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Aliases for FXYD4 Gene

Aliases for FXYD4 Gene

  • FXYD Domain Containing Ion Transport Regulator 4 2 3
  • FXYD Domain-Containing Ion Transport Regulator 4 2 3
  • Channel-Inducing Factor 3
  • CHIF 3

External Ids for FXYD4 Gene

Previous GeneCards Identifiers for FXYD4 Gene

  • GC00U990738
  • GC10M043337
  • GC10P043642
  • GC10P043151
  • GC10P043187
  • GC10P043867
  • GC10P040393

Summaries for FXYD4 Gene

Entrez Gene Summary for FXYD4 Gene

  • This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF for channel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as the gamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. Alternatively spliced transcript variants encoding the same protein have been found.[provided by RefSeq, May 2010]

GeneCards Summary for FXYD4 Gene

FXYD4 (FXYD Domain Containing Ion Transport Regulator 4) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include potassium channel activity and ATPase binding. An important paralog of this gene is FXYD3.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD4 Gene

Genomics for FXYD4 Gene

Regulatory Elements for FXYD4 Gene

Genomic Location for FXYD4 Gene

43,371,642 bp from pter
43,376,335 bp from pter
4,694 bases
Plus strand

Genomic View for FXYD4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FXYD4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD4 Gene

Proteins for FXYD4 Gene

  • Protein details for FXYD4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 4
    Protein Accession:
    Secondary Accessions:
    • Q6UWZ1
    • Q7Z4M5

    Protein attributes for FXYD4 Gene

    89 amino acids
    Molecular mass:
    9373 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FXYD4 Gene

Proteomics data for FXYD4 Gene at MOPED

Post-translational modifications for FXYD4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FXYD4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FXYD4 Gene

Domains for FXYD4 Gene

Protein Domains for FXYD4 Gene


Suggested Antigen Peptide Sequences for FXYD4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FXYD family.
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD4: view

No data available for Gene Families for FXYD4 Gene

Function for FXYD4 Gene

Gene Ontology (GO) - Molecular Function for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005267 potassium channel activity IEA --
GO:0005515 protein binding --
GO:0017080 sodium channel regulator activity IBA --
GO:0051117 ATPase binding IEA --
genes like me logo Genes that share ontologies with FXYD4: view
genes like me logo Genes that share phenotypes with FXYD4: view

Animal Models for FXYD4 Gene

MGI Knock Outs for FXYD4:

Animal Model Products

miRNA for FXYD4 Gene

miRTarBase miRNAs that target FXYD4

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FXYD4

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FXYD4 Gene

Localization for FXYD4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FXYD4 Gene COMPARTMENTS Subcellular localization image for FXYD4 gene
Compartment Confidence
plasma membrane 4
extracellular 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with FXYD4: view

Pathways for FXYD4 Gene

genes like me logo Genes that share pathways with FXYD4: view

Pathways by source for FXYD4 Gene

Interacting Proteins for FXYD4 Gene

Gene Ontology (GO) - Biological Process for FXYD4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:0071805 potassium ion transmembrane transport IEA --
GO:2000649 regulation of sodium ion transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with FXYD4: view

Drugs for FXYD4 Gene

(3) Novoseek inferred chemical compound relationships for FXYD4 Gene

Compound -log(P) Hits PubMed IDs
lipid 15.9 1
potassium 8 3
sodium 5.19 2
genes like me logo Genes that share compounds with FXYD4: view

Transcripts for FXYD4 Gene

mRNA/cDNA for FXYD4 Gene

(19) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FXYD4 Gene

FXYD domain containing ion transport regulator 4:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FXYD4

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP2: -

Relevant External Links for FXYD4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD4 Gene

mRNA expression in normal human tissues for FXYD4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD4 Gene

This gene is overexpressed in Kidney - Cortex (42.4).

SOURCE GeneReport for Unigene cluster for FXYD4 Gene Hs.130497

genes like me logo Genes that share expressions with FXYD4: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for FXYD4 Gene

Orthologs for FXYD4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FXYD4 35
  • 78.1 (n)
  • 67.14 (a)
(Canis familiaris)
Mammalia FXYD4 35
  • 82.38 (n)
  • 73.56 (a)
FXYD4 36
  • 72 (a)
(Mus musculus)
Mammalia Fxyd4 35
  • 75.49 (n)
  • 67.65 (a)
Fxyd4 16
Fxyd4 36
  • 67 (a)
(Pan troglodytes)
Mammalia FXYD4 35
  • 98.88 (n)
  • 98.88 (a)
FXYD4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fxyd4 35
  • 74.87 (n)
  • 67.69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 31 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
Species with no ortholog for FXYD4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD4 Gene

Gene Tree for FXYD4 (if available)
Gene Tree for FXYD4 (if available)

Paralogs for FXYD4 Gene

Paralogs for FXYD4 Gene

(1) SIMAP similar genes for FXYD4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FXYD4: view

Variants for FXYD4 Gene

Sequence variations from dbSNP and Humsavar for FXYD4 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs4245604 -- 43,371,080(+) CCCCA(A/C)AGCTG upstream-variant-2KB
rs4322345 -- 43,370,099(+) CGGGA(C/T)GCCTC upstream-variant-2KB
rs4627023 -- 43,370,437(+) GTGCC(C/G)GTAAT upstream-variant-2KB
rs4948564 -- 43,376,550(+) TTTCC(A/G)CCACT downstream-variant-500B
rs6593513 -- 43,376,514(+) TGAGA(C/T)ACCAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FXYD4 Gene

Variant ID Type Subtype PubMed ID
nsv895087 CNV Loss 21882294
nsv831842 CNV Loss 17160897
nsv521283 CNV Loss 19592680

Relevant External Links for FXYD4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD4 Gene

Disorders for FXYD4 Gene

No disorders were found for FXYD4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FXYD4 Gene

Publications for FXYD4 Gene

  1. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PMID: 10950925) Sweadner K.J. … Rael E. (Genomics 2000) 2 3 4 23
  2. FXYD proteins as regulators of the Na,K-ATPase in the kidney. (PMID: 12763854) Sweadner K.J. … Wetzel R.K. (Ann. N. Y. Acad. Sci. 2003) 2 3 23
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FXYD4 Gene

Sources for FXYD4 Gene

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