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Aliases for FUOM Gene

Aliases for FUOM Gene

  • Fucose Mutarotase 2 3
  • C10orf125 3 4
  • Chromosome 10 Open Reading Frame 125 2
  • Protein FucU Homolog 3
  • EC 5.1.3.29 4
  • FUCU 3
  • FucM 3

External Ids for FUOM Gene

Previous HGNC Symbols for FUOM Gene

  • C10orf125

Previous GeneCards Identifiers for FUOM Gene

  • GC10M135169

Summaries for FUOM Gene

GeneCards Summary for FUOM Gene

FUOM (Fucose Mutarotase) is a Protein Coding gene. GO annotations related to this gene include fucose binding and racemase and epimerase activity, acting on carbohydrates and derivatives.

UniProtKB/Swiss-Prot for FUOM Gene

  • Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUOM Gene

Genomics for FUOM Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FUOM Gene

Start:
133,355,154 bp from pter
End:
133,358,025 bp from pter
Size:
2,872 bases
Orientation:
Minus strand

Genomic View for FUOM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUOM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUOM Gene

No data available for Regulatory Elements for FUOM Gene

Proteins for FUOM Gene

  • Protein details for FUOM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VDF0-FUCM_HUMAN
    Recommended name:
    Fucose mutarotase
    Protein Accession:
    A2VDF0
    Secondary Accessions:
    • A1L300
    • Q5VWY2
    • Q5VWY3
    • Q6ZPD2

    Protein attributes for FUOM Gene

    Size:
    154 amino acids
    Molecular mass:
    16765 Da
    Quaternary structure:
    • Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive (By similarity).
    SequenceCaution:
    • Sequence=CAH70284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH70285.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FUOM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUOM Gene

Proteomics data for FUOM Gene at MOPED

Post-translational modifications for FUOM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FUOM Gene

No data available for DME Specific Peptides for FUOM Gene

Domains for FUOM Gene

Protein Domains for FUOM Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

A2VDF0

UniProtKB/Swiss-Prot:

FUCM_HUMAN :
  • A2VDF0
Family:
  • Belongs to the RbsD / FucU family.
genes like me logo Genes that share domains with FUOM: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for FUOM Gene

Function for FUOM Gene

Molecular function for FUOM Gene

UniProtKB/Swiss-Prot CatalyticActivity: Alpha-L-fucose = beta-L-fucose.
UniProtKB/Swiss-Prot Function: Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.

Enzyme Numbers (IUBMB) for FUOM Gene

Gene Ontology (GO) - Molecular Function for FUOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016853 isomerase activity --
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives ISS --
GO:0042806 fucose binding ISS --
GO:0048029 monosaccharide binding --
genes like me logo Genes that share ontologies with FUOM: view
genes like me logo Genes that share phenotypes with FUOM: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUOM

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FUOM Gene

Localization for FUOM Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FUOM Gene

Pathways for FUOM Gene

SuperPathways for FUOM Gene

No Data Available

Interacting Proteins for FUOM Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357540%0d%0a9606.ENSP00000239690%0d%0a
Selected Interacting proteins: ENSP00000357540 for FUOM Gene via STRING

Symbol External ID(s) Details
NUDCD1

Gene Ontology (GO) - Biological Process for FUOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005996 monosaccharide metabolic process --
GO:0006004 fucose metabolic process ISS --
GO:0036065 fucosylation --
GO:0045665 negative regulation of neuron differentiation --
GO:0060180 female mating behavior --
genes like me logo Genes that share ontologies with FUOM: view

No data available for Pathways by source for FUOM Gene

Transcripts for FUOM Gene

Unigene Clusters for FUOM Gene

Fucose mutarotase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUOM

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for FUOM
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUOM Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: -

Relevant External Links for FUOM Gene

GeneLoc Exon Structure for
FUOM
ECgene alternative splicing isoforms for
FUOM

Expression for FUOM Gene

mRNA expression in normal human tissues for FUOM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUOM Gene

This gene is overexpressed in Liver (13.6) and Kidney - Cortex (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUOM Gene

SOURCE GeneReport for Unigene cluster for FUOM Gene Hs.155823

genes like me logo Genes that share expressions with FUOM: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FUOM Gene

Orthologs for FUOM Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUOM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUOM 35
  • 99.13 (n)
  • 98.05 (a)
FUOM 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUOM 35
  • 83.78 (n)
  • 82.43 (a)
FUOM 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUOM 35
  • 84.77 (n)
  • 86.75 (a)
FUOM 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fuom 35
  • 79.61 (n)
  • 80.92 (a)
Fuom 16
Fuom 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUOM 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fuom 35
  • 80.7 (n)
  • 81.58 (a)
zebrafish
(Danio rerio)
Actinopterygii fuom 35
  • 63.04 (n)
  • 68.71 (a)
fuom 36
  • 66 (a)
OneToOne
sizc217g15.3 35
Species with no ortholog for FUOM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUOM Gene

ENSEMBL:
Gene Tree for FUOM (if available)
TreeFam:
Gene Tree for FUOM (if available)

Paralogs for FUOM Gene

No data available for Paralogs for FUOM Gene

Variants for FUOM Gene

Sequence variations from dbSNP and Humsavar for FUOM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1057097 -- 133,355,253(-) GGGCT(C/T)TAGGG downstream-variant-500B, utr-variant-3-prime
rs1891372 -- 133,357,860(+) CCCCG(C/T)GCAAG intron-variant
rs2096169 -- 133,359,348(+) CCTGT(A/G)ATCCC upstream-variant-2KB
rs12254415 -- 133,359,433(+) acccc(A/G)tctct upstream-variant-2KB
rs28555072 -- 133,358,087(+) GGCTT(A/G)GGGGC upstream-variant-2KB

Relevant External Links for FUOM Gene

HapMap Linkage Disequilibrium report
FUOM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FUOM Gene

Disorders for FUOM Gene

No disorders were found for FUOM Gene.

No data available for UniProtKB/Swiss-Prot for FUOM Gene

Publications for FUOM Gene

  1. Characterization and role of fucose mutarotase in mammalian cells. (PMID: 17602138) Park D. … Park C. (Glycobiology 2007) 2 3 4
  2. Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase. (PMID: 19524593) Lee K.H. … Oh B.H. (J. Mol. Biol. 2009) 3
  3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 4

Products for FUOM Gene

Sources for FUOM Gene

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