FUT11 Gene
protein-coding GIFtS: 44
GCID: GC10P075532
|
|
fucosyltransferase 11 (alpha (1,3) fucosyltransferase)
| |
Aliases
for FUT11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fucosyltransferase 11 (Alpha (1,3) Fucosyltransferase)1 2 | | FucT-XI3 | | Fucosyltransferase XI2 3 | | EC 2.4.1.-3 | | Galactoside 3-L-Fucosyltransferase 112 3 | | Fuc-TXI3 | | MGC332021 | | FucT-XI3 | | Alpha-(1,3)-Fucosyltransferase 112 | | Fucosyltransferase 113 | | Fuc-TXI3 | | EC 2.4.18 |
Export aliases for FUT11 gene to outside databasesPrevious GC identifers: GC10P074876 GC10P074849 GC10P075202 GC10P069528 |
Summaries
for FUT11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FUT11_HUMAN, Q495W5Function: Probable fucosyltransferase (By similarity)
|
Genomic Views
for FUT11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_030059.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FUT11 gene promoter:
Pax-5 p53 GATA-3 Tal-1beta NF-kappaB C/EBPalpha GATA-1 GATA-2 Pax-3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FUT11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q22.2 Ensembl cytogenetic band: 10q22.2 HGNC cytogenetic band: 10q22.3FUT11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10P075532: view genomic region
(about GC identifiers)
Start:
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75,532,049 bp from pter |
End:
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75,538,821 bp from pter |
Size:
|
6,773 bases |
Orientation:
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plus strand |
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Proteins
for FUT11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FUT11_HUMAN, Q495W5 (See
protein sequence)Recommended Name: Alpha-(1,3)-fucosyltransferase 11 Size: 492 amino acids; 55816 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein (By similarity)
Secondary accessions: Q495W7 Q8IYE4Alternative splicing: 2 isoforms: Q495W5-1 Q495W5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FUT11: NX_Q495W5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q495W5
4/14 DME Specific Peptides for FUT11 (Q495W5) (see all 14)
FUT11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_775811.2
ENSEMBL proteins: ENSP00000361932 ENSP00000378270
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- | | GO:0032580 | Golgi cisterna membrane |
IEA | -- |
FUT11 for ontologies About GeneDecksing
FUT11 Antibody Products:
Assay Products for FUT11: |
Protein
Domains /
Families
for FUT11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FUT11 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q495W5ProtoNet protein and cluster: Q495W5 1 Blocks protein family: IPB001503 Glycosyl transferase
UniProtKB/Swiss-Prot: FUT11_HUMAN, Q495W5Similarity: Belongs to the glycosyltransferase 10 family |
Function
for FUT11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FUT11_HUMAN, Q495W5Function: Probable fucosyltransferase (By similarity)Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUT11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUT11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: FUT11 (NM_173540) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUT11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT11 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0046920 | alpha-(1->3)-fucosyltransferase activity |
IEA | -- |
FUT11 for ontologies About GeneDecksing
|
Pathways & Interactions
for FUT11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: FUT11_HUMAN, Q495W5Pathway: Protein modification; protein glycosylationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT11
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006486 | protein glycosylation |
IEA | -- |
FUT11 for ontologies About GeneDecksing
|
Drugs & Compounds
for FUT11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FUT11
Search CenterWatch for drugs/clinical trials and news about FUT11
|
Transcripts
for FUT11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FUT11 gene: NM_173540.2 Unigene Cluster for FUT11: Fucosyltransferase 11 (alpha (1,3) fucosyltransferase) Hs.588854 [show with all ESTs]Unigene Representative Sequence: NM_1735405 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000372841(uc001juz.1 uc001jva.3) ENST00000465695(uc001juy.1)
ENST00000489264 ENST00000462704 ENST00000394790
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUT11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUT11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FUT11 (NM_173540) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUT11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT11 |
Additional cDNA sequence: AK314944.1 BC036037.1 BC100994.1 BC100995.1 BC100996.1 BC100997.1 9 DOTS entries: DT.97799630 DT.40190574 DT.75188821 DT.92420366 DT.91673625 DT.100018762 DT.100022016 DT.100755044 DT.121302242 24/292 AceView cDNA sequences (see all 292): AA323579 F31338 CD366442 BU180505 AK098512 CA443438 BU161209 BE898906 BQ710971 BE292860 CB160708 NM_004922 BX332390 BU737345 AK126671 AW449995 AA928412 BC018928 CK000598 CA448456 BP353055 AA463911 AI309532 NM_198597
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for FUT11 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
|---|
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| SP1: | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FUT11
|
Expression
for FUT11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FUT11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTCAAGGA
About this image
See FUT11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FUT11
SOURCE GeneReport for Unigene cluster: Hs.588854
SABiosciences Expression via Pathway-Focused PCR Array including FUT11:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUT11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FUT11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUT11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUT11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT11 |
Orthologs
for FUT11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FUT11 gene from 4/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FUT111 |
fucosyltransferase 11 (alpha (1,3) fucosyltransferase) |
70.51(n)
69.02(a) |
|
395071 NM_204428.1 NP_989759.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FUT116 |
-- |
67(a) |
1 ↔ 1 |
GL343196.1(1275749-1287143) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.68962 |
Xenopus laevis transcribed sequence with weak similarity more |
76.27(n) |
|
BX845573.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
fut111 |
fucosyltransferase 11 (alpha (1,3) fucosyltransferase) |
60.63(n)
58.82(a) |
|
568888 NM_001077174.1 NP_001070642.1 |
ENSEMBL Gene Tree for FUT11 (if available)
TreeFam Gene Tree for FUT11 (if available) |
Paralogs
for FUT11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FUT11 gene
- FUT52 FUT42 FUT72 FUT62 FUT32 FUT102 FUT92
1 SIMAP similar gene for FUT11 using alignment to 1 protein entry: FUT11_HUMAN:FUT10
FUT11 for paralogs About GeneDecksing
|
Genomic Variants
for FUT11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FUT11 (75532049 - 75538821 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FUT11: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUT11 |
|
Disorders
/ Diseases
for FUT11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for FUT11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FUT11 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FUT11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. (PubMed id 11698403)1, 3 Roos C.... Renkonen R. (2002)
- Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). (PubMed id 19088067)1 Mollicone R....Oriol R. (2009)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- IL-6 and IL-8 increase the expression of glycosyltransferases and sulfotransferases involved in the biosynthesis of sialylated and/or sulfated Lewis x epitopes in the human bronchial mucosa. (PubMed id 17944600)9 Groux-Degroote S.... Delannoy P. (2008)
|
External Searches for FUT11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FUT11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FUT11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FUT11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FUT11 | Pharmacogenomics, SNPs, Pathways | | Functional Glycomics Gateway - GTase | http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_608 |
|
| | |
About This Section
| Patent Information for FUT11 gene:
Search GeneIP for patents involving FUT11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FUT11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUT11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUT11 | | | OriGene Protein Over-expression Lysate for FUT11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for FUT11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUT11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUT11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FUT11 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FUT11 | | OriGene Custom Protein Services for FUT11 | | | OriGene Custom Immunoassay Development | | |
| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FUT11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUT11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUT11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUT11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUT11 |
| |
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| |  |  |  |  | | | | |
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 | | | FUT11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT11 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT11 |
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