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FURIN Gene

protein-coding   GIFtS: 73
GCID: GC15P091411

Furin (Paired Basic Amino Acid Cleaving Enzyme)

(Previous names: paired basic amino acid cleaving enzyme (furin, membrane...)
(Previous symbols: PCSK3, FUR, PACE)
  See FURIN-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Furin (Paired Basic Amino Acid Cleaving Enzyme)1 2     Dibasic Processing Enzyme2
FUR1 2 3 5     FES Upstream Region2
PACE1 2 3 5     furin2
PCSK31 2 3 5     Furin, Membrane Associated Receptor Protein2
Paired Basic Amino Acid Residue-Cleaving Enzyme2 3     Proprotein Convertase Subtilisin/Kexin Type 32
EC 3.4.21.753 8     Dibasic-Processing Enzyme3
Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated
Receptor Protein)1
     EC 3.4.218
SPC12     

External Ids:    HGNC: 85681   Entrez Gene: 50452   Ensembl: ENSG000001405647   OMIM: 1369505   UniProtKB: P099583   

Export aliases for FURIN gene to outside databases

Previous GC identifers: GC15P084851 GC15P088999 GC15P089141 GC15P089212 GC15P067523


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FURIN Gene:
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that
process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory
pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine,
liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then
sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the
catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members
which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid
hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix
metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be
one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a
role in tumor progression. This gene is located in close proximity to family member proprotein convertase
subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Jan 2014)

GeneCards Summary for FURIN Gene:
FURIN (furin (paired basic amino acid cleaving enzyme)) is a protein-coding gene. Diseases associated with FURIN include plague, and parainfluenza virus type 3. GO annotations related to this gene include peptidase activity and serine-type endopeptidase activity. An important paralog of this gene is PCSK2.

UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958
Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways
and capable of cleavage at the RX(K/R)R consensus motif

Gene Wiki entry for FURIN (Furin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FURIN gene promoter:
         TBP   AP-1   ATF-2   c-Jun   GATA-1   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFURIN promoter sequence
   Search Chromatin IP Primers for FURIN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FURIN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

FURIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FURIN gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P091411:  view genomic region     (about GC identifiers)

Start:
91,411,822 bp from pter      End:
91,426,688 bp from pter
Size:
14,867 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958 (See protein sequence)
Recommended Name: Furin precursor  
Size: 794 amino acids; 86678 Da
Cofactor: Calcium
Subunit: Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to
clathrin adapters
Secondary accessions: Q14336 Q6LBS3 Q9UCZ5

Explore the universe of human proteins at neXtProt for FURIN: NX_P09958

Explore proteomics data for FURIN at MOPED

Post-translational modifications: 

  • The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the
    endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following
    transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide
    dissociation and furin activation1
  • Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and
    non-phosphorylated forms1
  • Ubiquitination2 at Lys748
  • Glycosylation2 at Asn387, Asn440, Asn553
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FURIN (P09958) (see all 26)
     NNYGTLT  DGYTNSI  WASGNGG  EPKDIGK 


    See FURIN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001276752.1  NP_001276753.1  NP_002560.1  

    ENSEMBL proteins: 
     ENSP00000268171   ENSP00000452730   ENSP00000453212   ENSP00000453942  
    Reactome Protein details: P09958

    FURIN Human Recombinant Protein Products:

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    Novus Biologicals FURIN Protein
    Novus Biologicals FURIN Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for FURIN
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FURIN 

     
    antibodies-online proteins for FURIN (15 products) 

     
    antibodies-online peptides for FURIN

    FURIN Antibody Products:

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    antibodies-online antibodies for FURIN (48 products) 

    FURIN Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for FURIN 
    antibodies-online kits for FURIN (16 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 10):
     IPR006212 Furin_repeat
     IPR000209 Peptidase_S8/S53_dom
     IPR015500 Peptidase_S8_subtilisin-rel
     IPR022398 Peptidase_S8_His-AS
     IPR008979 Galactose-bd-like

    Graphical View of Domain Structure for InterPro Entry P09958

    ProtoNet protein and cluster: P09958

    3 Blocks protein domains:
    IPB000209 Subtilisin serine protease family (S8) signature
    IPB002884 Proprotein convertase
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958
    Domain: Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface
    Similarity: Belongs to the peptidase S8 family. Furin subfamily
    Similarity: Contains 1 homo B/P domain


    Find genes that share domains with FURIN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FURIN_HUMAN, P09958
    Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways
    and capable of cleavage at the RX(K/R)R consensus motif
    Catalytic activity: Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg- -Zaa-
    bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and vWF
    from their respective precursors
    Enzyme regulation: Could be inhibited by the not secondly cleaved propeptide

         Enzyme Numbers (IUBMB): EC 3.4.21.751 2 EC 3.4.212

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI14744861
    GO:0004175endopeptidase activity IDA17010968
    GO:0004252serine-type endopeptidase activity IDA10567353
    GO:0004867serine-type endopeptidase inhibitor activity IDA10567353
    GO:0005515protein binding ----
         
    Find genes that share ontologies with FURIN           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for FURIN:
     Increased viability after born  Synthetic lethal with gemcitab  Upregulation of Wnt/beta-caten 

         10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Furin):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size/body  hematopoietic system 
     immune system  liver/biliary system  mortality/aging  nervous system  normal 

    Find genes that share phenotypes with FURIN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FURIN: Furintm1.1Jwmc Furintm1Ajmr

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for FURIN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for FURIN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for FURIN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for FURIN

    miRNA
    Products:
        
    miRTarBase miRNAs that target FURIN:
    hsa-mir-16-5p (MIRT031785), hsa-mir-615-3p (MIRT039979), hsa-mir-103a-3p (MIRT027060), hsa-mir-24-3p (MIRT005919), hsa-mir-484 (MIRT042240)

    Block miRNA regulation of human, mouse, rat FURIN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate FURIN (see all 76):
    hsa-miR-1914* hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-219-5p hsa-miR-371-5p hsa-miR-93 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidFURIN 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat FURIN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for FURIN

    Clone
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    OriGene clones in human, mouse for FURIN (see all 7)
    OriGene ORF clones in mouse, rat for FURIN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: FURIN (NM_002569)
    Sino Biological Human cDNA Clone for FURIN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for FURIN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FURIN

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FURIN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FURIN_HUMAN, P09958: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell
    membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell
    surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER).
    A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the
    propeptide and the activation of furin
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    plasma membrane5
    cytosol2
    endoplasmic reticulum2
    endosome2
    extracellular2
    chloroplast1
    cytoskeleton1
    lysosome1
    nucleus1
    peroxisome1
    vacuole1

    Gene Ontology (GO): Selected cellular component terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane TAS--
    GO:0005615NOT extracellular space IDA10567353
    GO:0005796Golgi lumen TAS--
    GO:0005802trans-Golgi network IDA14744861
    GO:0005886plasma membrane TAS--

    Find genes that share ontologies with FURIN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FURIN About   (see all 25)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2HIV Life Cycle
    HIV Life Cycle0.91
    HIV Infection0.62
    Late Phase of HIV Life Cycle0.91
    Assembly Of The HIV Virion0.00
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    Collagen degradation0.43
    4PTM- gamma carboxylation, hypusine formation and arylsulfatase activation
    PTM- gamma carboxylation, hypusine formation and arylsulfatase activation0.31
    Removal of aminoterminal propeptides from gamma-carboxylated proteins0.00
    Gamma-carboxylation, transport, and amino-terminal cleavage of proteins0.00
    5Signaling by FGFR
    Signaling by PDGF0.87
    Signalling by NGF0.71


    Find genes that share SuperPaths with FURIN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for FURIN
        Notch Signaling Pathways


    2 GeneGo (Thomson Reuters) Pathways for FURIN
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
    Development Notch Signaling Pathway

    5 BioSystems Pathways for FURIN
        Delta-Notch Signaling Pathway
    p75(NTR)-mediated signaling
    Glypican 3 network
    HIF-1-alpha transcription factor network
    Notch signaling pathway


    Selected Reactome Pathways for FURIN (see all 10)
        NGF processing
    TGF-beta receptor signaling activates SMADs
    Elastic fibre formation
    Removal of aminoterminal propeptides from gamma-carboxylated proteins
    Synthesis and processing of ENV and VPU


    1 Kegg Pathway  (Kegg details for FURIN):
        Influenza A

        Pathway & Disease-focused RT2 Profiler PCR Array including FURIN: 
              TGFB Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for FURIN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FURIN (P099582, 3 ENSP000002681714) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MMP14P502812, 3, ENSP000003082084MINT-7898002 I2D: score=1 STRING: ENSP00000308208
    TGOLN2O434932, 3, ENSP000003666034MINT-3372400 I2D: score=1 STRING: ENSP00000366603
    GORASP2Q9H8Y82, 3, ENSP000002341604MINT-7897990 I2D: score=1 STRING: ENSP00000234160
    ADAMTS4O751733, ENSP000003569754I2D: score=2 STRING: ENSP00000356975
    LRP1Q079543, ENSP000002430774I2D: score=2 STRING: ENSP00000243077
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006465signal peptide processing IDA16912035
    GO:0006508proteolysis TAS--
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0007219Notch signaling pathway TAS--
    GO:0008283cell proliferation IMP15899807

    Find genes that share ontologies with FURIN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Enzo Life Sciences drugs & compounds for FURIN
      Browse compounds at ApexBio 

    Browse Tocris compounds for FURIN

    1 HMDB Compound for FURIN    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for FURIN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Decanoic Acid-- 334-48-5target--10592235

    Selected Novoseek inferred chemical compound relationships for FURIN gene (see all 47)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dfurin2 84.5 3 1512259 (2)
    arg-arg 69.6 1 8846780 (1)
    exotoxin-a 67.4 10 9169757 (3), 7989356 (2), 9636142 (1), 10600112 (1) (see all 5)
    serine 67.3 52 9598975 (2), 1644824 (2), 8218226 (2), 1325651 (2) (see all 42)
    prosomatostatin 59.1 3 7619075 (2), 8095501 (1)
    peptidylglycine 53.6 2 7865135 (1), 8402152 (1)
    mannose 6-phosphate 48.7 5 10547356 (1), 11331585 (1), 11014362 (1), 9695949 (1) (see all 5)
    preproinsulin 45.9 2 15821105 (1), 11874714 (1)
    tgf beta1 42.1 10 11424093 (2), 14644155 (2), 11014362 (2), 10099264 (1) (see all 6)
    proglucagon 41.7 3 15528303 (1), 12651102 (1)



    Find genes that share compounds with FURIN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FURIN gene (3 alternative transcripts): 
    NM_001289823.1  NM_001289824.1  NM_002569.3  

    Unigene Cluster for FURIN:

    Furin (paired basic amino acid cleaving enzyme)
    Hs.513153  [show with all ESTs]
    Unigene Representative Sequence: NM_002569
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000268171(uc002bpu.1) ENST00000559353 ENST00000560824 ENST00000558794
    ENST00000560018
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate FURIN (see all 76):
    hsa-miR-1914* hsa-miR-15a hsa-miR-106a hsa-miR-128 hsa-miR-219-5p hsa-miR-371-5p hsa-miR-93 hsa-miR-3116
    SwitchGear 3'UTR luciferase reporter plasmidFURIN 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: FURIN (NM_002569)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FURIN
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FURIN
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      QuantiTect SYBR Green Assays in human, mouse, rat FURIN
      QuantiFast Probe-based Assays in human, mouse, rat FURIN

    Additional mRNA sequence: 

    AL110107.1 BC008295.1 BC012181.1 S65442.1 X17094.1 

    9 DOTS entries:

    DT.447619  DT.100733268  DT.91774265  DT.121062643  DT.97796995  DT.100786346  DT.121062677  DT.95246561 
    DT.95246560 

    Selected AceView cDNA sequences (see all 296):

    AI633315 BF196808 BU541301 BC012181 BU542206 AW403605 AA325040 AW405830 
    BU625529 BQ669905 BM311681 BQ934799 BM311086 AI222953 BQ684738 X17094 
    BM917196 CK819816 BE219000 BQ880122 AW467853 NM_002569 BQ889060 BC008295 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FURIN    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                                                                            


    ECgene alternative splicing isoforms for FURIN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FURIN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGATAATGTT
    FURIN Expression
    About this image


    FURIN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Hypoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Hypoblast Cells Hypoblast
             Extraembryonic Visceral Endoderm
     
     Epithelial Cells
             Corneocytes Stratified Epidermis
     
     Primitive Streak (Early Embryonic Tissues)
             Notochordal Plate
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Uncategorized
             Extra-embryonic endoderm cells
    FURIN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FURIN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513153

    UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958
    Tissue specificity: Seems to be expressed ubiquitously

        Pathway & Disease-focused RT2 Profiler PCR Array including FURIN: 
              TGFB Signaling Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FURIN gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Furin1 , 5 furin (paired basic amino acid cleaving enzyme)1, 5 88.52(n)1
    93.95(a)1
      7 (45.65 cM)5
    185501  NM_001081454.11  NP_001074923.11 
     803885855 
    chicken
    (Gallus gallus)
    Aves FURIN1 furin (paired basic amino acid cleaving enzyme) 77.58(n)
    80.82(a)
      395457  NM_204715.1  NP_990046.1 
    lizard
    (Anolis carolinensis)
    Reptilia FURIN6
    furin (paired basic amino acid cleaving enzyme)
    69(a)
    1 ↔ 1
    GL343759.1(131782-161032)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3977472 furin 76.76(n)    M80471.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BI841416.12   -- 82.14(n)    BI841416.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0013301 AgaP_AGAP001330 60.01(n)
    60.8(a)
      1281848  XM_321814.4  XP_321814.4 
    worm
    (Caenorhabditis elegans)
    Secernentea kpc-11 kpc-1 56.61(n)
    61.06(a)
      173051  NM_060573.5  NP_492974.2 


    ENSEMBL Gene Tree for FURIN (if available)
    TreeFam Gene Tree for FURIN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FURIN gene
    PCSK22  PCSK42  PCSK62  PCSK12  PCSK72  PCSK52  
    6 SIMAP similar genes for FURIN using alignment to 4 protein entries:     FURIN_HUMAN (see all proteins):
    PCSK5    PCSK6    PCSK2    PCSK4    PCSK1    PCSK7

    Find genes that share paralogs with FURIN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FURIN (see all 436)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs797420141,2
    F--91409905(+) CTCTCC/TGGGCC 1 -- us2k11Minor allele frequency- T:0.01NA 120
    rs37599291,2
    C,F,H--91410009(-) ACAAAC/AAGAAG 1 -- us2k1 tfbs326Minor allele frequency- A:0.39EA NS NA WA CSA 3847
    rs1384974071,2
    C--91410166(+) GAGGTA/GTAACT 1 -- us2k10--------
    rs1893325361,2
    --91410176(+) TGACAC/TACTAT 1 -- us2k10--------
    rs1414209701,2
    C--91410187(+) AAACGA/GCATGG 1 -- us2k10--------
    rs1502548631,2
    C--91410337(+) GATCTC/GTTTTC 1 -- us2k10--------
    rs734895451,2
    C,F--91410349(+) AAATAC/TGTCTT 1 -- us2k12Minor allele frequency- T:0.08WA 120
    rs1167855871,2
    C,F--91410592(+) AGTTCC/TCAGCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs559082051,2
    C--91410597(+) CCAGCA/GGACAA 1 -- us2k10--------
    rs1493835371,2
    --91410615(+) TGCCTC/TGAACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for FURIN (91411822 - 91426688 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for FURIN:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833089CNV Loss17160897
    esv22296CNV Loss19812545
    nsv515661CNV Loss19592680
    dgv2436n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): FURIN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FURIN
    DNA2.0 Custom Variant and Variant Library Synthesis for FURIN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136950    OMIM disorders: --

    6 diseases for FURIN:    
    About MalaCards
    plague    parainfluenza virus type 3    avian influenza    hypohidrotic ectodermal dysplasia
    venezuelan equine encephalitis    influenza

    5 diseases from the University of Copenhagen DISEASES database for FURIN:
    Influenza     Netherton syndrome     Vaccinia     Venezuelan equine encephalitis
    Diphtheria

    Find genes that share disorders with FURIN           About GenesLikeMe

    Selected Novoseek inferred disease relationships for FURIN gene (see all 38)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dementia, familial british 81.4 2 10526337 (1), 12883829 (1)
    anthrax 71 27 1644824 (2), 16041026 (2), 18977558 (2), 14688144 (2) (see all 15)
    amyloidosis familial 70.8 3 14596804 (1), 14675544 (1), 11707399 (1)
    fowl plague 45.8 2 1360148 (1), 1628614 (1)
    colon carcinoma 44.9 15 7690548 (2), 12691605 (1), 12782675 (1), 7707552 (1) (see all 9)
    ectodermal dysplasia, hypohidrotic 38.1 1 11416205 (1)
    influenza 34.3 12 8057485 (3), 10074171 (1), 7562936 (1), 10219565 (1) (see all 10)
    diphtheria 27.4 3 18089813 (1), 8253774 (1)
    colon adenocarcinoma 26.7 4 12736257 (1), 8760366 (1), 12058031 (1), 8057485 (1)
    immunodeficiency 26.2 14 8189547 (2), 8325837 (1), 8163529 (1), 10567353 (1) (see all 13)

    Genetic Association Database (GAD): FURIN
    Human Genome Epidemiology (HuGE) Navigator: FURIN (7 documents)

    Export disorders for FURIN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FURIN gene, integrated from 10 sources (see all 488):
    (articles sorted by number of sources associating them with FURIN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. (PubMed id 2251280)1, 2, 3 Wise R.J....Kaufman R.J. (Proc. Natl. Acad. Sci. U.S.A. 1990)
    2. Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. (PubMed id 1629222)1, 2, 9 Leduc R.... Thomas G. (J. Biol. Chem. 1992)
    3. Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. (PubMed id 8846780)1, 2, 9 Jones B.G....Thomas G. (EMBO J. 1995)
    4. A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. (PubMed id 7690548)1, 2, 9 Takahashi S.... Nakayama K. (Biochem. Biophys. Res. Commun. 1993)
    5. PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic. (PubMed id 11331585)1, 2, 9 Crump C.M....Thomas G. (EMBO J. 2001)
    6. Associations between genetic variations in the FURIN gene and hypertension. (PubMed id 20707915)1, 4 Li N....Chang J. (BMC Med. Genet. 2010)
    7. Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression. (PubMed id 19998449)1, 4 FAPrsti A....Lenner P. (amp 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Influence of a single nucleotide polymorphism in the P1 promoter of the furin gene on transcription activity and hepatitis B virus infection. (PubMed id 19492430)1, 4 Lei R.X....Chen G.H. (Hepatology 2009)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5045 HGNC: 8568 AceView: FURIN Ensembl:ENSG00000140564 euGenes: HUgn5045
    ECgene: FURIN Kegg: 5045 H-InvDB: FURIN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FURIN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for FURIN Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FURIN gene:
    Search GeneIP for patents involving FURIN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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