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FUT6 Gene(Protein Coding)

Fucosyltransferase 6

GCID:
GC19M005830
GIFtS:
51
Genes Participants
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Aliases for FUT6 Gene

Aliases for FUT6 Gene

  • Fucosyltransferase 6 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 2 3 4
  • Fucosyltransferase VI 3 4
  • EC 2.4.1.65 4 56
  • Fuc-TVI 3 4
  • FucT-VI 3 4
  • FCT3A 3 4
  • Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase) 3
  • Alpha-(1,3)-Fucosyltransferase 6 3
  • Alpha-(1,3)-Fucosyltransferase 2
  • EC 2.4.1 56
  • FT1A 3

External Ids for FUT6 Gene

Previous GeneCards Identifiers for FUT6 Gene

  • GC19M005922
  • GC19M005771
  • GC19M005781
  • GC19M005759
  • GC19M005590

Summaries for FUT6 Gene

Entrez Gene Summary for FUT6 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT6 Gene

FUT6 (Fucosyltransferase 6) is a Protein Coding gene. Diseases associated with FUT6 include Fucosyltransferase 6 Deficiency and Gastrointestinal Carcinoma. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT5.

UniProtKB/Swiss-Prot for FUT6 Gene

  • Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

Gene Wiki entry for FUT6 Gene

Additional gene information for FUT6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT6 Gene

Genomics for FUT6 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for FUT6 Gene

Promoters and enhancers for FUT6 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I005837 Promoter/Enhancer 1.6 EPDnew ENCODE dbSUPER 550.8 +0.9 907 2.3 ELF3 MLX ZFP64 ARID4B THRB ZNF48 ZSCAN9 RAD21 RARA SCRT2 FUT6 DUS3L SNRPEP4 KHSRP NRTN ENSG00000269680 GC19M005817
GH19I005841 Enhancer 0.4 dbSUPER 550.8 -1.8 -1834 1.1 GLIS1 KDM1A ZIC2 FUT6 LOC101928844
GH19I005956 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -123.5 -123499 13.9 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 VMAC ENSG00000267571 CAPS DUS3L NDUFA11 GPR108 FUT5 ACSBG2 SAFB KDM4B
GH19I005913 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 11.1 -75.6 -75565 3.3 KLF1 MAZ RFX1 KLF17 ZIC2 RAD21 OSR2 ZFP69B GLIS2 ZNF692 CAPS ENSG00000267571 FUT3 FUT6 CATSPERD ENSG00000267314 GC19P005968 RANBP3
GH19I005803 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.8 +34.4 34442 3.4 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZNF213 E2F8 ZNF207 ZNF143 KLF13 NRTN DUS3L SAFB2 KHSRP GTF2F1 FUT6 FUT3 FUT5 NDUFA11 VMAC
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FUT6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUT6 gene promoter:

Genomic Locations for FUT6 Gene

Genomic Locations for FUT6 Gene
chr19:5,830,610-5,839,753
(GRCh38/hg38)
Size:
9,144 bases
Orientation:
Minus strand
chr19:5,830,621-5,839,742
(GRCh37/hg19)

Genomic View for FUT6 Gene

Genes around FUT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FUT6 Gene

Proteins for FUT6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FUT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51993-FUT6_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 6
    Protein Accession:
    P51993
    Secondary Accessions:
    • A6NEX0
    • D6W637
    • Q9UND8

    Protein attributes for FUT6 Gene

    Size:
    359 amino acids
    Molecular mass:
    41860 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for FUT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUT6 Gene

Protein Expression for FUT6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FUT6 Gene

P51993:
  • FYLAFENS
  • HPPLNLSAKTELVAWAVSNW
  • ALPRCSEM
  • ITADRKVYPQAD
  • SARVRYYQSL
  • QGQRWIWF
  • CFFSYLR
  • PYGWLEPW
  • VYPQADAVIVHH
  • GTMMETLSRYKFYLAFENS
  • VPVVLGP
  • AHLKVDVYG
  • RCSEMVPG
  • DFQSPKDLA
  • ADCNITA
  • SIPLILLWTWPFNKP
  • DYITEKLW
  • FCKACWKLQ
  • FIHVDDF

Post-translational modifications for FUT6 Gene

  • Glycosylation at isoforms=246, posLast=9191, posLast=153153, and posLast=184184

Other Protein References for FUT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT6 Gene

Gene Families for FUT6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FUT6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FUT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51993

UniProtKB/Swiss-Prot:

FUT6_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT6: view

Function for FUT6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for FUT6 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteins produced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with a FUT6 missense mutation,with a high allelic diversity,ethnic specific
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

Enzyme Numbers (IUBMB) for FUT6 Gene

Phenotypes From GWAS Catalog for FUT6 Gene

Gene Ontology (GO) - Molecular Function for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IDA 17604274
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT6: view
genes like me logo Genes that share phenotypes with FUT6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUT6 Gene

Localization for FUT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT6 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT6 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT6: view

Pathways & Interactions for FUT6 Gene

genes like me logo Genes that share pathways with FUT6: view

Pathways by source for FUT6 Gene

UniProtKB/Swiss-Prot P51993-FUT6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 11698403
GO:0006672 ceramide metabolic process IDA 17604274
GO:0036065 fucosylation IEA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT6: view

No data available for SIGNOR curated interactions for FUT6 Gene

Drugs & Compounds for FUT6 Gene

Products:

  1. Drug

(3) Drugs for FUT6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(4) Additional Compounds for FUT6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
 15839-70-0
genes like me logo Genes that share compounds with FUT6: view

Transcripts for FUT6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FUT6 Gene

(14) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT6 Gene

Fucosyltransferase 6 (alpha (1,3) fucosyltransferase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
SP1: -
SP2: - - - -
SP3: - - -
SP4:

Relevant External Links for FUT6 Gene

GeneLoc Exon Structure for
FUT6
ECgene alternative splicing isoforms for
FUT6

Expression for FUT6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT6 Gene

mRNA expression in normal human tissues for FUT6 Gene
mRNA expression by BioGPS for FUT6 GenemRNA expression by GTEx for FUT6 Gene

mRNA differential expression in normal tissues according to GTEx for FUT6 Gene

This gene is overexpressed in Esophagus - Mucosa (x15.4), Kidney - Cortex (x10.0), Minor Salivary Gland (x7.4), Colon - Transverse (x4.8), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for FUT6 Gene

This gene is overexpressed in Saliva (38.4), Oral epithelium (17.5), and Skin (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT6 Gene



Protein tissue co-expression partners for FUT6 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT6 Gene:

FUT6

SOURCE GeneReport for Unigene cluster for FUT6 Gene:

Hs.631846

mRNA Expression by UniProt/SwissProt for FUT6 Gene:

P51993-FUT6_HUMAN
Tissue specificity: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.

Evidence on tissue expression from TISSUES for FUT6 Gene

  • Kidney(4.6)
  • Nervous system(3.9)
  • Liver(3.5)
  • Intestine(2.6)
  • Lung(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with FUT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT6 Gene

Orthologs for FUT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia FUT6 33 34
  • 98.14 (n)
dog
(Canis familiaris)
 Mammalia FUT5 33 34 34
  • 78.08 (n)
cow
(Bos Taurus)
 Mammalia FUT5 33
  • 76.54 (n)
-- 34
  • 68 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 34
  • 55 (a)
 ManyToMany
-- 34
  • 49 (a)
 ManyToMany
-- 34
  • 46 (a)
 ManyToMany
oppossum
(Monodelphis domestica)
 Mammalia -- 34
  • 47 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves FUT5 33
  • 60.06 (n)
-- 34
  • 46 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 34
  • 49 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100495376 33
  • 52.86 (n)
African clawed frog
(Xenopus laevis)
 Amphibia LOC399049 33
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003191 33
  • 52.7 (n)
fruit fly
(Drosophila melanogaster)
 Insecta FucTA 35 33
  • 51.69 (n)
Species where no ortholog for FUT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT6 Gene

ENSEMBL:
Gene Tree for FUT6 (if available)
TreeFam:
Gene Tree for FUT6 (if available)

Paralogs for FUT6 Gene

Paralogs for FUT6 Gene

(5) SIMAP similar genes for FUT6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FUT6: view

Variants for FUT6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT6 Gene

FUT6_HUMAN-P51993
Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIM:613852].

Sequence variations from dbSNP and Humsavar for FUT6 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs145035679 benign, uncertain-significance, not provided, Fucosyltransferase 6 deficiency 5,831,623(-) G/T coding_sequence_variant, stop_gained
rs17855739 conflicting-interpretations-of-pathogenicity, Fucosyltransferase 6 deficiency 5,831,829(-) C/T coding_sequence_variant, missense_variant
rs1000198565 -- 5,837,157(-) C/A intron_variant
rs1000259809 -- 5,830,307(-) CACACACACACACA/CACACACACA/CACACACACACA/CACACACACACACACA downstream_transcript_variant
rs1000300084 -- 5,835,123(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FUT6 Gene

Variant ID Type Subtype PubMed ID
esv2718050 CNV deletion 23290073
esv3643541 CNV loss 21293372
esv3893160 CNV loss 25118596
nsv1062851 CNV gain 25217958

Variation tolerance for FUT6 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.36; 85.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUT6 Gene

Human Gene Mutation Database (HGMD)
FUT6
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT6

Disorders for FUT6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FUT6 Gene - From: HGMD, OMIM, GTR, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FUT6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUT6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FUT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT6 Gene

Publications for FUT6 Gene

  1. The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PMID: 1520296) Koszdin KL … Bowen BR (Biochemical and biophysical research communications 1992) 2 3 4 22 58
  2. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley RS … Weston BW (Genomics 1995) 2 3 22 58
  3. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron HS … Weston BW (The Journal of biological chemistry 1995) 3 4 22 58
  4. Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). (PMID: 8175676) Mollicone R … Oriol R (The Journal of biological chemistry 1994) 3 4 22 58
  5. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PMID: 22367966) Lin X … Sun J (Human molecular genetics 2012) 3 44 58

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