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Aliases for FUT6 Gene

Aliases for FUT6 Gene

  • Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase) 2 3
  • Galactoside 3-L-Fucosyltransferase 2 3 4
  • Fucosyltransferase VI 3 4
  • EC 2.4.1.65 4 63
  • Fuc-TVI 3 4
  • FucT-VI 3 4
  • FCT3A 3 4
  • Alpha-(1,3)-Fucosyltransferase 6 3
  • Alpha-(1,3)-Fucosyltransferase 2
  • Fucosyltransferase 6 4
  • EC 2.4.1 63
  • FT1A 3

External Ids for FUT6 Gene

Previous GeneCards Identifiers for FUT6 Gene

  • GC19M005922
  • GC19M005771
  • GC19M005781
  • GC19M005759
  • GC19M005590

Summaries for FUT6 Gene

Entrez Gene Summary for FUT6 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT6 Gene

FUT6 (Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase)) is a Protein Coding gene. Diseases associated with FUT6 include fucosyltransferase 6 deficiency and colorectal cancer. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT4.

UniProtKB/Swiss-Prot for FUT6 Gene

  • Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates

Gene Wiki entry for FUT6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT6 Gene

Genomics for FUT6 Gene

Regulatory Elements for FUT6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FUT6 Gene

Start:
5,830,610 bp from pter
End:
5,839,731 bp from pter
Size:
9,122 bases
Orientation:
Minus strand

Genomic View for FUT6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT6 Gene

Proteins for FUT6 Gene

  • Protein details for FUT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51993-FUT6_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 6
    Protein Accession:
    P51993
    Secondary Accessions:
    • A6NEX0
    • D6W637
    • Q9UND8

    Protein attributes for FUT6 Gene

    Size:
    359 amino acids
    Molecular mass:
    41860 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for FUT6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUT6 Gene

Proteomics data for FUT6 Gene at MOPED

Post-translational modifications for FUT6 Gene

  • Glycosylation at Asn46, Asn91, Asn153, and Asn184
  • Modification sites at PhosphoSitePlus

Domains for FUT6 Gene

Gene Families for FUT6 Gene

HGNC:
  • FUT :Fucosyltransferases

Protein Domains for FUT6 Gene

Suggested Antigen Peptide Sequences for FUT6 Gene

Graphical View of Domain Structure for InterPro Entry

P51993

UniProtKB/Swiss-Prot:

FUT6_HUMAN :
  • P51993
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT6: view

Function for FUT6 Gene

Molecular function for FUT6 Gene

GENATLAS Biochemistry: fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteins produced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with a FUT6 missense mutation,with a high allelic diversity,ethnic specific
UniProtKB/Swiss-Prot CatalyticActivity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R
UniProtKB/Swiss-Prot Function: Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates

Enzyme Numbers (IUBMB) for FUT6 Gene

Gene Ontology (GO) - Molecular Function for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 8175676
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT6: view

Phenotypes for FUT6 Gene

GenomeRNAi human phenotypes for FUT6:
genes like me logo Genes that share phenotypes with FUT6: view

Animal Model Products

CRISPR Products

miRNA for FUT6 Gene

miRTarBase miRNAs that target FUT6

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FUT6 Gene

Localization for FUT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT6 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT6 Gene COMPARTMENTS Subcellular localization image for FUT6 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with FUT6: view

Pathways for FUT6 Gene

genes like me logo Genes that share pathways with FUT6: view

Pathways by source for FUT6 Gene

UniProtKB/Swiss-Prot P51993-FUT6_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for FUT6 Gene

Gene Ontology (GO) - Biological Process for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation TAS 11698403
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT6: view

Compounds for FUT6 Gene

(2) HMDB Compounds for FUT6 Gene

Compound Synonyms Cas Number PubMed IDs
GDP-L-fucose
  • GDP-beta-L-fucose
15839-70-0
Guanosine diphosphate
  • 5'-GDP
146-91-8

(5) Novoseek inferred chemical compound relationships for FUT6 Gene

Compound -log(P) Hits PubMed IDs
slex 67.2 2
polylactosamine 66.4 1
n-acetyllactosamine 54.8 1
n-ethylmaleimide 34.2 1
n-acetylglucosamine 32 1
genes like me logo Genes that share compounds with FUT6: view

Transcripts for FUT6 Gene

Unigene Clusters for FUT6 Gene

Fucosyltransferase 6 (alpha (1,3) fucosyltransferase):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
SP1: -
SP2: - - - -
SP3: - - -
SP4:

Relevant External Links for FUT6 Gene

GeneLoc Exon Structure for
FUT6
ECgene alternative splicing isoforms for
FUT6

Expression for FUT6 Gene

mRNA expression in normal human tissues for FUT6 Gene

mRNA differential expression in normal tissues according to GTEx for FUT6 Gene

This gene is overexpressed in Esophagus - Mucosa (15.4), Kidney - Cortex (10.0), Minor Salivary Gland (7.4), Colon - Transverse (4.8), and Vagina (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FUT6 Gene

SOURCE GeneReport for Unigene cluster for FUT6 Gene Hs.631846

mRNA Expression by UniProt/SwissProt for FUT6 Gene

P51993-FUT6_HUMAN
Tissue specificity: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland
genes like me logo Genes that share expressions with FUT6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FUT6 Gene

Orthologs for FUT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT6 35
  • 98.14 (n)
  • 96.66 (a)
FUT6 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 68 (a)
OneToMany
FUT5 35
  • 76.54 (n)
  • 69.55 (a)
dog
(Canis familiaris)
Mammalia FUT5 35
  • 78.08 (n)
  • 73.33 (a)
FUT5 36
  • 68 (a)
ManyToMany
FUT5 36
  • 67 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 47 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 49 (a)
ManyToMany
-- 36
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 46 (a)
OneToMany
FUT5 35
  • 60.06 (n)
  • 52.19 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia LOC399049 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495376 35
  • 52.86 (n)
  • 51.78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003191 35
  • 52.7 (n)
  • 41.11 (a)
fruit fly
(Drosophila melanogaster)
Insecta FucTA 35
  • 51.69 (n)
  • 39.68 (a)
FucTA 37
  • 36 (a)
Species with no ortholog for FUT6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT6 Gene

ENSEMBL:
Gene Tree for FUT6 (if available)
TreeFam:
Gene Tree for FUT6 (if available)

Paralogs for FUT6 Gene

Paralogs for FUT6 Gene

Selected SIMAP similar genes for FUT6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FUT6: view

Variants for FUT6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT6 Gene

P51993-FUT6_HUMAN
Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIM:613852]

Sequence variations from dbSNP and Humsavar for FUT6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs364587 -- 5,831,926(-) CAGGC(C/T)CATCT reference, synonymous-codon
rs364637 - 5,831,880(-) TGCCC(A/C)AGGGA missense, reference
rs401508 -- 5,831,983(+) GACAC(C/T)GCCCA reference, synonymous-codon
rs443907 -- 5,831,875(-) CAGGG(A/G)ACCAT reference, synonymous-codon
rs445878 -- 5,831,959(+) CTGGC(A/C/G/T)GAGTT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for FUT6 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
dgv3694n71 CNV Loss 21882294
nsv910901 CNV Loss 21882294
nsv910903 CNV Loss 21882294
esv2718050 CNV Deletion 23290073

Relevant External Links for FUT6 Gene

HapMap Linkage Disequilibrium report
FUT6
Human Gene Mutation Database (HGMD)
FUT6
Locus Specific Mutation Databases (LSDB)
FUT6

Disorders for FUT6 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for FUT6 Gene including...

Search for FUT6 Gene in MalaCards »

(1) OMIM Diseases for FUT6 Gene (136836)

(5) Novoseek inferred disease relationships for FUT6 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 35.9 3
cancer lung 0 1
colorectal cancer 0 1
carcinoma 0 2
cancer 0 3

Relevant External Links for FUT6

Genetic Association Database (GAD)
FUT6
Human Genome Epidemiology (HuGE) Navigator
FUT6
genes like me logo Genes that share disorders with FUT6: view

No data available for UniProtKB/Swiss-Prot for FUT6 Gene

Publications for FUT6 Gene

  1. The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PMID: 1520296) Koszdin K.L. … Bowen B.R. (Biochem. Biophys. Res. Commun. 1992) 2 3 4 23
  2. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley R.S. … Weston B.W. (Genomics 1995) 2 3 23
  3. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron H.S. … Weston B.W. (J. Biol. Chem. 1995) 3 4 23
  4. Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). (PMID: 8175676) Mollicone R. … Oriol R. (J. Biol. Chem. 1994) 3 4 23
  5. Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19. (PMID: 7656588) Reguigne-Arnould I. … Oriol R. (Cytogenet. Cell Genet. 1995) 3 23

Products for FUT6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FUT6
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT6
  • Block miRNA regulation of FUT6 using miScript Target Protectors

Sources for FUT6 Gene

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