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Aliases for FURIN Gene

Aliases for FURIN Gene

  • Furin, Paired Basic Amino Acid Cleaving Enzyme 2 3 5
  • Paired Basic Amino Acid Residue-Cleaving Enzyme 3 4
  • EC 3.4.21.75 4 61
  • PCSK3 3 4
  • PACE 3 4
  • FUR 3 4
  • Paired Basic Amino Acid Cleaving Enzyme (Furin, Membrane Associated Receptor Protein) 2
  • Furin (Paired Basic Amino Acid Cleaving Enzyme) 2
  • Proprotein Convertase Subtilisin/Kexin Type 3 3
  • Furin, Membrane Associated Receptor Protein 3
  • Dibasic Processing Enzyme 3
  • Dibasic-Processing Enzyme 4
  • FES Upstream Region 3
  • EC 3.4.21 61
  • Furin 3
  • SPC1 3

External Ids for FURIN Gene

Previous HGNC Symbols for FURIN Gene

  • PCSK3
  • FUR
  • PACE

Previous GeneCards Identifiers for FURIN Gene

  • GC15P084851
  • GC15P088999
  • GC15P089141
  • GC15P089212
  • GC15P091411
  • GC15P067523

Summaries for FURIN Gene

Entrez Gene Summary for FURIN Gene

  • This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. The product of this gene is one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140 and may play a role in tumor progression. This gene is located in close proximity to family member proprotein convertase subtilisin/kexin type 6 and upstream of the FES oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for FURIN Gene

FURIN (Furin, Paired Basic Amino Acid Cleaving Enzyme) is a Protein Coding gene. Diseases associated with FURIN include Avian Influenza and Dementia, Familial British. Among its related pathways are RET signaling and Metabolism. GO annotations related to this gene include serine-type endopeptidase activity and serine-type endopeptidase inhibitor activity. An important paralog of this gene is PCSK4.

UniProtKB/Swiss-Prot for FURIN Gene

  • Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Gene Wiki entry for FURIN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FURIN Gene

Genomics for FURIN Gene

Regulatory Elements for FURIN Gene

Enhancers for FURIN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F090835 1.7 FANTOM5 Ensembl ENCODE 13.8 -29.5 -29524 7.3 ATF1 ARNT YY1 GTF3C2 GLIS2 ELK1 GATA2 FOS NCOA1 REST FES BLM FURIN LOC101926911 LOC100631255 UNC45A MAN2A2 HDDC3 ENSG00000200677 ENSG00000259314
GH15F090829 1.3 FANTOM5 Ensembl ENCODE 12.5 -38.0 -38045 2.7 HDGF BCOR MTA2 ZMYM3 CEBPB REST RELA SP1 ZNF316 EED FES UNC45A FURIN LOC101926911 HDDC3 ENSG00000200677 IQGAP1 LOC105370969 GC15M090794
GH15F090923 0.8 ENCODE 12.6 +54.5 54534 0.2 TAL1 ZFP64 BACH1 IRF9 ZNF316 GATA3 NCOR1 POLR2A NFE2 MAFK MAN2A2 FES FURIN LOC101926911 BLM ENSG00000200677 CRTC3 ENSG00000259661 UNC45A
GH15F090834 0.6 ENCODE 12.5 -33.7 -33715 0.5 ARID1B BCOR ZNF316 STAT1 NR4A1 IKZF1 ZEB2 FURIN FES LOC101926911 UNC45A HDDC3 ENSG00000200677 LOC105370969 GC15M090794
GH15F090867 1.5 FANTOM5 ENCODE 4.9 +2.8 2769 7.0 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ENSG00000259314 FES RCCD1 ENSG00000259212 NIFKP5 ENSG00000270322 ARPIN FURIN IQGAP1 UNC45A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FURIN on UCSC Golden Path with GeneCards custom track

Genomic Location for FURIN Gene

Chromosome:
15
Start:
90,868,592 bp from pter
End:
90,883,458 bp from pter
Size:
14,867 bases
Orientation:
Plus strand

Genomic View for FURIN Gene

Genes around FURIN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FURIN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FURIN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FURIN Gene

Proteins for FURIN Gene

  • Protein details for FURIN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P09958-FURIN_HUMAN
    Recommended name:
    Furin
    Protein Accession:
    P09958
    Secondary Accessions:
    • Q14336
    • Q6LBS3
    • Q9UCZ5

    Protein attributes for FURIN Gene

    Size:
    794 amino acids
    Molecular mass:
    86678 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and connection to clathrin adapters.

    Three dimensional structures from OCA and Proteopedia for FURIN Gene

neXtProt entry for FURIN Gene

Selected DME Specific Peptides for FURIN Gene

P09958:
  • HGTRCAGEVAA
  • GSIFVWA
  • LTWRDMQHL
  • FMTTHSWDEDP
  • TLSISSAT
  • HGTRCAGE
  • PCHASCATCQGPA
  • HTGTSASAP
  • GGVRMLDG
  • TDCLSCPSHASLDPVEQTCSRQSQSSRES
  • IYSASWGPEDDG
  • QGRGGLGSI
  • NNYGTLT
  • STLATTYSSG
  • VTDAVEARSL
  • RPHDYSADGFNDW
  • YGYGLLDAG
  • CDGYTNSI
  • HPDLAGNYDP
  • DGYTNSI
  • DPDPQPRYT
  • GIVVSILDDGIEKNHPDL
  • EPKDIGK
  • WASGNGG
  • AAGIIAL
  • CGVGVAY

Post-translational modifications for FURIN Gene

  • Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono- and non-phosphorylated forms.
  • The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition propeptide results in propeptide dissociation and furin activation.
  • Ubiquitination at Lys 748
  • Glycosylation at Asn 387, Asn 440, and Asn 553
  • Modification sites at PhosphoSitePlus

Antibody Products

Domains & Families for FURIN Gene

Gene Families for FURIN Gene

Suggested Antigen Peptide Sequences for FURIN Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P09958

UniProtKB/Swiss-Prot:

FURIN_HUMAN :
  • Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface.
  • Belongs to the peptidase S8 family. Furin subfamily.
Domain:
  • Contains a cytoplasmic domain responsible for its TGN localization and recycling from the cell surface.
  • Contains 1 peptidase S8 domain.
Family:
  • Belongs to the peptidase S8 family. Furin subfamily.
genes like me logo Genes that share domains with FURIN: view

Function for FURIN Gene

Molecular function for FURIN Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg- -Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors.
UniProtKB/Swiss-Prot EnzymeRegulation:
Could be inhibited by the not secondly cleaved propeptide.
UniProtKB/Swiss-Prot Function:
Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.

Enzyme Numbers (IUBMB) for FURIN Gene

Gene Ontology (GO) - Molecular Function for FURIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 14744861
GO:0004175 endopeptidase activity IDA,TAS --
GO:0004252 serine-type endopeptidase activity IEA,TAS --
GO:0004867 serine-type endopeptidase inhibitor activity IDA 10567353
GO:0005515 protein binding IPI 23829672
genes like me logo Genes that share ontologies with FURIN: view
genes like me logo Genes that share phenotypes with FURIN: view

Animal Models for FURIN Gene

MGI Knock Outs for FURIN:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FURIN Gene

Localization for FURIN Gene

Subcellular locations from UniProtKB/Swiss-Prot for FURIN Gene

Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans Golgi network (TGN), followed by the release of the propeptide and the activation of furin.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FURIN gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
endoplasmic reticulum 4
nucleus 3
cytosol 2
lysosome 2
endosome 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FURIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005615 NOT extracellular space IDA 10567353
GO:0005783 endoplasmic reticulum IGI 17938254
GO:0005794 Golgi apparatus IEA --
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with FURIN: view

Pathways & Interactions for FURIN Gene

genes like me logo Genes that share pathways with FURIN: view

SIGNOR curated interactions for FURIN Gene

Activates:

Gene Ontology (GO) - Biological Process for FURIN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006465 signal peptide processing IDA,TAS --
GO:0006508 proteolysis IEA --
GO:0007179 transforming growth factor beta receptor signaling pathway TAS --
GO:0008283 cell proliferation IMP 15899807
GO:0009966 regulation of signal transduction IEA --
genes like me logo Genes that share ontologies with FURIN: view

Drugs & Compounds for FURIN Gene

(27) Drugs for FURIN Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Esbriet Approved October 2014 Pharma 0
decanoic acid Experimental Pharma Full agonist, Agonist, Target 139
Pirfenidone Investigational Pharma Target TGF-β production inhibitor, Antifibrotic agent; regulates cytokine levels in vivo 49
calcium Nutra 0
PHENYLACETYL-ARG-VAL-ARG-4-AMIDINOBENZYLAMIDE Pharma 0

(24) Additional Compounds for FURIN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FURIN: view

Transcripts for FURIN Gene

Unigene Clusters for FURIN Gene

Furin (paired basic amino acid cleaving enzyme):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FURIN Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
SP1:
SP2:
SP3:

Relevant External Links for FURIN Gene

GeneLoc Exon Structure for
FURIN
ECgene alternative splicing isoforms for
FURIN

Expression for FURIN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FURIN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FURIN Gene

This gene is overexpressed in Liver (x7.4) and Whole Blood (x5.2).

Protein differential expression in normal tissues from HIPED for FURIN Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (37.9), Salivary gland (12.3), Skin (8.6), and Placenta (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FURIN Gene



NURSA nuclear receptor signaling pathways regulating expression of FURIN Gene:

FURIN

SOURCE GeneReport for Unigene cluster for FURIN Gene:

Hs.513153

mRNA Expression by UniProt/SwissProt for FURIN Gene:

P09958-FURIN_HUMAN
Tissue specificity: Seems to be expressed ubiquitously.
genes like me logo Genes that share expression patterns with FURIN: view

No data available for Protein tissue co-expression partners for FURIN Gene

Orthologs for FURIN Gene

This gene was present in the common ancestor of animals.

Orthologs for FURIN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FURIN 34 35
  • 99.5 (n)
dog
(Canis familiaris)
Mammalia FURIN 34 35
  • 90.79 (n)
cow
(Bos Taurus)
Mammalia FURIN 34 35
  • 89.76 (n)
rat
(Rattus norvegicus)
Mammalia Furin 34
  • 89.28 (n)
mouse
(Mus musculus)
Mammalia Furin 34 16 35
  • 88.52 (n)
oppossum
(Monodelphis domestica)
Mammalia FURIN 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FURIN 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FURIN 34 35
  • 77.58 (n)
lizard
(Anolis carolinensis)
Reptilia FURIN 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia furin 34
  • 67.31 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC397747 34
zebrafish
(Danio rerio)
Actinopterygii furina 34 35
  • 66.19 (n)
furinb 35
  • 63 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001330 34
  • 60.01 (n)
worm
(Caenorhabditis elegans)
Secernentea kpc-1 34
  • 56.61 (n)
Species where no ortholog for FURIN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FURIN Gene

ENSEMBL:
Gene Tree for FURIN (if available)
TreeFam:
Gene Tree for FURIN (if available)

Paralogs for FURIN Gene

Paralogs for FURIN Gene

(6) SIMAP similar genes for FURIN Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with FURIN: view

Variants for FURIN Gene

Sequence variations from dbSNP and Humsavar for FURIN Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1009957 -- 90,869,312(+) CCTGG(C/G)CTCCA intron-variant
rs1048346 -- 90,883,160(+) CTCTT(C/T)TGACG upstream-variant-2KB, utr-variant-3-prime
rs1063268 -- 90,875,688(+) GCCCT(A/G)TGACC utr-variant-5-prime
rs11073956 -- 90,869,754(+) GCCAG(C/T)CTCCA intron-variant, upstream-variant-2KB
rs111239956 -- 90,874,620(+) TAACT(C/T)CCTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FURIN Gene

Variant ID Type Subtype PubMed ID
nsv952028 CNV deletion 24416366
nsv833089 CNV loss 17160897
nsv570436 CNV loss 21841781
nsv570434 CNV loss 21841781
nsv570432 CNV gain+loss 21841781
nsv570431 CNV gain 21841781
nsv570430 CNV loss 21841781
nsv570428 CNV loss 21841781
nsv570426 CNV gain 21841781
nsv570405 CNV gain 21841781
nsv570398 CNV loss 21841781
nsv515661 CNV loss 19592680
nsv1144744 CNV deletion 24896259
esv22296 CNV loss 19812545
dgv4711n54 CNV loss 21841781
dgv4710n54 CNV gain+loss 21841781
dgv4709n54 CNV gain 21841781
dgv4708n54 CNV gain+loss 21841781
dgv4707n54 CNV gain 21841781
dgv4706n54 CNV gain+loss 21841781

Variation tolerance for FURIN Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.07; 50.72% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FURIN Gene

Human Gene Mutation Database (HGMD)
FURIN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FURIN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FURIN Gene

Disorders for FURIN Gene

MalaCards: The human disease database

(8) MalaCards diseases for FURIN Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
avian influenza
  • avian flu
dementia, familial british
  • cerebral amyloid angiopathy, itm2b-related, 1
anthrax disease
  • gas gangrene
hereditary amyloidosis
  • amyloidosis hereditary
smith-mccort dysplasia
  • smith mccort dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search FURIN in MalaCards View complete list of genes associated with diseases

Relevant External Links for FURIN

Genetic Association Database (GAD)
FURIN
Human Genome Epidemiology (HuGE) Navigator
FURIN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FURIN
genes like me logo Genes that share disorders with FURIN: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FURIN Gene

Publications for FURIN Gene

  1. PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic. (PMID: 11331585) Crump C.M. … Thomas G. (EMBO J. 2001) 3 4 22 64
  2. Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail. (PMID: 8846780) Jones B.G. … Thomas G. (EMBO J. 1995) 3 4 22 64
  3. Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. (PMID: 1629222) Leduc R. … Thomas G. (J. Biol. Chem. 1992) 3 4 22 64
  4. Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. (PMID: 2251280) Wise R.J. … Kaufman R.J. (Proc. Natl. Acad. Sci. U.S.A. 1990) 2 3 4 64
  5. Polymorphisms in the transforming growth factor beta 1 pathway in relation to colorectal cancer progression. (PMID: 19998449) FAPrsti A. … Lenner P. (Genes Chromosomes Cancer 2010) 3 46 64

Products for FURIN Gene

Sources for FURIN Gene

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