Aliases for FUT8 Gene
- Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase) 2 3
- GDP-L-Fuc:N-Acetyl-Beta-D-Glucosaminide Alpha1,6-Fucosyltransferase 3 4
- GDP-Fucose--Glycoprotein Fucosyltransferase 3 4
- Glycoprotein 6-Alpha-L-Fucosyltransferase 3 4
- Alpha1-6FucT 3 4
- EC 188.8.131.52 4 63
- Alpha-(1,6)-Fucosyltransferase 3
- Fucosyltransferase 8 4
External Ids for FUT8 Gene
Previous GeneCards Identifiers for FUT8 Gene
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
GeneCards Summary for FUT8 Gene
FUT8 (Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase)) is a Protein Coding gene. Diseases associated with FUT8 include pancreatic acinar cell adenocarcinoma and leukocyte adhesion deficiency. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include SH3 domain binding and glycoprotein 6-alpha-L-fucosyltransferase activity.
UniProtKB/Swiss-Prot for FUT8 Gene
Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.