Aliases for FUS Gene
External Ids for FUS Gene
Previous HGNC Symbols for FUS Gene
Previous GeneCards Identifiers for FUS Gene
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6. [provided by RefSeq, Sep 2009]
GeneCards Summary for FUS Gene
FUS (FUS RNA Binding Protein) is a Protein Coding gene. Diseases associated with FUS include tremor, hereditary essential, 4 and amyotrophic lateral sclerosis 6, with or without frontotemporal dementia. Among its related pathways are Gene Expression and mRNA Splicing - Major Pathway. GO annotations related to this gene include nucleic acid binding and identical protein binding. An important paralog of this gene is EWSR1.
UniProtKB/Swiss-Prot for FUS Gene
Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.