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FXYD2 Gene

protein-coding   GIFtS: 53
GCID: GC11M117673

FXYD Domain Containing Ion Transport Regulator 2

(Previous names: hypomagnesemia 2, renal)
(Previous symbols: ATP1G1, HOMG2)
  See FXYD2-related disease
at
MalaCards
 

Aliases
for FXYD2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FXYD Domain Containing Ion Transport Regulator 21 2     Hypomagnesemia 2, Renal1
ATP1G11 2 3 5     ATPase, Na+/K+ Transporting, Gamma 1 Polypeptide2
HOMG21 2 5     Sodium/Potassium-Transporting ATPase Subunit Gamma2
Sodium Pump Gamma Chain2 3     ATP1C3
Na(+)/K(+) ATPase Subunit Gamma2 3     FXYD Domain-Containing Ion Transport Regulator 23

External Ids:    HGNC: 40261   Entrez Gene: 4862   Ensembl: ENSG000001377317   OMIM: 6018145   UniProtKB: P547103   

Export aliases for FXYD2 gene to outside databases

Previous GC identifers: GC11M120047 GC11M119202 GC11M117724 GC11M117228 GC11M117196 GC11M113624


Summaries
for FXYD2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FXYD2 Gene:
This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the
sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal
Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have
been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID
53826) locus.(provided by RefSeq, Feb 2011)

GeneCards Summary for FXYD2 Gene:
FXYD2 (FXYD domain containing ion transport regulator 2) is a protein-coding gene. Diseases associated with FXYD2 include hypomagnesemia 2, renal. GO annotations related to this gene include sodium:potassium-exchanging ATPase activity and transporter activity.

UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710
Function: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport
function of the sodium ATPase

Gene Wiki entry for FXYD2 Gene


Genomic Views
for FXYD2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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TryGeneCards Plus		 Regulatory elements:
   Regulatory transcription factor binding sites in the FXYD2 gene promoter:
         FOXD1   Nkx2-5   E47   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FXYD2 promoter sequence
   Search Chromatin IP Primers for FXYD2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FXYD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q23   Ensembl cytogenetic band:  11q23.3   HGNC cytogenetic band: 11q23

FXYD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M117673:  view genomic region     (about GC identifiers)

Start:
 117,671,559 bp from pter      End:
 117,699,413 bp from pter
Size:
 27,855 bases      Orientation:
 minus strand

Proteins
for FXYD2 gene

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710 (See protein sequence)
Recommended Name: Sodium/potassium-transporting ATPase subunit gamma  
Size: 66 amino acids; 7283 Da
Subunit: Composed of three subunits: alpha (catalytic), beta and gamma
Sequence caution: Sequence=AAB09425.1; Type=Frameshift; Positions=12; Sequence=CAA60152.1; Type=Erroneous
translation; Note=Wrong choice of frame;
Secondary accessions: Q15332 Q53YC1 Q9GZP3 Q9GZQ7
Alternative splicing: 2 isoforms:  P54710-1   P54710-2   

Explore the universe of human proteins at neXtProt for FXYD2: NX_P54710

Explore proteomics data for FXYD2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

    • See FXYD2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001671.2  NP_067614.1  

    ENSEMBL proteins: 
     ENSP00000436414   ENSP00000432430   ENSP00000292079   ENSP00000260287  
    Reactome Protein details: P54710

    FXYD2 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

         		 Search eBioscience for Proteins for FXYD2 

         		antibodies-online proteins for FXYD2 (2 products) 

         		 Search antibodies-online for peptides for FXYD2

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    antibodies-online antibodies for FXYD2 (14 products) 

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    antibodies-online kits for FXYD2 (9 products) 

    Domains /
    Families
    for FXYD2 gene

    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus    		 1 InterPro protein domain:
     IPR000272 Ion-transport_regulator_FXYD

    Graphical View of Domain Structure for InterPro Entry P54710

    ProtoNet protein and cluster: P54710

    1 Blocks protein domain: IPB000272 FXYD protein

    UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710
    Similarity: Belongs to the FXYD family


    Find genes that share domains with FXYD2           About GenesLikeMe


    Function
    for FXYD2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ATNG_HUMAN, P54710
    Function: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport
    function of the sodium ATPase

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005215transporter activity TAS9048881
    GO:0005216ion channel activity IEA--
    GO:0005391sodium:potassium-exchanging ATPase activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FXYD2           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for FXYD2:
     Decreased Hepatitis C virus re  Increased G1 DNA content  Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Fxyd2):
     normal 

    Find genes that share phenotypes with FXYD2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fxyd2tm1Kdr for FXYD2

       genOway: Develop your customized and physiologically relevant rodent model for FXYD2

    miRNA
    Products:            		miRTarBase miRNAs that target FXYD2:
    hsa-mir-128-3p (MIRT022024), hsa-mir-148b-3p (MIRT019415)

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    Inhib. RNA
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    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): FXYD2 (NM_021603)
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    Addgene plasmids for FXYD2 

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    In Situ Assay
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    Localization
    for FXYD2 gene

    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

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    Subcellular locations from UniProtKB/Swiss-Prot
    ATNG_HUMAN, P54710: Membrane; Single-pass type III membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1
    extracellular1
    golgi apparatus1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005890sodium:potassium-exchanging ATPase complex IEA--
    GO:0016020membrane ----
    GO:0016323basolateral plasma membrane IEA--
    GO:0043231intracellular membrane-bounded organelle IEA--

    Find genes that share ontologies with FXYD2           About GenesLikeMe


    Pathways & Interactions
    for FXYD2 gene

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FXYD2 About   (see all 18)  
    See pathways by source

    		      Powered
    by    		     
    SuperPathContained pathways About
    1Insulin secretion
    		Insulin secretion0.36
    		Thyroid hormone synthesis0.36
    2Ion channel transport
    		Ion channel transport0.58
    3Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    		Transmembrane transport of small molecules0.47
    4Myometrial Relaxation and Contraction Pathways
    		Calcium Regulation in the Cardiac Cell0.43
    5Salivary secretion
    		Salivary secretion0.34


    Find genes that share SuperPaths with FXYD2           About GenesLikeMe

    Pathways by source                                   See SuperPaths
    Show all pathways


    1 BioSystems Pathway for FXYD2
        Calcium Regulation in the Cardiac Cell


    1 Reactome Pathway for FXYD2
        Ion transport by P-type ATPases

    1 PharmGKB Pathway for FXYD2
        Diuretics Pathway, Pharmacodynamics

    Selected Kegg Pathways  (Kegg details for FXYD2) (see all 14):
        Cardiac muscle contraction
    Adrenergic signaling in cardiomyocytes
    Insulin secretion
    Thyroid hormone synthesis
    Thyroid hormone signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FXYD2
    Interactions:

        Search GeneGlobe Interaction Network for FXYD2

    1 Interacting protein for FXYD2 (P547103) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ATP1A1P050233I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001558regulation of cell growth IEA--
    GO:0006810transport TAS9048881
    GO:0006811ion transport ----
    GO:0006813potassium ion transport ----
    GO:0006814sodium ion transport ----

    Find genes that share ontologies with FXYD2           About GenesLikeMe



    Drugs & Compounds
    for FXYD2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FXYD2 (ATNG)

    3 HMDB Compounds for FXYD2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--
    SodiumSodium (see all 2)7440-23-5--

    1 DrugBank Compound for FXYD2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    CyclothiazideCiclotiazida [INN-Spanish] (see all 3)2259-96-3targetinhibitor17139284 17016423

    1 Novoseek inferred chemical compound relationship for FXYD2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    magnesium 44.2 1 19780717 (1)



    Find genes that share compounds with FXYD2           About GenesLikeMe



    Transcripts
    for FXYD2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FXYD2 gene (3 alternative transcripts): 
    NM_001680.4  NM_021603.3  NM_001127489.1  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000514385 ENST00000532119 ENST00000528014(uc001prk.1) ENST00000292079(uc001prj.2)
    ENST00000260287 ENST00000534383 ENST00000533281 ENST00000317594(uc001prl.3)

    miRNA
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    Inhib. RNA
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    Addgene plasmids for FXYD2 
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    OriGene qSTAR qPCR primer pairs in human, mouse for FXYD2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat FXYD2
      QuantiTect SYBR Green Assays in human, mouse, rat FXYD2
      QuantiFast Probe-based Assays in human, mouse, rat FXYD2

    Selected AceView cDNA sequences (see all 86):

    BX095407 BX282324 AK096069 AF241236 AL697779 NM_001680 BX090833 AL831840 
    BI838610 AI033312 AW303292 BC005302 BX641053 NM_021603 BX101988 BG168993 
    BE738880 BE504423 BM263111 AW117369 BM142682 AA309757 BC013289 BG164027 

    GeneLoc Exon Structure


    Expression
    for FXYD2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    FXYD2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTATAATAA
    FXYD2 Expression
    About this image


    FXYD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Adipose (Muscoskeletal System)
             Visceral White Adipose
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Pancreas (Endocrine System)
    FXYD2 Protein expression data from MOPED1, PaxDb2 and MaxQB3:     About this image

    FXYD2 Protein Expression

    UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710
    Tissue specificity: Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of
    nephron epithelial cells

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    In Situ
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    Orthologs
    for FXYD2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of human and mouse.

    Orthologs for FXYD2 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fxyd25 FXYD domain-containing ion transport regulator 2   --   9 (24.84 cM) 45403138 


    ENSEMBL Gene Tree for FXYD2 (if available)
    TreeFam Gene Tree for FXYD2 (if available)

    Paralogs
    for FXYD2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FXYD2 gene
    5 SIMAP similar genes for FXYD2 using alignment to 3 protein entries:     ATNG_HUMAN (see all proteins):
    FXYD6    FXYD7    FXYD1    FXYD3    FXYD6P3

    Find genes that share paralogs with FXYD2           About GenesLikeMe



    Genomic Variants
    for FXYD2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for FXYD2 (see all 308)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs289381681,2,,4
    		CHypomagnesemia 2 (HOMG2)4 pathogenic1117556740(-) TCGTGA/GGGCTC 4 R G mis10--------
    rs20772751,2
    		C--113634461(-) AAAAAG/AGGGCT 1 -- us2k1 trp32Minor allele frequency- A:0.25NA WA 4
    rs1419349201,2
    		--117553922(+) AATAGA/GTGGCC 2 -- ds50010--------
    rs1890184731,2
    		--117553957(+) AGCTTA/GGTACC 2 -- ds50010--------
    rs1164587021,2
    		F--117553958(+) GCTTAG/TTACCA 2 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1158640411,2
    		F--117553962(+) AGTACC/TAGGAG 2 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1817345261,2
    		--117553991(+) GGCTCC/TTTCAG 2 -- ds50010--------
    rs116002161,2
    		C,F,H--117554001(+) GGACAT/CGTGCA 2 -- ds500119Minor allele frequency- C:0.15NS EA NA 2358
    rs116002261,2
    		C,F,A,H--117554024(+) CAGGCT/CCCCCG 2 -- ds500118Minor allele frequency- C:0.19NS EA NA CSA WA 2298
    rs5888071,2
    		C,F,O,H--117554097(+) ACACAC/GAGGCC 2 -- ds500121Minor allele frequency- G:0.03MN NA NS EA WA CSA 1005

    HapMap Linkage Disequilibrium report for FXYD2 (117671559 - 117699413 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FXYD2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv526267CNV Loss19592680
    dgv1317n71CNV Loss21882294
    nsv517470CNV Loss19592680

    Human Gene Mutation Database (HGMD): FXYD2
    Site Specific Mutation Identification with PCR Assays
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    Disorders / Diseases
    for FXYD2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TryGeneCards Plus    		 OMIM gene information: 601814   
    OMIM disorders: 154020  
    UniProtKB/Swiss-Prot: ATNG_HUMAN, P54710
  • Hypomagnesemia 2 (HOMG2) [MIM:154020]: A disorder due to primary renal wasting of magnesium. Plasma
    levels of other electrolytes are normal. The only abnormality found, in addition to low magnesium levels, is
    lowered renal excretion of calcium resulting in hypocalciuria. Note=The disease is caused by mutations affecting
    the gene represented in this entry

    • 1 disease for FXYD2:    
    About MalaCards
    hypomagnesemia 2, renal

    1 inferred disease relationship from the University of Copenhagen DISEASES database for FXYD2:
    Nephrocalcinosis

    Find genes that share disorders with FXYD2           About GenesLikeMe

    1 Novoseek inferred disease relationship for FXYD2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypomagnesemia 85.4 7 17980699 (2), 19865785 (2), 12584272 (1), 11062458 (1) (see all 5)


    Export disorders for FXYD2 gene to outside databases

    Publications
    for FXYD2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FXYD2 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with FXYD2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of human cDNA encoding Na+, K(+)-ATPase gamma- subunit. (PubMed id 9048881)1, 2, 3 Kim J.W.... Choe I.S. (Biochim. Biophys. Acta 1997)
    2. Genomic organization of the human FXYD2 gene encoding the gamma subunit of the Na,K-ATPase. (PubMed id 11112438)1, 2, 9 Sweadner K.J.... Arystarkhova E. (Biochem. Biophys. Res. Commun. 2000)
    3. Dominant isolated renal magnesium loss is caused by misrouting of the Na+,K+-ATPase gamma-subunit. (PubMed id 11062458)1, 2, 9 Meij I.C.... Knoers N.V.A.M. (Nat. Genet. 2000)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Hereditary isolated renal magnesium loss maps to chromosome 11q23. (PubMed id 9915957)1, 3 Meij I.C....Knoers N.V. (Am. J. Hum. Genet. 1999)
    6. FXYD2 and Na,K-ATPase expression in isolated human proximal tubular cells: disturbed upregulation on renal hypomagnesemia? (PubMed id 19865785)1, 9 Cairo E.R....Koenderink J.B. (J. Membr. Biol. 2009)
    7. A genomic-based approach identifies FXYD domain containing ion transport regulator 2 (FXYD2)gammaa as a pancreatic beta cell-specific biomarker. (PubMed id 20379810)1, 9 Flamez D....Eizirik D.L. (Diabetologia 2010)
    8. Expression of the Na+/K+-transporting ATPase gamma subunit FXYD2 in renal tumors. (PubMed id 23196795)1 Gaut J.P....Ladenson J.H. (Mod. Pathol. 2013)
    9. Identification of a crab gill FXYD2 protein and regulation of crab microsomal Na,K-ATPase activity by mammalian FXYD2 peptide. (PubMed id 22588134)1 Silva E.C....Fontes C.F. (Biochim. Biophys. Acta 2012)
    10. HNF-1B specifically regulates the transcription of the I^a-subunit of the Na+/K+-ATPase. (PubMed id 21130072)1 FerrA" S....Bindels R.J. (Biochem. Biophys. Res. Commun. 2011)

    External Searches for FXYD2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing FXYD2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 486 HGNC: 4026 AceView: FXYD2 Ensembl:ENSG00000137731 euGenes: HUgn486
    ECgene: FXYD2 Kegg: 486 H-InvDB: FXYD2

    Other Databases showing FXYD2 gene

    (According to HUGE)
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    Specialized Databases showing FXYD2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FXYD2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for FXYD2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus    		Patent Information for FXYD2 gene:
    Search GeneIP for patents involving FXYD2

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