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FUS Gene

protein-coding GIFtS: 63

GC16P031098

fusion (involved in t(12;16) in malignant liposarcoma)
(Previous names: fusion, derived from t(12;16) malignant liposarcoma )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CHOP ^²
FUS-CHOP ^²
FUS1 ^¹, ²
POMp75 ^³
TLS ^¹, ², ³, ⁵
TLS/CHOP ^²
hnRNP-P2 ^¹, ²

Descriptions
75 kDa DNA-pairing protein ^³
FUS-CHOP fusion protein ^²
FUS-CHOP protein fusion ^²
Fusion gene in myxoid liposarcoma ^²
Oncogene FUS ^³
Oncogene TLS ^³
Translocated in liposarcoma protein ^³
fus-like protein ^²
fus/tls-chop oncogene ^²
fusion (involved in t(12;16) in malignant liposarcoma) ^²
fusion, derived from t(12;16) malignant liposarcoma ^¹
heterogeneous nuclear ribonucleoprotein P2 ^²
translocated in liposarcoma ^²

External Ids
HGNC: 4010¹
Entrez Gene: 2521²
UniProtKB: P35637³
Ensembl: ENSG00000089280⁷

Search outside databases for aliases for FUS gene

Previous GC identifers: GC16P030273 GC16P031688 GC16P031188 GC16P031227

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637

Function: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing

of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA.

May play a role in maintenance of genomic integrity

Gene Wiki entry for FUS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FUS gene

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

FUS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P031098: (about GC identifiers)

Start:	31,098,954 bp from pter
End:	31,110,601 bp from pter
Size:	11,648 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000016.8 NT_010393.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637 (See protein sequence)

Recommended Name: RNA-binding protein FUS

Size: 526 amino acids; 53426 Da

Subunit: Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts

through its C-terminus with FUSIP1

Subcellular location: Nucleus

Secondary accessions: Q9H4A8

Alternative splicing: 2 isoforms: P35637-1 P35637-2

Post-translational modifications:

Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004951.1

ENSEMBL proteins:

ENSP00000369594 ENSP00000346746 ENSP00000254108

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (TLS/FUS)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: FUS

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	TAS	8510758
GO:0005730	NOT nucleolus	IDA	18029348

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Antibodies for FUS:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FUS
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (TLS/FUS), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FUS)
	Novus Biologicals Antibodies for FUS

Assays for FUS:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P35637

ProtoNet protein and cluster: P35637

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB001876 Zn-finger

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637

Similarity: Belongs to the RRM TET family

Similarity: Contains 1 RanBP2-type zinc finger

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FUS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FUS)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001010850

Applied Biosystems Silencer® siRNAs for FUS

Sigma-Aldrich siRNA for FUS

Sigma-Aldrich shRNA for FUS

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FUS
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004960
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004960
untagged cDNA clones in CMV expression vector (see all 3): NM_001010850

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004960

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637

Function: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing

of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA.

May play a role in maintenance of genomic integrity

Genatlas biochemistry entry for FUS:

RNA binding protein,highly homologous to EWS1,glycine-rich,regulator of BCR/ABL-mediated

leukemogenesis,rearranged in myxoid liposarcoma with translocation t(12;16) and in myeloid

leukemia with translocation t(16;21)(q13;p11)

11 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fus):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	hematopoietic system
immune system	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system
reproductive system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	TAS	8510758
GO:0005515	protein binding	IPI	9774382
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for FUS

5/148 Interacting proteins for FUS (P35637^{1, 2} ENSP00000254108³) via UniProtKB, MINT, and/or STRING (see all 148 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FUSIP1	O75494², ENSP00000344149³	MINT-15493 STRING (score=.987)
SF3A2	Q15428², ENSP00000221494³	MINT-5206070 STRING (score=.951)
PRMT1	Q99873², ENSP00000246789³	MINT-63692 STRING (score=.912)
SFPQ	P23246², ENSP00000349748³	MINT-62325 STRING (score=.864)
EIF6	P56537¹	EBI-400434, EBI-372243

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	nuclear mRNA splicing, via spliceosome	EXP	12226669

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FUS
2 Novoseek chemical compound relationships for FUS gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	25.43	2	7987849 (1)
zinc	0.00	2	12594223 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FUS)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FUS)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001010850

Sigma-Aldrich siRNA for FUS

Sigma-Aldrich shRNA for FUS

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004960

REFSEQ mRNAs for FUS gene:

NM_004960.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004960

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004960
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004960
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001010850

Additional cDNA sequence:

AB208902.1 AJ301611.1 AJ301612.1 AK098774.1 AK130774.1 AK290936.1 AK299129.1 AK301110.1

BC000402.2 BC002459.1 BC026062.2 BC051293.1 BT007131.1 CR456747.1 CR591758.1 CR598388.1

CR599479.1 CR602284.1 CR608658.1 CR615094.1 CR616248.1 CR618073.1 CR618104.1 CR621237.1

CR626089.1 CR626591.1 S62138.1 S62140.1 S75762.1 U00942.1 U36561.1 X71428.1

24/55 DOTS entries (see all 55 ):

DT.448733 DT.100876813 DT.95338699 DT.95305442 DT.100876818 DT.100876810 DT.40119887 DT.219776

DT.92413530 DT.95291133 DT.100876827 DT.120687296 DT.100798892 DT.120687278 DT.120687255 DT.100876817

DT.95190305 DT.120687153 DT.120687284 DT.40217294 DT.100761904 DT.100876816 DT.102840280 DT.120687164

24/933 AceView cDNA sequences (see all 933 ):

BQ720219 T32210 BM466247 AW248715 AA278178 AI655141 AA356876 AI074537

AI887609 BM471477 BM823701 AA315059 BM853646 CR618073 CR626591 BU538492

BE613463 BE206200 AA412717 BM692760 BQ054145 BI914071 BQ216384 CB134354

highest scoring ESTs for FUS:

S62140 AA001940 AA001956 AA159528 AA160721 AA232483 AA279979 AA315059 AA356876 AA383497

Unigene Cluster for FUS:

Fusion (involved in t(12;16) in malignant liposarcoma)

Hs.513522 [show with all ESTs]

Unigene Representative Sequence: AB208902

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000380244 ENST00000354711 ENST00000254108

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FUS expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FUS

¹ / ² / ³

15 probe-sets matching FUS gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
63941_at²^{, 3}	U95-C	1	1.00	1.00	0.47	0.85	AI971708	0.60	1.00	0.82	1
43501_at²^{, 3}	U95-B	1	1.00	1.00	0.89	0.79	AL042575	0.60	1.00	0.82	1
39180_at²^{, 3}	U95-A	2	1.00	0.94	0.75	1.39	S62140	1.00	1.00	1.00	1
61744_r_at²^{, 3}	U95-C	2	0.56	0.56	0.73	0.99	AA934889	0.40	1.00	0.76	1
200959_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004960	0.60	1.00	0.82	1
217370_x_at²^{, 3}	U133-A	5	1.00	0.37	--	--	S75762	0.40	1.00	0.76	1
231108_at²^{, 3}	U133-B	1	0.91	1.00	--	--	H43040	0.20	1.00	0.72	1
215744_at²^{, 3}	U133-A	1	0.36	1.00	--	--	AW514140	0.60	1.00	0.82	1
200959_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1565717_s_at²	U133Plus2	2	1.00	0.50	--	--	--	--	--	--	--
217370_x_at²	U133Plus2	5	1.00	0.37	--	--	--	--	--	--	--
231108_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
215744_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--
1565715_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--
1565716_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks FUS for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGGGGTAACT

SOURCE GeneReport for Unigene cluster: Hs.513522
Expression variation in blood from EXPOLDB for FUS
UniProtKB/Swiss-Prot: FUS_HUMAN, P35637
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FUS gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	FUS¹	--	fusion (involved in t(12;16) in malignant liposarcoma)	99.04(n) 98.84(a)	742385 XM_001158561.1 XP_001158561.1
cow (Bos taurus)	FUS¹	--	fusion (involved in t(12;16) in malignant liposarcoma)	91.13(n) 96.28(a)	280796 NM_173912.1 NP_776337.1
rat (Rattus norvegicus)	Fus¹	--	fusion, derived from t(12;16) malignant liposarcoma more	89.77(n) 97.28(a)	317385 NM_001012137.1 NP_001012137.1
mouse (Mus musculus)	Fus^{1, 5}	7⁵	fusion, derived from t(12;16) malignant liposarcoma more^{1, 5}	90.29(n)¹ 97.67(a)¹	233908¹ NM_139149.2¹ NP_631888.1¹ AF224264⁵ AK032815⁵ (see all 24)
zebrafish (Danio rerio)	zgc56390²	--	similar to pigpen	73.03(n)	394058 BC049308.1

About this table Species with no ortholog for FUS

ENSEMBL Gene Tree for FUS

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FUS gene

TAF15² EWSR1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/82 NCBI SNPs in FUS are shown (see all 82 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 35)

AB	SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs929867^1,2	C,F,H	31098983(-)	`CTGAGC/TACCGA`	1	--	ut5¹ ese³		8	MN EU EA WA NA	744
	rs4889537^1,2	C,F,H	31111030(+)	`GGCTTG/CAGGTC`	1	--	ng3¹		15	EU EA WA NA	1400
	rs7194882^1,2	C,H	31098422(+)	`AACCCC/TGAAAG`	1	--	ng5¹		3	EU EA	282
	rs9888851^1,2	F,H	31098873(+)	`TCCTGC/TCTCCC`	1	--	ng5¹		4	EU EA WA	418
	rs3764326^1,2	F,H	31098039(-)	`GAAAGT/CGAGAC`	1	--	ng5¹		4	EU EA WA	416
	rs1052352^1,2	A,C,F,H	31102780(+)	`TCCTAT/CCCTGG`	1	Y/Y	syn¹ ese³		9	EA EU WA	2130
	rs741810^1,2	A,C,F,H	31101443(+)	`TCAGGC/ATATGG`	1	G/G	syn¹		5	MN EU EA WA	582
--	rs2735393^1,2	C,F,O	31103606(+)	`TGTTTT/CAGCTT`	1	--	int¹		4	EA NA	214
	rs11860916^1,2	C,H	31099679(+)	`CGGTGG/TTCAGG`	1	--	int¹		4	EU EA WA	412
	rs13331793^1,2	F,H	31109698(+)	`GCTGGG/TACCAA`	1	--	int¹		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for FUS (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 137070

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637

A chromosomal aberration involving FUS is a cause of a form of malignant myxoid

liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3

A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML).

Translocation t(16;21)(p11;q22) with ERG

A chromosomal aberration involving FUS is associated with angiomatoid fibrous histiocytoma

(AFH) [MIM:612160]. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1

protein

Defects in FUS are the cause of amyotrophic lateral sclerosis type 6 (ALS6) [MIM:608030].

ALS6 is a familial form of amyotrophic lateral sclerosis. ALS is a neurodegenerative disorder

affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal

cord, resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within

2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial,

involving both genetic and environmental factors. The disease is inherited in 5-10%

10/12 Novoseek disease relationships for FUS gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
liposarcoma myxoid	95.31	15	18162764 (3), 7566973 (2), 9244875 (1), 19190116 (1) (see all 11)
liposarcoma	87.10	15	8058726 (2), 15064749 (2), 15492825 (2), 18509338 (1) (see all 11)
sarcoma clear cell	62.32	2	7493135 (1), 11063792 (1)
ewings sarcoma	60.16	3	12907633 (2), 7493135 (1)
sarcoma	59.91	9	18162764 (3), 12915480 (2), 10602519 (1), 18620564 (1) (see all 5)
histiocytoma fibrous	58.31	2	11063792 (1), 12915480 (1)
lipoma	52.34	1	9244875 (1)
chondrosarcoma	48.78	3	18162764 (3)
tumors	37.17	13	17486070 (1), 18551309 (1), 19190116 (1), 7493135 (1) (see all 10)
chromosomal aberrations	9.91	2	8058726 (2)

About this table

Genatlas disease: FUS

myxoid and round cell subtype liposarcoma,with breakpoint in t(12;16)(q13;p11) translocation

GeneTests: FUS

Amyotrophic Lateral Sclerosis

Human Gene Mutation Database: FUS
Human Genome Epidemiology Navigator: FUS (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/94 PubMed articles for FUS gene (see all 94 ):

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. (PubMed id 7503811)^{1, 2, 3, 4} Rabbitts T.H....Nathan P. (1993)
Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell prolifieration. (PubMed id 10442642)^{1, 3, 4} Bertrand P.... Lopez B.S. (1999)
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. (PubMed id 19251628)^{3, 4} Vance C....Shaw C.E. (2009)
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. (PubMed id 19251627)^{3, 4} Kwiatkowski T.J. Jr.... Brown R.H. Jr. (2009)
Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)^{3, 4} Ong S.E.... Mann M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation. (PubMed id 10567410)^{3, 4} Baechtold H.... Akhmedov A.T. (1999)
Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. (PubMed id 9774382)^{3, 4} Yang L.... Hickstein D.D. (1998)
Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. (PubMed id 9795213)^{3, 4} Morohoshi F....Ohki M. (1998)
The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription. (PubMed id 9660765)^{3, 4} Zhang D.... Childs G. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 2521	HGNC: 4010	AceView: FUS	Ensembl:ENSG00000089280	euGenes: HUgn2521
ECgene: FUS	H-InvDB: FUS

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for FUS	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for FUS
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
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Enzo Life Sciences, and/or Tocris Bioscience)
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Products for FUS:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

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Antibodies for FUS

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FUS Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for FUS

Summaries
for FUS

Genomic Location
for FUS

Proteins
for FUS

Protein Domains/
Families
for FUS

Gene Function
for FUS

Pathways & Interactions
for FUS

Drugs & Compounds
for FUS

Transcripts
for FUS

Expression
for FUS

Orthologs
for FUS

Paralogs
for FUS

SNPs/Variants
for FUS

Disorders & Mutations
for FUS

Medical News
for FUS

Publications
for FUS

Search for FUS

Genome Databases showing FUS

Other Databases showing FUS

Specialized Databases showing FUS

Licensable Technologies
for FUS

Services
for FUS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FUS (Gene Symbol)
CHOP
FUS-CHOP
FUS1
POMp75
TLS
TLS/CHOP
hnRNP-P2
75 kDa DNA-pairing protein
FUS-CHOP fusion protein
FUS-CHOP protein fusion
Fusion gene in myxoid liposarcoma
Oncogene FUS
Oncogene TLS
Translocated in liposarcoma protein
fus-like protein
fus/tls-chop oncogene
fusion (involved in t(12;16) in malignant liposarcoma)
fusion, derived from t(12;16) malignant liposarcoma
heterogeneous nuclear ribonucleoprotein P2
translocated in liposarcoma

FUS Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor FUS

Summariesfor FUS

Genomic Locationfor FUS

Proteinsfor FUS

Protein Domains/Familiesfor FUS

Gene Functionfor FUS

Pathways & Interactionsfor FUS

Drugs & Compoundsfor FUS

Transcriptsfor FUS

Expression for FUS

Orthologsfor FUS

Paralogsfor FUS

SNPs/Variantsfor FUS

Disorders & Mutationsfor FUS

Medical Newsfor FUS

Publicationsfor FUS

Search for FUS

Genome Databases showing FUS

Other Databases showing FUS

Specialized Databases showing FUS

Licensable Technologiesfor FUS

Servicesfor FUS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FUS

Summaries
for FUS

Genomic Location
for FUS

Proteins
for FUS

Protein Domains/
Families
for FUS

Gene Function
for FUS

Pathways & Interactions
for FUS

Drugs & Compounds
for FUS

Transcripts
for FUS

Expression
for FUS

Orthologs
for FUS

Paralogs
for FUS

SNPs/Variants
for FUS

Disorders & Mutations
for FUS

Medical News
for FUS

Publications
for FUS

Licensable Technologies
for FUS

Services
for FUS