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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT2 Gene

protein-coding   GIFtS: 61
GCID: GC19P049199

Fucosyltransferase 2 (Secretor Status Included)


(Previous symbol: SE)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Fucosyltransferase 2 (Secretor Status Included)1 2     2)FT21
GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 21 2 3     Alpha (11
Secretor Blood Group Alpha-2-Fucosyltransferase1 2 3     alpha(11
Secretor Factor1 2 3     Se22
SE1 2 5     Alpha (1,2) Fucosyltransferase2
Galactoside 2-Alpha-L-Fucosyltransferase 21 2     alpha(1,2)FT22
Alpha(1,2)FT 22 3     sej2
SEC22 3     SE23
EC 2.4.1.693 8     Se3
B12QTL12 5     Fucosyltransferase 23
2) Fucosyltransferase1     

External Ids:    HGNC: 40131   Entrez Gene: 25242   Ensembl: ENSG000001769207   OMIM: 1821005   UniProtKB: Q109813   

Export aliases for FUT2 gene to outside databases

Previous GC identifers: GC19P049896 GC19P049551 GC19P053859 GC19P053875 GC19P053869 GC19P045578


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FUT2 Gene:
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor
of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This
gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the
same protein have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for FUT2 Gene: 
FUT2 (fucosyltransferase 2 (secretor status included)) is a protein-coding gene. Diseases associated with FUT2 include aortic valve insufficiency, and paralytic squint, and among its related super-pathways are Metabolism. GO annotations related to this gene include galactoside 2-alpha-L-fucosyltransferase activity and fucosyltransferase activity. An important paralog of this gene is FUT1.

UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
Function: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an
essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes
fucosylate the same acceptor substrates but exhibit different Km values

Gene Wiki entry for FUT2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT2 gene promoter:
         AhR   Elk-1   Tal-1   p53   LCR-F1   E47   SRY   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUT2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

FUT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049199:  view genomic region     (about GC identifiers)

Start:
49,199,228 bp from pter      End:
49,209,207 bp from pter
Size:
9,980 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981 (See protein sequence)
Recommended Name: Galactoside 2-alpha-L-fucosyltransferase 2  
Size: 343 amino acids; 39017 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
Note=Membrane-bound form in trans cisternae of Golgi
Miscellaneous: There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are
expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin
respectively
Sequence caution: Sequence=BAA11638.1; Type=Erroneous initiation;
Secondary accessions: Q0VAG5 Q14338 Q5D0G2
Alternative initiation: 2 isoforms:  Q10981-1   Q10981-2   

Explore the universe of human proteins at neXtProt for FUT2: NX_Q10981

Explore proteomics data for FUT2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q10981

  • 4/23 DME Specific Peptides for FUT2 (Q10981) (see all 23)
     GMWTINA  EFTLHDH  LAPIFRI  AAFLPEW 

    FUT2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FUT2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_000502.4  NP_001091107.1  

    ENSEMBL proteins: 
     ENSP00000430227   ENSP00000387498   ENSP00000375748  

    Human Recombinant Protein Products for FUT2: 
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    Novus Biologicals FUT2 Proteins
    Novus Biologicals FUT2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FUT2 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS11698403
    GO:0016020membrane ----
    GO:0030173integral to Golgi membrane NAS--
    GO:0032580Golgi cisterna membrane IEA--

    FUT2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    FUT: Fucosyltransferases

    1 InterPro protein domain:
     IPR002516 Glyco_trans_11

    Graphical View of Domain Structure for InterPro Entry Q10981

    ProtoNet protein and cluster: Q10981

    1 Blocks protein domain: IPB002516 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Similarity: Belongs to the glycosyltransferase 11 family


    FUT2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT2_HUMAN, Q10981
    Function: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an
    essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes
    fucosylate the same acceptor substrates but exhibit different Km values
    Catalytic activity: GDP-beta-L-fucose +
    beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
    = GDP +
    alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

         Genatlas biochemistry entry for FUT2:
    fucosyltransferase,alpha-(1,2),2,type I (secretor status)

         Enzyme Number (IUBMB): EC 2.4.1.691 2

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008107galactoside 2-alpha-L-fucosyltransferase activity TAS11698403
    GO:0008417fucosyltransferase activity TAS7876235
         
    FUT2 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fut2):
     digestive/alimentary  immune system  reproductive system 

    FUT2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FUT2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FUT2 
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FUT2:
    hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidFUT2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Sino Biological Human cDNA Clone for FUT2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUT2
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for FUT2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.40
    2Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series
    3Glycosphingolipid biosynthesis - globo series
    Glycosphingolipid biosynthesis - globo series

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    3         Kegg Pathways  (Kegg details for FUT2):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - globo series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Pathway: Protein modification; protein glycosylation


    FUT2 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/23 Interacting proteins for FUT2 (ENSP000003757484) via UniProtKB, MINT, STRING, and/or I2D (see all 23)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT1ENSP000003037404STRING: ENSP00000303740
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    B3GNT2ENSP000003055954STRING: ENSP00000305595
    B3GNT4ENSP000003196364STRING: ENSP00000319636
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS7876235
    GO:0006486protein glycosylation TAS11698403
    GO:0036065fucosylation TAS7876235
    GO:0042355L-fucose catabolic process NAS11698403

    FUT2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    FUT2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT2

    2 HMDB Compounds for FUT2    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    2 Novoseek inferred chemical compound relationships for FUT2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    carbohydrates 27.4 6 18271619 (3), 10669366 (1), 18357756 (1), 19522218 (1)
    galactose 17.8 1 9287311 (1)

    Search CenterWatch for drugs/clinical trials and news about FUT2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FUT2 gene (2 alternative transcripts): 
    NM_000511.5  NM_001097638.2  

    Unigene Cluster for FUT2:

    Fucosyltransferase 2 (secretor status included)
    Hs.579928  [show with all ESTs]
    Unigene Representative Sequence: NM_000511
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000522966 ENST00000425340(uc002pke.4 uc010emc.3) ENST00000522283
    ENST00000391876
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate FUT2:
    hsa-miR-1301
    SwitchGear 3'UTR luciferase reporter plasmidFUT2 3' UTR sequence
    Inhib. RNA
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    OriGene ORF clones in mouse, rat for FUT2
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    GenScript: all cDNA clones in your preferred vector (see all 2): FUT2 (NM_000511)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUT2
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat FUT2
    Sirion Biotech Customized lentivirus for stable overexpression of FUT2 
                         Customized lentivirus expression plasmids for stable overexpression of FUT2 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUT2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUT2

    Additional mRNA sequence: 

    AK290277.1 AY751739.1 BT006657.1 D87942.1 

    6 DOTS entries:

    DT.92417557  DT.92012259  DT.97806164  DT.121503292  DT.121503296  DT.121503299 

    6 AceView cDNA sequences:

    NM_000511 D87946 BC001899 BT006657 D87942 D87947 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for FUT2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:              -               
    SP2:                              


    ECgene alternative splicing isoforms for FUT2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGTTGGGTA
    FUT2 Expression
    About this image


    See FUT2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT2

    SOURCE GeneReport for Unigene cluster: Hs.579928

    UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Tissue specificity: Small intestine, colon and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUT2 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fut21 , 5 fucosyltransferase 21, 5 78.91(n)1
    80.47(a)1
      7 (29.41 cM)5
    143441  NM_018876.31  NP_061364.21 
     456485955 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    59(a)
    1 → many
    GL343329.1(853192-856474)
    African clawed frog
    (Xenopus laevis)
    Amphibia fut12 alpha2-fucosyltransferase 76.85(n)    AJ575933.1 
    worm
    (Caenorhabditis elegans)
    Secernentea B0205.46
    Protein B0205.4
    19(a)
    1 → many
    I(10741369-10744443)


    ENSEMBL Gene Tree for FUT2 (if available)
    TreeFam Gene Tree for FUT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT2 gene
    FUT12  
    4 SIMAP similar genes for FUT2 using alignment to 8 protein entries:     FUT2_HUMAN (see all proteins):
    sej    FUT1    h2    h1

    FUT2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for FUT2
    PGOHUM00000250611


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: FUT2_HUMAN, Q10981
    Polymorphism: Three alleles have been identified in the Japanese population: Se1, Se2, and Sej
    Polymorphism: Common polymorphisms in FUT2 define the vitamin B12 plasma level quantitative trait locus 1
    (B12QTL1) [MIM:612542]. Vitamin B12 found in meat and milk products is necessary for the formation of red blood
    cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions.
    Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and
    neurodegenerative disorders, is often related to poor intestinal B12 absorption rather than direct dietary
    deficiency


    10/375 SNPs in FUT2 are shown (see all 375)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs10477811,2,4
    C,F,Hnon-pathogenic149383192(+) GCCACA/TTCCCG 4 I F mis1 ese313Minor allele frequency- T:0.03MN NA NS EA 5080
    rs6013381,2
    C,F,A,Hpathogenic149383235(+) CTCCTG/AGACCT 4 /* /W stg124Minor allele frequency- A:0.45NS EA NA WA CSA EU 7298
    rs353989181,2
    C,F--45586358(+) GTGAT-/GTGGTGTT 2 -- cds15Minor allele frequency- GTG:0.01MN 404
    rs283628441,2
    C,F--49208345(+) GCTCA-/CTGTTT 2 -- ut312Minor allele frequency- C:0.40NS 94
    rs1128209941,2
    C,F--49208380(+) TTTTTC/TTTTTT 2 -- ut311Minor allele frequency- T:0.50WA 2
    rs1400511241,2
    C--49373813(+) GCTGGA/GATTAC 2 -- us2k10--------
    rs126088541,2
    H--49373841(+) cccagC/Ttaatt 2 -- us2k10--------
    rs1827770911,2
    --49373869(+) ATGGAA/GTTTCA 2 -- us2k10--------
    rs1455781211,2
    C--49373937(+) GCCTCA/GGCCTC 2 -- us2k10--------
    rs1876586191,2
    --49374077(+) TTTTTG/TTTTTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for FUT2 (49199228 - 49209207 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for FUT2 (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676755CNV Deletion23128226
    esv2664951CNV Deletion23128226
    esv2718682CNV Deletion23290073
    nsv458719CNV Loss19166990
    dgv3968n71CNV Loss21882294
    nsv516677CNV Loss19592680
    nsv912239CNV Loss21882294
    nsv912241CNV Loss21882294
    nsv912237CNV Loss21882294
    dgv3966n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): FUT2

    Locus Specific Mutation Databases (LSDB): FUT2
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing FUT2
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 182100   
    OMIM disorders: 612542  
    20/34 diseases for FUT2 (see all 34):    About MalaCards
    aortic valve insufficiency    paralytic squint    spontaneous ocular nystagmus    pernicious anemia
    staphyloenterotoxemia    vestibular nystagmus    atrophic gastritis    hemorrhagic disease
    toxic shock syndrome    mastitis    gastritis    gastroenteritis
    primary sclerosing cholangitis    sclerosing cholangitis    cystic fibrosis    cholangitis
    crohn's disease    choriocarcinoma    colon cancer    thrombosis

    3 diseases from the University of Copenhagen DISEASES database for FUT2:
    Staphyloenterotoxemia     Toxic shock syndrome     Mastitis

    FUT2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    5 Novoseek inferred disease relationships for FUT2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 9.72 2 12692541 (1), 19522218 (1)
    necrosis 0 1 14727687 (1)
    colon cancer 0 2 9219535 (1), 12652076 (1)
    tumors 0 4 9219535 (1), 14727687 (1), 11501068 (1)
    cancer 0 4 9219535 (1), 8663168 (1), 9458099 (1)

    Genetic Association Database (GAD): FUT2
    Human Genome Epidemiology (HuGE) Navigator: FUT2 (37 documents)

    Export disorders for FUT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT2 gene, integrated from 9 sources (see all 173):
    (articles sorted by number of sources associating them with FUT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Common variants of FUT2 are associated with plasma vitamin B12 levels. (PubMed id 18776911)1, 2, 4 Hazra A.... Hunter D.J. (2008)
    2. Polymorphism and distribution of the Secretor alpha(1,2)-fucosyltransferase gene in various Taiwanese populations. (PubMed id 11606829)1, 4, 9 Yu L.C....Lin M. (2001)
    3. Infection-associated FUT2 (Fucosyltransferase 2) gene tic variation and impact on functionality assessed by in vivo studies. (PubMed id 19757028)1, 4, 9 Silva L.M....David L. (2010)
    4. Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2). (PubMed id 9219535)1, 2, 9 Koda Y.... Kimura H. (1997)
    5. Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals. (PubMed id 8621666)1, 2, 9 Kudo T....Narimatsu H. (1996)
    6. The fusion allele of the FUT2 (secretor type alpha(1,2)-fucosyltransferase) gene at a high frequency and a new se385 allele in a Korean population. (PubMed id 15809881)1, 4, 9 Park K.U....Kim J.Q. (2005)
    7. Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa. (PubMed id 9760207)1, 2, 9 Liu Y....Kimura H. (1998)
    8. Genetic variation of FUT2 in Ovambos, Turks, and Mongolians. (PubMed id 18422843)1, 4, 9 Soejima M....Koda Y. (2008)
    9. The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9. (PubMed id 1763885)1, 3, 9 Ball S.P....Oriol R. (1991)
    10. Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. (PubMed id 7876235)1, 2, 9 Kelly R.J.... Lowe J.B. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2524 HGNC: 4013 AceView: FUT2 Ensembl:ENSG00000176920 euGenes: HUgn2524
    ECgene: FUT2 Kegg: 2524 H-InvDB: FUT2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT2 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=hh
    GGDBhttp://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT2
    SeattleSNPshttp://pga.gs.washington.edu/data/fut2/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_599

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FUT2 gene:
    Search GeneIP for patents involving FUT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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