Aliases for FUT8 Gene
- Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase) 2 3
- GDP-L-Fuc:N-Acetyl-Beta-D-Glucosaminide Alpha1,6-Fucosyltransferase 3 4
- GDP-Fucose--Glycoprotein Fucosyltransferase 3 4
- Glycoprotein 6-Alpha-L-Fucosyltransferase 3 4
- Alpha1-6FucT 3 4
- EC 188.8.131.52 4 63
- Alpha-(1,6)-Fucosyltransferase 3
- Fucosyltransferase 8 4
External Ids for FUT8 Gene
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
GeneCards Summary for FUT8 Gene
FUT8 (Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase)) is a Protein Coding gene. Diseases associated with FUT8 include pancreatic acinar cell adenocarcinoma and leukocyte adhesion deficiency. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include SH3 domain binding and glycoprotein 6-alpha-L-fucosyltransferase activity.
UniProtKB/Swiss-Prot for FUT8 Gene
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.