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Aliases for FUT2 Gene

Aliases for FUT2 Gene

  • Fucosyltransferase 2 (Secretor Status Included) 2 3
  • GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 2 2 3 4
  • Secretor Blood Group Alpha-2-Fucosyltransferase 2 3 4
  • Secretor Factor 2 3 4
  • SE 3 4 6
  • Galactoside 2-Alpha-L-Fucosyltransferase 2 2 3
  • Alpha (1,2) Fucosyltransferase 2 3
  • Alpha(1,2)FT 2 3 4
  • Alpha(1,2)FT2 2 3
  • EC 2.4.1.69 4 64
  • B12QTL1 3 6
  • SEC2 3 4
  • Se2 3 4
  • Fucosyltransferase 2 4
  • Sej 3

External Ids for FUT2 Gene

Previous Symbols for FUT2 Gene

  • SE

Summaries for FUT2 Gene

Entrez Gene Summary for FUT2 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT2 Gene

FUT2 (Fucosyltransferase 2 (Secretor Status Included)) is a Protein Coding gene. Diseases associated with FUT2 include staphyloenterotoxemia and atrophic gastritis. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT1.

UniProtKB/Swiss-Prot for FUT2 Gene

  • Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values

Gene Wiki entry for FUT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT2 Gene

Genomics for FUT2 Gene

Genomic Location for FUT2 Gene

Start:
48,695,971 bp from pter
End:
48,705,950 bp from pter
Size:
9,980 bases
Orientation:
Plus strand

Genomic View for FUT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT2 Gene

Regulatory Elements for FUT2 Gene

Proteins for FUT2 Gene

  • Protein details for FUT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10981-FUT2_HUMAN
    Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 2
    Protein Accession:
    Q10981
    Secondary Accessions:
    • Q0VAG5
    • Q14338
    • Q5D0G2

    Protein attributes for FUT2 Gene

    Size:
    343 amino acids
    Molecular mass:
    39017 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively
    SequenceCaution:
    • Sequence=BAA11638.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FUT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUT2 Gene

Proteomics data for FUT2 Gene at MOPED

Post-translational modifications for FUT2 Gene

  • Glycosylation at Asn188, Asn282, and Asn308

Other Protein References for FUT2 Gene

Domains for FUT2 Gene

Gene Families for FUT2 Gene

HGNC:
  • FUT :Fucosyltransferases

Protein Domains for FUT2 Gene

UniProtKB/Swiss-Prot:

FUT2_HUMAN
Family:
  • Belongs to the glycosyltransferase 11 family.:
    • Q10981
genes like me logo Genes that share domains with FUT2: view

Function for FUT2 Gene

Molecular function for FUT2 Gene

GENATLAS Biochemistry: fucosyltransferase,alpha-(1,2),2,type I (secretor status)
UniProtKB/Swiss-Prot CatalyticActivity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
UniProtKB/Swiss-Prot Function: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values

Enzyme Numbers (IUBMB) for FUT2 Gene

Gene Ontology (GO) - Molecular Function for FUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity TAS 11698403
GO:0008417 fucosyltransferase activity TAS 7876235
genes like me logo Genes that share ontologies with FUT2: view
genes like me logo Genes that share phenotypes with FUT2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FUT2 Gene

Localization for FUT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT2 Gene COMPARTMENTS Subcellular localization image for FUT2 gene
Compartment Confidence
golgi apparatus 5
extracellular 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with FUT2: view

Pathways for FUT2 Gene

genes like me logo Genes that share pathways with FUT2: view

UniProtKB/Swiss-Prot Q10981-FUT2_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for FUT2 Gene

Gene Ontology (GO) - Biological Process for FUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 7876235
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation IBA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT2: view

Compounds for FUT2 Gene

(2) HMDB Compounds for FUT2 Gene

Compound Synonyms Cas Number PubMed IDs
GDP-L-fucose
  • GDP-beta-L-fucose
15839-70-0
Guanosine diphosphate
  • 5'-GDP
146-91-8

(2) Novoseek inferred chemical compound relationships for FUT2 Gene

Compound -log(P) Hits PubMed IDs
carbohydrates 27.4 6
galactose 17.8 1
genes like me logo Genes that share compounds with FUT2: view

Transcripts for FUT2 Gene

mRNA/cDNA for FUT2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT2 Gene

Fucosyltransferase 2 (secretor status included):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for FUT2 Gene

GeneLoc Exon Structure for
FUT2
ECgene alternative splicing isoforms for
FUT2

Expression for FUT2 Gene

mRNA expression in normal human tissues for FUT2 Gene

mRNA differential expression in normal tissues according to GTEx for FUT2 Gene

This gene is overexpressed in Minor Salivary Gland (17.9), Esophagus - Mucosa (6.8), and Colon - Transverse (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for FUT2 Gene

SOURCE GeneReport for Unigene cluster for FUT2 Gene Hs.579928

mRNA Expression by UniProt/SwissProt for FUT2 Gene

Q10981-FUT2_HUMAN
Tissue specificity: Small intestine, colon and lung
genes like me logo Genes that share expressions with FUT2: view

Orthologs for FUT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT2 36
  • 99.11 (n)
  • 99.11 (a)
FUT2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUT2 36
  • 85.47 (n)
  • 84.45 (a)
FUT2 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUT2 37
  • 60 (a)
OneToOne
LOC484398 36
  • 87.51 (n)
  • 86.73 (a)
mouse
(Mus musculus)
Mammalia Fut2 36
  • 78.91 (n)
  • 80.47 (a)
Fut2 16
Fut2 37
  • 80 (a)
OneToMany
Sec1 37
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FUT2 37
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUT2 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut2 36
  • 77.45 (n)
  • 80.47 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia fut1 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497569 36
  • 61.27 (n)
  • 59.71 (a)
Species with no ortholog for FUT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT2 Gene

ENSEMBL:
Gene Tree for FUT2 (if available)
TreeFam:
Gene Tree for FUT2 (if available)

Paralogs for FUT2 Gene

Paralogs for FUT2 Gene

Selected SIMAP similar genes for FUT2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for FUT2 Gene

genes like me logo Genes that share paralogs with FUT2: view

Variants for FUT2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT2 Gene

Q10981-FUT2_HUMAN
Common polymorphisms in FUT2 define the vitamin B12 plasma level quantitative trait locus 1 (B12QTL1) [MIM:612542]. Vitamin B12 found in meat and milk products is necessary for the formation of red blood cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodegenerative disorders, is often related to poor intestinal B12 absorption rather than direct dietary deficiency

Sequence variations from dbSNP and Humsavar for FUT2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs281376 -- 48,704,181(+) ctttg(G/T)gaggc utr-variant-3-prime
rs281377 -- 48,703,346(+) CTGAA(C/T)GACTG reference, synonymous-codon
rs368565 -- 48,697,960(+) AAGTG(C/T)TGGGA intron-variant
rs418821 -- 48,696,547(+) CTGCC(C/G)TCGCC intron-variant
rs480133 -- 48,695,750(+) GACCC(C/T)CGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for FUT2 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294
nsv912235 CNV Loss 21882294
nsv912236 CNV Gain 21882294
nsv912237 CNV Loss 21882294
esv2664951 CNV Deletion 23128226
nsv458719 CNV Loss 19166990
nsv912238 CNV Gain 21882294
nsv442468 CNV CNV 18776908
nsv912239 CNV Loss 21882294
dgv3968n71 CNV Loss 21882294
nsv912241 CNV Loss 21882294
esv2718682 CNV Deletion 23290073
esv2676755 CNV Deletion 23128226
nsv516677 CNV Loss 19592680

Relevant External Links for FUT2 Gene

HapMap Linkage Disequilibrium report
FUT2
Human Gene Mutation Database (HGMD)
FUT2
Locus Specific Mutation Databases (LSDB)
FUT2
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for FUT2 Gene

(1) OMIM Diseases for FUT2 Gene (182100)

(3) University of Copenhagen DISEASES for FUT2 Gene

(5) Novoseek inferred disease relationships for FUT2 Gene

Disease -log(P) Hits PubMed IDs
virus infection 9.72 2
necrosis 0 1
colon cancer 0 2
tumors 0 3
cancer 0 3

Relevant External Links for FUT2

Genetic Association Database (GAD)
FUT2
Human Genome Epidemiology (HuGE) Navigator
FUT2
genes like me logo Genes that share disorders with FUT2: view

No data available for UniProtKB/Swiss-Prot for FUT2 Gene

Publications for FUT2 Gene

  1. The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9. (PMID: 1763885) Ball S.P. … Oriol R. (Ann. Hum. Genet. 1991) 2 3 23
  2. Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. (PMID: 7876235) Kelly R.J. … Lowe J.B. (J. Biol. Chem. 1995) 3 4 23
  3. Molecular genetic analysis of the human Lewis histo-blood group system. II. Secretor gene inactivation by a novel single missense mutation A385T in Japanese nonsecretor individuals. (PMID: 8621666) Kudo T. … Narimatsu H. (J. Biol. Chem. 1996) 3 4 23
  4. Extensive polymorphism of the FUT2 gene in an African (Xhosa) population of South Africa. (PMID: 9760207) Liu Y. … Kimura H. (Hum. Genet. 1998) 3 4 23
  5. Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2). (PMID: 9219535) Koda Y. … Kimura H. (Eur. J. Biochem. 1997) 3 4 23

Products for FUT2 Gene

Sources for FUT2 Gene

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