Aliases for FUT2 Gene
External Ids for FUT2 Gene
Previous HGNC Symbols for FUT2 Gene
Previous GeneCards Identifiers for FUT2 Gene
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for FUT2 Gene
FUT2 (Fucosyltransferase 2) is a Protein Coding gene. Diseases associated with FUT2 include Plasmacytic Leukemia and Staphyloenterotoxemia. Among its related pathways are Glycosphingolipid biosynthesis - globo series and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT1.
UniProtKB/Swiss-Prot for FUT2 Gene
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.