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Aliases for FYB Gene

Aliases for FYB Gene

  • FYN Binding Protein 2 3 5
  • Adhesion And Degranulation Promoting Adaptor Protein 2 4
  • SLP-76-Associated Phosphoprotein 3 4
  • FYN-T-Binding Protein 3 4
  • FYB-120/130 3 4
  • P120/P130 3 4
  • SLAP-130 3 4
  • SLAP130 3 4
  • ADAP 3 4
  • Adhesion And Degranulation-Promoting Adaptor Protein 3
  • FYN-Binding Protein (FYB-120/130) 2
  • FYN-Binding Protein 3
  • PRO0823 3
  • THC3 3

External Ids for FYB Gene

Previous GeneCards Identifiers for FYB Gene

  • GC05M039285
  • GC05M040199
  • GC05M039107
  • GC05M039153
  • GC05M039150
  • GC05M039141
  • GC05M039110

Summaries for FYB Gene

Entrez Gene Summary for FYB Gene

  • The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for FYB Gene

FYB (FYN Binding Protein) is a Protein Coding gene. Diseases associated with FYB include Opiate Dependence. Among its related pathways are Cell junction organization and TCR signaling (REACTOME). GO annotations related to this gene include receptor binding and protein complex binding. An important paralog of this gene is PRAM1.

UniProtKB/Swiss-Prot for FYB Gene

  • Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.

Gene Wiki entry for FYB Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FYB Gene

Genomics for FYB Gene

Regulatory Elements for FYB Gene

Enhancers for FYB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G039173 1.8 FANTOM5 Ensembl ENCODE dbSUPER 23.2 +97.1 97142 7.4 PKNOX1 TCF12 ZNF766 FOS TBX21 SMARCB1 ZNF592 MBD2 CREB3 SMARCA4 FYB RICTOR GOLGA5P1 GC05P039191
GH05G039185 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.3 +79.0 79014 20.7 HDGF FOXA2 PKNOX1 CREB3L1 ARNT YBX1 ZNF766 FOS JUNB SMARCB1 FYB C9 DAB2 RICTOR GC05P039191
GH05G039223 1.6 FANTOM5 Ensembl ENCODE dbSUPER 19.1 +50.1 50128 1.6 CTCF BRD4 HDAC1 PKNOX1 TAL1 RBBP5 CEBPG RAD21 ZKSCAN1 TCF12 FYB GC05P039191
GH05G039157 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.7 +116.2 116150 1.3 ATF1 ARNT YY1 TCF12 ZNF766 GATA2 FOS JUNB KAT8 ZNF592 FYB RICTOR DAB2 GOLGA5P1 GC05M039105
GH05G039207 1.4 FANTOM5 Ensembl ENCODE dbSUPER 19.5 +62.8 62765 8.8 CTCF CAVIN1 CEBPB CEBPG REST ZIC2 CEBPA ZBTB33 FYB RICTOR OSMR GC05P039191
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FYB on UCSC Golden Path with GeneCards custom track

Promoters for FYB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000179859 -472 401 BRD4 CTCF MXI1 IRF2 MAX RELA CBX5 ETV6 IKZF2 TRIM22

Genomic Location for FYB Gene

Chromosome:
5
Start:
39,105,236 bp from pter
End:
39,274,528 bp from pter
Size:
169,293 bases
Orientation:
Minus strand

Genomic View for FYB Gene

Genes around FYB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FYB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FYB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FYB Gene

Proteins for FYB Gene

  • Protein details for FYB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15117-FYB_HUMAN
    Recommended name:
    FYN-binding protein
    Protein Accession:
    O15117
    Secondary Accessions:
    • A8K2Y8
    • B4DLN2
    • E9PBV9
    • O00359
    • Q9NZI9

    Protein attributes for FYB Gene

    Size:
    783 amino acids
    Molecular mass:
    85387 Da
    Quaternary structure:
    • Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN (PubMed:27335501, PubMed:9207119, PubMed:10942756, PubMed:15849195). Interacts with LCP2 (PubMed:27335501, PubMed:9207119, PubMed:10942756). Interacts with SKAP1 (PubMed:27335501, PubMed:9755858, PubMed:9748251, PubMed:9671755, PubMed:10856234, PubMed:15849195, PubMed:16461356). Interacts with SKAP2 (PubMed:9755858, PubMed:9671755). Interacts with FASLG (PubMed:19807924). Interacts with EVL (PubMed:10747096). Interacts with TMEM47 (By similarity). Interacts with LCK (PubMed:27335501).

    Three dimensional structures from OCA and Proteopedia for FYB Gene

    Alternative splice isoforms for FYB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FYB Gene

Post-translational modifications for FYB Gene

  • T-cell receptor ligation leads to increased tyrosine phosphorylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • R&D Systems Antibodies for FYB (FYB/ADAP/SLAP130)
  • Cell Signaling Technology (CST) Antibodies for FYB (SLAP-130)
  • Abcam antibodies for FYB

No data available for DME Specific Peptides for FYB Gene

Domains & Families for FYB Gene

Protein Domains for FYB Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FYB: view

No data available for Gene Families and UniProtKB/Swiss-Prot for FYB Gene

Function for FYB Gene

Molecular function for FYB Gene

UniProtKB/Swiss-Prot Function:
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.

Gene Ontology (GO) - Molecular Function for FYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding TAS 10747096
GO:0005515 protein binding IPI 10409671
GO:0032403 protein complex binding IEA --
genes like me logo Genes that share ontologies with FYB: view
genes like me logo Genes that share phenotypes with FYB: view

Animal Models for FYB Gene

MGI Knock Outs for FYB:
  • Fyb tm1Gak
  • Fyb tm1b(EUCOMM)Hmgu

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FYB Gene

Localization for FYB Gene

Subcellular locations from UniProtKB/Swiss-Prot for FYB Gene

Cytoplasm. Nucleus. Cell junction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FYB gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for FYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IBA,IEA --
GO:0015629 actin cytoskeleton IEA,TAS 10747096
genes like me logo Genes that share ontologies with FYB: view

Pathways & Interactions for FYB Gene

genes like me logo Genes that share pathways with FYB: view

Pathways by source for FYB Gene

Gene Ontology (GO) - Biological Process for FYB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 9207119
GO:0006607 NLS-bearing protein import into nucleus TAS 9207119
GO:0006955 immune response IEA --
GO:0007165 signal transduction TAS 9207119
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with FYB: view

No data available for SIGNOR curated interactions for FYB Gene

Drugs & Compounds for FYB Gene

(1) Drugs for FYB Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for FYB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FYB: view

Transcripts for FYB Gene

Unigene Clusters for FYB Gene

FYN binding protein:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FYB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -
SP5:
SP6: - - -
SP7:

Relevant External Links for FYB Gene

GeneLoc Exon Structure for
FYB
ECgene alternative splicing isoforms for
FYB

Expression for FYB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FYB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FYB Gene

This gene is overexpressed in Whole Blood (x26.0).

Protein differential expression in normal tissues from HIPED for FYB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (21.5), Lymph node (15.6), and Tlymphocyte (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FYB Gene



Protein tissue co-expression partners for FYB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FYB Gene:

FYB

SOURCE GeneReport for Unigene cluster for FYB Gene:

Hs.370503

mRNA Expression by UniProt/SwissProt for FYB Gene:

O15117-FYB_HUMAN
Tissue specificity: Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues.

Evidence on tissue expression from TISSUES for FYB Gene

  • Blood(4.6)
  • Nervous system(4.3)
  • Liver(4.1)
  • Lung(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FYB: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FYB Gene

Orthologs for FYB Gene

This gene was present in the common ancestor of chordates.

Orthologs for FYB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FYB 34
  • 98.36 (n)
dog
(Canis familiaris)
Mammalia FYB 34 35
  • 87.56 (n)
cow
(Bos Taurus)
Mammalia FYB 34 35
  • 85.54 (n)
rat
(Rattus norvegicus)
Mammalia Fyb 34
  • 81.5 (n)
mouse
(Mus musculus)
Mammalia Fyb 34 16 35
  • 81.48 (n)
oppossum
(Monodelphis domestica)
Mammalia FYB 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FYB 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves FYB 34 35
  • 64.03 (n)
lizard
(Anolis carolinensis)
Reptilia FYB 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fyb 34
  • 56.05 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-147j13.3 34
  • 51.63 (n)
FYB (2 of 2) 35
  • 50 (a)
OneToMany
FYB (1 of 2) 35
  • 33 (a)
OneToMany
Species where no ortholog for FYB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FYB Gene

ENSEMBL:
Gene Tree for FYB (if available)
TreeFam:
Gene Tree for FYB (if available)

Paralogs for FYB Gene

Paralogs for FYB Gene

genes like me logo Genes that share paralogs with FYB: view

Variants for FYB Gene

Sequence variations from dbSNP and Humsavar for FYB Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000010838 -- 39,252,466(+) CACAC(A/C)CAAAC intron-variant
rs1000080647 -- 39,128,423(+) TTGAC(A/T)TTTAG intron-variant
rs1000091338 -- 39,133,320(+) AAGTA(A/G)TCATC intron-variant
rs1000091827 -- 39,175,504(+) TCTGG(A/G)ACTTA intron-variant
rs1000163903 -- 39,230,662(+) AAAAA(C/G)TCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FYB Gene

Variant ID Type Subtype PubMed ID
esv1006514 CNV insertion 20482838
esv2730112 CNV deletion 23290073
esv3397789 CNV insertion 20981092
esv3604776 CNV loss 21293372
esv3604777 CNV gain 21293372
esv3604779 CNV loss 21293372
esv3604780 CNV gain 21293372
esv3604781 CNV loss 21293372
esv3604783 CNV gain 21293372
nsv4804 CNV insertion 18451855
nsv4805 CNV deletion 18451855
nsv529023 CNV loss 19592680
nsv597860 CNV gain 21841781
nsv597871 CNV loss 21841781
nsv950671 CNV duplication 24416366

Variation tolerance for FYB Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.37; 63.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FYB Gene

Human Gene Mutation Database (HGMD)
FYB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FYB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FYB Gene

Disorders for FYB Gene

MalaCards: The human disease database

(1) MalaCards diseases for FYB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
opiate dependence
  • opioid type dependence
- elite association - COSMIC cancer census association via MalaCards
Search FYB in MalaCards View complete list of genes associated with diseases

Relevant External Links for FYB

Genetic Association Database (GAD)
FYB
Human Genome Epidemiology (HuGE) Navigator
FYB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FYB
genes like me logo Genes that share disorders with FYB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FYB Gene

Publications for FYB Gene

  1. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. (PMID: 9115214) Musci M.A. … Koretzky G.A. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain- containing leukocyte protein 76 and modulates interleukin 2 production. (PMID: 9207119) da Silva A.J. … Rudd C.E. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 22 64
  3. Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. (PMID: 16461356) Duke-Cohan J.S. … Rudd C.E. (J. Biol. Chem. 2006) 3 4 22 64
  4. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. (PMID: 10747096) Krause M. … Wehland J. (J. Cell Biol. 2000) 3 4 22 64
  5. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (PMID: 9671755) Liu J. … Rudd C.E. (Proc. Natl. Acad. Sci. U.S.A. 1998) 3 4 22 64

Products for FYB Gene

Sources for FYB Gene

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