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Aliases for FUT2 Gene

Aliases for FUT2 Gene

  • Fucosyltransferase 2 2 3 4 5
  • GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 2 2 3 4
  • Secretor Blood Group Alpha-2-Fucosyltransferase 2 3 4
  • Secretor Factor 2 3 4
  • Fucosyltransferase 2 (Secretor Status Included) 2 3
  • Alpha (1,2) Fucosyltransferase 2 3
  • Alpha(1,2)FT 2 3 4
  • Alpha(1,2)FT2 2 3
  • EC 2.4.1.69 4 63
  • SEC2 3 4
  • Se2 3 4
  • SE 3 4
  • Galactoside 2-Alpha-L-Fucosyltransferase 2 2
  • B12QTL1 3
  • Sej 3

External Ids for FUT2 Gene

Previous HGNC Symbols for FUT2 Gene

  • SE

Previous GeneCards Identifiers for FUT2 Gene

  • GC19P049896
  • GC19P049551
  • GC19P053859
  • GC19P053875
  • GC19P053869
  • GC19P049199
  • GC19P045578

Summaries for FUT2 Gene

Entrez Gene Summary for FUT2 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT2 Gene

FUT2 (Fucosyltransferase 2) is a Protein Coding gene. Diseases associated with FUT2 include Plasmacytic Leukemia and Staphyloenterotoxemia. Among its related pathways are Glycosphingolipid biosynthesis - globo series and Glycosphingolipid biosynthesis - lacto and neolacto series. GO annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT1.

UniProtKB/Swiss-Prot for FUT2 Gene

  • Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.

Gene Wiki entry for FUT2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT2 Gene

Genomics for FUT2 Gene

Regulatory Elements for FUT2 Gene

Enhancers for FUT2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FUT2 on UCSC Golden Path with GeneCards custom track

Promoters for FUT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUT2 Gene

Chromosome:
19
Start:
48,695,971 bp from pter
End:
48,705,950 bp from pter
Size:
9,980 bases
Orientation:
Plus strand

Genomic View for FUT2 Gene

Genes around FUT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT2 Gene

Proteins for FUT2 Gene

  • Protein details for FUT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10981-FUT2_HUMAN
    Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 2
    Protein Accession:
    Q10981
    Secondary Accessions:
    • Q0VAG5
    • Q14338
    • Q5D0G2

    Protein attributes for FUT2 Gene

    Size:
    343 amino acids
    Molecular mass:
    39017 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.
    SequenceCaution:
    • Sequence=BAA11638.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FUT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUT2 Gene

Proteomics data for FUT2 Gene at MOPED

Post-translational modifications for FUT2 Gene

  • Glycosylation at Asn 188, Asn 282, and Asn 308
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT2 Gene

Domains & Families for FUT2 Gene

Gene Families for FUT2 Gene

Protein Domains for FUT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q10981

UniProtKB/Swiss-Prot:

FUT2_HUMAN :
  • Belongs to the glycosyltransferase 11 family.
Family:
  • Belongs to the glycosyltransferase 11 family.
genes like me logo Genes that share domains with FUT2: view

Function for FUT2 Gene

Molecular function for FUT2 Gene

GENATLAS Biochemistry:
fucosyltransferase,alpha-(1,2),2,type I (secretor status)
UniProtKB/Swiss-Prot CatalyticActivity:
GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
UniProtKB/Swiss-Prot Function:
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.

Enzyme Numbers (IUBMB) for FUT2 Gene

genes like me logo Genes that share phenotypes with FUT2: view

Animal Models for FUT2 Gene

MGI Knock Outs for FUT2:

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUT2 Gene

Localization for FUT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT2 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT2 Gene COMPARTMENTS Subcellular localization image for FUT2 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 2
endoplasmic reticulum 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT2: view

Pathways & Interactions for FUT2 Gene

genes like me logo Genes that share pathways with FUT2: view

UniProtKB/Swiss-Prot Q10981-FUT2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT2 Gene

Gene Ontology (GO) - Biological Process for FUT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA,TAS 7876235
genes like me logo Genes that share ontologies with FUT2: view

No data available for SIGNOR curated interactions for FUT2 Gene

Drugs & Compounds for FUT2 Gene

(1) Drugs for FUT2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0

(3) Additional Compounds for FUT2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
GDP-L-fucose
  • (6-deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
genes like me logo Genes that share compounds with FUT2: view

Transcripts for FUT2 Gene

mRNA/cDNA for FUT2 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUT2 Gene

Fucosyltransferase 2 (secretor status included):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b
SP1: -
SP2:

Relevant External Links for FUT2 Gene

GeneLoc Exon Structure for
FUT2
ECgene alternative splicing isoforms for
FUT2

Expression for FUT2 Gene

mRNA expression in normal human tissues for FUT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUT2 Gene

This gene is overexpressed in Minor Salivary Gland (x17.9), Esophagus - Mucosa (x6.8), and Colon - Transverse (x5.6).

Protein differential expression in normal tissues from HIPED for FUT2 Gene

This gene is overexpressed in Kidney (33.5), Stomach (23.0), and Oral epithelium (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FUT2 Gene



SOURCE GeneReport for Unigene cluster for FUT2 Gene Hs.579928

mRNA Expression by UniProt/SwissProt for FUT2 Gene

Q10981-FUT2_HUMAN
Tissue specificity: Small intestine, colon and lung.
genes like me logo Genes that share expression patterns with FUT2: view

Primer Products

No data available for Protein tissue co-expression partners for FUT2 Gene

Orthologs for FUT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FUT2 35
  • 85.47 (n)
  • 84.45 (a)
FUT2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC484398 35
  • 87.51 (n)
  • 86.73 (a)
FUT2 36
  • 60 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fut2 35
  • 78.91 (n)
  • 80.47 (a)
Fut2 16
Fut2 36
  • 80 (a)
OneToMany
Sec1 36
  • 61 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia FUT2 35
  • 99.11 (n)
  • 99.11 (a)
FUT2 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut2 35
  • 77.45 (n)
  • 80.47 (a)
oppossum
(Monodelphis domestica)
Mammalia FUT2 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUT2 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100497569 35
  • 61.27 (n)
  • 59.71 (a)
African clawed frog
(Xenopus laevis)
Amphibia fut1 35
Species with no ortholog for FUT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT2 Gene

ENSEMBL:
Gene Tree for FUT2 (if available)
TreeFam:
Gene Tree for FUT2 (if available)

Paralogs for FUT2 Gene

Paralogs for FUT2 Gene

(4) SIMAP similar genes for FUT2 Gene using alignment to 8 proteins:

Pseudogenes.org Pseudogenes for FUT2 Gene

genes like me logo Genes that share paralogs with FUT2: view

Variants for FUT2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT2 Gene

FUT2_HUMAN-Q10981
Common polymorphisms in FUT2 define the vitamin B12 plasma level quantitative trait locus 1 (B12QTL1) [MIM:612542]. Vitamin B12 found in meat and milk products is necessary for the formation of red blood cells, DNA synthesis during cell division, and maintenance of the myelin nerve sheath, among other functions. Deficiency in vitamin B12, clinically associated with pernicious anemia, cardiovascular disease, cancer, and neurodegenerative disorders, is often related to poor intestinal B12 absorption rather than direct dietary deficiency.
FUT2_HUMAN-Q10981
Three alleles have been identified in the Japanese population: Se1, Se2, and Sej.

Sequence variations from dbSNP and Humsavar for FUT2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_003422 -
VAR_003423 -
VAR_003424 -
VAR_003425 -
VAR_022187 -

Structural Variations from Database of Genomic Variants (DGV) for FUT2 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294
nsv912235 CNV Loss 21882294
nsv912236 CNV Gain 21882294
nsv912237 CNV Loss 21882294
esv2664951 CNV Deletion 23128226
nsv458719 CNV Loss 19166990
nsv912238 CNV Gain 21882294
nsv442468 CNV CNV 18776908
nsv912239 CNV Loss 21882294
dgv3968n71 CNV Loss 21882294
nsv912241 CNV Loss 21882294
esv2718682 CNV Deletion 23290073
esv2676755 CNV Deletion 23128226
nsv516677 CNV Loss 19592680

Variation tolerance for FUT2 Gene

Residual Variation Intolerance Score: 99% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.88; 99.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT2 Gene

Human Gene Mutation Database (HGMD)
FUT2
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group System

Disorders for FUT2 Gene

MalaCards: The human disease database

(16) MalaCards diseases for FUT2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
plasmacytic leukemia
  • leukemia, plasma cell
staphyloenterotoxemia
  • staphylococcal food poisoning
pernicious anemia
  • addison's anaemia
sclerosing cholangitis
  • fibrosing cholangitis
spontaneous ocular nystagmus
  • ocular nystagmus
- elite association - COSMIC cancer census association via MalaCards
Search FUT2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUT2

Genetic Association Database (GAD)
FUT2
Human Genome Epidemiology (HuGE) Navigator
FUT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT2
genes like me logo Genes that share disorders with FUT2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUT2 Gene

Publications for FUT2 Gene

  1. Common variants of FUT2 are associated with plasma vitamin B12 levels. (PMID: 18776911) Hazra A. … Hunter D.J. (Nat. Genet. 2008) 3 4 48 67
  2. The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9. (PMID: 1763885) Ball S.P. … Oriol R. (Ann. Hum. Genet. 1991) 2 3 23
  3. Infection-associated FUT2 (Fucosyltransferase 2) genetic variation and impact on functionality assessed by in vivo studies. (PMID: 19757028) Silva L.M. … David L. (Glycoconj. J. 2010) 3 23
  4. Widespread balancing selection and pathogen-driven selection at blood group antigen genes. (PMID: 18997004) Fumagalli M. … Sironi M. (Genome Res. 2009) 3 23
  5. The G428A nonsense mutation in FUT2 provides strong but not absolute protection against symptomatic GII.4 Norovirus infection. (PMID: 19440360) Carlsson B. … Svensson L. (PLoS ONE 2009) 3 23

Products for FUT2 Gene

Sources for FUT2 Gene

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