Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FXR2 Gene

protein-coding   GIFtS: 59
GCID: GC17M007494

fragile X mental retardation, autosomal homolog 2


(Previous symbol: FMR1L2)
 Explore 9 diseases affiliated with
FXR2 via our new
 Human Malady Compendium 
Biological research products
for FXR2
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fragile X Mental Retardation, Autosomal Homolog 21 2
FMR1L21 2 3
FXR2P2
Fragile X Mental Retardation Syndrome-Related Protein 22
Fragile X-Mental Retardation 1-Like 22

External Ids:    HGNC: 40241   Entrez Gene: 95132   Ensembl: ENSG000001292457   OMIM: 6053395   UniProtKB: P511163   

Export aliases for FXR2 gene to outside databases

Previous GC identifers: GC17M007908 GC17M008234 GC17M007437 GC17M007695 GC17M007435 GC17M007388


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FXR2:
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar
to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded
protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental
retardation syndrome. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FXR2_HUMAN, P51116
Function: RNA-binding protein

Gene Wiki entry for FXR2


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010718.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FXR2 gene promoter:
         COUP-TF1   PPAR-gamma1   COUP-TF   COUP   PPAR-gamma2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for FXR2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.3

FXR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXR2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007494:  view genomic region     (about GC identifiers)

Start:
7,494,548 bp from pter      End:
7,518,215 bp from pter
Size:
23,668 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FXR2_HUMAN, P51116 (See protein sequence)
Recommended Name: Fragile X mental retardation syndrome-related protein 2  
Size: 673 amino acids; 74223 Da
Subunit: Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for FXR2:
3H8Z (3D)    
Secondary accessions: B2R9M2 D3DTQ1 Q86V09 Q8WUM2

Explore the universe of human proteins at neXtProt for FXR2: NX_P51116

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51116

  • FXR2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_004851.2  
    ENSEMBL proteins: 
     ENSP00000250113   ENSP00000459230  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for FXR2 
    GenScript Custom Purified and Recombinant Proteins Services for FXR2
    Novus Biologicals FXR2 Protein
    Novus Biologicals FXR2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FXR2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0022625cytosolic large ribosomal subunit TAS9259278


    FXR2 for ontologies           About GeneDecksing



    FXR2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of FXR2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for FXR2 
    OriGene Antibodies: FXR2
    OriGene Custom Antibody Services for FXR2 
    GenScript Custom Superior Antibodies Services for FXR2
    Novus Biologicals FXR2 Antibodies
    Search for Antibodies for FXR2 at Abcam  
    Uscn Antibodies for FXR2
    ThermoFisher Antibodies for FXR2

    Assay Products for FXR2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FXR2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for FXR2


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FXR2 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR004087 KH_dom
     IPR008395 Agenet-like_dom
     IPR022034 Frag_X_MRP_fam
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry P51116

    ProtoNet protein and cluster: P51116

    3 Blocks protein families:
    IPB004087 KH domain
    IPB004088 KH
    IPB008395 Agenet


    UniProtKB/Swiss-Prot: FXR2_HUMAN, P51116
    Domain: The tandem Tudor domains preferentially recognize trimethylated histone peptides
    Similarity: Belongs to the FMR1 family
    Similarity: Contains 2 Agenet-like domains
    Similarity: Contains 2 KH domains


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FXR2_HUMAN, P51116
    Function: RNA-binding protein

         Genatlas biochemistry entry for FXR2:
    cytoplasmic RNA binding protein (74kDa),homologous to FXR1 and FMR1 (see symbols),homodimerizing and heterodimerizing
    with them,expressed in fetal and adult brain and testis,shuttling between cytoplasm and nucleolus

    miRNA
    Products:
        
    miRTarBase miRNAs that target FXR2:
    hsa-mir-30a (MIRT005207)

    OriGene 3'-UTR Clone: FXR2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FXR2
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate FXR2 (see all 52):
    hsa-miR-124* hsa-miR-1321 hsa-miR-4254 hsa-miR-429 hsa-miR-1224-3p hsa-miR-485-3p hsa-miR-1260b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidFXR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FXR2 (see all 7)
    OriGene shRNA RFP: FXR2
    OriGene siRNA: FXR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FXR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FXR2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXR2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXR2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FXR2 (NM_004860)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FXR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXR2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FXR2
    Search LifeMap BioReagents cell lines for FXR2

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXR2

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI19060904


    FXR2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fxr2tm1Cgr for FXR2
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fxr2):
     behavior/neurological  integument  nervous system  reproductive system 

    FXR2 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    Neuroscience1.00
    2Translational Control
    Translational Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for FXR2
        Translational Control
    Neuroscience



    FXR2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FXR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/213 Interacting proteins for FXR2 (P511161, 2, 3 ENSP000002501134) via UniProtKB, MINT, STRING, and/or I2D (see all 213)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6IP1Q150411, 2, 3, ENSP000003067884EBI-740459,EBI-714543 MINT-67910 I2D: score=5 STRING: ENSP00000306788
    LDOC1O957511, 2, 3, ENSP000003595574EBI-740459,EBI-740738 MINT-67665 I2D: score=5 STRING: ENSP00000359557
    MBIPQ9NS731, 2, 3, ENSP000003244444EBI-740459,EBI-741953 MINT-67977 I2D: score=5 STRING: ENSP00000324444
    PAICSP222341, 2, 3, ENSP000003825954EBI-740459,EBI-712261 MINT-66967 I2D: score=5 STRING: ENSP00000382595
    RABAC1Q9UI141, 2, 3, ENSP000002220084EBI-740459,EBI-712367 MINT-66878 I2D: score=5 STRING: ENSP00000222008
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FXR2
    Search CenterWatch for drugs/clinical trials and news about FXR2 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FXR2 gene: 
    NM_004860.3  

    Unigene Cluster for FXR2:

    Fragile X mental retardation, autosomal homolog 2
    Hs.52788  [show with all ESTs]
    Unigene Representative Sequence: NM_004860
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250113(uc002gia.2) ENST00000573057 ENST00000571079 ENST00000573957
    ENST00000574490 ENST00000576693 ENST00000571597

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: FXR2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FXR2
    8/52 QIAGEN miScript miRNA Assays for microRNAs that regulate FXR2 (see all 52):
    hsa-miR-124* hsa-miR-1321 hsa-miR-4254 hsa-miR-429 hsa-miR-1224-3p hsa-miR-485-3p hsa-miR-1260b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidFXR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FXR2 (see all 7)
    OriGene shRNA RFP: FXR2
    OriGene siRNA: FXR2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FXR2
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXR2 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXR2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: FXR2 (NM_004860)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FXR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXR2 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FXR2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FXR2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXR2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXR2

    Additional cDNA sequence: 

    AK226082.1 AK313836.1 BC020090.1 BC051907.1 BC067272.1 BT009817.1 U31501.1 

    14 DOTS entries:

    DT.100789796  DT.100694592  DT.445102  DT.95109491  DT.100789795  DT.75150796  DT.216811  DT.120901425 
    DT.120901432  DT.100789791  DT.120901665  DT.120901713  DT.95257709  DT.40113521 

    24/242 AceView cDNA sequences (see all 242):

    AI861941 CK903942 CB149898 CD358923 AL550222 BM981896 BP359839 AA679089 
    AL046046 BQ961630 T30226 BF002351 BF528306 CA433256 BE549798 BG575964 
    BM694084 BU728005 BC067272 BQ632123 BE301990 BI916875 BX281717 AA864776 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FXR2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                                              -                                                                                       
    SP2:                                                              -                                                                                       
    SP3:                                                              -                                                                                       
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                      -               


    ECgene alternative splicing isoforms for FXR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FXR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCTCACAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FXR2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FXR2

    SOURCE GeneReport for Unigene cluster: Hs.52788
        SABiosciences Custom PCR Arrays for FXR2
    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FXR2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FXR2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXR2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FXR2 gene from 3/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia FXR26
    FXR26
    --
    86(a)
    49(a)
    possible ortholog
    1 ↔ 1
    AAWZ02039987(2451-6966)
    GL344205.1(2889-33838)
    zebrafish
    (Danio rerio)
    Actinopterygii fxr21 fragile X mental retardation, autosomal homolog 2 67.39(n)
    70.83(a)
      393180  NM_200211.2  NP_956505.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fmr13 negative regulation of translation mRNA
    binding
    47(a)     --


    ENSEMBL Gene Tree for FXR2 (if available)
    TreeFam Gene Tree for FXR2 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FXR2 gene
    FMR12  FXR12  
    2 SIMAP similar genes for FXR2 using alignment to 3 protein entries:     FXR2_HUMAN (see all proteins):
    FXR1    FMR1

    FXR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/348 NCBI SNPs in FXR2 are shown (see all 348    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1845136511,2
    C,--7495804(+) TCTGGA/TGTCCA 1 -- int10--------
    rs1878109981,2
    C,--7495830(+) GCTGGC/GGGTCT 2 P R mis10--------
    rs360135551,2
    C,F--7495875(-) CCGCCG/CCCGTA 2 /P /R mis13Minor allele frequency- C:0.11NA 60
    rs1931294271,2
    --7495966(+) CCCTCA/GATTCC 1 -- int10--------
    rs1855823201,2
    C,--7496035(+) TGTTGA/GGCCCA 2 P L mis10--------
    rs1997419161,2
    C,--7496096(+) GCGGCA/GGGAGC 2 R C mis10--------
    rs1381434921,2
    --7496124(+) GCTGGG/TGGGGG 2 P syn10--------
    rs2000237161,2
    C--7496152(+) CAACCG/AGGGGC 2 /P /L mis11Minor allele frequency- A:0.00EU 569
    rs2011948891,2
    C,F--7496382(+) TCGGCC/TGCCTC 2 Q R mis11Minor allele frequency- T:0.01EU 569
    rs617308431,2
    C,F,--7496411(+) GTTGGG/AGGATC 2 /P syn12Minor allele frequency- A:0.01NS EU 641

    HapMap Linkage Disequilibrium report for FXR2 (7494548 - 7518215 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FXR2: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FXR2
    DNA2.0 Custom Variant and Variant Library Synthesis for FXR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FXR2 for disorders           About GeneDecksing

    OMIM gene information: 605339    OMIM disorders: --

    9 diseases for FXR2:    About MalaCards
    mental retardation syndrome    incontinentia pigmenti achromians    fragile x syndrome    megakaryoblastic leukemia
    acute megakaryoblastic leukemia    intellectual disability    leukemia    ataxia
    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for FXR2:
    Fragile X syndrome     Intellectual disability

    2 Novoseek disease relationships for FXR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fragile x syndrome 84.3 1 10446811 (1)
    mental retardation 73.3 4 7489725 (2), 11178106 (1)


    Export disorders for FXR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FXR2 gene, integrated from 9 sources (see all 53):
    (articles sorted by number of sources associating them with FXR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. (PubMed id 7489725)1, 2, 3, 9 Zhang Y.... Dreyfuss G. (1995)
    2. Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis. (PubMed id 9259278)1, 3, 9 Tamanini F....Hoogeveen A.T. (1997)
    3. Structural studies of the tandem Tudor domains of fra gile X mental retardation related proteins FXR1 and FXR2. (PubMed id 21072162)1, 2 Adams-Cioaba M.A....Min J. (2010)
    4. Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. (PubMed id 18664458)1, 2 Linder B.... Fischer U. (2008)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap. (PubMed id 9437788)1, 2 Joseph D.R. (1998)
    9. Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. (PubMed id 8668200)1, 9 Siomi M.C....Dreyfuss G. (1996)
    10. Genome-wide association study of circulating estradiol , testosterone, and sex hormone-binding globulin in postmenopausal women. (PubMed id 22675492)1 Prescott J....De Vivo I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9513 HGNC: 4024 AceView: FXR2 Ensembl:ENSG00000129245 euGenes: HUgn9513
    ECgene: FXR2 H-InvDB: FXR2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FXR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FXR2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FXR2 gene:
    Search GeneIP for patents involving FXR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FXR2
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for FXR2   OriGene shRNA RFP for FXR2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FXR2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FXR2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for FXR2   OriGene 3'-UTR Clone for FXR2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FXR2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FXR2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FXR2   OriGene Custom Protein Services for FXR2  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FXR2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FXR2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FXR2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FXR2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FXR2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FXR2
     GenScript Custom Purified and Recombinant Proteins Services for FXR2 GenScript cDNA clones with any tag delivered in your preferred vector for FXR2
     GenScript Custom Assay Services for FXR2 GenScript Custom Superior Antibodies Services for FXR2
     GenScript Custom overexpressing Cell Line Services for FXR2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for FXR2 

     Regulatory tfbs in FXR2 promoter
     Search Chromatin IP Primers for FXR2
     RT2 qPCR Primer Assay in human, mouse, rat FXR2
     GNC Network for FXR2
     SABiosciences Custom PCR Arrays for FXR2
     Search Tocris compounds for FXR2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     FXR2 antibodies
     FXR2 proteins
     FXR2 lysates
     Search for Antibodies for FXR2 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for FXR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     FXR2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for FXR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXR2
     SwitchGear 3'UTR luciferase reporter plasmids for FXR2
     Browse SwitchGear Promoter luciferase reporter plasmids for FXR2
     ThermoFisher Antibodies for FXR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXR2
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FXR2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4