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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT2 Gene

protein-coding   GIFtS: 62
GCID: GC19P049199

fucosyltransferase 2 (secretor status included)


(Previous symbol: SE)
 Explore 39 diseases affiliated with
FUT2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for FUT2    

Aliases
for FUT2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Fucosyltransferase 2 (Secretor Status Included)1 2     EC 2.4.1.693 8
SEC21 2 3     B12QTL12 5
SE1 2 5     Alpha (1,2) Fucosyltransferase2
Se21 2     Alpha(1,2)FT21
Sej1     Galactoside 2-Alpha-L-Fucosyltransferase 22
Alpha(1,2)FT 22 3     SE23
Secretor Blood Group Alpha-2-Fucosyltransferase2 3     Se3
Secretor Factor2 3     Fucosyltransferase 23
GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 22 3     

External Ids:    HGNC: 40131   Entrez Gene: 25242   Ensembl: ENSG000001769207   OMIM: 1821005   UniProtKB: Q109813   

Export aliases for FUT2 gene to outside databases

Previous GC identifers: GC19P049896 GC19P049551 GC19P053859 GC19P053875 GC19P053869 GC19P045578


Summaries
for FUT2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for FUT2:
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of
the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one
of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have
been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
Function: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an
essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate
the same acceptor substrates but exhibit different Km values

Gene Wiki entry for FUT2


Genomic Views
for FUT2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT2 gene promoter:
         AhR   Elk-1   Tal-1   p53   LCR-F1   E47   SRY   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FUT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

FUT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049199:  view genomic region     (about GC identifiers)

Start:
 49,199,228 bp from pter      End:
 49,209,207 bp from pter
Size:
 9,980 bases      Orientation:
 plus strand

Proteins
for FUT2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981 (See protein sequence)
Recommended Name: Galactoside 2-alpha-L-fucosyltransferase 2  
Size: 343 amino acids; 39017 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound
form in trans cisternae of Golgi
Miscellaneous: There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed
in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively
Sequence caution: Sequence=BAA11638.1; Type=Erroneous initiation;
Secondary accessions: Q0VAG5 Q14338 Q5D0G2
Alternative initiation: 2 isoforms:  Q10981-1   Q10981-2   

Explore the universe of human proteins at neXtProt for FUT2: NX_Q10981

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q10981

    • 4/23 DME Specific Peptides for FUT2 (Q10981) (see all 23)
     GMWTINA  EFTLHDH  LAPIFRI  AAFLPEW 

    FUT2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_000502.4  NP_001091107.1  

    ENSEMBL proteins: 
     ENSP00000430227   ENSP00000387498   ENSP00000375748  

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    Novus Biologicals FUT2 Proteins
    Novus Biologicals FUT2 Lysates
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FUT2

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS11698403
    GO:0016020membrane ----
    GO:0030173integral to Golgi membrane NAS--
    GO:0032580Golgi cisterna membrane IEA--


    FUT2 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for FUT2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    FUT2 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002516 Glyco_trans_11

    Graphical View of Domain Structure for InterPro Entry Q10981

    ProtoNet protein and cluster: Q10981

    1 Blocks protein family: IPB002516 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Similarity: Belongs to the glycosyltransferase 11 family


    Function
    for FUT2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Function: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an
    essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate
    the same acceptor substrates but exhibit different Km values
    Catalytic activity: GDP-beta-L-fucose +
    beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
    = GDP +
    alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

         Genatlas biochemistry entry for FUT2:
    fucosyltransferase,alpha-(1,2),2,type I (secretor status)

    Enzyme Number (IUBMB): EC 2.4.1.691 2

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008107galactoside 2-alpha-L-fucosyltransferase activity TAS11698403
    GO:0008417fucosyltransferase activity TAS7876235


    FUT2 for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Fut2):
     digestive/alimentary  immune system  reproductive system 

    FUT2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for FUT2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Glycosphingolipid biosynthesis - lacto and neolacto series
    		Glycosphingolipid biosynthesis - lacto and neolacto series1.00
    2Glycosphingolipid biosynthesis - globo series
    		Glycosphingolipid biosynthesis - globo series1.00
    3Metabolism
    		Metabolic pathways0.38

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    3         Kegg Pathways  (Kegg details for FUT2):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - globo series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Pathway: Protein modification; protein glycosylation


    FUT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for FUT2 (ENSP000003757484) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT1ENSP000003037404STRING: ENSP00000303740
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    B3GNT2ENSP000003055954STRING: ENSP00000305595
    B3GNT4ENSP000003196364STRING: ENSP00000319636
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS7876235
    GO:0006486protein glycosylation TAS11698403
    GO:0036065fucosylation TAS7876235
    GO:0042355L-fucose catabolic process NAS11698403


    FUT2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for FUT2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FUT2

    2 HMDB Compounds for FUT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    2 Novoseek chemical compound relationships for FUT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbohydrates 27.4 6 18271619 (3), 10669366 (1), 18357756 (1), 19522218 (1)
    galactose 17.8 1 9287311 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT2 

    Transcripts
    for FUT2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for FUT2 gene (2 alternative transcripts): 
    NM_000511.5  NM_001097638.2  

    Unigene Clusters for FUT2:

    Fucosyltransferase 2 (secretor status included)
    Hs.579928  [show with all ESTs], Hs.655052  [show with all ESTs]
    Unigene Representative Sequences: NM_000511, BC080570
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522966 ENST00000425340(uc002pke.4 uc010emc.3) ENST00000522283
    ENST00000391876

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    hsa-miR-1301
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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: 

    BC080570.1 BT006657.1 

    6 DOTS entries:

    DT.92417557  DT.92012259  DT.97806164  DT.121503292  DT.121503296  DT.121503299 

    6 AceView cDNA sequences:

    D87946 NM_000511 D87947 BC001899 D87942 BT006657 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FUT2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for FUT2

    Expression
    for FUT2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAGTTGGGTA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    FUT2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See FUT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT2

    SOURCE GeneReport for Unigene clusters: Hs.579928 Hs.655052

    UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Tissue specificity: Small intestine, colon and lung

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    In Situ
    Assay Products:     
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    Orthologs
    for FUT2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for FUT2 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 59(a)
    		 1 → many
    		 GL343329.1(853192-856474)
    African clawed frog
    (Xenopus laevis)    		 Amphibia fut12 alpha2-fucosyltransferase 76.85(n)    AJ575933.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 26(a)
    		 1 → many
    		 Group15.8(976619-977697)


    ENSEMBL Gene Tree for FUT2 (if available)
    TreeFam Gene Tree for FUT2 (if available) 

    Paralogs
    for FUT2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT2 gene
    FUT12  
    4 SIMAP similar genes for FUT2 using alignment to 8 protein entries:     FUT2_HUMAN (see all proteins):
    sej    FUT1    h2    h1

    FUT2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FUT2
    PGOHUM00000250611


    Genomic Variants
    for FUT2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Polymorphism: Three alleles have been identified in the Japanese population: Se1, Se2, and Sej
    Polymorphism: Common polymorphisms in FUT2 define the vitamin B12 plasma level quantitative trait locus 1 (B12QTL1)
    [MIM:612542]. Vitamin B12 found in meat and milk products is necessary for the formation of red blood cells, DNA
    synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in
    vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodegenerative
    disorders, is often related to poor intestinal B12 absorption rather than direct dietary deficiency


    10/305 NCBI SNPs in FUT2 are shown (see all 305)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 19 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs10477811,2
    		C,F,H,non-pathogenic48376744(+) GCCACA/TTCCCG 4 I F mis1 ese313Minor allele frequency- T:0.03MN NA NS EA 5080
    rs6013381,2
    		C,F,A,H,pathogenic49206674(+) CTCCTG/AGACCT 4 /* /W stg124Minor allele frequency- A:0.45NS EA NA WA CSA EU 7298
    rs126088541,2
    		H--45576185(+) cccagC/Ttaatt 2 -- us2k10--------
    rs287461791,2
    		C,F,--45576500(+) GCTCCG/ACCCCC 2 -- us2k12Minor allele frequency- A:0.02NS 90
    rs25484561,2
    		C,F,A,--45576589(+) tttttT/Atatat 2 -- us2k1 trp32Minor allele frequency- A:0.13NS 92
    rs283628261,2
    		C,F,--45576612(+) GAGACG/AGGGTT 2 -- us2k13Minor allele frequency- A:0.03NS NA 94
    rs283628271,2
    		C--45576822(+) GTCCTG/ATGGAC 2 -- us2k14Minor allele frequency- A:0.01NS NA 98
    rs118824071,2
    		C,F,H--45576867(+) catggT/Ggtcgt 2 -- us2k15Minor allele frequency- G:0.00NS EA NA 424
    rs739423071,2
    		C,--45576893(+) GTCCTC/ACTGTT 2 -- us2k12Minor allele frequency- A:0.05WA 120
    rs762922561,2
    		C,--45577019(+) GGCTGC/GTGGTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FUT2 (49199228 - 49209207 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for FUT2
         3 CNVs: 50190 38387 32261
    Human Gene Mutation Database (HGMD): FUT2

    Locus Specific Mutation Databases (LSDB): FUT2
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUT2
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT2

    Disorders / Diseases
    for FUT2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    FUT2 for disorders           About GeneDecksing

    OMIM gene information: 182100   
    OMIM disorders: 612542  
    20/39 diseases for FUT2 (see all 39):    About MalaCards
    norwalk virus infection, resistance to    bombay phenotype    paralytic squint    spontaneous ocular nystagmus
    aortic valve insufficiency    vestibular nystagmus    pernicious anemia    atrophic gastritis
    spontaneous abortion    nystagmus    toxic shock syndrome    cystic fibrosis lung disease
    cystic fibrosis    staphyloenterotoxemia    gastritis    mastitis
    gastroenteritis    hemorrhagic disease    colon cancer    fibrosis

    3 diseases from the University of Copenhagen DISEASES database for FUT2:
    Staphyloenterotoxemia     Toxic shock syndrome     Mastitis

    5 Novoseek disease relationships for FUT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 9.72 2 12692541 (1), 19522218 (1)
    necrosis 0 1 14727687 (1)
    colon cancer 0 2 9219535 (1), 12652076 (1)
    tumors 0 4 9219535 (1), 14727687 (1), 11501068 (1)
    cancer 0 4 9219535 (1), 8663168 (1), 9458099 (1)

    Genetic Association Database (GAD): FUT2
    Human Genome Epidemiology (HuGE) Navigator: FUT2 (37 documents)

    Export disorders for FUT2 gene to outside databases

    Publications
    for FUT2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT2 gene, integrated from 9 sources (see all 164):
    (articles sorted by number of sources associating them with FUT2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Polymorphism and distribution of the Secretor alpha(1,2)-fucosyltransferase gene in various Taiwanese populations. (PubMed id 11606829)1, 4, 9 Yu L.C....Lin M. (2001)
    2. Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2). (PubMed id 9219535)1, 2, 9 Koda Y.... Kimura H. (1997)
    3. Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals. (PubMed id 8621666)1, 2, 9 Kudo T....Narimatsu H. (1996)
    4. The fusion allele of the FUT2 (secretor type alpha(1,2)-fucosyltransferase) gene at a high frequency and a new se385 allele in a Korean population. (PubMed id 15809881)1, 4, 9 Park K.U....Kim J.Q. (2005)
    5. Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa. (PubMed id 9760207)1, 2, 9 Liu Y....Kimura H. (1998)
    6. The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9. (PubMed id 1763885)1, 3, 9 Ball S.P....Oriol R. (1991)
    7. Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. (PubMed id 7876235)1, 2, 9 Kelly R.J.... Lowe J.B. (1995)
    8. Molecular analysis of mutations and polymorphisms of the Lewis secretor type alpha(1,2)-fucosyltransferase gene reveals that Taiwan aborigines are of Austronesian derivation. (PubMed id 11916003)1, 4, 9 Chang J.G....Peng C.T. (2002)
    9. [Study of ABO blood group secretor type alpha(1,2)-fucosyltransferase gene polymorphism in Chinese] (PubMed id 12645255)1, 4, 9 Zhang Y....Jin F. (2002)
    10. Polymorphisms of two fucosyltransferase genes (Lewis and Secretor genes) involving type I Lewis antigens are associated with the presence of anti-Helicobacter pylori IgG antibody. (PubMed id 11535550)1, 4, 9 Ikehara Y....Tatematsu M. (2001)

    External Searches for FUT2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FUT2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2524 HGNC: 4013 AceView: FUT2 Ensembl:ENSG00000176920 euGenes: HUgn2524
    ECgene: FUT2 Kegg: 2524 H-InvDB: FUT2

    Other Databases showing FUT2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing FUT2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT2 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=hh
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT2
    SeattleSNPshttp://pga.gs.washington.edu/data/fut2/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_599

    Intellectual Property
    for FUT2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for FUT2 gene:
    Search GeneIP for patents involving FUT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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