FXYD7 Gene
protein-coding GIFtS: 46
GCID: GC19P035634
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FXYD domain containing ion transport regulator 7(Previous name: FXYD domain-containing ion transport regulator 7 )
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Aliases
for FXYD7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FXYD Domain Containing Ion Transport Regulator 71 2 | | FXYD Domain-Containing Ion Transport Regulator 71 2 |
Export aliases for FXYD7 gene to outside databasesPrevious GC identifers: GC19P036251 GC19P036083 GC19P040310 GC19P040325 GC19P032142 |
Summaries
for FXYD7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FXYD7:
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. Thisgene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain,beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved humangene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has beenestablished for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on thecytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the propertiesof that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown toinduce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not beencharacterized as a protein. (RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Dec2000)
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Genomic Views
for FXYD7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FXYD7 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FXYD7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXYD7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC cytogenetic band: 19q13.1FXYD7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P035634: view genomic region
(about GC identifiers)
Start:
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35,634,154 bp from pter |
End:
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35,645,205 bp from pter |
Size:
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11,052 bases |
Orientation:
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plus strand |
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Proteins
for FXYD7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FXYD7_HUMAN, P58549 (See
protein sequence)Recommended Name: FXYD domain-containing ion transport regulator 7 Size: 80 amino acids; 8524 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for FXYD7: NX_P58549
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P58549
FXYD7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_071289.1
ENSEMBL proteins: ENSP00000466915 ENSP00000270310 ENSP00000397564 ENSP00000465784 Reactome Protein details: P58549
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FXYD7 for ontologies About GeneDecksing
FXYD7 Antibody Products:
Assay Products for FXYD7: |
Protein
Domains /
Families
for FXYD7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FXYD7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P58549ProtoNet protein and cluster: P58549 1 Blocks protein family: IPB000272 FXYD protein
UniProtKB/Swiss-Prot: FXYD7_HUMAN, P58549Similarity: Belongs to the FXYD family |
Function
for FXYD7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005216 | ion channel activity |
IEA | -- | | GO:0051117 | ATPase binding |
IEA | -- |
FXYD7 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for FXYD7:
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Pathways & Interactions
for FXYD7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | SLC-mediated transmembrane transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for FXYD7
FXYD7 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FXYD7
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FXYD7 (P585493 ENSP000002703104) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0043269 | regulation of ion transport |
IEA | -- |
FXYD7 for ontologies About GeneDecksing
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Drugs & Compounds
for FXYD7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FXYD7
Search CenterWatch for drugs/clinical trials and news about FXYD7
|
Transcripts
for FXYD7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FXYD7 gene: NM_022006.1 Unigene Cluster for FXYD7: FXYD domain containing ion transport regulator 7 Hs.134729 [show with all ESTs]Unigene Representative Sequence: BM5479874 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586063 ENST00000270310(uc002nye.1) ENST00000439441(uc010xsp.1)
ENST00000588265
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD7 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD7
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FXYD7 (NM_022006) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FXYD7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXYD7 |
Additional cDNA sequence: AK057825.1 AK296405.1 BC018619.1 5 DOTS entries: DT.75101773 DT.97834545 DT.121466335 DT.95265212 DT.75122864 24/111 AceView cDNA sequences (see all 111): BM695523 AJ573644 CR598444 BM673498 CR596488 NM_022006 CR617501 BM663606 NM_005031 AI199648 NM_021902 BC018619 AI086449 F33358 BM671752 BQ638990 CD171939 BM662308 AW006222 BQ956193 T84313 BQ445963 AW262746 BM856555
GeneLoc Exon Structure
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Expression
for FXYD7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FXYD7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTTGAGCTT
About this image
See FXYD7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FXYD7
SOURCE GeneReport for Unigene cluster: Hs.134729
SABiosciences Custom PCR Arrays for FXYD7
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FXYD7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FXYD7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXYD7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXYD7 |
Orthologs
for FXYD7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for FXYD7 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Fxyd71 , 5 |
FXYD domain-containing ion transport regulator 71, 5 |
85.42(n)1
86.25(a)1 |
|
7 (19.29 cM)5
577801 NM_022007.11 NP_071290.11
310425155 |
ENSEMBL Gene Tree for FXYD7 (if available)
TreeFam Gene Tree for FXYD7 (if available) |
Paralogs
for FXYD7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FXYD7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FXYD7 (35634154 - 35645205 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FXYD7: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FXYD7 |
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Disorders
/ Diseases
for FXYD7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 FXYD7 for disorders About MalaCards
FXYD7 for disorders About GeneDecksing
OMIM gene information: 606684
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: FXYD7 (3 documents)
Export disorders for FXYD7 gene to outside databases
|
Publications
for FXYD7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FXYD7 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with FXYD7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells. (PubMed id 22535957)1 Moshitzky S....Garty H. (2012)
- Interactome mapping suggests new mechanistic details u nderlying Alzheimer's disease. (PubMed id 21163940)1 Soler-Lopez M....Aloy P. (2011)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- FXYD7 is a brain-specific regulator of Na,K-ATPase alpha 1-beta isozymes. (PubMed id 12093728)1 Beguin P....Geering K. (2002)
- The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PubMed id 10950925)1 Sweadner K.J. and Rael E. (2000)
- Regulation of interferon-induced protein kinase PKR: modulation of P58IPK inhibitory function by a novel protein, P52rIPK. (PubMed id 9447982)1 Gale M.J. Jr.... Katze M.G. (1998)
- FXYD7, mapping of functional sites involved in endoplasmic reticulum export, association with and regulation of Na,K-ATPase. (PubMed id 15133029)9 Crambert G....Geering K. (2004)
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External Searches for FXYD7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FXYD7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FXYD7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FXYD7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FXYD7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FXYD7 gene:
Search GeneIP for patents involving FXYD7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FXYD7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | FXYD7 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FXYD7 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXYD7 |
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