Aliases for FUS Gene
External Ids for FUS Gene
Previous Symbols for FUS Gene
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
GeneCards Summary for FUS Gene
FUS (FUS RNA Binding Protein) is a Protein Coding gene. Diseases associated with FUS include liposarcoma and amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia. Among its related pathways are Translational Control and Transcriptional misregulation in cancer. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is EWSR1.
UniProtKB/Swiss-Prot for FUS Gene
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity