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Aliases for FXYD1 Gene

Aliases for FXYD1 Gene

  • FXYD Domain Containing Ion Transport Regulator 1 2 3 5
  • PLM 3 4
  • FXYD Domain-Containing Ion Transport Regulator 1 4
  • Phospholemman 2

External Ids for FXYD1 Gene

Previous HGNC Symbols for FXYD1 Gene

  • PLM

Previous GeneCards Identifiers for FXYD1 Gene

  • GC19P036247
  • GC19P036078
  • GC19P040305
  • GC19P040322
  • GC19P040323
  • GC19P040324
  • GC19P035629
  • GC19P032137
  • GC19P035139

Summaries for FXYD1 Gene

Entrez Gene Summary for FXYD1 Gene

  • This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature. [provided by RefSeq, Jul 2008]

GeneCards Summary for FXYD1 Gene

FXYD1 (FXYD Domain Containing Ion Transport Regulator 1) is a Protein Coding gene. Diseases associated with FXYD1 include Periodic Limb Movement Disorder and Rett Syndrome. Among its related pathways are cAMP signaling pathway and Ion channel transport. GO annotations related to this gene include ion channel activity and chloride channel activity. An important paralog of this gene is FXYD6-FXYD2.

UniProtKB/Swiss-Prot for FXYD1 Gene

  • May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.

Gene Wiki entry for FXYD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXYD1 Gene

Genomics for FXYD1 Gene

Regulatory Elements for FXYD1 Gene

Enhancers for FXYD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FXYD1 on UCSC Golden Path with GeneCards custom track

Promoters for FXYD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FXYD1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FXYD1 gene promoter:

Genomic Location for FXYD1 Gene

35,138,789 bp from pter
35,143,109 bp from pter
4,321 bases
Plus strand

Genomic View for FXYD1 Gene

Genes around FXYD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXYD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXYD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXYD1 Gene

Proteins for FXYD1 Gene

  • Protein details for FXYD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • A8K196

    Protein attributes for FXYD1 Gene

    92 amino acids
    Molecular mass:
    10441 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FXYD1 Gene

neXtProt entry for FXYD1 Gene

Proteomics data for FXYD1 Gene at MOPED

Post-translational modifications for FXYD1 Gene

  • Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be phosphorylated by DMPK.
  • Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FXYD1 Gene

Domains & Families for FXYD1 Gene

Protein Domains for FXYD1 Gene


Suggested Antigen Peptide Sequences for FXYD1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FXYD family.
  • Belongs to the FXYD family.
genes like me logo Genes that share domains with FXYD1: view

No data available for Gene Families for FXYD1 Gene

Function for FXYD1 Gene

Molecular function for FXYD1 Gene

UniProtKB/Swiss-Prot Function:
May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current when exogenously expressed.
genes like me logo Genes that share phenotypes with FXYD1: view

Animal Models for FXYD1 Gene

MGI Knock Outs for FXYD1:

Animal Model Products

  • Taconic Biosciences Mouse Models for FXYD1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FXYD1 Gene

Localization for FXYD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXYD1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for FXYD1 Gene COMPARTMENTS Subcellular localization image for FXYD1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1
extracellular 1

Gene Ontology (GO) - Cellular Components for FXYD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0034707 chloride channel complex IEA --
genes like me logo Genes that share ontologies with FXYD1: view

Pathways & Interactions for FXYD1 Gene

genes like me logo Genes that share pathways with FXYD1: view

Pathways by source for FXYD1 Gene

SIGNOR curated interactions for FXYD1 Gene

Other effect:

Gene Ontology (GO) - Biological Process for FXYD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008016 regulation of heart contraction TAS 19683723
GO:0034220 ion transmembrane transport TAS --
GO:0055085 transmembrane transport TAS --
GO:1902476 chloride transmembrane transport TAS 9169143
GO:1903278 positive regulation of sodium ion export from cell IEA,ISS --
genes like me logo Genes that share ontologies with FXYD1: view

Drugs & Compounds for FXYD1 Gene

(1) Drugs for FXYD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cyclic amp Experimental Pharma 0

(1) Additional Compounds for FXYD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
genes like me logo Genes that share compounds with FXYD1: view

Transcripts for FXYD1 Gene

Unigene Clusters for FXYD1 Gene

FXYD domain containing ion transport regulator 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FXYD1 Gene

No ASD Table

Relevant External Links for FXYD1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FXYD1 Gene

mRNA expression in normal human tissues for FXYD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FXYD1 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for FXYD1 Gene

This gene is overexpressed in Adrenal (45.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FXYD1 Gene

SOURCE GeneReport for Unigene cluster for FXYD1 Gene Hs.442498

mRNA Expression by UniProt/SwissProt for FXYD1 Gene

Tissue specificity: Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis.
genes like me logo Genes that share expression patterns with FXYD1: view

Protein tissue co-expression partners for FXYD1 Gene

Primer Products

Orthologs for FXYD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FXYD1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FXYD1 35
  • 89.13 (n)
  • 90.22 (a)
FXYD1 36
  • 90 (a)
(Canis familiaris)
Mammalia FXYD1 35
  • 91.67 (n)
  • 90.22 (a)
FXYD1 36
  • 90 (a)
(Mus musculus)
Mammalia Fxyd1 35
  • 84.42 (n)
  • 82.61 (a)
Fxyd1 16
Fxyd1 36
  • 83 (a)
(Pan troglodytes)
Mammalia FXYD1 35
  • 99.64 (n)
  • 100 (a)
FXYD1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Fxyd1 35
  • 86.23 (n)
  • 83.7 (a)
(Monodelphis domestica)
Mammalia FXYD1 36
  • 30 (a)
(Anolis carolinensis)
Reptilia FXYD1 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fxyd1 35
  • 64.71 (n)
  • 70.59 (a)
Str.13949 35
(Danio rerio)
Actinopterygii fxyd6l 36
  • 35 (a)
Species with no ortholog for FXYD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FXYD1 Gene

Gene Tree for FXYD1 (if available)
Gene Tree for FXYD1 (if available)

Paralogs for FXYD1 Gene

Paralogs for FXYD1 Gene

(5) SIMAP similar genes for FXYD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FXYD1: view

Variants for FXYD1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FXYD1 Gene

Variant ID Type Subtype PubMed ID
dgv3849n71 CNV Loss 21882294
nsv911617 CNV Loss 21882294
esv2718490 CNV Deletion 23290073

Variation tolerance for FXYD1 Gene

Residual Variation Intolerance Score: 61.7% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for FXYD1 Gene

Disorders for FXYD1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FXYD1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
periodic limb movement disorder
  • nocturnal myoclonus
rett syndrome
  • rett syndrome, preserved speech variant
sleep disorder
  • non-organic sleep disorder
- elite association - COSMIC cancer census association via MalaCards
Search FXYD1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FXYD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FXYD1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FXYD1 Gene

Publications for FXYD1 Gene

  1. Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1. (PMID: 9169143) Chen L.-S.K. … Cuddy M. (Genomics 1997) 2 3 4 67
  2. Expression and distribution of Na, K-ATPase isoforms in the human uterus. (PMID: 20065300) Floyd R.V. … Mobasheri A. (Reprod. Sci. 2010) 3 23
  3. Molecular Mechanisms and Kinetic Effects of FXYD1 and Phosphomimetic Mutants on Purified Human Na,K-ATPase. (PMID: 26429909) Mishra N.K. … Karlish S.J. (J. Biol. Chem. 2015) 3
  4. G-quadruplex formation of FXYD1 pre-mRNA indicates the possibility of regulating expression of its protein product. (PMID: 25051342) Dhayan H. … Kukol A. (Arch. Biochem. Biophys. 2014) 3
  5. Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1). (PMID: 23224879) Cheung J.Y. … Wang J. (Adv. Exp. Med. Biol. 2013) 3

Products for FXYD1 Gene

Sources for FXYD1 Gene