Aliases for FUT6 Gene
External Ids for FUT6 Gene
Previous GeneCards Identifiers for FUT6 Gene
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FUT6 Gene
FUT6 (Fucosyltransferase 6) is a Protein Coding gene. Diseases associated with FUT6 include fucosyltransferase 6 deficiency and gastrointestinal carcinoma. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT4.
UniProtKB/Swiss-Prot for FUT6 Gene
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.