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FUT3 Gene

protein-coding GIFtS: 65

GC19M005793

fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
(Previous names: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: LE)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD174 ^¹, ²
EC 2.4.1.65 ^³
FT3B ^², ³
FucT-III ^², ³
LE ^², ³, ⁵
Les ^²
MGC131739 ^²
alpha-(1,3/1,4)-fucosyltransferase ^²

Descriptions
Blood group Lewis alpha-4-fucosyltransferase ^², ³
Fucosyltransferase 3 ^², ³
Fucosyltransferase III ^³
Lewis FT ^², ³
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group included) ^¹
fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) ^²
galactoside 3(4)-L-fucosyltransferase ^²

External Ids
HGNC: 4014¹
Entrez Gene: 2525²
UniProtKB: P21217³
Ensembl: ENSG00000171124⁷

Search outside databases for aliases for FUT3 gene

Previous GC identifers: GC19M005935 GC19M005782

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FUT3:

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are

synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids

function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial

adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype.

This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to

precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme

with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this

gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively

spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217

Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of

Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood

group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while

Lewis-negative (Le(-)) individuals have an inactive enzyme

Gene Wiki entry for FUT3 (Fucosyltransferase_3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FUT3 gene

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

FUT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M005793: (about GC identifiers)

Start:	5,793,899 bp from pter
End:	5,802,485 bp from pter
Size:	8,587 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011255.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217 (See protein sequence)

Recommended Name: Galactoside 3(4)-L-fucosyltransferase

Size: 361 amino acids; 42117 Da

Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Note=Membrane-bound form in trans cisternae of Golgi

Miscellaneous: Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl

links

Secondary accessions: B5U7U9 Q32NE7 Q99448 Q99449

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (4 alternative transcripts):

NP_000140.1 NP_001091108.1 NP_001091109.1 NP_001091110.1

ENSEMBL proteins:

ENSP00000305603 ENSP00000384749

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for FUT3 (Fucosyltransferase 3/FUT3)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (FUT3)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005624	membrane fraction	TAS	1977660
GO:0005794	Golgi apparatus	IEA	--
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for FUT3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for FUT3 (Fucosyltransferase 3/FUT3)
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Monoclonal and Polyclonal Antibodies from Abnova (FUT3)
	Novus Biologicals Antibody for FUT3

Assays for FUT3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P21217

ProtoNet protein and cluster: P21217

1 Blocks protein family: IPB001503 Glycosyl transferase

UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217

Similarity: Belongs to the glycosyltransferase 10 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FUT3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000149

Applied Biosystems Silencer® siRNAs for FUT3

Sigma-Aldrich siRNA for FUT3

Sigma-Aldrich shRNA for FUT3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FUT3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000149
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000149
untagged cDNA clones in CMV expression vector (see all 4): NM_000149

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001097640

UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217

Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of

Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood

group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while

Lewis-negative (Le(-)) individuals have an inactive enzyme

Catalytic activity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +

beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R

Enzyme Number (IUBMB): EC 2.4.1.65

Genatlas biochemistry entry for FUT3:

fucosyltransferase,alpha-(1,3,4),3 (FucT-III),Lewis blood group

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016757	transferase activity, transferring glycosyl groups	IEA	--
GO:0017060	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Sigma-Aldrich "Your Favorite Gene" Pathways for FUT3 (Your Favorite Gene powered by Ingenuity)

Glycosphingolipid Biosynthesis - Lactoseries
Glycosphingolipid Biosynthesis - Neolactoseries

GeneDecks FUT3 for the pathways selected above

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UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217

Pathway: Protein modification; protein glycosylation

5/27 Interacting proteins for FUT3 (ENSP00000305603³) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FUT1	ENSP00000312021³	STRING (score=.936)
ST3GAL6	ENSP00000265261³	STRING (score=.934)
B4GALT1	ENSP00000369055³	STRING (score=.931)
ST3GAL4	ENSP00000239597³	STRING (score=.922)
ABO	ENSP00000313515³	STRING (score=.921)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005975	carbohydrate metabolic process	TAS	1977660
GO:0006486	protein amino acid glycosylation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FUT3
7 Novoseek chemical compound relationships for FUT3 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
slea	79.77	4	7630015 (1), 12725333 (1)
slex	78.23	2	8785485 (1), 9756922 (1)
gdp fucose	76.55	1	2165495 (1)
tetrasaccharide	64.49	1	16199102 (1)
n-acetyllactosamine	54.96	1	7690713 (1)
glycolipid	37.24	1	7721776 (1)
glucose	0.00	1	10052591 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FUT3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_000149

Sigma-Aldrich siRNA for FUT3

Sigma-Aldrich shRNA for FUT3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000149 NM_001097639 NM_001097640 NM_001097641

REFSEQ mRNAs for FUT3 gene (4 alternative transcripts):

NM_000149.3 NM_001097639.1 NM_001097640.1 NM_001097641.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000149 NM_001097639 NM_001097640 NM_001097641

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_000149
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_000149
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_000149

Additional cDNA sequence:

AF131913.1 AK291852.1 AK313575.1 BC074836.2 BC074837.2 BC108675.1 U27326.1 U27327.1

U27328.1 X53578.1

8 DOTS entries:

DT.442297 DT.100746724 DT.121449811 DT.91743872 DT.95267684 DT.121449797 DT.121449801 DT.95345998

24/62 AceView cDNA sequences (see all 62 ):

BM768073 BM766846 BM743490 BM743864 BX281934 BM766905 AI720829 BM756780

BM767298 AL702924 BM770519 BM756710 BQ636368 BM748023 BM671165 BM770918

BM854511 BM756823 BM744294 AI271924 AW857376 AA876084 BM741856 BC074837

highest scoring ESTs for FUT3:

U27328 U27326 U27327 X53578 AA516474 AA601072 AA627734 AF131913 AI271924 AI720829

Unigene Cluster for FUT3:

Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)

Hs.169238 [show with all ESTs]

Unigene Representative Sequence: NM_000149

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000303225 ENST00000402214

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FUT3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FUT3

¹ / ² / ³

6 probe-sets matching FUT3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38495_s_at²^{, 3}	U95-A	1	1.00	1.00	0.92	1.04	U27328	1.00	1.00	1.00	1
36290_s_at²^{, 3}	U95-A	3	1.00	0.33	0.96	0.99	U27331	0.20	0.08	0.15	2
214088_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW080549	0.60	1.00	0.82	1
216010_x_at²	U133-A	5	1.00	0.35	--	--	--	--	--	--	--
214088_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216010_x_at²	U133Plus2	5	1.00	0.35	--	--	--	--	--	--	--

GeneDecks FUT3 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTGCCTGGGC

SOURCE GeneReport for Unigene cluster: Hs.169238
Expression variation in blood from EXPOLDB for FUT3
UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
Tissue specificity: Highly expressed in stomach, colon, small intestine, lung and kidney and to a
lesser extent in salivary gland, bladder, uterus and liver

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FUT3 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	FUT3¹	--	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, more	98.43(n) 98.61(a)	493975 NM_001009149.1 NP_001009149.1
chicken (Gallus gallus)	FUT3¹	--	fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, more	60.14(n) 51.75(a)	428341 XM_425901.1 XP_425901.1
fruit fly (Drosophila melanogaster)	FucTA³	71B6	protein amino acid glycosylation galactoside 3-L-fucosyltransferase	35(a) (best of 2)	--
worm (Caenorhabditis elegans)	fut-3¹	--	FUcosyl Transferase	42.84(n) 34.75(a)	173958 NM_062705.4 NP_495106.1

About this table Species with no ortholog for FUT3

ENSEMBL Gene Tree for FUT3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FUT3 gene

FUT4² FUT5² FUT7² FUT6² FUT9²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/225 NCBI SNPs in FUT3 are shown (see all 225 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 32)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs874232^1,2	A,C,F,H	5794609(-)	`CTGCTG/AGGGAC`	4	--	ut3¹ ese³		7	EA EU WA NS	1988
	rs2306969^1,2	A,C,F,H	5802801(+)	`GGGAGG/AGAAGT`	4	--	ng3¹ trp³		11	EA EU WA NS NA	2362
--	rs10406157^1,2	C,F,H	5803599(+)	`gtcctC/Tgccct`	4	--	ng3¹		6	EU EA WA NS	512
	rs778986^1,2	C,F,H	5795537(+)	`TGACCG/ATGTCT`	4	M/T	mis¹ ese³		14	EA NA MN EU WA NS	1166
	rs812936^1,2	C,F,H	5795649(+)	`TGTCCA/GTAGCA`	4	W/R	mis¹ ese³		12	EA EU WA NA NS	830
--	rs4807818^1,2	A,C,F	5804192(+)	`caaatG/Tgccag`	4	--	ng3¹		2	NS	88
--	rs11671428^1,2	A,C,F	5804113(+)	`caactC/Aacacc`	4	--	ng3¹		2	NS	88
--	rs10405209^1,2	A,C,F	5803854(+)	`cccttG/Agtgtt`	4	--	ng3¹		2	NS	86
--	rs10418972^1,2	A,C,F	5804145(+)	`ttattT/Ctgcaa`	4	--	ng3¹		2	NS	88
--	rs28742581^1,2	C,F	5803944(-)	`GGGTGA/-ATGAG`	4	--	ng3¹		2	NS	88

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HapMap Linkage Disequilibrium images for FUT3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 111100

10/11 Novoseek disease relationships for FUT3 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colon cancer	40.44	2	7630014 (1), 7630019 (1)
colon carcinoma	39.30	3	10747292 (1), 8909999 (1), 16199102 (1)
gastric cancer	27.10	3	11535550 (1), 7630019 (1), 16427187 (1)
carcinoma	1.81	1	9690558 (1)
necrosis	0.00	1	14727687 (1)
cancer lung	0.00	2	10449611 (2)
cancer	0.00	4	7693344 (2), 8943285 (1), 9178808 (1)
breast cancer	0.00	1	15196369 (1)
tumors	0.00	2	8943285 (1), 14727687 (1)
coronary heart disease	0.00	2	17383304 (1)

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Blood Group Antigen Gene Mutation Database (BGMUT) Lewis blood group system

Human Gene Mutation Database: FUT3
Genetic Association Database: FUT3
Human Genome Epidemiology Navigator: FUT3 (19 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/145 PubMed articles for FUT3 gene (see all 145 ):

A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. (PubMed id 1977660)^{2, 3, 4} Kukowska-Latallo J.F.... Lowe J.B. (1990)
Significance of individual point mutations, T202C and C314T, in the human Lewis 'FUT3' gene for expression of Lewis antigens by the human alpha'1,3/1,4'-fucosyltransferase, Fuc-TIII. (PubMed id 9268337)^{1, 3, 4} Elmgren A.... Larson G. (1997)
Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals. (PubMed id 8219240)^{1, 3, 4} Koda Y.... Mekada E. (1993)
Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody. (PubMed id 11535550)^{1, 3, 6} Ikehara Y....Tatematsu M. (2001)
Molecular genetic analysis of the human Lewis histo-blood group system. (PubMed id 7961897)^{1, 3, 4} Nishihara S.... Narimatsu I. (1994)
Five novel missense mutations of the Lewis gene 'FUT3' in African 'Xhosa' and Caucasian populations in South Africa. (PubMed id 9703429)^{1, 3, 4} Pang H.... Kimura H. (1998)
Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population. (PubMed id 12730721)^{1, 3, 6} Serpa J....David L. (2003)
Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PubMed id 7650030)^{1, 3, 4} Cameron H.S.... Weston B.W. (1995)
DNA sequencing and screening for point mutations in the human Lewis 'FUT3' gene enables molecular genotyping of the human Lewis blood group system. (PubMed id 8801770)^{1, 3, 4} Elmgren A.... Larson G. (1996)
Association of the Lewis genotype with cardiovascular risk factors and subclinical carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 14687237)^{1, 3, 6} Cakir B....Weston B.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2525	HGNC: 4014	AceView: FUT3	Ensembl:ENSG00000171124	euGenes: HUgn2525
ECgene: FUT3	H-InvDB: FUT3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=lewis
GGDB	http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT3
SeattleSNPs	http://pga.gs.washington.edu/data/fut3/
Functional Glycomics Gateway - GTase	http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_600

Licensable Technologies for FUT3
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FUT3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FUT3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FUT3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for FUT3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FUT3 Gene at Home site.
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FUT3 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for FUT3

Summaries
for FUT3

Genomic Location
for FUT3

Proteins
for FUT3

Protein Domains/
Families
for FUT3

Gene Function
for FUT3

Pathways & Interactions
for FUT3

Drugs & Compounds
for FUT3

Transcripts
for FUT3

Expression
for FUT3

Orthologs
for FUT3

Paralogs
for FUT3

SNPs/Variants
for FUT3

Disorders & Mutations
for FUT3

Medical News
for FUT3

Publications
for FUT3

Search for FUT3

Genome Databases showing FUT3

Other Databases showing FUT3

Specialized Databases showing FUT3

Licensable Technologies
for FUT3

Services
for FUT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FUT3 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor FUT3

Summariesfor FUT3

Genomic Locationfor FUT3

Proteinsfor FUT3

Protein Domains/Familiesfor FUT3

Gene Functionfor FUT3

Pathways & Interactionsfor FUT3

Drugs & Compoundsfor FUT3

Transcriptsfor FUT3

Expression for FUT3

Orthologsfor FUT3

Paralogsfor FUT3

SNPs/Variantsfor FUT3

Disorders & Mutationsfor FUT3

Medical Newsfor FUT3

Publicationsfor FUT3

Search for FUT3

Genome Databases showing FUT3

Other Databases showing FUT3

Specialized Databases showing FUT3

Licensable Technologiesfor FUT3

Servicesfor FUT3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FUT3

Summaries
for FUT3

Genomic Location
for FUT3

Proteins
for FUT3

Protein Domains/
Families
for FUT3

Gene Function
for FUT3

Pathways & Interactions
for FUT3

Drugs & Compounds
for FUT3

Transcripts
for FUT3

Expression
for FUT3

Orthologs
for FUT3

Paralogs
for FUT3

SNPs/Variants
for FUT3

Disorders & Mutations
for FUT3

Medical News
for FUT3

Publications
for FUT3

Licensable Technologies
for FUT3

Services
for FUT3