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Aliases for FUT5 Gene

Aliases for FUT5 Gene

  • Fucosyltransferase 5 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Alpha (1,3) Fucosyltransferase 2 3
  • Fucosyltransferase V 3 4
  • EC 2.4.1.65 4 61
  • FUC-TV 3 4
  • FucT-V 3 4
  • Alpha-(1,3)-Fucosyltransferase 5 3
  • EC 2.4.1 61

External Ids for FUT5 Gene

Previous GeneCards Identifiers for FUT5 Gene

  • GC19M005957
  • GC19M005805
  • GC19M005816
  • GC19M005625

Summaries for FUT5 Gene

GeneCards Summary for FUT5 Gene

FUT5 (Fucosyltransferase 5) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT3.

UniProtKB/Swiss-Prot for FUT5 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

Gene Wiki entry for FUT5 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT5 Gene

Genomics for FUT5 Gene

Regulatory Elements for FUT5 Gene

Enhancers for FUT5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G005956 1.9 FANTOM5 Ensembl ENCODE dbSUPER 19.5 -92.7 -92713 13.9 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 SIN3A ARID4B DMAP1 FEZF1 VMAC CAPS NDUFA11 FUT5 ACSBG2 ENSG00000267571 GPR108 FUT3 FUT6 SLC25A41
GH19G005945 1.9 FANTOM5 Ensembl ENCODE dbSUPER 15 -80.5 -80518 10.3 FOXA2 PKNOX1 MLX SIN3A ARID4B DMAP1 YY1 SLC30A9 ZNF766 ZNF143 NDUFA11 CAPS FUT5 VMAC ACSBG2 FUT3 FUT6 SAFB2 GC19P005968 ENSG00000267571
GH19G005826 1.7 Ensembl ENCODE dbSUPER 11.1 +42.4 42402 3.7 CREB3L1 MLX AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 SP3 NFYC VMAC ENSG00000267571 NDUFA11 GPR108 SAFB SNRPEP4 DUS3L PRR22 CATSPERD FUT5
GH19G005803 1.6 Ensembl ENCODE dbSUPER 11.3 +65.2 65229 3.4 HDGF FOXA2 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 DUS3L SAFB2 GTF2F1 SAFB SNRPEP4 FUT6 FUT3 FUT5 NDUFA11 VMAC
GH19G005798 1.3 ENCODE dbSUPER 11.5 +71.1 71135 0.9 HDGF ATF1 CREB3L1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 CBX5 DUS3L CATSPERD LONP1 FUT6 FUT3 FUT5 NDUFA11 VMAC NRTN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FUT5 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUT5 Gene

Chromosome:
19
Start:
5,865,826 bp from pter
End:
5,870,540 bp from pter
Size:
4,715 bases
Orientation:
Minus strand

Genomic View for FUT5 Gene

Genes around FUT5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT5 Gene

Proteins for FUT5 Gene

  • Protein details for FUT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11128-FUT5_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 5
    Protein Accession:
    Q11128
    Secondary Accessions:
    • A8K4X2

    Protein attributes for FUT5 Gene

    Size:
    374 amino acids
    Molecular mass:
    43008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT5 Gene

Selected DME Specific Peptides for FUT5 Gene

Q11128:
  • APNGSRCQDS
  • FYLAFENS
  • HPPLNLSAKTELVAWAVSNW
  • ALPRCSEM
  • SARVRYYQSL
  • QGQRWIWF
  • CFFSYLR
  • VIVHHWDIM
  • PYGWLEPW
  • VYPQADAVIVHH
  • GTMMETLSRYKFYLAFENS
  • VPVVLGP
  • AHLKVDVYG
  • RCSEMVPG
  • DFQSPKDLA
  • ADCNITA
  • DYITEKLW
  • FCKACWKLQ
  • WFSMESPSNC
  • FIHVDDF

Post-translational modifications for FUT5 Gene

  • Glycosylation at isoforms=60, isoforms=105, Asn167, and isoforms=198
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT5 Gene

Gene Families for FUT5 Gene

Protein Domains for FUT5 Gene

Suggested Antigen Peptide Sequences for FUT5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q11128

UniProtKB/Swiss-Prot:

FUT5_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT5: view

Function for FUT5 Gene

Molecular function for FUT5 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),5 (FucT-V),plasma
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.

Enzyme Numbers (IUBMB) for FUT5 Gene

Gene Ontology (GO) - Molecular Function for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 1339443
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT5: view
genes like me logo Genes that share phenotypes with FUT5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUT5 Gene

Localization for FUT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT5 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT5 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT5: view

Pathways & Interactions for FUT5 Gene

genes like me logo Genes that share pathways with FUT5: view

Pathways by source for FUT5 Gene

UniProtKB/Swiss-Prot Q11128-FUT5_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 1339443
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation IEA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT5: view

No data available for SIGNOR curated interactions for FUT5 Gene

Drugs & Compounds for FUT5 Gene

(1) Drugs for FUT5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for FUT5 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT5: view

Transcripts for FUT5 Gene

mRNA/cDNA for FUT5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT5 Gene

Fucosyltransferase 5 (alpha (1,3) fucosyltransferase):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT5 Gene

No ASD Table

Relevant External Links for FUT5 Gene

GeneLoc Exon Structure for
FUT5
ECgene alternative splicing isoforms for
FUT5

Expression for FUT5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT5 Gene

Protein differential expression in normal tissues from HIPED for FUT5 Gene

This gene is overexpressed in Saliva (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUT5 Gene



Protein tissue co-expression partners for FUT5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT5 Gene:

FUT5

SOURCE GeneReport for Unigene cluster for FUT5 Gene:

Hs.631843

mRNA Expression by UniProt/SwissProt for FUT5 Gene:

Q11128-FUT5_HUMAN
Tissue specificity: Liver, colon and testis and trace amounts in T-cells and brain.

Evidence on tissue expression from TISSUES for FUT5 Gene

  • Kidney(4.3)
  • Blood(4.2)
  • Intestine(4.2)
  • Liver(4)
genes like me logo Genes that share expression patterns with FUT5: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT5 Gene

Orthologs for FUT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT5 34 35
  • 98.31 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FUT5 35 35
  • 67 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 55 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 46 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 35
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000365 34
  • 52.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta FucTA 36
  • 35 (a)
FucTC 36 34
  • 26 (n)
Species where no ortholog for FUT5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT5 Gene

ENSEMBL:
Gene Tree for FUT5 (if available)
TreeFam:
Gene Tree for FUT5 (if available)

Paralogs for FUT5 Gene

Paralogs for FUT5 Gene

(5) SIMAP similar genes for FUT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FUT5: view

Variants for FUT5 Gene

Sequence variations from dbSNP and Humsavar for FUT5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000155249 -- 5,868,738(+) GCTGA(A/G)GCAGG intron-variant
rs1000561991 -- 5,870,841(+) AGAGC(C/T)GGCAT upstream-variant-2KB
rs1000579951 -- 5,870,558(+) GAGGC(C/T)GAGGC upstream-variant-2KB
rs1000678743 -- 5,872,006(+) ATGTG(A/C)ATTAC upstream-variant-2KB
rs1000746825 -- 5,869,657(+) ATGGT(A/G)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUT5 Gene

Variant ID Type Subtype PubMed ID
nsv1062851 CNV gain 25217958
nsv482210 CNV gain 20164927

Variation tolerance for FUT5 Gene

Residual Variation Intolerance Score: 85.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.97; 94.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT5 Gene

Disorders for FUT5 Gene

Relevant External Links for FUT5

Human Genome Epidemiology (HuGE) Navigator
FUT5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT5

No disorders were found for FUT5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUT5 Gene

Publications for FUT5 Gene

  1. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron H.S. … Weston B.W. (J. Biol. Chem. 1995) 3 4 22 64
  2. Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. (PMID: 1740457) Weston B.W. … Lowe J.B. (J. Biol. Chem. 1992) 2 3 4 64
  3. Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. (PMID: 17148576) Chiu P.C. … Yeung W.S. (J. Cell. Sci. 2007) 3 22 64
  4. Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. (PMID: 10622713) Nishihara S. … Narimatsu H. (FEBS Lett. 1999) 3 22 64
  5. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley R.S. … Weston B.W. (Genomics 1995) 3 22 64

Products for FUT5 Gene

Sources for FUT5 Gene

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