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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT3 Gene

protein-coding   GIFtS: 64
GCID: GC19M005843

fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase,...

(Previous names: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase,...)
(Previous symbol: LE)
 Explore 38 diseases affiliated with
FUT3 via our new
 Human Malady Compendium 
Biological research products
for FUT3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood
Group)1 2
     EC 2.4.1.653 8
LE1 2 3 5     Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group
Included)1
CD1741 2     Les2
Blood Group Lewis Alpha-4-Fucosyltransferase2 3     Alpha-(1,3/1,4)-Fucosyltransferase1
Fucosyltransferase III2 3     Galactoside 3(4)-L-Fucosyltransferase2
FT3B2 3     Fucosyltransferase 33
FucT-III2 3     EC 2.4.18
Lewis FT2 3     

External Ids:    HGNC: 40141   Entrez Gene: 25252   Ensembl: ENSG000001711247   OMIM: 1111005   UniProtKB: P212173   

Export aliases for FUT3 gene to outside databases

Previous GC identifers: GC19M005935 GC19M005782 GC19M005793 GC19M005602


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FUT3:
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine
epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue
differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood
cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes
the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an
enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are
responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding
the same protein, have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis
B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive
(Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts
on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links

Gene Wiki entry for FUT3 (Fucosyltransferase 3)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT3 gene promoter:
         c-Fos   CP2   AP-1   ATF-2   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FUT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005843:  view genomic region     (about GC identifiers)

Start:
5,842,899 bp from pter      End:
5,851,485 bp from pter
Size:
8,587 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217 (See protein sequence)
Recommended Name: Galactoside 3(4)-L-fucosyltransferase  
Size: 361 amino acids; 42117 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound
form in trans cisternae of Golgi
Secondary accessions: B5U7U9 B5U7V0 Q32NE7 Q99448 Q99449

Explore the universe of human proteins at neXtProt for FUT3: NX_P21217

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P21217

  • 4/17 DME Specific Peptides for FUT3 (P21217) (see all 17)
     VPVVLGP  LPPSPRP  CFFSYLR  FIHVDDF 

    FUT3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_000140.1  NP_001091108.1  NP_001091109.1  NP_001091110.1  

    ENSEMBL proteins: 
     ENSP00000416443   ENSP00000468123   ENSP00000305603   ENSP00000465804   ENSP00000467081  
     ENSP00000468515   ENSP00000467633   ENSP00000468795  

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    Novus Biologicals FUT3 Lysates
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    Uscn Proteins for FUT3

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IDA1977660
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--


    FUT3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FUT3 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001503 Glyco_trans_10

    Graphical View of Domain Structure for InterPro Entry P21217

    ProtoNet protein and cluster: P21217

    1 Blocks protein family: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Similarity: Belongs to the glycosyltransferase 10 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis
    B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive
    (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts
    on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links
    Catalytic activity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +
    beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R

         Genatlas biochemistry entry for FUT3:
    fucosyltransferase,alpha-(1,3,4),3 (FucT-III),Lewis blood group

    Enzyme Numbers (IUBMB): EC 2.4.1.651 2 EC 2.4.12

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008417fucosyltransferase activity IDA12668675
    GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA--
    GO:0046920alpha-(1->3)-fucosyltransferase activity IDA1977660


    FUT3 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FUT3:
     Synthetic lethal with Ras 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series1.00
    2Metabolism
    Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for FUT3):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Pathway: Protein modification; protein glycosylation


    FUT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/21 Interacting proteins for FUT3 (ENSP000003056034) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    B3GNT3ENSP000003218744STRING: ENSP00000321874
    B3GNT4ENSP000003196364STRING: ENSP00000319636
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--
    GO:0009312oligosaccharide biosynthetic process IDA1977660
    GO:0009988cell-cell recognition IC12668675
    GO:0036065fucosylation IDA12668675
    GO:0043413macromolecule glycosylation IDA12668675


    FUT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT3

    2 HMDB Compounds for FUT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    9 Novoseek chemical compound relationships for FUT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slea 79.5 4 7630015 (1), 12725333 (1)
    slex 77.6 2 8785485 (1), 9756922 (1)
    gdp fucose 75.8 1 2165495 (1)
    tetrasaccharide 63.7 1 16199102 (1)
    n-acetyllactosamine 54.2 1 7690713 (1)
    glycolipid 35.9 1 7721776 (1)
    glucose 0 1 10052591 (1)
    alanine 0 1 9057953 (1)
    cysteine 0 8 10816554 (2), 16387297 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FUT3 gene (4 alternative transcripts): 
    NM_000149.3  NM_001097639.1  NM_001097640.1  NM_001097641.1  

    Unigene Cluster for FUT3:

    Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
    Hs.169238  [show with all ESTs]
    Unigene Representative Sequence: NM_000149
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458379(uc002mdk.2) ENST00000589918 ENST00000303225(uc002mdm.2 uc002mdj.2 uc002mdl.2)
    ENST00000589620 ENST00000589714 ENST00000587048 ENST00000585715 ENST00000587183
    ENST00000593144 ENST00000588539

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    Additional cDNA sequence: 

    AF131913.1 AK291852.1 AK313575.1 BC074836.2 BC074837.2 BC108675.1 U27326.1 U27327.1 
    U27328.1 X53578.1 

    8 DOTS entries:

    DT.442297  DT.100746724  DT.91743872  DT.95267684  DT.121449811  DT.121449797  DT.121449801  DT.95345998 

    24/62 AceView cDNA sequences (see all 62):

    BM748023 BM756823 BM766905 BM770918 BX281934 BM743864 AL702924 AI720829 
    BM756710 BM767298 BM768073 BM854511 BM671165 BM766846 BM743490 BQ636368 
    BM756780 BM744294 BM770519 AI955644 BM741856 U27327 AL703506 BM744397 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTGCCTGGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FUT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT3

    SOURCE GeneReport for Unigene cluster: Hs.169238

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Tissue specificity: Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in
    salivary gland, bladder, uterus and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUT3 gene from 4/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves F1NTW7_CHICK6
    Q8UWB9_CHICK6
    (see all 3)
    Uncharacterized protein
    fucosyltransferase 7 (alpha (1,3) fucosyltransfera...
    (see all 3)
    47(a)
    35(a)
    (see all 3)
    possible ortholog
    1 ↔ many
    (see all 3)
    28(1106979-1108076)
    17(838136-839179)
    lizard
    (Anolis carolinensis)
    Reptilia FUT106
    --
    13(a)
    possible ortholog
    GL343339.1(1146655-1163889)
    zebrafish
    (Danio rerio)
    Actinopterygii CT485993.16
    CABZ01086789.16
    --
    37(a)
    34(a)
    possible ortholog
    possible ortholog
    17(15480578-15481706)
    5(26911359-26912408)
    fruit fly
    (Drosophila melanogaster)
    Insecta FucTA3
    FucTC1
    protein amino acid glycosylation galactoside
    3-L-fucosyltransferase3
    CG40305-PB1
    35(a)
    (best of 2)3
    26.54(n)1
    8.45999999999999(a)1
      71B63
    33551711  NM_001042855.31  NP_001036320.31 


    ENSEMBL Gene Tree for FUT3 (if available)
    TreeFam Gene Tree for FUT3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT3 gene
    FUT52  FUT42  FUT72  FUT62  FUT102  FUT112  FUT92  
    5 SIMAP similar genes for FUT3 using alignment to 9 protein entries:     FUT3_HUMAN (see all proteins):
    FUT5    FUT6    FUT9    FUT7    FUT4

    FUT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/394 NCBI SNPs in FUT3 are shown (see all 394    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs283624591,2
    C,F,pathogenic5604613(-) CGCACT/GGCTAT 8 /R /L mis1 ese312Minor allele frequency- G:0.15NS NA WA CSA EA EU 6143
    rs37456351,2
    C,F,pathogenic5844343(-) CCTACG/AGCTGG 8 /S /G mis19Minor allele frequency- A:0.10EA NS NA CSA EU 6693
    rs1423054621,2
    Cother5844674(+) GGGCGG/AGTGGG 8 /T syn11Minor allele frequency- A:0.00NA 3750
    rs283624571,2
    C,F,H,--5604981(-) AGCAAT/CGATGA 4 -- int17Minor allele frequency- C:0.01NS NA 602
    rs283624561,2
    C,--5605267(-) TTCTCA/C/GTGCCT 4 -- int12NS 76
    rs613854361,2
    C,--5605689(+) TTTTTT/AAAAAA 4 -- int11Minor allele frequency- A:0.50WA 2
    rs1128461611,2
    C,--5606221(+) ATAAAA/C/TAAACA 4 -- int12CSA WA 119
    rs287425921,2
    C,F,H,--5606316(-) TCATTT/GGAAAA 4 -- ut51 int16Minor allele frequency- G:0.03NS NA WA 410
    rs8096461,2
    C,F,H,--5606340(+) TGCTTT/CCTCTG 4 -- ut51 int111Minor allele frequency- C:0.01NS NA CSA WA 1172
    rs283624541,2
    C,F,H,--5606353(-) CAGTTC/TGGTCC 4 -- ut51 int17Minor allele frequency- T:0.04NS NA 696

    HapMap Linkage Disequilibrium report for FUT3 (5842899 - 5851485 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FUT3: --
    Human Gene Mutation Database (HGMD): FUT3

    Locus Specific Mutation Databases (LSDB): FUT3
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FUT3 for disorders           About GeneDecksing

    OMIM gene information: 111100    OMIM disorders: --

    20/38 diseases for FUT3 (see all 38):    About MalaCards
    transient global amnesia    fucosyltransferase deficiency    atrophic gastritis    hypertropia
    cystic fibrosis lung disease    peptic ulcer    penile cancer    cystic fibrosis
    cytomegalovirus infection    herpes simplex    inflammatory breast carcinoma    gastritis
    colon carcinoma    colon cancer    hepatitis c    gastric cancer
    lymphocytic leukemia    fibrosis    breast carcinoma    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for FUT3:
    Hypertropia

    10/11 Novoseek disease relationships for FUT3 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 41.7 2 7630014 (1), 7630019 (1)
    colon carcinoma 38.1 3 10747292 (1), 8909999 (1), 16199102 (1)
    gastric cancer 30 3 11535550 (1), 7630019 (1), 16427187 (1)
    carcinoma 0.398 1 9690558 (1)
    necrosis 0 1 14727687 (1)
    cancer lung 0 2 10449611 (2)
    breast cancer 0 1 15196369 (1)
    colorectal cancer 0 2 9178808 (1), 9690558 (1)
    tumors 0 2 8943285 (1), 14727687 (1)
    cancer 0 4 7693344 (2), 8943285 (1), 9178808 (1)

    Genetic Association Database (GAD): FUT3
    Human Genome Epidemiology (HuGE) Navigator: FUT3 (25 documents)

    Export disorders for FUT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT3 gene, integrated from 9 sources (see all 160):
    (articles sorted by number of sources associating them with FUT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. (PubMed id 1977660)1, 2, 3 Kukowska-Latallo J.F.... Lowe J.B. (1990)
    2. Significance of individual point mutations, T202C and C314T, in the human Lewis 'FUT3' gene for expression of Lewis antigens by the human alpha'1,3/1,4'-fucosyltransferase, Fuc-TIII. (PubMed id 9268337)1, 2, 9 Elmgren A.... Larson G. (1997)
    3. Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals. (PubMed id 8219240)1, 2, 9 Koda Y.... Mekada E. (1993)
    4. Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody. (PubMed id 11535550)1, 4, 9 Ikehara Y....Tatematsu M. (2001)
    5. Molecular genetic analysis of the human Lewis histo-blood group system. (PubMed id 7961897)1, 2, 9 Nishihara S.... Narimatsu I. (1994)
    6. Five novel missense mutations of the Lewis gene 'FUT3' in African 'Xhosa' and Caucasian populations in South Africa. (PubMed id 9703429)1, 2, 9 Pang H.... Kimura H. (1998)
    7. Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population. (PubMed id 12730721)1, 4, 9 Serpa J....David L. (2003)
    8. Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms. (PubMed id 7650030)1, 2, 9 Cameron H.S.... Weston B.W. (1995)
    9. DNA sequencing and screening for point mutations in the human Lewis 'FUT3' gene enables molecular genotyping of the human Lewis blood group system. (PubMed id 8801770)1, 2, 9 Elmgren A.... Larson G. (1996)
    10. Association of the Lewis genotype with cardiovascular risk factors and subclinical carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) study. (PubMed id 14687237)1, 4, 9 Cakir B....Weston B.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
    Disorders
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2525 HGNC: 4014 AceView: FUT3 Ensembl:ENSG00000171124 euGenes: HUgn2525
    ECgene: FUT3 Kegg: 2525 H-InvDB: FUT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT3 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=lewis
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT3
    SeattleSNPshttp://pga.gs.washington.edu/data/fut3/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_600

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FUT3 gene:
    Search GeneIP for patents involving FUT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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