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Aliases for FUT9 Gene

Aliases for FUT9 Gene

  • Fucosyltransferase 9 (Alpha (1,3) Fucosyltransferase) 2 3
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Fucosyltransferase IX 3 4
  • FucT-IX 3 4
  • Fuc-TIX 3 4
  • Alpha-(1,3)-Fucosyltransferase 9 3
  • Fucosyltransferase 9 4
  • EC 2.4.1.65 63
  • EC 2.4.1.- 4
  • EC 2.4.1 63

External Ids for FUT9 Gene

Previous GeneCards Identifiers for FUT9 Gene

  • GC06P096332
  • GC06P096480
  • GC06P096509
  • GC06P096570
  • GC06P096463
  • GC06P093896

Summaries for FUT9 Gene

Entrez Gene Summary for FUT9 Gene

  • The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]

GeneCards Summary for FUT9 Gene

FUT9 (Fucosyltransferase 9 (Alpha (1,3) Fucosyltransferase)) is a Protein Coding gene. Diseases associated with FUT9 include malaria. Among its related pathways are Metabolism and Other types of O-glycan biosynthesis. GO annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT9 Gene

  • Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.

Gene Wiki entry for FUT9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT9 Gene

Genomics for FUT9 Gene

Regulatory Elements for FUT9 Gene

Genomic Location for FUT9 Gene

Start:
96,015,969 bp from pter
End:
96,215,612 bp from pter
Size:
199,644 bases
Orientation:
Plus strand

Genomic View for FUT9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT9 Gene

Proteins for FUT9 Gene

  • Protein details for FUT9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y231-FUT9_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 9
    Protein Accession:
    Q9Y231
    Secondary Accessions:
    • Q5T0W4

    Protein attributes for FUT9 Gene

    Size:
    359 amino acids
    Molecular mass:
    42071 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT9 Gene

Proteomics data for FUT9 Gene at MOPED

Post-translational modifications for FUT9 Gene

  • Glycosylation at Asn62, Asn101, and Asn153
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT9 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FUT9 Gene

Gene Families for FUT9 Gene

HGNC:
  • FUT :Fucosyltransferases

Protein Domains for FUT9 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y231

UniProtKB/Swiss-Prot:

FUT9_HUMAN :
  • Q9Y231
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT9: view

Function for FUT9 Gene

Molecular function for FUT9 Gene

GENATLAS Biochemistry: fucosyltransferase 9,alpha (1.3) fucosyltransferase,abundantly expressed in brain and stomach,also detected in spleen and peripheral blood leukocytes,mouse Fuc-TIX ortholog,catalyzing the last step of Lewis X synthesis
UniProtKB/Swiss-Prot Function: Transfers a fucose to lacto-N-neotetraose but not to either alpha2,3-sialyl lacto-N-neotetraose or lacto-N-tetraose. Can catalyze the last step in the biosynthesis of Lewis antigen, the addition of a fucose to precursor polysaccharides.

Enzyme Numbers (IUBMB) for FUT9 Gene

Gene Ontology (GO) - Molecular Function for FUT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 10386598
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT9: view

Phenotypes for FUT9 Gene

genes like me logo Genes that share phenotypes with FUT9: view

Animal Models for FUT9 Gene

MGI Knock Outs for FUT9:

miRNA for FUT9 Gene

miRTarBase miRNAs that target FUT9

No data available for Transcription Factor Targeting and HOMER Transcription for FUT9 Gene

Localization for FUT9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT9 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT9 Gene COMPARTMENTS Subcellular localization image for FUT9 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FUT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT9: view

Pathways for FUT9 Gene

genes like me logo Genes that share pathways with FUT9: view

UniProtKB/Swiss-Prot Q9Y231-FUT9_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for FUT9 Gene

Gene Ontology (GO) - Biological Process for FUT9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 10386598
GO:0006486 protein glycosylation TAS 11698403
GO:0007399 nervous system development IEA --
GO:0036065 fucosylation TAS 10386598
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT9: view

Compounds for FUT9 Gene

(3) HMDB Compounds for FUT9 Gene

Compound Synonyms Cas Number PubMed IDs
GDP-L-fucose
  • GDP-beta-L-fucose
15839-70-0
Guanosine diphosphate
  • 5'-GDP
146-91-8
Neolactotetraose
  • Lacto-N-neo-tetraose
13007-32-4

(1) Novoseek inferred chemical compound relationships for FUT9 Gene

Compound -log(P) Hits PubMed IDs
polylactosamine 79.7 2
genes like me logo Genes that share compounds with FUT9: view

Transcripts for FUT9 Gene

mRNA/cDNA for FUT9 Gene

(10) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(4) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT9 Gene

Fucosyltransferase 9 (alpha (1,3) fucosyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5
SP1: - -
SP2:

Relevant External Links for FUT9 Gene

GeneLoc Exon Structure for
FUT9
ECgene alternative splicing isoforms for
FUT9

Expression for FUT9 Gene

mRNA expression in normal human tissues for FUT9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUT9 Gene

This gene is overexpressed in Brain - Cerebellum (8.0), Brain - Cerebellar Hemisphere (6.5), Brain - Cortex (4.5), and Brain - Frontal Cortex (BA9) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FUT9 Gene

SOURCE GeneReport for Unigene cluster for FUT9 Gene Hs.49117

mRNA Expression by UniProt/SwissProt for FUT9 Gene

Q9Y231-FUT9_HUMAN
Tissue specificity: Strongly expressed in forebrain and stomach, lower expression in spleen and peripheral blood leukocytes, and no expression in small intestine, colon, liver, lung, kidney, adrenal cortex or uterus.
genes like me logo Genes that share expressions with FUT9: view

Orthologs for FUT9 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT9 35
  • 99.35 (n)
  • 100 (a)
FUT9 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUT9 35
  • 93.31 (n)
  • 97.21 (a)
FUT9 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUT9 35
  • 94.71 (n)
  • 99.44 (a)
FUT9 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fut9 35
  • 91.46 (n)
  • 99.44 (a)
Fut9 16
Fut9 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUT9 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUT9 36
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut9 35
  • 91.27 (n)
  • 98.61 (a)
chicken
(Gallus gallus)
Aves CFUC-TIX 36
  • 84 (a)
OneToOne
FUT9 35
  • 83.01 (n)
  • 87.99 (a)
lizard
(Anolis carolinensis)
Reptilia FUT9 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fut9 35
  • 75.77 (n)
  • 82.45 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
fut9a 35
  • 62.11 (n)
  • 59.83 (a)
fut9a 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta FucTA 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea fut-1 36
  • 19 (a)
OneToMany
fut-3 36
  • 20 (a)
OneToMany
fut-4 36
  • 23 (a)
OneToMany
fut-5 36
  • 23 (a)
OneToMany
fut-6 36
  • 23 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 27 (a)
OneToMany
-- 36
  • 36 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
Species with no ortholog for FUT9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUT9 Gene

ENSEMBL:
Gene Tree for FUT9 (if available)
TreeFam:
Gene Tree for FUT9 (if available)

Paralogs for FUT9 Gene

Paralogs for FUT9 Gene

Selected SIMAP similar genes for FUT9 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FUT9: view

Variants for FUT9 Gene

Sequence variations from dbSNP and Humsavar for FUT9 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs716192 -- 96,063,813(-) TGGTG(C/T)GCAGG intron-variant
rs746810 -- 96,042,213(-) TGATG(A/G)TGCCC intron-variant
rs753501 -- 96,041,811(+) CCTCT(C/T)GTTAC intron-variant
rs753502 -- 96,041,816(+) TGTTA(C/T)GGCCT intron-variant
rs1318073 -- 96,056,091(+) TGAGT(C/T)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUT9 Gene

Variant ID Type Subtype PubMed ID
esv2422431 CNV Duplication 17116639
nsv830738 CNV Loss 17160897
esv2732455 CNV Deletion 23290073
nsv349387 CNV Loss 16902084
esv2732456 CNV Deletion 23290073
nsv349975 CNV Loss 16902084
nsv823781 CNV Gain 20364138
nsv823782 CNV Gain 20364138
esv271471 CNV Insertion 20981092
esv273075 CNV Insertion 20981092
esv1667871 CNV Insertion 17803354
esv2669302 CNV Deletion 23128226
nsv528247 CNV Gain 19592680
nsv886422 CNV Loss 21882294
nsv886423 CNV Loss 21882294
esv2732457 CNV Deletion 23290073
esv2675747 CNV Deletion 23128226
esv2732458 CNV Deletion 23290073
esv1046648 CNV Insertion 17803354

Relevant External Links for FUT9 Gene

HapMap Linkage Disequilibrium report
FUT9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT9 Gene

Disorders for FUT9 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for FUT9 Gene including...

Search for FUT9 Gene in MalaCards »

Relevant External Links for FUT9

Genetic Association Database (GAD)
FUT9
Human Genome Epidemiology (HuGE) Navigator
FUT9
genes like me logo Genes that share disorders with FUT9: view

No data available for UniProtKB/Swiss-Prot for FUT9 Gene

Publications for FUT9 Gene

  1. Alpha-1,3-fucosyltransferase IX (Fuc-TIX) is very highly conserved between human and mouse; molecular cloning, characterization and tissue distribution of human Fuc-TIX. (PMID: 10386598) Kaneko M. … Narimatsu H. (FEBS Lett. 1999) 2 3 4 23
  2. Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. (PMID: 10622713) Nishihara S. … Narimatsu H. (FEBS Lett. 1999) 3 23
  3. Human fucosyltransferase IX: specificity towards N-linked glycoproteins and relevance of the cytoplasmic domain in intra-Golgi localization. (PMID: 18395013) Brito C. … Costa J. (Biochimie 2008) 3 23
  4. CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV. (PMID: 11278338) Nakayama F. … Narimatsu H. (J. Biol. Chem. 2001) 3 23
  5. [Regulation by ovarian hormones of alpha 1,3-fucosyltransferase gene (FUT9) expression in human endometrium]. (PMID: 12417923) Li H. … Yan B. (Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 2002) 3 23

Products for FUT9 Gene

Sources for FUT9 Gene

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