN-binding protein
    Protein Accession:
    O15117
    Secondary Accessions:
    • A8K2Y8
    • B4DLN2
    • E9PBV9
    • O00359
    • Q9NZI9

    Protein attributes for FYB1 Gene

    Size:
    783 amino acids
    Molecular mass:
    85387 Da
    Quaternary structure:
    • Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN (PubMed:27335501, PubMed:9207119, PubMed:10942756, PubMed:15849195). Interacts with LCP2 (PubMed:27335501, PubMed:9207119, PubMed:10942756). Interacts with SKAP1 (PubMed:27335501, PubMed:9755858, PubMed:9748251, PubMed:9671755, PubMed:10856234, PubMed:15849195, PubMed:16461356). Interacts with SKAP2 (PubMed:9755858, PubMed:9671755). Interacts with FASLG (PubMed:19807924). Interacts with EVL (PubMed:10747096). Interacts with TMEM47 (By similarity). Interacts with LCK (PubMed:27335501).

    Three dimensional structures from OCA and Proteopedia for FYB1 Gene

    Alternative splice isoforms for FYB1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYB1 Gene

Post-translational modifications for FYB1 Gene

  • T-cell receptor ligation leads to increased tyrosine phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for FYB1 (FYB/ADAP/SLAP130)
  • Cell Signaling Technology (CST) Antibodies for FYB1 (SLAP-130)
  • Abcam antibodies for FYB1

No data available for DME Specific Peptides for FYB1 Gene

Domains & Families for FYB1 Gene

Gene Families for FYB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FYB1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FYB1: view

No data available for UniProtKB/Swiss-Prot for FYB1 Gene

Function for FYB1 Gene

Molecular function for FYB1 Gene

UniProtKB/Swiss-Prot Function:
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.

Phenotypes From GWAS Catalog for FYB1 Gene

Gene Ontology (GO) - Molecular Function for FYB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10747096
GO:0005515 protein binding IPI 9207119
GO:0008289 lipid binding IEA --
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with FYB1: view
genes like me logo Genes that share phenotypes with FYB1: view

Human Phenotype Ontology for FYB1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FYB1 Gene

MGI Knock Outs for FYB1:
  • Fyb tm1b(EUCOMM)Hmgu
  • Fyb tm1Gak

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FYB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FYB1 Gene

Localization for FYB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYB1 Gene

Cytoplasm. Nucleus. Cell junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FYB1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FYB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA,IEA --
GO:0015629 actin cytoskeleton IEA,TAS 10747096
genes like me logo Genes that share ontologies with FYB1: view

Pathways & Interactions for FYB1 Gene

genes like me logo Genes that share pathways with FYB1: view

Pathways by source for FYB1 Gene

Gene Ontology (GO) - Biological Process for FYB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 9207119
GO:0006607 NLS-bearing protein import into nucleus TAS 9207119
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 9207119
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FYB1: view

No data available for SIGNOR curated interactions for FYB1 Gene

Drugs & Compounds for FYB1 Gene

(1) Drugs for FYB1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FYB1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FYB1: view

Transcripts for FYB1 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FYB1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FYB1 Gene

No ASD Table

Relevant External Links for FYB1 Gene

GeneLoc Exon Structure for
FYB1
ECgene alternative splicing isoforms for
FYB1

Expression for FYB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of FYB1 Gene:

FYB1

mRNA Expression by UniProt/SwissProt for FYB1 Gene:

O15117-FYB_HUMAN
Tissue specificity: Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.

Evidence on tissue expression from TISSUES for FYB1 Gene

  • Blood(4.6)
  • Nervous system(4.3)
  • Liver(4.1)
  • Lung(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FYB1: view

Primer Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FYB1 Gene

Orthologs for FYB1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FYB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FYB 33
  • 98.36 (n)
dog
(Canis familiaris)
Mammalia FYB 33 34
  • 87.56 (n)
cow
(Bos Taurus)
Mammalia FYB 33 34
  • 85.54 (n)
rat
(Rattus norvegicus)
Mammalia Fyb 33
  • 81.5 (n)
mouse
(Mus musculus)
Mammalia Fyb 33 16 34
  • 81.48 (n)
oppossum
(Monodelphis domestica)
Mammalia FYB 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FYB 34
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves FYB 33 34
  • 64.03 (n)
lizard
(Anolis carolinensis)
Reptilia FYB 34
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fyb 33
  • 56.05 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-147j13.3 33
  • 51.63 (n)
FYB (2 of 2) 34
  • 50 (a)
OneToMany
FYB (1 of 2) 34
  • 33 (a)
OneToMany
Species where no ortholog for FYB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FYB1 Gene

ENSEMBL:
Gene Tree for FYB1 (if available)
TreeFam:
Gene Tree for FYB1 (if available)

Paralogs for FYB1 Gene

Paralogs for FYB1 Gene

genes like me logo Genes that share paralogs with FYB1: view

Variants for FYB1 Gene

Sequence variations from dbSNP and Humsavar for FYB1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000010838 -- 39,252,466(+) CACAC(A/C)CAAAC intron-variant
rs1000080647 -- 39,128,423(+) TTGAC(A/T)TTTAG intron-variant
rs1000091338 -- 39,133,320(+) AAGTA(A/G)TCATC intron-variant
rs1000091827 -- 39,175,504(+) TCTGG(A/G)ACTTA intron-variant
rs1000163903 -- 39,230,662(+) AAAAA(C/G)TCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FYB1 Gene

Variant ID Type Subtype PubMed ID
esv1006514 CNV insertion 20482838
esv2730112 CNV deletion 23290073
esv3397789 CNV insertion 20981092
esv3604776 CNV loss 21293372
esv3604777 CNV gain 21293372
esv3604779 CNV loss 21293372
esv3604780 CNV gain 21293372
esv3604781 CNV loss 21293372
esv3604783 CNV gain 21293372
nsv4804 CNV insertion 18451855
nsv4805 CNV deletion 18451855
nsv529023 CNV loss 19592680
nsv597860 CNV gain 21841781
nsv597871 CNV loss 21841781
nsv950671 CNV duplication 24416366

Variation tolerance for FYB1 Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FYB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FYB1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYB1 Gene

Disorders for FYB1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FYB1 Gene - From: OMIM, ClinVar, and GeneCards

Disorder Aliases PubMed IDs
thrombocytopenia 3
  • thc3
- elite association - COSMIC cancer census association via MalaCards
Search FYB1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FYB_HUMAN
  • Thrombocytopenia 3 (THC3) [MIM:273900]: Thrombocytopenia is defined by a decrease in the number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. THC3 is an autosomal recessive form characterized by onset in infancy. {ECO:0000269 PubMed:25516138, ECO:0000269 PubMed:25876182}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for FYB1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FYB1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FYB1
genes like me logo Genes that share disorders with FYB1: view

No data available for Genatlas for FYB1 Gene

Publications for FYB1 Gene

  1. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain-containing leukocyte protein 76 and modulates interleukin 2 production. (PMID: 9207119) da Silva AJ … Rudd CE (Proceedings of the National Academy of Sciences of the United States of America 1997) 2 3 4 22 60
  2. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. (PMID: 9115214) Musci MA … Koretzky GA (The Journal of biological chemistry 1997) 2 3 4 22 60
  3. Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. (PMID: 16461356) Duke-Cohan JS … Rudd CE (The Journal of biological chemistry 2006) 3 4 22 60
  4. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. (PMID: 10747096) Krause M … Wehland J (The Journal of cell biology 2000) 3 4 22 60
  5. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. (PMID: 9748251) Marie-Cardine A … Koretzky GA (The Journal of biological chemistry 1998) 3 4 22 60

Products for FYB1 Gene

Sources for FYB1 Gene

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