FXYD4 Gene
protein-coding GIFtS: 48
GCID: GC10P043867
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FXYD domain containing ion transport regulator 4(Previous name: FXYD domain-containing ion transport regulator 4 )
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Aliases
for FXYD4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FXYD Domain Containing Ion Transport Regulator 41 2 | | CHIF1 2 | | FXYD Domain-Containing Ion Transport Regulator 41 2 | | Channel-Inducing Factor2 |
Export aliases for FXYD4 gene to outside databasesPrevious GC identifers: GC00U990738 GC10M043337 GC10P043642 GC10P043151 GC10P043187 GC10P040393 |
Summaries
for FXYD4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FXYD4:
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain,beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved humangene nomenclature for the family is FXYD-domain containing ion transport regulator. FXYD4, originally named CHIF forchannel-inducing factor, has been shown to modulate the properties of the Na,K-ATPase, as has FXYD2, also known as thegamma subunit of the Na,K-ATPase, and FXYD7. Transmembrane topology has been established for FXYD4 and two familymembers (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of themembrane. Alternatively spliced transcript variants encoding the same protein have been found.(provided by RefSeq, May2010)
|
Genomic Views
for FXYD4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_018921.1 NC_000010.10 NT_033985.7
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FXYD4 gene promoter:
GR Spz1 Pbx1a Pax-5 GR-beta PPAR-alpha AREB6 GR-alpha Pax-4a En-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FXYD4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXYD4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q11.21 Ensembl cytogenetic band: 10q11.21 HGNC cytogenetic band: 10q11.21FXYD4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P043867: view genomic region
(about GC identifiers)
Start:
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43,867,090 bp from pter |
End:
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43,871,783 bp from pter |
Size:
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4,694 bases |
Orientation:
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plus strand |
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Proteins
for FXYD4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FXYD4_HUMAN, P59646 (See
protein sequence)Recommended Name: FXYD domain-containing ion transport regulator 4 precursor Size: 89 amino acids; 9373 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: Q6UWZ1 Q7Z4M5Explore the universe of human proteins at neXtProt for FXYD4: NX_P59646
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P59646
FXYD4 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins (2 alternative transcripts):
NP_001171892.1 NP_775183.1
ENSEMBL proteins: ENSP00000363575 ENSP00000388004 Reactome Protein details: P59646
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005792 | microsome |
-- | -- | | GO:0016021 | integral to membrane |
IEA | -- |
FXYD4 for ontologies About GeneDecksing
FXYD4 Antibody Products:
Assay Products for FXYD4: |
Protein
Domains /
Families
for FXYD4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FXYD4 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P59646ProtoNet protein and cluster: P59646 1 Blocks protein family: IPB000272 FXYD protein
UniProtKB/Swiss-Prot: FXYD4_HUMAN, P59646Similarity: Belongs to the FXYD family |
Function
for FXYD4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD4 (see all 3)
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD4 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
FXYD4 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FXYD4:
Animal Models:
Mouse knock-outs for FXYD4: Fxyd4tm1Grt Fxyd4tm1Lex
4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Fxyd4):
FXYD4 for phenotypes About GeneDecksing
|
Pathways & Interactions
for FXYD4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ion channel transport | | | 2 | Aldosterone-regulated sodium reabsorption | | | 3 | SLC-mediated transmembrane transport | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for FXYD4
1 
Kegg Pathway (Kegg details for FXYD4):
FXYD4 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FXYD4
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0071805 | potassium ion transmembrane transport |
-- | -- |
FXYD4 for ontologies About GeneDecksing
|
Drugs & Compounds
for FXYD4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FXYD4 for compounds About GeneDecksing
 Browse Tocris compounds for FXYD4
3 Novoseek chemical compound relationships for FXYD4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lipid |
15.9 |
3 |
18098352 (1) |
| potassium |
8 |
8 |
10793021 (3) |
| sodium |
5.19 |
2 |
12763861 (2) |
Search CenterWatch for drugs/clinical trials and news about FXYD4
|
Transcripts
for FXYD4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FXYD4 gene (2 alternative transcripts): NM_001184963.1 NM_173160.2 Unigene Cluster for FXYD4: FXYD domain containing ion transport regulator 4 Hs.130497 [show with all ESTs]Unigene Representative Sequence: BG4262215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000476166 ENST00000374451 ENST00000480834 ENST00000479189 ENST00000458363(uc001jaq.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD4 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD4 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FXYD4 (NM_001184963) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FXYD4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXYD4 |
Additional cDNA sequence: AY358584.1 BC054876.1 2 DOTS entries: DT.95358099 DT.102707 19 AceView cDNA sequences: BX089155 AI003791 NM_173160 AI792356 AI733634 AI733510 BF507928 AI792219 AI829935 AY358584 AI050782 BC054876 AI262253 AA759244 BG432244 AI350899 AW242333 AI469331 BG426221
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for FXYD4 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FXYD4
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Expression
for FXYD4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FXYD4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGAGTGA
About this image
Genevestigator expression for FXYD4
SOURCE GeneReport for Unigene cluster: Hs.130497
SABiosciences Custom PCR Arrays for FXYD4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FXYD4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FXYD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXYD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXYD4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD4 |
Orthologs
for FXYD4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FXYD4 gene from 2/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
48(a) |
1 → many |
GL343276.1(122495-132852) |
zebrafish
(Danio rerio) |
Actinopterygii |
fxyd66 |
FXYD domain containing ion transport regulator 6 |
26(a) |
1 → many |
15(13143100-13188287) |
ENSEMBL Gene Tree for FXYD4 (if available)
TreeFam Gene Tree for FXYD4 (if available) |
Paralogs
for FXYD4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FXYD4 gene
- FXYD32
1 SIMAP similar gene for FXYD4 using alignment to 1 protein entry: FXYD4_HUMAN:FXYD3
FXYD4 for paralogs About GeneDecksing
|
Genomic Variants
for FXYD4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FXYD4 (43867090 - 43871783 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FXYD4: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FXYD4 |
|
Disorders
/ Diseases
for FXYD4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FXYD4 for disorders About GeneDecksing
1  disease for FXYD4: About MalaCardsaldosteronism
Export disorders for FXYD4 gene to outside databases
|
Publications
for FXYD4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FXYD4 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with FXYD4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PubMed id 10950925)1, 2, 3, 9 Sweadner K.J. and Rael E. (2000)
- FXYD proteins as regulators of the Na,K-ATPase in the kidney. (PubMed id 12763854)1, 3, 9 Sweadner K.J....Wetzel R.K. (2003)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)1, 2 Deloukas P.... Rogers J. (2004)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- CHIF, a member of the FXYD protein family, is a regulator of Na,K-ATPase distinct from the gamma-subunit. (PubMed id 11483503)1, 9 Beguin P....Geering K. (2001)
- Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers. (PubMed id 12535606)1 Crowell K.J....Marassi F.M. (2003)
- A functional interaction between CHIF and Na-K-ATPase: implication for regulation by FXYD proteins. (PubMed id 12217851)1 Garty H....Karlish S.J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Possible molecular basis for changes in potassium handling in acute renal failure. (PubMed id 10793021)9 Rabb H....Soleimani M. (2000)
|
External Searches for FXYD4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FXYD4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FXYD4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FXYD4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FXYD4 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FXYD4 gene:
Search GeneIP for patents involving FXYD4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FXYD4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FXYD4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FXYD4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FXYD4 | | | OriGene Protein Over-expression Lysate for FXYD4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FXYD4 | | OriGene 3'-UTR Clone for FXYD4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FXYD4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FXYD4 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FXYD4 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXYD4 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FXYD4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXYD4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXYD4 |
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| |  |  |  |  | | | | |
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 | | | FXYD4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD4 |
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