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Aliases for FUT4 Gene

Aliases for FUT4 Gene

  • Fucosyltransferase 4 (Alpha (1,3) Fucosyltransferase, Myeloid-Specific) 2 3
  • Galactoside 3-L-Fucosyltransferase 2 3 4
  • FCT3A 3 4 6
  • ELAM-1 Ligand Fucosyltransferase 3 4
  • ELAM Ligand Fucosyltransferase 2 3
  • Fucosyltransferase IV 3 4
  • FUC-TIV 3 4
  • FucT-IV 3 4
  • ELFT 3 4
  • CD15 3 6
  • Stage-Specific Embryonic Antigen 1 3
  • Alpha-(1,3)-Fucosyltransferase 4 3
  • Fucosyltransferase 4 4
  • EC 63
  • EC 2.4.1.- 4
  • EC 2.4.1 63
  • Lewis X 3
  • SSEA-1 3
  • FUTIV 3
  • LeX 3

External Ids for FUT4 Gene

Previous HGNC Symbols for FUT4 Gene

  • CD15
  • FCT3A
  • ELFT

Previous GeneCards Identifiers for FUT4 Gene

  • GC11P096607
  • GC11P095784
  • GC11P094461
  • GC11P093965
  • GC11P093916
  • GC11P094277
  • GC11P090342

Summaries for FUT4 Gene

Entrez Gene Summary for FUT4 Gene

  • The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]

GeneCards Summary for FUT4 Gene

FUT4 (Fucosyltransferase 4 (Alpha (1,3) Fucosyltransferase, Myeloid-Specific)) is a Protein Coding gene. Diseases associated with FUT4 include myeloid sarcoma and benign mesothelioma. Among its related pathways are Metabolism and Other types of O-glycan biosynthesis. GO annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT4 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT4 Gene

Genomics for FUT4 Gene

Regulatory Elements for FUT4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FUT4 Gene

94,543,840 bp from pter
94,549,898 bp from pter
6,059 bases
Plus strand

Genomic View for FUT4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT4 Gene

Proteins for FUT4 Gene

  • Protein details for FUT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 4
    Protein Accession:
    Secondary Accessions:
    • B2RMS0

    Protein attributes for FUT4 Gene

    530 amino acids
    Molecular mass:
    59084 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAB20349.1; Type=Frameshift; Positions=114; Evidence={ECO:0000305};

neXtProt entry for FUT4 Gene

Proteomics data for FUT4 Gene at MOPED

Selected DME Specific Peptides for FUT4 Gene

Post-translational modifications for FUT4 Gene

  • Glycosylation at Asn216 and Asn315
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for FUT4 (FUT4)

Domains for FUT4 Gene

Gene Families for FUT4 Gene

  • CD :CD molecules
  • FUT :Fucosyltransferases

Protein Domains for FUT4 Gene

Suggested Antigen Peptide Sequences for FUT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P22083
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT4: view

Function for FUT4 Gene

Molecular function for FUT4 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),4,(FucT-IV),myeloid;same as CD15
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens

Enzyme Numbers (IUBMB) for FUT4 Gene

Gene Ontology (GO) - Molecular Function for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 1716630
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT4: view
genes like me logo Genes that share phenotypes with FUT4: view

Animal Models for FUT4 Gene

MGI Knock Outs for FUT4:

miRNA for FUT4 Gene

miRTarBase miRNAs that target FUT4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT4

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for FUT4 Gene

Localization for FUT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

Jensen Localization Image for FUT4 Gene COMPARTMENTS Subcellular localization image for FUT4 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 2
extracellular 2
nucleus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 1716630
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT4: view

Pathways for FUT4 Gene

genes like me logo Genes that share pathways with FUT4: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot P22083-FUT4_HUMAN

  • Pathway: Protein modification; protein glycosylation

Gene Ontology (GO) - Biological Process for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 1716630
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation TAS 11698403
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT4: view

Compounds for FUT4 Gene

(14) Novoseek inferred chemical compound relationships for FUT4 Gene

Compound -log(P) Hits PubMed IDs
gdp fucose 85.1 1
n-acetyllactosamine 79.8 5
polylactosamine 67 3
tetrasaccharide 64.8 2
l-fucose 52.4 1
genes like me logo Genes that share compounds with FUT4: view

Transcripts for FUT4 Gene

mRNA/cDNA for FUT4 Gene

(16) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT4 Gene

Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUT4

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT4 Gene

No ASD Table

Relevant External Links for FUT4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUT4 Gene

mRNA expression in normal human tissues for FUT4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FUT4 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUT4 Gene

SOURCE GeneReport for Unigene cluster for FUT4 Gene Hs.390420

genes like me logo Genes that share expressions with FUT4: view

Expression partners for FUT4 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FUT4 Gene

Orthologs for FUT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FUT4 35
  • 82.74 (n)
  • 77.13 (a)
FUT4 36
  • 75 (a)
(Canis familiaris)
Mammalia LOC100682680 35
  • 85.53 (n)
  • 86.23 (a)
FUT4 36
  • 89 (a)
(Mus musculus)
Mammalia Fut4 35
  • 77.25 (n)
  • 74.82 (a)
Fut4 16
Fut4 36
  • 74 (a)
(Pan troglodytes)
Mammalia FUT4 35
  • 99.5 (n)
  • 99.06 (a)
FUT4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Fut4 35
  • 78.12 (n)
  • 78.59 (a)
(Monodelphis domestica)
Mammalia FUT4 36
  • 64 (a)
(Gallus gallus)
Aves FUT4 35
  • 69.6 (n)
  • 62.31 (a)
FUT4 36
  • 62 (a)
(Anolis carolinensis)
Reptilia FUT4 36
  • 55 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fut4 35
  • 58.31 (n)
  • 54.43 (a)
Species with no ortholog for FUT4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT4 Gene

Gene Tree for FUT4 (if available)
Gene Tree for FUT4 (if available)

Paralogs for FUT4 Gene

Paralogs for FUT4 Gene

Selected SIMAP similar genes for FUT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUT4: view

Variants for FUT4 Gene

Sequence variations from dbSNP and Humsavar for FUT4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs542968 -- 94,548,328(-) gaggc(A/G)gaggt utr-variant-3-prime
rs659284 -- 94,548,148(+) ATAAA(A/T)TGGTA utr-variant-3-prime
rs687688 -- 94,543,426(-) TCACT(A/G)TTAAT upstream-variant-2KB
rs2230273 - 94,544,896(+) GGGGC(A/G)TCCAG reference, missense
rs2230274 -- 94,545,547(+) CGTAC(C/T)TGCTT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for FUT4 Gene

Variant ID Type Subtype PubMed ID
esv2671948 CNV Deletion 23128226

Relevant External Links for FUT4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT4 Gene

Disorders for FUT4 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for FUT4 Gene in MalaCards »

(4) Diseases for FUT4 Gene including...

(9) Novoseek inferred disease relationships for FUT4 Gene

Disease -log(P) Hits PubMed IDs
colon adenocarcinoma 47.9 5
colon cancer 36.9 1
colon carcinoma 24.6 1
gastric cancer 4.58 1
leukemia 0 2
genes like me logo Genes that share disorders with FUT4: view

No data available for OMIM , UniProtKB/Swiss-Prot , Genatlas and External Links for FUT4 Gene

Publications for FUT4 Gene

  1. ELFT: a gene that directs the expression of an ELAM-1 ligand. (PMID: 1702034) Goelz S.E. … Lobb R. (Cell 1990) 2 3 4 23
  2. Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. (PMID: 1716630) Lowe J.B. … Ernst L.K. (J. Biol. Chem. 1991) 3 4
  3. Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants. (PMID: 1718983) Kumar R. … Stanley P. (J. Biol. Chem. 1991) 3 4
  4. Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line. (PMID: 11006292) Withers D.A. … Hakomori S.I. (J. Biol. Chem. 2000) 3 23
  5. Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis. (PMID: 15182935) Azuma Y. … Matsumoto K. (Biochim. Biophys. Acta 2004) 3 23

Products for FUT4 Gene

Sources for FUT4 Gene

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