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Aliases for FUOM Gene

Aliases for FUOM Gene

  • Fucose Mutarotase 2 3 5
  • C10orf125 3 4
  • Chromosome 10 Open Reading Frame 125 2
  • Protein FucU Homolog 3
  • EC 5.1.3.29 4
  • FUCU 3
  • FucM 3

External Ids for FUOM Gene

Previous HGNC Symbols for FUOM Gene

  • C10orf125

Previous GeneCards Identifiers for FUOM Gene

  • GC10M135169

Summaries for FUOM Gene

GeneCards Summary for FUOM Gene

FUOM (Fucose Mutarotase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Synthesis of substrates in N-glycan biosythesis. GO annotations related to this gene include isomerase activity and fucose binding.

UniProtKB/Swiss-Prot for FUOM Gene

  • Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUOM Gene

Genomics for FUOM Gene

Regulatory Elements for FUOM Gene

Promoters for FUOM Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUOM on UCSC Golden Path with GeneCards custom track

Genomic Location for FUOM Gene

Chromosome:
10
Start:
133,352,775 bp from pter
End:
133,358,035 bp from pter
Size:
5,261 bases
Orientation:
Minus strand

Genomic View for FUOM Gene

Genes around FUOM on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUOM Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUOM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUOM Gene

Proteins for FUOM Gene

  • Protein details for FUOM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VDF0-FUCM_HUMAN
    Recommended name:
    Fucose mutarotase
    Protein Accession:
    A2VDF0
    Secondary Accessions:
    • A1L300
    • Q5VWY2
    • Q5VWY3
    • Q6ZPD2

    Protein attributes for FUOM Gene

    Size:
    154 amino acids
    Molecular mass:
    16765 Da
    Quaternary structure:
    • Mainly homodimer, but exists also as homotetramer, homooctamer, and homodecamer. The homodimeric form seems catalytically inactive (By similarity).
    SequenceCaution:
    • Sequence=CAH70284.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH70285.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for FUOM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUOM Gene

Proteomics data for FUOM Gene at MOPED

Post-translational modifications for FUOM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FUOM Gene

No data available for DME Specific Peptides for FUOM Gene

Domains & Families for FUOM Gene

Protein Domains for FUOM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FUOM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2VDF0

UniProtKB/Swiss-Prot:

FUCM_HUMAN :
  • Belongs to the RbsD / FucU family.
Family:
  • Belongs to the RbsD / FucU family.
genes like me logo Genes that share domains with FUOM: view

No data available for Gene Families for FUOM Gene

Function for FUOM Gene

Molecular function for FUOM Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Alpha-L-fucose = beta-L-fucose.
UniProtKB/Swiss-Prot Function:
Involved in the interconversion between alpha- and beta-L-fucoses. L-Fucose (6-deoxy-L-galactose) exists as alpha-L-fucose (29.5%) and beta-L-fucose (70.5%), the beta-form is metabolized through the salvage pathway. GDP-L-fucose formed either by the de novo or salvage pathways is transported into the endoplasmic reticulum, where it serves as a substrate for N- and O-glycosylations by fucosyltransferases. Fucosylated structures expressed on cell surfaces or secreted in biological fluids are believed to play a critical role in cell-cell adhesion and recognition processes.

Enzyme Numbers (IUBMB) for FUOM Gene

Gene Ontology (GO) - Molecular Function for FUOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016853 isomerase activity IEA --
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives ISS,TAS --
genes like me logo Genes that share ontologies with FUOM: view
genes like me logo Genes that share phenotypes with FUOM: view

Animal Models for FUOM Gene

MGI Knock Outs for FUOM:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FUOM Gene

Localization for FUOM Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUOM Gene COMPARTMENTS Subcellular localization image for FUOM gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 2
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FUOM Gene

Pathways & Interactions for FUOM Gene

genes like me logo Genes that share pathways with FUOM: view

Interacting Proteins for FUOM Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000357540%0d%0a9606.ENSP00000239690%0d%0a
Selected Interacting proteins: ENSP00000357540 for FUOM Gene via STRING

Symbol External ID(s) Details
NUDCD1

Gene Ontology (GO) - Biological Process for FUOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036065 fucosylation IEA --
genes like me logo Genes that share ontologies with FUOM: view

No data available for SIGNOR curated interactions for FUOM Gene

Drugs & Compounds for FUOM Gene

(2) Drugs for FUOM Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alpha-L-fucose Experimental Pharma 0
beta-L-fucose Experimental Pharma 0
genes like me logo Genes that share compounds with FUOM: view

Transcripts for FUOM Gene

Unigene Clusters for FUOM Gene

Fucose mutarotase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUOM Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c
SP1: - - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - - - - - -
SP5: -
SP6: - -
SP7: -

Relevant External Links for FUOM Gene

GeneLoc Exon Structure for
FUOM
ECgene alternative splicing isoforms for
FUOM

Expression for FUOM Gene

mRNA expression in normal human tissues for FUOM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUOM Gene

This gene is overexpressed in Liver (x13.6) and Kidney - Cortex (x4.5).

Protein differential expression in normal tissues from HIPED for FUOM Gene

This gene is overexpressed in Liver, secretome (33.8), Liver (15.1), and Gallbladder (12.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FUOM Gene



SOURCE GeneReport for Unigene cluster for FUOM Gene Hs.155823

genes like me logo Genes that share expression patterns with FUOM: view

Protein tissue co-expression partners for FUOM Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FUOM Gene

Orthologs for FUOM Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUOM Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FUOM 35
  • 83.78 (n)
  • 82.43 (a)
FUOM 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUOM 35
  • 84.77 (n)
  • 86.75 (a)
FUOM 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fuom 35
  • 79.61 (n)
  • 80.92 (a)
Fuom 16
Fuom 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FUOM 35
  • 99.13 (n)
  • 98.05 (a)
FUOM 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fuom 35
  • 80.7 (n)
  • 81.58 (a)
oppossum
(Monodelphis domestica)
Mammalia FUOM 36
  • 69 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii fuom 35
  • 63.04 (n)
  • 68.71 (a)
sizc217g15.3 35
fuom 36
  • 66 (a)
OneToOne
Species with no ortholog for FUOM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUOM Gene

ENSEMBL:
Gene Tree for FUOM (if available)
TreeFam:
Gene Tree for FUOM (if available)

Paralogs for FUOM Gene

No data available for Paralogs for FUOM Gene

Variants for FUOM Gene

Sequence variations from dbSNP and Humsavar for FUOM Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1057097 -- 133,355,253(-) GGGCT(C/T)TAGGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs1891371 -- 133,353,617(+) AATCC(C/T)CGCTC utr-variant-3-prime
rs1891372 -- 133,357,860(+) CCCCG(C/T)GCAAG intron-variant
rs2096169 -- 133,359,348(+) CCTGT(A/G)ATCCC upstream-variant-2KB
rs2153818 -- 133,354,448(+) CCCCT(C/G)GAGCC utr-variant-3-prime

Variation tolerance for FUOM Gene

Residual Variation Intolerance Score: 59.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.75; 15.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUOM Gene

HapMap Linkage Disequilibrium report
FUOM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FUOM Gene

Disorders for FUOM Gene

Relevant External Links for FUOM

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUOM

No disorders were found for FUOM Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUOM Gene

Publications for FUOM Gene

  1. Characterization and role of fucose mutarotase in mammalian cells. (PMID: 17602138) Park D. … Park C. (Glycobiology 2007) 2 3 4 67
  2. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3
  3. Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase. (PMID: 19524593) Lee K.H. … Oh B.H. (J. Mol. Biol. 2009) 3
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for FUOM Gene

Sources for FUOM Gene

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