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Aliases for FXYD6-FXYD2 Gene

Aliases for FXYD6-FXYD2 Gene

  • FXYD6-FXYD2 Readthrough 2 3

External Ids for FXYD6-FXYD2 Gene

Previous GeneCards Identifiers for FXYD6-FXYD2 Gene

  • GC11U901831
  • GC11M117691

Summaries for FXYD6-FXYD2 Gene

Entrez Gene Summary for FXYD6-FXYD2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes on chromosome 11. One read-through transcript produces a fusion protein that shares sequence identity with each individual gene product, while another read-through transcript encodes a protein that has a distinct C-terminus and only shares sequence identity with the upstream locus (GeneID 53826). [provided by RefSeq, Aug 2011]

GeneCards Summary for FXYD6-FXYD2 Gene

FXYD6-FXYD2 (FXYD6-FXYD2 Readthrough) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include ion channel activity. An important paralog of this gene is FXYD1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD6-FXYD2 Gene

Genomics for FXYD6-FXYD2 Gene

Genomic Location for FXYD6-FXYD2 Gene

Chromosome:
11
Start:
117,820,075 bp from pter
End:
117,877,031 bp from pter
Size:
56,957 bases
Orientation:
Minus strand

Genomic View for FXYD6-FXYD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FXYD6-FXYD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD6-FXYD2 Gene

No data available for Regulatory Elements for FXYD6-FXYD2 Gene

Proteins for FXYD6-FXYD2 Gene

  • Protein details for FXYD6-FXYD2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYL5
    Recommended name:
    Protein FXYD6-FXYD2
    Protein Accession:
    A0A0A6YYL5

    Protein attributes for FXYD6-FXYD2 Gene

    Size:
    112 amino acids
    Molecular mass:
    12769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FXYD6-FXYD2 Gene

Proteomics data for FXYD6-FXYD2 Gene at MOPED

Post-translational modifications for FXYD6-FXYD2 Gene

No Post-translational modifications

Other Protein References for FXYD6-FXYD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FXYD6-FXYD2 Gene

Domains & Families for FXYD6-FXYD2 Gene

Protein Domains for FXYD6-FXYD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FXYD6-FXYD2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FXYD6-FXYD2 Gene

Function for FXYD6-FXYD2 Gene

Gene Ontology (GO) - Molecular Function for FXYD6-FXYD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0017080 sodium channel regulator activity --
genes like me logo Genes that share ontologies with FXYD6-FXYD2: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FXYD6-FXYD2 Gene

Localization for FXYD6-FXYD2 Gene

Gene Ontology (GO) - Cellular Components for FXYD6-FXYD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with FXYD6-FXYD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FXYD6-FXYD2 Gene

Pathways & Interactions for FXYD6-FXYD2 Gene

genes like me logo Genes that share pathways with FXYD6-FXYD2: view

Pathways by source for FXYD6-FXYD2 Gene

Interacting Proteins for FXYD6-FXYD2 Gene

Gene Ontology (GO) - Biological Process for FXYD6-FXYD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0034220 ion transmembrane transport --
GO:2000649 regulation of sodium ion transmembrane transporter activity --
genes like me logo Genes that share ontologies with FXYD6-FXYD2: view

No data available for SIGNOR curated interactions for FXYD6-FXYD2 Gene

Drugs & Compounds for FXYD6-FXYD2 Gene

No Compound Related Data Available

Transcripts for FXYD6-FXYD2 Gene

mRNA/cDNA for FXYD6-FXYD2 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD6-FXYD2 Gene

No ASD Table

Relevant External Links for FXYD6-FXYD2 Gene

GeneLoc Exon Structure for
FXYD6-FXYD2
ECgene alternative splicing isoforms for
FXYD6-FXYD2

Expression for FXYD6-FXYD2 Gene

mRNA expression in normal human tissues for FXYD6-FXYD2 Gene

genes like me logo Genes that share expression patterns with FXYD6-FXYD2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FXYD6-FXYD2 Gene

Orthologs for FXYD6-FXYD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD6-FXYD2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FXYD6 36
  • 60 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FXYD6 36
  • 51 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 57 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fxyd6 36
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 56 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FXYD6 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves FXYD6 36
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fxyd6 36
  • 41 (a)
OneToMany
Species with no ortholog for FXYD6-FXYD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FXYD6-FXYD2 Gene

ENSEMBL:
Gene Tree for FXYD6-FXYD2 (if available)
TreeFam:
Gene Tree for FXYD6-FXYD2 (if available)

Paralogs for FXYD6-FXYD2 Gene

Paralogs for FXYD6-FXYD2 Gene

genes like me logo Genes that share paralogs with FXYD6-FXYD2: view

Variants for FXYD6-FXYD2 Gene

Sequence variations from dbSNP and Humsavar for FXYD6-FXYD2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2186666 -- 117,831,390(-) TAGGA(A/C)CTTCT intron-variant
rs2282506 -- 117,835,187(-) GCCTT(C/T)GGTCC intron-variant
rs7130098 -- 117,831,068(+) AGCTA(A/C/G)CACTG intron-variant
rs7130303 -- 117,831,400(+) AAAAA(A/C)TGATG intron-variant
rs10665705 -- 117,831,701(+) TAGAG(-/AGAG)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FXYD6-FXYD2 Gene

Variant ID Type Subtype PubMed ID
dgv1317n71 CNV Loss 21882294
nsv517470 CNV Loss 19592680
nsv526267 CNV Loss 19592680

Variation tolerance for FXYD6-FXYD2 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FXYD6-FXYD2 Gene

HapMap Linkage Disequilibrium report
FXYD6-FXYD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD6-FXYD2 Gene

Disorders for FXYD6-FXYD2 Gene

Relevant External Links for FXYD6-FXYD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FXYD6-FXYD2
genes like me logo Genes that share disorders with FXYD6-FXYD2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FXYD6-FXYD2 Gene

Publications for FXYD6-FXYD2 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 67

Products for FXYD6-FXYD2 Gene

Sources for FXYD6-FXYD2 Gene

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