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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FXYD3 Gene

protein-coding   GIFtS: 55
GCID: GC19P035606

FXYD domain containing ion transport regulator 3

(Previous name: FXYD domain-containing ion transport regulator 3 )
(Previous symbol: PLML)
 Explore 13 diseases affiliated with
FXYD3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FXYD3    

Aliases
for FXYD3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
FXYD Domain Containing Ion Transport Regulator 31 2     Mammary Tumor 8 KDa Protein2 3
PLML1 2 3 5     MAT-81
MAT82 3 5     Phospholemman-Like Protein2
FXYD Domain-Containing Ion Transport Regulator 31 2     Phospholemman-Like1
Chloride Conductance Inducer Protein Mat-82 3     

External Ids:    HGNC: 40271   Entrez Gene: 53492   Ensembl: ENSG000000893567   OMIM: 6049965   UniProtKB: Q148023   

Export aliases for FXYD3 gene to outside databases

Previous GC identifers: GC19P036224 GC19P036055 GC19P040282 GC19P040298 GC19P032114


Summaries
for FXYD3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FXYD3:
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid
signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino
acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This
gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding
distinct isoforms.(provided by RefSeq, Oct 2008)

UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802
Function: Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator
capable of activating endogenous oocyte channels

Gene Wiki entry for FXYD3


Genomic Views
for FXYD3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FXYD3 gene promoter:
         p53   FOXO4   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FXYD3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FXYD3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXYD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.11-q13.12

FXYD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035606:  view genomic region     (about GC identifiers)

Start:
 35,606,732 bp from pter      End:
 35,615,228 bp from pter
Size:
 8,497 bases      Orientation:
 plus strand

Proteins
for FXYD3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802 (See protein sequence)
Recommended Name: FXYD domain-containing ion transport regulator 3 precursor  
Size: 87 amino acids; 9263 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Miscellaneous: Marker of a cell type preferentially transformed by neu or ras oncoprotein
Secondary accessions: A6NDE0 F5H174 Q13211 Q6IB59
Alternative splicing: 3 isoforms:  Q14802-1   Q14802-2   Q14802-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FXYD3: NX_Q14802

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14802

    • FXYD3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (8 alternative transcripts): 
    NP_001129479.1  NP_001129480.1  NP_001129481.1  NP_001129482.1  NP_001129483.1  NP_001129484.1  NP_005962.1  NP_068710.1  

    ENSEMBL proteins: 
     ENSP00000389770   ENSP00000443953   ENSP00000328259   ENSP00000339499   ENSP00000385200  
     ENSP00000385412   ENSP00000415449  
    Reactome Protein details: Q14802
    Human Recombinant Protein Products: 
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    OriGene Purified Proteins (see all 3): FXYD3
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    Novus Biologicals FXYD3 Protein
    Novus Biologicals FXYD3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FXYD3

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane ----
    GO:0005792microsome ----
    GO:0005887integral to plasma membrane TAS7836447
    GO:0016020membrane ----
    GO:0034707chloride channel complex IEA--


    FXYD3 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FXYD3

    Protein Domains /
    Families
    for FXYD3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FXYD3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR000272 Ion-transport_regulator_FXYD

    Graphical View of Domain Structure for InterPro Entry Q14802

    ProtoNet protein and cluster: Q14802

    1 Blocks protein family: IPB000272 FXYD protein

    UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802
    Similarity: Belongs to the FXYD family


    Function
    for FXYD3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802
    Function: Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator
    capable of activating endogenous oocyte channels

    miRNA
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    hsa-miR-2052 hsa-miR-143 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FXYD3 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for FXYD3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD3

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005254chloride channel activity IEA--
    GO:0005515protein binding ----
    GO:0051117ATPase binding ----


    FXYD3 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for FXYD3:
     Decreased POU5F1-GFP protein e  Decreased cilium length after  


    Pathways & Interactions
    for FXYD3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ion channel transport
    		Ion channel transport1.00
    		Ion transport by P-type ATPases0.32
    2SLC-mediated transmembrane transport
    		Transmembrane transport of small molecules0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for FXYD3
        Transmembrane transport of small molecules
    Ion channel transport
    Ion transport by P-type ATPases



    FXYD3 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FXYD3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/10 Interacting proteins for FXYD3 (Q148022, 3 ENSP000003897704) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXL12Q9NXK82, 3, ENSP000002479774MINT-65659 I2D: score=5 STRING: ENSP00000247977
    SERBP1Q8NC512, 3, ENSP000003600344MINT-64987 I2D: score=4 STRING: ENSP00000360034
    MAPK6Q166592, 3MINT-8261142 I2D: score=2 
    NUDT3O959892, 3MINT-8264776 I2D: score=2 
    NR4A1P227363, ENSP000002430504I2D: score=4 STRING: ENSP00000243050
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006821chloride transport TAS7836447
    GO:0050790regulation of catalytic activity ----


    FXYD3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FXYD3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FXYD3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FXYD3

    1 HMDB Compound for FXYD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    1 Novoseek chemical compound relationship for FXYD3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 47.1 5 7836447 (2), 16003754 (1), 7970700 (1)

    Search CenterWatch for drugs/clinical trials and news about FXYD3 

    Transcripts
    for FXYD3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FXYD3 gene (8 alternative transcripts): 
    NM_001136007.1  NM_001136008.1  NM_001136009.1  NM_001136010.1  NM_001136011.1  NM_001136012.1  NM_005971.3  NM_021910.2  

    Unigene Cluster for FXYD3:

    FXYD domain containing ion transport regulator 3
    Hs.301350  [show with all ESTs]
    Unigene Representative Sequence: BF676327
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435734(uc010xsm.2) ENST00000535103 ENST00000346446(uc002nxv.3 uc010xso.2)
    ENST00000344013(uc010xsn.2 uc002nxw.3) ENST00000406988 ENST00000406242(uc010xsl.1)
    ENST00000454903(uc010xsj.1 uc010xsk.1)

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate FXYD3:
    hsa-miR-2052 hsa-miR-143 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmid: FXYD3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FXYD3 (see all 7)
    OriGene shRNA RFP: FXYD3
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXYD3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXYD3

    Additional cDNA sequence: 

    AK311689.1 BC005238.1 BC090044.1 BT006712.1 CR456945.1 CR542197.1 U28249.1 U31214.1 
    X93036.1 

    20 DOTS entries:

    DT.95273968  DT.92400680  DT.95273991  DT.100791840  DT.100791842  DT.121419693  DT.100791839  DT.95314967 
    DT.100791841  DT.91660605  DT.95273976  DT.99934830  DT.100029277  DT.92468321  DT.100029275  DT.100029278 
    DT.121419691  DT.99991237  DT.121419694  DT.91982526 

    24/287 AceView cDNA sequences (see all 287):

    AI720868 BI792433 BF589682 BU174150 AA297619 BU179637 AI949491 BM856416 
    BU185141 BM764603 AI333205 AI659507 AA613779 AA308424 BU157560 AI275995 
    CB113225 AI276743 AA315528 AW629598 BM795648 BM824275 BG982631 BM788242 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FXYD3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                      -           -                                             
    SP2:                    -                             -                                             
    SP3:                                                  -                                             
    SP4:                    -                 -           -                                             
    SP5:                                                                                                


    ECgene alternative splicing isoforms for FXYD3

    Expression
    for FXYD3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FXYD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAGGGCCTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FXYD3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Extraembryonic endoderm-like cells (Generation of extrae...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FXYD3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FXYD3

    SOURCE GeneReport for Unigene cluster: Hs.301350

    UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802
    Tissue specificity: Expressed in a subset of human breast tumors

        SABiosciences Custom PCR Arrays for FXYD3
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    In Situ
    Assay Products:     
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    Orthologs
    for FXYD3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for FXYD3 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 47(a)
    		 1 → many
    		 GL343276.1(122495-132852)
    zebrafish
    (Danio rerio)    		 Actinopterygii fxyd66
    		 FXYD domain containing ion transport regulator 6
    		 26(a)
    		 1 → many
    		 15(13143100-13188287)


    ENSEMBL Gene Tree for FXYD3 (if available)
    TreeFam Gene Tree for FXYD3 (if available) 

    Paralogs
    for FXYD3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FXYD3 gene
    FXYD42  
    6 SIMAP similar genes for FXYD3 using alignment to 3 protein entries:     FXYD3_HUMAN (see all proteins):
    FXYD4    FXYD1    FXYD2    FXYD6    FXYD6P3    FXYD7

    FXYD3 for paralogs           About GeneDecksing



    Genomic Variants
    for FXYD3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/245 NCBI SNPs in FXYD3 are shown (see all 245)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1843239551,2
    		--35604818(+) ACCTAC/TATGCA 8 -- us2k10--------
    rs16729881,2
    		C,H,--35604819(+) CCTACG/ATGCAT 8 -- us2k113Minor allele frequency- A:0.00NS EA NA WA CSA 783
    rs37870371,2
    		C,F,A,H,--35604873(-) AGGTCT/CCATTT 8 -- us2k125Minor allele frequency- C:0.21EA NA NS WA 2976
    rs16880381,2
    		C,H,--35604999(+) CCAGCC/GCCAGC 8 -- us2k113Minor allele frequency- G:0.01NA WA CSA EA 261
    rs1885828141,2
    		--35605035(+) TTCACA/GTCCAG 8 -- us2k10--------
    rs1922412971,2
    		--35605093(+) GTCTGC/TACCTC 8 -- us2k10--------
    rs2020735681,2
    		--35605213(+) GCAAA-/TTTTTT 8 -- us2k10--------
    rs16880391,2
    		C,F,A,H,--35605223(+) TTTTTA/TAATCT 8 -- us2k1 tfbs313Minor allele frequency- T:0.35NA NS EA WA 770
    rs1843901491,2
    		--35605251(+) TTAAAC/TCCCTT 8 -- us2k10--------
    rs1904141721,2
    		--35605258(+) CCTTTA/GAGGTA 8 -- us2k10--------

    HapMap Linkage Disequilibrium report for FXYD3 (35606732 - 35615228 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 2 variations for FXYD3
         2 Indels: 58870 12024

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    Disorders / Diseases
    for FXYD3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FXYD3 for disorders           About GeneDecksing

    OMIM gene information: 604996    OMIM disorders: --

    13 diseases for FXYD3:    About MalaCards
    pancreatic ductal adenocarcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma    adenocarcinoma
    pancreatitis    pancreatic cancer    prostate carcinoma    colorectal cancer
    prostatitis    prostate cancer    breast cancer    melanoma
    carcinoma

    3 Novoseek disease relationships for FXYD3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 56.1 3 14745797 (1), 19571376 (1), 7970700 (1)
    adenocarcinoma 13.8 2 16003754 (2)
    tumors 9.2 7 7836447 (3), 20364041 (1), 19893046 (1), 19571376 (1)


    Export disorders for FXYD3 gene to outside databases

    Publications
    for FXYD3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FXYD3 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with FXYD3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. (PubMed id 7836447)1, 2, 3, 9 Morrison B.W....Leder P. (1995)
    2. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PubMed id 10950925)1, 3, 9 Sweadner K.J. and Rael E. (2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Structural and functional properties of two human FXYD3 (Mat-8) isoforms. (PubMed id 17077088)1, 9 Bibert S....Geering K. (2006)
    5. Down-regulation of FXYD3 expression in human lung can cers: its mechanism and potential role in carcinogenesis. (PubMed id 19893046)1, 9 Okudela K....Kitamura H. (2009)
    6. Expression and significance of FXYD-3 protein in gast ric adenocarcinoma. (PubMed id 20364041)1, 9 Zhu Z.L....Sun X.F. (2010)
    7. FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth. (PubMed id 16003754)1, 9 Kayed H....Friess H. (2006)
    8. A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells. (PubMed id 19109419)1, 9 Bibert S....Geering K. (2009)
    9. FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues. (PubMed id 19571376)1, 9 Yamamoto H....Asano S. (2009)
    10. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)

    External Searches for FXYD3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FXYD3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5349 HGNC: 4027 AceView: FXYD3 Ensembl:ENSG00000089356 euGenes: HUgn5349
    ECgene: FXYD3 H-InvDB: FXYD3

    Other Databases showing FXYD3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FXYD3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FXYD3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FXYD3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FXYD3 gene:
    Search GeneIP for patents involving FXYD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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