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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT5 Gene

protein-coding   GIFtS: 56
GCID: GC19M005865

fucosyltransferase 5 (alpha (1,3) fucosyltransferase)

 Explore 10 diseases affiliated with
FUT5 via our new
 Human Malady Compendium 
Biological research products
for FUT5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fucosyltransferase 5 (Alpha (1,3) Fucosyltransferase)1 2     Alpha-(1,3)-Fucosyltransferase1
FUC-TV1 2     FucT-V3
Fucosyltransferase V2 3     Fuc-TV3
Galactoside 3-L-Fucosyltransferase2 3     FucT-V3
EC 2.4.1.653 8     Fucosyltransferase 53
Alpha (1,3) Fucosyltransferase2     EC 2.4.18

External Ids:    HGNC: 40161   Entrez Gene: 25272   Ensembl: ENSG000001303837   OMIM: 1368355   UniProtKB: Q111283   

Export aliases for FUT5 gene to outside databases

Previous GC identifers: GC19M005957 GC19M005805 GC19M005816 GC19M005625


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FUT5_HUMAN, Q11128
Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl
Lewis X antigens

Gene Wiki entry for FUT5


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT5 gene promoter:
         c-Fos   E2F   AP-1   NRSF form 1   ATF-2   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUT5 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FUT5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005865:  view genomic region     (about GC identifiers)

Start:
5,865,837 bp from pter      End:
5,903,798 bp from pter
Size:
37,962 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FUT5_HUMAN, Q11128 (See protein sequence)
Recommended Name: Alpha-(1,3)-fucosyltransferase  
Size: 374 amino acids; 43008 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound
form in trans cisternae of Golgi
Secondary accessions: A8K4X2

Explore the universe of human proteins at neXtProt for FUT5: NX_Q11128

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q11128

  • 4/20 DME Specific Peptides for FUT5 (Q11128) (see all 20)
     VPVVLGP  CFFSYLR  FIHVDDF  ADCNITA 

    FUT5 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002025.2  
    ENSEMBL proteins: 
     ENSP00000466880   ENSP00000252675  

    Human Recombinant Protein Products: 
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    Uscn Proteins for FUT5

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS11698403
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--


    FUT5 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FUT5 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001503 Glyco_trans_10

    Graphical View of Domain Structure for InterPro Entry Q11128

    ProtoNet protein and cluster: Q11128

    1 Blocks protein family: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT5_HUMAN, Q11128
    Similarity: Belongs to the glycosyltransferase 10 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FUT5_HUMAN, Q11128
    Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl
    Lewis X antigens
    Catalytic activity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +
    beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R

         Genatlas biochemistry entry for FUT5:
    fucosyltransferase,alpha-(1,3),5 (FucT-V),plasma

    Enzyme Numbers (IUBMB): EC 2.4.1.651 2 EC 2.4.12

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008417fucosyltransferase activity TAS1339443
    GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA--
    GO:0046920alpha-(1->3)-fucosyltransferase activity TAS11698403


    FUT5 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FUT5:
     Increased circadian period len 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series1.00
    2Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for FUT5):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT5_HUMAN, Q11128
    Pathway: Protein modification; protein glycosylation


    FUT5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FUT5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    5/16 Interacting proteins for FUT5 (ENSP000002526754) via UniProtKB, MINT, STRING, and/or I2D (see all 16)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GNT3ENSP000003218744STRING: ENSP00000321874
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    FUT1ENSP000003120214STRING: ENSP00000312021
    FUT2ENSP000003757484STRING: ENSP00000375748
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS1339443
    GO:0006486protein glycosylation TAS11698403
    GO:0036065fucosylation TAS1339443
    GO:0042355L-fucose catabolic process NAS11698403


    FUT5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT5

    2 HMDB Compounds for FUT5    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    2 Novoseek chemical compound relationships for FUT5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp fucose 81.5 1 7721776 (1)
    gdp 46.7 1 8780523 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT5 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FUT5 gene: 
    NM_002034.2  

    Unigene Cluster for FUT5:

    Fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
    Hs.631843  [show with all ESTs]
    Unigene Representative Sequence: NM_002034
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000588525 ENST00000252675(uc002mdo.4 uc010duo.3)

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    Additional cDNA sequence: 

    BC140905.1 U27329.1 U27330.1 

    1 DOTS entry:

    DT.105397 

    3 AceView cDNA sequences:

    NM_002034 U27329 U27330 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGGGGTGCAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FUT5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT5

    SOURCE GeneReport for Unigene cluster: Hs.631843

    UniProtKB/Swiss-Prot: FUT5_HUMAN, Q11128
    Tissue specificity: Liver, colon and testis and trace amounts in T-cells and brain

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    In Situ
    Assay Products:
     

     
    Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for FUT5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUT5 gene from 5/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FUT51 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 60.19(n)
    51.59(a)
      428341  XM_425901.1  XP_425901.1 
    lizard
    (Anolis carolinensis)
    Reptilia FUT106
    --
    13(a)
    possible ortholog
    GL343339.1(1146655-1163889)
    zebrafish
    (Danio rerio)
    Actinopterygii CT485993.16
    CABZ01086789.16
    --
    37(a)
    34(a)
    possible ortholog
    possible ortholog
    17(15480578-15481706)
    5(26911359-26912408)
    fruit fly
    (Drosophila melanogaster)
    Insecta FucTA1 , 3 protein amino acid glycosylation galactoside
    3-L-fucosyltransferase3
    CG6869-PA1
    35(a)
    (best of 2)3
    53.75(n)1
    39.53(a)1
      71B63
    396531  NM_140497.21  NP_648754.21 
    worm
    (Caenorhabditis elegans)
    Secernentea fut-31 Protein FUT-3 41.9(n)
    32.99(a)
      173958  NM_062705.6  NP_495106.1 
            Species with no ortholog for FUT5

    ENSEMBL Gene Tree for FUT5 (if available)
    TreeFam Gene Tree for FUT5 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT5 gene
    FUT42  FUT72  FUT62  FUT32  FUT102  FUT112  FUT92  
    5 SIMAP similar genes for FUT5 using alignment to 2 protein entries:     FUT5_HUMAN (see all proteins):
    FUT3    FUT6    FUT9    FUT7    FUT4

    FUT5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/224 NCBI SNPs in FUT5 are shown (see all 224    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1143308421,2
    F,--5865445(+) GACCTG/AAGACC 1 -- ds50011Minor allele frequency- A:0.03WA 118
    rs779338181,2
    C,--5865470(+) TTTCAC/ATTCTG 1 -- ds50012Minor allele frequency- A:0.07WA 120
    rs1499365451,2
    --5865540(+) GAACGA/CCTCCC 1 -- ds50010--------
    rs1926154791,2
    --5865604(+) CCCTGA/GACATT 1 -- ds50010--------
    rs1449891011,2
    --5865624(+) CATTGC/TTGGTT 1 -- ds50010--------
    rs104267091,2
    C,F,H,--5865645(+) CGACTC/TGTGCA 1 -- ds500121Minor allele frequency- T:0.08NS EA NA CSA WA 2642
    rs735386521,2
    C,--5865672(+) GTAACC/ACTGGC 1 -- ds50012Minor allele frequency- A:0.13WA 120
    rs1844886271,2
    --5865804(+) AGGGGA/GGACAC 1 -- ds50010--------
    rs118814701,2
    C,F,H,--5865837(+) TCGCCT/CGAAAA 1 -- ut3120Minor allele frequency- C:0.04NS EA NA WA 2036
    rs1490685441,2
    C,--5865907(+) CAAGCA/CAACCA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FUT5 (5865837 - 5903798 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FUT5: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FUT5 for disorders           About GeneDecksing

    OMIM gene information: 136835    OMIM disorders: --

    10 diseases for FUT5:    About MalaCards
    cytomegalovirus infection    herpes simplex    colon carcinoma    gastric cancer
    lung carcinoma    colorectal cancer    prostate cancer    breast cancer
    carcinoma    prostatitis

    Human Genome Epidemiology (HuGE) Navigator: FUT5 (1 document)

    Export disorders for FUT5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT5 gene, integrated from 9 sources (see all 45):
    (articles sorted by number of sources associating them with FUT5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. (PubMed id 1740457)1, 2, 3 Weston B.W....Lowe J.B. (1992)
    2. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PubMed id 7650030)1, 2, 9 Cameron H.S.... Weston B.W. (1995)
    3. Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. (PubMed id 17148576)1, 9 Chiu P.C....Yeung W.S. (2007)
    4. Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. (PubMed id 10622713)1, 9 Nishihara S....Narimatsu H. (1999)
    5. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PubMed id 7782074)1, 9 McCurley R.S....Weston B.W. (1995)
    6. [Distribution specificity of human fucosyltransferase 5 and its expression and localization in spermatids]. (PubMed id 22619806)1 Li F.R....Pang H. (2012)
    7. Down-regulation of FUT3 and FUT5 by shRNA alters Lewi s antigens expression and reduces the adhesion capacities of gastric cancer cel ls. (PubMed id 21978830)1 PadrA^ M....de BolA^s C. (2011)
    8. [The genetic diversity in the full coding region of h uman FUT5 gene in a Chinese Han population]. (PubMed id 20677162)1 Li F.R....Pang H. (2010)
    9. Activation of host antiviral RNA-sensing factors nece ssary for herpes simplex virus type 1-activated transcription of host cell fuco syltransferase genes FUT3, FUT5, and FUT6 and subsequent expression of sLe(x) i n virus-infected cells. (PubMed id 19349624)1 NordAcn R....Olofsson S. (2009)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2527 HGNC: 4016 AceView: FUT5 Ensembl:ENSG00000130383 euGenes: HUgn2527
    ECgene: FUT5 Kegg: 2527 H-InvDB: FUT5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT5 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT5
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_602

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FUT5 gene:
    Search GeneIP for patents involving FUT5

    GeneCards and IP:
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