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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUT10 Gene

protein-coding   GIFtS: 45
GCID: GC08M033286

fucosyltransferase 10 (alpha (1,3) fucosyltransferase)

  Search for FUT10
in our new
 Human Malady Compendium 
Biological research products
for FUT10
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Fucosyltransferase 10 (Alpha (1,3) Fucosyltransferase)1 2     FucT-X3
Fucosyltransferase X2 3     EC 2.4.1.-3
Galactoside 3-L-Fucosyltransferase 102 3     Fuc-TX3
Alpha 1,3-Fucosyl Transferase2     FucT-X3
Alpha-(1,3)-Fucosyltransferase 102     Fucosyltransferase 103
Fuc-TX3     EC 2.4.18

External Ids:    HGNC: 192341   Entrez Gene: 847502   Ensembl: ENSG000001727287   UniProtKB: Q6P4F13   

Export aliases for FUT10 gene to outside databases

Previous GC identifers: GC00U991275 GC08M033679 GC08M033084 GC08M033347 GC08M031760


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FUT10_HUMAN, Q6P4F1
Function: Probable fucosyltransferase (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_167187.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUT10 gene promoter:
         Elk-1   FOXF2   MEF-2   LCR-F1   YY1   c-Ets-1   MEF-2A   Nkx6-1   HFH-1   FOXO4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUT10 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUT10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUT10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p12   Ensembl cytogenetic band:  8p12   HGNC cytogenetic band: 8p12

FUT10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT10 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M033286:  view genomic region     (about GC identifiers)

Start:
33,228,342 bp from pter      End:
33,330,940 bp from pter
Size:
102,599 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FUT10_HUMAN, Q6P4F1 (See protein sequence)
Recommended Name: Alpha-(1,3)-fucosyltransferase 10  
Size: 479 amino acids; 56094 Da
Subcellular location: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein
Sequence caution: Sequence=CAD24023.1; Type=Erroneous initiation;
Secondary accessions: A8KAC8 Q70GG3 Q8IVI6 Q8IVI7 Q8IVJ3 Q8TE43 Q9BSR3
Alternative splicing: 7 isoforms:  Q6P4F1-1   Q6P4F1-2   Q6P4F1-3   Q6P4F1-4   Q6P4F1-5   Q6P4F1-6   Q6P4F1-7   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FUT10: NX_Q6P4F1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6P4F1

  • 4/13 DME Specific Peptides for FUT10 (Q6P4F1) (see all 13)
     GRLGQCG  LFYGTDF  FSHPRELA  WWSPLTGE 

    FUT10 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_116053.3  
    ENSEMBL proteins: 
     ENSP00000332757   ENSP00000430428   ENSP00000429870   ENSP00000334997  

    Human Recombinant Protein Products: 
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    Novus Biologicals FUT10 Lysate
    Sino Biological Recombinant Protein for FUT10
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for FUT10

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS11698403
    GO:0016021integral to membrane IEA--
    GO:0032580Golgi cisterna membrane IEA--


    FUT10 for ontologies           About GeneDecksing



    FUT10 Antibody Products: 
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    Uscn ELISAs and CLIAs for FUT10


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FUT10 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR001503 Glyco_trans_10
     IPR017176 Alpha-1_3-FUT_met

    Graphical View of Domain Structure for InterPro Entry Q6P4F1

    ProtoNet protein and cluster: Q6P4F1

    1 Blocks protein family: IPB001503 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT10_HUMAN, Q6P4F1
    Similarity: Belongs to the glycosyltransferase 10 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: FUT10_HUMAN, Q6P4F1
    Function: Probable fucosyltransferase (By similarity)

    Enzyme Numbers (IUBMB): EC 2.4.12 EC 2.4.1.-1

    miRNA
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    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FUT10 (see all 14):
    hsa-miR-4317 hsa-miR-3163 hsa-miR-505 hsa-miR-3910 hsa-miR-576-5p hsa-miR-3667-3p hsa-miR-3680 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidFUT10 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUT10 (see all 4)
    OriGene shRNA RFP: FUT10
    OriGene siRNA: FUT10
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUT10

    Gene Editing
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    Clone
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT10

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0046920alpha-(1->3)-fucosyltransferase activity TAS11698403


    FUT10 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for FUT10:
     Decreased viability with pacli 


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: FUT10_HUMAN, Q6P4F1
    Pathway: Protein modification; protein glycosylation

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUT10

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006457protein folding NAS11698403
    GO:0006486protein glycosylation TAS11698403
    GO:0006605protein targeting NAS11698403
    GO:0007399nervous system development NAS11698403
    GO:0009566fertilization NAS11698403


    FUT10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUT10
    Search CenterWatch for drugs/clinical trials and news about FUT10 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FUT10 gene: 
    NM_032664.3  

    Unigene Cluster for FUT10:

    Fucosyltransferase 10 (alpha (1,3) fucosyltransferase)
    Hs.458713  [show with all ESTs]
    Unigene Representative Sequence: BC063462
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000327671(uc003xjc.3 uc003xjd.3 uc003xje.3 uc011lbi.2)
    ENST00000518672 ENST00000519440 ENST00000517942 ENST00000524021 ENST00000517891
    ENST00000520767(uc003xjg.3 uc003xjh.3) ENST00000518076 ENST00000416169(uc003xji.1)
    ENST00000520935 ENST00000520503 ENST00000335589(uc003xjf.3)

    miRNA
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    OriGene 3'-UTR Clone: FUT10
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FUT10
    8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate FUT10 (see all 14):
    hsa-miR-4317 hsa-miR-3163 hsa-miR-505 hsa-miR-3910 hsa-miR-576-5p hsa-miR-3667-3p hsa-miR-3680 hsa-miR-3692
    SwitchGear 3'UTR luciferase reporter plasmidFUT10 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUT10 (see all 4)
    OriGene shRNA RFP: FUT10
    OriGene siRNA: FUT10
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    Clone
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUT10
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUT10

    Additional cDNA sequence: 

    AJ431184.1 AJ512465.1 AJ535838.1 AJ535839.1 AJ582015.1 AK056199.1 AK098505.1 AK292993.1 
    AK297132.1 AK303231.1 BC004884.2 BC063462.1 

    11 DOTS entries:

    DT.99947782  DT.101980683  DT.40129434  DT.100650151  DT.91927387  DT.100650153  DT.120643928  DT.101955220 
    DT.120643966  DT.99962391  DT.65285256 

    24/60 AceView cDNA sequences (see all 60):

    BX119225 BC004884 NM_032664 CB134738 AJ535839 CR596972 AJ582015 AJ512465 
    BM717062 AJ535838 AI140437 BG152449 BM559087 BQ881791 AJ431184 BP342362 
    AI033344 BP356386 BE241847 BX474803 BG761716 BE745086 AI289093 BI260406 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for FUT10 (see all 10)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:        -     -     -     -     -           -     -     -                 -     -                                 
    SP2:                    -     -     -           -     -     -                                                         
    SP3:              -     -     -     -           -     -                                                               
    SP4:              -     -     -     -           -     -     -                 -     -                                 
    SP5:                                            -     -     -                 -     -                                 


    ECgene alternative splicing isoforms for FUT10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUT10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FUT10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUT10

    SOURCE GeneReport for Unigene cluster: Hs.458713
        SABiosciences Expression via Pathway-Focused PCR Array including FUT10: 
              Hematopoiesis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUT10 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FUT101 fucosyltransferase 10 (alpha (1,3) fucosyltransferase) 69.53(n)
    72.09(a)
      395073  NM_204430.1  NP_989761.1 
    lizard
    (Anolis carolinensis)
    Reptilia FUT106
    --
    63(a)
    possible ortholog
    GL343339.1(1146655-1163889)
    zebrafish
    (Danio rerio)
    Actinopterygii fut101 fucosyltransferase 10 60.94(n)
    61.23(a)
      497615  NM_001012374.1  NP_001012374.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta FucTB1 , 3 protein amino acid glycosylation galactoside
    3-L-fucosyltransferase3
    CG4435-PA1
    38(a)3
    50.27(n)1
    40.43(a)1
      30B53
    342601  NM_135444.41  NP_609288.41 


    ENSEMBL Gene Tree for FUT10 (if available)
    TreeFam Gene Tree for FUT10 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUT10 gene
    FUT52  FUT42  FUT72  FUT62  FUT32  FUT112  FUT92  
    1 SIMAP similar gene for FUT10 using alignment to 1 protein entry:     FUT10_HUMAN:
    FUT11

    FUT10 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1867 NCBI SNPs in FUT10 are shown (see all 1867    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1860970931,2
    --33227854(+) GGTGAC/TAGAGC 1 -- ds50010--------
    rs715126701,2
    C,F,--33227919(+) CTGAAG/AGGCTA 1 -- ds50012Minor allele frequency- A:0.50NA 4
    rs1440234961,2
    --33227927(+) CTAAGC/GAAAAT 1 -- ds50010--------
    rs765254681,2
    F,--33228121(+) AGAAAC/TGCTTA 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1509367511,2
    --33228122(+) GAAACA/GCTTAG 1 -- ds50010--------
    rs14740351,2
    C,F,O,H,--33228162(-) CCATCG/TTAGTT 1 -- ds500129Minor allele frequency- N:0.00MN EA NA NS WA 3582
    rs70128731,2
    C,F,H,--33228199(+) TAAGAC/TATACA 1 -- ds500113Minor allele frequency- T:0.09NS EA NA WA 1760
    rs70026041,2
    C,F,H,--33228349(+) TTATAT/CGCAAT 1 -- ut31 ese314Minor allele frequency- C:0.08NS EA NA WA 2060
    rs783945261,2
    C,F,--33228386(+) CCCCCT/CTTCCA 1 -- ut312Minor allele frequency- C:0.07NA EA 240
    rs1908927791,2
    --33228554(+) AAACAC/TCTACA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FUT10 (33228342 - 33330940 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FUT10: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUT10
    DNA2.0 Custom Variant and Variant Library Synthesis for FUT10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FUT10 for disorders           About MalaCards

    FUT10 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: FUT10 (1 document)

    Export disorders for FUT10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUT10 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with FUT10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Comparison of human and mouse Fuc-TX and Fuc-TXI genes, and expression studies in the mouse. (PubMed id 12370785)1, 2 Baboval T. and Smith F.I. (2002)
    3. Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism. (PubMed id 11698403)1, 2 Roos C.... Renkonen R. (2002)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Activity, splice variants, conserved peptide motifs, and phylogeny of two new alpha1,3-fucosyltransferase families (FUT10 and FUT11). (PubMed id 19088067)1 Mollicone R....Oriol R. (2009)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84750 HGNC: 19234 AceView: FUT10 Ensembl:ENSG00000172728 euGenes: HUgn84750
    ECgene: FUT10 H-InvDB: FUT10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUT10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FUT10 gene:
    Search GeneIP for patents involving FUT10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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