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Aliases for FXYD3 Gene

Aliases for FXYD3 Gene

  • FXYD Domain Containing Ion Transport Regulator 3 2 3 5
  • FXYD Domain-Containing Ion Transport Regulator 3 2 3
  • Chloride Conductance Inducer Protein Mat-8 3 4
  • Mammary Tumor 8 KDa Protein 3 4
  • PLML 3 4
  • MAT8 3 4
  • Phospholemman-Like Protein 3
  • Phospholemman-Like 4

External Ids for FXYD3 Gene

Previous HGNC Symbols for FXYD3 Gene

  • PLML

Previous GeneCards Identifiers for FXYD3 Gene

  • GC19P036224
  • GC19P036055
  • GC19P040282
  • GC19P040298
  • GC19P035606
  • GC19P032114

Summaries for FXYD3 Gene

Entrez Gene Summary for FXYD3 Gene

  • This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for FXYD3 Gene

FXYD3 (FXYD Domain Containing Ion Transport Regulator 3) is a Protein Coding gene. Among its related pathways are Cardiac conduction and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include ion channel activity and ATPase binding. An important paralog of this gene is FXYD4.

UniProtKB/Swiss-Prot for FXYD3 Gene

  • Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.

Gene Wiki entry for FXYD3 Gene

Additional gene information for FXYD3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD3 Gene

Genomics for FXYD3 Gene

Regulatory Elements for FXYD3 Gene

Enhancers for FXYD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H034972 2 FANTOM5 Ensembl ENCODE dbSUPER 14.9 -141.8 -141755 2.5 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF302 ZNF416 ZNF207 TMEM147-AS1 LSM14A PROSER3 ZNF599 ENSG00000267049 HAUS5 KIAA0355 ZNF181 KMT2B ZNF30
GH19H035113 1.8 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +2.2 2204 8.1 ZNF2 ZBTB7B TCF12 GLIS2 ZNF143 FOS KLF7 ATF7 SP3 REST LSM14A RBM42 PROSER3 KIAA0355 LINC01766 KMT2B ENSG00000221857 LINC00904 ENSG00000270544 ENSG00000271171
GH19H035202 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +89.7 89726 6.1 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF766 CBX5 ZNF143 ZNF207 FOS ZNF599 KIAA0355 FXYD5 TMEM147-AS1 HAUS5 ZNF792 USF2 ENSG00000271049 FAM187B LSR
GH19H035136 1.3 ENCODE dbSUPER 12.6 +23.6 23642 5.4 HDGF FOXA2 MLX ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143 ZNF548 ZNF599 TMEM147-AS1 LSM14A HAUS5 KIAA0355 ZNF792 KMT2B RBM42 PROSER3 ENSG00000221857
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FXYD3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FXYD3 gene promoter:

Genomic Locations for FXYD3 Gene

Genomic Locations for FXYD3 Gene
8,509 bases
Plus strand

Genomic View for FXYD3 Gene

Genes around FXYD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD3 Gene

Proteins for FXYD3 Gene

  • Protein details for FXYD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FXYD domain-containing ion transport regulator 3
    Protein Accession:
    Secondary Accessions:
    • A6NDE0
    • C9JDU2
    • F5H174
    • F8WB34
    • Q13211
    • Q6IB59

    Protein attributes for FXYD3 Gene

    87 amino acids
    Molecular mass:
    9263 Da
    Quaternary structure:
    No Data Available
    • Marker of a cell type preferentially transformed by neu or ras oncoprotein.

    Alternative splice isoforms for FXYD3 Gene


neXtProt entry for FXYD3 Gene

Post-translational modifications for FXYD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FXYD3 Gene

Domains & Families for FXYD3 Gene

Gene Families for FXYD3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for FXYD3 Gene

Suggested Antigen Peptide Sequences for FXYD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FXYD family.
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD3: view

Function for FXYD3 Gene

Molecular function for FXYD3 Gene

UniProtKB/Swiss-Prot Function:
Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.

Gene Ontology (GO) - Molecular Function for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity TAS 7836447
GO:0017080 sodium channel regulator activity IBA --
genes like me logo Genes that share ontologies with FXYD3: view
genes like me logo Genes that share phenotypes with FXYD3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FXYD3 Gene

Localization for FXYD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FXYD3 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7836447
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with FXYD3: view

Pathways & Interactions for FXYD3 Gene

genes like me logo Genes that share pathways with FXYD3: view

Pathways by source for FXYD3 Gene

Gene Ontology (GO) - Biological Process for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006813 potassium ion transport IEA --
GO:0006814 sodium ion transport IEA --
GO:0006821 chloride transport TAS 7836447
genes like me logo Genes that share ontologies with FXYD3: view

No data available for SIGNOR curated interactions for FXYD3 Gene

Drugs & Compounds for FXYD3 Gene

(2) Additional Compounds for FXYD3 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with FXYD3: view

Transcripts for FXYD3 Gene

Unigene Clusters for FXYD3 Gene

FXYD domain containing ion transport regulator 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - -
SP3: -
SP4: - - -
SP6: -

Relevant External Links for FXYD3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FXYD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD3 Gene

This gene is overexpressed in Colon - Transverse (x17.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for FXYD3 Gene

This gene is overexpressed in Nasal epithelium (23.5), Colon (15.5), and Rectum (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FXYD3 Gene

Protein tissue co-expression partners for FXYD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FXYD3 Gene:


SOURCE GeneReport for Unigene cluster for FXYD3 Gene:


mRNA Expression by UniProt/SwissProt for FXYD3 Gene:

Tissue specificity: Expressed in a subset of human breast tumors.

Evidence on tissue expression from TISSUES for FXYD3 Gene

  • Intestine(4.3)
  • Nervous system(3.7)
  • Stomach(2.9)
  • Lung(2.7)
  • Skin(2.4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with FXYD3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FXYD3 Gene

Orthologs for FXYD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FXYD3 34
  • 98 (a)
(Canis familiaris)
Mammalia FXYD3 33 34
  • 83.14 (n)
(Rattus norvegicus)
Mammalia Fxyd3 33
  • 76.63 (n)
(Mus musculus)
Mammalia Fxyd3 33 16 34
  • 76.25 (n)
(Bos Taurus)
Mammalia FXYD3 34
  • 76 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 58 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fxyd3 33
  • 58.91 (n)
Species where no ortholog for FXYD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD3 Gene

Gene Tree for FXYD3 (if available)
Gene Tree for FXYD3 (if available)

Paralogs for FXYD3 Gene

Paralogs for FXYD3 Gene

(6) SIMAP similar genes for FXYD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FXYD3: view

Variants for FXYD3 Gene

Sequence variations from dbSNP and Humsavar for FXYD3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000010331 -- 35,119,553(+) TAAGA(A/G)AAGTC intron-variant
rs1000019965 -- 35,114,459(+) CCTCT(A/C)CAGAA upstream-variant-2KB
rs1000125248 -- 35,114,117(+) TTGGA(C/T)GCAGC upstream-variant-2KB
rs1000187675 -- 35,115,360(+) GACCC(C/G/T)AATCC upstream-variant-2KB
rs1000253211 -- 35,124,699(+) GAGGG(A/G)AACCC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FXYD3 Gene

Variant ID Type Subtype PubMed ID
nsv819858 CNV loss 19587683
nsv138264 CNV insertion 16902084
nsv138054 CNV insertion 16902084
nsv137954 CNV deletion 16902084
esv3381956 CNV insertion 20981092
esv3302558 CNV tandem duplication 20981092
esv1471418 CNV insertion 17803354
esv1002416 CNV insertion 20482838
dgv1773n106 CNV tandem duplication 24896259

Variation tolerance for FXYD3 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FXYD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD3 Gene

Disorders for FXYD3 Gene

Relevant External Links for FXYD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FXYD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FXYD3 Gene

Publications for FXYD3 Gene

  1. Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. (PMID: 7836447) Morrison BW … Leder P (The Journal of biological chemistry 1995) 2 3 4 22 60
  2. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PMID: 10950925) Sweadner KJ … Rael E (Genomics 2000) 2 3 22 60
  3. Expression and significance of FXYD-3 protein in gastric adenocarcinoma. (PMID: 20364041) Zhu ZL … Sun XF (Disease markers 2010) 3 22 60
  4. A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells. (PMID: 19109419) Bibert S … Geering K (Molecular biology of the cell 2009) 3 22 60
  5. FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues. (PMID: 19571376) Yamamoto H … Asano S (Biological & pharmaceutical bulletin 2009) 3 22 60

Products for FXYD3 Gene

Sources for FXYD3 Gene

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