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Aliases for FUS Gene

Aliases for FUS Gene

  • FUS RNA Binding Protein 2 3
  • TLS 3 4 6
  • Heterogeneous Nuclear Ribonucleoprotein P2 2 3
  • Translocated In Liposarcoma Protein 3 4
  • 75 KDa DNA-Pairing Protein 3 4
  • Fused In Sarcoma 2 3
  • Oncogene FUS 3 4
  • Oncogene TLS 3 4
  • POMP75 3 4
  • ALS6 3 6
  • ETM4 3 6
  • Fusion (Involved In T(12;16) In Malignant Liposarcoma) 2
  • Fusion, Derived From T(12;16) Malignant Liposarcoma 2
  • Fusion Gene In Myxoid Liposarcoma 3
  • Amyotrophic Lateral Sclerosis 6 2
  • Translocated In Liposarcoma 2
  • RNA-Binding Protein FUS 3
  • Fus-Like Protein 3
  • HNRNPP2 3
  • FUS1 3

External Ids for FUS Gene

Previous Symbols for FUS Gene

  • ALS6

Summaries for FUS Gene

Entrez Gene Summary for FUS Gene

  • This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]

GeneCards Summary for FUS Gene

FUS (FUS RNA Binding Protein) is a Protein Coding gene. Diseases associated with FUS include tremor, hereditary essential, 4 and amyotrophic lateral sclerosis 6, autosomal recessive, with or without frontotemporal dementia. Among its related pathways are Translational Control and Transcriptional misregulation in cancer. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is EWSR1.

UniProtKB/Swiss-Prot for FUS Gene

  • Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity

Gene Wiki entry for FUS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUS Gene

Genomics for FUS Gene

Genomic Location for FUS Gene

Start:
31,180,110 bp from pter
End:
31,194,871 bp from pter
Size:
14,762 bases
Orientation:
Plus strand

Genomic View for FUS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUS Gene

Regulatory Elements for FUS Gene

Proteins for FUS Gene

  • Protein details for FUS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35637-FUS_HUMAN
    Recommended name:
    RNA-binding protein FUS
    Protein Accession:
    P35637
    Secondary Accessions:
    • Q9H4A8

    Protein attributes for FUS Gene

    Size:
    526 amino acids
    Molecular mass:
    53426 Da
    Quaternary structure:
    • Component of nuclear riboprotein complexes. Interacts with ILF3, TDRD3 and SF1. Interacts through its C-terminus with SFRS13A. Interacts with OTUB1 and SARNP.

    Three dimensional structures from OCA and Proteopedia for FUS Gene

    Alternative splice isoforms for FUS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUS Gene

Proteomics data for FUS Gene at MOPED

Post-translational modifications for FUS Gene

  • Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys316 and Lys365

Other Protein References for FUS Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for FUS Gene

Domains for FUS Gene

Gene Families for FUS Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Graphical View of Domain Structure for InterPro Entry

P35637

UniProtKB/Swiss-Prot:

FUS_HUMAN
Domain:
  • Contains 1 RRM (RNA recognition motif) domain.:
    • P35637
Family:
  • Belongs to the RRM TET family.:
    • P35637
Similarity:
  • Contains 1 RanBP2-type zinc finger.:
    • P35637
genes like me logo Genes that share domains with FUS: view

Function for FUS Gene

Molecular function for FUS Gene

GENATLAS Biochemistry: RNA binding protein,highly homologous to EWS1,glycine-rich,regulator of BCR/ABL-mediated leukemogenesis,rearranged in myxoid liposarcoma with translocation t(12;16) and in myeloid leukemia with translocation t(16;21)(q13;p11)
UniProtKB/Swiss-Prot Function: Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity

Gene Ontology (GO) - Molecular Function for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003677 DNA binding IEA --
GO:0003713 transcription coactivator activity IDA 21909421
GO:0003723 RNA binding TAS 8510758
genes like me logo Genes that share ontologies with FUS: view
genes like me logo Genes that share phenotypes with FUS: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for FUS Gene

Localization for FUS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUS Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUS Gene COMPARTMENTS Subcellular localization image for FUS gene
Compartment Confidence
nucleus 5
cytoskeleton 2
cytosol 2
chloroplast 1

Gene Ontology (GO) - Cellular Components for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16365397
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FUS: view

Pathways for FUS Gene

genes like me logo Genes that share pathways with FUS: view

Pathways by source for FUS Gene

2 Cell Signaling Technology pathways for FUS Gene
1 BioSystems pathway for FUS Gene

Gene Ontology (GO) - Biological Process for FUS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0008219 cell death --
GO:0008380 RNA splicing TAS --
GO:0010467 gene expression TAS --
GO:1903506 regulation of nucleic acid-templated transcription IDA 21909421
genes like me logo Genes that share ontologies with FUS: view

Compounds for FUS Gene

(2) Novoseek inferred chemical compound relationships for FUS Gene

Compound -log(P) Hits PubMed IDs
leucine 24.4 1
zinc 0 2
genes like me logo Genes that share compounds with FUS: view

Transcripts for FUS Gene

Unigene Clusters for FUS Gene

Fused in sarcoma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUS Gene

No ASD Table

Relevant External Links for FUS Gene

GeneLoc Exon Structure for
FUS
ECgene alternative splicing isoforms for
FUS

Expression for FUS Gene

mRNA expression in normal human tissues for FUS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUS Gene

SOURCE GeneReport for Unigene cluster for FUS Gene Hs.46894

mRNA Expression by UniProt/SwissProt for FUS Gene

P35637-FUS_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with FUS: view

No data available for mRNA differential expression in normal tissues for FUS Gene

Orthologs for FUS Gene

This gene was present in the common ancestor of animals.

Orthologs for FUS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUS 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUS 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUS 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fus 16
Fus 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUS 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUS 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUS 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia fus-prov 35
zebrafish
(Danio rerio)
Actinopterygii fus 36
  • 65 (a)
OneToOne
zgc56390 35
fruit fly
(Drosophila melanogaster)
Insecta caz 36
  • 42 (a)
ManyToMany
CG14718 36
  • 25 (a)
ManyToMany
Species with no ortholog for FUS:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUS Gene

ENSEMBL:
Gene Tree for FUS (if available)
TreeFam:
Gene Tree for FUS (if available)

Paralogs for FUS Gene

Paralogs for FUS Gene

Selected SIMAP similar genes for FUS Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FUS: view

Variants for FUS Gene

Sequence variations from dbSNP and Humsavar for FUS Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs10684 -- 31,191,077(+) GGACA(A/G)AGGTG missense, reference, nc-transcript-variant
rs741810 -- 31,182,621(+) TCAGG(A/C)TATGG synonymous-codon, reference, nc-transcript-variant, utr-variant-5-prime
rs760184 -- 31,182,395(+) TTTTG(C/G)AGATT intron-variant
rs760185 -- 31,183,158(+) gagga(A/G)gctga intron-variant
rs929867 -- 31,180,161(-) CTGAG(C/T)ACCGA utr-variant-5-prime, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for FUS Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
nsv457483 CNV Loss 19166990
dgv2672n71 CNV Loss 21882294

Relevant External Links for FUS Gene

HapMap Linkage Disequilibrium report
FUS
Human Gene Mutation Database (HGMD)
FUS
Locus Specific Mutation Databases (LSDB)
FUS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUS Gene

Disorders for FUS Gene

(2) OMIM Diseases for FUS Gene (137070)

UniProtKB/Swiss-Prot

FUS_HUMAN
  • Note=A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3.
  • Note=A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG.
  • Angiomatoid fibrous histiocytoma (AFH) [MIM:612160]: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein.
  • Amyotrophic lateral sclerosis 6 (ALS6) [MIM:608030]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269 PubMed:19251627, ECO:0000269 PubMed:19251628, ECO:0000269 PubMed:19861302, ECO:0000269 PubMed:20124201}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Tremor, hereditary essential 4 (ETM4) [MIM:614782]: A common movement disorder mainly characterized by postural tremor of the arms. Head, legs, trunk, voice, jaw, and facial muscles also may be involved. The condition can be aggravated by emotions, hunger, fatigue and temperature extremes, and may cause a functional disability or even incapacitation. Inheritance is autosomal dominant. {ECO:0000269 PubMed:22863194}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(12) Novoseek inferred disease relationships for FUS Gene

Disease -log(P) Hits PubMed IDs
liposarcoma myxoid 95 14
liposarcoma 87.6 15
sarcoma clear cell 61.6 2
sarcoma 60.9 9
ewings sarcoma 59 3

Genatlas disease for FUS Gene

myxoid and round cell subtype liposarcoma,with breakpoint in t(12;16)(q13;p11) translocation

Relevant External Links for FUS

GeneTests
FUS
GeneReviews
FUS
Genetic Association Database (GAD)
FUS
Human Genome Epidemiology (HuGE) Navigator
FUS
genes like me logo Genes that share disorders with FUS: view

Publications for FUS Gene

  1. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. (PMID: 7503811) Rabbitts T.H. … Nathan P. (Nat. Genet. 1993) 2 3 4 23
  2. Human POMp75 is identified as the pro-oncoprotein TLF/FUS: both POMp75 and POMp100 DNA homologous pairing activities are associated to cell proliferation. (PMID: 10442642) Bertrand P. … Lopez B.S. (Oncogene 1999) 3 4 23
  3. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. (PMID: 19251627) Kwiatkowski T.J. Jr. … Brown R.H. Jr. (Science 2009) 2 3 4
  4. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. (PMID: 19251628) Vance C. … Shaw C.E. (Science 2009) 2 3 4
  5. Ebp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity. (PMID: 19946338) Oh S.M. … Ye K. (Oncogene 2010) 3 23

Products for FUS Gene

  • Addgene plasmids for FUS

Sources for FUS Gene

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