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Aliases for FUT10 Gene

Aliases for FUT10 Gene

  • Fucosyltransferase 10 2 3 4
  • Fucosyltransferase 10 (Alpha (1,3) Fucosyltransferase) 2 3 5
  • Galactoside 3-L-Fucosyltransferase 10 3 4
  • Alpha (1,3) Fucosyltransferase 2 3
  • Fucosyltransferase X 3 4
  • Fuc-TX 3 4
  • FucT-X 3 4
  • Alpha 1,3-Fucosyl Transferase 3
  • EC 2.4.1.- 4
  • EC 2.4.1 63

External Ids for FUT10 Gene

Previous GeneCards Identifiers for FUT10 Gene

  • GC00U991275
  • GC08M033679
  • GC08M033084
  • GC08M033286
  • GC08M033347
  • GC08M031760
  • GC08M033228
  • GC08M033370

Summaries for FUT10 Gene

GeneCards Summary for FUT10 Gene

FUT10 (Fucosyltransferase 10) is a Protein Coding gene. GO annotations related to this gene include fucosyltransferase activity and alpha-(1->3)-fucosyltransferase activity. An important paralog of this gene is FUT6.

UniProtKB/Swiss-Prot for FUT10 Gene

  • Probable fucosyltransferase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT10 Gene

Genomics for FUT10 Gene

Regulatory Elements for FUT10 Gene

Enhancers for FUT10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FUT10 on UCSC Golden Path with GeneCards custom track

Promoters for FUT10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUT10 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUT10 Gene

Chromosome:
8
Start:
33,308,611 bp from pter
End:
33,473,478 bp from pter
Size:
164,868 bases
Orientation:
Minus strand

Genomic View for FUT10 Gene

Genes around FUT10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUT10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUT10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT10 Gene

Proteins for FUT10 Gene

  • Protein details for FUT10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P4F1-FUT10_HUMAN
    Recommended name:
    Alpha-(1,3)-fucosyltransferase 10
    Protein Accession:
    Q6P4F1
    Secondary Accessions:
    • A8KAC8
    • Q70GG3
    • Q8IVI6
    • Q8IVI7
    • Q8IVJ3
    • Q8TE43
    • Q9BSR3

    Protein attributes for FUT10 Gene

    Size:
    479 amino acids
    Molecular mass:
    56094 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD24023.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for FUT10 Gene

neXtProt entry for FUT10 Gene

Proteomics data for FUT10 Gene at MOPED

Post-translational modifications for FUT10 Gene

  • Glycosylation at Asn 110 and Asn 168
  • Modification sites at PhosphoSitePlus

Other Protein References for FUT10 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for FUT10 Gene

Gene Families for FUT10 Gene

Protein Domains for FUT10 Gene

Suggested Antigen Peptide Sequences for FUT10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6P4F1

UniProtKB/Swiss-Prot:

FUT10_HUMAN :
  • Belongs to the glycosyltransferase 10 family.
Family:
  • Belongs to the glycosyltransferase 10 family.
genes like me logo Genes that share domains with FUT10: view

Function for FUT10 Gene

Molecular function for FUT10 Gene

UniProtKB/Swiss-Prot Function:
Probable fucosyltransferase.

Enzyme Numbers (IUBMB) for FUT10 Gene

genes like me logo Genes that share phenotypes with FUT10: view

Animal Model Products

miRNA for FUT10 Gene

miRTarBase miRNAs that target FUT10

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUT10 Gene

Localization for FUT10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT10 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT10 Gene COMPARTMENTS Subcellular localization image for FUT10 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 3
nucleus 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for FUT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FUT10: view

Pathways & Interactions for FUT10 Gene

SuperPathways for FUT10 Gene

No Data Available

UniProtKB/Swiss-Prot Q6P4F1-FUT10_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Interacting Proteins for FUT10 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000332757%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000332757 for FUT10 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for FUT10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006457 protein folding NAS 11698403
GO:0006605 protein targeting NAS 11698403
GO:0007399 nervous system development NAS 11698403
GO:0009566 fertilization NAS 11698403
GO:0009790 embryo development NAS 11698403
genes like me logo Genes that share ontologies with FUT10: view

No data available for Pathways by source and SIGNOR curated interactions for FUT10 Gene

Drugs & Compounds for FUT10 Gene

No Compound Related Data Available

Transcripts for FUT10 Gene

Unigene Clusters for FUT10 Gene

Fucosyltransferase 10 (alpha (1,3) fucosyltransferase):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT10 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - -
SP7: - - - - - - -
SP8:
SP9: - - - -
SP10:

Relevant External Links for FUT10 Gene

GeneLoc Exon Structure for
FUT10
ECgene alternative splicing isoforms for
FUT10

Expression for FUT10 Gene

mRNA expression in normal human tissues for FUT10 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FUT10 Gene



SOURCE GeneReport for Unigene cluster for FUT10 Gene Hs.458713

genes like me logo Genes that share expression patterns with FUT10: view

Protein tissue co-expression partners for FUT10 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FUT10 Gene

Orthologs for FUT10 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUT10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FUT10 35
  • 84.89 (n)
  • 86.55 (a)
FUT10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUT10 35
  • 88.28 (n)
  • 88.08 (a)
FUT10 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fut10 35
  • 81.49 (n)
  • 82.05 (a)
Fut10 16
Fut10 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut10 35
  • 83.58 (n)
  • 84.65 (a)
oppossum
(Monodelphis domestica)
Mammalia FUT10 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUT10 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FUT10 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUT10 35
  • 69.53 (n)
  • 72.09 (a)
FUT10 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUT10 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fut10 35
  • 65.46 (n)
  • 66.31 (a)
zebrafish
(Danio rerio)
Actinopterygii fut10 35
  • 61.01 (n)
  • 61.23 (a)
fut10 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta FucTB 37
  • 38 (a)
FucTB 35
  • 50.27 (n)
  • 40.43 (a)
FucTB 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 20 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 25 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
CSA.4382 36
  • 19 (a)
ManyToMany
CSA.4383 36
  • 21 (a)
ManyToMany
CSA.4384 36
  • 19 (a)
ManyToMany
CSA.4386 36
  • 21 (a)
ManyToMany
CSA.4387 36
  • 14 (a)
ManyToMany
CSA.4388 36
  • 20 (a)
ManyToMany
CSA.7058 36
  • 22 (a)
ManyToMany
CSA.7837 36
  • 21 (a)
ManyToMany
CSA.7839 36
  • 21 (a)
ManyToMany
ONA8 36
  • 20 (a)
ManyToMany
Species with no ortholog for FUT10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUT10 Gene

ENSEMBL:
Gene Tree for FUT10 (if available)
TreeFam:
Gene Tree for FUT10 (if available)

Paralogs for FUT10 Gene

Paralogs for FUT10 Gene

(1) SIMAP similar genes for FUT10 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUT10: view

Variants for FUT10 Gene

Sequence variations from dbSNP and Humsavar for FUT10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs16880994 - 33,453,417(+) ATTAA(A/G)ATGCG reference, missense
rs16880853 - 33,389,373(+) CCTAT(A/G)AAAGC reference, missense
rs17855838 - 33,389,073(+) CCTGA(C/G)AGCTG reference, missense
rs17855839 - 33,389,063(+) ATTTC(A/C/G/T)GTTCC reference, missense
rs2056176 -- 33,420,482(+) aatgg(G/T)cattc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUT10 Gene

Variant ID Type Subtype PubMed ID
nsv890714 CNV Gain 21882294
nsv465634 CNV Loss 19166990
esv2657939 CNV Deletion 23128226

Variation tolerance for FUT10 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.98; 93.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FUT10 Gene

Disorders for FUT10 Gene

Relevant External Links for FUT10

Genetic Association Database (GAD)
FUT10
Human Genome Epidemiology (HuGE) Navigator
FUT10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUT10

No disorders were found for FUT10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUT10 Gene

Publications for FUT10 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). (PMID: 19088067) Mollicone R. … Oriol R. (J. Biol. Chem. 2009) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. (PMID: 11698403) Roos C. … Renkonen R. (J. Biol. Chem. 2002) 3
  5. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. (PMID: 12370785) Baboval T. … Smith F.I. (Mamm. Genome 2002) 3

Products for FUT10 Gene

Sources for FUT10 Gene

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