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Aliases for FUT11 Gene

Aliases for FUT11 Gene

  • Fucosyltransferase 11 2 3 4 5
  • Galactoside 3-L-Fucosyltransferase 11 3 4
  • Alpha (1,3) Fucosyltransferase 2 3
  • Fucosyltransferase XI 3 4
  • Fuc-TXI 3 4
  • FucT-XI 3 4
  • Fucosyltransferase 11 (Alpha (1,3) Fucosyltransferase) 2
  • Alpha-(1,3)-Fucosyltransferase 11 3
  • EC 2.4.1.- 4
  • EC 2.4.1 58

External Ids for FUT11 Gene

Previous GeneCards Identifiers for FUT11 Gene

  • GC10P074876
  • GC10P074849
  • GC10P075202
  • GC10P075532
  • GC10P069528

Summaries for FUT11 Gene

GeneCards Summary for FUT11 Gene

FUT11 (Fucosyltransferase 11) is a Protein Coding gene. GO annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT10.

UniProtKB/Swiss-Prot for FUT11 Gene

  • Probable fucosyltransferase.

Additional gene information for FUT11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT11 Gene

Genomics for FUT11 Gene

Regulatory Elements for FUT11 Gene

Enhancers for FUT11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H073809 1.3 ENCODE dbSUPER 29.9 +38.8 38843 3 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF766 ZNF143 ZNF207 SP3 SP5 ECD ZSWIM8 DUSP8P5 NDST2 SEC24C FUT11 ENSG00000272140 GLUD1P3 ENSG00000242288 CAMK2G
GH10H073741 1.1 ENCODE 30 -28.6 -28570 4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ECD AGAP5 FUT11 GLUD1P3 DUSP8P5 ENSG00000272140 AP3M1 ENSG00000224195 VCL SEC24C
GH10H073646 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -120.1 -120111 11 HDGF PKNOX1 FOXA2 ARNT ARID4B ETS1 TCF12 GATA2 FOS ATF7 MYOZ1 ZSWIM8 NDST2 SEC24C ZSWIM8-AS1 FUT11 ECD ENSG00000272140 AP3M1 GLUD1P3
GH10H073815 1.4 Ensembl ENCODE dbSUPER 17.6 +44.6 44609 2 HDAC1 PKNOX1 ATF1 TCF12 GATA2 ATF7 ETV6 CREM SMARCA5 CEBPB FUT11 MYOZ1 NDST2 ENSG00000224195 ENSG00000229990
GH10H073886 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12 +118.8 118835 10 HDGF PKNOX1 FOXA2 SIN3A ZNF2 ZNF121 GLIS2 GATA2 ZNF143 ZNF207 NDST2 ENSG00000272791 ENSG00000268584 AGAP5 ENSG00000227540 C10orf55 FUT11 ENSG00000229990 ENSG00000272599 ENSG00000224195
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FUT11 on UCSC Golden Path with GeneCards custom track

Promoters for FUT11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000029858 1125 2601 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 ZNF766

Genomic Location for FUT11 Gene

Chromosome:
10
Start:
73,772,175 bp from pter
End:
73,780,251 bp from pter
Size:
8,077 bases
Orientation:
Plus strand

Genomic View for FUT11 Gene

Genes around FUT11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT11 Gene

Proteins for FUT11 Gene

  • Protein details for FUT11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495W5-FUT11_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 11
    Protein Accession:
    Q495W5
    Secondary Accessions:
    • Q495W7
    • Q8IYE4

    Protein attributes for FUT11 Gene

    Size:
    492 amino acids
    Molecular mass:
    55816 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FUT11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUT11 Gene

Selected DME Specific Peptides for FUT11 Gene

Q495W5:
  • TEKLWRP
  • QSHCDVP
  • VRDWMPNN
  • WALLHEESP
  • VPVYRGS
  • RYKFHLA
  • TATTEDPE
  • LLSHGPGIRLFN
  • LFPHFPGD
  • PNYLNGFEC
  • MWLQDYWQ
  • REWGVND
  • DSYGKCL
  • LFYGTDF

Post-translational modifications for FUT11 Gene

  • Ubiquitination at isoforms=2242
  • Glycosylation at posLast=5959, posLast=166166, isoforms=2318, and posLast=443443
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT11 Gene

Domains & Families for FUT11 Gene

Gene Families for FUT11 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for FUT11 Gene

Suggested Antigen Peptide Sequences for FUT11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495W5

UniProtKB/Swiss-Prot:

FUT11_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT11: view

Function for FUT11 Gene

Molecular function for FUT11 Gene

UniProtKB/Swiss-Prot Function:
Probable fucosyltransferase.

Enzyme Numbers (IUBMB) for FUT11 Gene

Phenotypes From GWAS Catalog for FUT11 Gene

Gene Ontology (GO) - Molecular Function for FUT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008417 fucosyltransferase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
GO:0046920 alpha-(1->3)-fucosyltransferase activity IBA --
genes like me logo Genes that share ontologies with FUT11: view
genes like me logo Genes that share phenotypes with FUT11: view

Animal Model Products

CRISPR Products

miRNA for FUT11 Gene

miRTarBase miRNAs that target FUT11

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FUT11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUT11 Gene

Localization for FUT11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT11 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUT11 gene
Compartment Confidence
extracellular 5
golgi apparatus 5
nucleus 2
endoplasmic reticulum 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nuclear membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005794 Golgi apparatus IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT11: view

Pathways & Interactions for FUT11 Gene

SuperPathways for FUT11 Gene

No Data Available

UniProtKB/Swiss-Prot Q495W5-FUT11_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for FUT11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006486 protein glycosylation IEA --
GO:0036065 fucosylation IEA --
genes like me logo Genes that share ontologies with FUT11: view

No data available for Pathways by source and SIGNOR curated interactions for FUT11 Gene

Drugs & Compounds for FUT11 Gene

No Compound Related Data Available

Transcripts for FUT11 Gene

Unigene Clusters for FUT11 Gene

Fucosyltransferase 11 (alpha (1,3) fucosyltransferase):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for FUT11
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FUT11 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2:
SP3:

Relevant External Links for FUT11 Gene

GeneLoc Exon Structure for
FUT11
ECgene alternative splicing isoforms for
FUT11

Expression for FUT11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUT11 Gene

Protein differential expression in normal tissues from HIPED for FUT11 Gene

This gene is overexpressed in Heart (40.3) and Testis (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUT11 Gene



Protein tissue co-expression partners for FUT11 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUT11 Gene:

FUT11

SOURCE GeneReport for Unigene cluster for FUT11 Gene:

Hs.588854

Evidence on tissue expression from TISSUES for FUT11 Gene

  • Liver(4.4)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FUT11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUT11 Gene

Orthologs for FUT11 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT11 33 34
  • 98.92 (n)
cow
(Bos Taurus)
Mammalia FUT11 33 34
  • 89.15 (n)
dog
(Canis familiaris)
Mammalia FUT11 33 34
  • 88.32 (n)
mouse
(Mus musculus)
Mammalia Fut11 33 16 34
  • 85.47 (n)
rat
(Rattus norvegicus)
Mammalia Fut11 33
  • 85.42 (n)
oppossum
(Monodelphis domestica)
Mammalia FUT11 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUT11 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUT11 33 34
  • 70.58 (n)
lizard
(Anolis carolinensis)
Reptilia FUT11 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fut11 33
  • 63.05 (n)
Str.7023 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6896 33
zebrafish
(Danio rerio)
Actinopterygii fut11 33 34
  • 60.63 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14032 33
fruit fly
(Drosophila melanogaster)
Insecta FucTC 34
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4390 34
  • 42 (a)
OneToOne
Species where no ortholog for FUT11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUT11 Gene

ENSEMBL:
Gene Tree for FUT11 (if available)
TreeFam:
Gene Tree for FUT11 (if available)

Paralogs for FUT11 Gene

Paralogs for FUT11 Gene

(1) SIMAP similar genes for FUT11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUT11: view

Variants for FUT11 Gene

Sequence variations from dbSNP and Humsavar for FUT11 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000258573 -- 73,774,573(+) CACAT(A/G)CCTGT intron-variant
rs1000289824 -- 73,774,316(+) TTTTT(A/C/T)AAGCG intron-variant
rs1000368976 -- 73,779,647(+) GCTTG(C/T)AATCT nc-transcript-variant
rs1000569711 -- 73,774,789(+) ACTGG(A/G)AAACA intron-variant
rs1001110001 -- 73,779,906(+) CAGAC(C/T)TTCTC nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FUT11 Gene

Variant ID Type Subtype PubMed ID
nsv1035634 CNV gain 25217958
nsv551516 CNV loss 21841781
nsv825468 CNV gain 20364138
nsv831912 CNV gain 17160897

Variation tolerance for FUT11 Gene

Residual Variation Intolerance Score: 32.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUT11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUT11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUT11 Gene

Disorders for FUT11 Gene

Relevant External Links for FUT11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT11

No disorders were found for FUT11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUT11 Gene

Publications for FUT11 Gene

  1. FUT11 as a potential biomarker of clear cell renal cell carcinoma progression based on meta-analysis of gene expression data. (PMID: 24318988) Zodro E … Wesoly J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2014) 2 3 60
  2. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. (PMID: 11698403) Roos C … Renkonen R (The Journal of biological chemistry 2002) 2 3 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for FUT11 Gene

Sources for FUT11 Gene

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