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Aliases for FXYD6 Gene

Aliases for FXYD6 Gene

  • FXYD Domain Containing Ion Transport Regulator 6 2 3
  • Phosphohippolin 2 3 4
  • FXYD Domain-Containing Ion Transport Regulator 6 2 3

External Ids for FXYD6 Gene

Previous GeneCards Identifiers for FXYD6 Gene

  • GC11M120064
  • GC11M119219
  • GC11M117245
  • GC11M117212
  • GC11M113641

Summaries for FXYD6 Gene

Entrez Gene Summary for FXYD6 Gene

  • This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]

GeneCards Summary for FXYD6 Gene

FXYD6 (FXYD Domain Containing Ion Transport Regulator 6) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ion channel activity. An important paralog of this gene is FXYD1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD6 Gene

Genomics for FXYD6 Gene

Regulatory Elements for FXYD6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FXYD6 Gene

117,820,075 bp from pter
117,877,486 bp from pter
57,412 bases
Minus strand

Genomic View for FXYD6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FXYD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD6 Gene

Proteins for FXYD6 Gene

  • Protein details for FXYD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 6
    Protein Accession:
    Secondary Accessions:
    • A8K0R4
    • J3QLD2
    • Q6FIG9
    • Q6UW52

    Protein attributes for FXYD6 Gene

    95 amino acids
    Molecular mass:
    10542 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ89335.1; Type=Frameshift; Positions=93; Evidence={ECO:0000305};

    Alternative splice isoforms for FXYD6 Gene


neXtProt entry for FXYD6 Gene

Proteomics data for FXYD6 Gene at MOPED

Post-translational modifications for FXYD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FXYD6 Gene

Domains for FXYD6 Gene

Protein Domains for FXYD6 Gene


Suggested Antigen Peptide Sequences for FXYD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H0Q3
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD6: view

No data available for Gene Families for FXYD6 Gene

Function for FXYD6 Gene

Gene Ontology (GO) - Molecular Function for FXYD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005216 ion channel activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0017080 sodium channel regulator activity IBA --
genes like me logo Genes that share ontologies with FXYD6: view

Phenotypes for FXYD6 Gene

MGI mutant phenotypes for FXYD6:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with FXYD6: view

Animal Model Products

CRISPR Products

miRNA for FXYD6 Gene

miRTarBase miRNAs that target FXYD6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FXYD6 Gene

Localization for FXYD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FXYD6 Gene COMPARTMENTS Subcellular localization image for FXYD6 gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for FXYD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with FXYD6: view

Pathways for FXYD6 Gene

genes like me logo Genes that share pathways with FXYD6: view

Pathways by source for FXYD6 Gene

Interacting Proteins for FXYD6 Gene

Gene Ontology (GO) - Biological Process for FXYD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0008150 biological_process ND --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:2000649 regulation of sodium ion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with FXYD6: view

Transcripts for FXYD6 Gene

Unigene Clusters for FXYD6 Gene

FXYD domain containing ion transport regulator 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FXYD6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1: -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - -
SP7: - - - - -
SP8: - - - - -
SP9: -

Relevant External Links for FXYD6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD6 Gene

mRNA expression in normal human tissues for FXYD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD6 Gene

This gene is overexpressed in Brain - Cortex (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FXYD6 Gene

SOURCE GeneReport for Unigene cluster for FXYD6 Gene Hs.744850

genes like me logo Genes that share expressions with FXYD6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FXYD6 Gene

Orthologs for FXYD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FXYD6 35
  • 99.3 (n)
  • 97.89 (a)
FXYD6 36
  • 99 (a)
(Bos Taurus)
Mammalia FXYD6 35
  • 87.02 (n)
  • 91.58 (a)
FXYD6 36
  • 87 (a)
(Canis familiaris)
Mammalia FXYD6 35
  • 87.94 (n)
  • 91.49 (a)
FXYD6 36
  • 76 (a)
(Mus musculus)
Mammalia Fxyd6 35
  • 87.23 (n)
  • 93.62 (a)
Fxyd6 16
Fxyd6 36
  • 85 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Fxyd6 35
  • 88.3 (n)
  • 92.55 (a)
(Gallus gallus)
Aves FXYD6 35
  • 75.44 (n)
  • 76.84 (a)
FXYD6 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fxyd6 35
  • 67.03 (n)
  • 69.89 (a)
(Danio rerio)
Actinopterygii fxyd6 35
  • 67.02 (n)
  • 64.21 (a)
fxyd6 36
  • 61 (a)
wufi25c12 35
Species with no ortholog for FXYD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FXYD6 Gene

Gene Tree for FXYD6 (if available)
Gene Tree for FXYD6 (if available)

Paralogs for FXYD6 Gene

Paralogs for FXYD6 Gene

Selected SIMAP similar genes for FXYD6 Gene using alignment to 4 proteins: Pseudogenes for FXYD6 Gene

genes like me logo Genes that share paralogs with FXYD6: view

Variants for FXYD6 Gene

Sequence variations from dbSNP and Humsavar for FXYD6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs35042242 -- 117,879,104(+) AAAGG(-/C)CCTGA upstream-variant-2KB
rs35999384 -- 117,879,450(+) ATACT(-/C)CCCCA upstream-variant-2KB
rs140916094 -- 117,879,194(+) AAGCA(C/T)TGATG upstream-variant-2KB
rs150188337 -- 117,879,459(+) CACCC(A/G)CCAGA upstream-variant-2KB
rs202074839 -- 117,879,294(+) TGTGT(-/G)GGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FXYD6 Gene

Variant ID Type Subtype PubMed ID
nsv526267 CNV Loss 19592680

Relevant External Links for FXYD6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD6 Gene

Disorders for FXYD6 Gene


  • Schizophrenia 2 (SCZD2) [MIM:603342]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:17357072}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for FXYD6 Gene

Relevant External Links for FXYD6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with FXYD6: view

Publications for FXYD6 Gene

  1. A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia. (PMID: 17357072) Choudhury K. … Gurling H.M.D. (Am. J. Hum. Genet. 2007) 3 4 23 48
  2. A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population. (PMID: 18455306) Ito Y. … Ozaki N. (Neurosci. Lett. 2008) 3 23 48
  3. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PMID: 10950925) Sweadner K.J. … Rael E. (Genomics 2000) 2 3
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4
  5. No association between the FXYD6 gene and schizophrenia in the Chinese Han population. (PMID: 20149392) Zhang J. … He G. (J Psychiatr Res 2010) 3 48

Products for FXYD6 Gene

Sources for FXYD6 Gene

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