Aliases for FUT1 Gene
External Ids for FUT1 Gene
Previous HGNC Symbols for FUT1 Gene
Previous GeneCards Identifiers for FUT1 Gene
This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016]
GeneCards Summary for FUT1 Gene
FUT1 (Fucosyltransferase 1 (H Blood Group)) is a Protein Coding gene. Diseases associated with FUT1 include Cd45 Deficiency. Among its related pathways are Glycosphingolipid biosynthesis - ganglio series and Glycosphingolipid biosynthesis - globo series. GO annotations related to this gene include fucosyltransferase activity and galactoside 2-alpha-L-fucosyltransferase activity. An important paralog of this gene is FUT2.
UniProtKB/Swiss-Prot for FUT1 Gene
Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values.