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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FXYD2 Gene

protein-coding GIFtS: 56
GCID: GC11M117673

FXYD domain containing ion transport regulator 2

(Previous names: hypomagnesemia 2, renal )
(Previous symbols: ATP1G1, HOMG2)

Explore 11 diseases affiliated with
FXYD2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
FXYD Domain Containing Ion Transport Regulator 2¹ ²		Hypomagnesemia 2, Renal¹
ATP1G1¹ ² ³ ⁵		ATPase, Na+/K+ Transporting, Gamma 1 Polypeptide²
HOMG2¹ ² ⁵		Sodium/Potassium-Transporting ATPase Subunit Gamma²
Sodium Pump Gamma Chain² ³		ATP1C³
Na(+)/K(+) ATPase Subunit Gamma² ³		FXYD Domain-Containing Ion Transport Regulator 2³
MGC12372¹

External Ids:	HGNC: 4026¹	Entrez Gene: 486²	Ensembl: ENSG00000137731⁷	OMIM: 601814⁵	UniProtKB: P54710³

Export aliases for FXYD2 gene to outside databases

Previous GC identifers: GC11M120047 GC11M119202 GC11M117724 GC11M117228 GC11M117196 GC11M113624

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FXYD2:

This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the

sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal

Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been

observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826)

locus.(provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710

Function: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport

function of the sodium ATPase

Gene Wiki entry for FXYD2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FXYD2 gene promoter:
FOXD1 Nkx2-5 E47 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FXYD2 promoter sequence

Search SABiosciences Chromatin IP Primers for FXYD2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXYD2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23

FXYD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD2 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M117673: view genomic region (about GC identifiers)

Start:	117,672,445 bp from pter	End:	117,699,413 bp from pter
Size:	26,969 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710 (See protein sequence)

Recommended Name: Sodium/potassium-transporting ATPase subunit gamma

Size: 66 amino acids; 7283 Da

Subunit: Composed of three subunits: alpha (catalytic), beta and gamma

Subcellular location: Membrane; Single-pass type III membrane protein (Potential)

Sequence caution: Sequence=AAB09425.1; Type=Frameshift; Positions=12; Sequence=CAA60152.1; Type=Erroneous translation;

Note=Wrong choice of frame;

Secondary accessions: Q15332 Q53YC1 Q9GZP3 Q9GZQ7

Alternative splicing: 2 isoforms: P54710-1 P54710-2

Explore the universe of human proteins at neXtProt for FXYD2: NX_P54710

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P54710

FXYD2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001671.2 NP_067614.1

ENSEMBL proteins:

ENSP00000436414 ENSP00000432430 ENSP00000292079 ENSP00000260287

Reactome Protein details: P54710
Human Recombinant Protein Products for FXYD2:

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	Novus Biologicals FXYD2 Protein Novus Biologicals FXYD2 Lysates
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	Uscn Proteins for FXYD2

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005890	sodium:potassium-exchanging ATPase complex	NAS	--
GO:0016323	basolateral plasma membrane	IEA	--
GO:0043231	intracellular membrane-bounded organelle	IEA	--

FXYD2 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for FXYD2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FXYD2 for domains About GeneDecksing

1 InterPro domain/family:

IPR000272 Ion-transport_regulator_FXYD

Graphical View of Domain Structure for InterPro Entry P54710

ProtoNet protein and cluster: P54710

1 Blocks protein family: IPB000272 FXYD protein

UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710

Similarity: Belongs to the FXYD family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: ATNG_HUMAN, P54710

Function: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport

function of the sodium ATPase

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005215	transporter activity	TAS	9048881
GO:0005216	ion channel activity	NAS	--
GO:0005391	sodium:potassium-exchanging ATPase activity	IEA	--

FXYD2 for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for FXYD2:

Decreased Hepatitis C virus re

Increased G1 DNA content

Increased gamma-H2AX phosphory

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Fxyd2):

normal

FXYD2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Fxyd2^tm1Kdr for FXYD2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FXYD2

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FXYD2 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FXYD2 (see all 7) OriGene shRNA RFP: FXYD2 OriGene siRNA: FXYD2
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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FXYD2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/14 super-pathways (see all 14) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ion channel transport

Ion channel transport

1.00

Ion transport by P-type ATPases

0.32

Diuretics Pathway, Pharmacodynamics

Diuretics Pathway, Pharmacodynamics

1.00

Mineral absorption

Mineral absorption

1.00

Bile secretion

Bile secretion

1.00

Protein digestion and absorption

Protein digestion and absorption

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for FXYD2

Calcium Regulation in the Cardiac Cell

3 Reactome Pathways for FXYD2

	Transmembrane transport of small molecules
	Ion channel transport
	Ion transport by P-type ATPases

1 PharmGKB Pathway for FXYD2

Diuretics Pathway, Pharmacodynamics

5/10 Kegg Pathways (Kegg details for FXYD2) (see all 10):

	Cardiac muscle contraction
	Aldosterone-regulated sodium reabsorption
	Endocrine and other factor-regulated calcium reabsorption
	Proximal tubule bicarbonate reclamation
	Salivary secretion

FXYD2 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for FXYD2

1 Interacting protein for FXYD2 (P54710³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATP1A1	P05023³	I2D: score=1

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001558	regulation of cell growth	IEA	--
GO:0006810	transport	TAS	9048881
GO:0006811	ion transport	NAS	--
GO:0034220	ion transmembrane transport	TAS	--
GO:0042127	regulation of cell proliferation	IEA	--

FXYD2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FXYD2 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FXYD2

3 HMDB Compounds for FXYD2 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Magnesium	Magnesium (see all 2)	7439-95-4	--
Sodium	Sodium (see all 2)	7440-23-5	--

1 DrugBank Compound for FXYD2 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Cyclothiazide	Ciclotiazida [INN-Spanish] (see all 3)	2259-96-3	target	inhibitor	17139284 17016423

1 Novoseek chemical compound relationship for FXYD2 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
magnesium	44.2	1	19780717 (1)

Search CenterWatch for drugs/clinical trials and news about FXYD2 / ATNG

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FXYD2 gene (3 alternative transcripts):

NM_001680.4 NM_021603.3 NM_001127489.1

Unigene Cluster for FXYD2:

FXYD domain containing ion transport regulator 2

Hs.731865 [show with all ESTs]

Unigene Representative Sequence: BX641053

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000532119 ENST00000528014(uc001prk.1) ENST00000292079(uc001prj.2)

ENST00000260287 ENST00000534383 ENST00000533281 ENST00000317594(uc001prl.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): FXYD2 Browse OriGene MicroRNA Expression Plasmids
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		Sirion Biotech Custom design and validation of potent shRNA sequences against FXYD2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD2 (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXYD2 (see all 4) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXYD2

Additional cDNA sequence:

AF241236.1 AK096069.1 AK296195.1 BC005302.1 BC013289.1 BT006721.1 BX641053.1 DQ786191.1

U50743.1

9 DOTS entries:

DT.100746918 DT.441277 DT.91744793 DT.86847137 DT.92018615 DT.120713711 DT.95280076 DT.100009363

DT.91696981

24/86 AceView cDNA sequences (see all 86):

AF241236 NM_001680 AK096069 AL697779 AL831840 BX095407 BX090833 BX282324

BI838610 BG163290 BG249824 NM_021603 BI764844 AA309757 BG164027 BE504423

AA776478 AA366695 BT006721 BX641053 BM263111 AW303292 BI761619 BC013289

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FXYD2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTATAATAA

About this image

FXYD2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Early limb mesenchymal cells (ELM cells) (Primary Cell)

Bone, Cartilage, Limb

PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)

Intermediate Mesoderm, Kidney

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FXYD2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FXYD2

SOURCE GeneReport for Unigene cluster: Hs.731865

UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710

Tissue specificity: Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron

epithelial cells

SABiosciences Custom PCR Arrays for FXYD2

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXYD2

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FXYD2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for FXYD2 gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Fxyd2^{1 , 5}	FXYD domain-containing ion transport regulator 2^{1, 5}	82.54(n)¹ 80.95(a)¹		9 (24.84 cM)⁵ 11936¹ NM_052823.2¹ NP_439888.1¹ 45403138⁵

ENSEMBL Gene Tree for FXYD2 (if available)
TreeFam Gene Tree for FXYD2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs28938168^1,2	C	pathogenic	119747045(-)	`TCGTGA/GGGCTC`	4	R G	mis¹		0	--	--	--	--
rs78234838^1,2	F	--	113624378(+)	`GCAGGG/TTCGCT`	2	--	ds500¹		1		WA	118
rs78703162^1,2	F	--	113624443(+)	`CTGTGG/ATTTTG`	2	--	ds500¹		1		NA	120
rs41304349^1,2	C,F	--	113624711(+)	`TCTGAC/TGNNNN`	2	--	ut3¹		1		NA	120
rs78017409^1,2	C	--	113624821(+)	`ACGGGG/AACAAA`	2	--	ut3¹		2		WA	120
rs869790^1,2	C,F,A,H	--	113625888(-)	`gctcaT/Cgcctg`	2	--	int¹		6		MN NA WA	314
rs11827753^1,2	H	--	113626016(+)	`ATATCG/AAGAGT`	2	--	int¹		4		NS EA	416
rs12365759^1,2	C,H	--	113626060(+)	`GCACAG/ACTGCC`	2	--	int¹		4		NS EA	414
rs11828216^1,2	C,F,H	--	113626159(+)	`CCACCC/TGGCAC`	2	--	int¹		16		NS EA WA NA	1914
rs12280668^1,2	C,F,H	--	113626495(+)	`AGGATA/GCATAA`	2	--	int¹		12		NS EA NA WA	1314

HapMap Linkage Disequilibrium report for FXYD2 (117672445 - 117699413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FXYD2
1 CNV: 48705
Human Gene Mutation Database (HGMD): FXYD2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FXYD2

DNA2.0 Custom Variant and Variant Library Synthesis for FXYD2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FXYD2 for disorders           About GeneDecksing

OMIM gene information: 601814
OMIM disorders: 154020
UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710

Defects in FXYD2 are the cause of hypomagnesemia type 2 (HOMG2) [MIM:154020]; also known as dominant renal

hypomagnesemia or hypomagnesemia with hypocalciuria. HOMG2 is a disorder due to primary renal wasting of magnesium.

Plasma levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is

lowered renal excretion of calcium resulting in hypocalciuria

11 diseases for FXYD2: About MalaCards

hypomagnesemia hypomagnesemia 2, renal glycogen storage disease type 1b glycogen storage disease

renal tubular acidosis bartter disease pseudohypoaldosteronism nephrocalcinosis

aldosteronism choroiditis pancreatitis

1 disease from the University of Copenhagen DISEASES database for FXYD2:

Nephrocalcinosis

1 Novoseek disease relationship for FXYD2 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hypomagnesemia	85.4	7	17980699 (2), 19865785 (2), 12584272 (1), 11062458 (1) (see all 5)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for FXYD2 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with FXYD2)

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Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma- subunit. (PubMed id 9048881)^{1, 2, 3} Kim J.W.... Choe I.S. (1997)
Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase. (PubMed id 11112438)^{1, 2, 9} Sweadner K.J.... Arystarkhova E. (2000)
Dominant isolated renal magnesium loss is caused by misrouting of the Na+,K+-ATPase gamma-subunit. (PubMed id 11062458)^{1, 2, 9} Meij I.C.... Knoers N.V.A.M. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Hereditary isolated renal magnesium loss maps to chro mosome 11q23. (PubMed id 9915957)^{1, 3} Meij I.C....Knoers N.V. (1999)
FXYD2 and Na,K-ATPase expression in isolated human pr oximal tubular cells: disturbed upregulation on renal hypomagnesemia? (PubMed id 19865785)^{1, 9} Cairo E.R....Koenderink J.B. (2009)
A genomic-based approach identifies FXYD domain conta ining ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specifi c biomarker. (PubMed id 20379810)^{1, 9} Flamez D....Eizirik D.L. (2010)
Identification of a crab gill FXYD2 protein and regula tion of crab microsomal Na,K-ATPase activity by mammalian FXYD2 peptide. (PubMed id 22588134)¹ Silva E.C....Fontes C.F. (2012)
HNF-1B specifically regulates the transcription of th e I^a-subunit of the Na+/K+-ATPase. (PubMed id 21130072)¹ FerrA" S....Bindels R.J. (2011)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 486	HGNC: 4026	AceView: FXYD2	Ensembl:ENSG00000137731	euGenes: HUgn486
ECgene: FXYD2	Kegg: 486	H-InvDB: FXYD2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for FXYD2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for FXYD2 gene
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FXYD domain containing ion transport regulator 2

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FXYD domain containing ion transport regulator 2

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