Aliases for FYB Gene
External Ids for FYB Gene
Previous GeneCards Identifiers for FYB Gene
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for FYB Gene
FYB (FYN Binding Protein) is a Protein Coding gene. Diseases associated with FYB include Chronic Inflammatory Demyelinating Polyneuropathy and Demyelinating Polyneuropathy. Among its related pathways are TCR Signaling (Qiagen) and NF-kappaB Signaling. GO annotations related to this gene include receptor binding and protein complex binding. An important paralog of this gene is PRAM1.
UniProtKB/Swiss-Prot for FYB Gene
Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton.