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Aliases for FUNDC2 Gene

Aliases for FUNDC2 Gene

  • FUN14 Domain Containing 2 2 3 5
  • Cervical Cancer Proto-Oncogene 3 Protein 3 4
  • Hepatitis C Virus Core-Binding Protein 6 3 4
  • HCC-3 3 4
  • HCBP6 3 4
  • FUN14 Domain-Containing Protein 2 3
  • Cervical Cancer Oncogene 3 3
  • PD03104 3
  • DC44 3
  • HCC3 3

External Ids for FUNDC2 Gene

Previous GeneCards Identifiers for FUNDC2 Gene

  • GC0XP153818
  • GC0XP153908
  • GC0XP154254
  • GC0XP142800

Summaries for FUNDC2 Gene

GeneCards Summary for FUNDC2 Gene

FUNDC2 (FUN14 Domain Containing 2) is a Protein Coding gene. Diseases associated with FUNDC2 include Hepatitis C Virus. An important paralog of this gene is FUNDC1.

Gene Wiki entry for FUNDC2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUNDC2 Gene

Genomics for FUNDC2 Gene

Regulatory Elements for FUNDC2 Gene

Enhancers for FUNDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around FUNDC2 on UCSC Golden Path with GeneCards custom track

Promoters for FUNDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for FUNDC2 Gene

155,025,980 bp from pter
155,060,303 bp from pter
34,324 bases
Plus strand

Genomic View for FUNDC2 Gene

Genes around FUNDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUNDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUNDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUNDC2 Gene

Proteins for FUNDC2 Gene

  • Protein details for FUNDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FUN14 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R7W5
    • D3DWY5
    • Q8NHX8
    • Q9H2I6

    Protein attributes for FUNDC2 Gene

    189 amino acids
    Molecular mass:
    20676 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG44731.1; Type=Frameshift; Positions=69; Evidence={ECO:0000305};

neXtProt entry for FUNDC2 Gene

Post-translational modifications for FUNDC2 Gene

  • Ubiquitination at Lys 68
  • Modification sites at PhosphoSitePlus

Other Protein References for FUNDC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FUNDC2 Gene

Domains & Families for FUNDC2 Gene

Protein Domains for FUNDC2 Gene


Suggested Antigen Peptide Sequences for FUNDC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FUN14 family.
  • Belongs to the FUN14 family.
genes like me logo Genes that share domains with FUNDC2: view

No data available for Gene Families for FUNDC2 Gene

Function for FUNDC2 Gene

Phenotypes for FUNDC2 Gene

GenomeRNAi human phenotypes for FUNDC2:
genes like me logo Genes that share phenotypes with FUNDC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUNDC2 Gene

Localization for FUNDC2 Gene

Subcellular locations from

Jensen Localization Image for FUNDC2 Gene COMPARTMENTS Subcellular localization image for FUNDC2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FUNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0031307 integral component of mitochondrial outer membrane IBA --
genes like me logo Genes that share ontologies with FUNDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FUNDC2 Gene

Pathways & Interactions for FUNDC2 Gene

SuperPathways for FUNDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IBA --
genes like me logo Genes that share ontologies with FUNDC2: view

No data available for Pathways by source and SIGNOR curated interactions for FUNDC2 Gene

Drugs & Compounds for FUNDC2 Gene

No Compound Related Data Available

Transcripts for FUNDC2 Gene

Unigene Clusters for FUNDC2 Gene

FUN14 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUNDC2 Gene

No ASD Table

Relevant External Links for FUNDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUNDC2 Gene

mRNA expression in normal human tissues for FUNDC2 Gene

Protein differential expression in normal tissues from HIPED for FUNDC2 Gene

This gene is overexpressed in Nasal epithelium (43.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUNDC2 Gene

Protein tissue co-expression partners for FUNDC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUNDC2 Gene:


SOURCE GeneReport for Unigene cluster for FUNDC2 Gene:

genes like me logo Genes that share expression patterns with FUNDC2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FUNDC2 Gene

Orthologs for FUNDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUNDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FUNDC2 34
  • 88.45 (n)
  • 87.5 (a)
  • 87 (a)
(Canis familiaris)
Mammalia FUNDC2 34
  • 90.91 (n)
  • 90.91 (a)
  • 85 (a)
(Mus musculus)
Mammalia Fundc2 34
  • 88.74 (n)
  • 92.72 (a)
Fundc2 16
Fundc2 35
  • 93 (a)
(Pan troglodytes)
Mammalia FUNDC2 34
  • 99.47 (n)
  • 99.47 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia LOC365778 34
  • 82.67 (n)
  • 84.67 (a)
(Monodelphis domestica)
Mammalia FUNDC2 35
  • 82 (a)
(Ornithorhynchus anatinus)
Mammalia FUNDC2 35
  • 86 (a)
(Gallus gallus)
Aves FUNDC2 34
  • 71.08 (n)
  • 71.52 (a)
  • 57 (a)
(Anolis carolinensis)
Reptilia FUNDC2 35
  • 64 (a)
(Danio rerio)
Actinopterygii fundc2 35
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7326 35
  • 37 (a)
Species where no ortholog for FUNDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUNDC2 Gene

Gene Tree for FUNDC2 (if available)
Gene Tree for FUNDC2 (if available)

Paralogs for FUNDC2 Gene

Paralogs for FUNDC2 Gene

(1) SIMAP similar genes for FUNDC2 Gene using alignment to 3 proteins: Pseudogenes for FUNDC2 Gene

genes like me logo Genes that share paralogs with FUNDC2: view

Variants for FUNDC2 Gene

Sequence variations from dbSNP and Humsavar for FUNDC2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1048795 -- 155,054,906(+) CTTGG(C/T)CAGTC utr-variant-3-prime
rs1161925 -- 155,042,507(-) gctta(A/C/G/T)atttc intron-variant
rs1184758 -- 155,042,440(+) cctca(A/G)cctcc intron-variant
rs1185076 -- 155,042,532(-) atctg(A/C/G/T)gggtt intron-variant
rs1185500 -- 155,042,675(+) TTTTA(A/G)AAact intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUNDC2 Gene

Variant ID Type Subtype PubMed ID
esv29972 CNV gain 17803354
esv33784 CNV gain+loss 17666407
esv3559508 CNV deletion 23714750
esv3577569 CNV gain 25503493
nsv1141093 CNV deletion 24896259
nsv1151194 CNV insertion 26484159
nsv477388 CNV novel sequence insertion 20440878

Variation tolerance for FUNDC2 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUNDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUNDC2 Gene

Disorders for FUNDC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FUNDC2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitic c virus
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FUNDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FUNDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUNDC2 Gene

Publications for FUNDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. Screening and cloning gene of hepatocyte protein interacting with hepatitis C virus core protein. (PMID: 12665903) Li K. … Chen J. (Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 2002) 3 4 65
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 65
  5. HCBP6 Modulates Triglyceride Homeostasis in Hepatocytes Via the SREBP1c/FASN Pathway. (PMID: 25855506) Gao L.L. … Cheng J. (J. Cell. Biochem. 2015) 3 65

Products for FUNDC2 Gene

Sources for FUNDC2 Gene

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