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FUS Gene

protein-coding   GIFtS: 68
GCID: GC16P031191

Fused In Sarcoma

(Previous names: fusion, derived from t(12;16) malignant liposarcoma, amyotrophic...)
(Previous symbol: ALS6)
  See FUS-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fused In Sarcoma1 2     Fusion (Involved In T(12;16) In Malignant Liposarcoma)1
ALS61 2 5     Fusion, Derived From T(12;16) Malignant Liposarcoma1
TLS2 3 5     Translocated In Liposarcoma1
Heterogeneous Nuclear Ribonucleoprotein P21 2     FUS12
Oncogene FUS2 3     HNRNPP22
Oncogene TLS2 3     POMP752
Translocated In Liposarcoma Protein2 3     Fus-Like Protein2
75 KDa DNA-Pairing Protein2 3     Fusion Gene In Myxoid Liposarcoma2
ETM42 5     RNA-Binding Protein FUS2
Amyotrophic Lateral Sclerosis 61     POMp753

External Ids:    HGNC: 40101   Entrez Gene: 25212   Ensembl: ENSG000000892807   OMIM: 1370705   UniProtKB: P356373   

Export aliases for FUS gene to outside databases

Previous GC identifers: GC16P030273 GC16P031688 GC16P031188 GC16P031227 GC16P031098 GC16P028753


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FUS Gene:
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP)
complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the
cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular
processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA
processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in
amyotrophic lateral sclerosis type 6. (provided by RefSeq, Sep 2009)

GeneCards Summary for FUS Gene:
FUS (fused in sarcoma) is a protein-coding gene. Diseases associated with FUS include amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia, and tremor, hereditary essential, 4. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is TAF15.

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637
Function: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of
complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in
maintenance of genomic integrity

Gene Wiki entry for FUS Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_187260.1  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FUS gene promoter:
         NRSF form 1   FOXO1a   STAT5A   NRSF form 2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUS promoter sequence
   Search Chromatin IP Primers for FUS

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

FUS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUS gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031191:  view genomic region     (about GC identifiers)

Start:
31,191,431 bp from pter      End:
31,206,192 bp from pter
Size:
14,762 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FUS_HUMAN, P35637 (See protein sequence)
Recommended Name: RNA-binding protein FUS  
Size: 526 amino acids; 53426 Da
Subunit: Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its
C-terminus with SFRS13A. Interacts with OTUB1 and SARNP
4 PDB 3D structures from and Proteopedia for FUS:
2LA6 (3D)        2LCW (3D)        4FDD (3D)        4FQ3 (3D)    
Secondary accessions: Q9H4A8
Alternative splicing: 2 isoforms:  P35637-1   P35637-2   

Explore the universe of human proteins at neXtProt for FUS: NX_P35637

Explore proteomics data for FUS at MOPED

Post-translational modifications: 

  • Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine1
  • Ubiquitination2 at Lys316, Lys365
  • Modification sites at PhosphoSitePlus

  • See FUS Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001164105.1  NP_001164408.1  NP_004951.1  

    ENSEMBL proteins: 
     ENSP00000254108   ENSP00000455073   ENSP00000369594   ENSP00000455282  
    Reactome Protein details: P35637

    FUS Human Recombinant Protein Products:

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    Novus Biologicals FUS Protein
    Novus Biologicals FUS Lysate
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for FUS

     
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    FUS Antibody Products:

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    Novus Biologicals FUS Antibodies
    Abcam antibodies for FUS
    Cloud-Clone Corp. Antibodies for FUS
    ThermoFisher Antibody for FUS
    LSBio Antibodies in human, mouse, rat for FUS

    FUS Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for FUS
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for FUS
    Cloud-Clone Corp. CLIAs for FUS
    Search eBioscience for ELISAs for FUS 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR001876 Znf_RanBP2
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry P35637

    ProtoNet protein and cluster: P35637

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001876 Zn-finger


    UniProtKB/Swiss-Prot: FUS_HUMAN, P35637
    Similarity: Belongs to the RRM TET family
    Similarity: Contains 1 RanBP2-type zinc finger
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with FUS           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUS_HUMAN, P35637
    Function: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of
    complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in
    maintenance of genomic integrity

         Genatlas biochemistry entry for FUS:
    RNA binding protein,highly homologous to EWS1,glycine-rich,regulator of BCR/ABL-mediated leukemogenesis,rearranged
    in myxoid liposarcoma with translocation t(12;16) and in myeloid leukemia with translocation t(16;21)(q13;p11)

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding IEA--
    GO:0003723RNA binding TAS8510758
    GO:0005515protein binding IPI18954305
         
    Find genes that share ontologies with FUS           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FUS:
     Decreased influenza A virus in  Increased cell number in G2M,  

         10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Fus):
     behavior/neurological  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     immune system  mortality/aging  nervous system  no phenotypic analysis  reproductive system 

    Find genes that share phenotypes with FUS           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FUS
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FUS

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FUS
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FUS

    miRNA
    Products:
        
    miRTarBase miRNAs that target FUS:
    hsa-mir-1260b (MIRT052707), hsa-mir-221-3p (MIRT046900), hsa-mir-125b-5p (MIRT046086), hsa-mir-331-3p (MIRT043384), hsa-mir-615-3p (MIRT040469), hsa-mir-10a-5p (MIRT047505), hsa-mir-1296-5p (MIRT036115), hsa-mir-664a-3p (MIRT035826), hsa-mir-197-3p (MIRT004196), hsa-mir-181b-5p (MIRT047277)

    Block miRNA regulation of human, mouse, rat FUS using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FUS (see all 17):
    hsa-miR-320a hsa-miR-520d-5p hsa-miR-202 hsa-miR-200a hsa-miR-3916 hsa-miR-3125 hsa-miR-4275 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidFUS 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for FUS
    Predesigned siRNA for gene silencing in human, mouse, rat FUS

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FUS

    Clone
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    OriGene clones in human, mouse for FUS (see all 14)
    OriGene ORF clones in mouse, rat for FUS
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FUS (NM_004960)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUS
    Addgene plasmids for FUS 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for FUS
    Browse ESI BIO Cell Lines and PureStem Progenitors for FUS 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUS


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FUS_HUMAN, P35637: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton2
    cytosol2
    chloroplast1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with FUS           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FUS About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA Splicing - Major Pathway0.78
    mRNA Splicing0.78
    Processing of Capped Intron-Containing Pre-mRNA0.78
    mRNA processing0.44
    2Gene Expression
    Gene Expression0.40
    3Translational Control
    Translational Control
    4Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer
    5Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with FUS           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for FUS
        Chromatin Regulation / Acetylation
    Translational Control

    1 BioSystems Pathway for FUS
        mRNA processing

    1 Reactome Pathway for FUS
        mRNA Splicing - Major Pathway


    1 Kegg Pathway  (Kegg details for FUS):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FUS: 
              Neurotrophins & Receptors in human mouse rat
              Necrosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FUS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FUS (P356371, 2, 3 ENSP000002541084) via UniProtKB, MINT, STRING, and/or I2D (see all 944)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SRRM1Q8IYB32, 3, ENSP000003262614MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000326261
    ZMYM2Q9UBW72, 3, ENSP000003723224MINT-62324 MINT-62321 I2D: score=3 STRING: ENSP00000372322
    PTBP1P265992, 3, ENSP000003494284MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000349428
    SF3A2Q154282, 3, ENSP000002214944MINT-5206070 MINT-7947479 I2D: score=1 STRING: ENSP00000221494
    SRSF10O754942, 3, ENSP000004201954MINT-15493 I2D: score=4 STRING: ENSP00000420195
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000398mRNA splicing, via spliceosome TAS--
    GO:0008219cell death IEA--
    GO:0008380RNA splicing TAS--
    GO:0010467gene expression TAS--

    Find genes that share ontologies with FUS           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FUS

    2 Novoseek inferred chemical compound relationships for FUS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 24.4 2 7987849 (1)
    zinc 0 2 12594223 (2)



    Find genes that share compounds with FUS           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FUS gene (4 alternative transcripts): 
    NM_001170634.1  NM_001170937.1  NM_004960.3  NM_001010850.1  

    Unigene Cluster for FUS:

    Fused in sarcoma
    Hs.46894  [show with all ESTs]
    Unigene Representative Sequence: NM_004960
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000254108(uc002ebh.3 uc002ebe.2 uc002ebf.3 uc002ebg.3)
    ENST00000566605 ENST00000487045(uc010vfi.2) ENST00000380244 ENST00000487509
    ENST00000568685 ENST00000487974 ENST00000570090 ENST00000474990(uc010caj.1)
    ENST00000568901 ENST00000564766 ENST00000569760 ENST00000483853
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FUS (see all 17):
    hsa-miR-320a hsa-miR-520d-5p hsa-miR-202 hsa-miR-200a hsa-miR-3916 hsa-miR-3125 hsa-miR-4275 hsa-miR-141
    SwitchGear 3'UTR luciferase reporter plasmidFUS 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FUS
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): FUS (NM_004960)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUS
    Addgene plasmids for FUS 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for FUS
    OriGene qSTAR qPCR primer pairs in human, mouse for FUS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FUS
      QuantiTect SYBR Green Assays in human, mouse, rat FUS
      QuantiFast Probe-based Assays in human, mouse, rat FUS

    Additional mRNA sequence: 

    AJ301611.1 AJ301612.1 AK098774.1 AK130774.1 AK290936.1 AK299129.1 AK301110.1 BC000402.2 
    BC002459.1 BC026062.2 BC051293.1 BT007131.1 CR456747.1 GU933437.1 NR_028388.2 S62140.1 
    U36561.1 X71428.1 

    Selected DOTS entries (see all 57):

    DT.448733  DT.100876813  DT.95338699  DT.95305442  DT.100876818  DT.100876810  DT.92413530  DT.40119887 
    DT.219776  DT.95291133  DT.100876827  DT.120687296  DT.100798892  DT.120687278  DT.120687255  DT.100876817 
    DT.120687153  DT.120687164  DT.120687284  DT.40217294  DT.95190305  DT.100761904  DT.102840280  DT.75128804 

    Selected AceView cDNA sequences (see all 933):

    AA054825 AA515194 BQ961516 AA412717 BM478221 CR599479 BX117216 W02207 
    BM721947 AA278178 CR618104 AA368847 CR598388 AW026653 BU151582 BQ049524 
    AI887609 AA315059 BQ446807 BM853646 AW516001 AI131076 T06961 AA383497 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FUS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGTAACT
    FUS Expression
    About this image


    FUS expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 23) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mandibular Condyle
     
     Tooth (Integumentary System)    fully expand to see all 3 entries
             Inner Enamel Epithelial Cells Dental Enamel
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Epithelial Cells
             Inner Enamel Epithelial Cells Dental Enamel
    FUS Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FUS Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.46894

    UniProtKB/Swiss-Prot: FUS_HUMAN, P35637
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including FUS: 
              Neurotrophins & Receptors in human mouse rat
              Necrosis in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for FUS
    OriGene qSTAR qPCR primer pairs in human, mouse for FUS
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat FUS
    QuantiTect SYBR Green Assays in human, mouse, rat FUS
    QuantiFast Probe-based Assays in human, mouse, rat FUS
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUS

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FUS gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fus5 fusion, derived from t(12;16) malignant liposarcoma more   --   7 (69.87 cM) 127967457 
    lizard
    (Anolis carolinensis)
    Reptilia FUS6
    fused in sarcoma
    84(a)
    1 ↔ 1
    GL343220.1(2260486-2273600)
    African clawed frog
    (Xenopus laevis)
    Amphibia fus-prov2 fusion, derived from t(12;16) malignant liposarcoma more 78.63(n)    BC044319.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563902 similar to pigpen 73.03(n)   394058  BC049308.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta caz6
    CG147186
    --
    42(a)
    25(a)
    many ↔ many
    many ↔ many
    X(16182879-16187553)
    3R(7526336-7528442)


    ENSEMBL Gene Tree for FUS (if available)
    TreeFam Gene Tree for FUS (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FUS gene
    TAF152  EWSR12  
    3 SIMAP similar genes for FUS using alignment to 5 protein entries:     FUS_HUMAN (see all proteins):
    TAF15    EWSR1    RBM3

    Find genes that share paralogs with FUS           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FUS (see all 540)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1865473811,2,,4
    CTremor, hereditary essential 4 (ETM4)4 --32202913(+) TAATCC/TGTGAG 7 P L mis11Minor allele frequency- T:0.00EU 1323
    VAR_0548434
    Amyotrophic lateral sclerosis 6 (ALS6)4--see VAR_0548432 R C mis40--------
    VAR_0548404
    Amyotrophic lateral sclerosis 6 (ALS6)4--see VAR_0548402 G C mis40--------
    VAR_0548484
    Amyotrophic lateral sclerosis 6 (ALS6)4--see VAR_0548482 R T mis40--------
    VAR_0689194
    Tremor, hereditary essential 4 (ETM4)4--see VAR_0689192 R C mis40--------
    VAR_0689204
    Amyotrophic lateral sclerosis 6 (ALS6)4--see VAR_0689202 G V mis40--------
    VAR_0548454
    Amyotrophic lateral sclerosis 6 (ALS6)4--see VAR_0548452 R H mis40--------
    VAR_0354814
    A breast cancer sample4--see VAR_0354812 K Q mis40--------
    VAR_0548444
    Amyotrophic lateral sclerosis 6 (ALS6)4--see VAR_0548442 R G mis40--------
    VAR_0689184
    Amyotrophic lateral sclerosis 6 (ALS6)4--see VAR_0689182 G S mis40--------

    HapMap Linkage Disequilibrium report for FUS (31191431 - 31206192 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FUS:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905729CNV Loss21882294
    dgv2670n71CNV Loss21882294
    nsv457483CNV Loss19166990
    dgv2672n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): FUS
    Locus Specific Mutation Databases (LSDB): FUS

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FUS
    DNA2.0 Custom Variant and Variant Library Synthesis for FUS

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 137070   
    OMIM disorders: 608030  614782  
    UniProtKB/Swiss-Prot: FUS_HUMAN, P35637
  • Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma.
    Translocation t(12;16)(q13;p11) with DDIT3
  • Note=A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation
    t(16;21)(p11;q22) with ERG
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma
    that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic
    microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of
    hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a
    lymph node metastasis. Note=The disease may be caused by mutations affecting the gene represented in this entry.
    A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation
    t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein
  • Amyotrophic lateral sclerosis 6 (ALS6) [MIM:608030]: A neurodegenerative disorder affecting upper motor
    neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis.
    Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal
    tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and
    deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be
    multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.
    Note=The disease is caused by mutations affecting the gene represented in this entry
  • Tremor, hereditary essential 4 (ETM4) [MIM:614782]: A common movement disorder mainly characterized by
    postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The
    condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional
    disability or even incapacitation. Inheritance is autosomal dominant. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • Selected diseases for FUS (see all 22):    
    About MalaCards
    amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia    tremor, hereditary essential, 4    fus-related amyotrophic lateral sclerosis    myxoid liposarcoma
    mixed-type liposarcoma    amyotrophic lateral sclerosis type 6    expressive language disorder    spondylolysis
    liposarcoma    tremor    combined factor v and viii deficiency    amyotrophic lateral sclerosis 2, juvenile
    myxofibrosarcoma    pleomorphic liposarcoma    amyotrophic lateral sclerosis with frontotemporal dementia    lateral sclerosis
    amyotrophic lateral sclerosis    histiocytoma    frontotemporal dementia    essential tremor

    11 diseases from the University of Copenhagen DISEASES database for FUS:
    Amyotrophic lateral sclerosis     Liposarcoma     Frontotemporal dementia     Sarcoma
    Fibrous histiocytoma     Anomalous atrioventricular excitation     Aphasia     Progressive supranuclear palsy
    Spondylolysis     Peripheral primitive neuroectodermal tumor     Expressive language disorder

    Find genes that share disorders with FUS           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FUS gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liposarcoma myxoid 95 15 18162764 (3), 7566973 (2), 9244875 (1), 19190116 (1) (see all 11)
    liposarcoma 87.6 16 8058726 (2), 15064749 (2), 15492825 (2), 18509338 (1) (see all 12)
    sarcoma clear cell 61.6 2 7493135 (1), 11063792 (1)
    sarcoma 60.9 10 18162764 (3), 12915480 (2), 10602519 (1), 20406182 (1) (see all 6)
    ewings sarcoma 59 3 12907633 (2), 7493135 (1)
    histiocytoma fibrous 57.1 2 11063792 (1), 12915480 (1)
    lipoma 51.2 1 9244875 (1)
    chondrosarcoma 47.6 3 18162764 (3)
    tumors 36.9 13 17486070 (1), 18551309 (1), 19190116 (1), 7493135 (1) (see all 10)
    chromosomal aberrations 8.79 2 8058726 (2)

    Genatlas disease: FUS
    myxoid and round cell subtype liposarcoma,with breakpoint in t(12;16)(q13;p11) translocation

    GeneTests: FUS
    GeneReviews: FUS
    Genetic Association Database (GAD): FUS
    Human Genome Epidemiology (HuGE) Navigator: FUS (18 documents)

    Export disorders for FUS gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FUS gene, integrated from 10 sources (see all 276):
    (articles sorted by number of sources associating them with FUS)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. (PubMed id 7503811)1, 2, 3, 9 Rabbitts T.H.... Nathan P. (Nat. Genet. 1993)
    2. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. (PubMed id 19251628)1, 2, 3 Vance C....Shaw C.E. (Science 2009)
    3. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. (PubMed id 19251627)1, 2, 3 Kwiatkowski T.J. Jr.... Brown R.H. Jr. (Science 2009)
    4. Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation. (PubMed id 10442642)1, 2, 9 Bertrand P.... Lopez B.S. (Oncogene 1999)
    5. Exome sequencing identifies fus mutations as a cause of essential tremor. (PubMed id 22863194)1, 2 Merner N.D.... Rouleau G.A. (Am. J. Hum. Genet. 2012)
    6. C-terminal FUS/TLS mutations in familial and sporadic ALS in Germany. (PubMed id 20018407)1, 4 Drepper C....Sendtner M. (Neurobiol. Aging 2011)
    7. Fus gene mutations in familial and sporadic amyotrophic lateral sclerosis. (PubMed id 20544928)1, 4 Rademakers R....Mackenzie I.R. (amp 2010)
    8. Novel missense and truncating mutations in FUS/TLS in familial ALS. (PubMed id 20660363)1, 4 Waibel S....Ludolph A.C. (Neurology 2010)
    9. Novel FUS/TLS mutations and pathology in familial and sporadic amyotrophic lateral sclerosis. (PubMed id 20385912)1, 4 Hewitt C....Shaw P.J. (Arch. Neurol. 2010)
    10. SOD1, ANG, VAPB, TARDBP, and FUS mutations in familial amyotrophic lateral sclerosis: genotype-phenotype correlations. (PubMed id 20577002)1, 4 Millecamps S....Meininger V. (J. Med. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 2521 HGNC: 4010 AceView: FUS Ensembl:ENSG00000089280 euGenes: HUgn2521
    ECgene: FUS Kegg: 2521 H-InvDB: FUS

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FUS Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FUS Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FUS gene:
    Search GeneIP for patents involving FUS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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