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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FXYD6 Gene

protein-coding   GIFtS: 53
GCID: GC11M117741

FXYD Domain Containing Ion Transport Regulator 6

(Previous name: FXYD domain-containing ion transport regulator 6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FXYD Domain Containing Ion Transport Regulator 61 2
FXYD Domain-Containing Ion Transport Regulator 61 2
phosphohippolin1 2
Phosphohippolin3

External Ids:    HGNC: 40301   Entrez Gene: 538262   Ensembl: ENSG000001377267   OMIM: 6066835   UniProtKB: Q9H0Q33   

Export aliases for FXYD6 gene to outside databases

Previous GC identifers: GC11M120064 GC11M119219 GC11M117245 GC11M117212 GC11M113641


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FXYD6 Gene:
This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes
phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript
variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes
10 and X. Read-through transcripts have been observed between this locus and the downstream
sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.(provided by RefSeq, Feb 2011)

GeneCards Summary for FXYD6 Gene: 
FXYD6 (FXYD domain containing ion transport regulator 6) is a protein-coding gene. Diseases associated with FXYD6 include schizophrenia, and psychotic disorder, and among its related super-pathways are Ion channel transport and SLC-mediated transmembrane transport. GO annotations related to this gene include ion channel activity and molecular_function. An important paralog of this gene is FXYD1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FXYD6 gene promoter:
         MAZR   Pax-5   SREBP-1c   FOXD3   MyoD   CUTL1   SREBP-1b   HEN1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFXYD6 promoter sequence
   Search SABiosciences Chromatin IP Primers for FXYD6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXYD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

FXYD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M117741:  view genomic region     (about GC identifiers)

Start:
117,707,691 bp from pter      End:
117,748,201 bp from pter
Size:
40,511 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3 (See protein sequence)
Recommended Name: FXYD domain-containing ion transport regulator 6 precursor  
Size: 95 amino acids; 10542 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAQ89335.1; Type=Frameshift; Positions=93;
Secondary accessions: A8K0R4 J3QLD2 Q6FIG9 Q6UW52
Alternative splicing: 2 isoforms:  Q9H0Q3-1   Q9H0Q3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FXYD6: NX_Q9H0Q3

Explore proteomics data for FXYD6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H0Q3

  • FXYD6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FXYD6 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001158303.1  NP_001158304.1  NP_001158308.1  NP_001158309.1  NP_071286.1  

    ENSEMBL proteins: 
     ENSP00000260282   ENSP00000431446   ENSP00000433312   ENSP00000431427   ENSP00000463160  
     ENSP00000436629   ENSP00000431913   ENSP00000464057   ENSP00000463158   ENSP00000464144  
     ENSP00000444243   ENSP00000442756  
    Reactome Protein details: Q9H0Q3
    Human Recombinant Protein Products for FXYD6: 
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    Novus Biologicals FXYD6 Protein
    Novus Biologicals FXYD6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    FXYD6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000272 Ion-transport_regulator_FXYD

    Graphical View of Domain Structure for InterPro Entry Q9H0Q3

    ProtoNet protein and cluster: Q9H0Q3

    1 Blocks protein domain: IPB000272 FXYD protein

    UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3
    Similarity: Belongs to the FXYD family


    FXYD6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005216ion channel activity IEA--
         
    FXYD6 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fxyd6):
     behavior/neurological 

    FXYD6 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FXYD6 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FXYD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FXYD6 
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    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FXYD6 (see all 12):
    hsa-miR-137 hsa-miR-2110 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1253 hsa-miR-4261 hsa-miR-2355-5p hsa-miR-4279
    SwitchGear 3'UTR luciferase reporter plasmidFXYD6 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD6


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FXYD6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.49
    Ion transport by P-type ATPases0.32
    2SLC-mediated transmembrane transport
    Transmembrane transport of small molecules0.50

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3        Reactome Pathways for FXYD6
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases



    FXYD6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FXYD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/29 Interacting proteins for FXYD6 (Q9H0Q32, 3 ENSP000002602824) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000215641P143732, 3MINT-65440 I2D: score=5 
    ENSG00000229006P143732, 3MINT-65440 I2D: score=5 
    ENSG00000234495P143732, 3MINT-65440 I2D: score=5 
    CCDC90BQ9GZT62, 3MINT-65445 I2D: score=5 
    GDF9O603832, 3MINT-65438 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0008150biological_process ND--
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    FXYD6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FXYD6

    Search CenterWatch for drugs/clinical trials and news about FXYD6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FXYD6 gene (5 alternative transcripts): 
    NM_001164831.2  NM_001164832.2  NM_001164836.2  NM_001164837.2  NM_022003.3  

    Unigene Cluster for FXYD6:

    FXYD domain containing ion transport regulator 6
    Hs.744850  [show with all ESTs]
    Unigene Representative Sequence: AK092198
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260282 ENST00000527717(uc021qra.1) ENST00000526014 ENST00000524656
    ENST00000584394 ENST00000529335 ENST00000583233 ENST00000583660 ENST00000524841
    ENST00000527429 ENST00000530956 ENST00000579486 ENST00000584230 ENST00000534125
    ENST00000527053 ENST00000540359(uc001prp.2 uc001prq.2) ENST00000539526(uc021qqy.1 uc021qqz.1 uc001prr.2 uc001pro.2)

    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FXYD6 (see all 12):
    hsa-miR-137 hsa-miR-2110 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1253 hsa-miR-4261 hsa-miR-2355-5p hsa-miR-4279
    SwitchGear 3'UTR luciferase reporter plasmidFXYD6 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FXYD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXYD6
    Sirion Biotech Customized lentivirus for stable overexpression of FXYD6 
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    OriGene qPCR primer pairs and template standards for FXYD6
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXYD6
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    Additional mRNA sequence: 

    AK055389.1 AK092198.1 AK289629.1 AK290757.1 AK311736.1 AL136699.1 AL832811.1 AY358976.1 
    BC018652.2 BC093040.1 BT006717.1 CR533457.1 

    24/32 DOTS entries (see all 32):

    DT.100885501  DT.95178358  DT.91696981  DT.100885500  DT.100885491  DT.40106468  DT.91769919  DT.100885497 
    DT.100885494  DT.100739618  DT.120713689  DT.95178359  DT.120713848  DT.95198622  DT.100805742  DT.102834806 
    DT.120713751  DT.91769909  DT.100030974  DT.100732894  DT.100770886  DT.120713856  DT.120713884  DT.91769917 

    24/580 AceView cDNA sequences (see all 580):

    BE264820 BX419885 BM695641 CB152911 CR609230 CR617323 AA907232 BP341371 
    BI491845 BG055664 AW160855 BP376407 BX460202 AA211031 CR618485 AW163627 
    AI129212 AW276595 CR611120 BF360668 AA626224 AL536449 CB156271 AA297741 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FXYD6 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
    SP1:                                                                                -                     
    SP2:                                                                                -                     
    SP3:                          -           -                                                               
    SP4:        -     -           -           -                                                               
    SP5:                                                                                -                     


    ECgene alternative splicing isoforms for FXYD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FXYD6 expression in normal human tissues (normalized intensities)      FXYD6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCTGGGA
    FXYD6 Expression
    About this image


    FXYD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/17 selected tissues (see all 17) fully expand
     
     Brain (Nervous System)    fully expand to see all 21 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
             Human Cerebellar Astrocytes   
             Septum   
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Uncategorized (Uncategorized)    fully expand to see all 4 entries
             PureStem Progenitor EN7
     
     Epithelium
             Human Non-Pigment Ciliary Epithelial Cells (HNPCEpiC)   

    See FXYD6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FXYD6

    SOURCE GeneReport for Unigene cluster: Hs.744850
        SABiosciences Custom PCR Arrays for FXYD6
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for FXYD6 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fxyd61 , 5 FXYD domain-containing ion transport regulator 61, 5 87.23(n)1
    93.62(a)1
      9 (24.84 cM)5
    590951  NM_022004.61  NP_071287.11 
     453701855 
    chicken
    (Gallus gallus)
    Aves FXYD61 FXYD domain containing ion transport regulator 6 75.44(n)
    76.84(a)
      770406  NM_001080879.1  NP_001074348.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi25c122 wufi25c12 76.04(n)   333987  BC054135.1 


    ENSEMBL Gene Tree for FXYD6 (if available)
    TreeFam Gene Tree for FXYD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FXYD6 gene
    FXYD12  FXYD6-FXYD22  
    6 SIMAP similar genes for FXYD6 using alignment to 4 protein entries:     FXYD6_HUMAN (see all proteins):
    FXYD6P3    FXYD2    FXYD7    FXYD5    FXYD3    FXYD1

    FXYD6 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for FXYD6
    PGOHUM00000238415 PGOHUM00000238750 PGOHUM00000258438


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/894 SNPs in FXYD6 are shown (see all 894)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407743091,2
    Cuntested1119727452(+) CTTCTC/G/TCTTTT 10 K E mis11EU 1319
    rs107902141,2
    C,F,A,H--113641026(+) TGCTTC/TAGGCT 5 -- ds500111Minor allele frequency- T:0.37NA WA CSA EA 373
    rs1925375381,2
    --113641052(+) TTACAC/GGTATG 5 -- ds50010--------
    rs108921841,2
    C,F,A,H--113641064(+) GTCACC/TACCCC 5 -- ds500118Minor allele frequency- T:0.22NS EA NA WA 1936
    rs1158113611,2
    F--113641190(+) GCTCCA/CAGACA 5 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1460720051,2
    --113641284(+) AATGGA/CGGGAA 5 -- ds50010--------
    rs1843947281,2
    --113641295(+) GGTGCA/GGGACG 5 -- ds50010--------
    rs2011974321,2
    --113641309(+) GGCTG-/AGCAGGAG 5 -- ds50010--------
    rs2004342661,2
    --113641313(+) CAGGA-/GGAGAG 5 -- ds50010--------
    rs1429910351,2
    C--113641387(+) CTGAC-/GGGGCT 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for FXYD6 (117707691 - 117748201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FXYD6:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv526267CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606683    OMIM disorders: --

    UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3
  • Schizophrenia 2 (SCZD2) [MIM:603342]: A complex, multifactorial psychotic disorder or group of disorders
    characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g.
    inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries,
    withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it
    is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild
    impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive
    function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are
    often given the diagnosis of schizoaffective disorder. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry

  • 7 diseases for FXYD6:    About MalaCards
    schizophrenia    psychotic disorder    schizoaffective disorder    mood disorder
    dementia    bipolar disorder    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FXYD6:
    Schizophrenia

    FXYD6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): FXYD6
    Human Genome Epidemiology (HuGE) Navigator: FXYD6 (5 documents)

    Export disorders for FXYD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FXYD6 gene, integrated from 9 sources (see all 26):
    (articles sorted by number of sources associating them with FXYD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia. (PubMed id 17357072)1, 2, 4, 9 Choudhury K....Gurling H.M.D. (2007)
    2. A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population. (PubMed id 18455306)1, 4, 9 Ito Y....Ozaki N. (2008)
    3. A novel replicated association between FXYD6 gene and schizophrenia. (PubMed id 21216238)1, 4 Zhong N....Ma J. (2011)
    4. No association between the FXYD6 gene and schizophren ia in the Chinese Han population. (PubMed id 20149392)1, 4 Zhang J....He G. (2010)
    5. Failure to confirm genetic association of the FXYD6 g ene with schizophrenia: the Japanese population and meta-analysis. (PubMed id 20468077)1, 4 Iwata Y....Yoshikawa T. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    10. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PubMed id 10950925)1, 3 Sweadner K.J. and Rael E. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53826 HGNC: 4030 AceView: FXYD6 Ensembl:ENSG00000137726 euGenes: HUgn53826
    ECgene: FXYD6 H-InvDB: FXYD6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FXYD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FXYD6 gene:
    Search GeneIP for patents involving FXYD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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