FUT1 Gene
protein-coding GIFtS : 62
GC19M053943
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) (Previous names: fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included), fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase) )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbols: H, HSC )
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Aliases & Descriptions for FUT1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases 2-alpha-L-fucosyltransferase 2 EC 2.4.1.69 3 H 2 , 3 , 5 HH 2 , 5 HSC 2 , 3
Descriptions Alpha(1,2)FT 1 3 Blood group H alpha 2-fucosyltransferase 2 , 3 Fucosyltransferase 1 2 , 3 GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 2 , 3 alpha (1,2) fucosyltransferase 2 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase) 1 , 2 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, Bombay phenotype included) 1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2 galactoside 2-alpha-L-fucosyltransferase 1 2
Search outside databases for aliases for FUT1 genePrevious GC identifers: GC19M049964 GC19M049619 GC19M053927
Summaries for FUT1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for FUT1 : The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creationof a precursor of the H antigen, which is required for the final step in the soluble A and Bantigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferaseenzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq] UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526 Function : Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the Hantigen which is an essential substrate for the final step in the soluble A and B antigensynthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit differentKm values
Gene Wiki entry for FUT1
Genomic Location for FUT1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the FUT1 gene Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.1-qter FUT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19M053943:
(about GC identifiers )
Start:
53,943,080 bp from pter
End:
53,950,459 bp from pter
Size:
7,380 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000019.8 NT_011109.15 Proteins for FUT1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526 (See
protein sequence )Recommended Name: Galactoside 2-alpha-L-fucosyltransferase 1 Size : 365 amino acids; 41251 Da
Subcellular location : Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.Note=Membrane-bound form in trans cisternae of Golgi
Miscellaneous : There are two genes (FUT1 and FUT2) which encode galactoside 2-L-fucosyltransferase.They are expressed in a tissue-specific manner with expression restricted to cells of mesodermalor endodermal origin respectively
Secondary accessions : O14505 O14506 O14507
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins: NP_000139.1 ENSEMBL proteins: ENSP00000312021 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for FUT1: Assays for FUT1:
Protein
Domains/ Families for FUT1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P19526 ProtoNet protein and cluster: P19526
1 Blocks protein family : IPB002516 Glycosyl transferase UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526 Similarity : Belongs to the glycosyltransferase 11 family
Gene Function for FUT1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000148 Applied Biosystems Silencer ® siRNAs for FUT1 Sigma-Aldrich siRNA and siRNA Panels for FUT1 Sigma-Aldrich shRNA for FUT1 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000148                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000148                                  untagged cDNA clone in CMV expression vector: NM_000148  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000148 UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526 Function : Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the Hantigen which is an essential substrate for the final step in the soluble A and B antigensynthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit differentKm values Catalytic activity : GDP-beta-L-fucose +beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide= GDP +alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide Enzyme Number (IUBMB): EC 2.4.1.69
Genatlas biochemistry entry for FUT1 :fucosyltransferase,alpha-(1,2),1 (synthesis of H blood antigen),regulating the expression of ABOantigenes in erythrocyte membranes and related antigens in several tissues
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fut1) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity
TAS 11698403 GO:0008417 fucosyltransferase activity
TAS 2118655 GO:0016757 transferase activity, transferring glycosyl groups
IEA --
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Pathways & Interactions for FUT1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for FUT1 (Your Favorite Gene powered by Ingenuity) UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526 Pathway : Protein modification; protein glycosylation
Gene Network CentralTM Interacting Genes and Proteins Network for FUT1 5/32 Interacting proteins for FUT1 (ENSP00000312021 3 ) via UniProtKB, MINT, and/or STRING (see all 32
)About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for FUT1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for FUT1 1 Novoseek chemical compound relationship for FUT1 gene
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
galactose
37.46
1
11479278 (1)
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Transcripts for FUT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000148 Sigma-Aldrich siRNA and siRNA Panels for FUT1 Sigma-Aldrich shRNA for FUT1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_000148
REFSEQ mRNAs for FUT1 gene: NM_000148.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000148
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000148                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000148                                  untagged cDNA clone in CMV expression vector: NM_000148  
Additional cDNA sequence: BC074732.2 D87935.1 D87936.1 D87937.1 D87938.1 D87939.1 D87940.1 D87941.1 M35531.1
3 DOTS entries : DT.411909 DT.121451256 DT.100787200
24/41 AceView cDNA sequences (see all 41
):NM_000148 CA435895 BC074732 M35531 BX489705 BM789542 AW664940 AA781233 D87935 CK023853 BM790913 CA454198 D87936 R91944 D87939 BU631184 D87941 BF439550 BF196142 D87938 AI910408 BM851542 D87937 AW673250
highest scoring ESTs for FUT1 :D87939 M35531 AA781233 AA826450 AA879118 AI033355 AI150080 AI248629 AI399809 AI694703
Unigene Cluster for FUT1: Fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) Hs.69747 [show with all ESTs ] Unigene Representative Sequence: NM_000148 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000310160
Expression for FUT1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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FUT1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for FUT1 1 / 2 / 3
3 probe-sets matching FUT1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CCTGTAGGCTSOURCE GeneReport for Unigene cluster: Hs.69747
Orthologs for FUT1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for FUT1 gene from 5 species
About this table Species with no ortholog for FUT1 ENSEMBL Gene Tree for FUT1 Paralogs for FUT1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for FUT1 gene FUT2 2
SNPs/Variants for FUT1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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UniProtKB/Swiss-Prot: FUT1_HUMAN, P19526 Polymorphism : Nonfunctional mutant of FUT1 are the cause of the H-Bombay blood group
HapMap Linkage Disequilibrium images for FUT1 (up to first 250kb)
Disorders & Mutations for FUT1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 211100
5 Novoseek disease relationships for FUT1 gene
About this table Blood Group Antigen Gene Mutation Database (BGMUT) H blood group system Human Gene Mutation Database : FUT1 Genetic Association Database: FUT1 Human Genome Epidemiology Navigator: FUT1 (2 documents)
Medical News for FUT1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for FUT1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/76 PubMed articles for FUT1 gene (see all 76
): Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system. (PubMed id 9299444) 1, 3, 4 Koda Y.... Kimura H. (1997) [Study on the frequency of alpha-1,2-fucosyltransferase gene h4 allele (C35T) in Chinese population] (PubMed id 16331565) 1, 3, 6 Xu X.G....Yan L.X. (2005) Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles. (PubMed id 9122901) 1, 3, 4 Wagner F.F. and Flegel W.A. (1997) Two prevalent h alleles in para-Bombay haplotypes among 250,000 Taiwanese. (PubMed id 15487706) 3, 6 Chen D.P....Sun C.F. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Wide variety of point mutations in the H gene of Bombay and para- Bombay individuals which inactivate H enzyme. (PubMed id 9226185) 3, 4 Kaneko M.... Narimatsu H. (1997) Molecular basis for H blood group deficiency in Bombay (Oh) and para- Bombay individuals. (PubMed id 7912436) 3, 4 Kelly R.J....Lowe J.B. (1994) Molecular cloning, sequence, and expression of a human GDP-L- fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen. (PubMed id 2118655) 3, 4 Larsen R.D.... Lowe J.B. (1990) Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA. (PubMed id 9054453) 1, 3 Koda Y....Kimura H. (1997) [Molecular genetic analysis of FUT1 and FUT2 gene in para-Bombay Chinese: a novel FUT1 allele is identified] (PubMed id 17922418) 1, 3 Su Y....Li D.C. (2007)
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Genome Databases showing FUT1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing FUT1
(According to HUGE )
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Specialized Databases showing FUT1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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Name Description
dbRBC/BGMUT http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=hh GGDB http://riodb.ibase.aist.go.jp/rcmg/ggdb/Homolog?cat=symbol&symbol=FUT1 SeattleSNPs http://pga.gs.washington.edu/data/fut1/ Functional Glycomics Gateway - GTase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_598
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-- Services for FUT1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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