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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT8 Gene

protein-coding   GIFtS: 66
GCID: GC14P065877

Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3.2

Aliases
Fucosyltransferase 8 (Alpha (1,6) Fucosyltransferase)1 2     alpha-(1,6)-fucosyltransferase2
Glycoprotein 6-Alpha-L-Fucosyltransferase2 3     alpha1-6FucT2
GDP-Fucose--Glycoprotein Fucosyltransferase2 3     Alpha1-6FucT3
GDP-L-Fuc:N-Acetyl-Beta-D-Glucosaminide Alpha1,6-Fucosyltransferase2 3     Fucosyltransferase 83
EC 2.4.1.683 8     

External Ids:    HGNC: 40191   Entrez Gene: 25302   Ensembl: ENSG000000331707   OMIM: 6025895   UniProtKB: Q9BYC53   
ORGUL members:    fRNAdb10:FR327282      
NONCODE14:n410732 n410733      
RNAdb15:EVF31508    

Export aliases for FUT8 gene to outside databases

Previous GC identifers: GC14P063206 GC14P059672 GC14P063867 GC14P064947 GC14P046046


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FUT8 Gene:
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the
transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other
fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene
may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative
splicing results in multiple transcript variants. (provided by RefSeq, May 2011)

GeneCards Summary for FUT8 Gene: 
FUT8 (fucosyltransferase 8 (alpha (1,6) fucosyltransferase)) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with FUT8 include pancreatic acinar cell adenocarcinoma, and recurrent respiratory papillomatosis, and among its related super-pathways are WNT ligand biogenesis and trafficking and N-Glycan antennae elongation. GO annotations related to this gene include SH3 domain binding and glycoprotein 6-alpha-L-fucosyltransferase activity.

UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide
chains in N-glycans

Gene Wiki entry for FUT8 Gene

fRNAdb sequence ontology for FUT8:
nc_conserved_region - Non-coding region of sequence similarity by descent from a common ancestor.

View fRNAdb secondary structures for FUT8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT8 gene promoter:
         E2F-3a   E2F-4   Egr-2   E2F-5   E2F   E2F-1   POU3F1   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FUT8 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q23.3   HGNC cytogenetic band: 14q24.3

FUT8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT8 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P065877:  view genomic region     (about GC identifiers)

Start:
65,877,310 bp from pter      End:
66,210,839 bp from pter
Size:
333,530 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for FUT8

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5 (See protein sequence)
Recommended Name: Alpha-(1,6)-fucosyltransferase  
Size: 575 amino acids; 66516 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity).
Note=Membrane-bound form in trans cisternae of Golgi (By similarity)
1 PDB 3D structure from and Proteopedia for FUT8:
2DE0 (3D)    
Secondary accessions: B4DFS7 G3V5N0 O00235 Q9BYC6 Q9P2U5 Q9P2U6
Alternative splicing: 3 isoforms:  Q9BYC5-1   Q9BYC5-2   Q9BYC5-3   

Explore the universe of human proteins at neXtProt for FUT8: NX_Q9BYC5

Explore proteomics data for FUT8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BYC5

  • 4/17 DME Specific Peptides for FUT8 (Q9BYC5) (see all 17)
     KAKEQIE  GGQNAHN  TGHWSGE  ETCTDRSG 

    FUT8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FUT8 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_004471.4  NP_835368.1  NP_835369.1  

    ENSEMBL proteins: 
     ENSP00000353910   ENSP00000378087   ENSP00000452597   ENSP00000345865   ENSP00000452433  
     ENSP00000451689   ENSP00000451577   ENSP00000351057   ENSP00000452105   ENSP00000452309  
     ENSP00000452147   ENSP00000378086   ENSP00000396770  
    Reactome Protein details: Q9BYC5
    Human Recombinant Protein Products for FUT8: 
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    OriGene Purified Proteins for FUT8
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    GenScript Custom Purified and Recombinant Proteins Services for FUT8
    Novus Biologicals FUT8 Proteins
    Novus Biologicals FUT8 Lysates
    Sino Biological Recombinant Protein for FUT8
    Sino Biological Cell Lysate for FUT8 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FUT8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005794Golgi apparatus NAS11698403
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    FUT8 for ontologies           About GeneDecksing



    FUT8 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FUT: Fucosyltransferases

    3 InterPro protein domains:
     IPR015827 Alpha1_6FUT_euk
     IPR001452 SH3_domain
     IPR027350 GT23_dom

    Graphical View of Domain Structure for InterPro Entry Q9BYC5

    ProtoNet protein and cluster: Q9BYC5

    UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
    Similarity: Belongs to the glycosyltransferase 23 family
    Similarity: Contains 1 GT23 domain
    Similarity: Contains 1 SH3 domain


    FUT8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT8_HUMAN, Q9BYC5
    Function: Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide
    chains in N-glycans
    Catalytic activity: GDP-beta-L-fucose +
    N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl)asparagine
    = GDP +
    N(4)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-(N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6))-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-(alpha-L-fucosyl-(1->6))-N-acetyl-beta-D-glucosaminyl)asparagine

         Genatlas biochemistry entry for FUT8:
    fucosyltransferase,alpha (1,6),8,involved in the biosynthesis of asparagine-linked glycoprotein oligosaccharides

         Enzyme Number (IUBMB): EC 2.4.1.681 2

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008424glycoprotein 6-alpha-L-fucosyltransferase activity TAS11698403
    GO:0016757transferase activity, transferring glycosyl groups ----
    GO:0017124SH3 domain binding IEA--
    GO:0046921alpha-(1->6)-fucosyltransferase activity ----
         
    FUT8 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fut8):
     growth/size  mortality/aging  respiratory system 

    FUT8 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Fut8tm1Nta for FUT8

       inGenious Targeting Laboratory - Custom generated mouse model solutions for FUT8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FUT8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FUT8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FUT8 

    miRNA
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    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate FUT8 (see all 44):
    hsa-miR-194* hsa-miR-323-3p hsa-miR-607 hsa-miR-342-3p hsa-miR-449a hsa-miR-3171 hsa-miR-570 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidFUT8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of FUT8 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FUT8 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Asparagine N-linked glycosylation
    Asparagine N-linked glycosylation0.77
    N-Glycan biosynthesis0.52
    WNT ligand biogenesis and trafficking0.77
    Post-translational protein modification0.44
    Signaling by Wnt0.62
    Metabolism of proteins0.35
    2N-glycan antennae elongation in the medial/trans-Golgi
    N-glycan antennae elongation in the medial/trans-Golgi0.75
    Transport to the Golgi and subsequent modification0.56
    3Signaling by GPCR
    Signal Transduction0.55
    4Keratan sulfate biosynthesis
    Glycosaminoglycan biosynthesis - keratan sulfate0.43
    5Metabolism
    Metabolic pathways0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    5/9        Reactome Pathways for FUT8 (see all 9)
        Reactions specific to the complex N-glycan synthesis pathway
    Signaling by Wnt
    Asparagine N-linked glycosylation
    N-glycan antennae elongation in the medial/trans-Golgi
    Transport to the Golgi and subsequent modification


    4         Kegg Pathways  (Kegg details for FUT8):
        N-Glycan biosynthesis
    Glycosaminoglycan biosynthesis - keratan sulfate
    Metabolic pathways
    Transcriptional misregulation in cancer

    UniProtKB/Swiss-Prot: FUT8_HUMAN, Q9BYC5
    Pathway: Protein modification; protein glycosylation


    FUT8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/8 Interacting proteins for FUT8 (Q9BYC53 ENSP000003539104) via UniProtKB, MINT, STRING, and/or I2D (see all 8)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    IPMKQ8NFU53I2D: score=4 
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    B4GALT3ENSP000003209654STRING: ENSP00000320965
    MGAT2ENSP000003074234STRING: ENSP00000307423
    About this table

    Gene Ontology (GO): 5/15 biological process terms (GO ID links to tree view) (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001701in utero embryonic development NAS11698403
    GO:0006487protein N-linked glycosylation TAS9133635
    GO:0006491N-glycan processing TAS11698403
    GO:0007179transforming growth factor beta receptor signaling pathway IEA--
    GO:0007229integrin-mediated signaling pathway IEA--

    FUT8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT8

    1 HMDB Compound for FUT8    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    3 Novoseek inferred chemical compound relationships for FUT8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp fucose 84.7 2 18047682 (1), 9378548 (1)
    n-acetylglucosamine 70.4 3 19302290 (1), 18854874 (1), 17172260 (1)
    polysaccharide 38.5 1 18854874 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    1 fRNAdb Secondary structure:


    REFSEQ mRNAs for FUT8 gene (5 alternative transcripts): 
    NM_004480.4  NM_178155.2  NM_178156.2  NM_178154.1  NM_178157.1  

    Unigene Cluster for FUT8:

    Fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
    Hs.597649  [show with all ESTs]
    Unigene Representative Sequence: NM_178155
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000360689(uc001xin.3 uc001xio.3 uc010tsp.2 uc001xir.4 uc001xip.3 uc001xiq.3 uc021ruy.1)
    ENST00000394586 ENST00000556518 ENST00000342677 ENST00000557164 ENST00000549235
    ENST00000555559 ENST00000553924 ENST00000358307 ENST00000557338 ENST00000554610
    ENST00000556292 ENST00000554667 ENST00000557536 ENST00000554765 ENST00000394585
    ENST00000417683
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    Additional mRNA sequence: 

    AF052088.1 AJ514324.1 AJ514325.1 AJ536053.1 AJ536054.1 AJ536055.1 AJ536056.1 AJ539535.1 
    AJ539536.1 AK292413.1 AK294242.1 BC025385.2 BC093889.1 BC101816.1 BC142958.1 D89289.1 
    NR_038167.1 NR_038170.1 Y17976.1 Y17977.1 Y17978.1 Y17979.1 

    10 DOTS entries:

    DT.97788347  DT.413509  DT.100823249  DT.406701  DT.100740622  DT.120745099  DT.120745131  DT.100677066 
    DT.100823253  DT.40123556 

    24/235 AceView cDNA sequences (see all 235):

    BX456265 CB105882 AW387766 CB105873 CB105608 AW769655 D89289 BM717378 
    CB105809 CF994460 CB105802 CB105618 BI517671 BX952151 NM_178154 CB105891 
    CB159507 CB105886 AA897284 AI142378 CB105621 BI831206 AL079713 Z42069 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for FUT8 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b
    SP1:              -     -     -           -     -                                                     -                                                   
    SP2:                                      -     -     -     -     -     -     -                                                                           
    SP3:              -     -     -     -     -     -                                                                                                         
    SP4:              -     -     -                 -                                                                                                         
    SP5:                                            -                                                                                                         


    ECgene alternative splicing isoforms for FUT8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT8 expression in normal human tissues (normalized intensities)      FUT8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAAATTCT
    FUT8 Expression
    About this image


    FUT8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Umbilical Cord (Extraembryonic Tissues)
             cord blood   
     
     Blood (Extraembryonic Tissues)
             cord blood   
     
     Uncategorized (Uncategorized)
             PureStem Progenitor W10

    See FUT8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT8

    SOURCE GeneReport for Unigene cluster: Hs.597649
        SABiosciences Expression via Pathway-Focused PCR Array including FUT8: 
              Glycosylation in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUT8 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fut81 , 5 fucosyltransferase 81, 5 91.77(n)1
    96.52(a)1
      12 (35.46 cM)5
    536181  NM_001252614.11  NP_001239543.11 
     772381045 
    chicken
    (Gallus gallus)
    Aves FUT81 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 83.48(n)
    93.91(a)
      423178  NM_001004766.1  NP_001004766.1 
    lizard
    (Anolis carolinensis)
    Reptilia FUT86
    Alpha-(1,6)-fucosyltransferase
    93(a)
    1 ↔ 1
    1(44582176-44655370)
    African clawed frog
    (Xenopus laevis)
    Amphibia fut8-A2 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 79.58(n)    AJ514872.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.53032 Transcribed sequence with weak similarity to protein more 76.07(n)    57057941 
    fruit fly
    (Drosophila melanogaster)
    Insecta FucT61 , 3 protein amino acid glycosylation
    glycoprotein
    more3
    alpha1,6-fucosyltransferase1
    46(a)3
    52.83(n)1
    50.09(a)1
      10D63
    321221  NM_132512.31  NP_572740.11 
    worm
    (Caenorhabditis elegans)
    Secernentea fut-81 Protein FUT-8 50.88(n)
    40.35(a)
      178985  NM_072154.4  NP_504555.2 


    ENSEMBL Gene Tree for FUT8 (if available)
    TreeFam Gene Tree for FUT8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6166 SNPs in FUT8 are shown (see all 6166)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs669111261,2
    C--46279920(+) AAAAT-/ACAC  
      ACACAC
    ACACA
    5 -- int10--------
    rs1878775261,2
    --65875312(+) TTAATA/GAGGAA 4 -- us2k10--------
    rs1921685081,2
    --65875348(+) AATCAA/GTAGTG 4 -- us2k10--------
    rs1837397321,2
    --65875531(+) TTTAAC/GGAGCT 4 -- us2k10--------
    rs1413264491,2
    --65875836(+) CCCAGA/GTGGGT 4 -- us2k10--------
    rs1156536041,2
    F--65875963(+) AAAACA/TACGAG 4 -- us2k11Minor allele frequency- T:0.02WA 118
    rs1172297471,2
    F--65875975(+) ACAATT/GAACAA 4 -- us2k11Minor allele frequency- G:0.01NA 120
    rs171026551,2
    C,F--65876031(+) GTAGAG/CATAGA 4 -- us2k1 tfbs34Minor allele frequency- C:0.03NA WA 260
    rs756361611,2
    C,F--65876120(+) CTCCCC/GACCGT 4 -- us2k11Minor allele frequency- G:0.08WA 118
    rs1451087951,2
    --65876292(+) TTCACA/TACTTA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for FUT8 (65877310 - 66127310 bp, first 250kb of FUT8)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for FUT8 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748794CNV Deletion23290073
    esv2748779CNV Deletion23290073
    esv2748793CNV Deletion23290073
    esv2748798CNV Deletion23290073
    esv2664690CNV Deletion23128226
    esv2748795CNV Deletion23290073
    esv1385928CNV Deletion17803354
    esv2413773CNV Deletion18987734
    esv2659861CNV Deletion23128226
    esv2677649CNV Deletion23128226


    Human Gene Mutation Database (HGMD): FUT8
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FUT8
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602589    OMIM disorders: --

    14 diseases for FUT8:    About MalaCards
    pancreatic acinar cell adenocarcinoma    recurrent respiratory papillomatosis    leukocyte adhesion deficiency    pulmonary emphysema
    congenital disorder of glycosylation    papillary carcinoma    gastric cancer    multiple sclerosis
    adenoma    adenocarcinoma    pancreatitis    hepatocellular carcinoma
    thyroiditis    lung cancer

    1 disease from the University of Copenhagen DISEASES database for FUT8:
    Pancreatic acinar cell adenocarcinoma

    FUT8 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for FUT8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 25.7 3 9378548 (1), 18754874 (1)
    gastric cancer 19 2 10580126 (1)
    metastasis 12.2 7 10232614 (1), 14568171 (1)
    tumors 0.976 5 10232614 (1), 14568171 (1), 9378548 (1), 10580126 (1)

    Genetic Association Database (GAD): FUT8
    Human Genome Epidemiology (HuGE) Navigator: FUT8 (3 documents)

    Export disorders for FUT8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT8 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with FUT8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic structure and promoter analysis of the human alpha1,6- fucosyltransferase gene (FUT8). (PubMed id 10814706)1, 2, 9 Yamaguchi Y.... Taniguchi N. (2000)
    2. Genomics meets glycomics-the first GWAS study of huma n N-Glycome identifies HNF1I+ as a master regulator of plasma protein fucosylati on. (PubMed id 21203500)1, 4 Lauc G....Rudan I. (2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. A sequence motif involved in the donor substrate binding by alpha1,6- fucosyltransferase: the role of the conserved arginine residues. (PubMed id 10764839)1, 2 Takahashi T....Taniguchi N. (2000)
    5. Evolution of fucosyltransferase genes in vertebrates. (PubMed id 9368041)1, 3 Costache M....Mollicone R. (1997)
    6. Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D- glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells. (PubMed id 9133635)1, 2 Yanagidani S....Taniguchi N. (1997)
    7. Crystal structure of mammalian alpha1,6-fucosyltransferase, FUT8. (PubMed id 17172260)1, 9 Ihara H....Taniguchi N. (2007)
    8. The alpha1-6-fucosyltransferase gene and its biological significance. (PubMed id 10580126)1, 9 Miyoshi E....Taniguchi N. (1999)
    9. Reaction mechanism and substrate specificity for nucleotide sugar of mammalian alpha1,6-fucosyltransferase--a large-scale preparation and characterization of recombinant human FUT8. (PubMed id 16344263)1, 9 Ihara H....Taniguchi N. (2006)
    10. Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation. (PubMed id 14568171)1, 9 Ito Y....Miyoshi E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2530 HGNC: 4019 AceView: FUT8 Ensembl:ENSG00000033170 euGenes: HUgn2530
    ECgene: FUT8 Kegg: 2530 H-InvDB: FUT8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FUT8 Genetics and Cytogenetics in Oncology and Haematology
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT8
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_605

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FUT8 gene:
    Search GeneIP for patents involving FUT8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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