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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FXYD6 Gene

protein-coding   GIFtS: 53
GCID: GC11M117741

FXYD domain containing ion transport regulator 6

(Previous name: FXYD domain-containing ion transport regulator 6 )
 Explore 5 diseases affiliated with
FXYD6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FXYD6    

Aliases
for FXYD6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
FXYD Domain Containing Ion Transport Regulator 61 2
FXYD Domain-Containing Ion Transport Regulator 61 2
Phosphohippolin3
Phosphohippolin3

External Ids:    HGNC: 40301   Entrez Gene: 538262   Ensembl: ENSG000001377267   OMIM: 6066835   UniProtKB: Q9H0Q33   

Export aliases for FXYD6 gene to outside databases

Previous GC identifers: GC11M120064 GC11M119219 GC11M117245 GC11M117212 GC11M113641


Summaries
for FXYD6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FXYD6:
This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes
phosphohippolin, which likely affects the activity of Na,K-ATPase. Multiple alternatively spliced transcript variants
encoding the same protein have been described. Related pseudogenes have been identified on chromosomes 10 and X.
Read-through transcripts have been observed between this locus and the downstream sodium/potassium-transporting ATPase
subunit gamma (FXYD2, GeneID 486) locus.(provided by RefSeq, Feb 2011)




Genomic Views
for FXYD6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_033899.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FXYD6 gene promoter:
         MAZR   Pax-5   SREBP-1c   FOXD3   MyoD   CUTL1   SREBP-1b   HEN1   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FXYD6 promoter sequence
   Search SABiosciences Chromatin IP Primers for FXYD6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXYD6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23.3   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23.3

FXYD6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M117741:  view genomic region     (about GC identifiers)

Start:
 117,707,693 bp from pter      End:
 117,748,201 bp from pter
Size:
 40,509 bases      Orientation:
 minus strand

Proteins
for FXYD6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3 (See protein sequence)
Recommended Name: FXYD domain-containing ion transport regulator 6 precursor  
Size: 95 amino acids; 10542 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAQ89335.1; Type=Frameshift; Positions=93;
Secondary accessions: A8K0R4 J3QLD2 Q6FIG9 Q6UW52
Alternative splicing: 2 isoforms:  Q9H0Q3-1   Q9H0Q3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FXYD6: NX_Q9H0Q3

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9H0Q3

    • FXYD6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001158303.1  NP_001158304.1  NP_001158308.1  NP_001158309.1  NP_071286.1  

    ENSEMBL proteins: 
     ENSP00000260282   ENSP00000431446   ENSP00000433312   ENSP00000431427   ENSP00000463160  
     ENSP00000436629   ENSP00000431913   ENSP00000464057   ENSP00000463158   ENSP00000464144  
     ENSP00000444243   ENSP00000442756  
    Reactome Protein details: Q9H0Q3
    Human Recombinant Protein Products: 
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    Novus Biologicals FXYD6 Protein
    Novus Biologicals FXYD6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FXYD6

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--


    FXYD6 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FXYD6

    Protein Domains /
    Families
    for FXYD6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FXYD6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000272 Ion-transport_regulator_FXYD

    Graphical View of Domain Structure for InterPro Entry Q9H0Q3

    ProtoNet protein and cluster: Q9H0Q3

    1 Blocks protein family: IPB000272 FXYD protein

    UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3
    Similarity: Belongs to the FXYD family


    Function
    for FXYD6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FXYD6
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    hsa-miR-137 hsa-miR-2110 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1253 hsa-miR-4261 hsa-miR-2355-5p hsa-miR-4279
    SwitchGear 3'UTR luciferase reporter plasmid: FXYD6 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: FXYD6
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005216ion channel activity IEA--


    FXYD6 for ontologies           About GeneDecksing


    Animal Models:
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Fxyd6):
     behavior/neurological 

    FXYD6 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FXYD6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Ion transport by P-type ATPases0.32
    2SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for FXYD6
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases



    FXYD6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FXYD6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/26 Interacting proteins for FXYD6 (Q9H0Q32, 3 ENSP000002602824) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCDC90BQ9GZT62, 3MINT-65445 I2D: score=5 
    GDF9O603832, 3MINT-65438 I2D: score=5 
    HAUS2Q9NVX02, 3MINT-65446 I2D: score=5 
    TP53P046372, 3MINT-65439 I2D: score=5 
    UNC119Q134322, 3MINT-65442 I2D: score=5 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--


    FXYD6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FXYD6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FXYD6
    Search CenterWatch for drugs/clinical trials and news about FXYD6 

    Transcripts
    for FXYD6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FXYD6 gene (5 alternative transcripts): 
    NM_001164831.2  NM_001164832.2  NM_001164836.2  NM_001164837.2  NM_022003.3  

    Unigene Cluster for FXYD6:

    FXYD domain containing ion transport regulator 6
    Hs.413137  [show with all ESTs]
    Unigene Representative Sequence: AK092198
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000260282 ENST00000527717(uc021qra.1) ENST00000526014 ENST00000524656
    ENST00000584394 ENST00000529335 ENST00000583233 ENST00000583660 ENST00000524841
    ENST00000527429 ENST00000530956 ENST00000579486 ENST00000584230 ENST00000534125
    ENST00000527053 ENST00000540359(uc001prp.2 uc001prq.2) ENST00000539526(uc021qqy.1 uc021qqz.1 uc001prr.2 uc001pro.2)


    miRNA
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    8/12 QIAGEN miScript miRNA Assays for microRNAs that regulate FXYD6 (see all 12):
    hsa-miR-137 hsa-miR-2110 hsa-miR-3616-5p hsa-miR-3647-5p hsa-miR-1253 hsa-miR-4261 hsa-miR-2355-5p hsa-miR-4279
    SwitchGear 3'UTR luciferase reporter plasmid: FXYD6 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: FXYD6
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXYD6
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    Additional cDNA sequence: 

    AK055389.1 AK092198.1 AK289629.1 AK290757.1 AK311736.1 AL136699.1 AL832811.1 AY358976.1 
    BC018652.2 BC093040.1 BT006717.1 CR533457.1 

    24/32 DOTS entries (see all 32):

    DT.100885501  DT.95178358  DT.91696981  DT.100885500  DT.100885491  DT.40106468  DT.91769919  DT.100885497 
    DT.100885494  DT.100739618  DT.120713689  DT.95178359  DT.120713848  DT.95198622  DT.100805742  DT.102834806 
    DT.120713751  DT.91769909  DT.95178380  DT.100030974  DT.100732894  DT.100770886  DT.120713856  DT.120713884 

    24/580 AceView cDNA sequences (see all 580):

    BM672897 BQ722960 BQ897630 BP372334 AL539233 BG820880 AI220325 BX441172 
    BQ182158 AW090426 BF529171 BM914601 W94427 CR600841 BQ882521 H19602 
    AW161130 BG057893 CR604290 BX360494 CR611517 BE382713 AI686295 BG055921 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FXYD6 (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c
    SP1:                                                                                -                     
    SP2:                                                                                -                     
    SP3:                          -           -                                                               
    SP4:        -     -           -           -                                                               
    SP5:                                                                                -                     


    ECgene alternative splicing isoforms for FXYD6

    Expression
    for FXYD6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FXYD6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GGCTCTGGGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FXYD6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    OvaryPrimordial FolliclePre-Granulosa CellsOvary
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11) 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)Cartilage, Neural Crest
    PureStem™ progenitor EN7 (Embryonic Progenitor Cell)
    PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor SM22 (Embryonic Progenitor Cell)
    Sox17-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    HyStem+TGF?3+GDF5-induced SK11 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage
    HyStem+TGF?3+GDF5-induced SM30 cells (HyStem+TGF?3+GDF5 in...)Bone, Cartilage

    See FXYD6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FXYD6

    SOURCE GeneReport for Unigene cluster: Hs.413137
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    In Situ
    Assay Products:     
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    Orthologs
    for FXYD6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FXYD6 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FXYD61 FXYD domain containing ion transport regulator 6 75.44(n)
    76.84(a)    		   770406  NM_001080879.1  NP_001074348.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufi25c122 wufi25c12 76.04(n)   333987  BC054135.1 


    ENSEMBL Gene Tree for FXYD6 (if available)
    TreeFam Gene Tree for FXYD6 (if available) 

    Paralogs
    for FXYD6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FXYD6 gene
    FXYD12  FXYD6-FXYD22  
    6 SIMAP similar genes for FXYD6 using alignment to 4 protein entries:     FXYD6_HUMAN (see all proteins):
    FXYD6P3    FXYD2    FXYD7    FXYD5    FXYD1    FXYD3

    FXYD6 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for FXYD6
    PGOHUM00000238415 PGOHUM00000238750 PGOHUM00000258438


    Genomic Variants
    for FXYD6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/778 NCBI SNPs in FXYD6 are shown (see all 778)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1407743091,2
    		Cother119727452(+) CTTCTC/G/TCTTTT 15 K Q E mis11EU 1319
    rs760823621,2
    		F,--113642635(+) AGGACC/TGCAGG 5 -- ut311Minor allele frequency- T:0.04NA 120
    rs764251891,2
    		C,--113643175(+) CTTCCC/GAGATT 5 -- int12Minor allele frequency- G:0.08NA 122
    rs750665291,2
    		--113643426(+) TGCATC/TGGGCA 5 -- int11Minor allele frequency- T:0.01WA 118
    rs31682381,2
    		C,F,O,H,--113643477(+) TAAACT/GTATAT 5 -- int19Minor allele frequency- G:0.02MN NA NS EA 864
    rs112165771,2
    		C,F,H,--113643982(+) CACCAC/TGGAAA 5 -- int128Minor allele frequency- T:0.09NA NS EA WA CSA 3050
    rs1131363821,2
    		--113644078(+) ACTCGG/ACCAGT 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs1119611501,2
    		--113644140(+) ACTTCG/AGGTGT 5 -- int12Minor allele frequency- A:0.02CSA NA 122
    rs1130678501,2
    		--113644295(+) ATGGCG/AACAGG 5 -- int11Minor allele frequency- A:0.50CSA 2
    rs1134005491,2
    		--113644446(+) CAGCAG/ACCGTG 5 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for FXYD6 (117707693 - 117748201 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FXYD6: --

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    Disorders / Diseases
    for FXYD6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FXYD6 for disorders           About GeneDecksing

    OMIM gene information: 606683    OMIM disorders: --

    UniProtKB/Swiss-Prot: FXYD6_HUMAN, Q9H0Q3
  • Genetic variations in FXYD6 are associated with susceptibility to schizophrenia type 2 (SCZD2) [MIM:603342]. A
    • complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content
    of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to
    the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless
    behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are
    primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in
    which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar
    disorder symptoms and are often given the diagnosis of schizoaffective disorder

    5 diseases for FXYD6:    About MalaCards
    psychotic disorder    schizoaffective disorder    dementia    schizophrenia
    neuronitis

    1 disease from the University of Copenhagen DISEASES database for FXYD6:
    Schizophrenia
    Human Genome Epidemiology (HuGE) Navigator: FXYD6 (5 documents)

    Export disorders for FXYD6 gene to outside databases

    Publications
    for FXYD6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FXYD6 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with FXYD6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. A genetic association study of chromosome 11q22-24 in two different samples implicates the FXYD6 gene, encoding phosphohippolin, in susceptibility to schizophrenia. (PubMed id 17357072)1, 2, 9 Choudhury K....Gurling H.M.D. (2007)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    6. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PubMed id 10950925)1, 3 Sweadner K.J. and Rael E. (2000)
    7. A genetic association study of the FXYD domain containing ion transport regulator 6 (FXYD6) gene, encoding phosphohippolin, in susceptibility to schizophrenia in a Japanese population. (PubMed id 18455306)1, 9 Ito Y....Ozaki N. (2008)
    8. A novel replicated association between FXYD6 gene and schizophrenia. (PubMed id 21216238)1 Zhong N....Ma J. (2011)
    9. [A family-based association study of FXYD6 gene polym orphisms and schizophrenia]. (PubMed id 21983730)1 Jiao L.Z....Ma J. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    External Searches for FXYD6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing FXYD6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 53826 HGNC: 4030 AceView: FXYD6 Ensembl:ENSG00000137726 euGenes: HUgn53826
    ECgene: FXYD6 H-InvDB: FXYD6

    Other Databases showing FXYD6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FXYD6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FXYD6 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FXYD6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FXYD6 gene:
    Search GeneIP for patents involving FXYD6

    GeneCards and IP:
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