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FYB Gene

protein-coding   GIFtS: 62
GCID: GC05M039112

FYN Binding Protein

(Previous name: FYN-binding protein (FYB-120/130))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FYN Binding Protein1 2     FYN-Binding Protein (FYB-120/130)1
ADAP2 3     PRO08232
FYB-120/1302 3     Adhesion And Degranulation-Promoting Adaptor Protein2
SLAP-1302 3     FYN-Binding Protein2
FYN-T-Binding Protein2 3     SLAP1303
p120/p1302 3     Adhesion And Degranulation Promoting Adaptor Protein3
SLP-76-Associated Phosphoprotein2 3     

External Ids:    HGNC: 40361   Entrez Gene: 25332   Ensembl: ENSG000000820747   OMIM: 6027315   UniProtKB: O151173   

Export aliases for FYB gene to outside databases

Previous GC identifers: GC05M039285 GC05M040199 GC05M039107 GC05M039153 GC05M039150 GC05M039141 GC05M039110


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FYB Gene:
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The
encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2011)

GeneCards Summary for FYB Gene:
FYB (FYN binding protein) is a protein-coding gene. GO annotations related to this gene include protein complex binding and receptor binding. An important paralog of this gene is PRAM1.

UniProtKB/Swiss-Prot: FYB_HUMAN, O15117
Function: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression
of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a
role in linking T-cell signaling to remodeling of the actin cytoskeleton

Gene Wiki entry for FYB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FYB gene promoter:
         AP-1   NF-kappaB2   ATF-2   IRF-7A   c-Jun   NF-kappaB1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFYB promoter sequence
   Search Chromatin IP Primers for FYB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FYB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.1

FYB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FYB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M039112:  view genomic region     (about GC identifiers)

Start:
39,105,338 bp from pter      End:
39,274,630 bp from pter
Size:
169,293 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FYB_HUMAN, O15117 (See protein sequence)
Recommended Name: FYN-binding protein  
Size: 783 amino acids; 85387 Da
Subunit: Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and
LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2. Interacts with FASLG. Interacts with EVL
3 PDB 3D structures from and Proteopedia for FYB:
1RI9 (3D)        2GTJ (3D)        2GTO (3D)    
Secondary accessions: A8K2Y8 B4DLN2 E9PBV9 O00359 Q9NZI9
Alternative splicing: 3 isoforms:  O15117-1   O15117-2   O15117-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FYB: NX_O15117

Explore proteomics data for FYB at MOPED

Post-translational modifications: 

  • T-cell receptor ligation leads to increased tyrosine phosphorylation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FYB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230022.1  NP_001456.3  NP_955367.1  

    ENSEMBL proteins: 
     ENSP00000316460   ENSP00000426346   ENSP00000427114   ENSP00000425845   ENSP00000426597  
     ENSP00000424919   ENSP00000421988   ENSP00000423888   ENSP00000420989   ENSP00000442840  
    Reactome Protein details: O15117

    FYB Human Recombinant Protein Products:

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    Novus Biologicals FYB Proteins
    Novus Biologicals FYB Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FYB 

     
    antibodies-online proteins for FYB (2 products) 

     
    antibodies-online peptides for FYB

    FYB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FYB
    R&D Systems Antibodies for FYB (SLAP-130)
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    Novus Biologicals FYB Antibodies
    Abcam antibodies for FYB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for FYB
    antibodies-online antibodies for FYB (60 products) 

    FYB Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for FYB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FYB 
    antibodies-online kits for FYB (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry O15117

    ProtoNet protein and cluster: O15117

    1 Blocks protein domain: IPB011511 Variant SH3

    UniProtKB/Swiss-Prot: FYB_HUMAN, O15117
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with FYB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FYB_HUMAN, O15117
    Function: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression
    of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a
    role in linking T-cell signaling to remodeling of the actin cytoskeleton

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10747096
    GO:0005515protein binding IPI10409671
    GO:0032403protein complex binding IEA--
         
    Find genes that share ontologies with FYB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FYB:
     Increased G1 DNA content 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fyb):
     cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with FYB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fybtm1Gak for FYB

       genOway: Develop your customized and physiologically relevant rodent model for FYB

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FYB (see all 14):
    hsa-miR-3671 hsa-miR-206 hsa-miR-16-2* hsa-miR-7-2* hsa-miR-4255 hsa-miR-139-5p hsa-miR-578 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidFYB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FYB

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): FYB (NM_199335)
    Sino Biological Human cDNA Clone for FYB
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FYB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FYB

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FYB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FYB_HUMAN, O15117: Cytoplasm. Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4
    plasma membrane2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0015629actin cytoskeleton TAS10747096

    Find genes that share ontologies with FYB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FYB About   (see all 11)  
    See pathways by source

    SuperPathContained pathways About
    1Cell junction organization
    Cell-Cell communication0.64
    Signal regulatory protein (SIRP) family interactions0.00
    2TCR Signaling (Qiagen)
    TCR Signaling0.68
    ITK and TCR Signaling0.54
    3TCR signaling (REACTOME)
    TCR signaling0.73
    4CREB Pathway
    IP3 Pathway0.68
    5TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64


    Find genes that share SuperPaths with FYB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for FYB
        ITK and TCR Signaling
    IP3 Pathway
    Rap1 Pathway
    TCR Signaling

    1 Cell Signaling Technology (CST) Pathway for FYB
        Lymphocyte Signaling

    2 BioSystems Pathways for FYB
        TCR Signaling Pathway
    TCR signaling in naive CD4+ T cells


    2 Reactome Pathways for FYB
        Signal regulatory protein (SIRP) family interactions
    Generation of second messenger molecules


    1 Kegg Pathway  (Kegg details for FYB):
        Rap1 signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FYB
    Interactions:

        GeneGlobe Interaction Network for FYB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FYB (O151171, 2, 3 ENSP000003164604) via UniProtKB, MINT, STRING, and/or I2D (see all 61)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130941, 2, 3, ENSP000000467944EBI-1753267,EBI-346946 MINT-8027210 MINT-8037013 MINT-15245 MINT-8027889 MINT-8037028 MINT-15244 I2D: score=5 STRING: ENSP00000046794
    ABL1P005192, 3, ENSP000003614234MINT-8110383 I2D: score=3 STRING: ENSP00000361423
    NCK1P163331, 3, ENSP000002889864EBI-1753267,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    FYNP062411, 2, 3, ENSP000003576564EBI-1753267,EBI-515315 MINT-16564 MINT-16566 MINT-8035381 MINT-8111235 MINT-16565 I2D: score=6 STRING: ENSP00000357656
    SKAP1Q86WV11, 2, 3, ENSP000003381714EBI-1753267,EBI-2477305 MINT-7147955 MINT-7147875 MINT-7148011 MINT-7147926 I2D: score=3 STRING: ENSP00000338171
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS9207119
    GO:0006607NLS-bearing protein import into nucleus TAS9207119
    GO:0006955immune response TAS9207119
    GO:0007165signal transduction TAS9207119
    GO:0008150biological_process ND--

    Find genes that share ontologies with FYB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FYB

    2 Novoseek inferred chemical compound relationships for FYB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 50.8 12 9115214 (2), 10026222 (1), 10229084 (1), 11553777 (1) (see all 8)
    phosphotyrosine 39.1 4 16415594 (2)



    Find genes that share compounds with FYB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FYB gene (3 alternative transcripts): 
    NM_001243093.1  NM_001465.4  NM_199335.3  

    Unigene Cluster for FYB:

    FYN binding protein
    Hs.370503  [show with all ESTs]
    Unigene Representative Sequence: NM_001465
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351578(uc003jls.3 uc003jlt.3 uc003jlu.3 uc011cpl.2)
    ENST00000515010 ENST00000505428 ENST00000512982 ENST00000510188 ENST00000512138
    ENST00000506557 ENST00000509072 ENST00000504542 ENST00000503065 ENST00000540520

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FYB (see all 14):
    hsa-miR-3671 hsa-miR-206 hsa-miR-16-2* hsa-miR-7-2* hsa-miR-4255 hsa-miR-139-5p hsa-miR-578 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmidFYB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FYB
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    GenScript: all cDNA clones in your preferred vector (see all 2): FYB (NM_199335)
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      QuantiTect SYBR Green Assays in human, mouse, rat FYB
      QuantiFast Probe-based Assays in human, mouse, rat FYB

    Additional mRNA sequence: 

    AF001862.1 AF116653.2 AF198052.1 AK123918.1 AK290403.1 AK297077.1 BC015933.1 BC017775.1 
    BC058827.1 BC117449.1 BC143645.1 BX647195.1 BX647196.1 U93049.1 

    7 DOTS entries:

    DT.95276447  DT.97796118  DT.310146  DT.40111814  DT.100855751  DT.91744735  DT.100673754 

    Selected AceView cDNA sequences (see all 159):

    AW205097 AW236818 BX100679 U93049 BX644231 BC058827 AF001862 AW135795 
    BX095265 H57377 AA481391 W88451 BM987744 AJ706055 BE501745 AK123918 
    W80388 AI651074 BE538710 BE856347 NM_199335 AA897097 AI064996 BQ072679 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FYB (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -     -     -     -                                                                     
    SP2:              -           -                                                                           
    SP3:              -           -     -                                                                     
    SP4:              -                                                                                       
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for FYB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FYB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATTAATTT
    FYB Expression
    About this image


    FYB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Thymus (Hematopoietic System)    fully expand to see all 3 entries
             Double Negative 3 Thymocytes Thymus
             Thymus
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cardiac Fibroblasts Myocardium
             Atrioventricular Node
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Double Negative 3 Thymocytes Thymus
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
     
     Bone (Muscoskeletal System)
             Bone Marrow
    FYB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FYB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.370503

    UniProtKB/Swiss-Prot: FYB_HUMAN, O15117
    Tissue specificity: Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not
    expressed in B-cells, nor in non-lymphoid tissues

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FYB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FYB gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fyb1 , 5 FYN binding protein1, 5 81.48(n)1
    78.34(a)1
      15 (3.19 cM)5
    238801  NM_011815.51  NP_035945.11 
     65798715 
    chicken
    (Gallus gallus)
    Aves FYB1 FYN binding protein 64.03(n)
    54.08(a)
      427448  NM_001031451.1  NP_001026622.1 
    lizard
    (Anolis carolinensis)
    Reptilia FYB6
    FYN binding protein
    46(a)
    1 ↔ 1
    2(7655561-7692547)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fyb1 FYN binding protein 56.05(n)
    47.86(a)
      100485737  XM_002938194.2  XP_002938240.2 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-147j13.31 si:ch211-147j13.3 51.63(n)
    41.72(a)
      796938  XM_001923558.3  XP_001923593.1 


    ENSEMBL Gene Tree for FYB (if available)
    TreeFam Gene Tree for FYB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FYB gene
    PRAM12  

    Find genes that share paralogs with FYB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FYB (see all 3833)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs174631651,2
    C,F,H--39049804(+) TATCCC/TGTCTT 3 -- ds500125Minor allele frequency- T:0.24NA NS EA CSA WA 2902
    rs1916258541,2
    --39049903(+) CCTCAA/GTATTA 3 -- ds50010--------
    rs1399478171,2
    --39049918(+) AATATA/TTTTAT 3 -- ds50010--------
    rs1439028501,2
    --39049937(+) TTTGAG/TACAGG 3 -- ds50010--------
    rs3585021,2
    C,F,A,H--39049990(-) GAGGTA/CGAGGC 3 -- ds500110Minor allele frequency- C:0.35NA WA CSA EA 372
    rs1845387921,2
    --39050098(+) ACAGGA/GTTTTA 3 -- ds50010--------
    rs1890609181,2
    --39050241(+) AAGGTA/TATCCA 3 -- ut310--------
    rs1442525641,2
    --39050279(+) TCTTAA/GGTGAC 3 -- ut310--------
    rs1824131061,2
    --39050390(+) CTTTCC/TTAGGT 3 -- ut310--------
    rs3585011,2
    C,F,A,H--39050480(-) ATTCAA/GTACAA 3 -- ut3131Minor allele frequency- G:0.22NS EA NA WA CSA 3013

    HapMap Linkage Disequilibrium report for FYB (39105338 - 39274630 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FYB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2730112CNV Deletion23290073
    esv1006514CNV Insertion20482838
    nsv4804CNV Insertion18451855
    nsv4805CNV Loss18451855
    nsv529023CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FYB
    DNA2.0 Custom Variant and Variant Library Synthesis for FYB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602731    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for FYB:
    Heroin dependence     Acquired immunodeficiency syndrome

    Find genes that share disorders with FYB           About GenesLikeMe

    Genetic Association Database (GAD): FYB
    Human Genome Epidemiology (HuGE) Navigator: FYB (8 documents)

    Export disorders for FYB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FYB gene, integrated from 10 sources (see all 66):
    (articles sorted by number of sources associating them with FYB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. (PubMed id 9115214)1, 2, 3, 9 Musci M.A.... Koretzky G.A. (J. Biol. Chem. 1997)
    2. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain- containing leukocyte protein 76 and modulates interleukin 2 production. (PubMed id 9207119)1, 2, 3, 9 da Silva A.J.... Rudd C.E. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    3. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. (PubMed id 9748251)1, 2, 9 Marie-Cardine A.... Koretzky G.A. (J. Biol. Chem. 1998)
    4. Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. (PubMed id 16461356)1, 2, 9 Duke-Cohan J.S.... Rudd C.E. (J. Biol. Chem. 2006)
    5. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. (PubMed id 10747096)1, 2, 9 Krause M....Wehland J. (J. Cell Biol. 2000)
    6. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (PubMed id 9671755)1, 2, 9 Liu J.... Rudd C.E. (Proc. Natl. Acad. Sci. U.S.A. 1998)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M.... Janssen O. (BMC Immunol. 2009)
    9. The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. (PubMed id 16980616)1, 2 Kliche S.... Schraven B. (Mol. Cell. Biol. 2006)
    10. Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. (PubMed id 15849195)1, 2 Huang Y....Wange R.L. (J. Biol. Chem. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2533 HGNC: 4036 AceView: FYB Ensembl:ENSG00000082074 euGenes: HUgn2533
    ECgene: FYB Kegg: 2533 H-InvDB: FYB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FYB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FYB gene:
    Search GeneIP for patents involving FYB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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