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FUT3 Gene

protein-coding   GIFtS: 66
GCID: GC19M005843

Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase,...

(Previous names: fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase,...)
(Previous symbol: LE)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis
Blood Group)1 2
     Fucosyltransferase 3 (Galactoside 3(4)-L-Fucosyltransferase, Lewis Blood
Group Included)1
LE1 2 3 5     CD1742
Blood Group Lewis Alpha-4-Fucosyltransferase2 3     Les2
Fucosyltransferase III2 3     alpha-(1,3/1,4)-fucosyltransferase2
FT3B2 3     Galactoside 3(4)-L-Fucosyltransferase2
FucT-III2 3     Fucosyltransferase 33
Lewis FT2 3     EC 2.4.18
EC 2.4.1.653 8     

External Ids:    HGNC: 40141   Entrez Gene: 25252   Ensembl: ENSG000001711247   OMIM: 1111005   UniProtKB: P212173   

Export aliases for FUT3 gene to outside databases

Previous GC identifers: GC19M005935 GC19M005782 GC19M005793 GC19M005602


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FUT3 Gene:
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by
exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue
differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red
blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which
catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It
encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in
this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced
variants, encoding the same protein, have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FUT3 Gene:
FUT3 (fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)) is a protein-coding gene. Diseases associated with FUT3 include inflammatory breast carcinoma, and hypertropia. GO annotations related to this gene include 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity and fucosyltransferase activity. An important paralog of this gene is FUT5.

UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A,
Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination;
Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an
inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links

Gene Wiki entry for FUT3 (Fucosyltransferase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the FUT3 gene promoter:
         c-Fos   CP2   AP-1   ATF-2   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUT3 promoter sequence
   Search Chromatin IP Primers for FUT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

FUT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M005843:  view genomic region     (about GC identifiers)

Start:
5,842,899 bp from pter      End:
5,851,485 bp from pter
Size:
8,587 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217 (See protein sequence)
Recommended Name: Galactoside 3(4)-L-fucosyltransferase  
Size: 361 amino acids; 42117 Da
Secondary accessions: B5U7U9 B5U7V0 Q32NE7 Q99448 Q99449

Explore the universe of human proteins at neXtProt for FUT3: NX_P21217

Explore proteomics data for FUT3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn154, Asn185
  • Selected DME Specific Peptides for FUT3 (P21217) (see all 17)
     VPVVLGP  LPPSPRP  CFFSYLR  FIHVDDF 


    See FUT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_000140.1  NP_001091108.1  NP_001091109.1  NP_001091110.1  

    ENSEMBL proteins: 
     ENSP00000416443   ENSP00000468123   ENSP00000305603   ENSP00000465804   ENSP00000467081  
     ENSP00000468515   ENSP00000467633   ENSP00000468795  

    FUT3 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FUT: Fucosyltransferases
    CD: CD molecules
    bloodgroup: Blood group antigens

    1 InterPro protein domain:
     IPR001503 Glyco_trans_10

    Graphical View of Domain Structure for InterPro Entry P21217

    ProtoNet protein and cluster: P21217

    1 Blocks protein domain: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Similarity: Belongs to the glycosyltransferase 10 family


    FUT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT3_HUMAN, P21217
    Function: May catalyze alpha-1,3 and alpha-1,4 glycosidic linkages involved in the expression of Vim-2, Lewis A,
    Lewis B, sialyl Lewis X and Lewis X/SSEA-1 antigens. May be involved in blood group Lewis determination;
    Lewis-positive (Le(+)) individuals have an active enzyme while Lewis-negative (Le(-)) individuals have an
    inactive enzyme. Also acts on the corresponding 1,4-galactosyl derivative, forming 1,3-L-fucosyl links
    Catalytic activity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-D-glucosaminyl-R = GDP +
    beta-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->4))-N-acetyl-beta-D-glucosaminyl-R

         Genatlas biochemistry entry for FUT3:
    fucosyltransferase,alpha-(1,3,4),3 (FucT-III),Lewis blood group

         Enzyme Numbers (IUBMB): EC 2.4.1.651 2 EC 2.4.12

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008417fucosyltransferase activity IDA12668675
    GO:00170603-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity IEA--
    GO:0046920alpha-(1->3)-fucosyltransferase activity IDA1977660
         
    FUT3 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for FUT3:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FUT3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FUT3
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    Sino Biological Human cDNA Clone for FUT3
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FUT3_HUMAN, P21217: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
    Note=Membrane-bound form in trans cisternae of Golgi
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    endosome2
    extracellular2
    nucleus2
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016020membrane IDA1977660
    GO:0016021integral component of membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    FUT3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FUT3 About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38
    2Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2 Kegg Pathways  (Kegg details for FUT3):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Pathway: Protein modification; protein glycosylation


    FUT3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FUT3
    Interactions:

        Search GeneGlobe Interaction Network for FUT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for FUT3 (ENSP000003056034) via UniProtKB, MINT, STRING, and/or I2D (see all 21)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT2ENSP000003564044STRING: ENSP00000356404
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    B3GNT3ENSP000003218744STRING: ENSP00000321874
    B3GNT4ENSP000003196364STRING: ENSP00000319636
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006486protein glycosylation IEA--
    GO:0009312oligosaccharide biosynthetic process IDA1977660
    GO:0009988cell-cell recognition IC12668675
    GO:0036065fucosylation IDA12668675
    GO:0043413macromolecule glycosylation IDA12668675

    FUT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FUT3

    2 HMDB Compounds for FUT3    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    9 Novoseek inferred chemical compound relationships for FUT3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    slea 79.5 4 7630015 (1), 12725333 (1)
    slex 77.6 2 8785485 (1), 9756922 (1)
    gdp fucose 75.8 1 2165495 (1)
    tetrasaccharide 63.7 1 16199102 (1)
    n-acetyllactosamine 54.2 1 7690713 (1)
    glycolipid 35.9 1 7721776 (1)
    glucose 0 1 10052591 (1)
    alanine 0 1 9057953 (1)
    cysteine 0 8 10816554 (2), 16387297 (1)



    FUT3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FUT3 gene (4 alternative transcripts): 
    NM_000149.3  NM_001097639.1  NM_001097640.1  NM_001097641.1  

    Unigene Cluster for FUT3:

    Fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group)
    Hs.169238  [show with all ESTs]
    Unigene Representative Sequence: NM_000149
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000458379(uc002mdk.2) ENST00000589918 ENST00000303225(uc002mdm.2 uc002mdj.2 uc002mdl.2)
    ENST00000589620 ENST00000589714 ENST00000587048 ENST00000585715 ENST00000587183
    ENST00000593144 ENST00000588539
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    Additional mRNA sequence: 

    AF131913.1 AK291852.1 AK313575.1 BC074836.2 BC074837.2 BC108675.1 U27326.1 U27327.1 
    U27328.1 X53578.1 

    8 DOTS entries:

    DT.442297  DT.100746724  DT.91743872  DT.95267684  DT.121449811  DT.121449797  DT.121449801  DT.95345998 

    Selected AceView cDNA sequences (see all 62):

    BM854511 BM756710 AI720829 BM756823 AL702924 BX281934 BM671165 BM766905 
    BM756780 BM770918 BM767298 BM770519 BM743864 BM744294 BQ636368 BM766846 
    BM743490 BM748023 BM768073 X53578 BM744397 BV198711 BC074837 CB851739 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FUT3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGCCTGGGC
    FUT3 Expression
    About this image

    FUT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FUT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.169238

    UniProtKB/Swiss-Prot: FUT3_HUMAN, P21217
    Tissue specificity: Highly expressed in stomach, colon, small intestine, lung and kidney and to a lesser extent in
    salivary gland, bladder, uterus and liver

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FUT3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia FUT56
    FUT56
    Uncharacterized protein
    Canis lupus familiaris fucosyltransferase 5 (alpha...
    66(a)
    66(a)
    many ↔ many
    many ↔ many
    20(54208840-54209892)
    20(54224690-54225841)
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    45(a)
    1 → many
    28(1498656-1499789)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    48(a)
    1 → many
    AAWZ02038436(4451-5581)
    worm
    (Caenorhabditis elegans)
    Secernentea fut-31 fut-3 41.77(n)
    33.43(a)
      173958  NM_062705.7  NP_495106.1 


    ENSEMBL Gene Tree for FUT3 (if available)
    TreeFam Gene Tree for FUT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FUT3 gene
    FUT52  FUT42  FUT72  FUT62  FUT112  FUT102  FUT92  
    5 SIMAP similar genes for FUT3 using alignment to 9 protein entries:     FUT3_HUMAN (see all proteins):
    FUT5    FUT6    FUT9    FUT7    FUT4

    FUT3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FUT3 (see all 458)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37456351,2
    C,Fpathogenic15768782(-) CCTACG/AGCTGG 8 /S /G mis19Minor allele frequency- A:0.10EA NS NA CSA EU 6693
    rs283624591,2,,4
    C,Fpathogenic15769231(-) CGCACT/GGCTAT 8 /R /L mis1 ese312Minor allele frequency- G:0.15NS NA WA CSA EA EU 6143
    rs1423054621,2
    Cuntested15769113(+) GGGCGG/AGTGGG 8 /T syn11Minor allele frequency- A:0.00NA 3750
    rs1381200181,2
    C--5606190(+) TCTCA-/AAAT  
            
    AAATA
    4 -- int10--------
    rs1128461611,2
    C,F--5606221(+) ATAAAA/C/TAAACA 4 -- int12CSA WA 119
    rs746638211,2
    C,F--5767026(+) ACAGGC/TGTGAC 4 -- ds50011Minor allele frequency- T:0.09EA 120
    rs1478856151,2
    --5767096(+) AAACCG/TGAGTG 4 -- ds50010--------
    rs1844501561,2
    --5767101(+) GGAGTA/GCAGTG 4 -- ds50010--------
    rs1887641601,2
    --5767157(+) ATCCTA/CCTGCC 4 -- ds50010--------
    rs562243441,2
    F--5767283(-) GATCAC/TGAGGT 4 -- ds50010--------

    HapMap Linkage Disequilibrium report for FUT3 (5842899 - 5851485 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FUT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3694n71CNV Loss21882294
    dgv3693n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): FUT3
    Locus Specific Mutation Databases (LSDB): FUT3

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FUT3
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 111100    OMIM disorders: --

    Selected diseases for FUT3 (see all 32):    
    About MalaCards
    inflammatory breast carcinoma    hypertropia    transient global amnesia    atrophic gastritis
    peptic ulcer    cytomegalovirus infection    gastritis    coronary heart disease
    colon adenocarcinoma    herpes simplex    peritonitis    colorectal cancer
    cystic fibrosis    hepatitis c virus    liver disease    hepatitis c
    atherosclerosis    asthma    obesity    schizophrenia

    1 disease from the University of Copenhagen DISEASES database for FUT3:
    Hypertropia

    FUT3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for FUT3 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 41.7 2 7630014 (1), 7630019 (1)
    colon carcinoma 38.1 3 10747292 (1), 8909999 (1), 16199102 (1)
    gastric cancer 30 3 11535550 (1), 7630019 (1), 16427187 (1)
    carcinoma 0.398 1 9690558 (1)
    necrosis 0 1 14727687 (1)
    cancer lung 0 2 10449611 (2)
    breast cancer 0 1 15196369 (1)
    colorectal cancer 0 2 9178808 (1), 9690558 (1)
    tumors 0 2 8943285 (1), 14727687 (1)
    cancer 0 4 7693344 (2), 8943285 (1), 9178808 (1)

    Genetic Association Database (GAD): FUT3
    Human Genome Epidemiology (HuGE) Navigator: FUT3 (25 documents)

    Export disorders for FUT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FUT3 gene, integrated from 10 sources (see all 163):
    (articles sorted by number of sources associating them with FUT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase. (PubMed id 1977660)1, 2, 3 Kukowska-Latallo J.F.... Lowe J.B. (Genes Dev. 1990)
    2. Significance of individual point mutations, T202C and C314T, in the human Lewis 'FUT3' gene for expression of Lewis antigens by the human alpha'1,3/1,4'-fucosyltransferase, Fuc-TIII. (PubMed id 9268337)1, 2, 9 Elmgren A.... Larson G. (J. Biol. Chem. 1997)
    3. Analysis of Lewis fucosyltransferase genes from the human gastric mucosa of Lewis-positive and -negative individuals. (PubMed id 8219240)1, 2, 9 Koda Y.... Mekada E. (Blood 1993)
    4. Fucosyltransferase 3 polymorphism and atherothrombotic disease in the Framingham Offspring Study. (PubMed id 17383304)1, 4, 9 DjoussAc L....Ellison R.C. (Am. Heart J. 2007)
    5. Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody. (PubMed id 11535550)1, 4, 9 Ikehara Y....Tatematsu M. (amp 2001)
    6. [FUT3 gene polymorphism associated with Lewis blood group in Chinese Zhejiang population]. (PubMed id 16800951)1, 4, 9 Xu X.G....Yan L.X. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006)
    7. Molecular genetic analysis of the human Lewis histo-blood group system. (PubMed id 7961897)1, 2, 9 Nishihara S.... Narimatsu I. (J. Biol. Chem. 1994)
    8. Genetic variation of FUT3 in Ghanaians, Caucasians, and Mongolians. (PubMed id 19175549)1, 4, 9 Soejima M....Koda Y. (Transfusion 2009)
    9. Five novel missense mutations of the Lewis gene 'FUT3' in African 'Xhosa' and Caucasian populations in South Africa. (PubMed id 9703429)1, 2, 9 Pang H.... Kimura H. (Hum. Genet. 1998)
    10. Lewis enzyme (alpha1-3/4 fucosyltransferase) polymorphisms do not explain the Lewis phenotype in the gastric mucosa of a Portuguese population. (PubMed id 12730721)1, 4, 9 Serpa J....David L. (J. Hum. Genet. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2525 HGNC: 4014 AceView: FUT3 Ensembl:ENSG00000171124 euGenes: HUgn2525
    ECgene: FUT3 Kegg: 2525 H-InvDB: FUT3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FUT3 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=lewis
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT3
    SeattleSNPshttp://pga.gs.washington.edu/data/fut3/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_600

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FUT3 gene:
    Search GeneIP for patents involving FUT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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