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FXYD1 Gene

protein-coding   GIFtS: 53
GCID: GC19P035629

FXYD Domain Containing Ion Transport Regulator 1

(Previous name: phospholemman)
(Previous symbol: PLM)
  See FXYD1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
FXYD Domain Containing Ion Transport Regulator 11 2
PLM1 2 3 5
phospholemman1 2
FXYD Domain-Containing Ion Transport Regulator 13

External Ids:    HGNC: 40251   Entrez Gene: 53482   Ensembl: ENSG000002669647   OMIM: 6023595   UniProtKB: O001683   

Export aliases for FXYD1 gene to outside databases

Previous GC identifers: GC19P036247 GC19P036078 GC19P040305 GC19P040322 GC19P040323 GC19P040324 GC19P032137


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FXYD1 Gene:
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence
domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The
approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5
has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase,
regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and
FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology
has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the
C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane
substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy
kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different
5' UTR sequences have been described in the literature. (provided by RefSeq, Jul 2008)

GeneCards Summary for FXYD1 Gene:
FXYD1 (FXYD domain containing ion transport regulator 1) is a protein-coding gene. Diseases associated with FXYD1 include spinal cord injury. GO annotations related to this gene include chloride channel activity. An important paralog of this gene is FXYD6.

UniProtKB/Swiss-Prot: PLM_HUMAN, O00168
Function: May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current
when exogenously expressed

Gene Wiki entry for FXYD1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FXYD1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFXYD1 promoter sequence
   Search Chromatin IP Primers for FXYD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FXYD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.1

FXYD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXYD1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P035629:  view genomic region     (about GC identifiers)

Start:
35,629,712 bp from pter      End:
35,634,013 bp from pter
Size:
4,302 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PLM_HUMAN, O00168 (See protein sequence)
Recommended Name: Phospholemman precursor  
Size: 92 amino acids; 10441 Da
2 PDB 3D structures from and Proteopedia for FXYD1:
2J1I (3D)        2JO1 (3D)    
Secondary accessions: A8K196

Explore the universe of human proteins at neXtProt for FXYD1: NX_O00168

Explore proteomics data for FXYD1 at MOPED

Post-translational modifications: 

  • Major plasma membrane substrate for cAMP-dependent protein kinase (PK-A) and protein kinase C (PK-C) in several
    different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation. May be
    phosphorylated by DMPK1
  • Palmitoylation increases half-life and stability, it is enhanced upon phosphorylation at Ser-88 by PKA1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See FXYD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001265646.1  NP_001265647.1  NP_005022.2  NP_068702.1  

    ENSEMBL proteins: 
     ENSP00000343314   ENSP00000466398   ENSP00000393611   ENSP00000465289   ENSP00000468535  
     ENSP00000467727   ENSP00000467818  
    Reactome Protein details: O00168

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000272 Ion-transport_regulator_FXYD

    Graphical View of Domain Structure for InterPro Entry O00168

    ProtoNet protein and cluster: O00168

    1 Blocks protein domain: IPB000272 FXYD protein

    UniProtKB/Swiss-Prot: PLM_HUMAN, O00168
    Similarity: Belongs to the FXYD family


    Find genes that share domains with FXYD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PLM_HUMAN, O00168
    Function: May have a functional role in muscle contraction. Induces a hyperpolarization-activated chloride current
    when exogenously expressed

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005216ion channel activity ----
    GO:0005254chloride channel activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FXYD1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for FXYD1:
     Increased cell number in S and 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fxyd1):
     cardiovascular system  muscle 

    Find genes that share phenotypes with FXYD1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fxyd1tm1Atck for FXYD1

       genOway: Develop your customized and physiologically relevant rodent model for FXYD1

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    hsa-miR-764
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PLM_HUMAN, O00168: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    extracellular2
    lysosome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS9169143
    GO:0016020membrane ----
    GO:0034707chloride channel complex IEA--

    Find genes that share ontologies with FXYD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FXYD1 About    
    See pathways by source

    SuperPathContained pathways About
    1Ion channel transport
    Ion channel transport0.58
    2Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
    Transmembrane transport of small molecules0.47
    3Ion transport by P-type ATPases
    Ion transport by P-type ATPases


    Find genes that share SuperPaths with FXYD1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for FXYD1
        Ion transport by P-type ATPases


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FXYD1
    Interactions:

        GeneGlobe Interaction Network for FXYD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for FXYD1 (O001683 ENSP000003433144) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPAP2AO144943, ENSP000002647754I2D: score=2 STRING: ENSP00000264775
    PRKACAP176123, ENSP000003095914I2D: score=2 STRING: ENSP00000309591
    PAMP190213, ENSP000003061004I2D: score=1 STRING: ENSP00000306100
    PPP1CAP621363, ENSP000003260314I2D: score=1 STRING: ENSP00000326031
    DMPKQ090133, ENSP000003459974I2D: score=2 STRING: ENSP00000345997
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006811ion transport ----
    GO:0006821chloride transport TAS9169143
    GO:0006874cellular calcium ion homeostasis IEA--
    GO:0006936muscle contraction IEA--
    GO:0034220ion transmembrane transport TAS--

    Find genes that share ontologies with FXYD1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for FXYD1 (PLM)

    2 HMDB Compounds for FXYD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ChlorineCl2 (see all 13)16887-00-6--
    Cyclic AMPCyclic AMP (see all 19)60-92-4--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FXYD1 gene (4 alternative transcripts): 
    NM_001278717.1  NM_001278718.1  NM_005031.4  NM_021902.3  

    Unigene Cluster for FXYD1:

    FXYD domain containing ion transport regulator 1
    Hs.442498  [show with all ESTs]
    Unigene Representative Sequence: AK124802
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000351325(uc002nyc.3) ENST00000592818 ENST00000589209 ENST00000455515(uc002nyd.3)
    ENST00000588715 ENST00000588607 ENST00000587056 ENST00000588081 ENST00000589121
    ENST00000590462
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat FXYD1
      QuantiFast Probe-based Assays in human, mouse, rat FXYD1

    Additional mRNA sequence: 

    AK124802.1 AK289811.1 BC032800.2 GQ258667.1 U72245.1 

    12 DOTS entries:

    DT.447153  DT.40310560  DT.121466335  DT.100769730  DT.100806544  DT.40132477  DT.75101773  DT.75102151 
    DT.95162756  DT.95281757  DT.95325929  DT.97815737 

    Selected AceView cDNA sequences (see all 111):

    T84313 BM856555 BC018619 BM695523 BM663606 CD171939 CR596488 AI199648 
    CR598444 BQ638990 NM_022006 NM_021902 BM673498 AI809210 CR617501 AW006222 
    AI084856 AW262746 AW297893 F33358 NM_005031 AJ573644 AI086449 BM662308 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FXYD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCAAGGCAG
    FXYD1 Expression
    About this image


    FXYD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Endothelial Cells Blood Brain Barrier
             Choroid Plexus
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
     
     Endothelium (Cardiovascular System)
             Endothelial Cells Blood Brain Barrier
    FXYD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FXYD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.442498

    UniProtKB/Swiss-Prot: PLM_HUMAN, O00168
    Tissue specificity: Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung,
    liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining. Very low levels in
    kidney, colon and small intestine without mucosa, prostate without endothelial lining, spleen, and testis

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FXYD1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fxyd11 , 5 FXYD domain-containing ion transport regulator 11, 5 84.42(n)1
    82.61(a)1
      7 (19.29 cM)5
    561881  NM_194321.21  NP_919302.11 
     310516815 
    lizard
    (Anolis carolinensis)
    Reptilia FXYD16
    FXYD domain containing ion transport regulator 1
    66(a)
    1 ↔ 1
    GL343276.1(196397-204183)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.139492 Transcribed sequence with weak similarity to protein more 72.73(n)    CF378162.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fxyd6l6
    FXYD domain containing ion transport regulator 6 l...
    35(a)
    many ↔ many
    16(26840437-26882108) ENSDARG00000097057


    ENSEMBL Gene Tree for FXYD1 (if available)
    TreeFam Gene Tree for FXYD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FXYD1 gene
    FXYD62  FXYD6-FXYD22  
    5 SIMAP similar genes for FXYD1 using alignment to 3 protein entries:     PLM_HUMAN (see all proteins):
    FXYD7    FXYD3    FXYD2    FXYD6P3    FXYD6

    Find genes that share paralogs with FXYD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FXYD1 (see all 93)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs730419871,2
    C--35628261(+) GGTTTC/TGGAAT 1 -- us2k10--------
    rs1856708651,2
    --35628369(+) CTGCTC/TTTGTG 1 -- us2k10--------
    rs1918199471,2
    --35628389(+) GAGAGC/TGGCGG 1 -- us2k10--------
    rs1385767691,2
    C--35628541(+) TGTTTC/TTGTTT 2 -- us2k10--------
    rs1416679851,2
    C--35628612(+) TGCAAC/GCTCTG 2 -- us2k10--------
    rs1443368221,2
    --35628655(+) CCTCCA/GGAGTA 2 -- us2k10--------
    rs1487817621,2
    --35628756(+) TGTTGA/GACTCC 2 -- us2k10--------
    rs129801341,2
    C,F--35628782(+) CTCCCA/GCCTTG 2 -- us2k15Minor allele frequency- G:0.40NA 10
    rs1176271231,2
    C,F--35628845(+) TGGCCA/GTGCAT 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1168752131,2
    C,F--35628933(+) ACATGC/AATTTT 2 -- us2k11Minor allele frequency- A:0.02NA 120

    HapMap Linkage Disequilibrium report for FXYD1 (35629712 - 35634013 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FXYD1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718490CNV Deletion23290073
    nsv911617CNV Loss21882294
    dgv3849n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602359    OMIM disorders: --

    1 disease for FXYD1:    
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    spinal cord injury

    1 disease from the University of Copenhagen DISEASES database for FXYD1:
    Sleep disorder

    Find genes that share disorders with FXYD1           About GenesLikeMe


    Export disorders for FXYD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FXYD1 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with FXYD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1. (PubMed id 9169143)1, 2, 3 Chen L.-S.K.... Cuddy M. (Genomics 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Phospholemman is a substrate for myotonic dystrophy protein kinase. (PubMed id 10811636)1, 2 Mounsey J.P.... Moorman J.R. (J. Biol. Chem. 2000)
    4. The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. (PubMed id 10950925)1, 2 Sweadner K.J. and Rael E. (Genomics 2000)
    5. Novel regulation of cardiac Na pump via phospholemman. (PubMed id 23672825)1 Pavlovic D....Shattock M.J. (J. Mol. Cell. Cardiol. 2013)
    6. Coordinated regulation of cardiac Na(+)/Ca (2+) exchanger and Na (+)-K (+)-ATPase by phospholemman (FXYD1). (PubMed id 23224879)1 Cheung J.Y....Wang J. (Adv. Exp. Med. Biol. 2013)
    7. Intracellular trafficking of FXYD1 (phospholemman) and FXYD7 proteins in Xenopus oocytes and mammalian cells. (PubMed id 22535957)1 Moshitzky S....Garty H. (J. Biol. Chem. 2012)
    8. Influence of chronic and acute spinal cord injury on skeletal muscle Na+-K+-ATPase and phospholemman expression in humans. (PubMed id 22275761)1 Boon H....Chibalin A.V. (Am. J. Physiol. Endocrinol. Metab. 2012)
    9. Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. (PubMed id 21849407)1 El-Armouche A....Pavlovic D. (FASEB J. 2011)
    10. The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. (PubMed id 21868384)2 Tulloch L.B.... Fuller W. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5348 HGNC: 4025 AceView: FXYD1andFXYD7 Ensembl:ENSG00000266964 euGenes: HUgn5348
    ECgene: FXYD1 H-InvDB: FXYD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FXYD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FXYD1 gene:
    Search GeneIP for patents involving FXYD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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