FURIN Gene
protein-coding GIFtS : 73 GCID: GC15 P091411
furin (paired basic amino acid cleaving enzyme) paired basic amino acid cleaving enzyme (furin, membrane... PCSK3, FUR, PACE )
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Aliasesfor FURIN gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Furin (Paired Basic Amino Acid Cleaving Enzyme) 1 2 Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated ReceptorProtein)1 FUR1 2 3 5 Dibasic Processing Enzyme2 PACE1 2 3 5 FES Upstream Region2 PCSK31 2 3 5 Furin1 SPC11 2 Furin, Membrane Associated Receptor Protein2 Dibasic-Processing Enzyme2 3 Proprotein Convertase Subtilisin/Kexin Type 32 Paired Basic Amino Acid Residue-Cleaving Enzyme2 3 EC 3.4.218 EC 3.4.21.753 8
Export aliases for FURIN gene to outside databases Previous GC identifers: GC15P084851 GC15P088999 GC15P089141 GC15P089212 GC15P067523
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Summariesfor FURIN gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for FURIN : The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene is thought to play a role in tumor progression. The use of alternate polyadenylation sites has been found for this gene. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958 Function : Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways andcapable of cleavage at the RX(K/R)R consensus motif Gene Wiki entry for FURIN (Furin)
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Genomic Viewsfor FURIN gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010274.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FURIN gene promoter:TBP AP-1 ATF-2 c-Jun GATA-1 YY1 Other transcription factors Search SABiosciences Chromatin IP Primers for FURIN Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q26.1 Ensembl cytogenetic band: 15q26.1 HGNC cytogenetic band: 15q26.1 FURIN Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P091411: view genomic region
(about GC identifiers )
Start: 91,411,822 bp from pter End:
91,426,688 bp from pter
Size: 14,867 bases Orientation:
plus strand
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Proteinsfor FURIN gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958 See
protein sequence )Recommended Name: Size : 794 amino acids; 86678 DaCofactor : CalciumSubunit : Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrinadapters
Subcellular location : Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cellmembrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin
Secondary accessions : Q14336 Q6LBS3 Q9UCZ5Explore the universe of human proteins at neXtProt for FURIN: NX_P09958 Post-translational modifications:
The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation1
Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P09958 4/26 DME Specific Peptides for FURIN (P09958 ) (see all 26 )FURIN Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_002560.1 ENSEMBL proteins: ENSP00000268171 ENSP00000452730 ENSP00000453212 ENSP00000453942 Reactome Protein details: P09958 Human Recombinant Protein Products for FURIN: Gene Ontology (GO): 5/11 cellular component terms (GO ID links to tree view) (see all 11 ): About this table
About GeneDecksing FURIN Antibody Products: Assay Products for FURIN:
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Protein
Domains /for FURIN gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/10 InterPro domains/families (see all 10 ):
Graphical View of Domain Structure for InterPro Entry P09958 ProtoNet protein and cluster: P09958
3 Blocks protein families : IPB000209 IPB002884 IPB006212 UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958 Domain : Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surfaceSimilarity : Belongs to the peptidase S8 family. Furin subfamilySimilarity : Contains 1 homo B/P domain
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Functionfor FURIN gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: FURIN_HUMAN, P09958 Function : Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways andcapable of cleavage at the RX(K/R)R consensus motif Catalytic activity : Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg- -Zaa- bonds,where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and vWF from their respective precursors Enzyme regulation : Could be inhibited by the not secondly cleaved propeptide Enzyme Numbers (IUBMB): EC 3.4.21.75 1 2 EC 3.4.21 2
Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9 ): About this table
About GeneDecksing Phenotypes: 3 GenomeRNAi human phenotypes for FURIN :7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Furin) :About GeneDecksing Animal Models: Furin tm1.1Jwmc Furin tm1Ajmr Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FURIN (NM_002569 ) Sino Biological Human cDNA Clone for FURIN DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FURIN Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FURIN
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FURIN
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Pathways & Interactionsfor FURIN gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/24 super-pathways (see all 24 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Degradation of the extracellular matrix 2 Development_Notch Signaling Pathway 3 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins 4 Pre-NOTCH Processing in Golgi 5 Signaling by FGFR
Pathway sources See GeneCards unified pathways Show all pathways 1 2 5 5/22 (see all 22 )1 (Kegg details for FURIN) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FURIN STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/66 Interacting proteins for FURIN (P09958 2 , 3 ENSP00000268171 4 via UniProtKB, MINT, STRING , and/or I2D (see all 66 )About this table Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28 ): About this table
About GeneDecksing
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Drugs & Compoundsfor FURIN gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Enzo Life Sciences drugs & compounds for FURIN
Browse Tocris compounds for FURIN 1 HMDB Compound for FURIN About this table 1 DrugBank Compound for FURIN About this table 10/47 Novoseek chemical compound relationships for FURIN gene (see all 47 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
dfurin2
84.5
3
1512259 (2)
arg-arg
69.6
1
8846780 (1)
exotoxin-a
67.4
10
9169757 (3), 7989356 (2), 9636142 (1), 10600112 (1) (see all 5 )
serine
67.3
52
9598975 (2), 1644824 (2), 8218226 (2), 1325651 (2) (see all 42 )
prosomatostatin
59.1
3
7619075 (2), 8095501 (1)
peptidylglycine
53.6
2
7865135 (1), 8402152 (1)
mannose 6-phosphate
48.7
5
10547356 (1), 11331585 (1), 11014362 (1), 9695949 (1) (see all 5 )
preproinsulin
45.9
2
15821105 (1), 11874714 (1)
tgf beta1
42.1
10
11424093 (2), 14644155 (2), 11014362 (2), 10099264 (1) (see all 6 )
proglucagon
41.7
3
15528303 (1), 12651102 (1)
FURIN
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Transcriptsfor FURIN gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for FURIN gene: NM_002569.2 Unigene Cluster for FURIN:
Furin (paired basic amino acid cleaving enzyme) Hs.513153 [show with all ESTs ] Unigene Representative Sequence: NM_002569 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000268171 (uc002bpu.1 ) ENST00000559353 ENST00000560824 ENST00000558794 ENST00000560018 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 3 )human mouse rat OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: FURIN (NM_002569 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FURIN Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FURIN
Additional cDNA sequence: AL110107.1 BC008295.1 BC012181.1 S65442.1 X17094.1
10 DOTS entries : DT.447619 DT.100733268
DT.91774265 DT.121062643 DT.97796995 DT.100786346 DT.121062677 DT.95246561 DT.95246560 DT.97863702 24/296 AceView cDNA sequences (see all 296 ):
BC008295 BQ636937 AW405830 AI633315 AI222953 AA325040 AL121024 NM_002569 BQ690452 BQ684738 X17094 F06207 BU625529 BM830768 BU191560 BU542206 BM917196 BQ669905 BQ889060 BQ934799 BM311681 CK819816 BE219000 BQ880122 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for FURIN About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 SP1 : SP2 : SP3 :
ECgene alternative splicing isoforms for FURIN
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Expression for FURIN gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section FURIN expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGATAATGTTAbout this image FURIN expression in embryonic tissues and stem cells About this table
See FURIN Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FURIN SOURCE GeneReport for Unigene cluster: Hs.513153 UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958 Tissue specificity : Seems to be expressed ubiquitouslySABiosciences Expression via Pathway-Focused PCR Array including FURIN : Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FURIN
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Orthologsfor FURIN gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for FURIN gene from 6/23 species (see all 23 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves FURIN1
furin (paired basic amino acid cleaving enzyme)
77.66(n) 80.82(a)
395457 NM_204715.1 NP_990046.1
lizard Reptilia FURIN6
--
77(a)
1 ↔ 1
GL343759.1(131782-160747)
African clawed frog Amphibia LOC3977472
furin
76.76(n)
M80471.1
zebrafish Actinopterygii BI841416.12
--
82.14(n)
BI841416.1
fruit fly Insecta Fur16
Furin 1
27(a)
1 → many
3R(21173090-21298778)
worm Secernentea kpc-11
Protein KPC-1
56.61(n) 61.06(a)
173051 NM_060573.4 NP_492974.2
ENSEMBL Gene Tree for FURIN (if available)TreeFam Gene Tree for FURIN (if available)
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Paralogsfor FURIN gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for FURIN gene PCSK2 2 PCSK4 2 PCSK6 2 PCSK1 2 PCSK7 2 PCSK5 2 6 SIMAP similar genes for FURIN using alignment to 4 protein entries: FURIN_HUMAN (see all proteins ):PCSK5 PCSK6 PCSK2 PCSK4 PCSK1 PCSK7 About GeneDecksing
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Genomic Variantsfor FURIN gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 15 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for FURIN (91411822 - 91426688 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for FURIN 2 CNVs 72354 49620 Human Gene Mutation Database (HGMD) : FURIN SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor FURIN gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 136950
OMIM disorders : --20/46 (see all 46 ): About MalaCards dementia familial british venezuelan equine encephalitis hypohidrotic ectodermal dysplasia parainfluenza virus type 3 ectodermal dysplasia avian influenza plague malignant glioma netherton syndrome amyloidosis cystic fibrosis borna disease diphtheria chikungunya insulinoma colon adenocarcinoma dementia influenza squamous cell carcinoma colon carcinoma 5 diseases from the University of Copenhagen DISEASES database for FURIN :Influenza Netherton syndrome Vaccinia Diphtheria Venezuelan equine encephalitis 10/38 Novoseek disease relationships for FURIN gene (see all 38 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
dementia, familial british
81.4
2
10526337 (1), 12883829 (1)
anthrax
71
27
1644824 (2), 16041026 (2), 18977558 (2), 14688144 (2) (see all 15 )
amyloidosis familial
70.8
3
14596804 (1), 14675544 (1), 11707399 (1)
fowl plague
45.8
2
1360148 (1), 1628614 (1)
colon carcinoma
44.9
15
7690548 (2), 12691605 (1), 12782675 (1), 7707552 (1) (see all 9 )
ectodermal dysplasia, hypohidrotic
38.1
1
11416205 (1)
influenza
34.3
12
8057485 (3), 10074171 (1), 7562936 (1), 10219565 (1) (see all 10 )
diphtheria
27.4
3
18089813 (1), 8253774 (1)
colon adenocarcinoma
26.7
4
12736257 (1), 8760366 (1), 12058031 (1), 8057485 (1)
immunodeficiency
26.2
14
8189547 (2), 8325837 (1), 8163529 (1), 10567353 (1) (see all 13 )
Genetic Association Database (GAD): FURIN Human Genome Epidemiology (HuGE) Navigator: FURIN (7 documents) Export disorders for FURIN gene to outside databases
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Publicationsfor FURIN gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for FURIN gene, integrated from 9 sources (see all 469 ):(articles sorted by number of sources associating them with FURIN) Utopia : connect your pdf to the dynamic
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. (PubMed id 2251280) 1 , 2 , 3(1990) Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. (PubMed id 1629222) 1 , 2 , 9(1992) Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. (PubMed id 8846780) 1 , 2 , 9(1995) A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. (PubMed id 7690548) 1 , 2 , 9(1993) PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic. (PubMed id 11331585) 1 , 2 , 9(2001) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) Homology modelling of the catalytic domain of human furin. A model for the eukaryotic subtilisin-like proprotein convertases. (PubMed id 8020465) 1 , 2 (1994) cDNA and gene structure for a human subtilisin-like protease with cleavage specificity for paired basic amino acid residues. (PubMed id 1713771) 1 , 2 (1991) Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. (PubMed id 1741956) 1 , 3(1991) Structural homology between the human fur gene product and the subtilisin-like protease encoded by yeast KEX2. (PubMed id 2408021) 1 , 2 (1990)
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About This Section Patent Information for FURIN gene: FURIN GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor FURIN gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for FURIN OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for FURIN Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for FURIN OriGene 3'-UTR Clone for FURIN OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for FURIN OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for FURIN OriGene Custom Protein Services for FURIN OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FURIN QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FURIN
ThermoFisher Antibody for FURIN
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat FURIN
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Expression by the Database of Embryonic development, Stem cell research, and
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