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FXYD5 Gene

protein-coding   GIFtS: 58
GCID: GC19P035645

FXYD Domain Containing Ion Transport Regulator 5

(Previous name: FXYD domain-containing ion transport regulator 5)
  See FXYD5-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
FXYD Domain Containing Ion Transport Regulator 51 2     OIT22
FXYD Domain-Containing Ion Transport Regulator 51 2     PRO62412
dysadherin1 2     RIC2
DYSAD2 3     Keratinocytes Associated Transmembrane Protein 12
IWU12 3     Dysadherin3
KCT12     

External Ids:    HGNC: 40291   Entrez Gene: 538272   Ensembl: ENSG000000893277   OMIM: 6066695   UniProtKB: Q96DB93   
ORGUL members:         

Export aliases for FXYD5 gene to outside databases

Previous GC identifers: GC19P036263 GC19P036094 GC19P040321 GC19P040337 GC19P032154


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FXYD5 Gene:
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence
domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The
approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5
has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase,
regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and
FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology
has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the
C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in
the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability
to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers.
Alternative splicing results in multiple transcript variants. (RefSeq curation by Kathleen J. Sweadner, Ph.D.,
sweadner@helix.mgh.harvard.edu., Sep 2009)

GeneCards Summary for FXYD5 Gene:
FXYD5 (FXYD domain containing ion transport regulator 5) is a protein-coding gene. Diseases associated with FXYD5 include intracranial hypotension. GO annotations related to this gene include ion channel activity and actin binding.

UniProtKB/Swiss-Prot: FXYD5_HUMAN, Q96DB9
Function: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis

Gene Wiki entry for FXYD5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FXYD5 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFXYD5 promoter sequence
   Search Chromatin IP Primers for FXYD5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FXYD5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

FXYD5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035645:  view genomic region     (about GC identifiers)

Start:
35,645,625 bp from pter      End:
35,660,788 bp from pter
Size:
15,164 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FXYD5_HUMAN, Q96DB9 (See protein sequence)
Recommended Name: FXYD domain-containing ion transport regulator 5 precursor  
Size: 178 amino acids; 19472 Da
Secondary accessions: B7WNZ8 Q6UW44 Q9HC34 Q9P039
Alternative splicing: 2 isoforms:  Q96DB9-1   Q96DB9-2   

Explore the universe of human proteins at neXtProt for FXYD5: NX_Q96DB9

Explore proteomics data for FXYD5 at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Ser127
  • Modification sites at PhosphoSitePlus

  • See FXYD5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001158077.1  NP_054883.3  NP_659003.1  

    ENSEMBL proteins: 
     ENSP00000376052   ENSP00000444839   ENSP00000376053   ENSP00000465174   ENSP00000443390  
     ENSP00000465667   ENSP00000468168   ENSP00000344254   ENSP00000467053   ENSP00000393848  
     ENSP00000376051  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000272 Ion-transport_regulator_FXYD

    Graphical View of Domain Structure for InterPro Entry Q96DB9

    ProtoNet protein and cluster: Q96DB9

    1 Blocks protein domain: IPB000272 FXYD protein

    UniProtKB/Swiss-Prot: FXYD5_HUMAN, Q96DB9
    Similarity: Belongs to the FXYD family


    Find genes that share domains with FXYD5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FXYD5_HUMAN, Q96DB9
    Function: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IDA11756660
    GO:0005216ion channel activity IEA--
    GO:0045296cadherin binding IDA11756660
         
    Find genes that share ontologies with FXYD5           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FXYD5
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    Predesigned siRNA for gene silencing in human, mouse, rat FXYD5

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FXYD5_HUMAN, Q96DB9: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane ----
    GO:0016021integral component of membrane IDA11756660

    Find genes that share ontologies with FXYD5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FXYD5: 
              Tumor Metastasis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FXYD5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for FXYD5 (ENSP000003442544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0030033microvillus assembly NAS11756660
    GO:0046588negative regulation of calcium-dependent cell-cell adhesion NAS11756660

    Find genes that share ontologies with FXYD5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FXYD5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FXYD5 gene (3 alternative transcripts): 
    NM_001164605.1  NM_014164.5  NM_144779.2  

    Unigene Cluster for FXYD5:

    FXYD domain containing ion transport regulator 5
    Hs.333418  [show with all ESTs]
    Unigene Representative Sequence: BX648809
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000392218 ENST00000543307(uc010xsq.2) ENST00000392219(uc002nyg.2)
    ENST00000592290 ENST00000541435(uc021usk.1) ENST00000590686 ENST00000496493
    ENST00000342879(uc002nyh.2) ENST00000588699 ENST00000423817(uc021usl.1)
    ENST00000591716 ENST00000586925 ENST00000392217(uc002nyi.2)
    miRNA
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    Block miRNA regulation of human, mouse, rat FXYD5 using miScript Target Protectors
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    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FXYD5
      QuantiFast Probe-based Assays in human, mouse, rat FXYD5

    Additional mRNA sequence: 

    AB072911.1 AF161462.1 AK304012.1 AY157582.1 AY358991.1 BC009642.2 BC013834.1 BC018798.1 
    BT007343.1 BX648809.1 NR_028406.1 

    13 DOTS entries:

    DT.447051  DT.95226378  DT.95378318  DT.91903060  DT.100794284  DT.95378213  DT.97860203  DT.121497607 
    DT.121497616  DT.95333277  DT.100794285  DT.91725463  DT.92438425 

    Selected AceView cDNA sequences (see all 310):

    BQ941279 NM_014164 BI792844 BI908365 BM912507 BU164524 BM916150 BQ181537 
    CB124603 AI651952 NM_144779 AA485829 AA643965 BM824486 AA297863 BM915371 
    BG574566 BM826407 BE552409 BU178888 AJ713839 W95348 BM550889 BM703034 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FXYD5 (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
    SP1:                    -     -     -     -     -           -           -     -           -                                       
    SP2:                    -     -     -     -     -                       -     -           -                                       
    SP3:                                                        -           -     -           -                                       
    SP4:                    -     -     -     -     -           -                 -           -                                       
    SP5:                    -     -     -     -                 -           -     -           -                                       


    ECgene alternative splicing isoforms for FXYD5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FXYD5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGATGACCC
    FXYD5 Expression
    About this image


    FXYD5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Lung (Respiratory System)
     
     Gall Bladder (Hepatobiliary System)
     
     Placenta (Extraembryonic Tissues)
    FXYD5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FXYD5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.333418
        Pathway & Disease-focused RT2 Profiler PCR Array including FXYD5: 
              Tumor Metastasis in human mouse rat

    Primer
    Products:
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    QuantiTect SYBR Green Assays in human, mouse, rat FXYD5
    QuantiFast Probe-based Assays in human, mouse, rat FXYD5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FXYD5 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fxyd51 , 5 FXYD domain-containing ion transport regulator 51, 5 60.34(n)1
    48.85(a)1
      7 (19.29 cM)5
    183011  NM_001287217.11  NP_001274146.11 
     310327225 


    ENSEMBL Gene Tree for FXYD5 (if available)
    TreeFam Gene Tree for FXYD5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FXYD5 gene
    3 SIMAP similar genes for FXYD5 using alignment to 5 protein entries:     FXYD5_HUMAN (see all proteins):
    KCT1    FXYD6    FXYD7

    Find genes that share paralogs with FXYD5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FXYD5 (see all 353)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs24519921,2
    C,H--35645727(+) TCTCGC/TGCGCC 4 -- ut51 int1 us2k1 nc-transcript-variantese314Minor allele frequency- T:0.00NS EA NA CSA WA 789
    rs730419991,2
    --35645813(+) CCCCCC/TATCCA 4 -- int1 us2k1 nc-transcript-variant0--------
    rs621113711,2
    C,F--35645877(+) CTCCCG/TCCCGC 4 -- int1 ut51 nc-transcript-variant4Minor allele frequency- T:0.11NA EA 244
    rs16339251,2
    C--35645915(+) ACCCCC/TCTCGG 4 -- int1 ut51 nc-transcript-variantese36Minor allele frequency- T:0.30MN NA CSA WA EA 545
    rs1847503141,2
    --35645998(+) CTGAGC/TGCGGG 4 -- int1 nc-transcript-variant0--------
    rs1479433421,2
    C--35646262(+) GAAGCA/TGGGTG 4 -- int1 nc-transcript-variant0--------
    rs1380090171,2
    C--35646311(+) TGAGG-/CCCAGC 4 -- int1 nc-transcript-variant0--------
    rs1121241041,2
    C,F--35646317(+) CCAGCC/AGTCAG 4 -- int1 nc-transcript-variant2Minor allele frequency- A:0.50CSA 4
    rs1490052291,2
    --35646399(+) GCTGCC/TGGAGG 4 -- int1 nc-transcript-variant0--------
    rs1128805481,2
    C--35646453(+) CCACAC/GATGTC 4 -- spa1 nc-transcript-variant1Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for FXYD5 (35645625 - 35660788 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FXYD5:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv636e199CNV Deletion23128226
    nsv516540CNV Loss19592680
    nsv9709CNV Loss18304495
    nsv2470CNV Loss18451855
    dgv3849n71CNV Loss21882294
    essv510CNV CNV17122850
    esv1374CNV CNV17122850
    dgv1075e1CNV Complex17122850
    dgv1076e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606669    OMIM disorders: --

    1 disease for FXYD5:    
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    intracranial hypotension

    1 disease from the University of Copenhagen DISEASES database for FXYD5:
    Intracranial hypotension

    Find genes that share disorders with FXYD5           About GenesLikeMe

    10 Novoseek inferred disease relationships for FXYD5 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metastasis 57 34 15102690 (4), 16570180 (4), 12970317 (2), 15459499 (2) (see all 20)
    primary tumor 33.3 4 16570180 (3), 12970317 (1)
    tumors 33 35 15751018 (3), 12586803 (3), 15536331 (2), 18677652 (2) (see all 15)
    cancer 32.4 17 17442482 (4), 15536331 (2), 15459499 (2), 12618882 (1) (see all 10)
    colorectal carcinoma 25.7 4 12618882 (3), 16570180 (1)
    carcinoma squamous cell 14.6 7 16434892 (2), 15536331 (2), 15459499 (2)
    gastric cancer 11.2 8 15102690 (5)
    carcinoma 0.853 6 12970317 (3), 12672699 (1), 15102690 (1)
    melanoma 0.597 4 15751018 (4)
    breast cancer 0 8 16849564 (5), 17437014 (2)

    Genetic Association Database (GAD): FXYD5
    Human Genome Epidemiology (HuGE) Navigator: FXYD5 (3 documents)

    Export disorders for FXYD5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FXYD5 gene, integrated from 10 sources (see all 59):
    (articles sorted by number of sources associating them with FXYD5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    4. Dysadherin, a cancer-associated cell membrane glycoprotein, down- regulates E-cadherin and promotes metastasis. (PubMed id 11756660)1, 2 Ino Y.... Hirohashi S. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. A cDNA from human bone marrow encoding a protein exhibiting homology to the ATP11/PLM/MAT8 family of transmembrane proteins. (PubMed id 11342114)1, 2 Omasa T.... Wu J.H.D. (Biochim. Biophys. Acta 2001)
    6. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    7. Clinical significance of dysadherin expression in gastric cancer patients. (PubMed id 15102690)1, 9 Shimada Y....Imamura M. (Clin. Cancer Res. 2004)
    8. FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia. (PubMed id 18263667)1, 9 Miller T.J. and Davis P.B. (Am. J. Physiol. Lung Cell Mol. Physiol. 2008)
    9. Prognostic significance of dysadherin expression in esophageal squamous cell carcinoma. (PubMed id 15459499)1, 9 Shimada Y....Imamura M. (Oncology 2004)
    10. Involvement of dysadherin and E-cadherin in the development of testicular tumours. (PubMed id 16333245)1, 9 Batistatou A....Charalabopoulos K.A. (Br. J. Cancer 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 53827 HGNC: 4029 AceView: FXYD5 Ensembl:ENSG00000089327 euGenes: HUgn53827
    ECgene: FXYD5 H-InvDB: FXYD5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FXYD5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FXYD5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FXYD5 gene:
    Search GeneIP for patents involving FXYD5

    Licensable Technologies for FXYD5 gene:
    Weizmann Institute:FXYD5 TARGET TO ANTI CANCER AND ANTI-INFLAMMATORY DRUGS
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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