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FUT8 Gene

protein-coding   GIFtS: 66
GCID: GC14P065877

Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase)

  See FUT8-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase)1 2     alpha-(1,6)-fucosyltransferase2
Glycoprotein 6-Alpha-L-Fucosyltransferase2 3     alpha1-6FucT2
GDP-Fucose--Glycoprotein Fucosyltransferase2 3     Alpha1-6FucT3
GDP-L-Fuc:N-Acetyl-Beta-D-Glucosaminide Alpha1,6-Fucosyltransferase2 3     Fucosyltransferase 83
EC 2.4.1.683 8     

External Ids:    HGNC: 40191   Entrez Gene: 25302   Ensembl: ENSG000000331707   OMIM: 6025895   UniProtKB: Q9BYC53   

Export aliases for FUT8 gene to outside databases

Previous GC identifers: GC14P063206 GC14P059672 GC14P063867 GC14P064947 GC14P046046


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FUT8 Gene:
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the
transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other
fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene
may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, May 2011)

GeneCards Summary for FUT8 Gene:
FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) is a protein-coding gene. Diseases associated with FUT8 include pancreatic acinar cell adenocarcinoma, and leukocyte adhesion deficiency. GO annotations related to this gene include SH3 domain binding and glycoprotein 6-alpha-L-fucosyltransferase activity.

UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide
chains in N-glycans

Gene Wiki entry for FUT8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FUT8 gene promoter:
         E2F-3a   E2F-4   Egr-2   E2F-5   E2F   E2F-1   POU3F1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FUT8 promoter sequence
   Search Chromatin IP Primers for FUT8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q24.3

FUT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065877:  view genomic region     (about GC identifiers)

Start:
65,877,310 bp from pter      End:
66,210,839 bp from pter
Size:
333,530 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for FUT8

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5 (See protein sequence)
Recommended Name: Alpha-(1,6)-fucosyltransferase  
Size: 575 amino acids; 66516 Da
1 PDB 3D structure from and Proteopedia for FUT8:
2DE0 (3D)    
Secondary accessions: B4DFS7 G3V5N0 O00235 Q8IUA5 Q9BYC6 Q9P2U5 Q9P2U6
Alternative splicing: 4 isoforms:  Q9BYC5-1   Q9BYC5-2   Q9BYC5-3   Q9BYC5-4   (Seems to be only expressed in retina, inactive as a fucosyltransferase)

Explore the universe of human proteins at neXtProt for FUT8: NX_Q9BYC5

Explore proteomics data for FUT8 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr564
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FUT8 (Q9BYC5) (see all 17)
     KAKEQIE  GGQNAHN  TGHWSGE  ETCTDRSG 


    See FUT8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_004471.4  NP_835368.1  NP_835369.1  

    ENSEMBL proteins: 
     ENSP00000353910   ENSP00000378087   ENSP00000452597   ENSP00000345865   ENSP00000452433  
     ENSP00000451689   ENSP00000451577   ENSP00000351057   ENSP00000452105   ENSP00000452309  
     ENSP00000452147   ENSP00000378086   ENSP00000396770  
    Reactome Protein details: Q9BYC5

    FUT8 Human Recombinant Protein Products:

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    Novus Biologicals FUT8 Proteins
    Novus Biologicals FUT8 Lysates
    Sino Biological Recombinant Protein for FUT8
    Sino Biological Cell Lysate for FUT8
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    Cloud-Clone Corp. Proteins for FUT8

     
    Search eBioscience for Proteins for FUT8 

    FUT8 Antibody Products:

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    Cloud-Clone Corp. ELISAs for FUT8
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    Search eBioscience for ELISAs for FUT8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FUT: Fucosyltransferases

    3 InterPro protein domains:
     IPR015827 Alpha1_6FUT_euk
     IPR001452 SH3_domain
     IPR027350 GT23_dom

    Graphical View of Domain Structure for InterPro Entry Q9BYC5

    ProtoNet protein and cluster: Q9BYC5

    UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
    Similarity: Belongs to the glycosyltransferase 23 family
    Similarity: Contains 1 GT23 domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with FUT8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT8_HUMAN, Q9BYC5
    Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide
    chains in N-glycans
    Catalytic activity: GDP-beta-L-fucose +
    N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine
    = GDP +
    N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine

         Genatlas biochemistry entry for FUT8:
    fucosyltransferase,alpha (1,6),8,involved in the biosynthesis of asparagine-linked glycoprotein oligosaccharides

         Enzyme Number (IUBMB): EC 2.4.1.681 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008424glycoprotein 6-alpha-L-fucosyltransferase activity TAS11698403
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0017124SH3 domain binding IEA--
    GO:0046921alpha-(1->6)-fucosyltransferase activity ----
         
    Find genes that share ontologies with FUT8           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fut8):
     growth/size/body  mortality/aging  respiratory system 

    Find genes that share phenotypes with FUT8           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fut8tm1Nta for FUT8

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FUT8
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FUT8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FUT8
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FUT8

    miRNA
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    miRTarBase miRNAs that target FUT8:
    hsa-mir-26b-5p (MIRT029006)

    Block miRNA regulation of human, mouse, rat FUT8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FUT8 (see all 44):
    hsa-miR-194* hsa-miR-323-3p hsa-miR-607 hsa-miR-342-3p hsa-miR-449a hsa-miR-3171 hsa-miR-570 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidFUT8 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FUT8
    Predesigned siRNA for gene silencing in human, mouse, rat FUT8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FUT8

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): FUT8 (NM_178155)
    Sino Biological Human cDNA Clone for FUT8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUT8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT8

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for FUT8 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FUT8_HUMAN, Q9BYC5: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity).
    Note=Membrane-bound form in trans cisternae of Golgi (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endoplasmic reticulum2
    cytosol1
    extracellular1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus NAS11698403
    GO:0016021integral component of membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with FUT8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FUT8 About    
    See pathways by source

    SuperPathContained pathways About
    1Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Asparagine N-linked glycosylation0.49
    Metabolism of proteins0.30
    N-Glycan biosynthesis0.49
    N-glycan antennae elongation in the medial/trans-Golgi0.00
    Post-translational protein modification0.43
    Reactions specific to the complex N-glycan synthesis pathway0.00
    Transport to the Golgi and subsequent modification0.40
    2Keratan sulfate/keratin metabolism
    Glycosaminoglycan biosynthesis - keratan sulfate0.43
    3Metabolism
    Metabolic pathways0.38
    4Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with FUT8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for FUT8
        Reactions specific to the complex N-glycan synthesis pathway


    4 Kegg Pathways  (Kegg details for FUT8):
        N-Glycan biosynthesis
    Glycosaminoglycan biosynthesis - keratan sulfate
    Metabolic pathways
    Transcriptional misregulation in cancer

    UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Array including FUT8: 

              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FUT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for FUT8 (Q9BYC53 ENSP000003539104) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IPMKQ8NFU53I2D: score=4 
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    B4GALT3ENSP000003209654STRING: ENSP00000320965
    MGAT2ENSP000003074234STRING: ENSP00000307423
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development NAS11698403
    GO:0006487protein N-linked glycosylation TAS9133635
    GO:0006491N-glycan processing TAS11698403
    GO:0007179transforming growth factor beta receptor signaling pathway IEA--
    GO:0007229integrin-mediated signaling pathway IEA--

    Find genes that share ontologies with FUT8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FUT8

    1 HMDB Compound for FUT8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    3 Novoseek inferred chemical compound relationships for FUT8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp fucose 84.7 2 18047682 (1), 9378548 (1)
    n-acetylglucosamine 70.4 3 19302290 (1), 18854874 (1), 17172260 (1)
    polysaccharide 38.5 1 18854874 (1)



    Find genes that share compounds with FUT8           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FUT8 gene (5 alternative transcripts): 
    NM_004480.4  NM_178155.2  NM_178156.2  NM_178154.1  NM_178157.1  

    Unigene Cluster for FUT8:

    Fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
    Hs.597649  [show with all ESTs]
    Unigene Representative Sequence: NM_178155
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360689(uc001xin.3 uc001xio.3 uc010tsp.2 uc001xir.4 uc001xip.3 uc001xiq.3 uc021ruy.1)
    ENST00000394586 ENST00000556518 ENST00000342677 ENST00000557164 ENST00000549235
    ENST00000555559 ENST00000553924 ENST00000358307 ENST00000557338 ENST00000554610
    ENST00000556292 ENST00000554667 ENST00000557536 ENST00000554765 ENST00000394585
    ENST00000417683
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    hsa-miR-194* hsa-miR-323-3p hsa-miR-607 hsa-miR-342-3p hsa-miR-449a hsa-miR-3171 hsa-miR-570 hsa-miR-186
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    Primer
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      QuantiFast Probe-based Assays in human, mouse, rat FUT8

    Additional mRNA sequence: 

    AF052088.1 AJ514324.1 AJ514325.1 AJ536053.1 AJ536054.1 AJ536055.1 AJ536056.1 AJ539535.1 
    AJ539536.1 AK292413.1 AK294242.1 BC025385.2 BC093889.1 BC101816.1 BC142958.1 D89289.1 
    NR_038167.1 NR_038170.1 Y17976.1 Y17977.1 Y17978.1 Y17979.1 

    10 DOTS entries:

    DT.97788347  DT.413509  DT.100823249  DT.406701  DT.100740622  DT.120745099  DT.120745131  DT.100677066 
    DT.100823253  DT.40123556 

    Selected AceView cDNA sequences (see all 235):

    AW086498 F05884 BP354921 CR617923 CB105802 CB105891 Z42069 BX161387 
    BX952151 CB159507 CB105886 BX456265 BQ653329 F01603 BQ423860 BM717378 
    CB105800 NM_004480 NM_178156 CB105602 AI142378 BQ962258 CB105817 Z44482 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FUT8 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:              -     -     -           -     -                                                     -                                                   
    SP2:                                      -     -     -     -     -     -     -                                                                           
    SP3:              -     -     -     -     -     -                                                                                                         
    SP4:              -     -     -                 -                                                                                                         
    SP5:                                            -                                                                                                         


    ECgene alternative splicing isoforms for FUT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FUT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAAATTCT
    FUT8 Expression
    About this image


    FUT8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    FUT8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FUT8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.597649
        Pathway & Disease-focused RT2 Profiler PCR Array including FUT8: 
              Glycosylation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FUT8 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fut81 , 5 fucosyltransferase 81, 5 91.77(n)1
    96.52(a)1
      12 (35.46 cM)5
    536181  NM_001252614.11  NP_001239543.11 
     772381045 
    chicken
    (Gallus gallus)
    Aves FUT81 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 83.48(n)
    93.91(a)
      423178  NM_001004766.1  NP_001004766.1 
    lizard
    (Anolis carolinensis)
    Reptilia FUT86
    fucosyltransferase 8 (alpha (1,6) fucosyltransfera...
    93(a)
    1 ↔ 1
    1(44582176-44655370)
    African clawed frog
    (Xenopus laevis)
    Amphibia fut8-A2 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 79.58(n)    AJ514872.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.53032 Transcribed sequence with weak similarity to protein more 76.07(n)    57057941 
    fruit fly
    (Drosophila melanogaster)
    Insecta FucT61 , 3 protein amino acid glycosylation
    glycoprotein
    more3
    alpha1,6-fucosyltransferase1
    46(a)3
    52.7(n)1
    49.91(a)1
      10D63
    321221  NM_132512.41  NP_572740.11 
    worm
    (Caenorhabditis elegans)
    Secernentea fut-81 fut-8 50.61(n)
    40.43(a)
      178985  NM_072154.5  NP_504555.2 


    ENSEMBL Gene Tree for FUT8 (if available)
    TreeFam Gene Tree for FUT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FUT8 (see all 6166)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669111261,2
    C--46279920(+) AAAAT-/ACAC  
      ACACAC
    ACACA
    5 -- int10--------
    rs1878775261,2
    --65875312(+) TTAATA/GAGGAA 4 -- us2k10--------
    rs1921685081,2
    --65875348(+) AATCAA/GTAGTG 4 -- us2k10--------
    rs1837397321,2
    --65875531(+) TTTAAC/GGAGCT 4 -- us2k10--------
    rs1413264491,2
    --65875836(+) CCCAGA/GTGGGT 4 -- us2k10--------
    rs1156536041,2
    F--65875963(+) AAAACA/TACGAG 4 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1172297471,2
    F--65875975(+) ACAATT/GAACAA 4 -- us2k11Minor allele frequency- G:0.01NA 120
    rs171026551,2
    C,F--65876031(+) GTAGAG/CATAGA 4 -- us2k1 tfbs34Minor allele frequency- C:0.03NA WA 260
    rs756361611,2
    C,F--65876120(+) CTCCCC/GACCGT 4 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1451087951,2
    --65876292(+) TTCACA/TACTTA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for FUT8 (65877310 - 66127310 bp, first 250kb of FUT8)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FUT8 (see all 20):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748794CNV Deletion23290073
    esv2748779CNV Deletion23290073
    esv2748793CNV Deletion23290073
    esv2748798CNV Deletion23290073
    esv2664690CNV Deletion23128226
    esv2748795CNV Deletion23290073
    esv1385928CNV Deletion17803354
    esv2413773CNV Deletion18987734
    esv2659861CNV Deletion23128226
    esv2677649CNV Deletion23128226

    Human Gene Mutation Database (HGMD): FUT8
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FUT8
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602589    OMIM disorders: --

    2 diseases for FUT8:    
    About MalaCards
    pancreatic acinar cell adenocarcinoma    leukocyte adhesion deficiency

    1 disease from the University of Copenhagen DISEASES database for FUT8:
    Pancreatic acinar cell adenocarcinoma

    Find genes that share disorders with FUT8           About GenesLikeMe

    4 Novoseek inferred disease relationships for FUT8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 25.7 3 9378548 (1), 18754874 (1)
    gastric cancer 19 2 10580126 (1)
    metastasis 12.2 7 10232614 (1), 14568171 (1)
    tumors 0.976 5 10232614 (1), 14568171 (1), 9378548 (1), 10580126 (1)

    Genetic Association Database (GAD): FUT8
    Human Genome Epidemiology (HuGE) Navigator: FUT8 (3 documents)

    Export disorders for FUT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FUT8 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with FUT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. (PubMed id 17172260)1, 2, 9 Ihara H....Taniguchi N. (Glycobiology 2007)
    2. Genomic structure and promoter analysis of the human alpha1,6- fucosyltransferase gene (FUT8). (PubMed id 10814706)1, 2, 9 Yamaguchi Y.... Taniguchi N. (Glycobiology 2000)
    3. Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1I+ as a master regulator of plasma protein fucosylation. (PubMed id 21203500)1, 4 Lauc G....Rudan I. (PLoS Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Activity and tissue distribution of splice variants of alpha6- fucosyltransferase in human embryogenesis. (PubMed id 14514715)1, 2 Martinez-Duncker I.... Mollicone R. (Glycobiology 2004)
    6. A sequence motif involved in the donor substrate binding by alpha1,6- fucosyltransferase: the role of the conserved arginine residues. (PubMed id 10764839)1, 2 Takahashi T....Taniguchi N. (Glycobiology 2000)
    7. Evolution of fucosyltransferase genes in vertebrates. (PubMed id 9368041)1, 3 Costache M....Mollicone R. (J. Biol. Chem. 1997)
    8. Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D- glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells. (PubMed id 9133635)1, 2 Yanagidani S....Taniguchi N. (J. Biochem. 1997)
    9. The alpha1-6-fucosyltransferase gene and its biological significance. (PubMed id 10580126)1, 9 Miyoshi E....Taniguchi N. (Biochim. Biophys. Acta 1999)
    10. Reaction mechanism and substrate specificity for nucleotide sugar of mammalian alpha1,6-fucosyltransferase--a large-scale preparation and characterization of recombinant human FUT8. (PubMed id 16344263)1, 9 Ihara H....Taniguchi N. (Glycobiology 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2530 HGNC: 4019 AceView: FUT8 Ensembl:ENSG00000033170 euGenes: HUgn2530
    ECgene: FUT8 Kegg: 2530 H-InvDB: FUT8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FUT8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FUT8 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT8
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_605

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FUT8 gene:
    Search GeneIP for patents involving FUT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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