Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



FUT4 Gene

protein-coding   GIFtS: 58
GCID: GC11P094277

Fucosyltransferase 4 (Alpha (1,3) Fucosyltransferase, Myeloid-Specific)


(Previous symbols: CD15, FCT3A, ELFT)
  See FUT4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Fucosyltransferase 4 (Alpha (1,3) Fucosyltransferase,
Myeloid-Specific)1 2
     SSEA-12
FCT3A1 2 3 5     Alpha-(1,3)-Fucosyltransferase 42
ELFT1 2 3     fucT-IV2
Galactoside 3-L-Fucosyltransferase1 2 3     Lewis X2
CD151 2 5     Stage-Specific Embryonic Antigen 12
ELAM Ligand Fucosyltransferase1 2     EC 2.4.1.-3
Fucosyltransferase IV2 3     Fuc-TIV3
ELAM-1 Ligand Fucosyltransferase2 3     FucT-IV3
FUC-TIV2     Fucosyltransferase 43
FUTIV2     EC 2.4.18
LeX2     EC 2.4.1.658

External Ids:    HGNC: 40151   Entrez Gene: 25262   Ensembl: ENSG000001963717   OMIM: 1042305   UniProtKB: P220833   

Export aliases for FUT4 gene to outside databases

Previous GC identifers: GC11P096607 GC11P095784 GC11P094461 GC11P093965 GC11P093916 GC11P090342


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for FUT4 Gene:
The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated
carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). (provided by
RefSeq, Jan 2009)

GeneCards Summary for FUT4 Gene:
FUT4 (fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)) is a protein-coding gene. Diseases associated with FUT4 include myeloid sarcoma, and benign mesothelioma. GO annotations related to this gene include alpha-(1->3)-fucosyltransferase activity and fucosyltransferase activity. An important paralog of this gene is FUT5.

UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083
Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2
antigens




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_033899.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the FUT4 gene promoter:
         Pax-5   AP-1   ATF-2   CUTL1   Cdc5   C/EBPalpha   CP2   c-Jun   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUT4 promoter sequence
   Search Chromatin IP Primers for FUT4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUT4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q21   Ensembl cytogenetic band:  11q21   HGNC cytogenetic band: 11q21

FUT4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT4 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P094277:  view genomic region     (about GC identifiers)

Start:
94,277,017 bp from pter      End:
94,283,064 bp from pter
Size:
6,048 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083 (See protein sequence)
Recommended Name: Alpha-(1,3)-fucosyltransferase 4  
Size: 530 amino acids; 59084 Da
Caution: It is uncertain whether Met-1 or Met-126 is the initiator
Sequence caution: Sequence=AAB20349.1; Type=Frameshift; Positions=114;
Secondary accessions: B2RMS0

Explore the universe of human proteins at neXtProt for FUT4: NX_P22083

Explore proteomics data for FUT4 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn216, Asn315
  • Selected DME Specific Peptides for FUT4 (P22083) (see all 10)
     VPVVLGP  DWPPPWG  FIHVDDF  RFNISGC 


    See FUT4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002024.1  
    ENSEMBL proteins: 
     ENSP00000351602  

    FUT4 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FUT4
    OriGene Custom MassSpec
    OriGene Custom Protein Services for FUT4
    GenScript Custom Purified and Recombinant Proteins Services for FUT4
    Novus Biologicals FUT4 Protein
    Novus Biologicals FUT4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FUT4

     
    Search eBioscience for Proteins for FUT4 

     
    antibodies-online proteins for FUT4 (4 products) 

     
    antibodies-online peptides for FUT4

    FUT4 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of FUT4
    Browse R&D Systems for Antibodies
    OriGene Antibodies for FUT4
    OriGene Custom Antibody Services for FUT4
    Novus Biologicals FUT4 Antibodies
    Abcam antibodies for FUT4 (P51993, Q9Y231, Q11130, P22083, Q11128)
    Cloud-Clone Corp. Antibodies for FUT4
    ThermoFisher Antibody for FUT4
    antibodies-online antibodies for FUT4 (226 products) 

    FUT4 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for FUT4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for FUT4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FUT4
    Cloud-Clone Corp. CLIAs for FUT4
    Search eBioscience for ELISAs for FUT4 
    antibodies-online kits for FUT4 (19 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FUT: Fucosyltransferases
    CD: CD molecules

    1 InterPro protein domain:
     IPR001503 Glyco_trans_10

    Graphical View of Domain Structure for InterPro Entry P22083

    ProtoNet protein and cluster: P22083

    1 Blocks protein domain: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083
    Similarity: Belongs to the glycosyltransferase 10 family


    Find genes that share domains with FUT4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT4_HUMAN, P22083
    Function: May catalyze alpha-1,3 glycosidic linkages involved in the expression of Lewis X/SSEA-1 and VIM-2
    antigens

         Genatlas biochemistry entry for FUT4:
    fucosyltransferase,alpha-(1,3),4,(FucT-IV),myeloid;same as CD15

         Enzyme Numbers (IUBMB): EC 2.4.1.652 EC 2.4.12 EC 2.4.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008417fucosyltransferase activity TAS1716630
    GO:0046920alpha-(1->3)-fucosyltransferase activity TAS11698403
         
    Find genes that share ontologies with FUT4           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fut4):
     cardiovascular system  cellular  hematopoietic system  immune system 

    Find genes that share phenotypes with FUT4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fut4tm1Jbl for FUT4

       genOway: Develop your customized and physiologically relevant rodent model for FUT4

    miRNA
    Products:
        
    miRTarBase miRNAs that target FUT4:
    hsa-mir-199a-3p (MIRT006453)

    Block miRNA regulation of human, mouse, rat FUT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FUT4 (see all 40):
    hsa-miR-345 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-23a hsa-miR-642b hsa-miR-3622a-5p hsa-miR-4324
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FUT4
    Predesigned siRNA for gene silencing in human, mouse, rat FUT4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FUT4

    Clone
    Products:
         
    OriGene clones in human, mouse for FUT4 (see all 6)
    OriGene ORF clones in mouse, rat for FUT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FUT4 (NM_002033)
    Sino Biological Human cDNA Clone for FUT4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT4

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FUT4
    Browse ESI BIO Cell Lines and PureStem Progenitors for FUT4 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    FUT4_HUMAN, P22083: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
    Note=Membrane-bound form in trans cisternae of Golgi
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytoskeleton2
    extracellular2
    nucleus2
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    lysosome1
    mitochondrion1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS11698403
    GO:0009986cell surface IEA--
    GO:0016020membrane TAS1716630
    GO:0016021integral component of membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with FUT4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for FUT4 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Other types of O-glycan biosynthesis
    Other types of O-glycan biosynthesis
    3Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series


    Find genes that share SuperPaths with FUT4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    3 Kegg Pathways  (Kegg details for FUT4):
        Other types of O-glycan biosynthesis
    Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT4_HUMAN, P22083
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Array including FUT4: 

              Mesenchymal Stem Cell in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FUT4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for FUT4 (P220833 ENSP000003516024) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ITGB2P051073, ENSP000003032424I2D: score=2 STRING: ENSP00000303242
    CR1P179273, ENSP000003560164I2D: score=2 STRING: ENSP00000356016
    ISG15P051613, ENSP000003686994I2D: score=1 STRING: ENSP00000368699
    SELPP161093, ENSP000002636864I2D: score=2 STRING: ENSP00000263686
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS1716630
    GO:0006486protein glycosylation TAS11698403
    GO:0036065fucosylation TAS11698403
    GO:0042355L-fucose catabolic process NAS11698403

    Find genes that share ontologies with FUT4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FUT4

    Selected Novoseek inferred chemical compound relationships for FUT4 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp fucose 85.1 1 8925514 (1)
    n-acetyllactosamine 79.8 6 7591266 (1), 1490103 (1), 7528213 (1), 9461592 (1) (see all 5)
    polylactosamine 67 3 9461592 (2), 10622713 (1)
    tetrasaccharide 64.8 2 16199102 (1), 10211980 (1)
    l-fucose 52.4 1 8925514 (1)
    polysaccharide 48.1 2 16980970 (1), 9461592 (1)
    n-acetylglucosamine 47 2 1490103 (1), 8400824 (1)
    galactose 39.8 1 9648267 (1)
    glycolipid 37.4 2 10362832 (1), 7721776 (1)
    sialic acid 32.8 1 9461592 (1)



    Find genes that share compounds with FUT4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for FUT4 gene: 
    NM_002033.3  

    Unigene Clusters for FUT4:

    Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
    Hs.390420  [show with all ESTs], Hs.572064  [show with all ESTs]
    Unigene Representative Sequences: NM_002033, BC041922
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000358752(uc001pez.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat FUT4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FUT4 (see all 40):
    hsa-miR-345 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-23a hsa-miR-642b hsa-miR-3622a-5p hsa-miR-4324
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for FUT4
    Predesigned siRNA for gene silencing in human, mouse, rat FUT4
    Clone
    Products:
         
    OriGene clones in human, mouse for FUT4 (see all 6)
    OriGene ORF clones in mouse, rat for FUT4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FUT4 (NM_002033)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUT4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT4
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for FUT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FUT4
      QuantiTect SYBR Green Assays in human, mouse, rat FUT4
      QuantiFast Probe-based Assays in human, mouse, rat FUT4

    Additional mRNA sequence: BC041922.1 

    3 DOTS entries:

    DT.312151  DT.120701170  DT.308754 

    16 AceView cDNA sequences:

    BQ187068 BM718196 BM930393 BC041922 AI475919 BQ189767 BI522896 BI597047 
    AI796025 BE858128 BG897709 BI522712 BM930245 BF941734 AW028257 BF057407 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    FUT4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCAGATTTT
    FUT4 Expression
    About this image


    FUT4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Gonad
             Primordial Germ Cells Allantois
             Fetal Gonadal Stromal Cell
             Primordial germ-like cells
     
     Germ Cells (Reproductive System)    fully expand to see all 5 entries
             Primordial germ-like cells
     
     Spinal Cord (Nervous System)
             Neural stem cells
     
     Brain (Nervous System)
             Neural stem cells LewisX+ CXCR4+
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Myeloid Cells Hematopoietic Bone Marrow
             Enriched erythrocyte-like cells
    FUT4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FUT4 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.390420 Hs.572064
        Pathway & Disease-focused RT2 Profiler PCR Array including FUT4: 
              Mesenchymal Stem Cell in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for FUT4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FUT4
    QuantiTect SYBR Green Assays in human, mouse, rat FUT4
    QuantiFast Probe-based Assays in human, mouse, rat FUT4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for FUT4 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fut41 , 5 fucosyltransferase 41, 5 77.25(n)1
    74.82(a)1
      9 (4.30 cM)5
    143451  NM_010242.31  NP_034372.11 
     147484595 
    chicken
    (Gallus gallus)
    Aves FUT41 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, more 69.6(n)
    62.31(a)
      428092  NM_001031487.1  NP_001026658.1 
    lizard
    (Anolis carolinensis)
    Reptilia FUT46
    fucosyltransferase 4 (alpha (1,3) fucosyltransfera...
    55(a)
    1 ↔ 1
    3(195846033-195847106)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fut41 alpha3-fucosyltransferase 58.31(n)
    54.43(a)
      447974  NM_001004773.1  NP_001004773.1 


    ENSEMBL Gene Tree for FUT4 (if available)
    TreeFam Gene Tree for FUT4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for FUT4 gene
    FUT52  FUT72  FUT32  FUT62  FUT112  FUT102  FUT92  
    5 SIMAP similar genes for FUT4 using alignment to 1 protein entry:     FUT4_HUMAN:
    FUT5    FUT3    FUT6    FUT9    FUT7

    Find genes that share paralogs with FUT4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for FUT4 (see all 186)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486050371,2
    Cuntested194277852(+) CAACCC/GCGTCG 2 P A mis10--------
    rs1171264601,2
    C,F--94275052(+) GAGATG/ACACAA 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs754376681,2
    C,F--94275057(+) GCACAA/GTGATC 1 -- us2k13Minor allele frequency- G:0.05CSA WA 121
    rs1914094111,2
    --94275083(+) CCAGCA/GATTTG 1 -- us2k10--------
    rs1144840531,2
    C,F--94275116(+) TCATCC/TAGACA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1839388011,2
    --94275126(+) ACACCC/TTACTA 1 -- us2k10--------
    rs607124171,2
    C--94275299(+) GAAAAT/GCGGGA 1 -- us2k14Minor allele frequency- G:0.09WA NA EA 360
    rs1892069401,2
    --94275320(+) GAAGCA/CATCAA 1 -- us2k10--------
    rs1378789181,2
    --94275348(+) AAATGA/CCTACC 1 -- us2k10--------
    rs1437881841,2
    C--94275531(+) TTAAT-/TAAAAG
            
    TAAGA
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FUT4 (94277017 - 94283064 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FUT4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671948CNV Deletion23128226

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FUT4
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 104230    OMIM disorders: --

    5 diseases for FUT4:    
    About MalaCards
    myeloid sarcoma    benign mesothelioma    inflammatory breast carcinoma    colon adenocarcinoma
    acute promyelocytic leukemia

    8 diseases from the University of Copenhagen DISEASES database for FUT4:
    Leukemia     Lymphoma     Teratoma     Embryonal carcinoma
    Carcinoma     Benign mesothelioma     Myeloid sarcoma     Teratocarcinoma

    Find genes that share disorders with FUT4           About GenesLikeMe

    9 Novoseek inferred disease relationships for FUT4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon adenocarcinoma 47.9 9 10873613 (5)
    colon cancer 36.9 1 9178808 (1)
    colon carcinoma 24.6 1 10211980 (1)
    gastric cancer 4.58 1 7630019 (1)
    leukemia 0 2 7693344 (1), 10873613 (1)
    cancer lung 0 2 8542587 (1), 10449611 (1)
    metastasis 0 3 16290306 (1), 17897065 (1), 10211980 (1)
    tumors 0 5 16290306 (1), 8542587 (1)
    cancer 0 4 7693344 (3), 9178808 (1)


    Export disorders for FUT4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for FUT4 gene, integrated from 10 sources (see all 152):
    (articles sorted by number of sources associating them with FUT4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ELFT: a gene that directs the expression of an ELAM-1 ligand. (PubMed id 1702034)1, 2, 3, 9 Goelz S.E.... Lobb R. (Cell 1990)
    2. Molecular cloning of a human fucosyltransferase gene that determines expression of the Lewis x and VIM-2 epitopes but not ELAM-1-dependent cell adhesion. (PubMed id 1716630)1, 2 Lowe J.B.... Ernst L.K. (J. Biol. Chem. 1991)
    3. Cloning of a human alpha(1,3)-fucosyltransferase gene that encodes ELFT but does not confer ELAM-1 recognition on Chinese hamster ovary cell transfectants. (PubMed id 1718983)1, 2 Kumar R.... Stanley P. (J. Biol. Chem. 1991)
    4. Expression of cell surface Lewis X and Y antigens and FUT4 mRNA is increased in Jurkat cells undergoing apoptosis. (PubMed id 15182935)1, 9 Azuma Y....Matsumoto K. (Biochim. Biophys. Acta 2004)
    5. Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis. (PubMed id 17409497)1, 9 Azuma Y....Matsumoto K. (amp 2007)
    6. Human alpha (1,3)-fucosyltransferase IV (FUTIV) gene expression is regulated by elk-1 in the U937 cell line. (PubMed id 11006292)1, 9 Withers D.A. and Hakomori S.I. (J. Biol. Chem. 2000)
    7. Differential expression of E-cadherin, I^-catenin, and Lewis x between invasive hydatidiform moles and post-molar choriocarcinomas. (PubMed id 23681114)1 Candelier J.J....Coullin P. (Virchows Arch. 2013)
    8. Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells. (PubMed id 23799130)1 Gomes C....Reis C.A. (PLoS ONE 2013)
    9. The micro-RNA 199b-5p regulatory circuit involves Hes1, CD15, and epigenetic modifications in medulloblastoma. (PubMed id 22411914)1 Andolfo I....Zollo M. (Neuro-oncology 2012)
    10. Differential expression of LeY and fucosyltransferase IV correlates with the receptivity of RL95-2 and HEC-1A human uterine epithelial cells. (PubMed id 22145955)1 Liu S....Yan Q. (Cell Biol. Int. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2526 HGNC: 4015 AceView: FUT4.1 Ensembl:ENSG00000196371 euGenes: HUgn2526
    ECgene: FUT4 Kegg: 2526 H-InvDB: FUT4

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for FUT4 Pharmacogenomics, SNPs, Pathways
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT4
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_601

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for FUT4 gene:
    Search GeneIP for patents involving FUT4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of FUT4
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for FUT4   OriGene RNAi products in human, mouse, rat for FUT4  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for FUT4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for FUT4  
     OriGene qSTAR qPCR primer pairs in human, mouse for FUT4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for FUT4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for FUT4   OriGene Custom Protein Services for FUT4  

     
     
     Block miRNA regulation of human, mouse, rat FUT4 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing FUT4
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUT4 Predesigned siRNA for gene silencing in human, mouse, rat FUT4
     QuantiFast Probe-based Assays in human, mouse, rat FUT4 QuantiTect SYBR Green Assays in human, mouse, rat FUT4
     PCR Arrays including human, mouse, rat FUT4 Search Chromatin IP Primers for FUT4
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FUT4  Search GeneGlobe Interaction Network for FUT4
     Regulatory tfbs in FUT4 promoter
     GenScript Custom Purified and Recombinant Proteins Services for FUT4 GenScript cDNA clones with any tag delivered in your preferred vector for FUT4
     GenScript Custom Assay Services for FUT4 GenScript Custom overexpressing Cell Line Services for FUT4
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for FUT4
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for FUT4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     FUT4 antibodies
     FUT4 proteins
     FUT4 lysates
     Antibodies for FUT4
     See all of Abcam's Antibodies, Kits and Proteins for FUT4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for FUT4
     Antibodies for FUT4
     ELISAs for FUT4
     CLIAs for FUT4



     Browse ESI BIO Cell Lines and PureStem Progenitors for FUT4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for FUT4
     SwitchGear Promoter luciferase reporter plasmids for FUT4
     ThermoFisher Antibody for FUT4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT4
     Browse compounds at ApexBio
     Search Addgene for plasmids for FUT4
      Search eBioscience for proteins for FUT4
      Search eBioscience for elisas for FUT4
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for FUT4
     antibodies-online antibodies for FUT4 (226 products)
     antibodies-online kits for FUT4 (19 products)
     antibodies-online peptides for FUT4
     antibodies-online proteins for FUT4 (4 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      FUT4 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4