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Aliases for FUT6 Gene

Aliases for FUT6 Gene

  • Fucosyltransferase 6 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 2 3 4
  • Fucosyltransferase VI 3 4
  • EC 4 58
  • Fuc-TVI 3 4
  • FucT-VI 3 4
  • FCT3A 3 4
  • Fucosyltransferase 6 (Alpha (1,3) Fucosyltransferase) 3
  • Alpha-(1,3)-Fucosyltransferase 6 3
  • Alpha-(1,3)-Fucosyltransferase 2
  • EC 2.4.1 58
  • FT1A 3

External Ids for FUT6 Gene

Previous GeneCards Identifiers for FUT6 Gene

  • GC19M005922
  • GC19M005771
  • GC19M005781
  • GC19M005759
  • GC19M005590

Summaries for FUT6 Gene

Entrez Gene Summary for FUT6 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of sialyl-Lewis X, an E-selectin ligand. Mutations in this gene are a cause of fucosyltransferase-6 deficiency. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT6 Gene

FUT6 (Fucosyltransferase 6) is a Protein Coding gene. Diseases associated with FUT6 include Fucosyltransferase 6 Deficiency and Gastrointestinal Carcinoma. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT5.

UniProtKB/Swiss-Prot for FUT6 Gene

  • Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

Gene Wiki entry for FUT6 Gene

Additional gene information for FUT6 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT6 Gene

Genomics for FUT6 Gene

Regulatory Elements for FUT6 Gene

Enhancers for FUT6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H005956 1.9 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -123.5 -123500 13.9 PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B FEZF1 DMAP1 YY1 SLC30A9 VMAC CAPS NDUFA11 FUT5 ACSBG2 ENSG00000267571 GPR108 DUS3L FUT3 FUT6
GH19H005945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.9 -111.3 -111305 10.3 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF766 ZNF143 SP5 NDUFA11 CAPS FUT5 VMAC ACSBG2 FUT3 FUT6 SAFB2 GC19P005968 ENSG00000267571
GH19H005803 1.6 Ensembl ENCODE dbSUPER 11.8 +34.4 34442 3.4 ARID4B DMAP1 ZNF2 ZNF143 ZNF207 SP3 SP5 MXD4 REST ZNF592 DUS3L SAFB2 KHSRP GTF2F1 RANBP3 SAFB FUT6 FUT3 FUT5 NDUFA11
GH19H005913 1.2 Ensembl ENCODE dbSUPER 11.1 -75.6 -75566 3.3 MAZ KLF1 RFX1 KLF17 RAD21 ZIC2 OSR2 ZFP69B GLIS2 POLR2A CAPS FUT3 FUT6 CATSPERD ENSG00000267571 GC19P005968
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FUT6 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FUT6 Gene

Genomic Locations for FUT6 Gene
9,144 bases
Minus strand

Genomic View for FUT6 Gene

Genes around FUT6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT6 Gene

Proteins for FUT6 Gene

  • Protein details for FUT6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 6
    Protein Accession:
    Secondary Accessions:
    • A6NEX0
    • D6W637
    • Q9UND8

    Protein attributes for FUT6 Gene

    359 amino acids
    Molecular mass:
    41860 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC50191.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for FUT6 Gene


neXtProt entry for FUT6 Gene

Selected DME Specific Peptides for FUT6 Gene


Post-translational modifications for FUT6 Gene

  • Glycosylation at posLast=4646, isoforms=291, posLast=153153, and isoforms=2184
  • Modification sites at PhosphoSitePlus

Domains & Families for FUT6 Gene

Gene Families for FUT6 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for FUT6 Gene

Suggested Antigen Peptide Sequences for FUT6 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyltransferase 10 family.
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT6: view

Function for FUT6 Gene

Molecular function for FUT6 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),6 (FucT-VI),plasma type,responsible for the alpha 3-fucosylation of glycoproteins produced in liver as suggested by the total absence of alpha 3 fucosylated-alpha 1-glycoproteins in patients with a FUT6 missense mutation,with a high allelic diversity,ethnic specific
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
Enzyme involved in the biosynthesis of the E-Selectin ligand, sialyl-Lewis X. Catalyzes the transfer of fucose from GDP-beta-fucose to alpha-2,3 sialylated substrates.

Enzyme Numbers (IUBMB) for FUT6 Gene

Phenotypes From GWAS Catalog for FUT6 Gene

Gene Ontology (GO) - Molecular Function for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity IDA 17604274
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT6: view
genes like me logo Genes that share phenotypes with FUT6: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUT6 Gene

Localization for FUT6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT6 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT6 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT6: view

Pathways & Interactions for FUT6 Gene

genes like me logo Genes that share pathways with FUT6: view

Pathways by source for FUT6 Gene

UniProtKB/Swiss-Prot P51993-FUT6_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation TAS 11698403
GO:0006672 ceramide metabolic process IDA 17604274
GO:0036065 fucosylation IEA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT6: view

No data available for SIGNOR curated interactions for FUT6 Gene

Drugs & Compounds for FUT6 Gene

(3) Drugs for FUT6 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(4) Additional Compounds for FUT6 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
genes like me logo Genes that share compounds with FUT6: view

Transcripts for FUT6 Gene

Unigene Clusters for FUT6 Gene

Fucosyltransferase 6 (alpha (1,3) fucosyltransferase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT6 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7
SP1: -
SP2: - - - -
SP3: - - -

Relevant External Links for FUT6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUT6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT6 Gene

mRNA differential expression in normal tissues according to GTEx for FUT6 Gene

This gene is overexpressed in Esophagus - Mucosa (x15.4), Kidney - Cortex (x10.0), Minor Salivary Gland (x7.4), Colon - Transverse (x4.8), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for FUT6 Gene

This gene is overexpressed in Saliva (38.4), Oral epithelium (17.5), and Skin (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT6 Gene

Protein tissue co-expression partners for FUT6 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT6 Gene:


SOURCE GeneReport for Unigene cluster for FUT6 Gene:


mRNA Expression by UniProt/SwissProt for FUT6 Gene:

Tissue specificity: Kidney, liver, colon, small intestine, bladder, uterus and salivary gland.

Evidence on tissue expression from TISSUES for FUT6 Gene

  • Kidney(4.6)
  • Nervous system(3.9)
  • Liver(3.5)
  • Intestine(2.6)
  • Lung(2.2)
  • Heart(2)
genes like me logo Genes that share expression patterns with FUT6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT6 Gene

Orthologs for FUT6 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FUT6 33 34
  • 98.14 (n)
(Canis familiaris)
Mammalia FUT5 33 34 34
  • 78.08 (n)
(Bos Taurus)
Mammalia FUT5 33
  • 76.54 (n)
-- 34
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
-- 34
  • 49 (a)
-- 34
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 47 (a)
(Gallus gallus)
Aves FUT5 33
  • 60.06 (n)
-- 34
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100495376 33
  • 52.86 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC399049 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003191 33
  • 52.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta FucTA 35 33
  • 51.69 (n)
Species where no ortholog for FUT6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT6 Gene

Gene Tree for FUT6 (if available)
Gene Tree for FUT6 (if available)

Paralogs for FUT6 Gene

Paralogs for FUT6 Gene

(5) SIMAP similar genes for FUT6 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with FUT6: view

Variants for FUT6 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT6 Gene

Expression of alpha(1,3)-fucosyltransferase in plasma can vary among different populations. 9% of individuals on the isle of Java (Indonesia) do not express this enzyme. Ninety-five percent of plasma alpha(1,3)-fucosyltransferase-deficient individuals have Lewis negative phenotype on red cells, suggesting strong linkage disequilibrium between these two traits. Variations in FUT6 are responsible for plasma alpha(1,3)-fucosyltransferase deficiency [MIM:613852].

Sequence variations from dbSNP and Humsavar for FUT6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17855739 Pathogenic 5,831,829(-) CCTTC(A/G)AGAAC reference, missense
rs1000198565 -- 5,837,157(+) CTCAG(A/C)CTCCC intron-variant
rs1000259809 -- 5,830,306(+) TCTCT(-/CA)CACAC downstream-variant-500B
rs1000300084 -- 5,835,123(+) CCTCA(A/G)CAGAG intron-variant
rs1000351901 -- 5,834,786(+) CAGCA(C/G)AGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUT6 Gene

Variant ID Type Subtype PubMed ID
nsv1062851 CNV gain 25217958
esv3893160 CNV loss 25118596
esv3643541 CNV loss 21293372
esv2718050 CNV deletion 23290073

Variation tolerance for FUT6 Gene

Residual Variation Intolerance Score: 85.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.36; 85.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT6 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for FUT6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FUT6 Gene - From: HGMD, OMIM, DISEASES, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search FUT6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT6

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FUT6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT6 Gene

Publications for FUT6 Gene

  1. The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand. (PMID: 1520296) Koszdin KL … Bowen BR (Biochemical and biophysical research communications 1992) 2 3 4 22 60
  2. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley RS … Weston BW (Genomics 1995) 2 3 22 60
  3. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron HS … Weston BW (The Journal of biological chemistry 1995) 3 4 22 60
  4. Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6). (PMID: 8175676) Mollicone R … Oriol R (The Journal of biological chemistry 1994) 3 4 22 60
  5. Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men. (PMID: 22367966) Lin X … Sun J (Human molecular genetics 2012) 3 45 60

Products for FUT6 Gene

Sources for FUT6 Gene

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