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FXYD3 Gene

protein-coding   GIFtS: 55
GCID: GC19P035606

FXYD Domain Containing Ion Transport Regulator 3

(Previous name: FXYD domain-containing ion transport regulator 3)
(Previous symbol: PLML)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FXYD Domain Containing Ion Transport Regulator 31 2     Chloride Conductance Inducer Protein Mat-82 3
PLML1 2 3 5     Mammary Tumor 8 KDa Protein2 3
MAT82 3 5     Phospholemman-Like Protein2
FXYD Domain-Containing Ion Transport Regulator 31 2     Phospholemman-like3

External Ids:    HGNC: 40271   Entrez Gene: 53492   Ensembl: ENSG000000893567   OMIM: 6049965   UniProtKB: Q148023   

Export aliases for FXYD3 gene to outside databases

Previous GC identifers: GC19P036224 GC19P036055 GC19P040282 GC19P040298 GC19P032114


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FXYD3 Gene:
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino
acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly
conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and
ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple
transcript variants encoding distinct isoforms.(provided by RefSeq, Oct 2008)

GeneCards Summary for FXYD3 Gene:
FXYD3 (FXYD domain containing ion transport regulator 3) is a protein-coding gene. Diseases associated with FXYD3 include pancreatic ductal adenocarcinoma, and intrahepatic cholangiocarcinoma. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is FXYD4.

UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802
Function: Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a
modulator capable of activating endogenous oocyte channels

Gene Wiki entry for FXYD3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FXYD3 gene promoter:
         p53   FOXO4   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FXYD3 promoter sequence
   Search Chromatin IP Primers for FXYD3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FXYD3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.11-q13.12

FXYD3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035606:  view genomic region     (about GC identifiers)

Start:
35,606,732 bp from pter      End:
35,615,228 bp from pter
Size:
8,497 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802 (See protein sequence)
Recommended Name: FXYD domain-containing ion transport regulator 3 precursor  
Size: 87 amino acids; 9263 Da
Miscellaneous: Marker of a cell type preferentially transformed by neu or ras oncoprotein
Secondary accessions: A6NDE0 C9JDU2 F5H174 F8WB34 Q13211 Q6IB59
Alternative splicing: 5 isoforms:  Q14802-1   Q14802-2   Q14802-3   Q14802-4   Q14802-5   (No experimental confirmation available. Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for FXYD3: NX_Q14802

Explore proteomics data for FXYD3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FXYD3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001129479.1  NP_001129480.1  NP_001129481.1  NP_001129482.1  NP_001129483.1  NP_001129484.1  NP_005962.1  NP_068710.1  

    ENSEMBL proteins: 
     ENSP00000474438   ENSP00000389770   ENSP00000474851   ENSP00000473929   ENSP00000474055  
     ENSP00000474514   ENSP00000475056   ENSP00000474855   ENSP00000474223   ENSP00000474526  
     ENSP00000474622   ENSP00000443953   ENSP00000328259   ENSP00000339499   ENSP00000385200  
     ENSP00000385412   ENSP00000415449  
    Reactome Protein details: Q14802

    FXYD3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000272 Ion-transport_regulator_FXYD

    Graphical View of Domain Structure for InterPro Entry Q14802

    ProtoNet protein and cluster: Q14802

    1 Blocks protein domain: IPB000272 FXYD protein

    UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802
    Similarity: Belongs to the FXYD family


    FXYD3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FXYD3_HUMAN, Q14802
    Function: Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a
    modulator capable of activating endogenous oocyte channels

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005254chloride channel activity IEA--
    GO:0005515protein binding ----
    GO:0051117ATPase binding IEA--
         
    FXYD3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for FXYD3:
     Decreased POU5F1-GFP protein e  Decreased cilium length after  

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FXYD3
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    3 qRT-PCR Assays for microRNAs that regulate FXYD3:
    hsa-miR-2052 hsa-miR-143 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidFXYD3 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FXYD3

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    GenScript: all cDNA clones in your preferred vector (see all 8): FXYD3 (NM_005971)
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FXYD3_HUMAN, Q14802: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum1
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS7836447
    GO:0016020membrane ----
    GO:0034707chloride channel complex IEA--

    FXYD3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FXYD3 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Ion transport by P-type ATPases
    Ion transport by P-type ATPases

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for FXYD3
        Ion transport by P-type ATPases



    FXYD3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FXYD3
    Interactions:

        GeneGlobe Interaction Network for FXYD3

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for FXYD3 (Q148022, 3 ENSP000003897704) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FBXL12Q9NXK82, 3, ENSP000002479774MINT-65659 I2D: score=5 STRING: ENSP00000247977
    SERBP1Q8NC512, 3, ENSP000003600344MINT-64987 I2D: score=4 STRING: ENSP00000360034
    MAPK6Q166592, 3MINT-8261142 I2D: score=2 
    NUDT3O959892, 3MINT-8264776 I2D: score=2 
    NR4A1P227363, ENSP000002430504I2D: score=4 STRING: ENSP00000243050
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006821chloride transport TAS7836447
    GO:0034220ion transmembrane transport TAS--
    GO:0050790regulation of catalytic activity IEA--
    GO:0055085transmembrane transport TAS--

    FXYD3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FXYD3

    1 HMDB Compound for FXYD3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--

    1 Novoseek inferred chemical compound relationship for FXYD3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloride 47.1 5 7836447 (2), 16003754 (1), 7970700 (1)



    FXYD3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FXYD3 gene (8 alternative transcripts): 
    NM_001136007.1  NM_001136008.1  NM_001136009.1  NM_001136010.1  NM_001136011.1  NM_001136012.1  NM_005971.3  NM_021910.2  

    Unigene Cluster for FXYD3:

    FXYD domain containing ion transport regulator 3
    Hs.301350  [show with all ESTs]
    Unigene Representative Sequence: BF676327
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000604404 ENST00000435734(uc010xsm.2) ENST00000603181 ENST00000604255
    ENST00000604504 ENST00000603449 ENST00000605550 ENST00000604804 ENST00000605552
    ENST00000603524 ENST00000604621 ENST00000605677 ENST00000535103 ENST00000346446(uc002nxv.3 uc010xso.2)
    ENST00000344013(uc010xsn.2 uc002nxw.3) ENST00000406988 ENST00000406242(uc010xsl.1)
    ENST00000454903(uc010xsj.1 uc010xsk.1)
    miRNA
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    hsa-miR-2052 hsa-miR-143 hsa-miR-342-3p
    SwitchGear 3'UTR luciferase reporter plasmidFXYD3 3' UTR sequence
    Inhib. RNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FXYD3
      QuantiTect SYBR Green Assays in human, mouse, rat FXYD3
      QuantiFast Probe-based Assays in human, mouse, rat FXYD3

    Additional mRNA sequence: 

    AK311689.1 BC005238.1 BC090044.1 BT006712.1 CR456945.1 CR542197.1 U28249.1 U31214.1 
    X93036.1 

    20 DOTS entries:

    DT.95273968  DT.92400680  DT.95273991  DT.100791840  DT.100791842  DT.121419693  DT.100791839  DT.95314967 
    DT.100791841  DT.91660605  DT.95273976  DT.99934830  DT.100029277  DT.92468321  DT.100029275  DT.100029278 
    DT.121419691  DT.99991237  DT.121419694  DT.91982526 

    Selected AceView cDNA sequences (see all 287):

    AW250864 BF589682 CB128376 AI949491 AA315528 BU185087 AA297619 BM824275 
    BU185141 BQ431128 AI333205 BM764603 AA613779 AA308424 AW629598 BX476026 
    BQ884244 BG982631 CB160176 BU179637 AI275995 BM856416 AI276743 BI792433 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FXYD3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:                                      -           -                                             
    SP2:                    -                             -                                             
    SP3:                                                  -                                             
    SP4:                    -                 -           -                                             
    SP5:                                                                                                


    ECgene alternative splicing isoforms for FXYD3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FXYD3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAGGGCCTC
    FXYD3 Expression
    About this image


    FXYD3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Renal Collecting Duct System
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Liver (Hepatobiliary System)
             Mature Mesothelial Cells Hepatic Mesenchyme
     
     Colon (Gastrointestinal Tract)
     
     Lung (Respiratory System)
    FXYD3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FXYD3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301350

    UniProtKB/Swiss-Prot: FXYD3_HUMAN, Q14802
    Tissue specificity: Expressed in a subset of human breast tumors

        Custom PCR Arrays for FXYD3
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXYD3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FXYD3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fxyd31 , 5 FXYD domain-containing ion transport regulator 31, 5 76.25(n)1
    73.56(a)1
      7 (19.29 cM)5
    171781  NM_008557.21  NP_032583.11 
     310681725 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    47(a)
    1 → many
    GL343276.1(106481-134775)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fxyd31 FXYD domain-containing ion transport regulator 3 58.91(n)
    51.16(a)
      733884  NM_001045616.1  NP_001039081.1 


    ENSEMBL Gene Tree for FXYD3 (if available)
    TreeFam Gene Tree for FXYD3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FXYD3 gene
    FXYD42  
    6 SIMAP similar genes for FXYD3 using alignment to 3 protein entries:     FXYD3_HUMAN (see all proteins):
    FXYD4    FXYD1    FXYD6    FXYD2    FXYD6P3    FXYD7

    FXYD3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FXYD3 (see all 288)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs105431151,2
    C--32117967(+) GTGAG-/GACAACAG 8 -- int12Minor allele frequency- GAC:0.00CSA 6
    rs1843239551,2
    --35604818(+) ACCTAC/TATGCA 8 -- us2k10--------
    rs16729881,2
    C,H--35604819(+) CCTACG/ATGCAT 8 -- us2k113Minor allele frequency- A:0.00NS EA NA WA CSA 783
    rs37870371,2
    C,F,A,H--35604873(-) AGGTCT/CCATTT 8 -- us2k125Minor allele frequency- C:0.21EA NA NS WA 2976
    rs16880381,2
    C,H--35604999(+) CCAGCC/GCCAGC 8 -- us2k113Minor allele frequency- G:0.01NA WA CSA EA 261
    rs1885828141,2
    --35605035(+) TTCACA/GTCCAG 8 -- us2k10--------
    rs1922412971,2
    --35605093(+) GTCTGC/TACCTC 8 -- us2k10--------
    rs2020735681,2
    --35605213(+) GCAAA-/TTTTTT 8 -- us2k10--------
    rs16880391,2
    C,F,A,H--35605223(+) TTTTTA/TAATCT 8 -- us2k1 tfbs313Minor allele frequency- T:0.35NA NS EA WA 770
    rs1843901491,2
    --35605251(+) TTAAAC/TCCCTT 8 -- us2k10--------

    HapMap Linkage Disequilibrium report for FXYD3 (35606732 - 35615228 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for FXYD3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1002416CNV Insertion20482838
    nsv138054CNV Insertion16902084
    nsv138264CNV Insertion16902084
    esv1471418CNV Insertion17803354
    nsv911617CNV Loss21882294
    nsv137954CNV Loss16902084
    nsv819858CNV Loss19587683
    dgv3849n71CNV Loss21882294
    esv259532OTHER Complex20981092

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604996    OMIM disorders: --

    14 diseases for FXYD3:    
    About MalaCards
    pancreatic ductal adenocarcinoma    intrahepatic cholangiocarcinoma    cholangiocarcinoma    gastric adenocarcinoma
    pancreatitis    adenocarcinoma    pancreatic cancer    colorectal cancer
    melanoma    prostate cancer    prostatitis    breast cancer
    lung cancer    hepatitis


    FXYD3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for FXYD3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mammary tumor 56.1 3 14745797 (1), 19571376 (1), 7970700 (1)
    adenocarcinoma 13.8 2 16003754 (2)
    tumors 9.2 7 7836447 (3), 20364041 (1), 19893046 (1), 19571376 (1)


    Export disorders for FXYD3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FXYD3 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with FXYD3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. (PubMed id 7836447)1, 2, 3, 9 Morrison B.W....Leder P. (J. Biol. Chem. 1995)
    2. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PubMed id 10950925)1, 3, 9 Sweadner K.J. and Rael E. (Genomics 2000)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Structural and functional properties of two human FXYD3 (Mat-8) isoforms. (PubMed id 17077088)1, 9 Bibert S....Geering K. (J. Biol. Chem. 2006)
    5. Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis. (PubMed id 19893046)1, 9 Okudela K....Kitamura H. (Am. J. Pathol. 2009)
    6. Expression and significance of FXYD-3 protein in gastric adenocarcinoma. (PubMed id 20364041)1, 9 Zhu Z.L....Sun X.F. (Dis. Markers 2010)
    7. FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth. (PubMed id 16003754)1, 9 Kayed H....Friess H. (Int. J. Cancer 2006)
    8. A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells. (PubMed id 19109419)1, 9 Bibert S....Geering K. (Mol. Biol. Cell 2009)
    9. FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues. (PubMed id 19571376)1, 9 Yamamoto H....Asano S. (amp 2009)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5349 HGNC: 4027 AceView: FXYD3 Ensembl:ENSG00000089356 euGenes: HUgn5349
    ECgene: FXYD3 H-InvDB: FXYD3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FXYD3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FXYD3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FXYD3 gene:
    Search GeneIP for patents involving FXYD3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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