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Aliases for FUT7 Gene

Aliases for FUT7 Gene

  • Fucosyltransferase 7 2 3 4
  • Fucosyltransferase 7 (Alpha (1,3) Fucosyltransferase) 2 3 5
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Selectin Ligand Synthase 3 4
  • Fucosyltransferase VII 3 4
  • Fuc-TVII 3 4
  • FucT-VII 3 4
  • Alpha (1,3) Fucosyltransferase 2
  • Selectin-Ligand Synthase 3
  • EC 63
  • EC 2.4.1.- 4
  • EC 2.4.1 63

External Ids for FUT7 Gene

Previous GeneCards Identifiers for FUT7 Gene

  • GC09P131057
  • GC09M131614
  • GC09M133365
  • GC09M135281
  • GC09M137200
  • GC09M139044
  • GC09M139924
  • GC09M109383

Summaries for FUT7 Gene

Entrez Gene Summary for FUT7 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X antigens. The encoded protein can direct the synthesis of the E-selectin-binding sialyl-Lewis X moiety. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT7 Gene

FUT7 (Fucosyltransferase 7) is a Protein Coding gene. Diseases associated with FUT7 include Ehrlichiosis and Human Granulocytic Anaplasmosis. Among its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism. GO annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT7 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.

Gene Wiki entry for FUT7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT7 Gene

Genomics for FUT7 Gene

Regulatory Elements for FUT7 Gene

Enhancers for FUT7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FUT7 on UCSC Golden Path with GeneCards custom track

Promoters for FUT7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUT7 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUT7 Gene

137,030,174 bp from pter
137,033,010 bp from pter
2,837 bases
Minus strand

Genomic View for FUT7 Gene

Genes around FUT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT7 Gene

Proteins for FUT7 Gene

  • Protein details for FUT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 7
    Protein Accession:
    Secondary Accessions:
    • B2R7U7
    • Q6DK54

    Protein attributes for FUT7 Gene

    342 amino acids
    Molecular mass:
    39239 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT7 Gene

Proteomics data for FUT7 Gene at MOPED

Selected DME Specific Peptides for FUT7 Gene

Post-translational modifications for FUT7 Gene

  • Glycosylation at Asn 81 and Asn 291
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT7 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FUT7 (Fucosyltransferase 7/FUT7)
  • Abcam antibodies for FUT4

Domains & Families for FUT7 Gene

Gene Families for FUT7 Gene

Protein Domains for FUT7 Gene

Suggested Antigen Peptide Sequences for FUT7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 10 family.
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT7: view

Function for FUT7 Gene

Molecular function for FUT7 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),7 (FucT-VII),leukocyte,catalyzing in sialyl-Lewis X synthesis
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-L-fucose + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R = GDP + alpha-2,3-Neu-N-acetyl-1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens.

Enzyme Numbers (IUBMB) for FUT7 Gene

genes like me logo Genes that share phenotypes with FUT7: view

Animal Models for FUT7 Gene

MGI Knock Outs for FUT7:

Animal Model Products

miRNA for FUT7 Gene

miRTarBase miRNAs that target FUT7

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT7 Gene

Localization for FUT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT7 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

Jensen Localization Image for FUT7 Gene COMPARTMENTS Subcellular localization image for FUT7 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT7: view

Pathways & Interactions for FUT7 Gene

genes like me logo Genes that share pathways with FUT7: view

UniProtKB/Swiss-Prot Q11130-FUT7_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT7 Gene

Gene Ontology (GO) - Biological Process for FUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002522 leukocyte migration involved in immune response IEA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT7: view

No data available for SIGNOR curated interactions for FUT7 Gene

Drugs & Compounds for FUT7 Gene

(1) Drugs for FUT7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(9) Additional Compounds for FUT7 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
genes like me logo Genes that share compounds with FUT7: view

Transcripts for FUT7 Gene

mRNA/cDNA for FUT7 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT7 Gene

Fucosyltransferase 7 (alpha (1,3) fucosyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT7 Gene

No ASD Table

Relevant External Links for FUT7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUT7 Gene

mRNA expression in normal human tissues for FUT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUT7 Gene

This gene is overexpressed in Whole Blood (x45.3).

Protein differential expression in normal tissues from HIPED for FUT7 Gene

This gene is overexpressed in Spleen (45.3) and Adipocyte (23.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FUT7 Gene

SOURCE GeneReport for Unigene cluster for FUT7 Gene Hs.457

mRNA Expression by UniProt/SwissProt for FUT7 Gene

Tissue specificity: Leukocytic/myeloid lineage cells.
genes like me logo Genes that share expression patterns with FUT7: view

Protein tissue co-expression partners for FUT7 Gene

Primer Products

Orthologs for FUT7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FUT7 35
  • 83.62 (n)
  • 82.25 (a)
FUT7 36
  • 82 (a)
(Canis familiaris)
Mammalia FUT7 35
  • 80.21 (n)
  • 78.95 (a)
FUT7 36
  • 80 (a)
(Mus musculus)
Mammalia Fut7 35
  • 78.5 (n)
  • 80.47 (a)
Fut7 16
Fut7 36
  • 70 (a)
(Rattus norvegicus)
Mammalia Fut7 35
  • 79.63 (n)
  • 80.99 (a)
(Monodelphis domestica)
Mammalia FUT7 36
  • 61 (a)
(Ornithorhynchus anatinus)
Mammalia FUT7 36
  • 61 (a)
(Gallus gallus)
Aves FUT7 35
  • 62.26 (n)
  • 54.08 (a)
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fut7 35
  • 60.55 (n)
  • 52.79 (a)
(Danio rerio)
Actinopterygii LOC100333727 35
  • 53.01 (n)
  • 45.9 (a)
Species with no ortholog for FUT7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUT7 Gene

Gene Tree for FUT7 (if available)
Gene Tree for FUT7 (if available)

Paralogs for FUT7 Gene

Paralogs for FUT7 Gene

(5) SIMAP similar genes for FUT7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUT7: view

Variants for FUT7 Gene

Structural Variations from Database of Genomic Variants (DGV) for FUT7 Gene

Variant ID Type Subtype PubMed ID
nsv469918 CNV Loss 18288195
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8415n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
nsv894483 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894500 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894503 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8425n71 CNV Loss 21882294
nsv894514 CNV Loss 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8433n71 CNV Gain 21882294
nsv894550 CNV Gain 21882294
dgv8437n71 CNV Gain 21882294
dgv8438n71 CNV Loss 21882294
dgv8439n71 CNV Loss 21882294
nsv894565 CNV Loss 21882294
dgv8440n71 CNV Loss 21882294
nsv894567 CNV Loss 21882294

Variation tolerance for FUT7 Gene

Residual Variation Intolerance Score: 93.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.92; 48.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT7 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FUT7 Gene

Disorders for FUT7 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FUT7 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • human ehrlichiosis
human granulocytic anaplasmosis
  • hge
- elite association - COSMIC cancer census association via MalaCards
Search FUT7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FUT7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT7 Gene

Publications for FUT7 Gene

  1. Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. (PMID: 8182079) Sasaki K. … Nishi T. (J. Biol. Chem. 1994) 2 3 4 23 67
  2. Molecular cloning of a cDNA encoding a novel human leukocyte alpha- 1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant. (PMID: 8207002) Natsuka S. … Lowe J.B. (J. Biol. Chem. 1994) 2 3 23
  3. Alpha1,3 fucosyltransferase VII plays a role in colorectal carcinoma metastases by promoting the carbohydration of glycoprotein CD24. (PMID: 20428816) Li W. … Li J. (Oncol. Rep. 2010) 3 23
  4. Overexpression of fucosyltransferase VII (FUT7) promotes embryo adhesion and implantation. (PMID: 18402946) Zhang Y. … Yan Q. (Fertil. Steril. 2009) 3 23
  5. Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII. (PMID: 15579466) Martinez M. … Spertini O. (J. Biol. Chem. 2005) 3 23

Products for FUT7 Gene

Sources for FUT7 Gene