FUT6 Gene
protein-coding GIFtS: 60
GCID: GC19M005830
|
|
fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
| |
Aliases
for FUT6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase)1 2 | | Fuc-TVI2 3 | | FCT3A1 2 3 | | EC 2.4.1.653 8 | | FucT-VI1 2 3 | | FLJ407541 | | FT1A1 2 | | Alpha-(1,3)-Fucosyltransferase1 | | Fucosyltransferase VI2 3 | | Fucosyltransferase 63 | | Galactoside 3-L-Fucosyltransferase2 3 | | EC 2.4.18 |
Export aliases for FUT6 gene to outside databasesPrevious GC identifers: GC19M005922 GC19M005771 GC19M005781 GC19M005759 GC19M005590 |
Summaries
for FUT6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FUT6:
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X,an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variantsencoding the same protein have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993Function: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer offucose from GDP-beta-fucose to alpha-2,3 sialylated substrates
Gene Wiki entry for FUT6
|
Genomic Views
for FUT6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011255.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FUT6 gene promoter:
c-Fos HOXA9 HOXA9B AP-1 C/EBPalpha Meis-1b Pax-3 CP2 c-Jun Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FUT6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3FUT6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M005830: view genomic region
(about GC identifiers)
Start:
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5,830,621 bp from pter |
End:
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5,839,742 bp from pter |
Size:
|
9,122 bases |
Orientation:
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minus strand |
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Proteins
for FUT6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993 (See
protein sequence)Recommended Name: Alpha-(1,3)-fucosyltransferase Size: 359 amino acids; 41860 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-boundform in trans cisternae of Golgi
Sequence caution: Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A6NEX0 D6W637 Q9UND8Alternative splicing: 2 isoforms: P51993-1 P51993-2 Explore the universe of human proteins at neXtProt for FUT6: NX_P51993
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P51993
4/19 DME Specific Peptides for FUT6 (P51993) (see all 19)
FUT6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_000141.1 NP_001035791.1
ENSEMBL proteins: ENSP00000431708 ENSP00000432954 ENSP00000286955 ENSP00000466016 ENSP00000436547 ENSP00000432161 ENSP00000436413 ENSP00000431880 ENSP00000433811 ENSP00000313398
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
FUT6 for ontologies About GeneDecksing
FUT6 Antibody Products:
Assay Products for FUT6: |
Protein
Domains /
Families
for FUT6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FUT6 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P51993ProtoNet protein and cluster: P51993 1 Blocks protein family: IPB001503 Glycosyl transferase
UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993Similarity: Belongs to the glycosyltransferase 10 family |
Function
for FUT6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993Function: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer offucose from GDP-beta-fucose to alpha-2,3 sialylated substratesCatalytic activity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R Genatlas biochemistry entry for FUT6:fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteinsproduced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with aFUT6 missense mutation,with a high allelic diversity,ethnic specific
Enzyme Numbers (IUBMB): EC 2.4.1.651 2 EC 2.4.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUT6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUT6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FUT6 (NM_000150) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUT6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT6 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008417 | fucosyltransferase activity |
TAS | 8175676 | | GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity |
IEA | -- | | GO:0046920 | alpha-(1->3)-fucosyltransferase activity |
TAS | 11698403 |
FUT6 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FUT6:
|
Pathways & Interactions
for FUT6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Glycosphingolipid biosynthesis - lacto and neolacto series | | | 2 | Metabolism | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for FUT6):
UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993Pathway: Protein modification; protein glycosylation
FUT6 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/16 Interacting proteins for FUT6 (ENSP000002869554) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FUT6 for ontologies About GeneDecksing
|
Drugs & Compounds
for FUT6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FUT6 for compounds About GeneDecksing
 Browse Tocris compounds for FUT6
2 HMDB Compounds for FUT6 About this table
5 Novoseek chemical compound relationships for FUT6 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| slex |
67.2 |
2 |
7630015 (1), 12725333 (1) |
| polylactosamine |
66.4 |
1 |
10622713 (1) |
| n-acetyllactosamine |
54.8 |
1 |
10891123 (1) |
| n-ethylmaleimide |
34.2 |
1 |
9042366 (1) |
| n-acetylglucosamine |
32 |
1 |
10052591 (1) |
Search CenterWatch for drugs/clinical trials and news about FUT6
|
Transcripts
for FUT6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FUT6 gene (2 alternative transcripts): NM_000150.2 NM_001040701.1 Unigene Clusters for FUT6: Fucosyltransferase 6 (alpha (1,3) fucosyltransferase) Hs.631846 [show with all ESTs], Hs.705615 [show with all ESTs]Unigene Representative Sequences: NM_000150, U2733112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000524754(uc021unl.1) ENST00000527106 ENST00000286955 ENST00000592563
ENST00000529165 ENST00000531085 ENST00000531199 ENST00000532464 ENST00000528505
ENST00000526499 ENST00000591079 ENST00000318336(uc002mdf.1 uc002mdg.1 uc002mdh.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUT6 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUT6 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FUT6 (NM_000150) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUT6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT6 |
Additional cDNA sequence: U27331.1 9 DOTS entries: DT.95243192 DT.86994016 DT.99952233 DT.100019203 DT.100750043 DT.75105001 DT.97777317 DT.99978277 DT.121449794 22 AceView cDNA sequences: U27332 U27331 BV198781 U27336 BX113350 AL702935 AW614132 M98825 BC061700 BM756773 AF131211 BV198591 AK098073 BG432556 AI672482 AI952786 AU098944 BG952128 BE833439 BG402446 AW176527 BV198613
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for FUT6 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | ^ | 7 |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | - | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FUT6
|
Expression
for FUT6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FUT6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGCACGTG
About this image
See FUT6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FUT6
SOURCE GeneReport for Unigene clusters: Hs.631846 Hs.705615
UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993Tissue specificity: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland
SABiosciences Custom PCR Arrays for FUT6
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUT6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FUT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUT6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT6 |
Orthologs
for FUT6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FUT6 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for FUT6 (if available)
TreeFam Gene Tree for FUT6 (if available) |
Paralogs
for FUT6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FUT6 gene
- FUT52 FUT42 FUT72 FUT32 FUT102 FUT112 FUT92
5 SIMAP similar genes for FUT6 using alignment to 7 protein entries: FUT6_HUMAN (see all proteins):FUT5 FUT3 FUT9 FUT7 FUT4
FUT6 for paralogs About GeneDecksing
|
Genomic Variants
for FUT6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: FUT6_HUMAN, P51993Polymorphism: Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% ofindividuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasmaalpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting stronglinkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasmaalpha(1,3)-fucosyltransferase deficiency [MIM:613852]
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FUT6 (5830621 - 5839742 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FUT6: --
Human Gene Mutation Database (HGMD): FUT6
Locus Specific Mutation Databases (LSDB): FUT6
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUT6 |
|
Disorders
/ Diseases
for FUT6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FUT6 for disorders About GeneDecksing
OMIM gene information: 136836
OMIM disorders: --
13  diseases for FUT6: About MalaCardsfucosyltransferase-6 deficiency fucosyltransferase deficiency cytomegalovirus infection herpes simplex
colon carcinoma colorectal cancer hepatocellular carcinoma carcinoma
lung carcinoma lung cancer breast cancer schizophrenia
pancreatitis
5 Novoseek disease relationships for FUT6 gene About this table
Human Genome Epidemiology (HuGE) Navigator: FUT6 (4 documents)
Export disorders for FUT6 gene to outside databases
|
Publications
for FUT6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FUT6 gene integrated from 9 sources (see top 10):
(articles sorted by number of sources associating them with FUT6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PubMed id 1520296)1, 2, 3, 9 Koszdin K.L. and Bowen B.R. (1992)
- Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PubMed id 7650030)1, 2, 9 Cameron H.S.... Weston B.W. (1995)
- Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). (PubMed id 8175676)1, 2, 9 Mollicone R....Oriol R. (1994)
- Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PubMed id 7782074)1, 3, 9 McCurley R.S....Weston B.W. (1995)
- Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes. (PubMed id 1339443)1, 2 Weston B.W.... Lowe J.B. (1992)
- Identification of two functionally deficient plasma alpha 3-fucosyltransferase (FUT6) alleles. (PubMed id 11102976)2, 9 Elmgren A....Larson G. (2000)
- Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion. (PubMed id 12670495)1, 9 Kanoh A....Irimura T. (2003)
- Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. (PubMed id 7656588)1, 9 Reguigne-Arnould I....Oriol R. (1995)
- alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles. (PubMed id 10536043)1, 9 Borsig L....Berger E.G. (1999)
- Functional analysis of a1,3/4-fucosyltransferase VI in human hepatocellular carcinoma cells. (PubMed id 22155250)1 Guo Q....Wu Y. (2012)
- Genome-wide association study identifies novel loci as sociated with serum level of vitamin B12 in Chinese men. (PubMed id 22367966)1 Lin X....Sun J. (2012)
- The biosynthesis of the selectin-ligand sialyl Lewis x in colorectal cancer tissues is regulated by fucosyltransferase VI and can be inhibited by an RNA interference-based approach. (PubMed id 20965272)1 Trinchera M....Dall'olio F. (2011)
- Development of immunohistochemistry assays to assess GALNT14 and FUT3/6 in clinical trials of dulanermin and drozitumab. (PubMed id 20179215)1 Stern H.M....Ashkenazi A. (2010)
- Genomics meets glycomics-the first GWAS study of huma n N-Glycome identifies HNF1I+ as a master regulator of plasma protein fucosylati on. (PubMed id 21203500)1 Lauc G....Rudan I. (2010)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Activation of host antiviral RNA-sensing factors nece ssary for herpes simplex virus type 1-activated transcription of host cell fuco syltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) i n virus-infected cells. (PubMed id 19349624)1 NordAcn R....Olofsson S. (2009)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Transcriptional regulation of the fucosyltransferase VI gene in hepatocellular carcinoma cells. (PubMed id 18274891)1 Higai K....Matsumoto K. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene. (PubMed id 17054948)1 Higai K....Matsumoto K. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Activity and tissue distribution of splice variants of alpha6- fucosyltransferase in human embryogenesis. (PubMed id 14514715)1 Martinez-Duncker I.... Mollicone R. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. (PubMed id 11698403)1 Roos C.... Renkonen R. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase. (PubMed id 11530205)1 Kaminska J....Koscielak J. (2001)
- Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells. (PubMed id 10900002)1 Schnyder-Candrian S....Berger E.G. (2000)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
- Allelic diversity of the human plasma alpha(1,3)fucosyltransferase gene (FUT6). (PubMed id 10738539)9 Pang H....Kimura H. (1999)
- Molecular genetics of alpha-L-fucosyltransferase genes (H, Se, Le, FUT4, FUT5 and FUT6). (PubMed id 8019653)9 Mollicone R....Oriol R. (1994)
- Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations. (PubMed id 11404338)9 Koda Y....Kimura H. (2001)
- The gain-of-function Chinese hamster ovary mutant LEC11B expresses one of two Chinese hamster FUT6 genes due to the loss of a negative regulatory factor. (PubMed id 10187834)9 Zhang A....Stanley P. (1999)
- Detailed acceptor specificities of human alpha1,3-fucosyltransferases, Fuc-TVII and Fuc-TVI. (PubMed id 10211702)9 Shinoda K....Kiso M. (1998)
- A missense mutation in the FUT6 gene results in total absence of alpha3-fucosylation of human alpha1-acid glycoprotein. (PubMed id 8662894)9 Brinkman-Van der Linden E.C....Van Dijk W. (1996)
- In vitro alpha1-3 or alpha1-4 fucosylation of type I and II oligosaccharides with secreted forms of recombinant human fucosyltransferases III and VI. (PubMed id 10052591)9 Nimtz M....Conradt H.S. (1998)
- Identification of a new plasma alpha(1,3)fucosyltrans ferase (FUT6) allele requires an extended genotyping strategy. (PubMed id 8958648)9 Larson G....Oriol R. (1996)
- Up-regulation of Lewis enzyme (Fuc-TIII) and plasma-type alpha1,3fucosyltransferase (Fuc-TVI) expression determines the augmented expression of sialyl Lewis x antigen in non-small cell lung cancer. (PubMed id 10449611)9 Togayachi A....Narimatsu H. (1999)
- Human alpha-1,3 fucosyltransferase (FucT-VI) gene is located at only 13 kb 3' to the Lewis type fucosyltransferase (FucT-III) gene on chromosome 19. (PubMed id 7916594)9 Nishihara S....Narimatsu H. (1993)
- Structure/function study of Lewis alpha3- and alpha3/4-fucosyltransferases: the alpha1,4 fucosylation requires an aromatic residue in the acceptor-binding domain. (PubMed id 14718375)9 Dupuy F....Maftah A. (2004)
- Molecular analysis of plasma alpha 1,3-fucosyltransferase deficiency and development of the methods for its genotyping. (PubMed id 11150848)9 Tanaka S....Matta K.L. (2001)
- FUT4 and FUT9 genes are expressed early in human embryogenesis. (PubMed id 10929005)9 Cailleau-Thomas A.... Mennesson B. (2000)
- Complete genomic organization of futb encoding a bovine alpha 3-fucosyltransferase: exons in human orthologous genes emerged from ancestral intronic sequences. (PubMed id 10555285)9 Wierinckx A....Julien R. (1999)
- Gene expression of fucosyl- and sialyl-transferases which synthesize sialyl Lewisx, the carbohydrate ligands for E-selectin, in human breast cancer. (PubMed id 9538143)9 Matsuura N....Kannagi R. (1998)
- Up-regulation of a set of glycosyltransferase genes in human colorectal cancer. (PubMed id 9690558)9 Kudo T....Narimatsu H. (1998)
- Chemical modification of an alpha 3-fucosyltransferase; definition of amino acid residues essential for enzyme activity. (PubMed id 9042366)9 Britten C.J. and Bird M.I. (1997)
- Induction of sialyl-Lex expression by herpes simplex virus type 1 is dependent on viral immediate early RNA-activated transcription of host fucosyltransferase genes. (PubMed id 19369700)9 NystrAPm K....Olofsson S. (2009)
- Analysis of lewis antigens on cell surface and alpha1,3 fucosyltransferase subtypes in H7721 human hepatocarcinoma cells. (PubMed id 12725333)9 Guo P....Narimatsu H. (2003)
- Expression of sialyl 6-sulfo Lewis X is inversely correlated with conventional sialyl Lewis X expression in human colorectal cancer. (PubMed id 10728707)9 Izawa M....Kannagi R. (2000)
- The C-disaccharide alpha-C(1-->3)-mannopyranoside of N-acetylgalactosamine is an inhibitor of glycohydrolases and of human alpha-1,3-fucosyltransferase VI. Its epimer alpha-(1-->3)-mannopyranoside of N-acetyltalosamine is not. (PubMed id 10891123)9 Pasquarello C....Vogel P. (2000)
- Alpha1,3-L-fucosyltransferase expression in developing human myeloid cells. Antigenic, enzymatic, and mRNA analyses. (PubMed id 8626601)9 Clarke J.L. and Watkins W. (1996)
- Molecular genetics of H, Se, Lewis and other fucosyltransferase genes. (PubMed id 8542021)9 Mollicone R....Oriol R. (1995)
- Purification, properties and possible gene assignment of an alpha 1,3-fucosyltransferase expressed in human liver. (PubMed id 8748166)9 Johnson P.H....Watkins W.M. (1995)
- [Glycosyltransferase genes for synthesis of Lewis antigens] (PubMed id 7630015)9 Narimatsu H. (1995)
- Differential expression of alpha-2,3-sialyltransferas es and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a a nd sialyl Lewis x in gastrointestinal carcinoma cells. (PubMed id 19781661)9 Carvalho A.S....Reis C.A. (2010)
- Virus-induced transcriptional activation of host FUT genes associated with neo-expression of Ley in cytomegalovirus-infected and sialyl-Lex in varicella-zoster virus-infected diploid human cells. (PubMed id 17202152)9 Nystrom K....Olofsson S. (2007)
- Regulation of integrin functions by N-glycans. (PubMed id 15467392)9 Gu J. and Taniguchi N. (2004)
- Yeast cells harboring human alpha-1,3-fucosyltransferase at the cell surface engineered using Pir, a cell wall-anchored protein. (PubMed id 14734022)9 Abe H....Jigami Y. (2004)
- The polymorphisms of fucosyltransferases. (PubMed id 12935727)9 Koda Y....Kimura H. (2001)
- Production of soluble human alpha3-fucosyltransferase (FucT VII) by membrane targeting and in vivo proteolysis. (PubMed id 11555615)9 de Vries T....Bunschoten H. (2001)
- Transfection of alpha(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells. (PubMed id 10747292)9 Hiller K.M....Weston B.W. (2000)
- Divergent evolution of fucosyltransferase genes from vertebrates, invertebrates, and bacteria. (PubMed id 10089206)9 Oriol R....Breton C. (1999)
- Plasma alpha1,3-fucosyltransferase deficiency in schizophrenia. (PubMed id 10394050)9 Yazawa S....Kochibe N. (1999)
- Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. (PubMed id 10622713)9 Nishihara S....Narimatsu H. (1999)
- Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines. (PubMed id 9592127)9 Mas E....Sadoulet M.O. (1998)
- Distinct substrate specificities of five human alpha-1,3-fucosyltransferases for in vivo synthesis of the sialyl Lewis x and Lewis x epitopes. (PubMed id 9266844)9 Kimura H....Narimatsu H. (1997)
- Evolution of fucosyltransferase genes in vertebrates. (PubMed id 9368041)9 Costache M....Mollicone R. (1997)
- alpha-2,3-Sialyltransferase type 3N and alpha-1,3-fucosyltransferase type VII are related to sialyl Lewis(x) synthesis and patient survival from lung carcinoma. (PubMed id 9128982)9 Ogawa J.I....Koide S. (1997)
- Fucosyltransferase III and sialyl-Le(x) expression correlate in cultured colon carcinoma cells but not in colon carcinoma tissue. (PubMed id 8909999)9 Hanski C....Riecken E.O. (1996)
- Expression of alpha-1,3-fucosyltransferase type IV and VII genes is related to poor prognosis in lung cancer. (PubMed id 8542587)9 Ogawa J....Koide S. (1996)
- Human alpha(1,3/1,4)-fucosyltransferases discriminate between different oligosaccharide acceptor substrates through a discrete peptide fragment. (PubMed id 7673123)9 Legault D.J....Lowe J.B. (1995)
- Expression of alpha-(1,3)-fucosyltransferases which synthesize sialyl Le(x) and sialyl Le(a), the carbohydrate ligands for E- and P-selectins,in human malignant cell lines. (PubMed id 7693344)9 Yago K....Lowe J.B. (1993)
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External Searches for FUT6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing FUT6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing FUT6 gene
(According to HUGE)
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Specialized Databases showing FUT6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FUT6 | Pharmacogenomics, SNPs, Pathways | | GGDB | http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT6 | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_603 |
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About This Section
| Patent Information for FUT6 gene:
Search GeneIP for patents involving FUT6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FUT6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FUT6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUT6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUT6 | | | OriGene Protein Over-expression Lysate for FUT6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FUT6 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUT6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUT6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FUT6 | | OriGene Custom Protein Services for FUT6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FUT6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUT6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUT6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUT6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUT6 |
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| | | | Search Tocris compounds for FUT6 |
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 | | | FUT6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT6 |
|  |  |  | | | | ThermoFisher Antibody for FUT6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT6 |
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