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FUZ Gene

protein-coding   GIFtS: 49
GCID: GC19M050310

Fuzzy Planar Cell Polarity Protein

(Previous name: fuzzy homolog (Drosophila))
  See FUZ-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fuzzy Planar Cell Polarity Protein1 2
FY2 3
NTD2 5
Fuzzy Homolog (Drosophila)1
Fuzzy Homolog2
Protein Fuzzy Homolog2

External Ids:    HGNC: 262191   Entrez Gene: 801992   Ensembl: ENSG000000103617   OMIM: 6106225   UniProtKB: Q9BT043   

Export aliases for FUZ gene to outside databases

Previous GC identifers: GC19M055002 GC19M046686


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FUZ Gene:
This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement.
Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are
associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this
gene. (provided by RefSeq, Jul 2012)

GeneCards Summary for FUZ Gene:
FUZ (fuzzy planar cell polarity protein) is a protein-coding gene. Diseases associated with FUZ include thoracolumbosacral spina bifida cystica, and lumbosacral spina bifida cystica.

UniProtKB/Swiss-Prot: FUZZY_HUMAN, Q9BT04
Function: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane
transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary
cilia (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FUZ gene promoter:
         Sp1   Hand1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUZ promoter sequence
   Search Chromatin IP Primers for FUZ

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUZ


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.33   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

FUZ Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUZ gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M050310:  view genomic region     (about GC identifiers)

Start:
50,310,123 bp from pter      End:
50,320,633 bp from pter
Size:
10,511 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FUZZY_HUMAN, Q9BT04 (See protein sequence)
Recommended Name: Protein fuzzy homolog  
Size: 418 amino acids; 45679 Da
Sequence caution: Sequence=AAH10092.1; Type=Frameshift; Positions=265;
Secondary accessions: B2RD86 B5MDH0 Q6PJY0 Q9H613
Alternative splicing: 3 isoforms:  Q9BT04-1   Q9BT04-2   Q9BT04-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FUZ: NX_Q9BT04

Explore proteomics data for FUZ at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys319

  • See FUZ Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001165408.1  NP_079405.2  

    ENSEMBL proteins: 
     ENSP00000433492   ENSP00000432148   ENSP00000435177   ENSP00000431731   ENSP00000431420  
     ENSP00000313309   ENSP00000366296   ENSP00000431388   ENSP00000470863   ENSP00000471793  
     ENSP00000433164   ENSP00000471319   ENSP00000469856   ENSP00000470155   ENSP00000408018  

    FUZ Human Recombinant Protein Products:

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    Novus Biologicals FUZ Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FUZ

     
    Search eBioscience for Proteins for FUZ 

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    Cloud-Clone Corp. ELISAs for FUZ
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    Search eBioscience for ELISAs for FUZ 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026069 Fuzzy

    Graphical View of Domain Structure for InterPro Entry Q9BT04

    ProtoNet protein and cluster: Q9BT04

    UniProtKB/Swiss-Prot: FUZZY_HUMAN, Q9BT04
    Similarity: Belongs to the fuzzy family


    Find genes that share domains with FUZ           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUZZY_HUMAN, Q9BT04
    Function: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane
    transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary
    cilia (By similarity)

    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 3 alleles(MGI details for Fuz) (see all 17):

     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     endocrine/exocrine gland  hearing/vestibular/ear  homeostasis/metabolism  limbs/digits/tail  liver/biliary system 
     mortality/aging  muscle  nervous system  pigmentation  respiratory system 

    Find genes that share phenotypes with FUZ           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FUZ
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FUZ

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FUZ
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FUZ

    miRNA
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    miRTarBase miRNAs that target FUZ:
    hsa-mir-484 (MIRT042014)

    Block miRNA regulation of human, mouse, rat FUZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FUZ (see all 14):
    hsa-miR-3149 hsa-miR-185* hsa-miR-181c hsa-miR-139-3p hsa-miR-452* hsa-miR-181a hsa-miR-3175 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidFUZ 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FUZ

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FUZ (NM_025129)
    Sino Biological Human cDNA Clone for FUZ
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUZ

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FUZ 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUZ


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FUZZY_HUMAN, Q9BT04: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with FUZ           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including FUZ: 
              Primary Cilia in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FUZ

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for FUZ (Q9BT043 ENSP000003133094) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FZD1Q9UP383, ENSP000002879344I2D: score=1 STRING: ENSP00000287934
    RSG1Q9BU203, ENSP000003647494I2D: score=4 STRING: ENSP00000364749
    CELSR1Q9NYQ63, ENSP000002627384I2D: score=1 STRING: ENSP00000262738
    CELSR2ENSP000002713324STRING: ENSP00000271332
    CELSR3ENSP000001640244STRING: ENSP00000164024
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001736establishment of planar polarity ISS--
    GO:0001843neural tube closure ISS--
    GO:0001942hair follicle development ISS--
    GO:0008589regulation of smoothened signaling pathway ISS--
    GO:0010172embryonic body morphogenesis ISS--

    Find genes that share ontologies with FUZ           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FUZ (FUZZY)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FUZ gene (2 alternative transcripts): 
    NM_001171937.1  NM_025129.4  

    Unigene Cluster for FUZ:

    Fuzzy planar cell polarity protein
    Hs.288800  [show with all ESTs]
    Unigene Representative Sequence: BF570244
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000525130 ENST00000529634 ENST00000528094 ENST00000533418 ENST00000525370
    ENST00000313777(uc002ppq.2 uc002ppt.2 uc002ppu.2) ENST00000377092
    ENST00000534138 ENST00000527973 ENST00000528043 ENST00000531017(uc010ybd.2)
    ENST00000527585 ENST00000534008 ENST00000529302 ENST00000526575 ENST00000525800
    ENST00000527111 ENST00000526435
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FUZ using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FUZ (see all 14):
    hsa-miR-3149 hsa-miR-185* hsa-miR-181c hsa-miR-139-3p hsa-miR-452* hsa-miR-181a hsa-miR-3175 hsa-miR-181d
    SwitchGear 3'UTR luciferase reporter plasmidFUZ 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FUZ
    Predesigned siRNA for gene silencing in human, mouse, rat FUZ
    Clone
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    OriGene clones in human, mouse for FUZ (see all 12)
    OriGene ORF clones in mouse, rat for FUZ
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): FUZ (NM_025129)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUZ
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUZ
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FUZ
    OriGene qSTAR qPCR primer pairs in human, mouse for FUZ
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FUZ
      QuantiTect SYBR Green Assays in human, mouse, rat FUZ
      QuantiFast Probe-based Assays in human, mouse, rat FUZ

    Additional mRNA sequence: 

    AK026341.1 AK057964.1 AK315445.1 BC004445.1 BC010092.2 BC016793.2 NR_033269.1 

    18 DOTS entries:

    DT.100878217  DT.450640  DT.100878207  DT.97795998  DT.100878209  DT.95101281  DT.100697175  DT.100878215 
    DT.91949742  DT.97812515  DT.121500022  DT.100878212  DT.100731895  DT.121499949  DT.91769030  DT.121499945 
    DT.121499974  DT.95101305 

    Selected AceView cDNA sequences (see all 128):

    CR607071 BG773982 CR621655 BE302787 BX361843 BC004445 AL527000 CR613541 
    NM_025129 CR609003 BC010092 CA428536 AL521311 BE746609 BP363419 AL583023 
    CB152506 BI821050 BI869985 BQ278002 AI129391 BU073247 CR592794 AK026341 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FUZ (see all 17)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d · 2e · 2f · 2g · 2h ^ 3 ^ 4a · 4b · 4c · 4d ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ·
    SP1:                                                        -                       -                             -                       -     -               
    SP2:                                                                                -                             -                       -     -               
    SP3:                                                                                -                             -                       -     -     -     -   
    SP4:                                                                          -     -                             -                       -     -               
    SP5:                                                                                -     -     -     -           -                       -     -               

    ExUns: 10c · 10d ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                                      
    SP2:                                                      
    SP3:  -     -                                             
    SP4:                                                      
    SP5:                                                      


    ECgene alternative splicing isoforms for FUZ

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FUZ expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTGTTAG
    FUZ Expression
    About this image

    FUZ Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FUZ Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.288800
        Pathway & Disease-focused RT2 Profiler PCR Array including FUZ: 
              Primary Cilia in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for FUZ
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FUZ
    QuantiTect SYBR Green Assays in human, mouse, rat FUZ
    QuantiFast Probe-based Assays in human, mouse, rat FUZ
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUZ

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FUZ gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fuz1 , 5 fuzzy homolog (Drosophila)1, 5 81.69(n)1
    87.23(a)1
      7 (28.99 cM)5
    703001  NM_027376.31  NP_081652.21 
     448960795 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    60(a)
    54(a)
    many → 1
    many → 1
    GL344519.1(18279-30280)
    6(80184805-80192746)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fuz1 fuzzy planar cell polarity protein 56.37(n)
    53.77(a)
      677733  NM_001040017.2  NP_001035106.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7970901 protein fuzzy homolog 53.59(n)
    49.74(a)
      797090  XM_001337507.2  XP_001337543.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fy1 fuzzy 45.73(n)
    32.85(a)
      34166  NM_001273321.1  NP_001260250.1 


    ENSEMBL Gene Tree for FUZ (if available)
    TreeFam Gene Tree for FUZ (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FUZ (see all 233)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1126571321,2
    C,F--50313796(+) CCAGGC/TGTGGT 3 -- int11Minor allele frequency- T:0.50WA 2
    rs558103571,2
    C--50314459(+) AAAAG-/AAAAAA 3 -- int13Minor allele frequency- A:0.17NA CSA 6
    rs118824631,2
    C,F,H--50316549(+) TCAGGC/TACCTC 3 -- ut51 nc-transcript-variant9Minor allele frequency- T:0.01NS EA NA WA 918
    rs1380106761,2
    C--50316645(+) TTTCTA/TGTTTC 3 -- us2k10--------
    rs1495133611,2
    --50316708(+) AAGGCA/GTTGCC 3 -- us2k10--------
    rs22869481,2
    C,F,H--50316754(+) CTAAAC/TGGAAA 3 -- us2k131Minor allele frequency- N:0.00EA NA MN NS WA 5732
    rs1442685761,2
    --50316934(+) GGCTGC/TAAACA 3 -- us2k10--------
    rs1500946251,2
    C--50317081(+) AAAAG-/GTTGTTTT 3 -- us2k10--------
    rs2014715271,2
    --50317107(+) AAGAA-/AACAAGGA 3 -- us2k10--------
    rs1169434881,2
    C,F--50317108(+) AGAAAA/GCAAGG 3 -- us2k11Minor allele frequency- G:0.03NA 120

    HapMap Linkage Disequilibrium report for FUZ (50310123 - 50320633 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FUZ:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912269CNV Loss21882294
    nsv912272CNV Loss21882294
    dgv53n68CNV Loss17160897
    nsv470150CNV Gain18288195
    nsv9739CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): FUZ
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FUZ
    DNA2.0 Custom Variant and Variant Library Synthesis for FUZ

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610622   
    OMIM disorders: 182940  
    16 diseases for FUZ:    
    About MalaCards
    thoracolumbosacral spina bifida cystica    lumbosacral spina bifida cystica    upper thoracic spina bifida aperta    cervical spina bifida aperta
    upper thoracic spina bifida cystica    total spina bifida cystica    chiari malformation type 2    total spina bifida aperta
    cervical spina bifida cystica    cervicothoracic spina bifida aperta    lumbosacral spina bifida aperta    cervicothoracic spina bifida cystica
    thoracolumbosacral spina bifida aperta    neural tube defects    caudal regression syndrome    spina bifida

    1 disease from the University of Copenhagen DISEASES database for FUZ:
    Spina bifida

    Find genes that share disorders with FUZ           About GenesLikeMe


    Export disorders for FUZ gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FUZ gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with FUZ)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. PCP effector proteins inturned and fuzzy play nonredundant roles in the patterning but not convergent extension of mammalian neural tube. (PubMed id 21761479)1, 3 Heydeck W. and Liu A. (Dev. Dyn. 2011)
    2. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    3. Mutations in the planar cell polarity gene, Fuzzy, are associated with neural tube defects in humans. (PubMed id 21840926)1 Seo J.H....Torban E. (Hum. Mol. Genet. 2011)
    4. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)1 Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)
    5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (Biochem. Biophys. Res. Commun. 2006)
    6. Ciliogenesis defects in embryos lacking inturned or fuzzy function are associated with failure of planar cell polarity and Hedgehog signaling. (PubMed id 16493421)1 Park T.J....Wallingford J.B. (Nat. Genet. 2006)
    7. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (Nature 2005)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 80199 HGNC: 26219 AceView: FLJ22688 Ensembl:ENSG00000010361 euGenes: HUgn80199
    ECgene: FUZ H-InvDB: FUZ

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FUZ Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FUZ gene:
    Search GeneIP for patents involving FUZ

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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