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Aliases for FXYD6 Gene

Aliases for FXYD6 Gene

  • FXYD Domain Containing Ion Transport Regulator 6 2 3 5
  • Phosphohippolin 2 3 4
  • FXYD Domain-Containing Ion Transport Regulator 6 2

External Ids for FXYD6 Gene

Previous GeneCards Identifiers for FXYD6 Gene

  • GC11M120064
  • GC11M119219
  • GC11M117741
  • GC11M117245
  • GC11M117212
  • GC11M113641

Summaries for FXYD6 Gene

Entrez Gene Summary for FXYD6 Gene

  • This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X. Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.[provided by RefSeq, Feb 2011]

GeneCards Summary for FXYD6 Gene

FXYD6 (FXYD Domain Containing Ion Transport Regulator 6) is a Protein Coding gene. Diseases associated with FXYD6 include psychotic disorder and schizophrenia. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Cardiac conduction. GO annotations related to this gene include ion channel activity and sodium channel regulator activity. An important paralog of this gene is FXYD1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD6 Gene

Genomics for FXYD6 Gene

Regulatory Elements for FXYD6 Gene

Promoters for FXYD6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FXYD6 on UCSC Golden Path with GeneCards custom track

Genomic Location for FXYD6 Gene

Chromosome:
11
Start:
117,836,976 bp from pter
End:
117,877,486 bp from pter
Size:
40,511 bases
Orientation:
Minus strand

Genomic View for FXYD6 Gene

Genes around FXYD6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD6 Gene

Proteins for FXYD6 Gene

  • Protein details for FXYD6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0Q3-FXYD6_HUMAN
    Recommended name:
    FXYD domain-containing ion transport regulator 6
    Protein Accession:
    Q9H0Q3
    Secondary Accessions:
    • A8K0R4
    • J3QLD2
    • Q6FIG9
    • Q6UW52

    Protein attributes for FXYD6 Gene

    Size:
    95 amino acids
    Molecular mass:
    10542 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ89335.1; Type=Frameshift; Positions=93; Evidence={ECO:0000305};

    Alternative splice isoforms for FXYD6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FXYD6 Gene

Proteomics data for FXYD6 Gene at MOPED

Post-translational modifications for FXYD6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FXYD6 Gene

Domains & Families for FXYD6 Gene

Protein Domains for FXYD6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FXYD6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H0Q3

UniProtKB/Swiss-Prot:

FXYD6_HUMAN :
  • Belongs to the FXYD family.
Family:
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD6: view

No data available for Gene Families for FXYD6 Gene

Function for FXYD6 Gene

Gene Ontology (GO) - Molecular Function for FXYD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FXYD6: view

Phenotypes for FXYD6 Gene

genes like me logo Genes that share phenotypes with FXYD6: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FXYD6 Gene

Localization for FXYD6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD6 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FXYD6 Gene COMPARTMENTS Subcellular localization image for FXYD6 gene
Compartment Confidence
plasma membrane 5
cytosol 2
extracellular 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for FXYD6 Gene

Pathways & Interactions for FXYD6 Gene

genes like me logo Genes that share pathways with FXYD6: view

Interacting Proteins for FXYD6 Gene

Gene Ontology (GO) - Biological Process for FXYD6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport TAS --
GO:1903779 regulation of cardiac conduction TAS --
genes like me logo Genes that share ontologies with FXYD6: view

No data available for SIGNOR curated interactions for FXYD6 Gene

Drugs & Compounds for FXYD6 Gene

No Compound Related Data Available

Transcripts for FXYD6 Gene

Unigene Clusters for FXYD6 Gene

FXYD domain containing ion transport regulator 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
SP1: -
SP2: -
SP3: - -
SP4: - - - -
SP5: -
SP6: - - - -
SP7: - - - - -
SP8: - - - - -
SP9: -
SP10:

Relevant External Links for FXYD6 Gene

GeneLoc Exon Structure for
FXYD6
ECgene alternative splicing isoforms for
FXYD6

Expression for FXYD6 Gene

mRNA expression in normal human tissues for FXYD6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD6 Gene

This gene is overexpressed in Brain - Cortex (x4.0).

Protein differential expression in normal tissues from HIPED for FXYD6 Gene

This gene is overexpressed in Brain (36.9), Frontal cortex (17.5), and Fetal Brain (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FXYD6 Gene



SOURCE GeneReport for Unigene cluster for FXYD6 Gene Hs.744850

genes like me logo Genes that share expression patterns with FXYD6: view

Protein tissue co-expression partners for FXYD6 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FXYD6 Gene

Orthologs for FXYD6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FXYD6 36
  • 99 (a)
OneToMany
FXYD6 35
  • 99.3 (n)
  • 97.89 (a)
cow
(Bos Taurus)
Mammalia FXYD6 36
  • 87 (a)
OneToMany
FXYD6 35
  • 87.02 (n)
  • 91.58 (a)
dog
(Canis familiaris)
Mammalia FXYD6 35
  • 87.94 (n)
  • 91.49 (a)
FXYD6 36
  • 76 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Fxyd6 16
Fxyd6 36
  • 85 (a)
OneToMany
Fxyd6 35
  • 87.23 (n)
  • 93.62 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 81 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Fxyd6 35
  • 88.3 (n)
  • 92.55 (a)
chicken
(Gallus gallus)
Aves FXYD6 35
  • 75.44 (n)
  • 76.84 (a)
FXYD6 36
  • 75 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fxyd6 35
  • 67.03 (n)
  • 69.89 (a)
zebrafish
(Danio rerio)
Actinopterygii fxyd6 36
  • 61 (a)
OneToMany
fxyd6 35
  • 67.02 (n)
  • 64.21 (a)
wufi25c12 35
Species with no ortholog for FXYD6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FXYD6 Gene

ENSEMBL:
Gene Tree for FXYD6 (if available)
TreeFam:
Gene Tree for FXYD6 (if available)

Paralogs for FXYD6 Gene

Paralogs for FXYD6 Gene

(6) SIMAP similar genes for FXYD6 Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for FXYD6 Gene

genes like me logo Genes that share paralogs with FXYD6: view

Variants for FXYD6 Gene

Sequence variations from dbSNP and Humsavar for FXYD6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs35042242 -- 117,879,104(+) AAAGG(-/C)CCTGA upstream-variant-2KB
rs35999384 -- 117,879,450(+) ATACT(-/C)CCCCA upstream-variant-2KB
rs140916094 -- 117,879,194(+) AAGCA(C/T)TGATG upstream-variant-2KB
rs150188337 -- 117,879,459(+) CACCC(A/G)CCAGA upstream-variant-2KB
rs369591893 -- 117,879,141(+) GCCAG(A/G)GTGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FXYD6 Gene

Variant ID Type Subtype PubMed ID
nsv526267 CNV Loss 19592680

Variation tolerance for FXYD6 Gene

Residual Variation Intolerance Score: 66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.05; 1.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FXYD6 Gene

HapMap Linkage Disequilibrium report
FXYD6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD6 Gene

Disorders for FXYD6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FXYD6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
psychotic disorder
  • mental or behavioural disorder
schizophrenia
  • schizophrenia 12
- elite association - COSMIC cancer census association via MalaCards
Search FXYD6 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FXYD6_HUMAN
  • Schizophrenia 2 (SCZD2) [MIM:603342]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:17357072}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for FXYD6

Genetic Association Database (GAD)
FXYD6
Human Genome Epidemiology (HuGE) Navigator
FXYD6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FXYD6
genes like me logo Genes that share disorders with FXYD6: view

No data available for Genatlas for FXYD6 Gene

Publications for FXYD6 Gene

  1. A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia. (PMID: 17357072) Choudhury K. … Gurling H.M.D. (Am. J. Hum. Genet. 2007) 3 4 23 48 67
  2. A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population. (PMID: 18455306) Ito Y. … Ozaki N. (Neurosci. Lett. 2008) 3 23
  3. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PMID: 10950925) Sweadner K.J. … Rael E. (Genomics 2000) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. FXYD6: a novel therapeutic target toward hepatocellular carcinoma. (PMID: 24715268) Gao Q. … Yan X. (Protein Cell 2014) 3

Products for FXYD6 Gene

Sources for FXYD6 Gene

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