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Aliases for FXYD7 Gene

Aliases for FXYD7 Gene

  • FXYD Domain Containing Ion Transport Regulator 7 2 3
  • FXYD Domain-Containing Ion Transport Regulator 7 2

External Ids for FXYD7 Gene

Previous GeneCards Identifiers for FXYD7 Gene

  • GC19P036251
  • GC19P036083
  • GC19P040310
  • GC19P040325
  • GC19P035634
  • GC19P032142

Summaries for FXYD7 Gene

Entrez Gene Summary for FXYD7 Gene

  • This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,, Dec 2000]

GeneCards Summary for FXYD7 Gene

FXYD7 (FXYD Domain Containing Ion Transport Regulator 7) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ATPase binding and ion channel activity.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD7 Gene

Genomics for FXYD7 Gene

Regulatory Elements for FXYD7 Gene

Transcription factor binding sites by QIAGEN in the FXYD7 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FXYD7 Gene

35,143,250 bp from pter
35,154,302 bp from pter
11,053 bases
Plus strand

Genomic View for FXYD7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FXYD7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD7 Gene

Proteins for FXYD7 Gene

  • Protein details for FXYD7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 7
    Protein Accession:
    Secondary Accessions:

    Protein attributes for FXYD7 Gene

    80 amino acids
    Molecular mass:
    8524 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FXYD7 Gene

Proteomics data for FXYD7 Gene at MOPED

Post-translational modifications for FXYD7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FXYD7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FXYD7 Gene

Domains for FXYD7 Gene

Protein Domains for FXYD7 Gene


Suggested Antigen Peptide Sequences for FXYD7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FXYD family.
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD7: view

No data available for Gene Families for FXYD7 Gene

Function for FXYD7 Gene

Gene Ontology (GO) - Molecular Function for FXYD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0017080 sodium channel regulator activity IBA --
GO:0051117 ATPase binding IEA --
genes like me logo Genes that share ontologies with FXYD7: view

Phenotypes for FXYD7 Gene

genes like me logo Genes that share phenotypes with FXYD7: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FXYD7 Gene

Localization for FXYD7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD7 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for FXYD7 Gene COMPARTMENTS Subcellular localization image for FXYD7 gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FXYD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with FXYD7: view

Pathways for FXYD7 Gene

genes like me logo Genes that share pathways with FXYD7: view

Pathways by source for FXYD7 Gene

Gene Ontology (GO) - Biological Process for FXYD7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0034220 ion transmembrane transport TAS --
GO:0043269 regulation of ion transport --
GO:0055085 transmembrane transport TAS --
GO:2000649 regulation of sodium ion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with FXYD7: view

Transcripts for FXYD7 Gene

mRNA/cDNA for FXYD7 Gene

Unigene Clusters for FXYD7 Gene

FXYD domain containing ion transport regulator 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD7 Gene

No ASD Table

Relevant External Links for FXYD7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD7 Gene

mRNA expression in normal human tissues for FXYD7 Gene

mRNA differential expression in normal tissues according to GTEx for FXYD7 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (7.8), Brain - Cortex (7.7), Brain - Anterior cingulate cortex (BA24) (6.3), Brain - Hippocampus (5.9), Brain - Amygdala (5.8), and Brain - Putamen (basal ganglia) (4.5).

Protein differential expression in normal tissues for FXYD7 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FXYD7 Gene

SOURCE GeneReport for Unigene cluster for FXYD7 Gene Hs.134729

genes like me logo Genes that share expressions with FXYD7: view

Expression partners for FXYD7 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FXYD7 Gene

Orthologs for FXYD7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FXYD7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FXYD7 35
  • 89.47 (n)
  • 90.79 (a)
FXYD7 36
  • 88 (a)
(Mus musculus)
Mammalia Fxyd7 35
  • 85.42 (n)
  • 86.25 (a)
Fxyd7 16
Fxyd7 36
  • 86 (a)
(Rattus norvegicus)
Mammalia Fxyd7 35
  • 86.25 (n)
  • 87.5 (a)
(Monodelphis domestica)
Mammalia FXYD7 36
  • 66 (a)
Species with no ortholog for FXYD7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD7 Gene

Gene Tree for FXYD7 (if available)
Gene Tree for FXYD7 (if available)

Paralogs for FXYD7 Gene

(5) SIMAP similar genes for FXYD7 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FXYD7: view

No data available for Paralogs for FXYD7 Gene

Variants for FXYD7 Gene

Sequence variations from dbSNP and Humsavar for FXYD7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1673006 -- 35,144,327(-) TGGCT(A/G)GATGG intron-variant
rs2085462 -- 35,145,952(-) AAAAA(C/T)ACAAA intron-variant
rs2445824 -- 35,152,631(-) ACTCT(A/C)TCCCC intron-variant
rs2861494 -- 35,149,999(-) gcggg(A/G)gttgc intron-variant
rs4583374 -- 35,146,177(+) ctgtc(A/G)tccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FXYD7 Gene

Variant ID Type Subtype PubMed ID
dgv3849n71 CNV Loss 21882294
nsv911617 CNV Loss 21882294

Relevant External Links for FXYD7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD7 Gene

Disorders for FXYD7 Gene

Relevant External Links for FXYD7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for FXYD7 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for FXYD7 Gene

Publications for FXYD7 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3
  4. FXYD proteins: new tissue- and isoform-specific regulators of Na,K-ATPase. (PMID: 12763855) Geering K. … Crambert G. (Ann. N. Y. Acad. Sci. 2003) 23
  5. FXYD7, mapping of functional sites involved in endoplasmic reticulum export, association with and regulation of Na,K-ATPase. (PMID: 15133029) Crambert G. … Geering K. (J. Biol. Chem. 2004) 23

Products for FXYD7 Gene

Sources for FXYD7 Gene

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