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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

FUS Gene

protein-coding GIFtS: 66
GCID: GC16P031191

fused in sarcoma

(Previous names: fusion, derived from t(12;16) malignant liposarcoma, amyotrophic...)
(Previous symbol: ALS6)

Explore 42 diseases affiliated with
FUS via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Fused In Sarcoma¹ ²		Fusion, Derived From T(12;16) Malignant Liposarcoma¹
TLS¹ ² ³ ⁵		HnRNP-P2¹
ALS6¹ ² ⁵		ETM4²
FUS1¹ ²		HNRNPP2²
Oncogene FUS² ³		POMP75²
Oncogene TLS² ³		Fus-Like Protein²
Translocated In Liposarcoma Protein² ³		Fusion Gene In Myxoid Liposarcoma²
75 KDa DNA-Pairing Protein² ³		Heterogeneous Nuclear Ribonucleoprotein P2²
Amyotrophic Lateral Sclerosis 6¹		RNA-Binding Protein FUS²
Fusion (Involved In T(12;16) In Malignant Liposarcoma)¹		POMp75³

External Ids:	HGNC: 4010¹	Entrez Gene: 2521²	Ensembl: ENSG00000089280⁷	OMIM: 137070⁵	UniProtKB: P35637³

ORGUL members:
	NONCODE:n408227

Export aliases for FUS gene to outside databases

Previous GC identifers: GC16P030273 GC16P031688 GC16P031188 GC16P031227 GC16P031098 GC16P028753

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FUS:

This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex.

The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This

protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that

include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative

splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.

(provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637

Function: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary

single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of

genomic integrity

Gene Wiki entry for FUS

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010393.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the FUS gene promoter:
NRSF form 1 FOXO1a STAT5A NRSF form 2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: FUS promoter sequence

Search SABiosciences Chromatin IP Primers for FUS

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUS

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2 Ensembl cytogenetic band: 16p11.2 HGNC cytogenetic band: 16p11.2

FUS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUS gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P031191: view genomic region (about GC identifiers)

Start:	31,191,431 bp from pter	End:	31,206,192 bp from pter
Size:	14,762 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637 (See protein sequence)

Recommended Name: RNA-binding protein FUS

Size: 526 amino acids; 53426 Da

Subunit: Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its

C-terminus with SFRS13A. Interacts with OTUB1 and SARNP

Subcellular location: Nucleus

3 PDB 3D structures from and Proteopedia for FUS:

2LA6 (3D)

2LCW (3D)

4FDD (3D)

Secondary accessions: Q9H4A8

Alternative splicing: 2 isoforms: P35637-1 P35637-2

Explore the universe of human proteins at neXtProt for FUS: NX_P35637

Post-translational modifications:

Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P35637

FUS Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001164105.1 NP_001164408.1 NP_004951.1

ENSEMBL proteins:

ENSP00000254108 ENSP00000455073 ENSP00000369594 ENSP00000455282

Reactome Protein details: P35637
Human Recombinant Protein Products for FUS:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: FUS OriGene Protein Over-expression Lysate: FUS OriGene Custom Protein Services for FUS
	GenScript Custom Purified and Recombinant Proteins Services for FUS
	Novus Biologicals FUS Protein Novus Biologicals FUS Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for FUS

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005730	NOT nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--

FUS for ontologies About GeneDecksing

FUS Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of FUS
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	Cell Signaling Technology (CST) Antibodies for FUS (hnRNP P2)
	OriGene Antibodies (see all 2): FUS OriGene Custom Antibody Services for FUS
	GenScript Superior Antibodies for FUS
	Novus Biologicals FUS Antibodies
	Abcam antibodies for FUS
	Uscn Antibodies for FUS
	ThermoFisher Antibody for FUS

Assay Products for FUS:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for FUS
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for FUS

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

FUS for domains About GeneDecksing

3 InterPro domains/families:

IPR012677 Nucleotide-bd_a/b_plait

IPR001876 Znf_RanBP2

IPR000504 RRM_dom

Graphical View of Domain Structure for InterPro Entry P35637

ProtoNet protein and cluster: P35637

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB001876 Zn-finger

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637

Similarity: Belongs to the RRM TET family

Similarity: Contains 1 RanBP2-type zinc finger

Similarity: Contains 1 RRM (RNA recognition motif) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: FUS_HUMAN, P35637

Function: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary

single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of

genomic integrity

Genatlas biochemistry entry for FUS:

RNA binding protein,highly homologous to EWS1,glycine-rich,regulator of BCR/ABL-mediated leukemogenesis,rearranged in

myxoid liposarcoma with translocation t(12;16) and in myeloid leukemia with translocation t(16;21)(q13;p11)

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003676	nucleic acid binding	--	--
GO:0003677	DNA binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	--

FUS for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for FUS:

Decreased influenza A virus in

Increased cell number in G2M,

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Fus):

behavior/neurological	cellular	endocrine/exocrine gland	growth/size	hematopoietic system
immune system	mortality/aging	nervous system	reproductive system

FUS for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for FUS

miRNA Products:		miRTarBase miRNAs that target FUS: hsa-mir-197 (MIRT004196)

		OriGene 3'-UTR Clone: FUS Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FUS
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FUS (see all 17):
		hsa-miR-320a hsa-miR-520d-5p hsa-miR-202 hsa-miR-200a hsa-miR-3916 hsa-miR-3125 hsa-miR-4275 hsa-miR-141

		SwitchGear 3'UTR luciferase reporter plasmid: FUS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUS (see all 7) OriGene shRNA RFP: FUS OriGene siRNA: FUS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUS
		Sirion Biotech Custom design and validation of potent shRNA sequences against FUS

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for FUS
			Sirion Biotech Customized adenovirus for overexpression of FUS Sirion Biotech Customized adenovirus for potent knockdown of FUS

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUS (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUS (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FUS (NM_004960)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for FUS
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUS

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for FUS
		Search LifeMap BioReagents cell lines for FUS
		Sirion Biotech Customized stable knockdown cell line services for FUS Sirion Biotech Customized inducible knockdown cell line services for FUS Sirion Biotech Customized stable overexpressing cell line services for FUS Sirion Biotech Customized inducible overexpressing cell line services for FUS

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUS

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

mRNA Splicing - Major Pathway

mRNA Splicing - Major Pathway	1.00	mRNA Processing	0.82
mRNA Splicing	1.00	mRNA processing	0.48
Processing of Capped Intron-Containing Pre-mRNA	0.96

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Translational Control

Translational Control

1.00

Generic Transcription Pathway

Gene Expression

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for FUS

	Chromatin Regulation / Acetylation
	Translational Control

1 BioSystems Pathway for FUS

mRNA processing

5 Reactome Pathways for FUS

	mRNA Splicing - Major Pathway
	mRNA Splicing
	Gene Expression
	mRNA Processing
	Processing of Capped Intron-Containing Pre-mRNA

FUS for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for FUS

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/900 Interacting proteins for FUS (P35637^{1, 2, 3} ENSP00000254108⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 900)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SRSF10	O75494²^,³, ENSP00000420195⁴	MINT-15493 I2D: score=4 STRING: ENSP00000420195
SRRM1	Q8IYB3²^,³, ENSP00000326261⁴	MINT-7945693 MINT-7947479 I2D: score=3 STRING: ENSP00000326261
ZMYM2	Q9UBW7²^,³, ENSP00000372322⁴	MINT-62324 MINT-62321 I2D: score=3 STRING: ENSP00000372322
PTBP1	P26599²^,³, ENSP00000349428⁴	MINT-7945693 MINT-7947479 I2D: score=2 STRING: ENSP00000349428
SF3A2	Q15428²^,³, ENSP00000221494⁴	MINT-5206070 MINT-7947479 I2D: score=1 STRING: ENSP00000221494

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000398	mRNA splicing, via spliceosome	TAS	--
GO:0008219	cell death	IEA	--
GO:0008380	RNA splicing	TAS	--
GO:0010467	gene expression	TAS	--

FUS for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

FUS for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for FUS
2 Novoseek chemical compound relationships for FUS gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leucine	24.4	2	7987849 (1)
zinc	0	2	12594223 (2)

Search CenterWatch for drugs/clinical trials and news about FUS

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for FUS gene (4 alternative transcripts):

NM_001170634.1 NM_001170937.1 NM_004960.3 NM_001010850.1

Unigene Cluster for FUS:

Fused in sarcoma

Hs.46894 [show with all ESTs]

Unigene Representative Sequence: NM_004960

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000254108(uc002ebh.3 uc002ebe.2 uc002ebf.3 uc002ebg.3)

ENST00000566605 ENST00000487045(uc010vfi.2) ENST00000380244 ENST00000487509

ENST00000568685 ENST00000487974 ENST00000570090 ENST00000474990(uc010caj.1)

ENST00000568901 ENST00000564766 ENST00000569760 ENST00000483853

miRNA Products:		OriGene 3'-UTR Clone: FUS Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat FUS
		8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate FUS (see all 17):
		hsa-miR-320a hsa-miR-520d-5p hsa-miR-202 hsa-miR-200a hsa-miR-3916 hsa-miR-3125 hsa-miR-4275 hsa-miR-141

		SwitchGear 3'UTR luciferase reporter plasmid: FUS 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUS (see all 7) OriGene shRNA RFP: FUS OriGene siRNA: FUS
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUS
		Sirion Biotech Custom design and validation of potent shRNA sequences against FUS

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUS (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUS (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): FUS (NM_004960)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUS

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUS Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUS

Additional cDNA sequence:

AJ301611.1 AJ301612.1 AK098774.1 AK130774.1 AK290936.1 AK299129.1 AK301110.1 BC000402.2

BC002459.1 BC026062.2 BC051293.1 BT007131.1 CR456747.1 GU933437.1 NR_028388.2 S62140.1

U36561.1 X71428.1

24/58 DOTS entries (see all 58):

DT.448733 DT.100876813 DT.95338699 DT.95305442 DT.100876818 DT.100876810 DT.92413530 DT.40119887

DT.219776 DT.95291133 DT.100876827 DT.120687296 DT.100798892 DT.120687278 DT.120687255 DT.100876817

DT.120687153 DT.120687164 DT.120687284 DT.40217294 DT.95190305 DT.100761904 DT.102840280 DT.75128804

24/933 AceView cDNA sequences (see all 933):

AA356876 BF108540 AA992828 BF448249 BU553243 BQ070184 BE206200 BX644127

T32210 BU538492 BE884362 BE264440 BE790896 BU784371 N66916 BM466247

BI333818 AI887609 AA281539 BE742270 AI074537 AW516001 BU730076 CR621237

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

FUS expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGGTAACT

About this image

FUS expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Bone

Bone

Kidney

Reproductive System

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See FUS Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FUS

SOURCE GeneReport for Unigene cluster: Hs.46894

UniProtKB/Swiss-Prot: FUS_HUMAN, P35637

Tissue specificity: Ubiquitous

SABiosciences Expression via Pathway-Focused PCR Arrays including FUS:

Neurotrophins & Receptors in human mouse rat

Necrosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUS Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat FUS
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUS
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUS

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUS

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for FUS gene from 8/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	FUS¹	fused in sarcoma	72.01(n) 82.55(a)		414144 NM_001001531.1 NP_001001531.1
lizard (Anolis carolinensis)	Reptilia	FUS⁶	--	84(a)	1 ↔ 1	GL343220.1(2263718-2272284)
African clawed frog (Xenopus laevis)	Amphibia	fus-prov²	fusion, derived from t(12;16) malignant liposarcoma more	78.63(n)		BC044319.1
zebrafish (Danio rerio)	Actinopterygii	zgc56390²	similar to pigpen	73.03(n)		394058 BC049308.1
fruit fly (Drosophila melanogaster)	Insecta	caz¹	cabeza	56.36(n) 54.62(a)		32587 NM_078641.3 NP_523365.2
worm (Caenorhabditis elegans)	Secernentea	fust-1¹	Protein FUST-1	49.05(n) 46.59(a)		174175 NM_063082.3 NP_495483.1
thale cress (Arabidopsis thaliana)	eudicotyledons	TAF15b¹	TBP-associated factor 15B	44.34(n) 37(a)		835960 NM_180884.1 NP_851215.1
rice (Oryza sativa)	Liliopsida	Os01g0164400¹	hypothetical protein	48.21(n) 41.92(a)		4324412 NM_001048636.1 NP_001042101.1

ENSEMBL Gene Tree for FUS (if available)
TreeFam Gene Tree for FUS (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for FUS gene

TAF15² EWSR1²

3 SIMAP similar genes for FUS using alignment to 5 protein entries: FUS_HUMAN (see all proteins):

TAF15 EWSR1 RBM3

FUS for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs121909668^1,2	C	pathogenic	31202739(+)	`AGGATC/G/TGCAGG`	11	R G C	nc-transcript-variantmis¹		0	--	--	--	--
rs200572272^1,2		--	31189442(+)	`AGTGT-/CCCCCC`	4	--	us2k¹		0	--	--	--	--
rs80014547^1,2	C,F	--	31189447(+)	`CCCCCC/AAAAAA`	4	--	us2k¹		2		WA CSA	4
rs9925407^1,2	C	--	31189448(+)	`CCCCCC/AAAAAA`	4	--	us2k¹ tfbs³ trp³		1		WA	2
rs184249915^1,2		--	31189561(+)	`TGTTAC/GCTATT`	4	--	us2k¹		0	--	--	--	--
rs11641808^1,2	H	--	31189636(+)	`ttgagA/Ccagtc`	4	--	us2k¹		0	--	--	--	--
rs188982138^1,2		--	31189752(+)	`GATTAC/TAGATG`	4	--	us2k¹		0	--	--	--	--
rs181703162^1,2		--	31189948(+)	`GTACAC/TGAATG`	4	--	us2k¹		0	--	--	--	--
rs73530269^1,2	C	--	31189973(+)	`AGAACA/CGTGCC`	4	--	us2k¹		2		WA	120
rs187152034^1,2		--	31190029(+)	`AATAAA/GGGTGG`	4	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for FUS (31191431 - 31206192 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FUS: --
Human Gene Mutation Database (HGMD): FUS

Locus Specific Mutation Databases (LSDB): FUS

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUS

DNA2.0 Custom Variant and Variant Library Synthesis for FUS

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

FUS for disorders           About GeneDecksing

OMIM gene information: 137070
OMIM disorders: 608030
UniProtKB/Swiss-Prot: FUS_HUMAN, P35637

Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma.

Translocation t(12;16)(q13;p11) with DDIT3

Note=A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation

t(16;21)(p11;q22) with ERG

Defects in FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of

malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular

subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately

associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory

cells, mimicking a lymph node metastasis. Note=A chromosomal aberration involving FUS is found in a patient with

angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein

Defects in FUS are the cause of amyotrophic lateral sclerosis type 6 (ALS6) [MIM:608030]. ALS6 is a familial

form of amyotrophic lateral sclerosis. ALS is a neurodegenerative disorder affecting upper motor neurons in the brain

and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are

absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be

multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10%

Defects in FUS are the cause of tremor, hereditary essential 4 (ETM4) [MIM:614782]. A common movement disorder

mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be

involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a

functional disability or even incapacitation. Inheritance is autosomal dominant

20/42 diseases for FUS (see all 42): About MalaCards

amyotrophic lateral sclerosis lateral sclerosis amyotrophic lateral sclerosis type 6 amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia

liposarcoma myxoid liposarcoma anomalous atrioventricular excitation extraskeletal myxoid chondrosarcoma

frontotemporal dementia peripheral primitive neuroectodermal tumor amyotrophic lateral sclerosis (als) sarcoma

myxoid chondrosarcoma fibrous histiocytoma malignant fibrous histiocytoma primitive neuroectodermal tumor

histiocytoma pleomorphic liposarcoma chondrosarcoma lipoma

9 diseases from the University of Copenhagen DISEASES database for FUS:

Amyotrophic lateral sclerosis Liposarcoma Frontotemporal dementia Sarcoma

Fibrous histiocytoma Anomalous atrioventricular excitation Aphasia Spondylolysis

Progressive supranuclear palsy

10/12 Novoseek disease relationships for FUS gene (see all 12) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
liposarcoma myxoid	95	15	18162764 (3), 7566973 (2), 9244875 (1), 19190116 (1) (see all 11)
liposarcoma	87.6	16	8058726 (2), 15064749 (2), 15492825 (2), 18509338 (1) (see all 12)
sarcoma clear cell	61.6	2	7493135 (1), 11063792 (1)
sarcoma	60.9	10	18162764 (3), 12915480 (2), 10602519 (1), 20406182 (1) (see all 6)
ewings sarcoma	59	3	12907633 (2), 7493135 (1)
histiocytoma fibrous	57.1	2	11063792 (1), 12915480 (1)
lipoma	51.2	1	9244875 (1)
chondrosarcoma	47.6	3	18162764 (3)
tumors	36.9	13	17486070 (1), 18551309 (1), 19190116 (1), 7493135 (1) (see all 10)
chromosomal aberrations	8.79	2	8058726 (2)

Genatlas disease: FUS

myxoid and round cell subtype liposarcoma,with breakpoint in t(12;16)(q13;p11) translocation

GeneTests: FUS

Amyotrophic Lateral Sclerosis

Human Genome Epidemiology (HuGE) Navigator: FUS (18 documents)

Export disorders for FUS gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for FUS gene, integrated from 9 sources (see all 221):
(articles sorted by number of sources associating them with FUS)

Utopia: connect your pdf to the dynamic
world of online information

Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. (PubMed id 7503811)^{1, 2, 3, 9} Rabbitts T.H.... Nathan P. (1993)
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. (PubMed id 19251628)^{1, 2, 3} Vance C....Shaw C.E. (2009)
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. (PubMed id 19251627)^{1, 2, 3} Kwiatkowski T.J. Jr.... Brown R.H. Jr. (2009)
Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell prolifieration. (PubMed id 10442642)^{1, 2, 9} Bertrand P.... Lopez B.S. (1999)
Exome sequencing identifies fus mutations as a cause of essential tremor. (PubMed id 22863194)^{1, 2} Merner N.D.... Rouleau G.A. (2012)
Genetic contribution of FUS to frontotemporal lobar d egeneration. (PubMed id 20124201)^{1, 2} Van Langenhove T....Van Broeckhoven C. (2010)
Mutations of FUS gene in sporadic amyotrophic lateral sclerosis. (PubMed id 19861302)^{1, 2} Corrado L....Silani V. (2010)
TDRD3, a novel Tudor domain-containing protein, localizes to cytoplasmic stress granules. (PubMed id 18632687)^{1, 2} Goulet I.... Cote J. (2008)
Intracellular characterization of DDX39, a novel growth-associated RNA helicase. (PubMed id 17196963)^{1, 2} Sugiura T.... Nagano Y. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 2521	HGNC: 4010	AceView: FUS	Ensembl:ENSG00000089280	euGenes: HUgn2521
ECgene: FUS	H-InvDB: FUS

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for FUS	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for FUS	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for FUS gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for FUS gene:
Search GeneIP for patents involving FUS

GeneCards and IP:
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About This Section

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FUS (Gene Symbol)
Fused In Sarcoma
TLS
ALS6
FUS1
Oncogene FUS
Oncogene TLS
Translocated In Liposarcoma Protein
75 KDa DNA-Pairing Protein
Amyotrophic Lateral Sclerosis 6
Fusion (Involved In T(12;16) In Malignant Liposarcoma)
Fusion, Derived From T(12;16) Malignant Liposarcoma
HnRNP-P2
ETM4
HNRNPP2
POMP75
Fus-Like Protein
Fusion Gene In Myxoid Liposarcoma
Heterogeneous Nuclear Ribonucleoprotein P2
RNA-Binding Protein FUS
POMp75

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FUS Gene

fused in sarcoma

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