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FUT6 Gene(Protein Coding)

Fucosyltransferase 6

GCID:
GC19M005830
GIFtS:
61
Genes Participants
UDN Logo

Aliases for FUT6 Gene

Aliases for FUT6 Gene

  • Fucosyltransferase 6 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 2 3 4
  • Fucosyltransferase VI 3 4
  • EC 2.4.1.65 4 63
  • Fuc-TVI 3 4
  • FucT-VI 3 4
  • FCT3A 3 4
  • Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase) 3
  • Alpha-(1,3)-Fucosyltransferase 2
  • EC 2.4.1 63
  • FT1A 3

External Ids for FUT6 Gene

Previous GeneCards Identifiers for FUT6 Gene

  • GC19M005922
  • GC19M005771
  • GC19M005781
  • GC19M005759
  • GC19M005590

Summaries for FUT6 Gene

Entrez Gene Summary for FUT6 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT6 Gene

FUT6 (Fucosyltransferase 6) is a Protein Coding gene. Diseases associated with FUT6 include Fucosyltransferase 6 Deficiency and Gastrointestinal Carcinoma. Among its related pathways are Glycosphingolipid biosynthesis - lacto and neolacto series and Metabolism. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT4.

UniProtKB/Swiss-Prot for FUT6 Gene

  • Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

Gene Wiki entry for FUT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT6 Gene

Genomics for FUT6 Gene

Products:

  1. Regulatory Element

Regulatory Elements for FUT6 Gene

Enhancers for FUT6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FUT6 on UCSC Golden Path with GeneCards custom track

Promoters for FUT6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUT6 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the FUT6 gene promoter:

Genomic Location for FUT6 Gene

Chromosome:
19
Start:
5,830,610 bp from pter
End:
5,839,753 bp from pter
Size:
9,144 bases
Orientation:
Minus strand

Genomic View for FUT6 Gene

Genes around FUT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT6 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FUT6 Gene

Proteins for FUT6 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FUT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51993-FUT6_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 6
    Protein Accession:
    P51993
    Secondary Accessions:
    • A6NEX0
    • D6W637
    • Q9UND8

    Protein attributes for FUT6 Gene

    Size:
    359 amino acids
    Molecular mass:
    41860 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for FUT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUT6 Gene

Proteomics data for FUT6 Gene at MOPED

Protein Expression for FUT6 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for FUT6 Gene

P51993:

Post-translational modifications for FUT6 Gene

  • Glycosylation at Asn 46, Asn 91, Asn 153, and Asn 184
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for FUT6 Gene

Gene Families for FUT6 Gene

HGNC:

Protein Domains for FUT6 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FUT6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P51993

UniProtKB/Swiss-Prot:

FUT6_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT6: view

Function for FUT6 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for FUT6 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteins produced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with a FUT6 missense mutation,with a high allelic diversity,ethnic specific
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

Enzyme Numbers (IUBMB) for FUT6 Gene

Phenotypes for FUT6 Gene

GenomeRNAi human phenotypes for FUT6:
genes like me logo Genes that share phenotypes with FUT6: view

Animal Model Products

miRNA for FUT6 Gene

miRTarBase miRNAs that target FUT6

Inhibitory RNA Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUT6 Gene

Localization for FUT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT6 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT6 Gene COMPARTMENTS Subcellular localization image for FUT6 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
peroxisome 1

Gene Ontology (GO) - Cellular Components for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT6: view

Pathways & Interactions for FUT6 Gene

genes like me logo Genes that share pathways with FUT6: view

Pathways by source for FUT6 Gene

UniProtKB/Swiss-Prot P51993-FUT6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT6 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 15)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000286955%0d%0a9606.ENSP00000379353%0d%0a9606.ENSP00000377717%0d%0a9606.ENSP00000352144%0d%0a9606.ENSP00000309096%0d%0a9606.ENSP00000302599%0d%0a
Selected Interacting proteins: ENSP00000286955 for FUT6 Gene via STRING

Gene Ontology (GO) - Biological Process for FUT6 Gene

None

No data available for SIGNOR curated interactions for FUT6 Gene

Drugs & Compounds for FUT6 Gene

Products:

  1. Drug

(2) Drugs for FUT6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(5) Additional Compounds for FUT6 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
 15839-70-0
genes like me logo Genes that share compounds with FUT6: view

Transcripts for FUT6 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for FUT6 Gene

(16) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(12) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT6 Gene

Fucosyltransferase 6 (alpha (1,3) fucosyltransferase):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
SP1: -
SP2: - - - -
SP3: - - -
SP4:

Relevant External Links for FUT6 Gene

GeneLoc Exon Structure for
FUT6
ECgene alternative splicing isoforms for
FUT6

Expression for FUT6 Gene

Products:

  1. Primer

mRNA expression in normal human tissues for FUT6 Gene

mRNA expression in normal human tissues for FUT6 Gene
mRNA expression by BioGPS for FUT6 GenemRNA expression by GTEx for FUT6 Gene

mRNA differential expression in normal tissues according to GTEx for FUT6 Gene

This gene is overexpressed in Esophagus - Mucosa (x15.4), Kidney - Cortex (x10.0), Minor Salivary Gland (x7.4), Colon - Transverse (x4.8), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for FUT6 Gene

This gene is overexpressed in Saliva (38.4), Oral epithelium (17.5), and Skin (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT6 Gene



SOURCE GeneReport for Unigene cluster for FUT6 Gene Hs.631846

mRNA Expression by UniProt/SwissProt for FUT6 Gene

P51993-FUT6_HUMAN
Tissue specificity: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.
genes like me logo Genes that share expression patterns with FUT6: view

Protein tissue co-expression partners for FUT6 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FUT6 Gene

Orthologs for FUT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
 Mammalia FUT5 35
  • 76.54 (n)
  • 69.55 (a)
-- 36
  • 68 (a)
 OneToMany
dog
(Canis familiaris)
 Mammalia FUT5 35
  • 78.08 (n)
  • 73.33 (a)
FUT5 36
  • 68 (a)
 ManyToMany
FUT5 36
  • 67 (a)
 ManyToMany
chimpanzee
(Pan troglodytes)
 Mammalia FUT6 35
  • 98.14 (n)
  • 96.66 (a)
FUT6 36
  • 97 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 36
  • 47 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 36
  • 55 (a)
 ManyToMany
-- 36
  • 49 (a)
 ManyToMany
-- 36
  • 46 (a)
 ManyToMany
chicken
(Gallus gallus)
 Aves FUT5 35
  • 60.06 (n)
  • 52.19 (a)
-- 36
  • 46 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 36
  • 49 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100495376 35
  • 52.86 (n)
  • 51.78 (a)
African clawed frog
(Xenopus laevis)
 Amphibia LOC399049 35
fruit fly
(Drosophila melanogaster)
 Insecta FucTA 37
  • 36 (a)
FucTA 35
  • 51.69 (n)
  • 39.68 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003191 35
  • 52.7 (n)
  • 41.11 (a)
Species with no ortholog for FUT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT6 Gene

ENSEMBL:
Gene Tree for FUT6 (if available)
TreeFam:
Gene Tree for FUT6 (if available)

Paralogs for FUT6 Gene

Paralogs for FUT6 Gene

(5) SIMAP similar genes for FUT6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FUT6: view

Variants for FUT6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT6 Gene

FUT6_HUMAN-P51993
Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIM:613852].

Sequence variations from dbSNP and Humsavar for FUT6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs778805 - 5,832,198(-) GCTCC(C/T)CGAGG reference, missense
rs364637 - 5,831,880(-) TGCCC(A/C/T)AGGGA reference, missense, stop-gained
VAR_065915 -
rs17855739 - 5,831,829(-) CCTTC(A/G)AGAAC reference, missense
rs61147939 - 5,831,661(+) GTACC(A/C/G)GGCCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FUT6 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
dgv3694n71 CNV Loss 21882294
nsv910901 CNV Loss 21882294
nsv910903 CNV Loss 21882294
esv2718050 CNV Deletion 23290073

Variation tolerance for FUT6 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.36; 85.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT6 Gene

Human Gene Mutation Database (HGMD)
FUT6

Disorders for FUT6 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FUT6 Gene - From: OMIM, ClinVar, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fucosyltransferase 6 deficiency
gastrointestinal carcinoma
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FUT6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT6

Genetic Association Database (GAD)
FUT6
Human Genome Epidemiology (HuGE) Navigator
FUT6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT6
genes like me logo Genes that share disorders with FUT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT6 Gene

Publications for FUT6 Gene

  1. The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PMID: 1520296) Koszdin K.L. … Bowen B.R. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23 67
  2. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley R.S. … Weston B.W. (Genomics 1995) 2 3 23
  3. Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. (PMID: 12670495) Kanoh A. … Irimura T. (Biochem. Biophys. Res. Commun. 2003) 3 23
  4. alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles. (PMID: 10536043) Borsig L. … Berger E.G. (Glycobiology 1999) 3 23
  5. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron H.S. … Weston B.W. (J. Biol. Chem. 1995) 3 23

Products for FUT6 Gene

Sources for FUT6 Gene

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