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Aliases for FXYD6-FXYD2 Gene

Aliases for FXYD6-FXYD2 Gene

  • FXYD6-FXYD2 Readthrough 2 3 5

External Ids for FXYD6-FXYD2 Gene

Previous GeneCards Identifiers for FXYD6-FXYD2 Gene

  • GC11U901831
  • GC11M117691

Summaries for FXYD6-FXYD2 Gene

Entrez Gene Summary for FXYD6-FXYD2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring FXYD domain-containing ion transport regulator 6 (GeneID 53826) and sodium/potassium-transporting ATPase subunit gamma (GeneID 486) genes on chromosome 11. One read-through transcript produces a fusion protein that shares sequence identity with each individual gene product, while another read-through transcript encodes a protein that has a distinct C-terminus and only shares sequence identity with the upstream locus (GeneID 53826). [provided by RefSeq, Aug 2011]

GeneCards Summary for FXYD6-FXYD2 Gene

FXYD6-FXYD2 (FXYD6-FXYD2 Readthrough) is a Protein Coding gene. GO annotations related to this gene include ion channel activity. An important paralog of this gene is FXYD2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD6-FXYD2 Gene

Genomics for FXYD6-FXYD2 Gene

Regulatory Elements for FXYD6-FXYD2 Gene

Enhancers for FXYD6-FXYD2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G117814 2 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +59.6 59629 6.7 HDGF PKNOX1 FOXA2 ARNT ZFP64 WRNIP1 ARID4B SIN3A YBX1 ZNF2 IL10RA DSCAML1 FXYD2 FXYD6-FXYD2 FXYD6 TMPRSS13 CEP164 TMEM25 JAML GC11P117669
GH11G117949 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11 -74.8 -74761 5.4 HDGF PKNOX1 ARID4B ZNF766 GLIS2 GATA2 ZNF143 FOS ZNF263 REST IL10RA TMPRSS13 CD3E CD3G DSCAML1 ENSG00000254844 FXYD6 FXYD6-FXYD2 ENSG00000254528 FXYD2
GH11G117997 2 FANTOM5 Ensembl ENCODE dbSUPER 9.9 -129.0 -129035 17.5 HDGF FOXA2 PKNOX1 CREB3L1 ARNT WRNIP1 YBX1 ZNF766 ZNF143 ZNF207 IL10RA PCSK7 ENSG00000254528 LOC101929133 LOC653303 FXYD2 TMPRSS13 TMPRSS4 FXYD6 FXYD6-FXYD2
GH11G117906 1.5 Ensembl ENCODE dbSUPER 12.2 -31.9 -31855 4.1 HDGF PKNOX1 ATF1 ARNT ZNF133 TCF12 GTF3C2 GATA2 FOS ZNF263 ARCN1 UBE4A TMPRSS13 FXYD6 FXYD6-FXYD2 DSCAML1 ENSG00000254844 RNF214 ENSG00000254528 FXYD2
GH11G117822 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.1 +52.7 52743 2.9 DRAP1 CTCF TFAP4 JUN ARID4B CEBPG ZIC2 RAD21 CTBP1 POLR2A IL10RA FXYD2 FXYD6 FXYD6-FXYD2 TMPRSS13 DSCAML1 ENSG00000254528 ENSG00000254844
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FXYD6-FXYD2 on UCSC Golden Path with GeneCards custom track

Promoters for FXYD6-FXYD2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000045548 431 801 MXI1 KLF1 ZNF777 SUZ12 RBBP5 HIC1 ZFHX2 POLR2A SCRT2 PRDM10

Genomic Location for FXYD6-FXYD2 Gene

Chromosome:
11
Start:
117,820,075 bp from pter
End:
117,877,031 bp from pter
Size:
56,957 bases
Orientation:
Minus strand

Genomic View for FXYD6-FXYD2 Gene

Genes around FXYD6-FXYD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD6-FXYD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD6-FXYD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD6-FXYD2 Gene

Proteins for FXYD6-FXYD2 Gene

  • Protein details for FXYD6-FXYD2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A087WZ82
    Recommended name:
    FXYD6-FXYD2 readthrough
    Protein Accession:
    A0A087WZ82

    Protein attributes for FXYD6-FXYD2 Gene

    Size:
    144 amino acids
    Molecular mass:
    16258 Da
    Quaternary structure:
    No Data Available
  • Protein details for FXYD6-FXYD2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYL5
    Recommended name:
    Protein FXYD6-FXYD2
    Protein Accession:
    A0A0A6YYL5

    Protein attributes for FXYD6-FXYD2 Gene

    Size:
    112 amino acids
    Molecular mass:
    12769 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FXYD6-FXYD2 Gene

Post-translational modifications for FXYD6-FXYD2 Gene

No Post-translational modifications

Other Protein References for FXYD6-FXYD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FXYD6-FXYD2 Gene

Domains & Families for FXYD6-FXYD2 Gene

Protein Domains for FXYD6-FXYD2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FXYD6-FXYD2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FXYD6-FXYD2 Gene

Function for FXYD6-FXYD2 Gene

Gene Ontology (GO) - Molecular Function for FXYD6-FXYD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017080 sodium channel regulator activity IBA --
genes like me logo Genes that share ontologies with FXYD6-FXYD2: view

Animal Model Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FXYD6-FXYD2 Gene

Localization for FXYD6-FXYD2 Gene

Gene Ontology (GO) - Cellular Components for FXYD6-FXYD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FXYD6-FXYD2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FXYD6-FXYD2 Gene

Pathways & Interactions for FXYD6-FXYD2 Gene

SuperPathways for FXYD6-FXYD2 Gene

No Data Available

Interacting Proteins for FXYD6-FXYD2 Gene

Gene Ontology (GO) - Biological Process for FXYD6-FXYD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0034220 ion transmembrane transport IEA --
GO:2000649 regulation of sodium ion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with FXYD6-FXYD2: view

No data available for Pathways by source and SIGNOR curated interactions for FXYD6-FXYD2 Gene

Transcripts for FXYD6-FXYD2 Gene

mRNA/cDNA for FXYD6-FXYD2 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD6-FXYD2 Gene

No ASD Table

Relevant External Links for FXYD6-FXYD2 Gene

GeneLoc Exon Structure for
FXYD6-FXYD2
ECgene alternative splicing isoforms for
FXYD6-FXYD2

Expression for FXYD6-FXYD2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FXYD6-FXYD2 Gene

genes like me logo Genes that share expression patterns with FXYD6-FXYD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FXYD6-FXYD2 Gene

Orthologs for FXYD6-FXYD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD6-FXYD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FXYD6 35
  • 66 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FXYD6 35
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 57 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fxyd6 35
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FXYD6 35
  • 51 (a)
OneToMany
chicken
(Gallus gallus)
Aves FXYD6 35
  • 49 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fxyd6 35
  • 41 (a)
OneToMany
Species where no ortholog for FXYD6-FXYD2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FXYD6-FXYD2 Gene

ENSEMBL:
Gene Tree for FXYD6-FXYD2 (if available)
TreeFam:
Gene Tree for FXYD6-FXYD2 (if available)

Paralogs for FXYD6-FXYD2 Gene

Paralogs for FXYD6-FXYD2 Gene

genes like me logo Genes that share paralogs with FXYD6-FXYD2: view

Variants for FXYD6-FXYD2 Gene

Sequence variations from dbSNP and Humsavar for FXYD6-FXYD2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs28938168 Pathogenic 117,822,424(-) TCGTG(A/G)GGCTC intron-variant, reference, missense
rs114952534 Likely benign 117,820,301(+) AAGAA(A/G/T)GGGAG utr-variant-3-prime
rs11827585 Likely benign 117,820,660(+) TCCTA(G/T)CATAC intron-variant
rs144519777 Likely benign 117,820,678(+) TACGG(C/T)TCATC reference, synonymous-codon, utr-variant-3-prime
rs146614981 Likely benign 117,822,715(+) GCTGC(C/T)GCCTA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FXYD6-FXYD2 Gene

Variant ID Type Subtype PubMed ID
esv2761714 CNV loss 21179565
esv3627861 CNV loss 21293372
nsv517470 CNV loss 19592680
nsv526267 CNV loss 19592680
nsv556460 CNV gain 21841781

Variation tolerance for FXYD6-FXYD2 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.04; 21.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FXYD6-FXYD2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FXYD6-FXYD2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD6-FXYD2 Gene

Disorders for FXYD6-FXYD2 Gene

Relevant External Links for FXYD6-FXYD2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FXYD6-FXYD2

No disorders were found for FXYD6-FXYD2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FXYD6-FXYD2 Gene

Publications for FXYD6-FXYD2 Gene

  1. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64

Products for FXYD6-FXYD2 Gene

Sources for FXYD6-FXYD2 Gene

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