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Aliases for FXYD4 Gene

Aliases for FXYD4 Gene

  • FXYD Domain Containing Ion Transport Regulator 4 2 3 5
  • FXYD Domain-Containing Ion Transport Regulator 4 2
  • Channel-Inducing Factor 3
  • CHIF 3

External Ids for FXYD4 Gene

Previous GeneCards Identifiers for FXYD4 Gene

  • GC00U990738
  • GC10M043337
  • GC10P043642
  • GC10P043151
  • GC10P043187
  • GC10P043867
  • GC10P040393

Summaries for FXYD4 Gene

Entrez Gene Summary for FXYD4 Gene

  • This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]

GeneCards Summary for FXYD4 Gene

FXYD4 (FXYD Domain Containing Ion Transport Regulator 4) is a Protein Coding gene. Among its related pathways are Ion channel transport and Cardiac conduction. GO annotations related to this gene include ion channel activity and potassium channel activity. An important paralog of this gene is FXYD3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD4 Gene

Genomics for FXYD4 Gene

Regulatory Elements for FXYD4 Gene

Enhancers for FXYD4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FXYD4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FXYD4 Gene

43,371,642 bp from pter
43,376,335 bp from pter
4,694 bases
Plus strand

Genomic View for FXYD4 Gene

Genes around FXYD4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD4 Gene

Proteins for FXYD4 Gene

  • Protein details for FXYD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 4
    Protein Accession:
    Secondary Accessions:
    • Q6UWZ1
    • Q7Z4M5

    Protein attributes for FXYD4 Gene

    89 amino acids
    Molecular mass:
    9373 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FXYD4 Gene

Proteomics data for FXYD4 Gene at MOPED

Post-translational modifications for FXYD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FXYD4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FXYD4 Gene

Domains & Families for FXYD4 Gene

Protein Domains for FXYD4 Gene


Suggested Antigen Peptide Sequences for FXYD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FXYD family.
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD4: view

No data available for Gene Families for FXYD4 Gene

Function for FXYD4 Gene

Gene Ontology (GO) - Molecular Function for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
GO:0017080 sodium channel regulator activity IBA --
genes like me logo Genes that share ontologies with FXYD4: view
genes like me logo Genes that share phenotypes with FXYD4: view

Animal Models for FXYD4 Gene

MGI Knock Outs for FXYD4:

Animal Model Products

  • Taconic Biosciences Mouse Models for FXYD4

miRNA for FXYD4 Gene

miRTarBase miRNAs that target FXYD4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FXYD4 Gene

Localization for FXYD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FXYD4 Gene COMPARTMENTS Subcellular localization image for FXYD4 gene
Compartment Confidence
plasma membrane 5
extracellular 3

Gene Ontology (GO) - Cellular Components for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with FXYD4: view

Pathways & Interactions for FXYD4 Gene

genes like me logo Genes that share pathways with FXYD4: view

Pathways by source for FXYD4 Gene

Interacting Proteins for FXYD4 Gene

Gene Ontology (GO) - Biological Process for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0055085 transmembrane transport TAS --
GO:1903779 regulation of cardiac conduction TAS --
genes like me logo Genes that share ontologies with FXYD4: view

No data available for SIGNOR curated interactions for FXYD4 Gene

Drugs & Compounds for FXYD4 Gene

(1) Drugs for FXYD4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FXYD4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FXYD4: view

Transcripts for FXYD4 Gene

mRNA/cDNA for FXYD4 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FXYD4 Gene

FXYD domain containing ion transport regulator 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP2: -

Relevant External Links for FXYD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD4 Gene

mRNA expression in normal human tissues for FXYD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD4 Gene

This gene is overexpressed in Kidney - Cortex (x42.4).

SOURCE GeneReport for Unigene cluster for FXYD4 Gene Hs.130497

genes like me logo Genes that share expression patterns with FXYD4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FXYD4 Gene

Orthologs for FXYD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FXYD4 35
  • 78.1 (n)
  • 67.14 (a)
(Canis familiaris)
Mammalia FXYD4 35
  • 82.38 (n)
  • 73.56 (a)
FXYD4 36
  • 72 (a)
(Mus musculus)
Mammalia Fxyd4 35
  • 75.49 (n)
  • 67.65 (a)
Fxyd4 16
Fxyd4 36
  • 67 (a)
(Pan troglodytes)
Mammalia FXYD4 35
  • 98.88 (n)
  • 98.88 (a)
FXYD4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fxyd4 35
  • 74.87 (n)
  • 67.69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
Species with no ortholog for FXYD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD4 Gene

Gene Tree for FXYD4 (if available)
Gene Tree for FXYD4 (if available)

Paralogs for FXYD4 Gene

Paralogs for FXYD4 Gene

(1) SIMAP similar genes for FXYD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FXYD4: view

Variants for FXYD4 Gene

Sequence variations from dbSNP and Humsavar for FXYD4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs4245604 -- 43,371,080(+) CCCCA(A/C)AGCTG upstream-variant-2KB
rs4322345 -- 43,370,099(+) CGGGA(C/T)GCCTC upstream-variant-2KB
rs7094556 -- 43,376,551(+) TTCCA(C/T)CACTT downstream-variant-500B
rs4627023 -- 43,370,437(+) GTGCC(C/G)GTAAT upstream-variant-2KB
rs11598898 -- 43,375,390(+) GCTTG(G/T)CTTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FXYD4 Gene

Variant ID Type Subtype PubMed ID
nsv895087 CNV Loss 21882294
nsv831842 CNV Loss 17160897
nsv521283 CNV Loss 19592680

Variation tolerance for FXYD4 Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FXYD4 Gene

Disorders for FXYD4 Gene

Relevant External Links for FXYD4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FXYD4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FXYD4 Gene

Publications for FXYD4 Gene

  1. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PMID: 10950925) Sweadner K.J. … Rael E. (Genomics 2000) 2 3 4 23 67
  2. FXYD proteins as regulators of the Na,K-ATPase in the kidney. (PMID: 12763854) Sweadner K.J. … Wetzel R.K. (Ann. N. Y. Acad. Sci. 2003) 2 3 23
  3. CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit. (PMID: 11483503) BAcguin P. … Geering K. (EMBO J. 2001) 3 23
  4. Genome wide association and linkage analyses identified three loci-4q25, 17q23.2, and 10q11.21-associated with variation in leukocyte telomere length: the Long Life Family Study. (PMID: 24478790) Lee J.H. … Mayeux R. (Front Genet 2013) 3
  5. Nuclear magnetic resonance structural studies of membrane proteins in micelles and bilayers. (PMID: 17951757) Gong X.M. … Marassi F.M. (Methods Mol. Biol. 2007) 23

Products for FXYD4 Gene

Sources for FXYD4 Gene