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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT3 Gene

protein-coding   GIFtS: 66
GCID: GC19M005843

Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase,...

(Previous names: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase,...)
(Previous symbol: LE)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis
Blood Group)1 2
     Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood
Group Included)1
LE1 2 3 5     CD1742
Blood Group Lewis Alpha-4-Fucosyltransferase2 3     Les2
Fucosyltransferase III2 3     alpha-(1,3/1,4)-fucosyltransferase2
FT3B2 3     Galactoside 3(4)-L-Fucosyltransferase2
FucT-III2 3     Fucosyltransferase 33
Lewis FT2 3     EC 2.4.18
EC 2.4.1.653 8     

External Ids:    HGNC: 40141   Entrez Gene: 25252   Ensembl: ENSG000001711247   OMIM: 1111005   UniProtKB: P212173   

Export aliases for FUT3 gene to outside databases

Previous GC identifers: GC19M005935 GC19M005782 GC19M005793 GC19M005602


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FUT3 Gene:
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by
exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue
differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red
blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which
catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It
encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in
this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced
variants, encoding the same protein, have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FUT3 Gene: 
FUT3 (fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)) is a protein-coding gene. Diseases associated with FUT3 include inflammatory breast carcinoma, and penile cancer, and among its related super-pathways are Metabolism. GO annotations related to this gene include 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and fucosyltransferase activity. An important paralog of this gene is FUT5.

UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A,
Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination;
Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an
inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links

Gene Wiki entry for FUT3 (Fucosyltransferase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011255.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT3 gene promoter:
         c-Fos   CP2   AP-1   ATF-2   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUT3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FUT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005843:  view genomic region     (about GC identifiers)

Start:
5,842,899 bp from pter      End:
5,851,485 bp from pter
Size:
8,587 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217 (See protein sequence)
Recommended Name: Galactoside 3(4)-L-fucosyltransferase  
Size: 361 amino acids; 42117 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Note=Membrane-bound form in trans cisternae of Golgi
Secondary accessions: B5U7U9 B5U7V0 Q32NE7 Q99448 Q99449

Explore the universe of human proteins at neXtProt for FUT3: NX_P21217

Explore proteomics data for FUT3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P21217

  • 4/17 DME Specific Peptides for FUT3 (P21217) (see all 17)
     VPVVLGP  LPPSPRP  CFFSYLR  FIHVDDF 

    FUT3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FUT3 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_000140.1  NP_001091108.1  NP_001091109.1  NP_001091110.1  

    ENSEMBL proteins: 
     ENSP00000416443   ENSP00000468123   ENSP00000305603   ENSP00000465804   ENSP00000467081  
     ENSP00000468515   ENSP00000467633   ENSP00000468795  

    Human Recombinant Protein Products for FUT3: 
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    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for FUT3
    OriGene Custom MassSpec 
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    Novus Biologicals FUT3 Proteins
    Novus Biologicals FUT3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FUT3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IDA1977660
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--

    FUT3 for ontologies           About GeneDecksing



    FUT3 Antibody Products: 
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    ThermoFisher Antibodies for FUT3
    LSBio Antibodies in human, mouse, rat for FUT3 

    Assay Products for FUT3: 
    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FUT3 
    Cloud-Clone Corp. CLIAs for FUT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FUT: Fucosyltransferases
    CD: CD molecules
    bloodgroup: Blood group antigens

    1 InterPro protein domain:
     IPR001503 Glyco_trans_10

    Graphical View of Domain Structure for InterPro Entry P21217

    ProtoNet protein and cluster: P21217

    1 Blocks protein domain: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Similarity: Belongs to the glycosyltransferase 10 family


    FUT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT3_HUMAN, P21217
    Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A,
    Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination;
    Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an
    inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links
    Catalytic activity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +
    beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R

         Genatlas biochemistry entry for FUT3:
    fucosyltransferase,alpha-(1,3,4),3 (FucT-III),Lewis blood group

         Enzyme Numbers (IUBMB): EC 2.4.1.651 2 EC 2.4.12

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008417fucosyltransferase activity IDA12668675
    GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA--
    GO:0046920alpha-(1->3)-fucosyltransferase activity IDA1977660
         
    FUT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FUT3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FUT3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for FUT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FUT3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FUT3 

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidFUT3 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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    Sino Biological Human cDNA Clone for FUT3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT3
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                         Customized lentivirus expression plasmids for stable overexpression of FUT3 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FUT3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for FUT3):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Pathway: Protein modification; protein glycosylation


    FUT3 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/21 Interacting proteins for FUT3 (ENSP000003056034) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    B3GNT3ENSP000003218744STRING: ENSP00000321874
    B3GNT4ENSP000003196364STRING: ENSP00000319636
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--
    GO:0009312oligosaccharide biosynthetic process IDA1977660
    GO:0009988cell-cell recognition IC12668675
    GO:0036065fucosylation IDA12668675
    GO:0043413macromolecule glycosylation IDA12668675

    FUT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT3

    2 HMDB Compounds for FUT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    9 Novoseek inferred chemical compound relationships for FUT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slea 79.5 4 7630015 (1), 12725333 (1)
    slex 77.6 2 8785485 (1), 9756922 (1)
    gdp fucose 75.8 1 2165495 (1)
    tetrasaccharide 63.7 1 16199102 (1)
    n-acetyllactosamine 54.2 1 7690713 (1)
    glycolipid 35.9 1 7721776 (1)
    glucose 0 1 10052591 (1)
    alanine 0 1 9057953 (1)
    cysteine 0 8 10816554 (2), 16387297 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FUT3 gene (4 alternative transcripts): 
    NM_000149.3  NM_001097639.1  NM_001097640.1  NM_001097641.1  

    Unigene Cluster for FUT3:

    Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
    Hs.169238  [show with all ESTs]
    Unigene Representative Sequence: NM_000149
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458379(uc002mdk.2) ENST00000589918 ENST00000303225(uc002mdm.2 uc002mdj.2 uc002mdl.2)
    ENST00000589620 ENST00000589714 ENST00000587048 ENST00000585715 ENST00000587183
    ENST00000593144 ENST00000588539
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUT3
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUT3

    Additional mRNA sequence: 

    AF131913.1 AK291852.1 AK313575.1 BC074836.2 BC074837.2 BC108675.1 U27326.1 U27327.1 
    U27328.1 X53578.1 

    8 DOTS entries:

    DT.442297  DT.100746724  DT.91743872  DT.95267684  DT.121449811  DT.121449797  DT.121449801  DT.95345998 

    24/62 AceView cDNA sequences (see all 62):

    BM854511 BM756710 BM743490 AL702924 BM743864 BQ636368 BX281934 BM766905 
    BM756780 BM744294 BM770918 BM748023 BM756823 BM671165 BM768073 BM767298 
    BM766846 AI720829 BM770519 U27327 U27328 AL703506 NM_000149 AI271924 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCTGGGC
    FUT3 Expression
    About this image


    See FUT3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT3

    SOURCE GeneReport for Unigene cluster: Hs.169238

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Tissue specificity: Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in
    salivary gland, bladder, uterus and liver

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUT3 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia FUT56
    FUT56
    --
    66(a)
    66(a)
    many ↔ many
    many ↔ many
    20(54208840-54209892)
    20(54224690-54225841)
    chicken
    (Gallus gallus)
    Aves FUT36
    Uncharacterized protein
    45(a)
    1 → many
    28(1498656-1499789)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    1 → many
    AAWZ02038436(4451-5581)
    zebrafish
    (Danio rerio)
    Actinopterygii fut96
    --
    (see all 15)
    --
    35(a)
    35(a)
    (see all 15)
    many ↔ many
    many ↔ many
    (see all 15)
    8(3512976-3517595)
    8(3626455-3650896)
    fruit fly
    (Drosophila melanogaster)
    Insecta FucTA3
    FucTC1
    protein amino acid glycosylation
    galactoside 3-L-fucosyltransferase3
    CG40305-PB1
    35(a)
    (best of 2)3
    26.54(n)1
    8.45999999999999(a)1
      71B63
    33551711  NM_001042855.31  NP_001036320.31 


    ENSEMBL Gene Tree for FUT3 (if available)
    TreeFam Gene Tree for FUT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT3 gene
    FUT52  FUT42  FUT72  FUT62  FUT112  FUT102  FUT92  
    5 SIMAP similar genes for FUT3 using alignment to 9 protein entries:     FUT3_HUMAN (see all proteins):
    FUT5    FUT6    FUT9    FUT7    FUT4

    FUT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/458 SNPs in FUT3 are shown (see all 458)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37456351,2
    C,Fpathogenic15768782(-) CCTACG/AGCTGG 8 /S /G mis19Minor allele frequency- A:0.10EA NS NA CSA EU 6693
    rs283624591,2,4
    C,Fpathogenic15769231(-) CGCACT/GGCTAT 8 /R /L mis1 ese312Minor allele frequency- G:0.15NS NA WA CSA EA EU 6143
    rs1423054621,2
    Cuntested15769113(+) GGGCGG/AGTGGG 8 /T syn11Minor allele frequency- A:0.00NA 3750
    VAR_0034274
    ----see VAR_0034272 T M mis40--------
    VAR_0034294
    ----see VAR_0034292 D A mis40--------
    VAR_0079594
    ----see VAR_0079592 W R mis40--------
    VAR_0079614
    ----see VAR_0079612 S A mis40--------
    VAR_0034284
    ----see VAR_0034282 G S mis40--------
    rs1381200181,2
    C--5606190(+) TCTCA-/AAAT  
            
    AAATA
    4 -- int10--------
    rs1128461611,2
    C,F--5606221(+) ATAAAA/C/TAAACA 4 -- int12CSA WA 119

    HapMap Linkage Disequilibrium report for FUT3 (5842899 - 5851485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FUT3:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3694n71CNV Loss21882294
    dgv3693n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): FUT3

    Locus Specific Mutation Databases (LSDB): FUT3
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FUT3
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 111100    OMIM disorders: --

    20/31 diseases for FUT3 (see all 31):    About MalaCards
    inflammatory breast carcinoma    penile cancer    hypertropia    transient global amnesia
    atrophic gastritis    peptic ulcer    cytomegalovirus infection    gastritis
    cystic fibrosis    colon adenocarcinoma    gastric cancer    herpes simplex
    peritonitis    colon cancer    colorectal cancer    coronary heart disease
    liver disease    atherosclerosis    hepatitis c    asthma

    1 disease from the University of Copenhagen DISEASES database for FUT3:
    Hypertropia

    FUT3 for disorders           About GeneDecksing

    10/11 Novoseek inferred disease relationships for FUT3 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 41.7 2 7630014 (1), 7630019 (1)
    colon carcinoma 38.1 3 10747292 (1), 8909999 (1), 16199102 (1)
    gastric cancer 30 3 11535550 (1), 7630019 (1), 16427187 (1)
    carcinoma 0.398 1 9690558 (1)
    necrosis 0 1 14727687 (1)
    cancer lung 0 2 10449611 (2)
    breast cancer 0 1 15196369 (1)
    colorectal cancer 0 2 9178808 (1), 9690558 (1)
    tumors 0 2 8943285 (1), 14727687 (1)
    cancer 0 4 7693344 (2), 8943285 (1), 9178808 (1)

    Genetic Association Database (GAD): FUT3
    Human Genome Epidemiology (HuGE) Navigator: FUT3 (25 documents)

    Export disorders for FUT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT3 gene, integrated from 9 sources (see all 161):
    (articles sorted by number of sources associating them with FUT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. (PubMed id 1977660)1, 2, 3 Kukowska-Latallo J.F.... Lowe J.B. (1990)
    2. Significance of individual point mutations, T202C and C314T, in the human Lewis 'FUT3' gene for expression of Lewis antigens by the human alpha'1,3/1,4'-fucosyltransferase, Fuc-TIII. (PubMed id 9268337)1, 2, 9 Elmgren A.... Larson G. (1997)
    3. Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals. (PubMed id 8219240)1, 2, 9 Koda Y.... Mekada E. (1993)
    4. Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study. (PubMed id 17383304)1, 4, 9 Djousse L....Ellison R.C. (2007)
    5. Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody. (PubMed id 11535550)1, 4, 9 Ikehara Y....Tatematsu M. (2001)
    6. [FUT3 gene polymorphism associated with Lewis blood group in Chinese Zhejiang population] (PubMed id 16800951)1, 4, 9 Xu X.G....Yan L.X. (2006)
    7. Molecular genetic analysis of the human Lewis histo-blood group system. (PubMed id 7961897)1, 2, 9 Nishihara S.... Narimatsu I. (1994)
    8. Genetic variation of FUT3 in Ghanaians, Caucasians, and Mongolians. (PubMed id 19175549)1, 4, 9 Soejima M....Koda Y. (2009)
    9. Five novel missense mutations of the Lewis gene 'FUT3' in African 'Xhosa' and Caucasian populations in South Africa. (PubMed id 9703429)1, 2, 9 Pang H.... Kimura H. (1998)
    10. Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population. (PubMed id 12730721)1, 4, 9 Serpa J....David L. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2525 HGNC: 4014 AceView: FUT3 Ensembl:ENSG00000171124 euGenes: HUgn2525
    ECgene: FUT3 Kegg: 2525 H-InvDB: FUT3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT3 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=lewis
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT3
    SeattleSNPshttp://pga.gs.washington.edu/data/fut3/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_600

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FUT3 gene:
    Search GeneIP for patents involving FUT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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