Aliases for FUT6 Gene
Aliases for FUT6 Gene
External Ids for FUT6 Gene
- HGNC: 4017
- Entrez Gene: 2528
- Ensembl: ENSG00000156413
- OMIM: 136836
- UniProtKB: P51993
Previous GeneCards Identifiers for FUT6 Gene
- GC19M005922
- GC19M005771
- GC19M005781
- GC19M005759
- GC19M005590
Summaries for FUT6 Gene
-
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FUT6 Gene
FUT6 (Fucosyltransferase 6) is a Protein Coding gene. Diseases associated with FUT6 include Fucosyltransferase 6 Deficiency and Gastrointestinal Carcinoma. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. Gene Ontology (GO) annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT5.
UniProtKB/Swiss-Prot for FUT6 Gene
-
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.
Additional gene information for FUT6 Gene
- Monarch Initiative
- Search for FUT6 at DataMed
- Search for FUT6 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT6 Gene
Genomics for FUT6 Gene
GeneHancer (GH) Regulatory Elements for FUT6 Gene
Regulatory Element Products
Genomic Locations for FUT6 Gene
- chr19:5,830,610-5,839,753
- (GRCh38/hg38)
- Size:
- 9,144 bases
- Orientation:
- Minus strand
- chr19:5,830,621-5,839,742
- (GRCh37/hg19)
Genomic View for FUT6 Gene
- Cytogenetic band:
-
- 19p13.3 by Ensembl
- 19p13.3 by Entrez Gene
- 19p13.3 by HGNC


RefSeq DNA sequence for FUT6 Gene
Proteins for FUT6 Gene
-
Protein details for FUT6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P51993-FUT6_HUMAN
- Recommended name:
- Alpha-(1,3)-fucosyltransferase 6
- Protein Accession:
- P51993
- A6NEX0
- D6W637
- Q9UND8
Protein attributes for FUT6 Gene
- Size:
- 359 amino acids
- Molecular mass:
- 41860 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
Protein Expression for FUT6 Gene
Selected DME Specific Peptides for FUT6 Gene
- P51993:
-
- FYLAFENS
- HPPLNLSAKTELVAWAVSNW
- ALPRCSEM
- ITADRKVYPQAD
- SARVRYYQSL
- QGQRWIWF
- CFFSYLR
- PYGWLEPW
- VYPQADAVIVHH
- GTMMETLSRYKFYLAFENS
- VPVVLGP
- AHLKVDVYG
- RCSEMVPG
- DFQSPKDLA
- ADCNITA
- SIPLILLWTWPFNKP
- DYITEKLW
- FCKACWKLQ
- FIHVDDF
Post-translational modifications for FUT6 Gene
- Glycosylation at isoforms=246, posLast=9191, posLast=153153, and posLast=184184
Other Protein References for FUT6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
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-
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Domains & Families for FUT6 Gene
Gene Families for FUT6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for FUT6 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FUT6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P51993- Family:
-
- Belongs to the glycosyltransferase 10 family.
Function for FUT6 Gene
Molecular function for FUT6 Gene
- GENATLAS Biochemistry:
- fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteins produced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with a FUT6 missense mutation,with a high allelic diversity,ethnic specific
- UniProtKB/Swiss-Prot CatalyticActivity:
- GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
- UniProtKB/Swiss-Prot Function:
- Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.
Enzyme Numbers (IUBMB) for FUT6 Gene
Phenotypes From GWAS Catalog for FUT6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0008417 | fucosyltransferase activity | IDA | 17604274 |
GO:0016740 | transferase activity | IEA | -- |
GO:0016757 | transferase activity, transferring glycosyl groups | IEA | -- |
GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity | IEA | -- |
GO:0046920 | alpha-(1->3)-fucosyltransferase activity | TAS | 11698403 |
Phenotypes for FUT6 Gene
- GenomeRNAi human phenotypes for FUT6:
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miRNA for FUT6 Gene
- miRTarBase miRNAs that target FUT6
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-
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- Mammalian expression: PiggyBac
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FUT6 gene related products
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-
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No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUT6 Gene
Localization for FUT6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FUT6 Gene
- Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
- Golgi apparatus (3)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IBA | -- |
GO:0005794 | Golgi apparatus | TAS | 11698403 |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0032580 | Golgi cisterna membrane | IEA | -- |
Pathways & Interactions for FUT6 Gene
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Glycosphingolipid biosynthesis - lacto and neolacto series | ||
2 | Metabolism |
Pathways by source for FUT6 Gene
2 KEGG pathways for FUT6 Gene
UniProtKB/Swiss-Prot P51993-FUT6_HUMAN
- Pathway: Protein modification; protein glycosylation.
Interacting Proteins for FUT6 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006486 | protein glycosylation | TAS | 11698403 |
GO:0006672 | ceramide metabolic process | IDA | 17604274 |
GO:0036065 | fucosylation | IEA | -- |
GO:0042355 | L-fucose catabolic process | NAS | 11698403 |
No data available for SIGNOR curated interactions for FUT6 Gene
Drugs & Compounds for FUT6 Gene
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine diphosphate | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
GDP-L-fucose |
|
15839-70-0 |
|
Transcripts for FUT6 Gene
mRNA/cDNA for FUT6 Gene
- (14) REFSEQ mRNAs :
- (14) Additional mRNA sequences :
- (22) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for FUT6 Gene
CRISPR Products
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FUT6
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miRNA Products
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Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- genomics-online: cdna clones - Search results for available FUT6 gene related products
- orf clones - Search results for available FUT6 gene related products
- Applied Biological Materials Clones for FUT6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||
SP4: |
Expression for FUT6 Gene
mRNA differential expression in normal tissues according to GTEx for FUT6 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT6 Gene
NURSA nuclear receptor signaling pathways regulating expression of FUT6 Gene:
FUT6SOURCE GeneReport for Unigene cluster for FUT6 Gene:
Hs.631846mRNA Expression by UniProt/SwissProt for FUT6 Gene:
P51993-FUT6_HUMANEvidence on tissue expression from TISSUES for FUT6 Gene
- Kidney(4.6)
- Nervous system(3.9)
- Liver(3.5)
- Intestine(2.6)
- Lung(2.2)
- Heart(2)
Primer Products
-
OriGene qPCR primer pairs for FUT6
-
OriGene qPCR primer pairs and template standards for FUT6
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No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT6 Gene
Orthologs for FUT6 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | FUT6 33 34 |
|
||
dog (Canis familiaris) |
Mammalia | FUT5 33 34 34 |
|
||
cow (Bos Taurus) |
Mammalia | FUT5 33 |
|
||
-- 34 |
|
OneToMany | |||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
ManyToMany | |
-- 34 |
|
ManyToMany | |||
-- 34 |
|
ManyToMany | |||
oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
chicken (Gallus gallus) |
Aves | FUT5 33 |
|
||
-- 34 |
|
OneToMany | |||
lizard (Anolis carolinensis) |
Reptilia | -- 34 |
|
OneToMany | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100495376 33 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | LOC399049 33 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003191 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | FucTA 35 33 |
|
- Species where no ortholog for FUT6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for FUT6 Gene
(5) SIMAP similar genes for FUT6 Gene using alignment to 7 proteins:
Variants for FUT6 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for FUT6 Gene
- FUT6_HUMAN-P51993
- Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIM:613852].
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs145035679 | benign, uncertain-significance, not provided, Fucosyltransferase 6 deficiency | 5,831,623(-) | G/T | coding_sequence_variant, stop_gained | |
rs17855739 | conflicting-interpretations-of-pathogenicity, Fucosyltransferase 6 deficiency | 5,831,829(-) | C/T | coding_sequence_variant, missense_variant | |
rs1000198565 | -- | 5,837,157(-) | C/A | intron_variant | |
rs1000259809 | -- | 5,830,307(-) | CACACACACACACA/CACACACACA/CACACACACACA/CACACACACACACACA | downstream_transcript_variant | |
rs1000300084 | -- | 5,835,123(-) | A/G | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2718050 | CNV | deletion | 23290073 |
esv3643541 | CNV | loss | 21293372 |
esv3893160 | CNV | loss | 25118596 |
nsv1062851 | CNV | gain | 25217958 |
Additional Variant Information for FUT6 Gene
Disorders for FUT6 Gene
Disorder | Aliases | PubMed IDs |
---|---|---|
fucosyltransferase 6 deficiency |
|
|
gastrointestinal carcinoma |
|
|
leukocyte adhesion deficiency, type i |
|
|
Additional Disease Information for FUT6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FUT6 Gene
Publications for FUT6 Gene
- The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PMID: 1520296) Koszdin KL … Bowen BR (Biochemical and biophysical research communications 1992) 2 3 4 22 58
- Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley RS … Weston BW (Genomics 1995) 2 3 22 58
- Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron HS … Weston BW (The Journal of biological chemistry 1995) 3 4 22 58
- Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). (PMID: 8175676) Mollicone R … Oriol R (The Journal of biological chemistry 1994) 3 4 22 58
- Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PMID: 22367966) Lin X … Sun J (Human molecular genetics 2012) 3 44 58
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- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 72 available FUT6 Antibodies ranked by validation data
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Sources for FUT6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
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