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Aliases for FUT1 Gene

Aliases for FUT1 Gene

  • Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, H Blood Group) 2 3
  • H 3 4 6
  • Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase) 2 3
  • GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 1 3 4
  • Blood Group H Alpha 2-Fucosyltransferase 3 4
  • Alpha(1,2)FT 1 3 4
  • EC 2.4.1.69 4 64
  • HSC 3 4
  • HH 3 6
  • Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, Bombay Phenotype Included) 2
  • Galactoside 2-Alpha-L-Fucosyltransferase 1 3
  • Alpha(1,2) Fucosyltransferase 1 3
  • Alpha (1,2) Fucosyltransferase 3
  • 2-Alpha-L-Fucosyltransferase 3
  • Fucosyltransferase 1 4

External Ids for FUT1 Gene

Previous Symbols for FUT1 Gene

  • H
  • HSC

Summaries for FUT1 Gene

Entrez Gene Summary for FUT1 Gene

  • The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUT1 Gene

FUT1 (Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, H Blood Group)) is a Protein Coding gene. Among its related pathways are Metabolism and Glycosphingolipid biosynthesis - ganglio series. GO annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT2.

UniProtKB/Swiss-Prot for FUT1 Gene

  • Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values

Gene Wiki entry for FUT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUT1 Gene

Genomics for FUT1 Gene

Genomic Location for FUT1 Gene

Start:
48,748,011 bp from pter
End:
48,755,390 bp from pter
Size:
7,380 bases
Orientation:
Minus strand

Genomic View for FUT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUT1 Gene

Regulatory Elements for FUT1 Gene

Proteins for FUT1 Gene

  • Protein details for FUT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P19526-FUT1_HUMAN
    Recommended name:
    Galactoside 2-alpha-L-fucosyltransferase 1
    Protein Accession:
    P19526
    Secondary Accessions:
    • O14505
    • O14506
    • O14507

    Protein attributes for FUT1 Gene

    Size:
    365 amino acids
    Molecular mass:
    41251 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively

neXtProt entry for FUT1 Gene

Proteomics data for FUT1 Gene at MOPED

Post-translational modifications for FUT1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn65 and Asn327

Other Protein References for FUT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FUT1 Gene

Gene Families for FUT1 Gene

HGNC:

Protein Domains for FUT1 Gene

UniProtKB/Swiss-Prot:

FUT1_HUMAN
Family:
  • Belongs to the glycosyltransferase 11 family.:
    • P19526
genes like me logo Genes that share domains with FUT1: view

Function for FUT1 Gene

Molecular function for FUT1 Gene

GENATLAS Biochemistry: fucosyltransferase,alpha-(1,2),1 (synthesis of H blood antigen),regulating the expression of ABO antigenes in erythrocyte membranes and related antigens in several tissues
UniProtKB/Swiss-Prot CatalyticActivity: GDP-beta-L-fucose + beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
UniProtKB/Swiss-Prot Function: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values

Enzyme Numbers (IUBMB) for FUT1 Gene

Gene Ontology (GO) - Molecular Function for FUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity TAS 11698403
GO:0008417 fucosyltransferase activity TAS 2118655
genes like me logo Genes that share ontologies with FUT1: view

Phenotypes for FUT1 Gene

genes like me logo Genes that share phenotypes with FUT1: view

miRNA for FUT1 Gene

miRTarBase miRNAs that target FUT1

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FUT1 Gene

Localization for FUT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUT1 Gene

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUT1 Gene COMPARTMENTS Subcellular localization image for FUT1 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
extracellular 2
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus TAS 11698403
GO:0005887 integral component of plasma membrane TAS 2118655
GO:0016020 membrane TAS 2118655
GO:0032580 Golgi cisterna membrane IEA --
genes like me logo Genes that share ontologies with FUT1: view

Pathways for FUT1 Gene

genes like me logo Genes that share pathways with FUT1: view

Pathways by source for FUT1 Gene

UniProtKB/Swiss-Prot P19526-FUT1_HUMAN

  • Pathway: Protein modification; protein glycosylation

Interacting Proteins for FUT1 Gene

Gene Ontology (GO) - Biological Process for FUT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS 2118655
GO:0006486 protein glycosylation TAS 11698403
GO:0036065 fucosylation IBA --
GO:0042355 L-fucose catabolic process NAS 11698403
genes like me logo Genes that share ontologies with FUT1: view

Compounds for FUT1 Gene

(2) HMDB Compounds for FUT1 Gene

Compound Synonyms Cas Number PubMed IDs
GDP-L-fucose
  • GDP-beta-L-fucose
15839-70-0
Guanosine diphosphate
  • 5'-GDP
146-91-8

(1) Novoseek inferred chemical compound relationships for FUT1 Gene

Compound -log(P) Hits PubMed IDs
galactose 36.1 1
genes like me logo Genes that share compounds with FUT1: view

Transcripts for FUT1 Gene

Unigene Clusters for FUT1 Gene

Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUT1 Gene

No ASD Table

Relevant External Links for FUT1 Gene

GeneLoc Exon Structure for
FUT1
ECgene alternative splicing isoforms for
FUT1

Expression for FUT1 Gene

mRNA expression in normal human tissues for FUT1 Gene

mRNA differential expression in normal tissues according to GTEx for FUT1 Gene

This gene is overexpressed in Pancreas (9.8) and Stomach (5.6).

SOURCE GeneReport for Unigene cluster for FUT1 Gene Hs.69747

genes like me logo Genes that share expressions with FUT1: view

Orthologs for FUT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUT1 36
  • 99.36 (n)
  • 98.63 (a)
FUT1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUT1 36
  • 81.71 (n)
  • 78.83 (a)
FUT1 37
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 52 (a)
ManyToMany
FUT1 36
  • 84.2 (n)
  • 83.56 (a)
mouse
(Mus musculus)
Mammalia Fut1 36
  • 77.25 (n)
  • 78.83 (a)
Fut1 16
Fut1 37
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUT1 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUT1 37
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fut1 36
  • 78.03 (n)
  • 77.09 (a)
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 54 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia fut1 36
  • 57.29 (n)
  • 56.23 (a)
Species with no ortholog for FUT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FUT1 Gene

ENSEMBL:
Gene Tree for FUT1 (if available)
TreeFam:
Gene Tree for FUT1 (if available)

Paralogs for FUT1 Gene

Paralogs for FUT1 Gene

genes like me logo Genes that share paralogs with FUT1: view

Variants for FUT1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUT1 Gene

P19526-FUT1_HUMAN
Nonfunctional mutant of FUT1 are the cause of the H-Bombay blood group

Sequence variations from dbSNP and Humsavar for FUT1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4015 -- 48,750,132(-) AGTAC(A/G)TGGCT utr-variant-3-prime
rs4021 -- 48,750,004(-) CTGAA(C/T)ATTCT utr-variant-3-prime
rs838135 -- 48,753,206(-) GAGAC(C/G)CTGGT intron-variant
rs838136 -- 48,753,131(-) TCTCC(A/G)TCCCC intron-variant
rs838137 -- 48,751,316(-) CTCAG(A/C/T)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUT1 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3967n71 CNV Loss 21882294
dgv3968n71 CNV Loss 21882294
nsv912244 CNV Gain 21882294
nsv833855 CNV Loss 17160897
esv2718685 CNV Deletion 23290073

Relevant External Links for FUT1 Gene

HapMap Linkage Disequilibrium report
FUT1
Human Gene Mutation Database (HGMD)
FUT1
Locus Specific Mutation Databases (LSDB)
FUT1
Blood Group Antigen Gene Mutation Database (BGMUT)
Blood Group

Disorders for FUT1 Gene

(5) Novoseek inferred disease relationships for FUT1 Gene

Disease -log(P) Hits PubMed IDs
colon cancer 24.4 4
gastric cancer 0.611 1
metastasis 0 1
tumors 0 4
cancer 0 2

Relevant External Links for FUT1

Genetic Association Database (GAD)
FUT1
Human Genome Epidemiology (HuGE) Navigator
FUT1
genes like me logo Genes that share disorders with FUT1: view

No data available for UniProtKB/Swiss-Prot for FUT1 Gene

Publications for FUT1 Gene

  1. Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles. (PMID: 9122901) Wagner F.F. … Flegel W.A. (Transfusion 1997) 3 4 23
  2. Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. (PMID: 9299444) Koda Y. … Kimura H. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. [Study on the frequency of alpha-1,2-fucosyltransferase gene h4 allele (C35T) in Chinese population]. (PMID: 16331565) Xu X.G. … Yan L.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005) 3 23 49
  4. Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1. (PMID: 17459061) MejA-as-Luque R. … de BolA^s C. (Cancer Sci. 2007) 3 23
  5. [Molecular genetic analysis of FUT1 and FUT2 gene in para-Bombay Chinese: a novel FUT1 allele is identified]. (PMID: 17922418) Su Y.q. … Li D.C. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007) 3 23

Products for FUT1 Gene

Sources for FUT1 Gene

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