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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FYB Gene

protein-coding   GIFtS: 59
GCID: GC05M039112

FYN binding protein

(Previous name: FYN-binding protein (FYB-120/130) )
 Explore 8 diseases affiliated with
FYB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FYB    

Aliases
for FYB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
FYN Binding Protein1 2     FYN-Binding Protein (FYB-120/130)1
FYB-120/1301 2 3     PRO08232
SLAP-1301 2 3     Adhesion And Degranulation-Promoting Adaptor Protein2
ADAP2 3     FYN-Binding Protein2
FYN-T-Binding Protein2 3     SLAP1303
P120/P1301     Adhesion And Degranulation Promoting Adaptor Protein3
SLP-76-Associated Phosphoprotein2 3     

External Ids:    HGNC: 40361   Entrez Gene: 25332   Ensembl: ENSG000000820747   OMIM: 6027315   UniProtKB: O151173   

Export aliases for FYB gene to outside databases

Previous GC identifers: GC05M039285 GC05M040199 GC05M039107 GC05M039153 GC05M039150 GC05M039141 GC05M039110


Summaries
for FYB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FYB:
The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded
protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2011)

UniProtKB/Swiss-Prot: FYB_HUMAN, O15117
Function: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of
interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in
linking T-cell signaling to remodeling of the actin cytoskeleton

Gene Wiki entry for FYB


Genomic Views
for FYB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FYB gene promoter:
         AP-1   NF-kappaB2   ATF-2   IRF-7A   c-Jun   NF-kappaB1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FYB promoter sequence
   Search SABiosciences Chromatin IP Primers for FYB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FYB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13.1   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13.1

FYB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FYB gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M039112:  view genomic region     (about GC identifiers)

Start:
 39,105,338 bp from pter      End:
 39,274,630 bp from pter
Size:
 169,293 bases      Orientation:
 minus strand

Proteins
for FYB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FYB_HUMAN, O15117 (See protein sequence)
Recommended Name: FYN-binding protein  
Size: 783 amino acids; 85387 Da
Subunit: Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3
(By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2. Interacts with FASLG. Interacts with EVL
Subcellular location: Cytoplasm. Nucleus (By similarity)
3 PDB 3D structures from and Proteopedia for FYB:
1RI9 (3D)        2GTJ (3D)        2GTO (3D)    
Secondary accessions: A8K2Y8 E9PBV9 O00359 Q9NZI9
Alternative splicing: 2 isoforms:  O15117-1   O15117-2   

Explore the universe of human proteins at neXtProt for FYB: NX_O15117

Post-translational modifications:

  • T-cell receptor ligation leads to increased tyrosine phosphorylation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15117

    • FYB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001230022.1  NP_001456.3  NP_955367.1  

    ENSEMBL proteins: 
     ENSP00000316460   ENSP00000426346   ENSP00000425845   ENSP00000427114   ENSP00000426597  
     ENSP00000424919   ENSP00000421988   ENSP00000423888   ENSP00000420989   ENSP00000442840  
    Reactome Protein details: O15117
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 2): FYB
    OriGene Protein Over-expression Lysate: FYB
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    Novus Biologicals FYB Proteins
    Novus Biologicals FYB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FYB

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--
    GO:0015629actin cytoskeleton TAS10747096


    FYB for ontologies           About GeneDecksing



    FYB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FYB
    R&D Systems Antibodies for FYB (SLAP-130)
    OriGene Antibodies (see all 4): FYB
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    Abcam antibodies for FYB 
    Uscn Antibodies for FYB
    ThermoFisher Antibodies for FYB

    Assay Products for FYB: 
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FYB

    Protein Domains /
    Families
    for FYB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FYB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001452 SH3_domain
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry O15117

    ProtoNet protein and cluster: O15117

    1 Blocks protein family: IPB011511 Variant SH3

    UniProtKB/Swiss-Prot: FYB_HUMAN, O15117
    Similarity: Contains 1 SH3 domain


    Function
    for FYB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FYB_HUMAN, O15117
    Function: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of
    interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in
    linking T-cell signaling to remodeling of the actin cytoskeleton

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FYB
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FYB (see all 14):
    hsa-miR-3671 hsa-miR-206 hsa-miR-16-2* hsa-miR-7-2* hsa-miR-4255 hsa-miR-139-5p hsa-miR-578 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmid: FYB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FYB (see all 7)
    OriGene shRNA RFP: FYB
    OriGene siRNA: FYB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FYB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FYB

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FYB (see all 4)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FYB 

    Cell Line
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    Search LifeMap BioReagents cell lines for FYB

    In Situ Assay
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005102receptor binding TAS10747096
    GO:0005515protein binding IPI--
    GO:0032403protein complex binding IEA--


    FYB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FYB:
     Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Fybtm1Gak for FYB
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fyb):
     cellular  hematopoietic system  immune system 

    FYB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FYB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Immune System
    		Immune System1.00
    		Adaptive Immune System0.59
    2PKC-Theta Pathway
    		TCR Signaling0.68
    		ITK and TCR Signaling0.54
    3TCR signaling
    		TCR signaling1.00
    4TCR signaling in naive CD4+ T cells
    		TCR signaling in naive CD4+ T cells1.00
    5Signal regulatory protein (SIRP) family interactions
    		Signal regulatory protein (SIRP) family interactions1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    4 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for FYB
        ITK and TCR Signaling
    IP3 Pathway
    Rap1 Pathway
    TCR Signaling

    2 BioSystems Pathways for FYB 
        TCR Signaling Pathway
    TCR signaling in naive CD4+ T cells

    5/6        Reactome Pathways for FYB (see all 6)
        Signal regulatory protein (SIRP) family interactions
    Adaptive Immune System
    Cell-Cell communication
    TCR signaling
    Generation of second messenger molecules



    FYB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FYB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/57 Interacting proteins for FYB (O151171, 2, 3 ENSP000003164604) via UniProtKB, MINT, STRING, and/or I2D (see all 57)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LCP2Q130942, 3, ENSP000000467944MINT-8027210 MINT-8037013 MINT-15245 MINT-8027889 MINT-8037028 MINT-15244 I2D: score=5 STRING: ENSP00000046794
    FYNP062412, 3, ENSP000003576564MINT-16564 MINT-16566 MINT-8035381 MINT-8111235 MINT-16565 I2D: score=6 STRING: ENSP00000357656
    ABL1P005192, 3, ENSP000003614234MINT-8110383 I2D: score=3 STRING: ENSP00000361423
    SKAP1Q86WV11, 2, 3, ENSP000003381714EBI-1753267,EBI-2477305 MINT-7147955 MINT-7147875 MINT-7148011 MINT-7147926 I2D: score=3 STRING: ENSP00000338171
    SH2D1AO608802, 3, ENSP000003601814MINT-56628 MINT-56623 I2D: score=2 STRING: ENSP00000360181
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation TAS9207119
    GO:0006607NLS-bearing substrate import into nucleus TAS9207119
    GO:0006955immune response TAS9207119
    GO:0007165signal transduction TAS9207119
    GO:0007243intracellular protein kinase cascade TAS9207119


    FYB for ontologies           About GeneDecksing



    Drugs & Compounds
    for FYB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FYB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FYB
    2 Novoseek chemical compound relationships for FYB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 50.8 12 9115214 (2), 10026222 (1), 10229084 (1), 11553777 (1) (see all 8)
    phosphotyrosine 39.1 4 16415594 (2)

    Search CenterWatch for drugs/clinical trials and news about FYB 

    Transcripts
    for FYB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FYB gene (3 alternative transcripts): 
    NM_001243093.1  NM_001465.4  NM_199335.3  

    Unigene Cluster for FYB:

    FYN binding protein
    Hs.370503  [show with all ESTs]
    Unigene Representative Sequence: NM_001465
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351578(uc003jls.3 uc003jlt.3 uc003jlu.3 uc011cpl.2)
    ENST00000515010 ENST00000512982 ENST00000505428 ENST00000510188 ENST00000512138
    ENST00000506557 ENST00000509072 ENST00000504542 ENST00000503065 ENST00000540520


    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FYB
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FYB (see all 14):
    hsa-miR-3671 hsa-miR-206 hsa-miR-16-2* hsa-miR-7-2* hsa-miR-4255 hsa-miR-139-5p hsa-miR-578 hsa-miR-1
    SwitchGear 3'UTR luciferase reporter plasmid: FYB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FYB (see all 7)
    OriGene shRNA RFP: FYB
    OriGene siRNA: FYB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FYB
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FYB (NM_199335)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FYB 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FYB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FYB

    Additional cDNA sequence: 

    AF001862.1 AF116653.2 AF198052.1 AK123918.1 AK290403.1 AK297077.1 BC015933.1 BC017775.1 
    BC058827.1 BC117449.1 BC143645.1 BX647195.1 BX647196.1 U93049.1 

    7 DOTS entries:

    DT.95276447  DT.97796118  DT.310146  DT.40111814  DT.100855751  DT.91744735  DT.100673754 

    24/159 AceView cDNA sequences (see all 159):

    AW236818 BE501745 AK123918 W80388 BX100679 AW205097 BC058827 AF001862 
    BX644231 H57377 AW135795 W88451 AA481391 BM987744 U93049 AJ706055 
    BX095265 BQ006479 BI829817 BG759248 BI092197 BM150314 AI357111 CA447735 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FYB (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -     -     -     -                                                                     
    SP2:              -           -                                                                           
    SP3:              -           -     -                                                                     
    SP4:              -                                                                                       
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for FYB

    Expression
    for FYB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FYB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGATTAATTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See FYB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FYB

    SOURCE GeneReport for Unigene cluster: Hs.370503

    UniProtKB/Swiss-Prot: FYB_HUMAN, O15117
    Tissue specificity: Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in
    B-cells, nor in non-lymphoid tissues

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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FYB

    Orthologs
    for FYB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FYB gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fyb1 , 5 FYN binding protein1, 5 81.44(n)1
    78.46(a)1    		   15 (3.19 cM)5
    238801  NM_011815.41  NP_035945.11 
     65798715 
    chicken
    (Gallus gallus)    		 Aves FYB1 FYN binding protein 64.29(n)
    54.06(a)    		   427448  NM_001031451.1  NP_001026622.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FYB6
    		 --
    		 47(a)
    		 1 ↔ 1
    		 2(7655561-7692547)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7969381 FYN-binding protein-like 50.66(n)
    41.73(a)    		   796938  XM_001923558.2  XP_001923593.1 


    ENSEMBL Gene Tree for FYB (if available)
    TreeFam Gene Tree for FYB (if available) 

    Paralogs
    for FYB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FYB gene
    C1orf1682  PRAM12  

    FYB for paralogs           About GeneDecksing



    Genomic Variants
    for FYB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3267 NCBI SNPs in FYB are shown (see all 3267)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs44211281,2
    		H--39058145(+) TTGGAT/CTGCTT 3 -- ut314Minor allele frequency- C:0.00NS EA 418
    rs772580331,2
    		F,--39058244(+) GTAAAA/CTGGAT 3 -- ut311Minor allele frequency- C:0.16WA 118
    rs131728431,2
    		H--39058417(+) TCTAGT/CTATAA 3 -- ut314Minor allele frequency- C:0.00NS EA 406
    rs755273271,2
    		F,--39060615(+) CTTTGT/CGATAT 3 -- int11Minor allele frequency- C:0.07EA 120
    rs743729191,2
    		F,--39060998(+) AAATGC/TGAGCA 3 -- int11Minor allele frequency- T:0.06WA 118
    rs727347381,2
    		C,--39062166(+) TTAGTA/TCTTTT 3 -- int10--------
    rs77038431,2
    		C,F,H,--39062176(+) TTTCAG/AGAAAT 3 -- int15Minor allele frequency- A:0.01NS EA WA 420
    rs413028301,2
    		--39062292(+) CTTTTC/TTCCCT 3 -- int10--------
    rs168681161,2
    		C,F,H,--39063220(+) AAAAGT/GTGGAA 3 -- int110Minor allele frequency- G:0.04NA NS EA WA CSA 680
    rs100663931,2
    		C,F,H,--39063611(+) CAATTA/CATGCA 3 -- int15Minor allele frequency- C:0.07NS EA WA 530

    HapMap Linkage Disequilibrium report for FYB (39105338 - 39274630 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FYB: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FYB

    Disorders / Diseases
    for FYB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FYB for disorders           About GeneDecksing

    OMIM gene information: 602731    OMIM disorders: --

    8 diseases for FYB:    About MalaCards
    chronic inflammatory demyelinating polyneuropathy (cidp)    chronic inflammatory demyelinating polyneuropathy    demyelinating polyneuropathy    heroin dependence
    polyneuropathy    lymphoproliferative syndrome    myeloma    malaria

    2 diseases from the University of Copenhagen DISEASES database for FYB:
    Heroin dependence     Malaria
    Human Genome Epidemiology (HuGE) Navigator: FYB (8 documents)

    Export disorders for FYB gene to outside databases

    Publications
    for FYB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FYB gene, integrated from 9 sources (see all 60):
    (articles sorted by number of sources associating them with FYB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases. (PubMed id 9115214)1, 2, 3, 9 Musci M.A.... Koretzky G.A. (1997)
    2. Cloning of a novel T-cell protein FYB that binds FYN and SH2-domain- containing leukocyte protein 76 and modulates interleukin 2 production. (PubMed id 9207119)1, 2, 3, 9 da Silva A.J.... Rudd C.E. (1997)
    3. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130. (PubMed id 9748251)1, 2, 9 Marie-Cardine A.... Koretzky G.A. (1998)
    4. Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. (PubMed id 16461356)1, 2, 9 Duke-Cohan J.S.... Rudd C.E. (2006)
    5. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. (PubMed id 10747096)1, 2, 9 Krause M....Wehland J. (2000)
    6. FYB (FYN binding protein) serves as a binding partner for lymphoid protein and FYN kinase substrate SKAP55 and a SKAP55-related protein in T cells. (PubMed id 9671755)1, 2, 9 Liu J.... Rudd C.E. (1998)
    7. Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. (PubMed id 19807924)1, 2 Voss M....Janssen O. (2009)
    8. The ADAP/SKAP55 signaling module regulates T-cell receptor-mediated integrin activation through plasma membrane targeting of Rap1. (PubMed id 16980616)1, 2 Kliche S.... Schraven B. (2006)
    9. Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells. (PubMed id 15849195)1, 2 Huang Y....Wange R.L. (2005)
    10. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)

    External Searches for FYB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    Genome Databases showing FYB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2533 HGNC: 4036 AceView: FYB Ensembl:ENSG00000082074 euGenes: HUgn2533
    ECgene: FYB H-InvDB: FYB

    Other Databases showing FYB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FYB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FYB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FYB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FYB gene:
    Search GeneIP for patents involving FYB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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