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Aliases for FUT4 Gene

Aliases for FUT4 Gene

  • Fucosyltransferase 4 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 2 3 4
  • Alpha (1,3) Fucosyltransferase, Myeloid-Specific 2 3
  • ELAM-1 Ligand Fucosyltransferase 3 4
  • ELAM Ligand Fucosyltransferase 2 3
  • Fucosyltransferase IV 3 4
  • FUC-TIV 3 4
  • FucT-IV 3 4
  • FCT3A 3 4
  • ELFT 3 4
  • Fucosyltransferase 4 (Alpha (1,3) Fucosyltransferase, Myeloid-Specific) 3
  • Stage-Specific Embryonic Antigen 1 3
  • Alpha-(1,3)-Fucosyltransferase 4 3
  • EC 2.4.1.65 61
  • EC 2.4.1.- 4
  • EC 2.4.1 61
  • Lewis X 3
  • SSEA-1 3
  • FUTIV 3
  • CD15 3
  • LeX 3

External Ids for FUT4 Gene

Previous HGNC Symbols for FUT4 Gene

  • CD15
  • FCT3A
  • ELFT

Previous GeneCards Identifiers for FUT4 Gene

  • GC11P096607
  • GC11P095784
  • GC11P094461
  • GC11P093965
  • GC11P093916
  • GC11P094277
  • GC11P090342

Summaries for FUT4 Gene

Entrez Gene Summary for FUT4 Gene

  • The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). [provided by RefSeq, Jan 2009]

GeneCards Summary for FUT4 Gene

FUT4 (Fucosyltransferase 4) is a Protein Coding gene. Diseases associated with FUT4 include Liver Lymphoma and Sternum Cancer. Among its related pathways are Other types of O-glycan biosynthesis and Metabolism. GO annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT4 Gene

  • May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT4 Gene

Genomics for FUT4 Gene

Regulatory Elements for FUT4 Gene

Enhancers for FUT4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FUT4 on UCSC Golden Path with GeneCards custom track

Promoters for FUT4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUT4 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUT4 Gene

Chromosome:
11
Start:
94,543,840 bp from pter
End:
94,549,898 bp from pter
Size:
6,059 bases
Orientation:
Plus strand

Genomic View for FUT4 Gene

Genes around FUT4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT4 Gene

Proteins for FUT4 Gene

  • Protein details for FUT4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22083-FUT4_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 4
    Protein Accession:
    P22083
    Secondary Accessions:
    • B2RMS0

    Protein attributes for FUT4 Gene

    Size:
    530 amino acids
    Molecular mass:
    59084 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB20349.1; Type=Frameshift; Positions=114; Evidence={ECO:0000305};

neXtProt entry for FUT4 Gene

Selected DME Specific Peptides for FUT4 Gene

Post-translational modifications for FUT4 Gene

  • Glycosylation at Asn 216 and Asn 315
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT4 Gene

Gene Families for FUT4 Gene

Protein Domains for FUT4 Gene

Suggested Antigen Peptide Sequences for FUT4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P22083

UniProtKB/Swiss-Prot:

FUT4_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT4: view

Function for FUT4 Gene

Molecular function for FUT4 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3),4,(FucT-IV),myeloid;same as CD15
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens.

Enzyme Numbers (IUBMB) for FUT4 Gene

Gene Ontology (GO) - Molecular Function for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008417 fucosyltransferase activity TAS 1716630
GO:0046920 alpha-(1->3)-fucosyltransferase activity TAS 11698403
genes like me logo Genes that share ontologies with FUT4: view
genes like me logo Genes that share phenotypes with FUT4: view

Animal Models for FUT4 Gene

MGI Knock Outs for FUT4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT4 Gene

Localization for FUT4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT4 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT4 Gene COMPARTMENTS Subcellular localization image for FUT4 gene
Compartment Confidence
golgi apparatus 5
cytoskeleton 2
cytosol 2
extracellular 2
lysosome 2
nucleus 2
plasma membrane 2
vacuole 2
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus TAS 11698403
GO:0009986 cell surface IEA --
GO:0016020 membrane TAS 1716630
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT4: view

Pathways & Interactions for FUT4 Gene

genes like me logo Genes that share pathways with FUT4: view

Pathways by source for FUT4 Gene

UniProtKB/Swiss-Prot P22083-FUT4_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 1716630
GO:0006486 protein glycosylation TAS 11698403
GO:0006487 protein N-linked glycosylation IBA --
GO:0036065 fucosylation IEA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT4: view

No data available for SIGNOR curated interactions for FUT4 Gene

Drugs & Compounds for FUT4 Gene

(1) Drugs for FUT4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(13) Additional Compounds for FUT4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FUT4: view

Transcripts for FUT4 Gene

mRNA/cDNA for FUT4 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT4 Gene

Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUT4 Gene

No ASD Table

Relevant External Links for FUT4 Gene

GeneLoc Exon Structure for
FUT4
ECgene alternative splicing isoforms for
FUT4

Expression for FUT4 Gene

mRNA expression in normal human tissues for FUT4 Gene

Protein differential expression in normal tissues from HIPED for FUT4 Gene

This gene is overexpressed in Stomach (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUT4 Gene



Protein tissue co-expression partners for FUT4 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT4 Gene:

FUT4

SOURCE GeneReport for Unigene cluster for FUT4 Gene:

Hs.390420
genes like me logo Genes that share expression patterns with FUT4: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FUT4 Gene

Orthologs for FUT4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT4 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FUT4 34
  • 82.74 (n)
  • 77.13 (a)
FUT4 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC100682680 34
  • 85.53 (n)
  • 86.23 (a)
FUT4 35
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fut4 34
  • 77.25 (n)
  • 74.82 (a)
Fut4 16
Fut4 35
  • 74 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FUT4 34
  • 99.5 (n)
  • 99.06 (a)
FUT4 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut4 34
  • 78.12 (n)
  • 78.59 (a)
oppossum
(Monodelphis domestica)
Mammalia FUT4 35
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUT4 34
  • 69.6 (n)
  • 62.31 (a)
FUT4 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUT4 35
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fut4 34
  • 58.31 (n)
  • 54.43 (a)
Species where no ortholog for FUT4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT4 Gene

ENSEMBL:
Gene Tree for FUT4 (if available)
TreeFam:
Gene Tree for FUT4 (if available)

Paralogs for FUT4 Gene

Paralogs for FUT4 Gene

(5) SIMAP similar genes for FUT4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUT4: view

Variants for FUT4 Gene

Sequence variations from dbSNP and Humsavar for FUT4 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2230273 - 94,544,896(+) GGGGC(A/G)TCCAG reference, missense
rs7944378 -- 94,543,125(+) TCCTT(A/C)GGTCA upstream-variant-2KB
rs7950626 -- 94,543,495(+) GGGGG(C/T)CACAT upstream-variant-2KB
rs34172807 -- 94,542,808(+) ATTTT(A/T)AGTGG upstream-variant-2KB
rs10673259 -- 94,549,901(+) GACTC(-/TT)TGTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for FUT4 Gene

Variant ID Type Subtype PubMed ID
esv2671948 CNV deletion 23128226
esv3580028 CNV gain 25503493
nsv951059 CNV duplication 24416366

Variation tolerance for FUT4 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT4 Gene

Disorders for FUT4 Gene

MalaCards: The human disease database

(32) MalaCards diseases for FUT4 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
liver lymphoma
  • lymphoma of liver
sternum cancer
  • malignant sternal neoplasm
malignant ovarian cyst
colorectal cancer
  • colorectal cancer, somatic
adult xanthogranuloma
- elite association - COSMIC cancer census association via MalaCards
Search FUT4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT4
genes like me logo Genes that share disorders with FUT4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT4 Gene

Publications for FUT4 Gene

  1. ELFT: a gene that directs the expression of an ELAM-1 ligand. (PMID: 1702034) Goelz S.E. … Lobb R. (Cell 1990) 2 3 4 22 65
  2. Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis. (PMID: 17409497) Azuma Y. … Matsumoto K. (Biol. Pharm. Bull. 2007) 3 22 65
  3. Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis. (PMID: 15182935) Azuma Y. … Matsumoto K. (Biochim. Biophys. Acta 2004) 3 22 65
  4. Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line. (PMID: 11006292) Withers D.A. … Hakomori S.I. (J. Biol. Chem. 2000) 3 22 65
  5. Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. (PMID: 1716630) Lowe J.B. … Ernst L.K. (J. Biol. Chem. 1991) 3 4 65

Products for FUT4 Gene

Sources for FUT4 Gene

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