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Aliases for FXR2 Gene

Aliases for FXR2 Gene

  • FMR1 Autosomal Homolog 2 2 3 5
  • Fragile X Mental Retardation, Autosomal Homolog 2 2 3
  • FMR1L2 3 4
  • Fragile X Mental Retardation Syndrome-Related Protein 2 3
  • Fragile X-Mental Retardation 1-Like 2 3
  • FXR2P 3

External Ids for FXR2 Gene

Previous HGNC Symbols for FXR2 Gene

  • FMR1L2

Previous GeneCards Identifiers for FXR2 Gene

  • GC17M007908
  • GC17M008234
  • GC17M007437
  • GC17M007695
  • GC17M007435
  • GC17M007494
  • GC17M007388

Summaries for FXR2 Gene

Entrez Gene Summary for FXR2 Gene

  • The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq, Jul 2008]

GeneCards Summary for FXR2 Gene

FXR2 (FMR1 Autosomal Homolog 2) is a Protein Coding gene. Diseases associated with FXR2 include Fragile X Syndrome and X-Linked Disease. Among its related pathways are Neuroscience and RNA transport. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is FXR1.

UniProtKB/Swiss-Prot for FXR2 Gene

  • RNA-binding protein.

Gene Wiki entry for FXR2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FXR2 Gene

Genomics for FXR2 Gene

Regulatory Elements for FXR2 Gene

Enhancers for FXR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FXR2 on UCSC Golden Path with GeneCards custom track

Promoters for FXR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FXR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FXR2 Gene

Chromosome:
17
Start:
7,591,230 bp from pter
End:
7,614,897 bp from pter
Size:
23,668 bases
Orientation:
Minus strand

Genomic View for FXR2 Gene

Genes around FXR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FXR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FXR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FXR2 Gene

Proteins for FXR2 Gene

  • Protein details for FXR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51116-FXR2_HUMAN
    Recommended name:
    Fragile X mental retardation syndrome-related protein 2
    Protein Accession:
    P51116
    Secondary Accessions:
    • B2R9M2
    • D3DTQ1
    • Q86V09
    • Q8WUM2

    Protein attributes for FXR2 Gene

    Size:
    673 amino acids
    Molecular mass:
    74223 Da
    Quaternary structure:
    • Interacts with FMR1 (PubMed:7489725, PubMed:8668200, PubMed:11157796). Interacts with FXR1 (PubMed:7489725). Interacts with TDRD3 (PubMed:18664458). Interacts with CYFIP2 but not with CYFIP1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for FXR2 Gene

neXtProt entry for FXR2 Gene

Post-translational modifications for FXR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FXR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FXR2 Gene

Domains & Families for FXR2 Gene

Protein Domains for FXR2 Gene

Suggested Antigen Peptide Sequences for FXR2 Gene

Graphical View of Domain Structure for InterPro Entry

P51116

UniProtKB/Swiss-Prot:

FXR2_HUMAN :
  • The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.
  • Belongs to the FMR1 family.
Domain:
  • The tandem Agenet-like domains preferentially recognize trimethylated histone peptides.
  • Contains 2 Agenet-like domains.
  • Contains 2 KH domains.
Family:
  • Belongs to the FMR1 family.
genes like me logo Genes that share domains with FXR2: view

No data available for Gene Families for FXR2 Gene

Function for FXR2 Gene

Molecular function for FXR2 Gene

GENATLAS Biochemistry:
cytoplasmic RNA binding protein (74kDa),homologous to FXR1 and FMR1 (see symbols),homodimerizing and heterodimerizing with them,expressed in fetal and adult brain and testis,shuttling between cytoplasm and nucleolus
UniProtKB/Swiss-Prot Function:
RNA-binding protein.

Gene Ontology (GO) - Molecular Function for FXR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding TAS 7489725
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 7489725
GO:0042802 identical protein binding IPI 16189514
GO:0042803 protein homodimerization activity IDA 7489725
genes like me logo Genes that share ontologies with FXR2: view
genes like me logo Genes that share phenotypes with FXR2: view

Animal Models for FXR2 Gene

MGI Knock Outs for FXR2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FXR2

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FXR2 Gene

Localization for FXR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FXR2 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FXR2 Gene COMPARTMENTS Subcellular localization image for FXR2 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5

Gene Ontology (GO) - Cellular Components for FXR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IDA 7489725
GO:0005844 polysome IBA --
GO:0016020 membrane IDA 19946888
GO:0022625 cytosolic large ribosomal subunit TAS 9259278
genes like me logo Genes that share ontologies with FXR2: view

Pathways & Interactions for FXR2 Gene

genes like me logo Genes that share pathways with FXR2: view

Pathways by source for FXR2 Gene

2 Cell Signaling Technology pathways for FXR2 Gene
1 KEGG pathway for FXR2 Gene

Gene Ontology (GO) - Biological Process for FXR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002230 positive regulation of defense response to virus by host IMP 22020285
GO:0017148 negative regulation of translation IBA --
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with FXR2: view

No data available for SIGNOR curated interactions for FXR2 Gene

Drugs & Compounds for FXR2 Gene

No Compound Related Data Available

Transcripts for FXR2 Gene

Unigene Clusters for FXR2 Gene

Fragile X mental retardation, autosomal homolog 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for FXR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FXR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
SP1: -
SP2: -
SP3: -
SP4:
SP5: -
SP6:
SP7:

Relevant External Links for FXR2 Gene

GeneLoc Exon Structure for
FXR2
ECgene alternative splicing isoforms for
FXR2

Expression for FXR2 Gene

mRNA expression in normal human tissues for FXR2 Gene

mRNA differential expression in normal tissues according to GTEx for FXR2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for FXR2 Gene

This gene is overexpressed in Testis (19.4), Peripheral blood mononuclear cells (10.8), and Urine (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FXR2 Gene



Protein tissue co-expression partners for FXR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FXR2 Gene:

FXR2

SOURCE GeneReport for Unigene cluster for FXR2 Gene:

Hs.52788
genes like me logo Genes that share expression patterns with FXR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for FXR2 Gene

Orthologs for FXR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FXR2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FXR2 34
  • 93.46 (n)
  • 98.51 (a)
FXR2 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FXR2 34
  • 91.47 (n)
  • 97.02 (a)
FXR2 35
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fxr2 34
  • 90.77 (n)
  • 97.77 (a)
Fxr2 16
Fxr2 35
  • 65 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FXR2 34
  • 99.9 (n)
  • 99.85 (a)
FXR2 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fxr2 34
  • 90.99 (n)
  • 97.47 (a)
oppossum
(Monodelphis domestica)
Mammalia FXR2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FXR2 35
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FXR2 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fxr2 34
  • 66.67 (n)
  • 69.71 (a)
fxr2 35
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Fmr1 36
  • 47 (a)
Fmr1 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
Species where no ortholog for FXR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FXR2 Gene

ENSEMBL:
Gene Tree for FXR2 (if available)
TreeFam:
Gene Tree for FXR2 (if available)

Paralogs for FXR2 Gene

Paralogs for FXR2 Gene

(2) SIMAP similar genes for FXR2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FXR2: view

Variants for FXR2 Gene

Sequence variations from dbSNP and Humsavar for FXR2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs36013555 - 7,592,557(-) CCGCC(A/C/G)CCGTA nc-transcript-variant, reference, missense
rs17854734 - 7,595,899(+) GCCTG(A/C)TGGAT nc-transcript-variant, reference, missense
rs858523 -- 7,608,211(-) ttgga(A/G)gctaa intron-variant
rs858524 -- 7,607,969(-) tctta(A/G)aaata intron-variant
rs858525 -- 7,596,073(-) CCTTA(C/T)TTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FXR2 Gene

Variant ID Type Subtype PubMed ID
esv2422288 CNV deletion 17116639
nsv1123093 CNV deletion 24896259
nsv1134593 CNV deletion 24896259
nsv457659 CNV loss 19166990
nsv574322 CNV loss 21841781

Variation tolerance for FXR2 Gene

Residual Variation Intolerance Score: 43.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.25; 25.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FXR2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FXR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FXR2 Gene

Disorders for FXR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FXR2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fragile x syndrome
  • fragile x mental retardation syndrome
x-linked disease
specific developmental disorder
- elite association - COSMIC cancer census association via MalaCards
Search FXR2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FXR2

Genetic Association Database (GAD)
FXR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FXR2
genes like me logo Genes that share disorders with FXR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FXR2 Gene

Publications for FXR2 Gene

  1. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. (PMID: 7489725) Zhang Y. … Dreyfuss G. (EMBO J. 1995) 2 3 4 22 65
  2. Evidence that fragile X mental retardation protein is a negative regulator of translation. (PMID: 11157796) Laggerbauer B. … Fischer U. (Hum. Mol. Genet. 2001) 3 4 22 65
  3. Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis. (PMID: 9259278) Tamanini F. … Hoogeveen A.T. (Hum. Mol. Genet. 1997) 2 3 22 65
  4. Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. (PMID: 8668200) Siomi M.C. … Dreyfuss G. (Mol. Cell. Biol. 1996) 3 4 22 65
  5. Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. (PMID: 21072162) Adams-Cioaba M.A. … Min J. (PLoS ONE 2010) 3 4 65

Products for FXR2 Gene

Sources for FXR2 Gene

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