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Aliases for FUOM Gene

Aliases for FUOM Gene

  • Fucose Mutarotase 2 3 5
  • C10orf125 3 4
  • Chromosome 10 Open Reading Frame 125 2
  • Protein FucU Homolog 3
  • EC 5.1.3.29 4
  • FUCU 3
  • FucM 3

External Ids for FUOM Gene

Previous HGNC Symbols for FUOM Gene

  • C10orf125

Previous GeneCards Identifiers for FUOM Gene

  • GC10M135169

Summaries for FUOM Gene

GeneCards Summary for FUOM Gene

FUOM (Fucose Mutarotase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include isomerase activity and fucose binding.

UniProtKB/Swiss-Prot for FUOM Gene

  • Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.

Additional gene information for FUOM Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUOM Gene

Genomics for FUOM Gene

Regulatory Elements for FUOM Gene

Enhancers for FUOM Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10H133356 1.3 Ensembl ENCODE 10.7 -0.8 -792 4.5 ATF1 FOXA2 MLX ZFP64 ARID4B YY1 TCF12 GLIS2 GATA2 ZNF143 SCART1 TUBGCP2 FUOM ENSG00000235245 PRAP1 ECHS1 PAOX GC10P133359
GH10H133346 0.9 ENCODE 10.3 +10.3 10273 2.2 ARID4B THRB RAD21 RARA YY1 CREM EGR2 SP5 ZNF398 PPARG FUOM ECHS1 PRAP1 ENSG00000226699
GH10H132683 1.4 Ensembl ENCODE dbSUPER 4.3 +672.8 672752 2.6 ELF3 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 FOS SP5 CEBPB NKX6-2 INPP5A FUOM PIR45643
GH10H133292 1.2 FANTOM5 Ensembl ENCODE 4.7 +64.4 64427 2.3 FOSL1 ZNF121 JUND POLR2A JUN FOS ECHS1 ADAM8 FUOM TUBGCP2 ENSG00000235245 PIR44208 GC10P133285
GH10H133334 1.2 Ensembl ENCODE 4.6 +22.3 22274 2.9 ATF1 ZNF473 ZSCAN4 KLF17 SIN3A GLI4 BMI1 ZNF23 GLIS2 EGR1 SCART1 ZNF511 PAOX ECHS1 TUBGCP2 VENTX MTG1 FUOM CALY GC10M133326
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FUOM on UCSC Golden Path with GeneCards custom track

Promoters for FUOM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000035545 435 1201 TBP TBL1XR1 ZFP64 ZBTB40 THRB RARA YY1 GLIS2 EGR1 ZNF143

Genomic Locations for FUOM Gene

Genomic Locations for FUOM Gene
chr10:133,352,775-133,358,035
(GRCh38/hg38)
Size:
5,261 bases
Orientation:
Minus strand
chr10:135,168,658-135,171,529
(GRCh37/hg19)

Genomic View for FUOM Gene

Genes around FUOM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUOM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUOM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUOM Gene

Proteins for FUOM Gene

  • Protein details for FUOM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VDF0-FUCM_HUMAN
    Recommended name:
    Fucose mutarotase
    Protein Accession:
    A2VDF0
    Secondary Accessions:
    • A1L300
    • Q5VWY2
    • Q5VWY3
    • Q6ZPD2

    Protein attributes for FUOM Gene

    Size:
    154 amino acids
    Molecular mass:
    16765 Da
    Quaternary structure:
    • Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive (By similarity).
    SequenceCaution:
    • Sequence=CAH70284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH70285.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FUOM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUOM Gene

Post-translational modifications for FUOM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FUOM Gene

Domains & Families for FUOM Gene

Gene Families for FUOM Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FUOM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FUOM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2VDF0

UniProtKB/Swiss-Prot:

FUCM_HUMAN :
  • Belongs to the RbsD / FucU family.
Family:
  • Belongs to the RbsD / FucU family.
genes like me logo Genes that share domains with FUOM: view

Function for FUOM Gene

Molecular function for FUOM Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-L-fucose = beta-L-fucose.
UniProtKB/Swiss-Prot Function:
Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.

Enzyme Numbers (IUBMB) for FUOM Gene

Phenotypes From GWAS Catalog for FUOM Gene

Gene Ontology (GO) - Molecular Function for FUOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016853 isomerase activity IEA --
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives TAS --
GO:0042806 fucose binding ISS --
GO:0048029 monosaccharide binding IEA --
genes like me logo Genes that share ontologies with FUOM: view
genes like me logo Genes that share phenotypes with FUOM: view

Animal Models for FUOM Gene

MGI Knock Outs for FUOM:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FUOM Gene

Localization for FUOM Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUOM gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for FUOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FUOM: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FUOM Gene

Pathways & Interactions for FUOM Gene

genes like me logo Genes that share pathways with FUOM: view

Interacting Proteins for FUOM Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357540%0d%0a9606.ENSP00000245323%0d%0a9606.ENSP00000357392%0d%0a
Selected Interacting proteins: ENSP00000357540 A2VDF0-FUCM_HUMAN for FUOM Gene via STRING IID

Gene Ontology (GO) - Biological Process for FUOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005996 monosaccharide metabolic process IEA --
GO:0006004 fucose metabolic process ISS --
GO:0036065 fucosylation IEA --
GO:0045665 negative regulation of neuron differentiation IEA --
GO:0060180 female mating behavior IEA --
genes like me logo Genes that share ontologies with FUOM: view

No data available for SIGNOR curated interactions for FUOM Gene

Drugs & Compounds for FUOM Gene

(2) Drugs for FUOM Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-L-fucose Experimental Pharma 0
beta-L-fucose Experimental Pharma 0
genes like me logo Genes that share compounds with FUOM: view

Transcripts for FUOM Gene

Unigene Clusters for FUOM Gene

Fucose mutarotase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUOM Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: -

Relevant External Links for FUOM Gene

GeneLoc Exon Structure for
FUOM
ECgene alternative splicing isoforms for
FUOM

Expression for FUOM Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUOM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUOM Gene

This gene is overexpressed in Liver (x13.6) and Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for FUOM Gene

This gene is overexpressed in Liver, secretome (33.8), Liver (15.1), and Gallbladder (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUOM Gene



Protein tissue co-expression partners for FUOM Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FUOM Gene:

FUOM

SOURCE GeneReport for Unigene cluster for FUOM Gene:

Hs.155823

Evidence on tissue expression from TISSUES for FUOM Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with FUOM: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUOM Gene

Orthologs for FUOM Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUOM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUOM 33 34
  • 99.13 (n)
dog
(Canis familiaris)
Mammalia FUOM 33 34
  • 84.77 (n)
cow
(Bos Taurus)
Mammalia FUOM 33 34
  • 83.78 (n)
rat
(Rattus norvegicus)
Mammalia LOC100911225 33
  • 80.7 (n)
mouse
(Mus musculus)
Mammalia Fuom 33 16 34
  • 79.61 (n)
oppossum
(Monodelphis domestica)
Mammalia FUOM 34
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fuom 33 34
  • 63.04 (n)
sizc217g15.3 33
Species where no ortholog for FUOM was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUOM Gene

ENSEMBL:
Gene Tree for FUOM (if available)
TreeFam:
Gene Tree for FUOM (if available)

Paralogs for FUOM Gene

No data available for Paralogs for FUOM Gene

Variants for FUOM Gene

Sequence variations from dbSNP and Humsavar for FUOM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1000589020 -- 133,355,566(+) GGGGC(C/T)CTGCC intron-variant
rs1000958148 -- 133,355,309(+) GAGTG(A/G)TGGTA intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1001017078 -- 133,356,910(+) CACGG(A/C)GCAGC intron-variant
rs1001713961 -- 133,355,037(+) AGTCC(C/T)CAGGG downstream-variant-500B, utr-variant-3-prime
rs1001746720 -- 133,355,235(+) CACCC(A/C/G)AAGAC intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FUOM Gene

Variant ID Type Subtype PubMed ID
nsv952707 CNV deletion 24416366
nsv832040 CNV loss 17160897
nsv832036 CNV loss 17160897
nsv552644 CNV loss 21841781
nsv552589 CNV gain 21841781
nsv528260 CNV loss 19592680
nsv527785 CNV loss 19592680
nsv470980 CNV loss 18288195
nsv467509 CNV loss 19166990
nsv428243 CNV gain 18775914
nsv1052904 CNV gain 25217958
nsv1037772 CNV gain 25217958
esv3625043 CNV gain 21293372
esv3625030 CNV gain 21293372
esv2759793 CNV gain+loss 17122850
esv2750853 CNV gain 17911159
dgv3e196 CNV duplication 17116639
dgv2e196 CNV duplication 17116639

Variation tolerance for FUOM Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUOM Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUOM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUOM Gene

Disorders for FUOM Gene

Relevant External Links for FUOM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUOM

No disorders were found for FUOM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUOM Gene

Publications for FUOM Gene

  1. Characterization and role of fucose mutarotase in mammalian cells. (PMID: 17602138) Park D … Park C (Glycobiology 2007) 2 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M … Lindquist S (Cell 2014) 3 60
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 60
  5. Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase. (PMID: 19524593) Lee KH … Oh BH (Journal of molecular biology 2009) 3 60

Products for FUOM Gene

Sources for FUOM Gene

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