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Aliases for FUT3 Gene

Aliases for FUT3 Gene

  • Fucosyltransferase 3 (Lewis Blood Group) 2 3 5
  • Blood Group Lewis Alpha-4-Fucosyltransferase 3 4
  • Fucosyltransferase III 3 4
  • EC 2.4.1.65 4 63
  • Lewis FT 3 4
  • FucT-III 3 4
  • FT3B 3 4
  • LE 3 4
  • Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group Included) 2
  • Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood Group) 3
  • Galactoside 3(4)-L-Fucosyltransferase 2
  • Alpha-(1,3/1,4)-Fucosyltransferase 3
  • Fucosyltransferase 3 4
  • EC 2.4.1 63
  • CD174 3
  • Les 3

External Ids for FUT3 Gene

Previous HGNC Symbols for FUT3 Gene

  • LE

Previous GeneCards Identifiers for FUT3 Gene

  • GC19M005935
  • GC19M005782
  • GC19M005793
  • GC19M005602

Summaries for FUT3 Gene

Entrez Gene Summary for FUT3 Gene

  • The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT3 Gene

FUT3 (Fucosyltransferase 3 (Lewis Blood Group)) is a Protein Coding gene. Diseases associated with FUT3 include inflammatory breast carcinoma and hypertropia. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include fucosyltransferase activity and 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT3 Gene

  • May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.

Gene Wiki entry for FUT3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT3 Gene

Genomics for FUT3 Gene

Regulatory Elements for FUT3 Gene

Genomic Location for FUT3 Gene

Chromosome:
19
Start:
5,842,888 bp from pter
End:
5,851,474 bp from pter
Size:
8,587 bases
Orientation:
Minus strand

Genomic View for FUT3 Gene

Genes around FUT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT3 Gene

Proteins for FUT3 Gene

  • Protein details for FUT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21217-FUT3_HUMAN
    Recommended name:
    Galactoside 3(4)-L-fucosyltransferase
    Protein Accession:
    P21217
    Secondary Accessions:
    • B5U7U9
    • B5U7V0
    • Q32NE7
    • Q99448
    • Q99449

    Protein attributes for FUT3 Gene

    Size:
    361 amino acids
    Molecular mass:
    42117 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FUT3 Gene

Proteomics data for FUT3 Gene at MOPED

Post-translational modifications for FUT3 Gene

  • Glycosylation at Asn 154 and Asn 185
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for FUT3 (Fucosyltransferase 3/5 (FUT3/5))
  • R&D Systems Antibodies for FUT3 (Fucosyltransferase 3/FUT3)

Domains & Families for FUT3 Gene

Protein Domains for FUT3 Gene

Graphical View of Domain Structure for InterPro Entry

P21217

UniProtKB/Swiss-Prot:

FUT3_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT3: view

Function for FUT3 Gene

Molecular function for FUT3 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,3,4),3 (FucT-III),Lewis blood group
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R.
UniProtKB/Swiss-Prot Function:
May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A, Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination; Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links.

Enzyme Numbers (IUBMB) for FUT3 Gene

genes like me logo Genes that share phenotypes with FUT3: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUT3 Gene

Localization for FUT3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT3 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT3 Gene COMPARTMENTS Subcellular localization image for FUT3 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
endosome 2
lysosome 2
nucleus 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for FUT3 Gene

Pathways & Interactions for FUT3 Gene

genes like me logo Genes that share pathways with FUT3: view

UniProtKB/Swiss-Prot P21217-FUT3_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT3 Gene

Gene Ontology (GO) - Biological Process for FUT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009312 oligosaccharide biosynthetic process IDA 1977660
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with FUT3: view

No data available for SIGNOR curated interactions for FUT3 Gene

Drugs & Compounds for FUT3 Gene

(3) Drugs for FUT3 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(8) Additional Compounds for FUT3 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT3: view

Transcripts for FUT3 Gene

Unigene Clusters for FUT3 Gene

Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT3 Gene

No ASD Table

Relevant External Links for FUT3 Gene

GeneLoc Exon Structure for
FUT3
ECgene alternative splicing isoforms for
FUT3

Expression for FUT3 Gene

mRNA expression in normal human tissues for FUT3 Gene

mRNA differential expression in normal tissues according to GTEx for FUT3 Gene

This gene is overexpressed in Esophagus - Mucosa (x16.3), Colon - Transverse (x11.2), Minor Salivary Gland (x6.9), Small Intestine - Terminal Ileum (x4.9), and Vagina (x4.5).

Protein differential expression in normal tissues from HIPED for FUT3 Gene

This gene is overexpressed in Nasal epithelium (59.7) and Saliva (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT3 Gene



SOURCE GeneReport for Unigene cluster for FUT3 Gene Hs.169238

mRNA Expression by UniProt/SwissProt for FUT3 Gene

P21217-FUT3_HUMAN
Tissue specificity: Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in salivary gland, bladder, uterus and liver.
genes like me logo Genes that share expression patterns with FUT3: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for FUT3 Gene

Orthologs for FUT3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT3 35
  • 98.43 (n)
  • 98.61 (a)
FUT3 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 66 (a)
OneToMany
dog
(Canis familiaris)
Mammalia FUT5 36
  • 66 (a)
ManyToMany
FUT5 36
  • 66 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
ManyToMany
-- 36
  • 51 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 45 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 48 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta FucTA 37
  • 35 (a)
FucTC 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea fut-3 35
  • 41.77 (n)
  • 33.43 (a)
Species with no ortholog for FUT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for FUT3 Gene

ENSEMBL:
Gene Tree for FUT3 (if available)
TreeFam:
Gene Tree for FUT3 (if available)

Paralogs for FUT3 Gene

Paralogs for FUT3 Gene

(5) SIMAP similar genes for FUT3 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with FUT3: view

Variants for FUT3 Gene

Sequence variations from dbSNP and Humsavar for FUT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs28362459 - 5,844,781(-) CGCAC(A/G/T)GCTAT reference, missense
rs778986 - 5,844,526(+) TGACC(A/G)TGTCT reference, missense
VAR_003428 -
VAR_003429 -
rs3894326 - 5,843,773(-) CAGCA(A/T)AGCGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FUT3 Gene

Variant ID Type Subtype PubMed ID
dgv3693n71 CNV Loss 21882294
dgv3694n71 CNV Loss 21882294

Variation tolerance for FUT3 Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.86; 91.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT3 Gene

HapMap Linkage Disequilibrium report
FUT3
Human Gene Mutation Database (HGMD)
FUT3
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT3 Gene

Disorders for FUT3 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FUT3 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
inflammatory breast carcinoma
  • inflammatory carcinoma of breast
hypertropia
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards
Search FUT3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT3

Genetic Association Database (GAD)
FUT3
Human Genome Epidemiology (HuGE) Navigator
FUT3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT3
genes like me logo Genes that share disorders with FUT3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT3 Gene

Publications for FUT3 Gene

  1. A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. (PMID: 1977660) Kukowska-Latallo J.F. … Lowe J.B. (Genes Dev. 1990) 2 3 4 67
  2. Genetic variation of FUT3 in Ghanaians, Caucasians, and Mongolians. (PMID: 19175549) Soejima M. … Koda Y. (Transfusion 2009) 3 23
  3. Identification of 14 new alleles at the fucosyltransferase 1, 2, and 3 loci in Styrian blood donors, Austria. (PMID: 19572973) Matzhold E.M. … Lanzer G. (Transfusion 2009) 3 23
  4. Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study. (PMID: 17383304) DjoussAc L. … Ellison R.C. (Am. Heart J. 2007) 3 23
  5. Expression of Lea in gastric cancer cell lines depends on FUT3 expression regulated by promoter methylation. (PMID: 16427187) Serpa J. … David L. (Cancer Lett. 2006) 3 23

Products for FUT3 Gene

Sources for FUT3 Gene

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