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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT4 Gene

protein-coding   GIFtS: 55
GCID: GC11P094277

fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)


(Previous symbols: CD15, FCT3A, ELFT)
 Explore 36 diseases affiliated with
FUT4 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FUT4    

Aliases
for FUT4 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fucosyltransferase 4 (Alpha (1,3) Fucosyltransferase, Myeloid-Specific)1 2     Alpha-(1,3)-Fucosyltransferase1
FCT3A1 2 3 5     ELAM Ligand Fucosyltransferase2
ELFT1 2 3     FucT-IV3
CD151 2 5     Lewis X2
FUC-TIV1 2     Stage-Specific Embryonic Antigen 12
Fucosyltransferase IV2 3     EC 2.4.1.-3
Galactoside 3-L-Fucosyltransferase2 3     Fuc-TIV3
ELAM-1 Ligand Fucosyltransferase2 3     FucT-IV3
FUTIV2     Fucosyltransferase 43
LeX2     EC 2.4.18
SSEA-12     EC 2.4.1.658

External Ids:    HGNC: 40151   Entrez Gene: 25262   Ensembl: ENSG000001963717   OMIM: 1042305   UniProtKB: P220833   

Export aliases for FUT4 gene to outside databases

Previous GC identifers: GC11P096607 GC11P095784 GC11P094461 GC11P093965 GC11P093916 GC11P090342


Summaries
for FUT4 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FUT4:
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate
structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). (provided by RefSeq, Jan 2009)

UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083
Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens




Genomic Views
for FUT4 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT4 gene promoter:
         Pax-5   AP-1   ATF-2   CUTL1   Cdc5   C/EBPalpha   CP2   c-Jun   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FUT4 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

FUT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P094277:  view genomic region     (about GC identifiers)

Start:
 94,277,017 bp from pter      End:
 94,283,064 bp from pter
Size:
 6,048 bases      Orientation:
 plus strand

Proteins
for FUT4 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083 (See protein sequence)
Recommended Name: Alpha-(1,3)-fucosyltransferase  
Size: 530 amino acids; 59084 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound
form in trans cisternae of Golgi
Caution: It is uncertain whether Met-1 or Met-126 is the initiator
Sequence caution: Sequence=AAB20349.1; Type=Frameshift; Positions=114;
Secondary accessions: B2RMS0

Explore the universe of human proteins at neXtProt for FUT4: NX_P22083

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P22083

    • 4/10 DME Specific Peptides for FUT4 (P22083) (see all 10)
     VPVVLGP  DWPPPWG  FIHVDDF  RFNISGC 

    FUT4 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_002024.1  
    ENSEMBL proteins: 
     ENSP00000351602  

    Human Recombinant Protein Products: 
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    Uscn Proteins for FUT4

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005624membrane fraction ----
    GO:0005794Golgi apparatus TAS11698403
    GO:0009986cell surface IEA--
    GO:0016020membrane TAS1716630
    GO:0016021integral to membrane IEA--


    FUT4 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for FUT4

    Protein Domains /
    Families
    for FUT4 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FUT4 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001503 Glyco_trans_10

    Graphical View of Domain Structure for InterPro Entry P22083

    ProtoNet protein and cluster: P22083

    1 Blocks protein family: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083
    Similarity: Belongs to the glycosyltransferase 10 family


    Function
    for FUT4 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083
    Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2 antigens

         Genatlas biochemistry entry for FUT4:
    fucosyltransferase,alpha-(1,3),4,(FucT-IV),myeloid;same as CD15

    Enzyme Numbers (IUBMB): EC 2.4.1.652 EC 2.4.12 EC 2.4.1.-1

    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate FUT4 (see all 40):
    hsa-miR-345 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-23a hsa-miR-642b hsa-miR-3622a-5p hsa-miR-4324
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for FUT4

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT4

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008417fucosyltransferase activity TAS1716630
    GO:0046920alpha-(1->3)-fucosyltransferase activity TAS11698403


    FUT4 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Fut4tm1Jbl for FUT4
         4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fut4):
     cardiovascular system  cellular  hematopoietic system  immune system 

    FUT4 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FUT4 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycosphingolipid biosynthesis - lacto and neolacto series
    		Glycosphingolipid biosynthesis - lacto and neolacto series1.00
    2Metabolism
    		Metabolic pathways0.38
    3Glucuronidation
    		Other types of O-glycan biosynthesis0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    3         Kegg Pathways  (Kegg details for FUT4):
        Other types of O-glycan biosynthesis
    Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083
    Pathway: Protein modification; protein glycosylation


    FUT4 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/22 Interacting proteins for FUT4 (P220833 ENSP000003516024) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    CR1P179273, ENSP000003560164I2D: score=2 STRING: ENSP00000356016
    ISG15P051613, ENSP000003686994I2D: score=1 STRING: ENSP00000368699
    SELPP161093, ENSP000002636864I2D: score=2 STRING: ENSP00000263686
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS1716630
    GO:0006486protein glycosylation TAS11698403
    GO:0036065fucosylation TAS1716630
    GO:0042355L-fucose catabolic process NAS11698403


    FUT4 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FUT4 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT4 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT4
    10/14 Novoseek chemical compound relationships for FUT4 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp fucose 85.1 1 8925514 (1)
    n-acetyllactosamine 79.8 6 7591266 (1), 1490103 (1), 7528213 (1), 9461592 (1) (see all 5)
    polylactosamine 67 3 9461592 (2), 10622713 (1)
    tetrasaccharide 64.8 2 16199102 (1), 10211980 (1)
    l-fucose 52.4 1 8925514 (1)
    polysaccharide 48.1 2 16980970 (1), 9461592 (1)
    n-acetylglucosamine 47 2 1490103 (1), 8400824 (1)
    galactose 39.8 1 9648267 (1)
    glycolipid 37.4 2 10362832 (1), 7721776 (1)
    sialic acid 32.8 1 9461592 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT4 

    Transcripts
    for FUT4 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FUT4 gene: 
    NM_002033.3  

    Unigene Clusters for FUT4:

    Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
    Hs.390420  [show with all ESTs], Hs.572064  [show with all ESTs]
    Unigene Representative Sequences: NM_002033, BC041922
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000358752(uc001pez.3)

    miRNA
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    8/40 QIAGEN miScript miRNA Assays for microRNAs that regulate FUT4 (see all 40):
    hsa-miR-345 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-23a hsa-miR-642b hsa-miR-3622a-5p hsa-miR-4324
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUT4 (see all 7)
    OriGene shRNA RFP: FUT4
    OriGene siRNA: FUT4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUT4
    Clone
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    GenScript: all cDNA clones in your preferred vector: FUT4 (NM_002033)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUT4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUT4

    Additional cDNA sequence: BC041922.1 

    3 DOTS entries:

    DT.312151  DT.120701170  DT.308754 

    16 AceView cDNA sequences:

    BM930393 BM718196 BQ187068 BQ189767 AI475919 AI796025 BI522896 BG897709 
    BI522712 BC041922 BI597047 BE858128 BF941734 BM930245 AW028257 BF057407 

    GeneLoc Exon Structure


    Expression
    for FUT4 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCAGATTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FUT4 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AmnionAmniotic MembraneAmniotic CellsAmnion, Extraembryonic Tissues
    BoneBone MarrowMyeloid CellsBlood
    PlacentaAllantoisPrimordial Germ CellsGerm Cells
    LimbLimb BudLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/21 LifeMap Cells (see all 21) 
    NameCategory
    Induced pluripotent stem cells (Sickle Cell Anemia patient) (Induced Pluripotent Stem Cell)Early Embryo, Fibroblast
    Otx2-GFP genetically modified stem cells (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Neural stem cells (Fetal Stem / Progenitor Cell)Spinal Cord
    Human multipotent adipose-derived (hMAD) stem cells (Adult Stem / Progenitor Cell)Adipose
    HSF-1 (UC01) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    SHEF-4 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB02 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB03_DM1 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    VUB04_CF (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    SHEF-1 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass

    See FUT4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT4

    SOURCE GeneReport for Unigene clusters: Hs.390420 Hs.572064
        SABiosciences Expression via Pathway-Focused PCR Array including FUT4: 
              Mesenchymal Stem Cell in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for FUT4 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FUT4 gene from 5/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves FUT41 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, more 70.3(n)
    62.75(a)    		   428092  NM_001031487.1  NP_001026658.1 
    lizard
    (Anolis carolinensis)    		 Reptilia FUT46
    --
    (see all 3)    		 --
    		 52(a)
    39(a)
    (see all 3)    		 1 ↔ many
    1 ↔ many
    (see all 3)    		 3(195846033-195847106)
    AAWZ02038436(4451-5581)
    zebrafish
    (Danio rerio)    		 Actinopterygii CT485993.16
    CABZ01086789.16
    		 --
    		 38(a)
    34(a)
    		 possible ortholog
    possible ortholog
    		 17(15480578-15481706)
    5(26911359-26912408)
    fruit fly
    (Drosophila melanogaster)    		 Insecta FucTA6
    		 FucTA
    		 16(a)
    		 1 ↔ 1
    		 3L(15140237-15147495)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 alpha-1,4-fucosyltransferase, putative, expressed
    		 12(a)
    		 1 ↔ 1
    		 4(21275947-21277506)


    ENSEMBL Gene Tree for FUT4 (if available)
    TreeFam Gene Tree for FUT4 (if available) 

    Paralogs
    for FUT4 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT4 gene
    FUT52  FUT72  FUT62  FUT32  FUT102  FUT112  FUT92  
    5 SIMAP similar genes for FUT4 using alignment to 1 protein entry:     FUT4_HUMAN:
    FUT5    FUT3    FUT6    FUT9    FUT7

    FUT4 for paralogs           About GeneDecksing



    Genomic Variants
    for FUT4 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/150 NCBI SNPs in FUT4 are shown (see all 150)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 11 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1171264601,2
    		F,--94275052(+) GAGATG/ACACAA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs754376681,2
    		--94275057(+) GCACAA/GTGATC 1 -- us2k13Minor allele frequency- G:0.05CSA WA 121
    rs1914094111,2
    		--94275083(+) CCAGCA/GATTTG 1 -- us2k10--------
    rs1144840531,2
    		C,F,--94275116(+) TCATCC/TAGACA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1839388011,2
    		--94275126(+) ACACCC/TTACTA 1 -- us2k10--------
    rs607124171,2
    		C,--94275299(+) GAAAAT/GCGGGA 1 -- us2k14Minor allele frequency- G:0.09WA NA EA 360
    rs1892069401,2
    		--94275320(+) GAAGCA/CATCAA 1 -- us2k10--------
    rs1378789181,2
    		--94275348(+) AAATGA/CCTACC 1 -- us2k10--------
    rs1437881841,2
    		C,--94275531(+) TTAAT-/TAAAAG
                TAAGA     		1 -- us2k10--------
    rs1494394221,2
    		--94275546(+) AGTGGA/GAAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FUT4 (94277017 - 94283064 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FUT4: --

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for FUT4

    Disorders / Diseases
    for FUT4 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FUT4 for disorders           About GeneDecksing

    OMIM gene information: 104230    OMIM disorders: --

    20/36 diseases for FUT4 (see all 36):    About MalaCards
    membranoproliferative glomerulonephritis    obstructive jaundice    acute promyelocytic leukemia    benign mesothelioma
    reticulosarcoma    atopic dermatitis    jaundice    malignant mesothelioma
    acute myeloid leukemia    intrahepatic cholangiocarcinoma    myeloid leukemia    colon adenocarcinoma
    inflammatory breast carcinoma    glomerulonephritis    colon carcinoma    teratoma
    myelodysplastic syndrome    embryonal carcinoma    colon cancer    dermatitis

    8 diseases from the University of Copenhagen DISEASES database for FUT4:
    Leukemia     Lymphoma     Teratoma     Embryonal carcinoma
    Carcinoma     Myeloid sarcoma     Teratocarcinoma     Benign mesothelioma

    9 Novoseek disease relationships for FUT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon adenocarcinoma 47.9 9 10873613 (5)
    colon cancer 36.9 1 9178808 (1)
    colon carcinoma 24.6 1 10211980 (1)
    gastric cancer 4.58 1 7630019 (1)
    leukemia 0 2 7693344 (1), 10873613 (1)
    cancer lung 0 2 8542587 (1), 10449611 (1)
    metastasis 0 3 16290306 (1), 17897065 (1), 10211980 (1)
    tumors 0 5 16290306 (1), 8542587 (1)
    cancer 0 4 7693344 (3), 9178808 (1)


    Export disorders for FUT4 gene to outside databases

    Publications
    for FUT4 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT4 gene, integrated from 9 sources (see all 150):
    (articles sorted by number of sources associating them with FUT4)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ELFT: a gene that directs the expression of an ELAM-1 ligand. (PubMed id 1702034)1, 2, 3, 9 Goelz S.E.... Lobb R. (1990)
    2. Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. (PubMed id 1716630)1, 2 Lowe J.B.... Ernst L.K. (1991)
    3. Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants. (PubMed id 1718983)1, 2 Kumar R.... Stanley P. (1991)
    4. Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis. (PubMed id 15182935)1, 9 Azuma Y....Matsumoto K. (2004)
    5. Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis. (PubMed id 17409497)1, 9 Azuma Y....Matsumoto K. (2007)
    6. Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line. (PubMed id 11006292)1, 9 Withers D.A. and Hakomori S.I. (2000)
    7. The micro-RNA 199b-5p regulatory circuit involves Hes1 , CD15, and epigenetic modifications in medulloblastoma. (PubMed id 22411914)1 Andolfo I....Zollo M. (2012)
    8. Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells. (PubMed id 22145955)1 Liu S....Yan Q. (2012)
    9. Differential fucosyltransferase IV expression in squam ous carcinoma cells is regulated by promoter methylation. (PubMed id 22287018)1 Li H....Wang X.Q. (2012)
    10. Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker. (PubMed id 22566498)1 Turner S.T....Boerwinkle E. (2012)

    External Searches for FUT4 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FUT4 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2526 HGNC: 4015 AceView: FUT4.1 Ensembl:ENSG00000196371 euGenes: HUgn2526
    ECgene: FUT4 Kegg: 2526 H-InvDB: FUT4

    Other Databases showing FUT4 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FUT4 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT4
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_601

    Intellectual Property
    for FUT4 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FUT4 gene:
    Search GeneIP for patents involving FUT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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