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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT6 Gene

protein-coding   GIFtS: 63
GCID: GC19M005830

Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase)

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase)1 2     3)-fucosyltransferase1
Galactoside 3-L-Fucosyltransferase1 2 3     alpha-(11
Fucosyltransferase VI2 3     FT1A2
FCT3A2 3     Alpha-(1,3)-Fucosyltransferase 62
Fuc-TVI2 3     Fucosyltransferase 63
FucT-VI2 3     EC 2.4.18
EC 2.4.1.653 8     

External Ids:    HGNC: 40171   Entrez Gene: 25282   Ensembl: ENSG000001564137   OMIM: 1368365   UniProtKB: P519933   

Export aliases for FUT6 gene to outside databases

Previous GC identifers: GC19M005922 GC19M005771 GC19M005781 GC19M005759 GC19M005590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FUT6 Gene:
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of
sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two
transcript variants encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FUT6 Gene: 
FUT6 (fucosyltransferase 6 (alpha (1,3) fucosyltransferase)) is a protein-coding gene. Diseases associated with FUT6 include cytomegalovirus infection, and herpes simplex, and among its related super-pathways are Metabolism. GO annotations related to this gene include 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and fucosyltransferase activity. An important paralog of this gene is FUT5.

UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
Function: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of
fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates

Gene Wiki entry for FUT6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011255.14  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT6 gene promoter:
         c-Fos   HOXA9   HOXA9B   AP-1   C/EBPalpha   Meis-1b   Pax-3   CP2   c-Jun   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): FUT6 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FUT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005830:  view genomic region     (about GC identifiers)

Start:
5,830,621 bp from pter      End:
5,839,742 bp from pter
Size:
9,122 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993 (See protein sequence)
Recommended Name: Alpha-(1,3)-fucosyltransferase  
Size: 359 amino acids; 41860 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Note=Membrane-bound form in trans cisternae of Golgi
Sequence caution: Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A6NEX0 D6W637 Q9UND8
Alternative splicing: 2 isoforms:  P51993-1   P51993-2   

Explore the universe of human proteins at neXtProt for FUT6: NX_P51993

Explore proteomics data for FUT6 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51993

  • 4/19 DME Specific Peptides for FUT6 (P51993) (see all 19)
     VPVVLGP  CFFSYLR  FIHVDDF  ADCNITA 

    FUT6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FUT6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000141.1  NP_001035791.1  

    ENSEMBL proteins: 
     ENSP00000431708   ENSP00000432954   ENSP00000286955   ENSP00000466016   ENSP00000436547  
     ENSP00000432161   ENSP00000436413   ENSP00000431880   ENSP00000433811   ENSP00000313398  

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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for FUT6 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS11698403
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    FUT6 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FUT: Fucosyltransferases

    1 InterPro protein domain:
     IPR001503 Glyco_trans_10

    Graphical View of Domain Structure for InterPro Entry P51993

    ProtoNet protein and cluster: P51993

    1 Blocks protein domain: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
    Similarity: Belongs to the glycosyltransferase 10 family


    FUT6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT6_HUMAN, P51993
    Function: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of
    fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates
    Catalytic activity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +
    beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R

         Genatlas biochemistry entry for FUT6:
    fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteins
    produced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with
    a FUT6 missense mutation,with a high allelic diversity,ethnic specific

         Enzyme Numbers (IUBMB): EC 2.4.1.651 2 EC 2.4.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008417fucosyltransferase activity TAS8175676
    GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA--
    GO:0046920alpha-(1->3)-fucosyltransferase activity TAS11698403
         
    FUT6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FUT6:
     Increased S DNA content 

    Animal Models:
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FUT6 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    2         Kegg Pathways  (Kegg details for FUT6):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
    Pathway: Protein modification; protein glycosylation


    FUT6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for FUT6 (ENSP000002869554) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GNT2ENSP000003055954STRING: ENSP00000305595
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    B4GALT3ENSP000003209654STRING: ENSP00000320965
    FUT1ENSP000003120214STRING: ENSP00000312021
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS11698403
    GO:0036065fucosylation TAS8175676
    GO:0042355L-fucose catabolic process NAS11698403

    FUT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT6

    2 HMDB Compounds for FUT6    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    5 Novoseek inferred chemical compound relationships for FUT6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 67.2 2 7630015 (1), 12725333 (1)
    polylactosamine 66.4 1 10622713 (1)
    n-acetyllactosamine 54.8 1 10891123 (1)
    n-ethylmaleimide 34.2 1 9042366 (1)
    n-acetylglucosamine 32 1 10052591 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT6

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FUT6 gene (2 alternative transcripts): 
    NM_000150.2  NM_001040701.1  

    Unigene Clusters for FUT6:

    Fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
    Hs.631846  [show with all ESTs], Hs.705615  [show with all ESTs]
    Unigene Representative Sequences: NM_000150, U27331
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524754(uc021unl.1) ENST00000527106 ENST00000286955 ENST00000592563
    ENST00000529165 ENST00000531085 ENST00000531199 ENST00000532464 ENST00000528505
    ENST00000526499 ENST00000591079 ENST00000318336(uc002mdf.1 uc002mdg.1 uc002mdh.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FUT6:
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    Additional mRNA sequence: U27331.1 

    9 DOTS entries:

    DT.95243192  DT.86994016  DT.99952233  DT.100019203  DT.100750043  DT.75105001  DT.97777317  DT.99978277 
    DT.121449794 

    22 AceView cDNA sequences:

    U27332 U27331 BC061700 AW614132 BV198781 M98825 AF131211 U27336 
    BM756773 AK098073 BX113350 BV198591 AL702935 AI672482 AI952786 BG432556 
    AU098944 BG952128 BE833439 BG402446 AW176527 BV198613 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FUT6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
    SP1:              -                                                         
    SP2:              -           -     -     -                                 
    SP3:                          -     -     -                                 
    SP4:                                                                        


    ECgene alternative splicing isoforms for FUT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCACGTG
    FUT6 Expression
    About this image


    See FUT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT6

    SOURCE GeneReport for Unigene clusters: Hs.631846 Hs.705615

    UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
    Tissue specificity: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUT6 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia FUT56
    FUT56
    --
    68(a)
    67(a)
    many ↔ many
    many ↔ many
    20(54208840-54209892)
    20(54224690-54225841)
    chicken
    (Gallus gallus)
    Aves FUT36
    Uncharacterized protein
    46(a)
    1 → many
    28(1498656-1499789)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    1 → many
    AAWZ02038436(4451-5581)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3990492 alpha 1,3/4 fucosyltransferase Lewis 1 74.41(n)    AJ580005.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fut96
    --
    (see all 15)
    --
    35(a)
    35(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    8(3512976-3517595)
    8(3626455-3650896)
    worm
    (Caenorhabditis elegans)
    Secernentea fut-41 Protein FUT-4 42.45(n)
    32.53(a)
      187342  NM_061971.3  NP_494372.2 


    ENSEMBL Gene Tree for FUT6 (if available)
    TreeFam Gene Tree for FUT6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT6 gene
    FUT52  FUT42  FUT72  FUT32  FUT112  FUT102  FUT92  
    5 SIMAP similar genes for FUT6 using alignment to 7 protein entries:     FUT6_HUMAN (see all proteins):
    FUT5    FUT3    FUT9    FUT7    FUT4

    FUT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
    Polymorphism: Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of
    individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma
    alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong
    linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma
    alpha(1,3)-fucosyltransferase deficiency [MIM:613852]


    267/345 SNPs in FUT6 are shown (see all 345)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178557391,2,4
    C,Fpathogenic16856794(-) CCTTCG/AAGAAC 4 /K /E mis1 ese34Minor allele frequency- A:0.12NA EU 5867
    VAR_0659154
    ----see VAR_0659152 L V mis40--------
    rs7788091,2
    C,F,O,A,H--5590150(+) ACACCG/AGATGA 2 -- ds500135Minor allele frequency- A:0.49NS EA NA WA CSA 3408
    rs1380966471,2
    --5590167(+) CTCTCA/TCACAC 2 -- ds50010--------
    rs2000714221,2
    --5590290(+) ACACT-/CCCCCC 2 -- ds50010--------
    rs7788081,2
    C,F,A,H--5590295(-) AAAAAA/GGGGGG 2 -- ds500121Minor allele frequency- G:0.14NS EA NA WA CSA 1996
    rs3713273451,2
    C--5590295(+) CCCCC-/C/TTTTTT 2 -- ds50010--------
    rs597688851,2
    C--5590485(+) TTTTT-/T/TTT 
            
    GAGAC
    4 -- ds5001 cds11NA 2
    rs1817784131,2
    --5590505(+) TCTGTC/TGCCAG 2 -- ut310--------
    rs1859113951,2
    C--5590552(+) CCTCCA/GACTCT 2 -- ut310--------
    rs1903256681,2
    --5590568(+) TCAAGC/TGATTC 2 -- ut310--------
    rs7788071,2
    C,H--5590627(-) TTTGCT/CGGGCG 2 -- ut31 ese34Minor allele frequency- C:0.00NA WA CSA 7
    rs358450411,2
    C--5590647(+) TTTTAG/ATAGAG 2 -- ut311Minor allele frequency- A:0.50NA 2
    rs1883903431,2
    --5590654(+) AGAGAC/TGGGTT 2 -- ut310--------
    rs1388148001,2
    --5590758(+) GCACCC/TGGCCT 2 -- ut310--------
    rs129863681,2
    C,F,H--5590770(+) ATCATC/TGGTTT 2 -- ut31 ese313Minor allele frequency- T:0.25NS EA NA WA 912
    rs7788061,2
    C,F,H--5590777(-) GCAAAG/AAAAAC 2 -- ut318Minor allele frequency- A:0.06NS EA WA 1208
    rs1427745881,2
    C--5590835(+) ACAGGC/TGGCTA 2 -- ut310--------
    rs1910833631,2
    --5590848(+) AACATC/TACAAA 2 -- ut310--------
    rs1829300801,2
    C--5590949(+) TGAGGC/TTCCTA 2 -- ut310--------
    rs1866550161,2
    --5590955(+) TCCTAC/GCAGGT 2 -- ut310--------
    rs1167940361,2
    C,F--5591044(+) GTCCCC/TAGGAG 2 -- ut311Minor allele frequency- T:0.04WA 118
    rs1473772031,2
    --5591099(+) CCAGCA/TTGTGA 2 -- ut310--------
    rs2013665291,2
    C--5591341(+) ACACCA/GGCCTC 2 -- ut311Minor allele frequency- G:0.00EU 1323
    rs1505722331,2
    C,F--5591363(+) AAGCCG/TCTATG 4 E A mis11Minor allele frequency- T:0.00NA 4546
    rs2012789611,2
    C--5591373(+) GCCGCG/ATGTCT 4 /R /C mis11Minor allele frequency- A:0.00EU 1323
    rs1925457271,2
    C--5591404(+) AGTTTC/TCAGCA 4 * W stg10--------
    rs617405611,2
    C,F--5591425(+) AAAGCG/CAGTGC 4 /L syn17Minor allele frequency- C:0.08NS CSA WA NA EU 6014
    rs3752421621,2
    C--5591445(+) GGAGCA/GAGGCC 4 R C mis10--------
    rs617395521,2
    C,F--5591450(+) GAGGCC/TGCAGC 4 Q R mis13Minor allele frequency- T:0.03NS NA EU 5907
    rs617395511,2
    C,F--5591456(+) GCAGCG/ATCTCC 4 /T /M mis12Minor allele frequency- A:0.01NS EU 1131
    rs1450356791,2
    C,F--5591482(+) CTCAGG/TTAGCG 4 * Y stg12Minor allele frequency- T:0.01NA EU 5845
    rs1429154111,2
    C--5591519(+) GGTACC/TGGGCC 4 Q R mis11Minor allele frequency- T:0.00NA 4434
    rs611479391,2,4
    C,F--5591520(+) GTACCG/CGGCCA 4 /R /G mis11Minor allele frequency- C:0.03EU 1029
    rs1410553821,2
    F--5591545(+) TGGAAG/ATCGTC 4 /D syn11Minor allele frequency- A:0.00NA 4146
    rs621102611,2
    C,F--5591548(+) AAGTCG/ATCCAC 4 /D syn11Minor allele frequency- A:0.01EU 943
    rs2007793571,2
    C--5591569(+) GCGTCG/AGGTGG 4 /P syn11Minor allele frequency- A:0.00EU 1153
    rs1123130641,2
    C,F--5591572(+) TCGGGT/CGGCAG 4 /P syn12Minor allele frequency- C:0.19WA EU 701
    rs1469417961,2
    C,F--5591573(+) CGGGTG/AGCAGG 4 /P /L mis11Minor allele frequency- A:0.00NA 3632
    rs1500556991,2
    C,F--5591617(+) ACCACG/AGGCAC 4 /P syn11Minor allele frequency- A:0.00NA 3746
    rs1997184411,2
    --5591658(+) CTTCTC/TGGTGA 4 K E mis10--------
    rs1413492151,2
    C,F--5591689(+) TTCTCG/AAAGGC 4 /F syn12Minor allele frequency- A:0.02NA EU 5876
    rs793597591,2
    C,F--5591698(+) GCCAGA/GTAGAA 4 Y syn12Minor allele frequency- G:0.02CSA NA 4554
    rs1460773441,2
    C--5591720(+) ACAGCG/ATCTCC 4 /T /M mis11Minor allele frequency- A:0.00NA 4552
    rs4439071,2
    A--5591734(-) CAGGGA/GACCAT 4 G syn1 ese31Minor allele frequency- G:0.00NA 2
    rs3646371,2,4
    C,F,A,H--5591739(-) TGCCCC/AAGGGA 4 /K /Q mis1 ese310Minor allele frequency- A:0.09EA NA NS MN 5212
    rs1419456461,2
    F--5591760(+) GGAGCG/ATCCGT 4 /R /C mis11Minor allele frequency- A:0.00NA 4550
    rs1463124461,2
    F--5591763(+) GCGTCC/TGTACA 4 R G mis11Minor allele frequency- T:0.00NA 4550
    rs1923159921,2
    C--5591769(+) GTACAC/TGTCCA 4 M V mis10--------
    rs3645871,2
    C,F--5591785(-) CAGGCC/TCATCT 4 A syn1 ese35Minor allele frequency- T:0.00MN NA EU 6061
    rs4458781,2
    C--5591818(+) CTGGCA/C/G/
            
    GAGTT
    8 S syn1 ese33NA 4554
    rs39646311,2
    H--5591823(-) GGCCAA/GACTCC 4 N D mis14Minor allele frequency- G:0.00NS EA 414
    rs40414731,2
    H--5591824(-) GGGCCA/GAACTC 4 P syn14Minor allele frequency- G:0.00NS EA 420
    rs28794011,2
    --5591828(-) CTGGGA/GGCCAA 4 E G mis10--------
    rs4015081,2
    C--5591842(+) GACACC/TGCCCA 4 A syn1 ese33Minor allele frequency- T:0.12NA MN 188
    rs1468195881,2
    C,F--5591876(+) AGAGGT/CTGAGC 4 /N /S mis11Minor allele frequency- C:0.00NA 4488
    rs1450090201,2
    C,F--5591889(+) TGGGTG/AGGCAG 4 /H /Y mis12Minor allele frequency- A:0.00NA EU 5711
    rs1114943841,2
    F--5591900(+) GCTGGC/ACGGAC 4 /G /V mis11Minor allele frequency- A:0.50CSA 4
    rs1509244441,2
    C--5591902(+) TGGCCG/AGACCA 4 /S syn11Minor allele frequency- A:0.00NA 4422
    rs1505609311,2
    C--5591925(+) CCGTA-/GGGGCG 4 Y LR fra10--------
    rs2008975721,2
    C--5592038(+) TCCATC/TGCTGC 4 Q R mis10--------
    rs2016340231,2
    --5592050(+) CCTGCC/TGCCTC 4 Q R mis10--------
    rs1115894521,2
    C,F--5592051(+) CTGCCG/ACCTCG 4 /R /W mis11Minor allele frequency- A:0.50CSA 4
    rs1851084161,2
    C--5592055(+) CGCCTC/TGGGGA 4 P syn10--------
    rs7788051,2,4
    C,F,A,H--5592057(-) GCTCCC/TCGAGG 4 P S mis127Minor allele frequency- T:0.44NS EA NA CSA WA EU 8401
    rs1899599831,2
    --5592058(+) CTCGGA/GGAGCG 4 S syn10--------
    rs1386451251,2
    C,F--5592063(+) GGAGCG/ATGGGA 4 /R /C mis12Minor allele frequency- A:0.00NA EU 5867
    rs1154050041,2
    C--5592067(+) CGTGGG/AAGCTG 4 /L syn12Minor allele frequency- A:0.00WA NA 4668
    rs1144609691,2
    C,F--5592091(+) TACATG/TACCTC 4 V syn12Minor allele frequency- T:0.01WA NA 4668
    rs724863541,2
    C--5592098(+) CCTCTC/TGGTGG 4 Q R mis10--------
    rs1926154411,2
    C--5592099(+) CTCTCC/GGTGGT 4 R G mis10--------
    rs1388579151,2
    F--5592115(+) ATGACC/TGCGTC 4 A syn11Minor allele frequency- T:0.00NA 4550
    rs1506925101,2
    C--5592223(+) GGCCAC/TGTCCA 4 T syn11Minor allele frequency- T:0.00NA 4546
    rs1128490791,2
    C,F--5592255(+) GTGGGC/TGGGGG 4 T A mis11Minor allele frequency- T:0.50CSA 4
    rs1997915981,2
    C--5592289(+) GACCCA/GTTAGG 4 N syn11Minor allele frequency- G:0.00EU 1307
    rs1410624041,2
    C--5592309(+) GGGATC/TGTCTT 4 N D mis11Minor allele frequency- T:0.00NA 4530
    rs2022154731,2
    --5592312(+) ATCGTC/TTTGAG 4 N D mis10--------
    rs1448073241,2
    C,F--5592323(+) ACACAC/TGCAGA 4 H R mis11Minor allele frequency- T:0.00NA 4518
    rs2015244471,2
    --5592324(+) CACACA/GCAGAT 4 R C mis10--------
    rs1137647061,2
    C,F--5592364(+) TGAAAC/TAGCAG 4 L syn11Minor allele frequency- T:0.50CSA 2
    rs1436689271,2
    C,F--5592409(+) TTGGCC/TGGGCC 4 P syn11Minor allele frequency- T:0.01NA 4490
    rs98078771,2
    C,F--5592437(+) AGAGTA/CTCTGG 2 -- ut5117Minor allele frequency- C:0.39NA WA CSA EA EU 1811
    rs7788041,2
    C,F,A,H--5592540(-) CTGTGA/TAACAG 2 -- int113Minor allele frequency- T:0.16NA WA CSA EA 379
    rs780606981,2
    C,F--5592621(+) GCCCAG/AAGTCC 2 -- int13Minor allele frequency- A:0.04WA NA EA 358
    rs1480818941,2
    --5592645(+) CATTAA/GACAAC 2 -- int10--------
    rs1409023721,2
    --5592693(+) TGGGAA/GAGGCC 2 -- int10--------
    rs39160801,2
    C,F,A,H--5592747(-) TCTGGG/TGACAC 2 -- int118Minor allele frequency- T:0.24NA EA NS 1820
    rs1879967411,2
    --5592783(+) ACAGCC/TGATCA 2 -- int10--------
    rs735366161,2
    C,F--5592785(+) AGCCGA/GTCATA 2 -- int14Minor allele frequency- G:0.12WA CSA EA 242
    rs1161562701,2
    F--5592814(+) TGAGTC/TGAGGC 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1818951811,2
    C--5592830(+) CCCATA/GACTCT 2 -- int10--------
    rs38595631,2
    C,F,A,H--5592885(-) CTGGTA/GAGCTC 2 -- int131Minor allele frequency- N:0.00NS EA NA WA CSA 2988
    rs1864541281,2
    --5592912(+) GGAAAC/GGGTGC 2 -- int10--------
    rs744215451,2
    C,F--5592961(+) GGAGAG/CACCCC 2 -- int11Minor allele frequency- C:0.03NA 120
    rs1501650461,2
    --5593004(+) TCAGGA/GCTGCC 2 -- int10--------
    rs1892991121,2
    C--5593121(+) GAAGCC/TGAGGC 2 -- int10--------
    rs104201071,2
    C,F--5593127(+) gaggcG/Aggcag 2 -- int15Minor allele frequency- A:0.40NA WA CSA 10
    rs1428058551,2
    --5593144(+) AGGTCA/GAGAGA 2 -- int10--------
    rs1820768581,2
    C--5593275(+) CCTGGC/GGGGTG 2 -- int10--------
    rs1866300681,2
    --5593278(+) GGGGGA/GTGGAG 2 -- int10--------
    rs1113422701,2
    C,F--5593307(+) CGCACC/TGCTGC 2 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1380266471,2
    C--5593398(+) TGCCTA/GTAATC 2 -- int10--------
    rs104027281,2
    C,F,A--5593470(+) caacgC/Tggtga 2 -- int16Minor allele frequency- T:0.50NA WA CSA 12
    rs1137697741,2
    C,F--5593535(+) TAATCC/ACAGCT 2 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs1429960531,2
    C--5593633(+) GGACAA/CAGAAT 2 -- int10--------
    rs1914741441,2
    --5593728(+) GCTCAC/TGACTG 2 -- int10--------
    rs735366261,2
    C,F--5593774(+) TAACTT/AGAGGT 2 -- int16Minor allele frequency- A:0.14WA CSA EA 246
    rs349409031,2
    C,F--5593797(+) ACCAGC/TGTGGT 2 -- int17Minor allele frequency- T:0.25WA NA EA 366
    rs124608741,2
    C,F,H--5593815(+) GAGAAC/TCCACA 2 -- int16Minor allele frequency- T:0.20NA WA EA 364
    rs800532501,2
    C,F--5593846(+) ATTAGC/TTGGGC 2 -- int14Minor allele frequency- T:0.50WA CSA 8
    rs1131806031,2
    C,F--5593978(+) AGAGCG/AAGACC 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs2018186351,2
    C--5593997(+) AAAAGA/GAAAAA 2 -- int10--------
    rs735366291,2
    C,F--5594029(+) CACTCA/GGGGTT 2 -- int16Minor allele frequency- G:0.10WA CSA NA EA 364
    rs172718831,2
    C,F,H--5594060(+) GGTTAC/TTCCTC 2 -- int130Minor allele frequency- T:0.50NA NS EA WA CSA 2910
    rs1828013901,2
    --5594063(+) TACTCC/TTCTGG 2 -- int10--------
    rs98078171,2
    C--5594098(+) GGGACA/C/TGATAG 2 -- int10--------
    rs1853194501,2
    --5594121(+) GCAGGC/TGTGGG 2 -- int10--------
    rs104031151,2
    C,F,H--5594193(+) AGAAGC/AAGGCT 2 -- int110Minor allele frequency- A:0.03NS EA NA WA 1094
    rs1900289921,2
    --5594295(+) TCCCCC/TGGAGT 2 -- int10--------
    rs1438148461,2
    --5594362(+) GCTCAC/TGCCTG 2 -- int10--------
    rs1129482121,2
    C--5594700(+) GTGGCG/AGGAAA 2 -- int11Minor allele frequency- A:0.50CSA 2
    rs1468388791,2
    --5594759(+) GGACCC/TTTGGA 2 -- int10--------
    rs1142391311,2
    F--5594937(+) ACTGTG/TTCCGT 2 -- int11Minor allele frequency- T:0.03WA 118
    rs1822605821,2
    --5595062(+) GACCCC/TAGATC 2 -- int10--------
    rs1406273641,2
    --5595075(+) GACCTC/TGGGAA 2 -- int10--------
    rs1880295791,2
    --5595125(+) TGCAGA/CCCTAC 2 -- int10--------
    rs1500063521,2
    --5595144(+) ATTCTA/GCAGAT 2 -- int10--------
    rs1930594121,2
    --5595162(+) CTAAGA/GCTCAG 2 -- int10--------
    rs1134267731,2
    C,F--5595224(+) CAGACT/CCCAAA 2 -- int11Minor allele frequency- C:0.00CSA 1
    rs1149148941,2
    F--5595278(+) CAGATG/AGAGCT 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1491381481,2
    C--5595386(+) GTGGGC/TGGATT 2 -- int10--------
    rs120191361,2
    C--5595494(+) TACTCA/GGGAGG 2 -- int10--------
    rs1413994911,2
    --5595540(+) AGGTTG/TCAGTG 2 -- int10--------
    rs1837616521,2
    --5595557(+) GATTGC/TACCAT 2 -- int10--------
    rs1882419651,2
    --5595597(+) ACTCCA/GTCTCA 2 -- int10--------
    rs1469892391,2
    C--5595758(+) GTCGCC/TCAGAC 2 -- int10--------
    rs1929343791,2
    --5595860(+) TACAAC/GTGTGC 2 -- int10--------
    rs1845698481,2
    --5595901(+) TAGTAA/GAGACG 2 -- int10--------
    rs1180743131,2
    C,F--5595980(+) GCCTCC/TCAAAG 2 -- int11Minor allele frequency- T:0.06EA 120
    rs1885433151,2
    --5596021(+) CCGGCA/CTGGCT 2 -- int10--------
    rs1399994311,2
    C--5596044(+) TTTTC-/TTTTCT
    TTTCTTTTG
    TTTTC
    2 -- cds10--------
    rs1380921431,2
    --5596128(+) AACCTC/GCGCCT 2 -- int10--------
    rs1416998601,2
    --5596418(+) TTGGGC/TGGCTG 2 -- int10--------
    rs1914542331,2
    --5596426(+) CTGAGA/GTGGGA 2 -- int10--------
    rs1501115261,2
    --5596437(+) GGATCA/GCTTGA 2 -- int10--------
    rs1835429901,2
    --5596543(+) ACATGC/GTGGCC 2 -- int10--------
    rs1384179491,2
    --5596577(+) CTGAGG/TCAGGA 2 -- int10--------
    rs1492478151,2
    --5596632(+) TGCACC/TATTGC 2 -- int10--------
    rs1461726661,2
    --5596664(+) TGAGAC/TCGTGT 2 -- int10--------
    rs1452754991,2
    C--5596674(+) TCTCA-/AAAT  
            
    AAATA
    2 -- int10--------
    rs16788491,2
    C,F,H--5596781(+) GACTGA/GTATTA 2 -- int135Minor allele frequency- G:0.23NS EA NA WA CSA 3099
    rs1174498051,2
    C,F--5596797(+) AGTAAT/CTGGGA 2 -- int12Minor allele frequency- C:0.04NA EA 240
    rs1401932601,2
    --5596806(+) GAAACC/TTTTGA 2 -- int10--------
    rs615469921,2
    C--5597014(+) GCGCCC/TCCCAC 2 -- int10--------
    rs603830671,2
    C--5597102(+) CTCAAC/TTGACC 2 -- int11Minor allele frequency- T:0.50NA 2
    rs2013209271,2
    --5597151(+) TGAGT-/CACCACCA 2 -- cds10--------
    rs1485579761,2
    --5597317(+) GCCAGG/TCACGG 2 -- int10--------
    rs1428970391,2
    --5597321(+) GGCACA/GGTGGC 2 -- int10--------
    rs352220811,2
    C,F--5597328(+) TGGCTC/TATGCC 2 -- int15Minor allele frequency- T:0.33NA WA 128
    rs1893994611,2
    --5597412(+) ACATGC/GTGAAA 2 -- int10--------
    rs1510634601,2
    --5597538(+) GCAGTC/GAGCCA 2 -- int10--------
    rs1819605351,2
    C--5597548(+) AAGGTC/TGCGCC 2 -- int10--------
    rs1996531331,2
    C--5597621(+) TAAAA-/AAATAA 2 -- int10--------
    rs1397329321,2
    C--5597820(+) GCTGTC/TGGGCT 2 -- int10--------
    rs1869981911,2
    --5597938(+) TTTGCC/TGGTGA 2 -- int10--------
    rs1897982851,2
    --5597977(+) GGGAAC/TGGGAG 2 -- int10--------
    rs1446306051,2
    --5598028(+) ATGATC/TGATCC 2 -- int10--------
    rs1478685441,2
    C--5598106(+) CCACCA/GGGAGT 2 -- int10--------
    rs1818531001,2
    --5598110(+) CGGGAA/GTGGCA 2 -- int10--------
    rs1414682401,2
    --5598143(+) AGGAAA/GGATGA 2 -- int10--------
    rs81013851,2
    C,F,A,H--5598412(+) CAGGAC/TTGAGG 2 -- int121Minor allele frequency- T:0.28NS EA NA WA CSA 2348
    rs1858564491,2
    --5598435(+) GGCTCA/GGAGCC 2 -- int10--------
    rs1470059311,2
    --5598470(+) CGATCC/TGGGTT 2 -- int10--------
    rs759988591,2
    F--5598471(+) GATCCG/AGGTTG 2 -- int11Minor allele frequency- A:0.01NA 120
    rs1476253951,2
    --5598477(+) GGTTGG/TGGGTG 2 -- int10--------
    rs739200691,2
    C,F--5598546(+) GAGGCC/TGCGGA 2 -- ut513Minor allele frequency- T:0.06WA CSA 122
    rs1901826781,2
    --5598597(+) ACCACA/GCAGCA 2 -- ut510--------
    rs1167926591,2
    C,F--5598653(+) AACCAC/ACACAC 2 -- ut511Minor allele frequency- A:0.02WA 118
    rs1823986061,2
    --5598740(+) TCCCCA/GTTGCA 2 -- ut510--------
    rs1490846771,2
    --5598860(+) ACCACC/TGGTTC 2 -- ut510--------
    rs1169531941,2
    C,F--5599042(+) GAAACC/TGGTGG 2 -- ut511Minor allele frequency- T:0.01NA 120
    rs1431108421,2
    C--5599243(+) GGAGAC/GGAGGC 2 -- ut510--------
    rs1482244271,2
    --5599284(+) GCCATA/GGGGTG 2 -- ut510--------
    rs1852052301,2
    --5599323(+) TGAGGC/GTTCAA 2 -- ut510--------
    rs1923617451,2
    --5599378(+) CTGGTA/GGGCTG 2 -- ut510--------
    rs7787981,2
    C,F,O,A,H--5599430(+) CCTCAA/CCAAGC 2 -- ut5136Minor allele frequency- T:0.01EA NA NS WA CSA 2945
    rs1411893821,2
    --5599553(+) AATACC/TGGTTT 2 -- ut510--------
    rs37607761,2
    C,F,H--5599563(-) TCCTCC/TCTCAA 2 -- us2k1 tfbs328Minor allele frequency- T:0.21EA NA NS WA CSA 4384
    rs794844471,2
    F--5599605(+) TGCAAA/GGGTGA 2 -- us2k11Minor allele frequency- G:0.01NA 120
    rs1836786601,2
    --5599628(+) CCCAGA/CCTCCA 2 -- us2k10--------
    rs1123588261,2
    C,F--5599756(+) TGGGCC/TAGGGG 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1886783631,2
    --5599791(+) AGTGGC/TAACCT 2 -- us2k10--------
    rs169932281,2
    C,F,H--5599795(+) GCAACC/ATAATT 2 -- us2k118Minor allele frequency- A:0.04NA NS EA 1882
    rs1917827301,2
    --5600024(+) GTGGGC/TGCCTG 2 -- us2k10--------
    rs1828650491,2
    --5600034(+) GTAGTC/TCCAGC 2 -- us2k10--------
    rs7787991,2
    A--5600131(+) tgggcA/Gacagt 2 -- us2k10--------
    rs1378761991,2
    --5600251(+) CGCTTA/GAGCCC 2 -- us2k10--------
    rs7086861,2
    C,F,A,H--5600436(+) gactaC/Taggcg 2 -- us2k120Minor allele frequency- T:0.48NS EA NA WA CSA 2228
    rs7086851,2
    C,F,H--5600478(+) ttttaG/Atagag 2 -- us2k112Minor allele frequency- A:0.26WA NA CSA EA 376
    rs1159677291,2
    F--5600487(+) AGCTGG/TTTTTC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1871577581,2
    --5600673(+) TGGCAC/TGATCT 2 -- us2k10--------
    rs104097721,2
    C,F--5600747(+) ACAGGA/CGTCCG 2 -- us2k14Minor allele frequency- C:0.43WA CSA 7
    rs1463936971,2
    --5600762(+) CACGCC/TCAGCT 2 -- us2k10--------
    rs752433011,2
    C,F--5600977(+) GTCATT/CCCATC 2 -- us2k11Minor allele frequency- C:0.03EA 120
    rs1393875201,2
    C--5600992(+) TGATCA/GCTGGG 2 -- us2k10--------
    rs1915536011,2
    --5601054(+) AACGTA/GTGCTC 2 -- us2k10--------
    rs37607751,2
    C,F,H--5601177(-) TGATAC/ACCTAC 2 -- us2k129Minor allele frequency- A:0.23EA NS NA WA CSA 4362
    rs599933171,2
    C--5601269(+) GTTGGC/GGTCTT 2 -- us2k10--------
    rs37607741,2
    C,F,A,H--5601283(-) GTCCAA/GTGAGG 2 -- us2k124Minor allele frequency- G:0.32EA NS NA WA 3922
    rs37607731,2
    C,F--5601421(-) CAGCCC/AGTGGG 2 -- us2k11Minor allele frequency- A:0.00NA 2
    rs1874537291,2
    --5601479(+) TGGGGA/GTTTGA 2 -- us2k10--------
    rs1119125751,2
    C,F--5830599(+) CCACCG/ACACCC 2 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs1126412071,2
    C,F--5833621(+) CCAACG/ATGGTG 2 -- int12Minor allele frequency- A:0.50WA CSA 4
    rs113055481,2
    C--5834149(+) AAAAGA/-AAAAA 2 -- int1 trp32Minor allele frequency- -:0.25NA CSA 4
    rs1378586641,2
    C--5834251(+) GGACA-/GATAGGAGGGAGAAT
    AGGCAGGCGTGGGGACC
    GATAG
    2 -- int10--------
    rs58269051,2
    C--5834825(+) AAAAA-/ACAAAA 2 -- int10--------
    rs1128680501,2
    C--5836217(+) GTTAA-/TTTTC/T
    TTTCTTTTC
    TTTTC
    2 -- int11CSA 2
    rs1131850711,2
    C--5837732(+) AGGTCA/GCGCCA 2 -- int11Minor allele frequency- G:0.00CSA 1
    rs718360601,2
    C--5840335(+) GTCTC-/AAAAAAA 2 -- us2k10--------
    rs129729601,2
    C,A--5840789(+) GGGTTC/TTTTTT 2 -- us2k1 trp32Minor allele frequency- T:0.33WA CSA 3
    rs356284901,2
    ----5590645(+) ATTTT-/TAGTAG 2 -- ut310--------
    rs112671241,2
    ----5834282(+) GGGAC-/CGATAGGAGGGAGAA
    TAGGCAGGCGTGGGGAC
    TCACA
    2 -- int10--------
    rs718441111,2
    ----5840789(+) GGTTT-/CTTT  
            
    TTTTT
    2 -- us2k10--------
    rs783243821,2
    ----5597625(+) ATAAA-/ATAAA 
            
    TAAAC
    2 -- int10--------
    rs3679581741,2
    ----5592141(+) CTTGCA/GTCGGC 4 R C mis10--------
    rs1477990771,2
    ----5591566(+) AAGGCG/ATCGGG 4 /D syn11Minor allele frequency- A:0.00NA 3778
    rs600372611,2
    ----5593571(+) CACTTG/TAACCC 2 -- int10--------
    rs3766197461,2
    ----5600420(+) CCTCCC/TAGTAG 2 -- us2k10--------
    rs3684249211,2
    ----5594406(+) GACCGC/GTGAGG 2 -- int10--------
    rs1392959201,2
    ----5591370(+) TATGCC/TGCGTG 4 S G mis11Minor allele frequency- T:0.00NA 4544
    rs1477954651,2
    ----5591847(+) TGCCCA/GGGCCA 4 R W mis11Minor allele frequency- G:0.00NA 4532
    rs1420688941,2
    ----5592117(+) GACCGC/TGTCTG 4 T A mis11Minor allele frequency- T:0.00NA 4550
    rs3762898341,2
    ----5593216(+) GGTGGC/TGTGTG 2 -- int10--------
    rs3736614771,2
    ----5597147(+) AGGCAC/TGAGTC 2 -- int10--------
    rs3676128551,2
    ----5591532(+) GTCCTC/TGGGGC 4 K E mis10--------
    rs3733186741,2
    ----5594651(+) AAAAAA/CAAAAA 2 -- int10--------
    rs1995970751,2
    ----5592144(+) GCGGTC/TGGCAG 4 N D mis11Minor allele frequency- T:0.00EU 1323
    rs567720131,2
    ----5593572(+) ACTTGA/GACCCG 2 -- int10--------
    rs3711358831,2
    ----5597905(+) TATGGC/TACCTC 2 -- int10--------
    rs3727926191,2
    ----5590050(+) ACCACA/TGGCGC 2 -- ds50010--------
    rs342213391,2
    ----5596400(+) ACCTA-/ATAATC 2 -- int10--------
    rs3738160971,2
    ----5591547(+) GAAGTC/TGTCCA 4 N D mis10--------
    rs1447436911,2
    ----5592146(+) GGTCGG/ACAGTG 4 /A /V mis11Minor allele frequency- A:0.00NA 4548
    rs3721804341,2
    ----5590806(+) GGTGCA/GTGATT 2 -- ut310--------
    rs3752517231,2
    ----5590809(+) GCGGTC/GTTATC 2 -- ut310--------
    rs3718675521,2
    ----5592370(+) AGCAGC/TTGGTC 4 T syn10--------
    rs3749721541,2
    ----5597751(+) ACAGCC/TCTCGA 2 -- int10--------
    rs3687832401,2
    ----5600084(+) GAGGCA/GAGCTT 2 -- us2k10--------
    rs3774711951,2
    ----5592166(+) TCAGCC/TGTGCC 4 T syn10--------
    rs2007109041,2
    ----5592420(+) CAGGGG/AATCCA 4 /P /S mis11Minor allele frequency- A:0.00EU 1313
    rs3683650321,2
    ----5598719(+) CAAATC/TTGGGG 2 -- ut510--------
    rs1443987411,2
    ----5591807(+) AGTAGC/TGCACC 4 H R mis11Minor allele frequency- T:0.00NA 4550
    rs24347181,2
    ----5596044(+) CTTTTC/GTTTTC 2 -- int1 trp30--------
    rs3710110741,2
    ----5593254(+) GAGGCA/GGAGAA 2 -- int10--------
    rs352853661,2
    ----5594846(+) GGATC-/CTGGAG 2 -- int1 ut510--------
    rs3776823511,2
    ----5591952(+) GCTGCA/GTAGGA 4 R C mis10--------
    rs3713309191,2
    ----5600770(+) AGCTA-/TTTTTTT 2 -- us2k10--------
    rs3701911581,2
    ----5591623(+) GGCACA/GGCCCA 4 A syn10--------
    rs3766678831,2
    ----5591908(+) GACCAC/TGGCTC 4 P syn10--------
    rs3693258041,2
    ----5600450(-) AGTGCC/TGTGTC 2 -- us2k10--------
    rs621059611,2
    ----5595484(+) TAATGC/TCAGCT 2 -- int10--------
    rs3704373171,2
    ----5593337(+) AATTCC/TATCTT 2 -- int10--------
    rs3744067421,2
    ----5596269(+) GAACTC/TCTGAC 2 -- int10--------
    rs3736427271,2
    ----5591377(+) CGTGTC/TTGGTA 4 Q syn10--------
    rs3709734221,2
    ----5593273(+) AACCTA/GGGGGG 2 -- int10--------
    rs360911031,2
    ----5590075(+) CAGGG-/GAATTG 2 -- ds50010--------
    rs3675482371,2
    ----5593847(+) TTAGCC/TGGGCA 2 -- int10--------

    HapMap Linkage Disequilibrium report for FUT6 (5830621 - 5839742 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for FUT6:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718050CNV Deletion23290073
    dgv3694n71CNV Loss21882294
    dgv3693n71CNV Loss21882294
    nsv910901CNV Loss21882294
    nsv910903CNV Loss21882294


    Human Gene Mutation Database (HGMD): FUT6

    Locus Specific Mutation Databases (LSDB): FUT6
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FUT6
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 136836    OMIM disorders: --

    9 diseases for FUT6:    About MalaCards
    cytomegalovirus infection    herpes simplex    colorectal cancer    schizophrenia
    hepatocellular carcinoma    lung cancer    endotheliitis    pancreatitis
    breast cancer


    FUT6 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for FUT6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 35.9 3 12670495 (2), 10747292 (1)
    cancer lung 0 1 10449611 (1)
    colorectal cancer 0 1 9690558 (1)
    carcinoma 0 2 9690558 (2)
    cancer 0 3 7693344 (1), 9538143 (1), 10449611 (1)

    Genetic Association Database (GAD): FUT6
    Human Genome Epidemiology (HuGE) Navigator: FUT6 (4 documents)

    Export disorders for FUT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT6 gene, integrated from 9 sources (see all 72):
    (articles sorted by number of sources associating them with FUT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PubMed id 1520296)1, 2, 3, 9 Koszdin K.L. and Bowen B.R. (1992)
    2. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PubMed id 7650030)1, 2, 9 Cameron H.S.... Weston B.W. (1995)
    3. Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). (PubMed id 8175676)1, 2, 9 Mollicone R....Oriol R. (1994)
    4. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PubMed id 7782074)1, 3, 9 McCurley R.S....Weston B.W. (1995)
    5. Genome-wide association study identifies novel loci as sociated with serum level of vitamin B12 in Chinese men. (PubMed id 22367966)1, 4 Lin X....Sun J. (2012)
    6. Genomics meets glycomics-the first GWAS study of huma n N-Glycome identifies HNF1I+ as a master regulator of plasma protein fucosylati on. (PubMed id 21203500)1, 4 Lauc G....Rudan I. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. (PubMed id 1339443)1, 2 Weston B.W.... Lowe J.B. (1992)
    9. Identification of two functionally deficient plasma alpha 3-fucosyltransferase (FUT6) alleles. (PubMed id 11102976)2, 9 Elmgren A....Larson G. (2000)
    10. Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. (PubMed id 12670495)1, 9 Kanoh A....Irimura T. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2528 HGNC: 4017 AceView: FUT6 Ensembl:ENSG00000156413 euGenes: HUgn2528
    ECgene: FUT6 Kegg: 2528 H-InvDB: FUT6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT6
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_603

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FUT6 gene:
    Search GeneIP for patents involving FUT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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