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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT8 Gene

protein-coding   GIFtS: 64
GCID: GC14P065877

fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
 Explore 16 diseases affiliated with
FUT8 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FUT8    

Aliases
for FUT8 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase)1 2     Alpha-(1,6)-Fucosyltransferase1
Glycoprotein 6-Alpha-L-Fucosyltransferase2 3     Alpha1-6FucT3
GDP-Fucose--Glycoprotein Fucosyltransferase2 3     Alpha1-6FucT3
GDP-L-Fuc:N-Acetyl-Beta-D-Glucosaminide Alpha1,6-Fucosyltransferase2 3     Fucosyltransferase 83
EC 2.4.1.683 8     

External Ids:    HGNC: 40191   Entrez Gene: 25302   Ensembl: ENSG000000331707   OMIM: 6025895   UniProtKB: Q9BYC53   
ORGUL members:         
NONCODE:n410733 n410732    

Export aliases for FUT8 gene to outside databases

Previous GC identifers: GC14P063206 GC14P059672 GC14P063867 GC14P064947 GC14P046046


Summaries
for FUT8 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FUT8:
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the
transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other
fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may
contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing
results in multiple transcript variants. (provided by RefSeq, May 2011)

UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains
in N-glycans

Gene Wiki entry for FUT8


Genomic Views
for FUT8 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT8 gene promoter:
         E2F-3a   E2F-4   Egr-2   E2F-5   E2F   E2F-1   POU3F1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FUT8 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q24.3

FUT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065877:  view genomic region     (about GC identifiers)

Start:
 65,877,310 bp from pter      End:
 66,210,839 bp from pter
Size:
 333,530 bases      Orientation:
 plus strand
ORGUL member locations:
Legend (see complete legend)

  • n410732
  • n410733
65877309 66044074 66210839 chr14

Proteins
for FUT8 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5 (See protein sequence)
Recommended Name: Alpha-(1,6)-fucosyltransferase  
Size: 575 amino acids; 66516 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity).
Note=Membrane-bound form in trans cisternae of Golgi (By similarity)
1 PDB 3D structure from and Proteopedia for FUT8:
2DE0 (3D)    
Secondary accessions: O00235 Q9BYC6 Q9P2U5 Q9P2U6
Alternative splicing: 2 isoforms:  Q9BYC5-1   Q9BYC5-2   

Explore the universe of human proteins at neXtProt for FUT8: NX_Q9BYC5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYC5

    • 4/17 DME Specific Peptides for FUT8 (Q9BYC5) (see all 17)
     KAKEQIE  GGQNAHN  TGHWSGE  ETCTDRSG 

    FUT8 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_004471.4  NP_835368.1  NP_835369.1  

    ENSEMBL proteins: 
     ENSP00000353910   ENSP00000378087   ENSP00000452597   ENSP00000345865   ENSP00000452433  
     ENSP00000451689   ENSP00000451577   ENSP00000351057   ENSP00000452105   ENSP00000452309  
     ENSP00000452147   ENSP00000378086   ENSP00000396770  
    Reactome Protein details: Q9BYC5
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for FUT8 (Fucosyltransferase 8/FUT8)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins (see all 2): FUT8
    OriGene Protein Over-expression Lysate (see all 3): FUT8
    OriGene Custom Protein Services for FUT8 
    GenScript Custom Purified and Recombinant Proteins Services for FUT8
    Novus Biologicals FUT8 Proteins
    Novus Biologicals FUT8 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FUT8

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus NAS11698403
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--


    FUT8 for ontologies           About GeneDecksing



    FUT8 Antibody Products: 
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    Assay Products for FUT8: 
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    Uscn ELISAs and CLIAs for FUT8

    Protein Domains /
    Families
    for FUT8 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FUT8 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR015827 Alpha1_6FUT_euk
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q9BYC5

    ProtoNet protein and cluster: Q9BYC5

    UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
    Similarity: Belongs to the glycosyltransferase 23 family
    Similarity: Contains 1 GT23 domain
    Similarity: Contains 1 SH3 domain


    Function
    for FUT8 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
    Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains
    in N-glycans
    Catalytic activity: GDP-beta-L-fucose +
    N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine
    = GDP +
    N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine

         Genatlas biochemistry entry for FUT8:
    fucosyltransferase,alpha (1,6),8,involved in the biosynthesis of asparagine-linked glycoprotein oligosaccharides

    Enzyme Number (IUBMB): EC 2.4.1.681 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FUT8
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate FUT8 (see all 44):
    hsa-miR-194* hsa-miR-323-3p hsa-miR-607 hsa-miR-342-3p hsa-miR-449a hsa-miR-3171 hsa-miR-570 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: FUT8 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUT8 (see all 7)
    OriGene shRNA RFP: FUT8
    OriGene siRNA: FUT8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUT8

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for FUT8

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUT8 (see all 6)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): FUT8 (NM_178155)
    Sino Biological Human cDNA Clone for FUT8
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT8 

    Cell Line
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    Search LifeMap BioReagents cell lines for FUT8

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT8

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008424glycoprotein 6-alpha-L-fucosyltransferase activity TAS11698403
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0017124SH3 domain binding IEA--
    GO:0046921alpha-(1->6)-fucosyltransferase activity ----


    FUT8 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fut8tm1Nta for FUT8
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fut8):
     growth/size  mortality/aging  respiratory system 

    FUT8 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FUT8 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Post-translational protein modification0.44
    		N-Glycan biosynthesis0.52
    		Metabolism of proteins0.15
    2N-glycan antennae elongation in the medial/trans-Golgi
    		N-glycan antennae elongation in the medial/trans-Golgi1.00
    		Transport to the Golgi and subsequent modification0.56
    3Reactions specific to the complex N-glycan synthesis pathway
    		Reactions specific to the complex N-glycan synthesis pathway1.00
    4Keratan sulfate biosynthesis
    		Glycosaminoglycan biosynthesis - keratan sulfate0.45
    5Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for FUT8 (see all 6)
        N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification
    Reactions specific to the complex N-glycan synthesis pathway
    Asparagine N-linked glycosylation
    Metabolism of proteins


    3         Kegg Pathways  (Kegg details for FUT8):
        N-Glycan biosynthesis
    Glycosaminoglycan biosynthesis - keratan sulfate
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
    Pathway: Protein modification; protein glycosylation


    FUT8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for FUT8 (Q9BYC53 ENSP000003539104) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    IPMKQ8NFU53I2D: score=4 
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    B4GALT3ENSP000003209654STRING: ENSP00000320965
    MGAT2ENSP000003074234STRING: ENSP00000307423
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development NAS11698403
    GO:0006487protein N-linked glycosylation TAS9133635
    GO:0006491N-glycan processing TAS11698403
    GO:0007179transforming growth factor beta receptor signaling pathway IEA--
    GO:0007229integrin-mediated signaling pathway IEA--


    FUT8 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FUT8 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT8

    1 HMDB Compound for FUT8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    3 Novoseek chemical compound relationships for FUT8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp fucose 84.7 2 18047682 (1), 9378548 (1)
    n-acetylglucosamine 70.4 3 19302290 (1), 18854874 (1), 17172260 (1)
    polysaccharide 38.5 1 18854874 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT8 

    Transcripts
    for FUT8 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FUT8 gene (5 alternative transcripts): 
    NM_004480.4  NM_178155.2  NM_178156.2  NM_178154.1  NM_178157.1  

    Unigene Cluster for FUT8:

    Fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
    Hs.597649  [show with all ESTs]
    Unigene Representative Sequence: NM_178155
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360689(uc001xin.3 uc001xio.3 uc010tsp.2 uc001xir.4 uc001xip.3 uc001xiq.3 uc021ruy.1)
    ENST00000394586 ENST00000556518 ENST00000342677 ENST00000557164 ENST00000549235
    ENST00000555559 ENST00000553924 ENST00000358307 ENST00000557338 ENST00000554610
    ENST00000556292 ENST00000554667 ENST00000557536 ENST00000554765 ENST00000394585
    ENST00000417683

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FUT8
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate FUT8 (see all 44):
    hsa-miR-194* hsa-miR-323-3p hsa-miR-607 hsa-miR-342-3p hsa-miR-449a hsa-miR-3171 hsa-miR-570 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmid: FUT8 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF052088.1 AJ514324.1 AJ514325.1 AJ536053.1 AJ536054.1 AJ536055.1 AJ536056.1 AJ539535.1 
    AJ539536.1 AK292413.1 AK294242.1 BC025385.2 BC093889.1 BC101816.1 BC142958.1 D89289.1 
    NR_038167.1 NR_038170.1 Y17976.1 Y17977.1 Y17978.1 Y17979.1 

    9 DOTS entries:

    DT.97788347  DT.413509  DT.100823249  DT.406701  DT.120745099  DT.120745131  DT.100677066  DT.100823253 
    DT.40123556 

    24/235 AceView cDNA sequences (see all 235):

    AA897284 F05884 CB105873 AA886352 BQ423860 BQ653329 F01603 CB105800 
    CR617923 CB159507 BX952151 Z42069 AW086498 BI517671 BI964023 CB105618 
    CB105882 AW002060 AI147370 CB105802 CB105611 NM_178155 CB105608 NM_178157 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for FUT8 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:              -     -     -           -     -                                                     -                                                   
    SP2:                                      -     -     -     -     -     -     -                                                                           
    SP3:              -     -     -     -     -     -                                                                                                         
    SP4:              -     -     -                 -                                                                                                         
    SP5:                                            -                                                                                                         


    ECgene alternative splicing isoforms for FUT8

    Expression
    for FUT8 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AACAAATTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FUT8 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Definitive endoderm-like cells (A scalable, suspensi...)
    Extraembryonic endoderm-like cells (Generation of extrae...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FUT8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT8

    SOURCE GeneReport for Unigene cluster: Hs.597649
        SABiosciences Expression via Pathway-Focused PCR Array including FUT8: 
              Glycosylation in human mouse rat

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    Orthologs
    for FUT8 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FUT8 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Fut81 , 5 fucosyltransferase 81, 5 91.77(n)1
    96.52(a)1    		   12 (35.46 cM)5
    536181  NM_001252614.11  NP_001239543.11 
     772381045 
    chicken
    (Gallus gallus)    		 Aves FUT81 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 83.48(n)
    93.91(a)    		   423178  NM_001004766.1  NP_001004766.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FUT86
    		 --
    		 92(a)
    		 1 ↔ 1
    		 1(44582366-44651375)
    African clawed frog
    (Xenopus laevis)    		 Amphibia fut8-A2 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 79.58(n)    AJ514872.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.53032 Transcribed sequence with weak similarity to protein more 76.07(n)    57057941 
    fruit fly
    (Drosophila melanogaster)    		 Insecta FucT61 , 3 protein amino acid glycosylation
    glycoprotein more3
    alpha1,6-fucosyltransferase1    		 46(a)3
    52.83(n)1
    50.09(a)1    		   10D63
    321221  NM_132512.31  NP_572740.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea fut-81 Protein FUT-8 50.88(n)
    40.35(a)    		   178985  NM_072154.4  NP_504555.2 


    ENSEMBL Gene Tree for FUT8 (if available)
    TreeFam Gene Tree for FUT8 (if available) 

    Paralogs
    for FUT8 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for FUT8 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5368 NCBI SNPs in FUT8 are shown (see all 5368)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs347464441,2
    		C,--46364850(+) AGATA-/ACACAA 1 -- int11Minor allele frequency- A:0.00NA 2
    rs1878775261,2
    		--65875312(+) TTAATA/GAGGAA 4 -- us2k10--------
    rs1921685081,2
    		--65875348(+) AATCAA/GTAGTG 4 -- us2k10--------
    rs1837397321,2
    		--65875531(+) TTTAAC/GGAGCT 4 -- us2k10--------
    rs1413264491,2
    		--65875836(+) CCCAGA/GTGGGT 4 -- us2k10--------
    rs1156536041,2
    		F,--65875963(+) AAAACA/TACGAG 4 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1172297471,2
    		--65875975(+) ACAATT/GAACAA 4 -- us2k11Minor allele frequency- G:0.01NA 120
    rs171026551,2
    		C,--65876031(+) GTAGAG/CATAGA 4 -- us2k1 tfbs34Minor allele frequency- C:0.03NA WA 260
    rs756361611,2
    		C,F,--65876120(+) CTCCCC/GACCGT 4 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1451087951,2
    		--65876292(+) TTCACA/TACTTA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for FUT8 (65877310 - 66127310 bp, first 250kb of FUT8)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for FUT8
         2 CNVs: 49400 87252
         1 Inversion: 37161
    Human Gene Mutation Database (HGMD): FUT8

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    Disorders / Diseases
    for FUT8 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FUT8 for disorders           About GeneDecksing

    OMIM gene information: 602589    OMIM disorders: --

    16 diseases for FUT8:    About MalaCards
    recurrent respiratory papillomatosis    pancreatic acinar cell adenocarcinoma    congenital disorder of glycosylation    papillary carcinoma
    multiple sclerosis    gastric cancer    emphysema    colon carcinoma
    hepatocellular carcinoma    lung cancer    adenocarcinoma    carcinoma
    pancreatitis    adenoma    immunodeficiency    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for FUT8:
    Pancreatic acinar cell adenocarcinoma

    4 Novoseek disease relationships for FUT8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 25.7 3 9378548 (1), 18754874 (1)
    gastric cancer 19 2 10580126 (1)
    metastasis 12.2 7 10232614 (1), 14568171 (1)
    tumors 0.976 5 10232614 (1), 14568171 (1), 9378548 (1), 10580126 (1)

    Human Genome Epidemiology (HuGE) Navigator: FUT8 (3 documents)

    Export disorders for FUT8 gene to outside databases

    Publications
    for FUT8 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT8 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with FUT8)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and promoter analysis of the human alpha1,6- fucosyltransferase gene (FUT8). (PubMed id 10814706)1, 2, 9 Yamaguchi Y.... Taniguchi N. (2000)
    2. A sequence motif involved in the donor substrate binding by alpha1,6- fucosyltransferase: the role of the conserved arginine residues. (PubMed id 10764839)1, 2 Takahashi T....Taniguchi N. (2000)
    3. Evolution of fucosyltransferase genes in vertebrates. (PubMed id 9368041)1, 3 Costache M....Mollicone R. (1997)
    4. Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D- glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells. (PubMed id 9133635)1, 2 Yanagidani S....Taniguchi N. (1997)
    5. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. (PubMed id 17172260)1, 9 Ihara H....Taniguchi N. (2007)
    6. The alpha1-6-fucosyltransferase gene and its biological significance. (PubMed id 10580126)1, 9 Miyoshi E....Taniguchi N. (1999)
    7. Reaction mechanism and substrate specificity for nucleotide sugar of mammalian alpha1,6-fucosyltransferase--a large-scale preparation and characterization of recombinant human FUT8. (PubMed id 16344263)1, 9 Ihara H....Taniguchi N. (2006)
    8. Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation. (PubMed id 14568171)1, 9 Ito Y....Miyoshi E. (2003)
    9. N-Glycan fucosylation of epidermal growth factor receptor modulates receptor activity and sensitivity to epidermal growth factor receptor tyrosine kinase inhibitor. (PubMed id 18754874)1, 9 Matsumoto K....Nishio K. (2008)
    10. Effects of inhibitor of Src kinases, SU6656, on differentiation of megakaryocytic progenitors and activity of alpha1,6-fucosyltransferase. (PubMed id 18854874)1, 9 Kaminska J....Bany-Laszewicz U. (2008)

    External Searches for FUT8 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FUT8 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2530 HGNC: 4019 AceView: FUT8 Ensembl:ENSG00000033170 euGenes: HUgn2530
    ECgene: FUT8 Kegg: 2530 H-InvDB: FUT8

    Other Databases showing FUT8 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FUT8 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FUT8 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT8
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_605

    Intellectual Property
    for FUT8 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FUT8 gene:
    Search GeneIP for patents involving FUT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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