Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FXYD3 Gene

Aliases for FXYD3 Gene

  • FXYD Domain Containing Ion Transport Regulator 3 2 3 5
  • FXYD Domain-Containing Ion Transport Regulator 3 2 3
  • Chloride Conductance Inducer Protein Mat-8 3 4
  • Mammary Tumor 8 KDa Protein 3 4
  • PLML 3 4
  • MAT8 3 4
  • Phospholemman-Like Protein 3
  • Phospholemman-Like 4

External Ids for FXYD3 Gene

Previous HGNC Symbols for FXYD3 Gene

  • PLML

Previous GeneCards Identifiers for FXYD3 Gene

  • GC19P036224
  • GC19P036055
  • GC19P040282
  • GC19P040298
  • GC19P035606
  • GC19P032114

Summaries for FXYD3 Gene

Entrez Gene Summary for FXYD3 Gene

  • This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]

GeneCards Summary for FXYD3 Gene

FXYD3 (FXYD Domain Containing Ion Transport Regulator 3) is a Protein Coding gene. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Ion channel transport. GO annotations related to this gene include ion channel activity and ATPase binding. An important paralog of this gene is FXYD4.

UniProtKB/Swiss-Prot for FXYD3 Gene

  • Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.

Gene Wiki entry for FXYD3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD3 Gene

Genomics for FXYD3 Gene

Regulatory Elements for FXYD3 Gene

Enhancers for FXYD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G034972 2 FANTOM5 Ensembl ENCODE dbSUPER 14.9 -141.8 -141755 2.5 HDGF PKNOX1 WRNIP1 ARID4B SIN3A ZNF2 YY1 SLC30A9 ZNF302 ZNF416 TMEM147-AS1 SCN1B LSM14A GRAMD1A ZNF792 KIAA0355 RBM42 KMT2B ENSG00000267049 HAUS5
GH19G035113 2 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +2.2 2204 8.1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 LSM14A KIAA0355 LRFN3 RBM42 ENSG00000267219 LGI4 TMEM147-AS1 FXYD3 HAUS5 ZNF792
GH19G035208 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10.6 +96.6 96609 7.1 CREB3L1 FEZF1 ZNF143 ZNF416 ZNF548 ZNF263 SP3 NFYC TBX21 MEF2D TMEM147-AS1 HAUS5 ZNF792 KMT2B KIAA0355 RBM42 ENSG00000267049 ENSG00000268947 ENSG00000267219 LRFN3
GH19G035202 2 FANTOM5 Ensembl ENCODE dbSUPER 10.7 +89.7 89726 6.1 YBX1 YY1 ZNF143 ZNF416 ZNF548 ZNF263 SP3 NFYC TBX21 MEF2D TMEM147-AS1 RBM42 ZNF792 KIAA0355 HAUS5 KMT2B LRFN3 FXYD5 ENSG00000267049 ENSG00000271049
GH19G035328 1.9 FANTOM5 Ensembl ENCODE dbSUPER 9.3 +215.2 215219 5.1 HDGF FOXA2 PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF302 ZNF416 TMEM147-AS1 MAG KMT2B ZNF792 ZNF146 RBM42 CD22 ENSG00000271032 KRTDAP DMKN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FXYD3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FXYD3 gene promoter:

Genomic Location for FXYD3 Gene

Chromosome:
19
Start:
35,115,816 bp from pter
End:
35,124,324 bp from pter
Size:
8,509 bases
Orientation:
Plus strand

Genomic View for FXYD3 Gene

Genes around FXYD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD3 Gene

Proteins for FXYD3 Gene

  • Protein details for FXYD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14802-FXYD3_HUMAN
    Recommended name:
    FXYD domain-containing ion transport regulator 3
    Protein Accession:
    Q14802
    Secondary Accessions:
    • A6NDE0
    • C9JDU2
    • F5H174
    • F8WB34
    • Q13211
    • Q6IB59

    Protein attributes for FXYD3 Gene

    Size:
    87 amino acids
    Molecular mass:
    9263 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Marker of a cell type preferentially transformed by neu or ras oncoprotein.

    Alternative splice isoforms for FXYD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FXYD3 Gene

Post-translational modifications for FXYD3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FXYD3 Gene

Domains & Families for FXYD3 Gene

Protein Domains for FXYD3 Gene

Suggested Antigen Peptide Sequences for FXYD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14802

UniProtKB/Swiss-Prot:

FXYD3_HUMAN :
  • Belongs to the FXYD family.
Family:
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD3: view

No data available for Gene Families for FXYD3 Gene

Function for FXYD3 Gene

Molecular function for FXYD3 Gene

UniProtKB/Swiss-Prot Function:
Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.

Gene Ontology (GO) - Molecular Function for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005254 chloride channel activity TAS,IEA --
GO:0017080 sodium channel regulator activity IBA --
genes like me logo Genes that share ontologies with FXYD3: view
genes like me logo Genes that share phenotypes with FXYD3: view

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FXYD3 Gene

Localization for FXYD3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FXYD3 gene
Compartment Confidence
plasma membrane 5
extracellular 5

Gene Ontology (GO) - Cellular Components for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7836447
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with FXYD3: view

Pathways & Interactions for FXYD3 Gene

genes like me logo Genes that share pathways with FXYD3: view

Pathways by source for FXYD3 Gene

Gene Ontology (GO) - Biological Process for FXYD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006821 chloride transport TAS 7836447
GO:0034220 ion transmembrane transport TAS --
GO:1902476 chloride transmembrane transport IEA --
genes like me logo Genes that share ontologies with FXYD3: view

No data available for SIGNOR curated interactions for FXYD3 Gene

Drugs & Compounds for FXYD3 Gene

(2) Additional Compounds for FXYD3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
genes like me logo Genes that share compounds with FXYD3: view

Transcripts for FXYD3 Gene

Unigene Clusters for FXYD3 Gene

FXYD domain containing ion transport regulator 3:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: - -
SP2: - -
SP3: -
SP4: - - -
SP5:
SP6: -

Relevant External Links for FXYD3 Gene

GeneLoc Exon Structure for
FXYD3
ECgene alternative splicing isoforms for
FXYD3

Expression for FXYD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FXYD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD3 Gene

This gene is overexpressed in Colon - Transverse (x17.9) and Esophagus - Mucosa (x4.6).

Protein differential expression in normal tissues from HIPED for FXYD3 Gene

This gene is overexpressed in Nasal epithelium (23.5), Colon (15.5), and Rectum (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FXYD3 Gene



Protein tissue co-expression partners for FXYD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FXYD3 Gene:

FXYD3

SOURCE GeneReport for Unigene cluster for FXYD3 Gene:

Hs.301350

mRNA Expression by UniProt/SwissProt for FXYD3 Gene:

Q14802-FXYD3_HUMAN
Tissue specificity: Expressed in a subset of human breast tumors.

Evidence on tissue expression from TISSUES for FXYD3 Gene

  • Intestine(4.3)
  • Nervous system(3.7)
  • Stomach(2.9)
  • Lung(2.7)
  • Skin(2.4)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with FXYD3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FXYD3 Gene

Orthologs for FXYD3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FXYD3 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FXYD3 34 35
  • 83.14 (n)
rat
(Rattus norvegicus)
Mammalia Fxyd3 34
  • 76.63 (n)
mouse
(Mus musculus)
Mammalia Fxyd3 34 16 35
  • 76.25 (n)
cow
(Bos Taurus)
Mammalia FXYD3 35
  • 76 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 40 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 47 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fxyd3 34
  • 58.91 (n)
Species where no ortholog for FXYD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FXYD3 Gene

ENSEMBL:
Gene Tree for FXYD3 (if available)
TreeFam:
Gene Tree for FXYD3 (if available)

Paralogs for FXYD3 Gene

Paralogs for FXYD3 Gene

(6) SIMAP similar genes for FXYD3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FXYD3: view

Variants for FXYD3 Gene

Sequence variations from dbSNP and Humsavar for FXYD3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000010331 -- 35,119,553(+) TAAGA(A/G)AAGTC intron-variant
rs1000019965 -- 35,114,459(+) CCTCT(A/C)CAGAA upstream-variant-2KB
rs1000125248 -- 35,114,117(+) TTGGA(C/T)GCAGC upstream-variant-2KB
rs1000187675 -- 35,115,360(+) GACCC(C/G/T)AATCC upstream-variant-2KB
rs1000253211 -- 35,124,699(+) GAGGG(A/G)AACCC downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FXYD3 Gene

Variant ID Type Subtype PubMed ID
dgv1773n106 CNV tandem duplication 24896259
esv1002416 CNV insertion 20482838
esv1471418 CNV insertion 17803354
esv3302558 CNV tandem duplication 20981092
esv3381956 CNV insertion 20981092
nsv137954 CNV deletion 16902084
nsv138054 CNV insertion 16902084
nsv138264 CNV insertion 16902084
nsv819858 CNV loss 19587683

Variation tolerance for FXYD3 Gene

Residual Variation Intolerance Score: 83.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.33; 53.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FXYD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FXYD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXYD3 Gene

Disorders for FXYD3 Gene

Relevant External Links for FXYD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FXYD3

No disorders were found for FXYD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FXYD3 Gene

Publications for FXYD3 Gene

  1. Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. (PMID: 7836447) Morrison B.W. … Leder P. (J. Biol. Chem. 1995) 2 3 4 22 64
  2. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PMID: 10950925) Sweadner K.J. … Rael E. (Genomics 2000) 2 3 22 64
  3. Expression and significance of FXYD-3 protein in gastric adenocarcinoma. (PMID: 20364041) Zhu Z.L. … Sun X.F. (Dis. Markers 2010) 3 22 64
  4. Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis. (PMID: 19893046) Okudela K. … Kitamura H. (Am. J. Pathol. 2009) 3 22 64
  5. FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues. (PMID: 19571376) Yamamoto H. … Asano S. (Biol. Pharm. Bull. 2009) 3 22 64

Products for FXYD3 Gene

Sources for FXYD3 Gene

Content
Loading form....