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Aliases for FXYD3 Gene

Aliases for FXYD3 Gene

  • FXYD Domain Containing Ion Transport Regulator 3 2 3
  • PLML 3 4 6
  • MAT8 3 4 6
  • FXYD Domain-Containing Ion Transport Regulator 3 2 3
  • Chloride Conductance Inducer Protein Mat-8 3 4
  • Mammary Tumor 8 KDa Protein 3 4
  • Phospholemman-Like Protein 3
  • Phospholemman-Like 4

External Ids for FXYD3 Gene

Previous HGNC Symbols for FXYD3 Gene

  • PLML

Previous GeneCards Identifiers for FXYD3 Gene

  • GC19P036224
  • GC19P036055
  • GC19P040282
  • GC19P040298
  • GC19P035606
  • GC19P032114

Summaries for FXYD3 Gene

Entrez Gene Summary for FXYD3 Gene

  • This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for FXYD3 Gene

FXYD3 (FXYD Domain Containing Ion Transport Regulator 3) is a Protein Coding gene. Among its related pathways are Ion channel transport and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is FXYD4.

UniProtKB/Swiss-Prot for FXYD3 Gene

  • Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels

Gene Wiki entry for FXYD3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD3 Gene

Genomics for FXYD3 Gene

Regulatory Elements for FXYD3 Gene

Transcription factor binding sites by QIAGEN in the FXYD3 gene promoter:

Genomic Location for FXYD3 Gene

35,115,828 bp from pter
35,124,324 bp from pter
8,497 bases
Plus strand

Genomic View for FXYD3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FXYD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD3 Gene

Proteins for FXYD3 Gene

  • Protein details for FXYD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 3
    Protein Accession:
    Secondary Accessions:
    • A6NDE0
    • C9JDU2
    • F5H174
    • F8WB34
    • Q13211
    • Q6IB59

    Protein attributes for FXYD3 Gene

    87 amino acids
    Molecular mass:
    9263 Da
    Quaternary structure:
    No Data Available
    • Marker of a cell type preferentially transformed by neu or ras oncoprotein

    Alternative splice isoforms for FXYD3 Gene


neXtProt entry for FXYD3 Gene

Proteomics data for FXYD3 Gene at MOPED

Post-translational modifications for FXYD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FXYD3 Gene

Domains for FXYD3 Gene

Protein Domains for FXYD3 Gene


Suggested Antigen Peptide Sequences for FXYD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14802
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD3: view

No data available for Gene Families for FXYD3 Gene

Function for FXYD3 Gene

Molecular function for FXYD3 Gene

UniProtKB/Swiss-Prot Function: Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels

Gene Ontology (GO) - Molecular Function for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005216 ion channel activity --
GO:0005254 chloride channel activity IEA --
GO:0005515 protein binding --
GO:0017080 sodium channel regulator activity IBA --
GO:0051117 ATPase binding IEA --
genes like me logo Genes that share ontologies with FXYD3: view

Phenotypes for FXYD3 Gene

genes like me logo Genes that share phenotypes with FXYD3: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FXYD3 Gene

Localization for FXYD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FXYD3 Gene COMPARTMENTS Subcellular localization image for FXYD3 gene
Compartment Confidence
plasma membrane 4
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7836447
GO:0016020 membrane --
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with FXYD3: view

Pathways for FXYD3 Gene

genes like me logo Genes that share pathways with FXYD3: view

Pathways by source for FXYD3 Gene

Interacting Proteins for FXYD3 Gene

Gene Ontology (GO) - Biological Process for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport --
GO:0006821 chloride transport TAS 7836447
GO:0034220 ion transmembrane transport TAS --
GO:0050790 regulation of catalytic activity IEA --
GO:0055085 transmembrane transport TAS --
genes like me logo Genes that share ontologies with FXYD3: view

Compounds for FXYD3 Gene

(1) HMDB Compounds for FXYD3 Gene

Compound Synonyms Cas Number PubMed IDs
  • Cl2

(1) Novoseek inferred chemical compound relationships for FXYD3 Gene

Compound -log(P) Hits PubMed IDs
chloride 47.1 4
genes like me logo Genes that share compounds with FXYD3: view

Transcripts for FXYD3 Gene

Unigene Clusters for FXYD3 Gene

FXYD domain containing ion transport regulator 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - -
SP3: -
SP4: - - -
SP6: -

Relevant External Links for FXYD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD3 Gene

mRNA expression in normal human tissues for FXYD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD3 Gene

This gene is overexpressed in Colon - Transverse (17.9) and Esophagus - Mucosa (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FXYD3 Gene

SOURCE GeneReport for Unigene cluster for FXYD3 Gene Hs.301350

mRNA Expression by UniProt/SwissProt for FXYD3 Gene

Tissue specificity: Expressed in a subset of human breast tumors
genes like me logo Genes that share expressions with FXYD3: view

Orthologs for FXYD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FXYD3 36
  • 98 (a)
(Bos Taurus)
Mammalia FXYD3 36
  • 76 (a)
(Canis familiaris)
Mammalia FXYD3 35
  • 83.14 (n)
  • 71.26 (a)
FXYD3 36
  • 70 (a)
(Mus musculus)
Mammalia Fxyd3 35
  • 76.25 (n)
  • 73.56 (a)
Fxyd3 16
Fxyd3 36
  • 73 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
(Rattus norvegicus)
Mammalia Fxyd3 35
  • 76.63 (n)
  • 73.56 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fxyd3 35
  • 58.91 (n)
  • 51.16 (a)
Species with no ortholog for FXYD3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD3 Gene

Gene Tree for FXYD3 (if available)
Gene Tree for FXYD3 (if available)

Paralogs for FXYD3 Gene

Paralogs for FXYD3 Gene

Selected SIMAP similar genes for FXYD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FXYD3: view

Variants for FXYD3 Gene

Sequence variations from dbSNP and Humsavar for FXYD3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4835 -- 35,123,630(+) TTTTT(A/T)ATCTA utr-variant-3-prime, downstream-variant-500B
rs897761 -- 35,115,568(+) AGTGC(A/T)GGGGG upstream-variant-2KB
rs897762 -- 35,116,093(+) CAGGG(A/G)CCGAG intron-variant, upstream-variant-2KB
rs921936 -- 35,123,344(+) ACACG(C/G)AAGTG intron-variant, downstream-variant-500B
rs937088 -- 35,123,368(+) TGTGT(A/G)TGTGT intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FXYD3 Gene

Variant ID Type Subtype PubMed ID
dgv3849n71 CNV Loss 21882294
nsv911617 CNV Loss 21882294
esv259532 OTHER Complex 20981092
nsv138264 CNV Insertion 16902084
esv1002416 CNV Insertion 20482838
esv1471418 CNV Insertion 17803354
nsv138054 CNV Insertion 16902084
nsv137954 CNV Loss 16902084
nsv819858 CNV Loss 19587683

Relevant External Links for FXYD3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD3 Gene

Disorders for FXYD3 Gene

(3) Novoseek inferred disease relationships for FXYD3 Gene

Disease -log(P) Hits PubMed IDs
mammary tumor 56.1 3
adenocarcinoma 13.8 2
tumors 9.2 6
genes like me logo Genes that share disorders with FXYD3: view

No data available for UniProtKB/Swiss-Prot for FXYD3 Gene

Publications for FXYD3 Gene

  1. Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. (PMID: 7836447) Morrison B.W. … Leder P. (J. Biol. Chem. 1995) 2 3 4 23
  2. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PMID: 10950925) Sweadner K.J. … Rael E. (Genomics 2000) 2 3 23
  3. FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth. (PMID: 16003754) Kayed H. … Friess H. (Int. J. Cancer 2006) 3 23
  4. Structural and functional properties of two human FXYD3 (Mat-8) isoforms. (PMID: 17077088) Bibert S. … Geering K. (J. Biol. Chem. 2006) 3 23
  5. A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells. (PMID: 19109419) Bibert S. … Geering K. (Mol. Biol. Cell 2009) 3 23

Products for FXYD3 Gene

Sources for FXYD3 Gene

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