FUOM Gene
protein-coding GIFtS: 36
GCID: GC10M135169
|
|
fucose mutarotase(Previous name: chromosome 10 open reading frame 125 )
(Previous symbol: C10orf125)
| |
Aliases
for FUOM gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fucose Mutarotase1 2 | | Chromosome 10 Open Reading Frame 1251 | | C10orf1251 2 3 | | FUCU2 | | FucM1 2 | | Protein FucU Homolog2 | | FLJ260161 | | EC 5.1.3.N21 | | FucU1 | | |
Export aliases for FUOM gene to outside databases |
Summaries
for FUOM gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FUCM_HUMAN, A2VDF0Function: Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists asalpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway.GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where itserves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cellsurfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognitionprocesses
|
Genomic Views
for FUOM gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000010.10 NC_018921.1 NT_008818.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for FUOM
Other transcription factors
Search SABiosciences Chromatin IP Primers for FUOM
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUOM |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 10q26.3 Ensembl cytogenetic band: 10q26.3 HGNC cytogenetic band: 10q26.3FUOM Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 10 GeneLoc Exon Structure GeneLoc location for GC10M135169: view genomic region
(about GC identifiers)
Start:
|
135,168,658 bp from pter |
End:
|
135,171,529 bp from pter |
Size:
|
2,872 bases |
Orientation:
|
minus strand |
|
Proteins
for FUOM gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FUCM_HUMAN, A2VDF0 (See
protein sequence)Recommended Name: Fucose mutarotase Size: 154 amino acids; 16765 Da
Subunit: Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seemscatalytically inactive (By similarity)
Sequence caution: Sequence=CAH70284.1; Type=Erroneous gene model prediction; Sequence=CAH70285.1; Type=Erroneous genemodel prediction;
Secondary accessions: A1L300 Q5VWY2 Q5VWY3 Q6ZPD2Alternative splicing: 2 isoforms: A2VDF0-1 A2VDF0-2 Explore the universe of human proteins at neXtProt for FUOM: NX_A2VDF0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A2VDF0
FUOM Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001091953.1 NP_940874.2
ENSEMBL proteins: ENSP00000413379 ENSP00000357539 ENSP00000357540 ENSP00000278025
Human Recombinant Protein Products:
FUOM Antibody Products:
Assay Products for FUOM: |
Protein
Domains /
Families
for FUOM gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FUOM for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A2VDF0ProtoNet protein and cluster: A2VDF0 UniProtKB/Swiss-Prot: FUCM_HUMAN, A2VDF0Similarity: Belongs to the RbsD / FucU family |
Function
for FUOM gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FUCM_HUMAN, A2VDF0Function: Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists asalpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway.GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where itserves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cellsurfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognitionprocessesCatalytic activity: Alpha-L-fucose = beta-L-fucoseEnzyme Number (IUBMB): EC 5.1.3.n21
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUOM (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUOM (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for FUOM | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUOM | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUOM |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives |
ISS | -- | | GO:0042806 | fucose binding |
ISS | -- |
FUOM for ontologies About GeneDecksing
Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Fuom):
FUOM for phenotypes About GeneDecksing
|
Pathways & Interactions
for FUOM gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUOM
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FUOM (ENSP000003575404) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006004 | fucose metabolic process |
ISS | -- |
FUOM for ontologies About GeneDecksing
|
Drugs & Compounds
for FUOM gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FUOM
Search CenterWatch for drugs/clinical trials and news about FUOM / FUCM
|
Transcripts
for FUOM gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FUOM gene (2 alternative transcripts): NM_001098483.1 NM_198472.2 Unigene Cluster for FUOM: Fucose mutarotase Hs.155823 [show with all ESTs]Unigene Representative Sequence: BQ2776436 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000447176 ENST00000465384 ENST00000368551 ENST00000478895 ENST00000368552(uc001lmt.2)
ENST00000278025(uc001lms.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUOM (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUOM (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for FUOM | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUOM | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUOM |
Additional cDNA sequence: AK129527.1 AK310070.1 BC129818.1 BC129819.1 5 DOTS entries: DT.75100305 DT.101979068 DT.427390 DT.100745610 DT.100017152 24/27 AceView cDNA sequences (see all 27): BX119427 BE646025 AI682430 BU849497 AI333356 CK299563 AA371739 AK129527 BM009909 BM797299 NM_198472 BQ277643 AI657157 CD365619 BQ189431 T48398 AI269186 BU597947 BI197701 BE675283 BF206345 CB048432 AA715323 AI471699
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for FUOM (see all 7) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | | | - | | - | | - | | | | | | | | - | | | | | | - | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | - | | | | | | - | | - | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | - | | - | | | | | | |
| SP4: | | | | | - | | - | | - | | - | | | | | | - | | | | | | - | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FUOM
|
Expression
for FUOM gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --
See FUOM Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FUOM
SOURCE GeneReport for Unigene cluster: Hs.155823
SABiosciences Custom PCR Arrays for FUOM
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUOM
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat FUOM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUOM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUOM |
Orthologs
for FUOM gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FUOM gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for FUOM (if available)
TreeFam Gene Tree for FUOM (if available) |
Paralogs
for FUOM gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for FUOM gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 10 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FUOM (135168658 - 135171529 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FUOM: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUOM |
|
Disorders
/ Diseases
for FUOM gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FUOM for disorders About GeneDecksing
2  diseases for FUOM: About MalaCardsalzheimer's disease pneumonia
Export disorders for FUOM gene to outside databases
|
Publications
for FUOM gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FUOM gene integrated from 9 sources:
(articles sorted by number of sources associating them with FUOM) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization and role of fucose mutarotase in mam malian cells. (PubMed id 17602138)1, 2, 3 Park D....Park C. (2007)
- Crystal structures and enzyme mechanisms of a dual fu cose mutarotase/ribose pyranase. (PubMed id 19524593)1 Lee K.H....Oh B.H. (2009)
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1 Grupe A....Goate A. (2006)
- The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)2 Deloukas P.... Rogers J. (2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FUOM gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FUOM gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FUOM gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FUOM gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FUOM | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FUOM gene:
Search GeneIP for patents involving FUOM
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FUOM gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FUOM | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUOM | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUOM | | | OriGene Protein Over-expression Lysate for FUOM | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FUOM | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUOM | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUOM | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FUOM | | OriGene Custom Protein Services for FUOM | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FUOM | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUOM | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUOM | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUOM | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUOM | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUOM |
| |
 |  |  |  | |
| | | | Search Tocris compounds for FUOM |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | FUOM Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for FUOM |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUOM |
|
|
|
|
