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Aliases for FUT5 Gene

Aliases for FUT5 Gene

  • Fucosyltransferase 5 (Alpha (1,3) Fucosyltransferase) 2 3
  • Galactoside 3-L-Fucosyltransferase 3 4
  • Fucosyltransferase V 3 4
  • EC 2.4.1.65 4 64
  • FUC-TV 3 4
  • FucT-V 3 4
  • Alpha-(1,3)-Fucosyltransferase 5 3
  • Alpha (1,3) Fucosyltransferase 3
  • Fucosyltransferase 5 4
  • EC 2.4.1 64

External Ids for FUT5 Gene

Summaries for FUT5 Gene

GeneCards Summary for FUT5 Gene

FUT5 (Fucosyltransferase 5 (Alpha (1,3) Fucosyltransferase)) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT5 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens

Gene Wiki entry for FUT5 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT5 Gene

Genomics for FUT5 Gene

Genomic Location for FUT5 Gene

Start:
5,865,826 bp from pter
End:
5,870,540 bp from pter
Size:
4,715 bases
Orientation:
Minus strand

Genomic View for FUT5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT5 Gene

Regulatory Elements for FUT5 Gene

Proteins for FUT5 Gene

  • Protein details for FUT5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q11128-FUT5_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 5
    Protein Accession:
    Q11128
    Secondary Accessions:
    • A8K4X2

    Protein attributes for FUT5 Gene

    Size:
    374 amino acids
    Molecular mass:
    43008 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT5 Gene

Proteomics data for FUT5 Gene at MOPED

Post-translational modifications for FUT5 Gene

  • Glycosylation at Asn60, Asn105, Asn167, and Asn198

Other Protein References for FUT5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FUT5 Gene

Gene Families for FUT5 Gene

HGNC:
  • FUT :Fucosyltransferases

Protein Domains for FUT5 Gene

UniProtKB/Swiss-Prot:

FUT5_HUMAN
Family:
  • Belongs to the glycosyltransferase 10 family.:
    • Q11128
genes like me logo Genes that share domains with FUT5: view

Function for FUT5 Gene

Molecular function for FUT5 Gene

GENATLAS Biochemistry: fucosyltransferase,alpha-(1,3),5 (FucT-V),plasma
UniProtKB/Swiss-Prot CatalyticActivity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R
UniProtKB/Swiss-Prot Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens

Enzyme Numbers (IUBMB) for FUT5 Gene

Gene Ontology (GO) - Molecular Function for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 1339443
GO:0017060 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT5: view

Phenotypes for FUT5 Gene

GenomeRNAi human phenotypes for FUT5:
genes like me logo Genes that share phenotypes with FUT5: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FUT5 Gene

Localization for FUT5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT5 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT5 Gene COMPARTMENTS Subcellular localization image for FUT5 gene
Compartment Confidence
golgi apparatus 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT5: view

Pathways for FUT5 Gene

genes like me logo Genes that share pathways with FUT5: view

Pathways by source for FUT5 Gene

UniProtKB/Swiss-Prot Q11128-FUT5_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for FUT5 Gene

Gene Ontology (GO) - Biological Process for FUT5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 1339443
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation TAS 11698403
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT5: view

Compounds for FUT5 Gene

(2) HMDB Compounds for FUT5 Gene

Compound Synonyms Cas Number PubMed IDs
GDP-L-fucose
  • GDP-beta-L-fucose
15839-70-0
Guanosine diphosphate
  • 5'-GDP
146-91-8

(2) Novoseek inferred chemical compound relationships for FUT5 Gene

Compound -log(P) Hits PubMed IDs
gdp fucose 81.5 1
gdp 46.7 1
genes like me logo Genes that share compounds with FUT5: view

Transcripts for FUT5 Gene

mRNA/cDNA for FUT5 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT5 Gene

Fucosyltransferase 5 (alpha (1,3) fucosyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT5 Gene

No ASD Table

Relevant External Links for FUT5 Gene

GeneLoc Exon Structure for
FUT5
ECgene alternative splicing isoforms for
FUT5

Expression for FUT5 Gene

mRNA expression in normal human tissues for FUT5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUT5 Gene

SOURCE GeneReport for Unigene cluster for FUT5 Gene Hs.631843

mRNA Expression by UniProt/SwissProt for FUT5 Gene

Q11128-FUT5_HUMAN
Tissue specificity: Liver, colon and testis and trace amounts in T-cells and brain
genes like me logo Genes that share expressions with FUT5: view

Orthologs for FUT5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT5 36
  • 98.31 (n)
  • 97.86 (a)
FUT5 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 68 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FUT5 37
  • 67 (a)
ManyToMany
FUT5 37
  • 67 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 46 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 55 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
-- 37
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000365 36
  • 52.95 (n)
  • 40 (a)
fruit fly
(Drosophila melanogaster)
Insecta FucTC 36
  • 26 (n)
  • 8.11 (a)
FucTA 38
  • 35 (a)
FucTC 38
  • 32 (a)
Species with no ortholog for FUT5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT5 Gene

ENSEMBL:
Gene Tree for FUT5 (if available)
TreeFam:
Gene Tree for FUT5 (if available)

Paralogs for FUT5 Gene

Paralogs for FUT5 Gene

Selected SIMAP similar genes for FUT5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FUT5: view

Variants for FUT5 Gene

Sequence variations from dbSNP and Humsavar for FUT5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs374028 -- 5,866,538(+) GTGAG(A/G)CCCTA utr-variant-3-prime
rs407788 -- 5,866,571(+) TGAGG(C/T)CCCGG utr-variant-3-prime
rs702065 -- 5,866,829(+) TCGGG(C/T)GGCAG reference, synonymous-codon
rs778970 - 5,867,166(+) ACCAC(A/G)GCTCC reference, missense
rs778971 -- 5,867,737(-) CCCAG(A/C)TACTC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for FUT5 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
nsv910904 CNV Loss 21882294
nsv482210 CNV Gain 20164927
nsv910905 CNV Loss 21882294

Relevant External Links for FUT5 Gene

HapMap Linkage Disequilibrium report
FUT5

Disorders for FUT5 Gene

Relevant External Links for FUT5

Human Genome Epidemiology (HuGE) Navigator
FUT5
genes like me logo Genes that share disorders with FUT5: view

No data available for UniProtKB/Swiss-Prot for FUT5 Gene

Publications for FUT5 Gene

  1. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PMID: 7650030) Cameron H.S. … Weston B.W. (J. Biol. Chem. 1995) 3 4 23
  2. Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities. (PMID: 1740457) Weston B.W. … Lowe J.B. (J. Biol. Chem. 1992) 2 3 4
  3. Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue. (PMID: 10622713) Nishihara S. … Narimatsu H. (FEBS Lett. 1999) 3 23
  4. Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21. (PMID: 7782074) McCurley R.S. … Weston B.W. (Genomics 1995) 3 23
  5. Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding. (PMID: 17148576) Chiu P.C. … Yeung W.S. (J. Cell. Sci. 2007) 3 23

Products for FUT5 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate FUT5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for FUT5
    • Block miRNA regulation of FUT5 using miScript Target Protectors

    Sources for FUT5 Gene

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