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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT6 Gene

protein-coding   GIFtS: 60
GCID: GC19M005830

fucosyltransferase 6 (alpha (1,3) fucosyltransferase)

 Explore 13 diseases affiliated with
FUT6 via our new
 Human Malady Compendium 
Biological research products
for FUT6
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase)1 2     Fuc-TVI2 3
FCT3A1 2 3     EC 2.4.1.653 8
FucT-VI1 2 3     FLJ407541
FT1A1 2     Alpha-(1,3)-Fucosyltransferase1
Fucosyltransferase VI2 3     Fucosyltransferase 63
Galactoside 3-L-Fucosyltransferase2 3     EC 2.4.18

External Ids:    HGNC: 40171   Entrez Gene: 25282   Ensembl: ENSG000001564137   OMIM: 1368365   UniProtKB: P519933   

Export aliases for FUT6 gene to outside databases

Previous GC identifers: GC19M005922 GC19M005771 GC19M005781 GC19M005759 GC19M005590


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FUT6:
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X,
an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants
encoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
Function: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of
fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates

Gene Wiki entry for FUT6


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT6 gene promoter:
         c-Fos   HOXA9   HOXA9B   AP-1   C/EBPalpha   Meis-1b   Pax-3   CP2   c-Jun   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see first 1): FUT6 promoter sequences (S703626  S704604)
   Search SABiosciences Chromatin IP Primers for FUT6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FUT6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT6 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005830:  view genomic region     (about GC identifiers)

Start:
5,830,621 bp from pter      End:
5,839,742 bp from pter
Size:
9,122 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993 (See protein sequence)
Recommended Name: Alpha-(1,3)-fucosyltransferase  
Size: 359 amino acids; 41860 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound
form in trans cisternae of Golgi
Sequence caution: Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A6NEX0 D6W637 Q9UND8
Alternative splicing: 2 isoforms:  P51993-1   P51993-2   

Explore the universe of human proteins at neXtProt for FUT6: NX_P51993

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51993

  • 4/19 DME Specific Peptides for FUT6 (P51993) (see all 19)
     VPVVLGP  CFFSYLR  FIHVDDF  ADCNITA 

    FUT6 Protein expression data from MOPED and PaxDb:    About this image 
    FUT6 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000141.1  NP_001035791.1  

    ENSEMBL proteins: 
     ENSP00000431708   ENSP00000432954   ENSP00000286955   ENSP00000466016   ENSP00000436547  
     ENSP00000432161   ENSP00000436413   ENSP00000431880   ENSP00000433811   ENSP00000313398  

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    Uscn Proteins for FUT6

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS11698403
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    FUT6 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FUT6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001503 Glyco_trans_10

    Graphical View of Domain Structure for InterPro Entry P51993

    ProtoNet protein and cluster: P51993

    1 Blocks protein family: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
    Similarity: Belongs to the glycosyltransferase 10 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT6_HUMAN, P51993
    Function: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of
    fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates
    Catalytic activity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +
    beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R

         Genatlas biochemistry entry for FUT6:
    fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteins
    produced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with a
    FUT6 missense mutation,with a high allelic diversity,ethnic specific

         Enzyme Numbers (IUBMB): EC 2.4.1.651 2 EC 2.4.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008417fucosyltransferase activity TAS8175676
    GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA--
    GO:0046920alpha-(1->3)-fucosyltransferase activity TAS11698403
         
    FUT6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FUT6:
     Increased S DNA content 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series1.00
    2Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for FUT6):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
    Pathway: Protein modification; protein glycosylation


    FUT6 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for FUT6 (ENSP000002869554) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GNT2ENSP000003055954STRING: ENSP00000305595
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    B4GALT3ENSP000003209654STRING: ENSP00000320965
    FUT1ENSP000003120214STRING: ENSP00000312021
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation TAS11698403
    GO:0036065fucosylation TAS8175676
    GO:0042355L-fucose catabolic process NAS11698403

    FUT6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FUT6

    2 HMDB Compounds for FUT6    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    5 Novoseek chemical compound relationships for FUT6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slex 67.2 2 7630015 (1), 12725333 (1)
    polylactosamine 66.4 1 10622713 (1)
    n-acetyllactosamine 54.8 1 10891123 (1)
    n-ethylmaleimide 34.2 1 9042366 (1)
    n-acetylglucosamine 32 1 10052591 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT6 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FUT6 gene (2 alternative transcripts): 
    NM_000150.2  NM_001040701.1  

    Unigene Clusters for FUT6:

    Fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
    Hs.631846  [show with all ESTs], Hs.705615  [show with all ESTs]
    Unigene Representative Sequences: NM_000150, U27331
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000524754(uc021unl.1) ENST00000527106 ENST00000286955 ENST00000592563
    ENST00000529165 ENST00000531085 ENST00000531199 ENST00000532464 ENST00000528505
    ENST00000526499 ENST00000591079 ENST00000318336(uc002mdf.1 uc002mdg.1 uc002mdh.1)


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    Additional cDNA sequence: U27331.1 

    9 DOTS entries:

    DT.95243192  DT.86994016  DT.99952233  DT.100019203  DT.100750043  DT.75105001  DT.97777317  DT.99978277 
    DT.121449794 

    22 AceView cDNA sequences:

    U27332 U27331 BV198781 U27336 BX113350 AL702935 AW614132 M98825 
    BC061700 BM756773 AF131211 BV198591 AK098073 BG432556 AI672482 AI952786 
    AU098944 BG952128 BE833439 BG402446 AW176527 BV198613 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for FUT6    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
    SP1:              -                                                         
    SP2:              -           -     -     -                                 
    SP3:                          -     -     -                                 
    SP4:                                                                        


    ECgene alternative splicing isoforms for FUT6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATGGCACGTG
    FUT6 Expression
    About this image
    See FUT6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT6

    SOURCE GeneReport for Unigene clusters: Hs.631846 Hs.705615

    UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
    Tissue specificity: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUT6 gene from 6/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves F1NTW7_CHICK6
    Q8UWB9_CHICK6
    (see all 3)
    Uncharacterized protein
    fucosyltransferase 7 (alpha (1,3) fucosyltransfera...
    (see all 3)
    49(a)
    34(a)
    (see all 3)
    possible ortholog
    1 ↔ many
    (see all 3)
    28(1106979-1108076)
    17(838136-839179)
    lizard
    (Anolis carolinensis)
    Reptilia FUT106
    --
    14(a)
    possible ortholog
    GL343339.1(1146655-1163889)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3990492 alpha 1,3/4 fucosyltransferase Lewis 1 74.41(n)    AJ580005.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CT485993.16
    CABZ01086789.16
    --
    36(a)
    33(a)
    possible ortholog
    possible ortholog
    17(15480578-15481706)
    5(26911359-26912408)
    honey bee
    (Apis mellifera)
    Insecta --
    --
    21(a)
    possible ortholog
    Group1.53(187696-192664)
    worm
    (Caenorhabditis elegans)
    Secernentea fut-41 Protein FUT-4 42.45(n)
    32.53(a)
      187342  NM_061971.3  NP_494372.2 


    ENSEMBL Gene Tree for FUT6 (if available)
    TreeFam Gene Tree for FUT6 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT6 gene
    FUT52  FUT42  FUT72  FUT32  FUT102  FUT112  FUT92  
    5 SIMAP similar genes for FUT6 using alignment to 7 protein entries:     FUT6_HUMAN (see all proteins):
    FUT5    FUT3    FUT9    FUT7    FUT4

    FUT6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993
    Polymorphism: Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of
    individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma
    alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong
    linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma
    alpha(1,3)-fucosyltransferase deficiency [MIM:613852]


    10/268 NCBI SNPs in FUT6 are shown (see all 268    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs178557391,2
    C,Fpathogenic5591688(-) CCTTCG/AAGAAC 4 /K /E mis1 ese34Minor allele frequency- A:0.12NA EU 5867
    rs1119125751,2
    C,F--5590447(+) CCACCG/ACACCC 2 -- ds50012Minor allele frequency- A:0.50WA CSA 4
    rs7788061,2
    C,F,H--5590777(-) GCAAAG/AAAAAC 2 -- ut318Minor allele frequency- A:0.06NS EA WA 1208
    rs1167940361,2
    C,F--5591044(+) GTCCCC/TAGGAG 2 -- ut311Minor allele frequency- T:0.04WA 118
    rs4439071,2
    A--5591734(-) CAGGGA/GACCAT 4 G syn1 ese31Minor allele frequency- G:0.00NA 2
    rs3646371,2
    C,F,A,H--5591739(-) TGCCCC/AAGGGA 4 /K /Q mis1 ese310Minor allele frequency- A:0.09EA NA NS MN 5212
    rs39646311,2
    H--5591823(-) GGCCAA/GACTCC 4 N D mis14Minor allele frequency- G:0.00NS EA 414
    rs40414731,2
    H--5591824(-) GGGCCA/GAACTC 4 P syn14Minor allele frequency- G:0.00NS EA 420
    rs28794011,2
    --5591828(-) CTGGGA/GGCCAA 4 E G mis10--------
    rs1114943841,2
    F--5591900(+) GCTGGC/ACGGAC 4 /G /V mis11Minor allele frequency- A:0.50CSA 4

    HapMap Linkage Disequilibrium report for FUT6 (5830621 - 5839742 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FUT6: --
    Human Gene Mutation Database (HGMD): FUT6

    Locus Specific Mutation Databases (LSDB): FUT6

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FUT6 for disorders           About GeneDecksing

    OMIM gene information: 136836    OMIM disorders: --

    13 diseases for FUT6:    About MalaCards
    fucosyltransferase-6 deficiency    fucosyltransferase deficiency    cytomegalovirus infection    herpes simplex
    colon carcinoma    colorectal cancer    hepatocellular carcinoma    carcinoma
    lung carcinoma    lung cancer    breast cancer    schizophrenia
    pancreatitis

    5 Novoseek disease relationships for FUT6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 35.9 3 12670495 (2), 10747292 (1)
    cancer lung 0 1 10449611 (1)
    colorectal cancer 0 1 9690558 (1)
    carcinoma 0 2 9690558 (2)
    cancer 0 3 7693344 (1), 9538143 (1), 10449611 (1)

    Human Genome Epidemiology (HuGE) Navigator: FUT6 (4 documents)

    Export disorders for FUT6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT6 gene, integrated from 9 sources (see all 71):
    (articles sorted by number of sources associating them with FUT6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PubMed id 1520296)1, 2, 3, 9 Koszdin K.L. and Bowen B.R. (1992)
    2. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PubMed id 7650030)1, 2, 9 Cameron H.S.... Weston B.W. (1995)
    3. Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). (PubMed id 8175676)1, 2, 9 Mollicone R....Oriol R. (1994)
    4. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PubMed id 7782074)1, 3, 9 McCurley R.S....Weston B.W. (1995)
    5. Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. (PubMed id 1339443)1, 2 Weston B.W.... Lowe J.B. (1992)
    6. Identification of two functionally deficient plasma alpha 3-fucosyltransferase (FUT6) alleles. (PubMed id 11102976)2, 9 Elmgren A....Larson G. (2000)
    7. Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. (PubMed id 12670495)1, 9 Kanoh A....Irimura T. (2003)
    8. Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. (PubMed id 7656588)1, 9 Reguigne-Arnould I....Oriol R. (1995)
    9. alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles. (PubMed id 10536043)1, 9 Borsig L....Berger E.G. (1999)
    10. Functional analysis of a1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells. (PubMed id 22155250)1 Guo Q....Wu Y. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2528 HGNC: 4017 AceView: FUT6 Ensembl:ENSG00000156413 euGenes: HUgn2528
    ECgene: FUT6 Kegg: 2528 H-InvDB: FUT6

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT6 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT6
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_603

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FUT6 gene:
    Search GeneIP for patents involving FUT6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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