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Aliases for FXYD6-FXYD2 Gene

Aliases for FXYD6-FXYD2 Gene

  • FXYD6-FXYD2 Readthrough 2 3 5

External Ids for FXYD6-FXYD2 Gene

Previous GeneCards Identifiers for FXYD6-FXYD2 Gene

  • GC11U901831
  • GC11M117691

Summaries for FXYD6-FXYD2 Gene

Entrez Gene Summary for FXYD6-FXYD2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes on chromosome 11. One read-through transcript produces a fusion protein that shares sequence identity with each individual gene product, while another read-through transcript encodes a protein that has a distinct C-terminus and only shares sequence identity with the upstream locus (GeneID 53826). [provided by RefSeq, Aug 2011]

GeneCards Summary for FXYD6-FXYD2 Gene

FXYD6-FXYD2 (FXYD6-FXYD2 Readthrough) is a Protein Coding gene. GO annotations related to this gene include ion channel activity. An important paralog of this gene is FXYD1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD6-FXYD2 Gene

Genomics for FXYD6-FXYD2 Gene

Regulatory Elements for FXYD6-FXYD2 Gene

Enhancers for FXYD6-FXYD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FXYD6-FXYD2 on UCSC Golden Path with GeneCards custom track

Promoters for FXYD6-FXYD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FXYD6-FXYD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FXYD6-FXYD2 Gene

117,820,075 bp from pter
117,877,031 bp from pter
56,957 bases
Minus strand

Genomic View for FXYD6-FXYD2 Gene

Genes around FXYD6-FXYD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD6-FXYD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD6-FXYD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD6-FXYD2 Gene

Proteins for FXYD6-FXYD2 Gene

  • Protein details for FXYD6-FXYD2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein FXYD6-FXYD2
    Protein Accession:

    Protein attributes for FXYD6-FXYD2 Gene

    144 amino acids
    Molecular mass:
    16258 Da
    Quaternary structure:
    No Data Available
  • Protein details for FXYD6-FXYD2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein FXYD6-FXYD2
    Protein Accession:

    Protein attributes for FXYD6-FXYD2 Gene

    112 amino acids
    Molecular mass:
    12769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FXYD6-FXYD2 Gene

Proteomics data for FXYD6-FXYD2 Gene at MOPED

Post-translational modifications for FXYD6-FXYD2 Gene

No Post-translational modifications

Other Protein References for FXYD6-FXYD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FXYD6-FXYD2 Gene

Domains & Families for FXYD6-FXYD2 Gene

Protein Domains for FXYD6-FXYD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FXYD6-FXYD2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FXYD6-FXYD2 Gene

Function for FXYD6-FXYD2 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FXYD6-FXYD2 Gene

Localization for FXYD6-FXYD2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FXYD6-FXYD2 Gene

Pathways & Interactions for FXYD6-FXYD2 Gene

SuperPathways for FXYD6-FXYD2 Gene

No Data Available

Interacting Proteins for FXYD6-FXYD2 Gene

Gene Ontology (GO) - Biological Process for FXYD6-FXYD2 Gene


No data available for Pathways by source and SIGNOR curated interactions for FXYD6-FXYD2 Gene

Drugs & Compounds for FXYD6-FXYD2 Gene

No Compound Related Data Available

Transcripts for FXYD6-FXYD2 Gene

mRNA/cDNA for FXYD6-FXYD2 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD6-FXYD2 Gene

No ASD Table

Relevant External Links for FXYD6-FXYD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD6-FXYD2 Gene

mRNA expression in normal human tissues for FXYD6-FXYD2 Gene

genes like me logo Genes that share expression patterns with FXYD6-FXYD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FXYD6-FXYD2 Gene

Orthologs for FXYD6-FXYD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD6-FXYD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FXYD6 36
  • 60 (a)
(Canis familiaris)
Mammalia FXYD6 36
  • 51 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
(Mus musculus)
Mammalia Fxyd6 36
  • 57 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
(Pan troglodytes)
Mammalia FXYD6 36
  • 66 (a)
(Gallus gallus)
Aves FXYD6 36
  • 49 (a)
(Danio rerio)
Actinopterygii fxyd6 36
  • 41 (a)
Species with no ortholog for FXYD6-FXYD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FXYD6-FXYD2 Gene

Gene Tree for FXYD6-FXYD2 (if available)
Gene Tree for FXYD6-FXYD2 (if available)

Paralogs for FXYD6-FXYD2 Gene

Paralogs for FXYD6-FXYD2 Gene

genes like me logo Genes that share paralogs with FXYD6-FXYD2: view

Variants for FXYD6-FXYD2 Gene

Sequence variations from dbSNP and Humsavar for FXYD6-FXYD2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2186666 -- 117,831,390(-) TAGGA(A/C)CTTCT intron-variant
rs2282506 -- 117,835,187(-) GCCTT(C/T)GGTCC intron-variant
rs7130098 -- 117,831,068(+) AGCTA(A/C/G)CACTG intron-variant
rs7130303 -- 117,831,400(+) AAAAA(A/C)TGATG intron-variant
rs11605444 -- 117,836,225(+) CACCC(A/C)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FXYD6-FXYD2 Gene

Variant ID Type Subtype PubMed ID
dgv1317n71 CNV Loss 21882294
nsv517470 CNV Loss 19592680
nsv526267 CNV Loss 19592680

Variation tolerance for FXYD6-FXYD2 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FXYD6-FXYD2 Gene

Disorders for FXYD6-FXYD2 Gene

Relevant External Links for FXYD6-FXYD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FXYD6-FXYD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FXYD6-FXYD2 Gene

Publications for FXYD6-FXYD2 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for FXYD6-FXYD2 Gene

Sources for FXYD6-FXYD2 Gene