Aliases for FUT6 Gene
Aliases for FUT6 Gene
External Ids for FUT6 Gene
- HGNC: 4017
- Entrez Gene: 2528
- Ensembl: ENSG00000156413
- OMIM: 136836
- UniProtKB: P51993
Previous GeneCards Identifiers for FUT6 Gene
- GC19M005922
- GC19M005771
- GC19M005781
- GC19M005759
- GC19M005590
Summaries for FUT6 Gene
-
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FUT6 Gene
FUT6 (Fucosyltransferase 6) is a Protein Coding gene. Diseases associated with FUT6 include Fucosyltransferase 6 Deficiency and Gastrointestinal Carcinoma. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT5.
UniProtKB/Swiss-Prot for FUT6 Gene
-
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT6 Gene
Genomics for FUT6 Gene
Regulatory Elements for FUT6 Gene
Enhancers for FUT6 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around FUT6 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the FUT6 gene promoter:
Regulatory Element Products
Genomic Location for FUT6 Gene
- Chromosome:
- 19
- Start:
- 5,830,610 bp from pter
- End:
- 5,839,753 bp from pter
- Size:
- 9,144 bases
- Orientation:
- Minus strand
Genomic View for FUT6 Gene
Genes around FUT6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC
FUT6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FUT6 Gene
Proteins for FUT6 Gene
-
Protein details for FUT6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51993-FUT6_HUMAN
- Recommended name:
- Alpha-(1,3)-fucosyltransferase 6
- Protein Accession:
- P51993
- A6NEX0
- D6W637
- Q9UND8
Protein attributes for FUT6 Gene
- Size:
- 359 amino acids
- Molecular mass:
- 41860 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for FUT6 Gene
Selected DME Specific Peptides for FUT6 Gene
- P51993:
-
- FYLAFENS
- HPPLNLSAKTELVAWAVSNW
- ALPRCSEM
- ITADRKVYPQAD
- SARVRYYQSL
- QGQRWIWF
- CFFSYLR
- PYGWLEPW
- VYPQADAVIVHH
- GTMMETLSRYKFYLAFENS
- VPVVLGP
- AHLKVDVYG
- RCSEMVPG
- DFQSPKDLA
- ADCNITA
- SIPLILLWTWPFNKP
- DYITEKLW
- FCKACWKLQ
- FIHVDDF
Post-translational modifications for FUT6 Gene
Other Protein References for FUT6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for FUT6
-
Custom Antibody ServicesOriGene Antibodies for FUT6
- Novus Biologicals Antibodies for FUT6
-
Cloud-Clone Corp. Antibodies for FUT6
- Invitrogen Antibodies for FUT6
- antibodies-online Antibodies for FUT6: See all 66
- Search GeneTex for Antibodies for FUT6
-
Custom Antibody ServicesProSci Antibodies for FUT6
Protein Products
-
OriGene Purified Proteins for FUT6
- Search Origene for MassSpec and Protein Over-expression Lysates for FUT6
- Origene Custom Protein Services for FUT6
-
Cloud-Clone Corp. Proteins for FUT6
- Search GeneTex for Proteins for FUT6
Domains & Families for FUT6 Gene
Gene Families for FUT6 Gene
Protein Domains for FUT6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FUT6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P51993- Family:
-
- Belongs to the glycosyltransferase 10 family.
Function for FUT6 Gene
Molecular function for FUT6 Gene
- GENATLAS Biochemistry:
- fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteins produced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with a FUT6 missense mutation,with a high allelic diversity,ethnic specific
- UniProtKB/Swiss-Prot CatalyticActivity:
- GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
- UniProtKB/Swiss-Prot Function:
- Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.
Enzyme Numbers (IUBMB) for FUT6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008417 | fucosyltransferase activity | TAS | 8175676 |
| GO:0016740 | transferase activity | IEA | -- |
| GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
| GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity | IEA | -- |
| GO:0046920 | alpha-(1->3)-fucosyltransferase activity | TAS | 11698403 |
Phenotypes for FUT6 Gene
- GenomeRNAi human phenotypes for FUT6:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for FUT6 gene
-
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- Search ViGene Biosciences for FUT6
CRISPR Products
-
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-
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miRNA for FUT6 Gene
- miRTarBase miRNAs that target FUT6
miRNA Products
- Search ViGene Biosciences for FUT6
Inhibitory RNA Products
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-
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for FUT6
-
ViGene Biosciences adenoviral particle packaged cDNA for FUT6 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for FUT6 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for FUT6 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUT6 Gene
Localization for FUT6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FUT6 Gene
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| golgi apparatus | 5 |
| peroxisome | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000139 | Golgi membrane | IBA | -- |
| GO:0005794 | Golgi apparatus | IDA,TAS | 11698403 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0032580 | Golgi cisterna membrane | IEA | -- |
Pathways & Interactions for FUT6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Glycosphingolipid biosynthesis - lacto and neolacto series | ||
| 2 | Metabolism | ||
Pathways by source for FUT6 Gene
2 KEGG pathways for FUT6 Gene
UniProtKB/Swiss-Prot P51993-FUT6_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for FUT6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006486 | protein glycosylation | TAS | 11698403 |
| GO:0036065 | fucosylation | IEA | -- |
| GO:0042355 | L-fucose catabolic process | NAS | 11698403 |
No data available for SIGNOR curated interactions for FUT6 Gene
Drugs & Compounds for FUT6 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Guanosine diphosphate | Experimental | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| GDP-L-fucose |
|
15839-70-0 |
|
Transcripts for FUT6 Gene
mRNA/cDNA for FUT6 Gene
- (14) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FUT6 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FUT6
-
Santa Cruz Biotechnology (SCBT) CRISPR for FUT6
- GenScript: Design CRISPR guide RNA sequences for FUT6
miRNA Products
- Search ViGene Biosciences for FUT6
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for FUT6
- Browse OriGene Inhibitory RNA Products For FUT6
-
ViGene Biosciences ready-to-package AAV shRNAs for FUT6 gene
Clone Products
- Sino Biological Human cDNA Clone for FUT6
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for FUT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FUT6
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||
| SP4: |
Expression for FUT6 Gene
mRNA differential expression in normal tissues according to GTEx for FUT6 Gene
This gene is overexpressed in Esophagus - Mucosa (x15.4), Kidney - Cortex (x10.0), Minor Salivary Gland (x7.4), Colon - Transverse (x4.8), and Vagina (x4.2).
This gene is overexpressed in Saliva (38.4), Oral epithelium (17.5), and Skin (7.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT6 Gene
NURSA nuclear receptor signaling pathways regulating expression of FUT6 Gene:
FUT6SOURCE GeneReport for Unigene cluster for FUT6 Gene:
Hs.631846mRNA Expression by UniProt/SwissProt for FUT6 Gene:
P51993-FUT6_HUMAN
Tissue specificity:
Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.
Evidence on tissue expression from TISSUES for FUT6 Gene
- Kidney(4.6)
- Nervous system(3.9)
- Liver(3.5)
- Intestine(2.6)
- Lung(2.2)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for FUT6
-
OriGene qPCR primer pairs and template standards for FUT6
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT6 Gene
Orthologs for FUT6 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FUT6 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | FUT5 34 35 35 |
|
||
| cow (Bos Taurus) |
Mammalia | FUT5 34 |
|
||
| -- 35 |
|
OneToMany | |||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| chicken (Gallus gallus) |
Aves | FUT5 34 |
|
||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
OneToMany | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495376 34 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | LOC399049 34 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003191 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | FucTA 36 34 |
|
- Species where no ortholog for FUT6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FUT6 Gene
(5) SIMAP similar genes for FUT6 Gene using alignment to 7 proteins:
Variants for FUT6 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for FUT6 Gene
- FUT6_HUMAN-P51993
- Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIM:613852].
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs17855739 | Pathogenic | 5,831,829(-) | CCTTC(A/G)AGAAC | reference, missense | |
| rs1000198565 | -- | 5,837,157(+) | CTCAG(A/C)CTCCC | intron-variant | |
| rs1000259809 | -- | 5,830,306(+) | TCTCT(-/CA)CACAC | downstream-variant-500B | |
| rs1000300084 | -- | 5,835,123(+) | CCTCA(A/G)CAGAG | intron-variant | |
| rs1000351901 | -- | 5,834,786(+) | CAGCA(C/G)AGTGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2718050 | CNV | deletion | 23290073 |
| esv3643541 | CNV | loss | 21293372 |
| esv3893160 | CNV | loss | 25118596 |
| nsv1062851 | CNV | gain | 25217958 |
Residual Variation Intolerance Score:
85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.36;
85.43% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for FUT6 Gene
Disorders for FUT6 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fucosyltransferase 6 deficiency |
|
|
| gastrointestinal carcinoma |
|
|
Search FUT6 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for FUT6
No data available for UniProtKB/Swiss-Prot and Genatlas for FUT6 Gene
Publications for FUT6 Gene
- The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PMID: 1520296) Koszdin K.L. … Bowen B.R. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 22 64
- Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley R.S. … Weston B.W. (Genomics 1995) 2 3 22 64
- Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron H.S. … Weston B.W. (J. Biol. Chem. 1995) 3 4 22 64
- Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). (PMID: 8175676) Mollicone R. … Oriol R. (J. Biol. Chem. 1994) 3 4 22 64
- Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PMID: 22367966) Lin X. … Sun J. (Hum. Mol. Genet. 2012) 3 46 64
Products for FUT6 Gene
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- antibodies-online Antibodies for FUT6: See all 66
- antibodies-online Kits for FUT6: See all 15
- Search antibodies-online for proteins
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- Search GeneTex for Antibodies for FUT6
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- ViGene Biosciences adenoviral particle packaged cDNA for FUT6 gene
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- Horizon Cell Lines for FUT6
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- VectorBuilder custom plasmid, inducible vectors for FUT6
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FUT6
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for FUT6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
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- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
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