Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FXYD6 Gene

protein-coding   GIFtS: 51
GCID: GC11M117741

FXYD Domain Containing Ion Transport Regulator 6

(Previous name: FXYD domain-containing ion transport regulator 6)
  Search for FXYD6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
FXYD Domain Containing Ion Transport Regulator 61 2
FXYD Domain-Containing Ion Transport Regulator 61 2
phosphohippolin1 2
Phosphohippolin3

External Ids:    HGNC: 40301   Entrez Gene: 538262   Ensembl: ENSG000001377267   OMIM: 6066835   UniProtKB: Q9H0Q33   
ORGUL members:         

Export aliases for FXYD6 gene to outside databases

Previous GC identifers: GC11M120064 GC11M119219 GC11M117245 GC11M117212 GC11M113641


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FXYD6 Gene:
This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes
phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript
variants encoding the same protein have been described. Related pseudogenes have been identified on chromosomes
10 and X. Read-through transcripts have been observed between this locus and the downstream
sodium/potassium-transporting ATPase subunit gamma (FXYD2, GeneID 486) locus.(provided by RefSeq, Feb 2011)

GeneCards Summary for FXYD6 Gene:
FXYD6 (FXYD domain containing ion transport regulator 6) is a protein-coding gene. GO annotations related to this gene include ion channel activity. An important paralog of this gene is FXYD1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the FXYD6 gene promoter:
         MAZR   Pax-5   SREBP-1c   FOXD3   MyoD   CUTL1   SREBP-1b   HEN1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFXYD6 promoter sequence
   Search Chromatin IP Primers for FXYD6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FXYD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

FXYD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M117741:  view genomic region     (about GC identifiers)

Start:
117,707,691 bp from pter      End:
117,748,201 bp from pter
Size:
40,511 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3 (See protein sequence)
Recommended Name: FXYD domain-containing ion transport regulator 6 precursor  
Size: 95 amino acids; 10542 Da
Sequence caution: Sequence=AAQ89335.1; Type=Frameshift; Positions=93;
Secondary accessions: A8K0R4 J3QLD2 Q6FIG9 Q6UW52
Alternative splicing: 2 isoforms:  Q9H0Q3-1   Q9H0Q3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FXYD6: NX_Q9H0Q3

Explore proteomics data for FXYD6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FXYD6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001158303.1  NP_001158304.1  NP_001158308.1  NP_001158309.1  NP_071286.1  

    ENSEMBL proteins: 
     ENSP00000260282   ENSP00000431446   ENSP00000433312   ENSP00000431427   ENSP00000463160  
     ENSP00000436629   ENSP00000431913   ENSP00000464057   ENSP00000463158   ENSP00000464144  
     ENSP00000444243   ENSP00000442756  
    Reactome Protein details: Q9H0Q3

    FXYD6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for FXYD6
    OriGene Protein Over-expression Lysate for FXYD6
    OriGene MassSpec for FXYD6
    OriGene Custom Protein Services for FXYD6
    GenScript Custom Purified and Recombinant Proteins Services for FXYD6
    Novus Biologicals FXYD6 Protein
    Novus Biologicals FXYD6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FXYD6 

    FXYD6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for FXYD6
    Novus Biologicals FXYD6 Antibody
    Abcam antibodies for FXYD6
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for FXYD6
    Search LSBio for Antibodies for FXYD6

    FXYD6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FXYD6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FXYD6
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FXYD6 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR000272 Ion-transport_regulator_FXYD

    Graphical View of Domain Structure for InterPro Entry Q9H0Q3

    ProtoNet protein and cluster: Q9H0Q3

    1 Blocks protein domain: IPB000272 FXYD protein

    UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3
    Similarity: Belongs to the FXYD family


    Find genes that share domains with FXYD6           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005216ion channel activity IEA--
         
    Find genes that share ontologies with FXYD6           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Fxyd6):
     behavior/neurological 

    Find genes that share phenotypes with FXYD6           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FXYD6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FXYD6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FXYD6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FXYD6

    miRNA
    Products:
        
    miRTarBase miRNAs that target FXYD6:
    hsa-mir-181a-5p (MIRT025043)

    Block miRNA regulation of human, mouse, rat FXYD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FXYD6 (see all 12):
    hsa-miR-137 hsa-miR-2110 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1253 hsa-miR-4261 hsa-miR-2355-5p hsa-miR-4279
    SwitchGear 3'UTR luciferase reporter plasmidFXYD6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FXYD6
    Predesigned siRNA for gene silencing in human, mouse, rat FXYD6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FXYD6

    Clone
    Products:
         
    OriGene clones in human, mouse for FXYD6 (see all 31)
    OriGene ORF clones in mouse, rat for FXYD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): FXYD6 (NM_022003)
    Sino Biological Human cDNA Clone for FXYD6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FXYD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXYD6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FXYD6
    Browse ESI BIO Cell Lines and PureStem Progenitors for FXYD6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FXYD6_HUMAN, Q9H0Q3: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    extracellular2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016020membrane ----
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with FXYD6           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FXYD6 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Ion transport by P-type ATPases
    Ion transport by P-type ATPases


    Find genes that share SuperPaths with FXYD6           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for FXYD6
        Ion transport by P-type ATPases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FXYD6
    Interactions:

        Search GeneGlobe Interaction Network for FXYD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FXYD6 (Q9H0Q32, 3 ENSP000002602824) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000215641P143732, 3MINT-65440 I2D: score=5 
    ENSG00000229006P143732, 3MINT-65440 I2D: score=5 
    ENSG00000234495P143732, 3MINT-65440 I2D: score=5 
    CCDC90BQ9GZT62, 3MINT-65445 I2D: score=5 
    GDF9O603832, 3MINT-65438 I2D: score=5 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0008150biological_process ND--
    GO:0034220ion transmembrane transport TAS--
    GO:0055085transmembrane transport TAS--

    Find genes that share ontologies with FXYD6           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FXYD6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FXYD6 gene (5 alternative transcripts): 
    NM_001164831.2  NM_001164832.2  NM_001164836.2  NM_001164837.2  NM_022003.3  

    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260282 ENST00000527717(uc021qra.1) ENST00000526014 ENST00000524656
    ENST00000584394 ENST00000529335 ENST00000583233 ENST00000583660 ENST00000524841
    ENST00000527429 ENST00000530956 ENST00000579486 ENST00000584230 ENST00000534125
    ENST00000527053 ENST00000540359(uc001prp.2 uc001prq.2) ENST00000539526(uc021qqy.1 uc021qqz.1 uc001prr.2 uc001pro.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FXYD6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FXYD6 (see all 12):
    hsa-miR-137 hsa-miR-2110 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1253 hsa-miR-4261 hsa-miR-2355-5p hsa-miR-4279
    SwitchGear 3'UTR luciferase reporter plasmidFXYD6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FXYD6
    Predesigned siRNA for gene silencing in human, mouse, rat FXYD6
    Clone
    Products:
         
    OriGene clones in human, mouse for FXYD6 (see all 31)
    OriGene ORF clones in mouse, rat for FXYD6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): FXYD6 (NM_022003)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FXYD6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXYD6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FXYD6
    OriGene qSTAR qPCR primer pairs in human, mouse for FXYD6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FXYD6
      QuantiTect SYBR Green Assays in human, mouse, rat FXYD6
      QuantiFast Probe-based Assays in human, mouse, rat FXYD6

    Selected AceView cDNA sequences (see all 580):

    BG236838 BQ722960 BM914401 CB156271 T08919 BE264820 CR606899 BM695768 
    CR593024 CD105499 BU193397 AL546677 CR608496 BF346097 BM709510 CR623064 
    BE207153 F04885 CR604957 CR618856 BU736395 AK092198 CA449781 CR603146 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FXYD6 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
    SP1:                                                                                -                     
    SP2:                                                                                -                     
    SP3:                          -           -                                                               
    SP4:        -     -           -           -                                                               
    SP5:                                                                                -                     


    ECgene alternative splicing isoforms for FXYD6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FXYD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTCTGGGA
    FXYD6 Expression
    About this image


    FXYD6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 19) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Adult Dopaminergic Neurons Ventral Tegmental Area
             Thalamus
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Zeugopod Epiphyseal End
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Cartilage (Muscoskeletal System)    fully expand to see all 4 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Epithelial Cells
             Outer Root Sheath Cells Outer Root Sheath
    FXYD6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FXYD6 Protein Expression
        Custom PCR Arrays for FXYD6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FXYD6
    OriGene qSTAR qPCR primer pairs in human, mouse for FXYD6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FXYD6
    QuantiTect SYBR Green Assays in human, mouse, rat FXYD6
    QuantiFast Probe-based Assays in human, mouse, rat FXYD6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FXYD6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fxyd61 , 5 FXYD domain-containing ion transport regulator 61, 5 87.23(n)1
    93.62(a)1
      9 (24.84 cM)5
    590951  NM_022004.61  NP_071287.11 
     453701855 
    chicken
    (Gallus gallus)
    Aves FXYD61 FXYD domain containing ion transport regulator 6 75.44(n)
    76.84(a)
      770406  NM_001080879.1  NP_001074348.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fxyd61 FXYD domain containing ion transport regulator 6 67.03(n)
    69.89(a)
      100125148  NM_001103045.1  NP_001096515.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi25c122 wufi25c12 76.04(n)   333987  BC054135.1 


    ENSEMBL Gene Tree for FXYD6 (if available)
    TreeFam Gene Tree for FXYD6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FXYD6 gene
    FXYD12  FXYD6-FXYD22  
    6 SIMAP similar genes for FXYD6 using alignment to 4 protein entries:     FXYD6_HUMAN (see all proteins):
    FXYD6P3    FXYD2    FXYD7    FXYD3    FXYD5    FXYD1

    Find genes that share paralogs with FXYD6           About GenesLikeMe


    3 Pseudogenes.org Pseudogenes for FXYD6
    PGOHUM00000238415 PGOHUM00000238750 PGOHUM00000258438


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FXYD6 (see all 894)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1407743091,2
    Cuntested1119727452(+) CTTCTC/G/TCTTTT 10 K E mis11EU 1319
    rs107902141,2
    C,F,A,H--113641026(+) TGCTTC/TAGGCT 5 -- ds500111Minor allele frequency- T:0.37NA WA CSA EA 373
    rs1925375381,2
    --113641052(+) TTACAC/GGTATG 5 -- ds50010--------
    rs108921841,2
    C,F,A,H--113641064(+) GTCACC/TACCCC 5 -- ds500118Minor allele frequency- T:0.22NS EA NA WA 1936
    rs1158113611,2
    F--113641190(+) GCTCCA/CAGACA 5 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1460720051,2
    --113641284(+) AATGGA/CGGGAA 5 -- ds50010--------
    rs1843947281,2
    --113641295(+) GGTGCA/GGGACG 5 -- ds50010--------
    rs2011974321,2
    --113641309(+) GGCTG-/AGCAGGAG 5 -- ds50010--------
    rs2004342661,2
    --113641313(+) CAGGA-/GGAGAG 5 -- ds50010--------
    rs1429910351,2
    C--113641387(+) CTGAC-/GGGGCT 5 -- ds50010--------

    HapMap Linkage Disequilibrium report for FXYD6 (117707691 - 117748201 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FXYD6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526267CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FXYD6
    DNA2.0 Custom Variant and Variant Library Synthesis for FXYD6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606683    OMIM disorders: --

    UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3
  • Schizophrenia 2 (SCZD2) [MIM:603342]: A complex, multifactorial psychotic disorder or group of disorders
    characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g.
    inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries,
    withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it
    is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild
    impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive
    function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are
    often given the diagnosis of schizoaffective disorder. Note=Disease susceptibility is associated with variations
    affecting the gene represented in this entry

  • 1 disease from the University of Copenhagen DISEASES database for FXYD6:
    Schizophrenia

    Find genes that share disorders with FXYD6           About GenesLikeMe

    Genetic Association Database (GAD): FXYD6
    Human Genome Epidemiology (HuGE) Navigator: FXYD6 (5 documents)

    Export disorders for FXYD6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FXYD6 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with FXYD6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia. (PubMed id 17357072)1, 2, 4, 9 Choudhury K....Gurling H.M.D. (Am. J. Hum. Genet. 2007)
    2. A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population. (PubMed id 18455306)1, 4, 9 Ito Y....Ozaki N. (Neurosci. Lett. 2008)
    3. A novel replicated association between FXYD6 gene and schizophrenia. (PubMed id 21216238)1, 4 Zhong N....Ma J. (Biochem. Biophys. Res. Commun. 2011)
    4. No association between the FXYD6 gene and schizophrenia in the Chinese Han population. (PubMed id 20149392)1, 4 Zhang J....He G. (J Psychiatr Res 2010)
    5. Failure to confirm genetic association of the FXYD6 gene with schizophrenia: the Japanese population and meta-analysis. (PubMed id 20468077)1, 4 Iwata Y....Yoshikawa T. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    9. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    10. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PubMed id 10950925)1, 3 Sweadner K.J. and Rael E. (Genomics 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 53826 HGNC: 4030 AceView: FXYD6 Ensembl:ENSG00000137726 euGenes: HUgn53826
    ECgene: FXYD6 H-InvDB: FXYD6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FXYD6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FXYD6 gene:
    Search GeneIP for patents involving FXYD6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for FXYD6  
     OriGene qPCR primer pairs and template standards for FXYD6   OriGene Protein Over-expression Lysate for FXYD6  
     OriGene MassSpec something-or-other for FXYD6   OriGene clones in human, mouse for FXYD6  
     OriGene qSTAR qPCR primer pairs in human, mouse for FXYD6   OriGene Purified Protein for FXYD6  
     OriGene ORF clones in mouse, rat for FXYD6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FXYD6   OriGene Custom Protein Services for FXYD6  

     
     
     Block miRNA regulation of human, mouse, rat FXYD6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FXYD6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FXYD6 Predesigned siRNA for gene silencing in human, mouse, rat FXYD6
     QuantiFast Probe-based Assays in human, mouse, rat FXYD6 QuantiTect SYBR Green Assays in human, mouse, rat FXYD6
     Custom PCR Arrays for FXYD6 Search Chromatin IP Primers for FXYD6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FXYD6  Search GeneGlobe Interaction Network for FXYD6
     Regulatory tfbs in FXYD6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FXYD6 GenScript cDNA clones with any tag delivered in your preferred vector for FXYD6
     GenScript Custom Assay Services for FXYD6 GenScript Custom overexpressing Cell Line Services for FXYD6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FXYD6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FXYD6
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FXYD6 antibodies
     FXYD6 proteins
     FXYD6 lysates
     Antibodies for FXYD6
     See all of Abcam's Antibodies, Kits and Proteins for FXYD6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for FXYD6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD6
     SwitchGear 3'UTR luciferase reporter plasmids for FXYD6
     SwitchGear Promoter luciferase reporter plasmids for FXYD6
     Search ThermoFisher Antibodies for FXYD6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXYD6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FXYD6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FXYD6
     Search LSBio for Antibodies for FXYD6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for FXYD6
      Search eBioscience for proteins for FXYD6
      Search eBioscience for elisas for FXYD6
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FXYD6 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4