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Aliases for FXYD5 Gene

Aliases for FXYD5 Gene

  • FXYD Domain Containing Ion Transport Regulator 5 2 3 5
  • Dysadherin 2 3 4
  • FXYD Domain-Containing Ion Transport Regulator 5 2 3
  • DYSAD 3 4
  • IWU1 3 4
  • Keratinocytes Associated Transmembrane Protein 1 3
  • HSPC113 3
  • PRO6241 3
  • KCT1 3
  • OIT2 3
  • RIC 3

External Ids for FXYD5 Gene

Previous GeneCards Identifiers for FXYD5 Gene

  • GC19P036263
  • GC19P036094
  • GC19P040321
  • GC19P040337
  • GC19P035645
  • GC19P032154

Summaries for FXYD5 Gene

Entrez Gene Summary for FXYD5 Gene

  • This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D.,, Sep 2009]

GeneCards Summary for FXYD5 Gene

FXYD5 (FXYD Domain Containing Ion Transport Regulator 5) is a Protein Coding gene. GO annotations related to this gene include actin binding and sodium channel regulator activity.

UniProtKB/Swiss-Prot for FXYD5 Gene

  • Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.

Gene Wiki entry for FXYD5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD5 Gene

Genomics for FXYD5 Gene

Regulatory Elements for FXYD5 Gene

Enhancers for FXYD5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F035161 1.3 Ensembl ENCODE 25.6 +10.9 10948 8.1 HDGF ATF1 PKNOX1 ZNF121 ELK1 GATA2 FOS KLF13 ZNF263 NFYC FXYD5 SDHAF1 TMEM147-AS1 FAM187B FXYD3 MIR6887 ENSG00000179066 HPN-AS1 HAUS5 LIN37
GH19F035175 0.6 Ensembl ENCODE 21.8 +21.3 21312 1.1 PKNOX1 KLF1 NRF1 BHLHE40 ZNF175 ZMYM3 KLF17 CEBPB RAD51 GLIS2 FXYD5 FAM187B FXYD3 MIR6887 HPN-AS1 ENSG00000179066 HAMP LRFN3 DMKN RBM42
GH19F035196 0.7 ENCODE 21.4 +42.1 42065 1.3 BCOR ZNF362 ZNF266 KLF17 RAD21 YY1 ZNF121 ATF3 ZNF747 ZBTB33 FXYD5 FAM187B LSR USF2 FXYD3 MIR6887 ENSG00000179066 HPN-AS1 LRFN3 RBM42
GH19F035171 0.6 ENCODE 21.2 +17.9 17924 2.5 CBX3 FOXA1 OSR2 ARID1B IKZF1 ZBTB33 SETDB1 TRIM28 MGA FXYD5 FAM187B MIR6887 FXYD3 ENSG00000179066 HPN-AS1 HAMP DMKN USF2 ENSG00000271049
GH19F035202 1.3 FANTOM5 Ensembl ENCODE 15.6 +50.8 50826 6.1 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 ZNF302 TMEM147-AS1 RBM42 ZNF792 KIAA0355 HAUS5 KMT2B ENSG00000267049 SDHAF1 LRFN3 LOC101927572
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FXYD5 on UCSC Golden Path with GeneCards custom track

Promoters for FXYD5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001418934 184 2201 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF416 KLF13

Transcription factor binding sites by QIAGEN in the FXYD5 gene promoter:

Genomic Location for FXYD5 Gene

35,154,716 bp from pter
35,169,885 bp from pter
15,170 bases
Plus strand

Genomic View for FXYD5 Gene

Genes around FXYD5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD5 Gene

Proteins for FXYD5 Gene

  • Protein details for FXYD5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 5
    Protein Accession:
    Secondary Accessions:
    • B7WNZ8
    • Q6UW44
    • Q9HC34
    • Q9P039

    Protein attributes for FXYD5 Gene

    178 amino acids
    Molecular mass:
    19472 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FXYD5 Gene


neXtProt entry for FXYD5 Gene

Post-translational modifications for FXYD5 Gene

No data available for DME Specific Peptides for FXYD5 Gene

Domains & Families for FXYD5 Gene

Protein Domains for FXYD5 Gene

Suggested Antigen Peptide Sequences for FXYD5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FXYD family.
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD5: view

No data available for Gene Families for FXYD5 Gene

Function for FXYD5 Gene

Molecular function for FXYD5 Gene

UniProtKB/Swiss-Prot Function:
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis.

Gene Ontology (GO) - Molecular Function for FXYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IDA 11756660
GO:0005216 ion channel activity IEA --
GO:0017080 sodium channel regulator activity IBA --
GO:0045296 cadherin binding IDA 11756660
genes like me logo Genes that share ontologies with FXYD5: view
genes like me logo Genes that share phenotypes with FXYD5: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FXYD5

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FXYD5 Gene

Localization for FXYD5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD5 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FXYD5 Gene COMPARTMENTS Subcellular localization image for FXYD5 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 3
extracellular 2
cytoskeleton 1
lysosome 1
mitochondrion 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FXYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IDA 11756660
genes like me logo Genes that share ontologies with FXYD5: view

Pathways & Interactions for FXYD5 Gene

SuperPathways for FXYD5 Gene

No Data Available

Interacting Proteins for FXYD5 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q96DB9-FXYD5_HUMAN ENSP00000344254 for FXYD5 Gene via IID STRING

Gene Ontology (GO) - Biological Process for FXYD5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0030033 microvillus assembly NAS 11756660
GO:0034220 ion transmembrane transport IEA --
GO:0046588 negative regulation of calcium-dependent cell-cell adhesion NAS 11756660
genes like me logo Genes that share ontologies with FXYD5: view

No data available for Pathways by source and SIGNOR curated interactions for FXYD5 Gene

Transcripts for FXYD5 Gene

Unigene Clusters for FXYD5 Gene

FXYD domain containing ion transport regulator 5:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD5 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - - - - -
SP10: -
SP11: - - - - - -
SP12: - -

Relevant External Links for FXYD5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD5 Gene

mRNA expression in normal human tissues for FXYD5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD5 Gene

This gene is overexpressed in Whole Blood (x10.8).

NURSA nuclear receptor signaling pathways regulating expression of FXYD5 Gene:


SOURCE GeneReport for Unigene cluster for FXYD5 Gene:

genes like me logo Genes that share expression patterns with FXYD5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FXYD5 Gene

Orthologs for FXYD5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FXYD5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FXYD5 34 35
  • 98.88 (n)
(Canis familiaris)
Mammalia LOC102156583 34
  • 68.89 (n)
FXYD5 35
  • 51 (a)
(Bos Taurus)
Mammalia FXYD5 34 35
  • 67.26 (n)
(Rattus norvegicus)
Mammalia Fxyd5 34
  • 61.46 (n)
(Mus musculus)
Mammalia Fxyd5 34 16 35
  • 60.34 (n)
Species where no ortholog for FXYD5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD5 Gene

Gene Tree for FXYD5 (if available)
Gene Tree for FXYD5 (if available)

Paralogs for FXYD5 Gene

(3) SIMAP similar genes for FXYD5 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FXYD5: view

No data available for Paralogs for FXYD5 Gene

Variants for FXYD5 Gene

Sequence variations from dbSNP and Humsavar for FXYD5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs386352302 Uncertain significance 35,160,789(+) ACAAG(A/G)GCACC intron-variant, nc-transcript-variant, reference, missense
rs10406424 -- 35,168,027(+) cagca(A/T)gggca intron-variant
rs10410144 -- 35,162,592(+) TTCTT(A/G)TAAGG intron-variant
rs10419853 -- 35,167,501(+) gggcc(C/G)agggc intron-variant
rs10425979 -- 35,161,452(+) ctaga(A/G)aacaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FXYD5 Gene

Variant ID Type Subtype PubMed ID
dgv1774n106 CNV deletion 24896259
dgv636e199 CNV deletion 23128226
dgv6410n54 CNV loss 21841781
esv2758757 CNV loss 17122850
esv3556326 CNV deletion 23714750
nsv2470 CNV deletion 18451855
nsv516540 CNV loss 19592680
nsv579358 CNV loss 21841781
nsv9709 CNV loss 18304495

Variation tolerance for FXYD5 Gene

Residual Variation Intolerance Score: 69.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FXYD5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD5 Gene

Disorders for FXYD5 Gene

Relevant External Links for FXYD5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FXYD5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FXYD5 Gene

Publications for FXYD5 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  2. Dysadherin expression in gastrointestinal stromal tumors (GISTs). (PMID: 19217217) Liang J.F. … Wang H.K. (Pathol. Res. Pract. 2009) 3 22 64
  3. Differential expression of dysadherin in papillary thyroid carcinoma and microcarcinoma: correlation with E-cadherin. (PMID: 18677652) Batistatou A. … Scopa C.D. (Endocr. Pathol. 2008) 3 22 64
  4. FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia. (PMID: 18263667) Miller T.J. … Davis P.B. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008) 3 22 64
  5. In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin. (PMID: 17437014) Batistatou A. … Charalabopoulos K. (Br. J. Cancer 2007) 3 22 64

Products for FXYD5 Gene

Sources for FXYD5 Gene

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