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FUT1 Gene

protein-coding   GIFtS: 60
GCID: GC19M049251

Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase,...

(Previous names: fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase,...)
(Previous symbols: H, HSC)
  Search for FUT1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, H Blood
Group)1 2
     HH2 5
H1 2 3 5     Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase, Bombay
Phenotype Included)1
HSC1 2 3     2-alpha-L-fucosyltransferase2
Fucosyltransferase 1 (Galactoside 2-Alpha-L-Fucosyltransferase)1 2     Alpha (1,2) Fucosyltransferase2
Alpha(1,2)FT 12 3     Alpha(1,2) Fucosyltransferase 12
Blood Group H Alpha 2-Fucosyltransferase2 3     Galactoside 2-Alpha-L-Fucosyltransferase 12
GDP-L-Fucose:Beta-D-Galactoside 2-Alpha-L-Fucosyltransferase 12 3     Fucosyltransferase 13
EC 2.4.1.693 8     

External Ids:    HGNC: 40121   Entrez Gene: 25232   Ensembl: ENSG000001749517   OMIM: 2111005   UniProtKB: P195263   

Export aliases for FUT1 gene to outside databases

Previous GC identifers: GC19M049964 GC19M049619 GC19M053927 GC19M053943 GC19M045630


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FUT1 Gene:
The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor
of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This
gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of
the H-Bombay blood group. (provided by RefSeq, Jul 2008)

GeneCards Summary for FUT1 Gene:
FUT1 (fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)) is a protein-coding gene. GO annotations related to this gene include galactoside 2-alpha-L-fucosyltransferase activity and fucosyltransferase activity. An important paralog of this gene is FUT2.

UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526
Function: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an
essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes
fucosylate the same acceptor substrates but exhibit different Km values

Gene Wiki entry for FUT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FUT1 gene promoter:
         PPAR-gamma1   p300   MyoD   STAT3   PPAR-gamma2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUT1 promoter sequence
   Search Chromatin IP Primers for FUT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

FUT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUT1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049251:  view genomic region     (about GC identifiers)

Start:
49,251,268 bp from pter      End:
49,258,647 bp from pter
Size:
7,380 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526 (See protein sequence)
Recommended Name: Galactoside 2-alpha-L-fucosyltransferase 1  
Size: 365 amino acids; 41251 Da
Miscellaneous: There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase. They are
expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin
respectively
Secondary accessions: O14505 O14506 O14507

Explore the universe of human proteins at neXtProt for FUT1: NX_P19526

Explore proteomics data for FUT1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn65, Asn327
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FUT1 (P19526) (see all 19)
     LAPVFRI  EFTLHDH  AAFLPEW  PVFVVTS 


    See FUT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000139.1  
    ENSEMBL proteins: 
     ENSP00000312021  

    FUT1 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FUT: Fucosyltransferases
    bloodgroup: Blood group antigens

    1 InterPro protein domain:
     IPR002516 Glyco_trans_11

    Graphical View of Domain Structure for InterPro Entry P19526

    ProtoNet protein and cluster: P19526

    1 Blocks protein domain: IPB002516 Glycosyl transferase

    UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526
    Similarity: Belongs to the glycosyltransferase 11 family


    Find genes that share domains with FUT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUT1_HUMAN, P19526
    Function: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an
    essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes
    fucosylate the same acceptor substrates but exhibit different Km values
    Catalytic activity: GDP-beta-L-fucose +
    beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
    = GDP +
    alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

         Genatlas biochemistry entry for FUT1:
    fucosyltransferase,alpha-(1,2),1 (synthesis of H blood antigen),regulating the expression of ABO antigenes in
    erythrocyte membranes and related antigens in several tissues

         Enzyme Number (IUBMB): EC 2.4.1.691 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008107galactoside 2-alpha-L-fucosyltransferase activity TAS11698403
    GO:0008417fucosyltransferase activity TAS2118655
         
    Find genes that share ontologies with FUT1           About GenesLikeMe


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Fut1):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with FUT1           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FUT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FUT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FUT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FUT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target FUT1:
    hsa-mir-132-3p (MIRT021792)

    Block miRNA regulation of human, mouse, rat FUT1 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate FUT1:
    hsa-miR-1178 hsa-miR-125a-5p hsa-miR-125b hsa-miR-670 hsa-miR-767-3p hsa-miR-513a-5p hsa-miR-1291 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidFUT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FUT1
    Predesigned siRNA for gene silencing in human, mouse, rat FUT1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for FUT1 (see all 7)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FUT1 (NM_000148)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT1

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FUT1_HUMAN, P19526: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
    Note=Membrane-bound form in trans cisternae of Golgi
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane4
    extracellular2
    endoplasmic reticulum1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005794Golgi apparatus TAS11698403
    GO:0005887integral component of plasma membrane TAS2118655
    GO:0016020membrane TAS2118655
    GO:0032580Golgi cisterna membrane IEA--

    Find genes that share ontologies with FUT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FUT1 About    
    See pathways by source

    SuperPathContained pathways About
    1Glycosphingolipid biosynthesis - ganglio series
    Ganglio Sphingolipid Metabolism0.53
    2Metabolism
    Metabolic pathways0.38
    3Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - lacto and neolacto series
    4Glycosphingolipid biosynthesis - globo series
    Glycosphingolipid biosynthesis - globo series


    Find genes that share SuperPaths with FUT1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for FUT1
        Ganglio Sphingolipid Metabolism


    3 Kegg Pathways  (Kegg details for FUT1):
        Glycosphingolipid biosynthesis - lacto and neolacto series
    Glycosphingolipid biosynthesis - globo series
    Metabolic pathways

    UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526
    Pathway: Protein modification; protein glycosylation

        Pathway & Disease-focused RT2 Profiler PCR Array including FUT1: 

              Mesenchymal Stem Cell in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FUT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for FUT1 (ENSP000003120214) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B3GALT5ENSP000003433184STRING: ENSP00000343318
    B3GNT2ENSP000003055954STRING: ENSP00000305595
    B3GNT4ENSP000003196364STRING: ENSP00000319636
    B4GALT1ENSP000003690554STRING: ENSP00000369055
    B4GALT2ENSP000003492934STRING: ENSP00000349293
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process TAS2118655
    GO:0006486protein glycosylation TAS11698403
    GO:0036065fucosylation ----
    GO:0042355L-fucose catabolic process NAS11698403

    Find genes that share ontologies with FUT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FUT1

    2 HMDB Compounds for FUT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    GDP-L-fucoseGDP-beta-L-fucose (see all 5)15839-70-0--
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--

    1 Novoseek inferred chemical compound relationship for FUT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    galactose 36.1 1 11479278 (1)



    Find genes that share compounds with FUT1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FUT1 gene: 
    NM_000148.3  

    Unigene Cluster for FUT1:

    Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
    Hs.69747  [show with all ESTs]
    Unigene Representative Sequence: NM_000148
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000310160(uc002pkk.3 uc002pkl.1 uc002pkm.1) ENST00000601931
    ENST00000599826 ENST00000597220 ENST00000601988
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate FUT1:
    hsa-miR-1178 hsa-miR-125a-5p hsa-miR-125b hsa-miR-670 hsa-miR-767-3p hsa-miR-513a-5p hsa-miR-1291 hsa-miR-4319
    SwitchGear 3'UTR luciferase reporter plasmidFUT1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FUT1
    Clone
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    GenScript: all cDNA clones in your preferred vector: FUT1 (NM_000148)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUT1
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat FUT1
      QuantiFast Probe-based Assays in human, mouse, rat FUT1

    Additional mRNA sequence: 

    BC074732.2 D87935.1 D87936.1 D87937.1 D87938.1 D87939.1 D87940.1 D87941.1 
    M35531.1 

    3 DOTS entries:

    DT.411909  DT.121451256  DT.100787200 

    Selected AceView cDNA sequences (see all 41):

    M35531 BC074732 CA435895 NM_000148 R91944 AA781233 CA454198 D87939 
    AI910408 BU631184 BF196142 BM851542 D87935 BM789542 D87936 D87938 
    D87941 D87937 BM790913 AW664940 BX489705 BF439550 CK023853 AI761182 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FUT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTAGGCT
    FUT1 Expression
    About this image

    FUT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FUT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.69747
        Pathway & Disease-focused RT2 Profiler PCR Array including FUT1: 
              Mesenchymal Stem Cell in human mouse rat

    Primer
    Products:
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FUT1 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fut11 , 5 fucosyltransferase 11, 5 77.25(n)1
    78.83(a)1
      7 (29.39 cM)5
    143431  NM_008051.61  NP_032077.21 
     456176065 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    54(a)
    1 → many
    GL343329.1(853192-856474)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia fut11 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, more 57.29(n)
    56.23(a)
      447958  NM_001004772.1  NP_001004772.1 


    ENSEMBL Gene Tree for FUT1 (if available)
    TreeFam Gene Tree for FUT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FUT1 gene
    FUT22  
    4 SIMAP similar genes for FUT1 using alignment to 18 protein entries:     FUT1_HUMAN (see all proteins):
    h2    h1    sej    FUT2

    Find genes that share paralogs with FUT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    FUT1_HUMAN, P19526: Nonfunctional mutant of FUT1 are the cause of the H-Bombay blood group


    Selected SNPs for FUT1 (see all 331)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1048946861,2
    Cpathogenic149430147(-) GCCTAC/GCTGGC 2 Y * stg10--------
    rs1048946881,2
    Cpathogenic149430269(-) CCTCCC/TAGGGC 2 Q * stg10--------
    rs289345881,2,,4
    Cpathogenic149430370(-) CTACCG/TCCGGC 2 R L mis1 ese30--------
    rs1048946871,2
    Cpathogenic149430604(-) GAAGCA/TCTCTG 2 H L mis10--------
    rs8381311,2
    C,F,A,H--45639487(-) CGGGGT/GGTCTC 1 -- us2k114Minor allele frequency- G:0.48EA NA MN WA CSA 690
    rs1415874461,2
    --49427501(+) TGAAAC/TCCCGT 1 -- ds50010--------
    rs1851499521,2
    --49427661(+) AGACTC/TGATCT 1 -- ds50010--------
    rs1907919361,2
    --49427678(+) AAAAAC/TAAATT 1 -- ds50010--------
    rs1462161001,2
    --49427688(+) TAATTA/TAAAAA 1 -- ds50010--------
    rs2004600541,2
    C--49427688(+) TAATT-/AAAAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for FUT1 (49251268 - 49258647 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for FUT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718685CNV Deletion23290073
    nsv833855CNV Loss17160897
    dgv3967n71CNV Loss21882294
    dgv3968n71CNV Loss21882294
    nsv912244CNV Gain21882294
    nsv9739CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): FUT1
    Locus Specific Mutation Databases (LSDB): FUT1

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FUT1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 211100    OMIM disorders: --


    Find genes that share disorders with FUT1           About GenesLikeMe

    5 Novoseek inferred disease relationships for FUT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon cancer 24.4 4 17459061 (2), 12652076 (2)
    gastric cancer 0.611 1 9054453 (1)
    metastasis 0 1 17897065 (1)
    tumors 0 5 18205178 (2), 14742243 (1), 9054453 (1)
    cancer 0 3 14742243 (1), 9054453 (1)

    Genetic Association Database (GAD): FUT1
    Human Genome Epidemiology (HuGE) Navigator: FUT1 (3 documents)

    Export disorders for FUT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FUT1 gene, integrated from 10 sources (see all 93):
    (articles sorted by number of sources associating them with FUT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. (PubMed id 9299444)1, 2, 9 Koda Y.... Kimura H. (Biochem. Biophys. Res. Commun. 1997)
    2. [Study on the frequency of alpha-1,2-fucosyltransferase gene h4 allele (C35T) in Chinese population]. (PubMed id 16331565)1, 4, 9 Xu X.G....Yan L.X. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2005)
    3. Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles. (PubMed id 9122901)1, 2, 9 Wagner F.F. and Flegel W.A. (Transfusion 1997)
    4. Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese. (PubMed id 15487706)1, 4 Chen D.P....Sun C.F. (Ann. Clin. Lab. Sci. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Wide variety of point mutations in the H gene of Bombay and para- Bombay individuals which inactivate H enzyme. (PubMed id 9226185)1, 2 Kaneko M.... Narimatsu H. (Blood 1997)
    7. Molecular basis for H blood group deficiency in Bombay (Oh) and para- Bombay individuals. (PubMed id 7912436)1, 2 Kelly R.J....Lowe J.B. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    8. Molecular cloning, sequence, and expression of a human GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. (PubMed id 2118655)1, 2 Larsen R.D.... Lowe J.B. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    9. Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA. (PubMed id 9054453)1, 9 Koda Y....Kimura H. (J. Biol. Chem. 1997)
    10. [Molecular genetic analysis of FUT1 and FUT2 gene in para-Bombay Chinese: a novel FUT1 allele is identified]. (PubMed id 17922418)1, 9 Su Y.q....Li D.C. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2523 HGNC: 4012 AceView: FUT1 Ensembl:ENSG00000174951 euGenes: HUgn2523
    ECgene: FUT1 Kegg: 2523 H-InvDB: FUT1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FUT1 Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=hh
    GGDBhttp://jcggdb.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT1
    SeattleSNPshttp://pga.gs.washington.edu/data/fut1/
    Functional Glycomics Gateway - GTasehttp://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_598

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FUT1 gene:
    Search GeneIP for patents involving FUT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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