Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FXR2 Gene

protein-coding   GIFtS: 65
GCID: GC17M007494

Fragile X Mental Retardation, Autosomal Homolog 2


(Previous symbol: FMR1L2)
  See FXR2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fragile X Mental Retardation, Autosomal Homolog 21 2
FMR1L21 2 3
FXR2P2
Fragile X Mental Retardation Syndrome-Related Protein 22
Fragile X-Mental Retardation 1-Like 22

External Ids:    HGNC: 40241   Entrez Gene: 95132   Ensembl: ENSG000001292457   OMIM: 6053395   UniProtKB: P511163   

Export aliases for FXR2 gene to outside databases

Previous GC identifers: GC17M007908 GC17M008234 GC17M007437 GC17M007695 GC17M007435 GC17M007388


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FXR2 Gene:
The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is
similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This
encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of
fragile X mental retardation syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for FXR2 Gene:
FXR2 (fragile X mental retardation, autosomal homolog 2) is a protein-coding gene. Diseases associated with FXR2 include mental retardation. GO annotations related to this gene include RNA binding and identical protein binding. An important paralog of this gene is FMR1.

UniProtKB/Swiss-Prot: FXR2_HUMAN, P51116
Function: RNA-binding protein

Gene Wiki entry for FXR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FXR2 gene promoter:
         COUP-TF1   PPAR-gamma1   COUP-TF   COUP   PPAR-gamma2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FXR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FXR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.3

FXR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FXR2 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M007494:  view genomic region     (about GC identifiers)

Start:
7,494,548 bp from pter      End:
7,518,215 bp from pter
Size:
23,668 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FXR2_HUMAN, P51116 (See protein sequence)
Recommended Name: Fragile X mental retardation syndrome-related protein 2  
Size: 673 amino acids; 74223 Da
Subunit: Interacts with FMR1 and FXR1. Interacts with CYFIP2 but not with CYFIP1. Interacts with TDRD3
1 PDB 3D structure from and Proteopedia for FXR2:
3H8Z (3D)    
Secondary accessions: B2R9M2 D3DTQ1 Q86V09 Q8WUM2

Explore the universe of human proteins at neXtProt for FXR2: NX_P51116

Explore proteomics data for FXR2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys320
  • Modification sites at PhosphoSitePlus

  • See FXR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004851.2  
    ENSEMBL proteins: 
     ENSP00000250113   ENSP00000459230  

    FXR2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FXR2
    GenScript Custom Purified and Recombinant Proteins Services for FXR2
    Novus Biologicals FXR2 Protein
    Novus Biologicals FXR2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FXR2

     
    Search eBioscience for Proteins for FXR2 

     
    antibodies-online proteins for FXR2 (4 products) 

     
    antibodies-online peptides for FXR2

    FXR2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FXR2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for FXR2 
    OriGene Antibodies for FXR2
    OriGene Custom Antibody Services for FXR2
    Novus Biologicals FXR2 Antibodies
    Abcam antibodies for FXR2
    Cloud-Clone Corp. Antibodies for FXR2
    ThermoFisher Antibodies for FXR2
    antibodies-online antibodies for FXR2 (54 products) 

    FXR2 Assay Products:

    EMD Millipore Kits and Assays for the Analysis of FXR2
    OriGene Custom Assay Services for FXR2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FXR2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FXR2
    Cloud-Clone Corp. CLIAs for FXR2
    Search eBioscience for ELISAs for FXR2 
    antibodies-online kits for FXR2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    4 InterPro protein domains:
     IPR004087 KH_dom
     IPR008395 Agenet-like_dom
     IPR022034 Frag_X_MRP_fam
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry P51116

    ProtoNet protein and cluster: P51116

    3 Blocks protein domains:
    IPB004087 KH domain
    IPB004088 KH
    IPB008395 Agenet


    UniProtKB/Swiss-Prot: FXR2_HUMAN, P51116
    Domain: The tandem Tudor domains preferentially recognize trimethylated histone peptides
    Similarity: Belongs to the FMR1 family
    Similarity: Contains 2 Agenet-like domains
    Similarity: Contains 2 KH domains


    Find genes that share domains with FXR2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FXR2_HUMAN, P51116
    Function: RNA-binding protein

         Genatlas biochemistry entry for FXR2:
    cytoplasmic RNA binding protein (74kDa),homologous to FXR1 and FMR1 (see symbols),homodimerizing and
    heterodimerizing with them,expressed in fetal and adult brain and testis,shuttling between cytoplasm and
    nucleolus

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding TAS7489725
    GO:0005515protein binding IPI16189514
    GO:0042802identical protein binding IPI16189514
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with FXR2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fxr2):
     behavior/neurological  integument  nervous system  reproductive system 

    Find genes that share phenotypes with FXR2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fxr2tm1Cgr for FXR2

       genOway: Develop your customized and physiologically relevant rodent model for FXR2

    miRNA
    Products:
        
    miRTarBase miRNAs that target FXR2:
    hsa-let-7b-5p (MIRT052187), hsa-mir-17-5p (MIRT051023), hsa-mir-324-3p (MIRT042893), hsa-mir-30a-5p (MIRT005207), hsa-mir-196a-5p (MIRT048260)

    Block miRNA regulation of human, mouse, rat FXR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FXR2 (see all 52):
    hsa-miR-124* hsa-miR-1321 hsa-miR-4254 hsa-miR-429 hsa-miR-1224-3p hsa-miR-485-3p hsa-miR-1260b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidFXR2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FXR2
    Predesigned siRNA for gene silencing in human, mouse, rat FXR2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FXR2

    Clone
    Products:
         
    OriGene clones in human, mouse for FXR2 (see all 6)
    OriGene ORF clones in mouse, rat for FXR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FXR2 (NM_004860)
    Sino Biological Human cDNA Clone for FXR2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FXR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXR2
    Addgene plasmids for FXR2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FXR2
    Browse ESI BIO Cell Lines and PureStem Progenitors for FXR2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXR2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FXR2_HUMAN, P51116: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0022625cytosolic large ribosomal subunit TAS9259278

    Find genes that share ontologies with FXR2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FXR2 About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2RNA transport
    RNA transport
    3Neuroscience
    Neuroscience


    Find genes that share SuperPaths with FXR2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for FXR2
        Translational Control
    Neuroscience



    1 Kegg Pathway  (Kegg details for FXR2):
        RNA transport

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FXR2
    Interactions:

        GeneGlobe Interaction Network for FXR2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FXR2 (P511161, 2, 3 ENSP000002501134) via UniProtKB, MINT, STRING, and/or I2D (see all 232)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL6IP1Q150411, 2, 3, ENSP000003067884EBI-740459,EBI-714543 MINT-67910 I2D: score=5 STRING: ENSP00000306788
    LDOC1O957511, 2, 3, ENSP000003595574EBI-740459,EBI-740738 MINT-67665 I2D: score=5 STRING: ENSP00000359557
    MBIPQ9NS731, 2, 3, ENSP000003244444EBI-740459,EBI-741953 MINT-67977 I2D: score=5 STRING: ENSP00000324444
    PAICSP222341, 2, 3, ENSP000003825954EBI-740459,EBI-712261 MINT-66967 I2D: score=5 STRING: ENSP00000382595
    RABAC1Q9UI141, 2, 3, ENSP000002220084EBI-740459,EBI-712367 MINT-66878 I2D: score=5 STRING: ENSP00000222008
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FXR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FXR2 gene: 
    NM_004860.3  

    Unigene Cluster for FXR2:

    Fragile X mental retardation, autosomal homolog 2
    Hs.52788  [show with all ESTs]
    Unigene Representative Sequence: NM_004860
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250113(uc002gia.2) ENST00000573057 ENST00000571079 ENST00000573957
    ENST00000574490 ENST00000576693 ENST00000571597
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FXR2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FXR2 (see all 52):
    hsa-miR-124* hsa-miR-1321 hsa-miR-4254 hsa-miR-429 hsa-miR-1224-3p hsa-miR-485-3p hsa-miR-1260b hsa-miR-128
    SwitchGear 3'UTR luciferase reporter plasmidFXR2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FXR2
    Predesigned siRNA for gene silencing in human, mouse, rat FXR2
    Clone
    Products:
         
    OriGene clones in human, mouse for FXR2 (see all 6)
    OriGene ORF clones in mouse, rat for FXR2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FXR2 (NM_004860)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FXR2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXR2
    Addgene plasmids for FXR2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FXR2
    OriGene qSTAR qPCR primer pairs in human, mouse for FXR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FXR2
      QuantiTect SYBR Green Assays in human, mouse, rat FXR2
      QuantiFast Probe-based Assays in human, mouse, rat FXR2

    Additional mRNA sequence: 

    AK226082.1 AK313836.1 BC020090.1 BC051907.1 BC067272.1 BT009817.1 U31501.1 

    14 DOTS entries:

    DT.100789796  DT.100694592  DT.445102  DT.95109491  DT.100789795  DT.75150796  DT.216811  DT.120901425 
    DT.120901432  DT.100789791  DT.120901665  DT.120901713  DT.95257709  DT.40113521 

    Selected AceView cDNA sequences (see all 242):

    BC020090 BQ961630 CK903942 BE018376 BE549798 BM741423 BE876208 CD358923 
    BE301990 AI861941 AL550222 T30226 BP359839 CA433256 CB149898 BF002351 
    BX281717 AA864776 BE466645 BC067272 AL046046 BQ632123 BC051907 BU150652 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FXR2 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b
    SP1:                                                              -                                                                                       
    SP2:                                                              -                                                                                       
    SP3:                                                              -                                                                                       
    SP4:                                                                                                                                                      
    SP5:                                                                                                                                      -               


    ECgene alternative splicing isoforms for FXR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FXR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTCACAG
    FXR2 Expression
    About this image


    FXR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Myoblasts Mandibular Arch Muscles
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    FXR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FXR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.52788
        Custom PCR Arrays for FXR2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FXR2
    OriGene qSTAR qPCR primer pairs in human, mouse for FXR2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FXR2
    QuantiTect SYBR Green Assays in human, mouse, rat FXR2
    QuantiFast Probe-based Assays in human, mouse, rat FXR2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for FXR2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fxr21 , 5 fragile X mental retardation, autosomal homolog 21, 5 90.77(n)1
    97.77(a)1
      11 (42.86 cM)5
    238791  NM_011814.21  NP_035944.21 
     696329905 
    lizard
    (Anolis carolinensis)
    Reptilia FXR26
    fragile X mental retardation, autosomal homolog 2
    78(a)
    1 ↔ 1
    AAWZ02039987(21-7528)
    zebrafish
    (Danio rerio)
    Actinopterygii fxr21 fragile X mental retardation, autosomal homolog 2 66.67(n)
    69.71(a)
      393180  NM_200211.2  NP_956505.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fmr13 negative regulation of translation mRNA
    binding
    47(a)     --


    ENSEMBL Gene Tree for FXR2 (if available)
    TreeFam Gene Tree for FXR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FXR2 gene
    FMR12  FXR12  
    2 SIMAP similar genes for FXR2 using alignment to 3 protein entries:     FXR2_HUMAN (see all proteins):
    FXR1    FMR1

    Find genes that share paralogs with FXR2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FXR2 (see all 548)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512351121,2
    --7483325(+) AGGCCG/TGACCC 1 -- ds50010--------
    rs1404179451,2
    --7483380(+) CCCAAC/TGGCCC 1 -- ds50010--------
    rs1470074221,2
    --7483381(+) CCAACA/GGCCCA 1 -- ds50010--------
    rs1860598201,2
    --7483427(+) AGCCTG/TCCTTG 1 -- ds50010--------
    rs756193931,2
    F--7483554(+) AAGCAA/GCAAGG 1 -- ds50011Minor allele frequency- G:0.02EA 120
    rs1920925951,2
    --7483708(+) GGCCAC/GGGCAG 1 -- ds50010--------
    rs1135955291,2
    C--7483773(+) CAGACA/TGCCAT 1 -- ds50010--------
    rs1839854491,2
    --7483790(+) TTTTTC/TATTCT 1 -- ut310--------
    rs10481191,2
    C--7483982(-) CATTTC/TTGGGG 1 -- ut312Minor allele frequency- T:0.02MN NA 186
    rs781251301,2
    C,F--7484187(+) CAAGAG/AGGAGG 1 -- ut311Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for FXR2 (7494548 - 7518215 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for FXR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422288CNV Deletion17116639
    nsv457659CNV Loss19166990
    nsv907651CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FXR2
    DNA2.0 Custom Variant and Variant Library Synthesis for FXR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605339    OMIM disorders: --

    1 disease for FXR2:    
    About MalaCards
    mental retardation

    2 diseases from the University of Copenhagen DISEASES database for FXR2:
    Fragile X syndrome     Intellectual disability

    Find genes that share disorders with FXR2           About GenesLikeMe

    2 Novoseek inferred disease relationships for FXR2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fragile x syndrome 84.3 1 10446811 (1)
    mental retardation 73.3 4 7489725 (2), 11178106 (1)

    Genetic Association Database (GAD): FXR2

    Export disorders for FXR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FXR2 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with FXR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2. (PubMed id 7489725)1, 2, 3, 9 Zhang Y.... Dreyfuss G. (EMBO J. 1995)
    2. Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis. (PubMed id 9259278)1, 3, 9 Tamanini F....Hoogeveen A.T. (Hum. Mol. Genet. 1997)
    3. Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2. (PubMed id 21072162)1, 2 Adams-Cioaba M.A.... Min J. (PLoS ONE 2010)
    4. Tdrd3 is a novel stress granule-associated protein interacting with the Fragile-X syndrome protein FMRP. (PubMed id 18664458)1, 2 Linder B.... Fischer U. (Hum. Mol. Genet. 2008)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. The rat androgen-binding protein (ABP/SHBG) gene contains triplet repeats similar to unstable triplets: evidence that the ABP/SHBG and the fragile X-related 2 genes overlap. (PubMed id 9437788)1, 2 Joseph D.R. (Steroids 1998)
    9. Specific sequences in the fragile X syndrome protein FMR1 and the FXR proteins mediate their binding to 60S ribosomal subunits and the interactions among them. (PubMed id 8668200)1, 9 Siomi M.C....Dreyfuss G. (Mol. Cell. Biol. 1996)
    10. Identification of UHRF1/2 as new N-methylpurine DNA glycosylase-interacting proteins. (PubMed id 23537643)1 Liang C....Zhang L. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9513 HGNC: 4024 AceView: FXR2 Ensembl:ENSG00000129245 euGenes: HUgn9513
    ECgene: FXR2 Kegg: 9513 H-InvDB: FXR2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FXR2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FXR2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FXR2 gene:
    Search GeneIP for patents involving FXR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     EMD Millipore Kits and Assays for the Analysis of FXR2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FXR2
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FXR2   OriGene RNAi products in human, mouse, rat for FXR2  
     OriGene qPCR primer pairs and template standards for FXR2   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FXR2  
     OriGene qSTAR qPCR primer pairs in human, mouse for FXR2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FXR2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FXR2   OriGene Custom Protein Services for FXR2  

     
     
     Block miRNA regulation of human, mouse, rat FXR2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FXR2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FXR2 Predesigned siRNA for gene silencing in human, mouse, rat FXR2
     QuantiFast Probe-based Assays in human, mouse, rat FXR2 QuantiTect SYBR Green Assays in human, mouse, rat FXR2
     Custom PCR Arrays for FXR2 Search Chromatin IP Primers for FXR2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FXR2  GeneGlobe Interaction Network for FXR2
     Regulatory tfbs in FXR2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FXR2 GenScript cDNA clones with any tag delivered in your preferred vector for FXR2
     GenScript Custom Assay Services for FXR2 GenScript Custom overexpressing Cell Line Services for FXR2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for FXR2 

     Search Tocris compounds for FXR2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FXR2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FXR2 antibodies
     FXR2 proteins
     FXR2 lysates
     Antibodies for FXR2
     See all of Abcam's Antibodies, Kits and Proteins for FXR2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FXR2
     Antibodies for FXR2
     ELISAs for FXR2
     CLIAs for FXR2



     Browse ESI BIO Cell Lines and PureStem Progenitors for FXR2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FXR2
     SwitchGear 3'UTR luciferase reporter plasmids for FXR2
     Browse SwitchGear Promoter luciferase reporter plasmids for FXR2
     ThermoFisher Antibodies for FXR2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FXR2
     Browse compounds at ApexBio
     Addgene plasmids for FXR2
      Search eBioscience for proteins for FXR2
      Search eBioscience for elisas for FXR2
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FXR2
     antibodies-online antibodies for FXR2 (54 products)
     antibodies-online kits for FXR2 (4 products)
     antibodies-online peptides for FXR2
     antibodies-online proteins for FXR2 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FXR2 gene at Home site.
    Version: 3.12.250 16 Nov 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4