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FURIN Gene

protein-coding   GIFtS: 65

GC15P089212
furin (paired basic amino acid cleaving enzyme)
(Previous names: paired basic amino acid cleaving enzyme (furin, membrane associated receptor protein) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PCSK3, FUR, PACE)
Services    

Aliases &
Descriptions
for FURIN

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
EC 3.4.21.75 3
FUR 2, 3, 5
PACE 2, 3, 5
PCSK3 2, 3, 5
SPC1 1, 2
furin 2
Descriptions
Dibasic-processing enzyme 3
FES upstream region 2
Paired basic amino acid residue cleaving enzyme 3
dibasic processing enzyme 2
furin (paired basic amino acid cleaving enzyme) 2
furin, membrane associated receptor protein 2
paired basic amino acid cleaving enzyme (furin, membrane
associated receptor protein) 1
proprotein convertase subtilisin/kexin type 3 2
External Ids
HGNC: 85681
Entrez Gene: 50452
UniProtKB: P099583
Ensembl: ENSG000001405647
Search outside databases for aliases for FURIN gene

Previous GC identifers: GC15P084851 GC15P088999 GC15P089141

Summaries
for FURIN

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for FURIN:
The protein encoded by this gene belongs to the subtilisin-like proprotein convertase family. The
members of this family are proprotein convertases that process latent precursor proteins into
their biologically active products. This encoded protein is a calcium-dependent serine
endoprotease that can efficiently cleave precursor proteins at their paired basic amino acid
processing sites. Some of its substrates are: proparathyroid hormone, transforming growth factor
beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta
subunit of pro-nerve growth factor and von Willebrand factor. It is also thought to be one of the
proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140. This gene
is thought to play a role in tumor progression. The use of alternate polyadenylation sites has
been found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958
Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive
secretory pathways and capable of cleavage at the RX(K/R)R consensus motif

Gene Wiki entry for FURIN (Furin)

Genomic Location
for FURIN

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FURIN gene  

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

FURIN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P089212:     (about GC identifiers)

Start:
 89,212,889 bp from pter
End:
 89,227,691 bp from pter
Size:
 14,803 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000015.8  NT_010274.16  

Proteins
for FURIN

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958 (See protein sequence)
Recommended Name: Furin precursor  
Size: 794 amino acids; 86678 Da
Cofactor: Calcium
Subunit: Interacts with FLNA (By similarity). Binds to PACS1 which mediates TGN localization and
connection to clathrin adapters
Subcellular location: Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane
protein. Cell membrane; Single-pass type I membrane protein. Note=Shuttles between the trans-Golgi
network and the cell surface. Propeptide cleavage is a prerequisite for exit of furin molecules
out of the endoplasmic reticulum (ER). A second cleavage within the propeptide occurs in the trans
Golgi network (TGN), followed by the release of the propeptide and the activation of furin
Secondary accessions: Q14336 Q6LBS3 Q9UCZ5

Post-translational modifications:

  • The inhibition peptide, which plays the role of an intramolecular chaperone, is autocatalytically
    removed in the endoplasmic reticulum (ER) and remains non-covalently bound to furin as a potent
    autoinhibitor. Following transport to the trans Golgi, a second cleavage within the inhibition
    propeptide results in propeptide dissociation and furin activation1
  • Phosphorylation is required for TGN localization of the endoprotease. In vivo, exists as di-, mono-
    and non-phosphorylated forms1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_002560.1  

    ENSEMBL proteins: 
    ENSP00000268171 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for FURIN  
    R&D Systems Recombinant & Natural Proteins for FURIN
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Furin, Prohormone convertase 1 + 2 + 3)
    Human Recombinant Proteins from Abnova (FURIN)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139 Golgi membrane EXP8615794
    GO:0005615NOT extracellular space IDA10567353
    GO:0005794 Golgi apparatus IEA--
    GO:0005802 trans-Golgi network IDA14744861
    GO:0005886 plasma membrane IEA--
    About this table

    Antibodies for FURIN: 
    Invitrogen Antibodies for FURIN
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for FURIN
    R&D Systems Antibodies for FURIN
    Antibodies from Abcam (Furin, Prohormone convertase 1 + 2 + 3), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibody for FURIN

    Assays for FURIN: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    R&D Systems ELISAs for FURIN         (see all)
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for FURIN

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro domains/families:
     IPR002884 PrprotnconvertsP
     IPR006212 Furin_repeat
     IPR000209 Pept_S8_S53
     IPR015500 Peptidase_S8_subtilisin-rel


       GeneDecks  FURIN for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P09958

    ProtoNet protein and cluster: P09958

    3 Blocks protein families:
    IPB000209 Subtilisin serine protease family (S8) signature
    IPB002884 Proprotein convertase
    IPB006212 Furin-like repeat


    UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958
    Domain: Contains a cytoplasmic domain responsible for its TGN localization and recycling from the
    cell surface
    Similarity: Belongs to the peptidase S8 family. Furin subfamily
    Similarity: Contains 1 homo B/P domain

    Gene Function
    for FURIN

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (FURIN)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FURIN)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002569

                  Applied Biosystems Silencer® siRNAs for FURIN

                  Sigma-Aldrich siRNA and siRNA Panels for FURIN  
                         Sigma-Aldrich shRNA for FURIN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for FURIN
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002569
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002569
                                     untagged cDNA clone in CMV expression vector: NM_002569 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002569

    UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958
    Function: Furin is likely to represent the ubiquitous endoprotease activity within constitutive
    secretory pathways and capable of cleavage at the RX(K/R)R consensus motif
    Catalytic activity: Release of mature proteins from their proproteins by cleavage of
    -Arg-Xaa-Yaa-Arg- -Zaa- bonds, where Xaa can be any amino acid and Yaa is Arg or Lys. Releases
    albumin, complement component C3 and vWF from their respective precursors
    Enzyme regulation: Could be inhibited by the not secondly cleaved propeptide
    Enzyme Number (IUBMB): EC 3.4.21.75 

    7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Furin):

    embryogenesisgrowth/sizelethality-prenatal/perinatalliver/biliary system
    nervous systemnormal

    5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020 protease binding IPI14744861
    GO:0004252 serine-type endopeptidase activity IEA--
    GO:0004867 serine-type endopeptidase inhibitor activity IDA10567353
    GO:0005509 calcium ion binding IEA--
    GO:0005515 protein binding IEA--
    About this table

    Pathways & Interactions
    for FURIN

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Millipore Pathway for FURIN
     Development Notch Signaling Pathway

       GeneDecks  FURIN for the pathways selected above  
    About GeneDecksing

    2 Sigma-Aldrich "Your Favorite Gene" Pathways for  FURIN  (Your Favorite Gene powered by Ingenuity) 
     Notch Signaling
     Lysine Degradation

       GeneDecks  FURIN for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  FURIN 


    5/91 Interacting proteins for FURIN (ENSP000002681713 P099582) via UniProtKB, MINT, and/or STRING (see all 91 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TGOLN2O434932STRING (score=.919) MINT-3372400
    PACS1ENSP000003164543STRING (score=.995)
    NOTCH1ENSP000003607653STRING (score=.99)
    ADAMTS4ENSP000003569753STRING (score=.978)
    THBS1ENSP000002603563STRING (score=.978)
    About this table

    5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006465 signal peptide processing IDA16912035
    GO:0008283 cell proliferation IMP15899807
    GO:0019067 viral assembly, maturation, egress, and release IEP8940009
    GO:0032455 nerve growth factor processing EXP12787574
    GO:0032804 negative regulation of low-density lipoprotein receptor catabolic process IDA16912035
    About this table

    Drugs & Compounds
    for FURIN

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Enzo Life Sciences drugs & compounds for FURIN
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for FURIN
    10/34 Novoseek chemical compound relationships for FURIN gene (see all 34 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dfurin2 86.29 3 1512259 (2)
    arg-arg 70.92 1 8846780 (1)
    exotoxin-a 68.42 10 9169757 (3), 7989356 (2), 9636142 (1), 10600112 (1) (see all 5)
    prosomatostatin 59.82 3 7619075 (2), 8095501 (1)
    peptidylglycine 54.67 2 7865135 (1), 8402152 (1)
    mannose 6-phosphate 50.08 5 10547356 (1), 11331585 (1), 11014362 (1), 9695949 (1) (see all 5)
    preproinsulin 47.47 2 15821105 (1), 11874714 (1)
    proglucagon 43.21 3 15528303 (1), 12651102 (1)
    tgf beta1 39.75 10 11424093 (2), 14644155 (2), 11014362 (2), 10099264 (1) (see all 6)
    monensin 39.33 2 18992360 (1)
    About this table


    Transcripts
    for FURIN

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (FURIN)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (FURIN)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002569

                  Sigma-Aldrich siRNA and siRNA Panels for FURIN  
                         Sigma-Aldrich shRNA for FURIN  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002569  

    REFSEQ mRNAs for FURIN gene: 

    NM_002569.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002569  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_002569
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_002569
                                     untagged cDNA clone in CMV expression vector: NM_002569 

    Additional cDNA sequence: 

    AL110107.1 BC008295.1 BC012181.1 S65442.1 X17094.1 

    9 DOTS entries:

    DT.447619  DT.91774265  DT.100733268  DT.121062643  DT.97796995  DT.100786346  DT.121062677  DT.95246560 
    DT.95246561 

    24/296 AceView cDNA sequences (see all 296 ):

    BC008295 AI797049 X17094 BF196808 BE219000 AW467853 BQ668619 BU191560 
    BQ669905 AI633315 AW964052 AI222953 BQ690452 AW403605 BU542206 BM311681 
    NM_002569 BM311086 BC012181 BM830768 BQ636937 BM917196 BU625529 BQ880122 

    highest scoring ESTs for FURIN:

    X17094 AA037089 AA186708 AA203402 AA325040 AA447140 AA548568 AA654637 AA707055 AA827773 

    Unigene Cluster for FURIN:

    Furin (paired basic amino acid cleaving enzyme)
    Hs.513153  [show with all ESTs]
    Unigene Representative Sequence: NM_002569


    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for FURIN

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15
    SP1:                                                                                                            
    SP2:                                                                                                            
    SP3:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for FURIN

    1 Ensembl transcript including schematic representation:
    ENST00000268171  

    Expression
    for FURIN

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    FURIN expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for FURIN

    1 / 2 / 3

    3 probe-sets matching FURIN gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35338_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X17094 1.00 1.00 1.00 1

    		201945_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002569 0.60 1.00 0.82 1

    		201945_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  FURIN for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: AGATAATGTT

    SOURCE GeneReport for Unigene cluster: Hs.513153

    Expression variation in blood from EXPOLDB for FURIN

    UniProtKB/Swiss-Prot: FURIN_HUMAN, P09958
    Tissue specificity: Seems to be expressed ubiquitously

    Orthologs
    for FURIN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for FURIN gene from 5/13 species (see all 13 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 FURIN1   -- furin (paired basic amino acid cleaving enzyme) 89.83(n)
    94.33(a)    		 488746  XM_545864.2  XP_545864.2 
    chimpanzee
    (Pan troglodytes)    		 FURIN1   -- furin (paired basic amino acid cleaving enzyme) 99.5(n)
    99.75(a)    		 453652  XM_510596.2  XP_510596.2 
    cow
    (Bos taurus)    		 FURIN1   -- furin (paired basic amino acid cleaving enzyme) 90.51(n)
    95.21(a)    		 281374  NM_174136.2  NP_776561.1 
    rat
    (Rattus norvegicus)    		 Furin1   -- furin (paired basic amino acid cleaving enzyme) 89.28(n)
    93.82(a)    		 54281  NM_019331.1  NP_062204.1 
    mouse
    (Mus musculus)    		 Furin1, 5 7 (39.00 cM)5
    		 furin (paired basic amino acid cleaving enzyme)1, 5 88.52(n)1
    93.95(a)1    		 185501  NM_011046.21  NP_035176.11 
     AF5423945  AK0202945  (see all 11)
    About this table        Species with no ortholog for FURIN

    ENSEMBL Gene Tree for FURIN

    Paralogs
    for FURIN

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for FURIN gene
    PCSK42  PCSK62  PCSK52  

    SNPs/Variants
    for FURIN

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/83 NCBI SNPs in FURIN are shown (see all 83 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 74)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs62271,2
    		C,F,H,O89226236(+) GACTGC/TTTCCC 1 -- ut31 ese313Minor allele frequency- T:0.23MN EA EU WA NA 1458
    rs37599291,2
    		C,F,H89211013(-) ACAAAC/AAGAAG 1 -- ng51 tfbs35Minor allele frequency- A:0.23EA EU WA 1912
    rs62281,2
    		C,F,H89226499(+) TCCAGG/ACAGTC 1 -- ut316Minor allele frequency- A:0.06MN EU EA WA 678
    rs169449711,2
    		C,F,H89220102(+) CCCAGC/TGGTGG 1 A/V mis1 ese312Minor allele frequency- T:0.23NA EU EA WA 1022
    rs49321781,2
    		C,F,H89212660(+) CAGACC/TCACCC 1 -- ng514Minor allele frequency- T:0.27EU EA WA 420
    rs62261,2
    		A,C,F89225578(+) CCAGGC/GTTCGC 1 G/G syn13Minor allele frequency- G:0.25MN NA 324
    rs19814581,2
    		C,F,H,O89217609(+) ACTTTT/CAACGC 1 -- int17Minor allele frequency- C:0.13EU EA WA NA 558
    rs80323151,2
    		A,C,F,H89219301(+) atcgtT/Actgtc 1 -- int14Minor allele frequency- A:0.23EU EA WA 420
    rs45269961,2
    		C,F,H89219595(+) CTTGCA/GTGGAG 1 -- int112Minor allele frequency- G:0.04EU EA WA 1256
    rs20714101,2
    		C,F,H89221944(+) TTTCCC/GACTGT 1 -- int111Minor allele frequency- G:0.14EA EU WA NA 2498
    About this table

    HapMap Linkage Disequilibrium images for FURIN (up to first 250kb)

    Disorders & Mutations
    for FURIN

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 136950

    10/38 Novoseek disease relationships for FURIN gene (see all 38 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    dementia, familial british 82.81 2 10526337 (1), 12883829 (1)
    anthrax 71.13 25 1644824 (2), 16041026 (2), 18977558 (2), 14688144 (2) (see all 14)
    amyloidosis familial 66.00 3 14596804 (1), 14675544 (1), 11707399 (1)
    fowl plague 47.19 2 1360148 (1), 1628614 (1)
    colon carcinoma 46.52 15 7690548 (2), 12691605 (1), 12782675 (1), 7707552 (1) (see all 9)
    ectodermal dysplasia, hypohidrotic 40.23 1 11416205 (1)
    influenza 32.61 10 8057485 (3), 10074171 (1), 7562936 (1), 10219565 (1) (see all 8)
    diphtheria 29.23 3 18089813 (1), 8253774 (1)
    colon adenocarcinoma 28.49 4 12736257 (1), 8760366 (1), 12058031 (1), 8057485 (1)
    immunodeficiency 26.78 13 8189547 (2), 8325837 (1), 8163529 (1), 10567353 (1) (see all 12)
    About this table

    Genetic Association Database: FURIN

    Medical News
    for FURIN

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for FURIN

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/386 PubMed articles for FURIN gene (see all 386 ):

    Search for FURIN

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing FURIN

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 5045 HGNC: 8568 AceView: FURIN Ensembl:ENSG00000140564 euGenes: HUgn5045
    ECgene: FURIN H-InvDB: FURIN

    Other Databases showing FURIN

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing FURIN

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for FURIN Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for FURIN

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for FURIN

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for FURIN:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for FURIN-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for FURIN Antibodies for FURIN
     Explore super-pooled esiRNAs Proteins for FURIN
     Lentivirus-delivered shRNAs for FURIN Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (FURIN)
     Search for Antibodies
     Chimera RNAi (FURIN)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (Furin, Prohormone convertase 1 + 2 + 3)
     Antibodies (Furin, Prohormone convertase 1 + 2 + 3)
     Search OriGene for FURIN
     Search Tocris compounds for FURIN




     Drugs for FURIN
     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for FURIN

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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    Developed at the Crown Human Genome Center & Weizmann Institute of Science



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