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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FUNDC2 Gene

protein-coding   GIFtS: 46
GCID: GC0XP154254

FUN14 Domain Containing 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
FUN14 Domain Containing 21 2     DC442
Cervical Cancer Proto-Oncogene 3 Protein2 3     HCC32
Hepatitis C Virus Core-Binding Protein 62 3     PD031042
HCBP62 3     Cervical Cancer Oncogene 32
HCC-32 3     FUN14 Domain-Containing Protein 22

External Ids:    HGNC: 249251   Entrez Gene: 659912   Ensembl: ENSG000001657757   UniProtKB: Q9BWH23   

Export aliases for FUNDC2 gene to outside databases

Previous GC identifers: GC0XP153818 GC0XP153908 GC0XP142800


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for FUNDC2 Gene: 
FUNDC2 (FUN14 domain containing 2) is a protein-coding gene. Diseases associated with FUNDC2 include hepatitis c, and cervical cancer. An important paralog of this gene is FUNDC1.

Gene Wiki entry for FUNDC2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167198.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FUNDC2 gene promoter:
         Elk-1   C/EBPbeta   NF-1   ATF-2   NCX/Ncx   Nkx2-5   C/EBPalpha   c-Ets-1   Roaz   CRE-BP1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUNDC2 promoter sequence
   Search SABiosciences Chromatin IP Primers for FUNDC2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUNDC2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

FUNDC2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUNDC2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP154254:  view genomic region     (about GC identifiers)

Start:
154,254,255 bp from pter      End:
154,288,578 bp from pter
Size:
34,324 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FUND2_HUMAN, Q9BWH2 (See protein sequence)
Recommended Name: FUN14 domain-containing protein 2  
Size: 189 amino acids; 20676 Da
Sequence caution: Sequence=AAG44731.1; Type=Frameshift; Positions=69;
Secondary accessions: B2R7W5 D3DWY5 Q8NHX8 Q9H2I6

Explore the universe of human proteins at neXtProt for FUNDC2: NX_Q9BWH2

Explore proteomics data for FUNDC2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BWH2

  • FUNDC2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    FUNDC2 Protein Expression
    REFSEQ proteins: NP_076423.2  
    ENSEMBL proteins: 
     ENSP00000358510   ENSP00000395488  

    Human Recombinant Protein Products for FUNDC2: 
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    Cloud-Clone Corp. Proteins for FUNDC2 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--

    FUNDC2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007014 FUN14

    Graphical View of Domain Structure for InterPro Entry Q9BWH2

    ProtoNet protein and cluster: Q9BWH2

    UniProtKB/Swiss-Prot: FUND2_HUMAN, Q9BWH2
    Similarity: Belongs to the FUN14 family


    FUNDC2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for FUNDC2 
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    SwitchGear 3'UTR luciferase reporter plasmidFUNDC2 3' UTR sequence
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUNDC2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUNDC2

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/14 Interacting proteins for FUNDC2 (Q9BWH22, 3 ENSP000003585104) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL15Q9NXU52, 3MINT-64621 I2D: score=5 
    ASCC2Q9H1I82, 3MINT-65480 I2D: score=5 
    NSFP464592, 3MINT-64918 I2D: score=5 
    SAT1P216732, 3MINT-63580 I2D: score=5 
    USP13Q929952, 3MINT-65084 I2D: score=5 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for FUNDC2 (FUND2)

    Search CenterWatch for drugs/clinical trials and news about FUNDC2 / FUND2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FUNDC2 gene: 
    NM_023934.3  

    Unigene Cluster for FUNDC2:

    FUN14 domain containing 2
    Hs.356050  [show with all ESTs]
    Unigene Representative Sequence: AK091092
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475165 ENST00000369498(uc004fmw.3) ENST00000484175 ENST00000485289
    ENST00000456179 ENST00000471528 ENST00000492303
    miRNA
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    8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate FUNDC2 (see all 18):
    hsa-miR-676 hsa-miR-411 hsa-miR-485-3p hsa-miR-23a hsa-miR-3148 hsa-miR-630 hsa-miR-548c-3p hsa-miR-4280
    SwitchGear 3'UTR luciferase reporter plasmidFUNDC2 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUNDC2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUNDC2

    Additional mRNA sequence: 

    AF267862.1 AF320778.1 AJ272054.1 AK056898.1 AK091092.1 AK129832.1 AK313143.1 AY032594.1 
    BC000255.1 BC072685.1 BC108657.1 

    15 DOTS entries:

    DT.454648  DT.100030151  DT.100819935  DT.100030150  DT.75169753  DT.121312594  DT.100030149  DT.92043594 
    DT.92439185  DT.101956857  DT.121312418  DT.121312602  DT.75184711  DT.100030153  DT.91729072 

    24/351 AceView cDNA sequences (see all 351):

    BM310534 BU733045 BU070456 CD677038 AI420162 AA808601 AA128119 AA765171 
    BM310841 AA972572 BU538909 AK056898 R93970 BI856074 R94014 AI989915 
    BM713884 BC000255 AA588653 BF183063 BM553130 BM692542 BM970685 AA810681 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FUNDC2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FUNDC2 Expression
    About this image


    See FUNDC2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FUNDC2

    SOURCE GeneReport for Unigene cluster: Hs.356050
        SABiosciences Custom PCR Arrays for FUNDC2
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for FUNDC2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUNDC2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for FUNDC2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fundc21 , 5 FUN14 domain containing 21, 5 88.74(n)1
    92.72(a)1
      X (38.22 cM)5
    673911  NM_026126.41  NP_080402.31 
     753823995 
    chicken
    (Gallus gallus)
    Aves FUNDC21 FUN14 domain containing 2 71.08(n)
    71.52(a)
      422200  XM_420194.3  XP_420194.1 
    lizard
    (Anolis carolinensis)
    Reptilia FUNDC26
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343528.1(413280-413941)
    zebrafish
    (Danio rerio)
    Actinopterygii CK354984.12   -- 70.47(n)    CK354984.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG56766
    --
    26(a)
    1 → many
    2L(10254610-10255891)


    ENSEMBL Gene Tree for FUNDC2 (if available)
    TreeFam Gene Tree for FUNDC2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for FUNDC2 gene
    FUNDC12  
    1 SIMAP similar gene for FUNDC2 using alignment to 3 protein entries:     FUND2_HUMAN (see all proteins):
    FUNDC1

    FUNDC2 for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for FUNDC2
    PGOHUM00000246588 PGOHUM00000240702 PGOHUM00000243808 PGOHUM00000261001


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/362 SNPs in FUNDC2 are shown (see all 362)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1889168691,2
    --154253527(+) CTATAC/TTGATA 1 -- us2k10--------
    rs1997261831,2
    C--154253916(+) AAAAT-/AAAATA 1 -- us2k10--------
    rs1932917931,2
    --154254118(+) ATAACA/GTATTT 1 -- us2k10--------
    rs1404583001,2
    --154254553(+) AGTTAA/GCTTCA 1 -- us2k10--------
    rs1853906091,2
    --154254871(+) TCAGCC/TGTCTT 1 -- us2k10--------
    rs1894575911,2
    --154254937(+) GTCGCA/GTCAGG 1 -- us2k10--------
    rs1443165681,2
    C--154255010(+) TGGGGC/GAGAGT 1 -- us2k10--------
    rs2007566981,2
    --154255183(+) GCGCCC/GGGCCC 1 -- ut510--------
    rs1383010451,2
    C,F--154255227(+) ATCTGC/TCCCAC 2 A V mis11Minor allele frequency- T:0.00NA 2836
    rs1444281531,2
    F--154255316(+) GAGACA/CAGCTC 2 K Q mis11Minor allele frequency- C:0.00NA 3058

    HapMap Linkage Disequilibrium report for FUNDC2 (154254255 - 154288578 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FUNDC2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv29972CNV Gain17803354
    esv33784CNV Gain+Loss17666407

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    5 diseases for FUNDC2:    About MalaCards
    hepatitis c    cervical cancer    cervicitis    hepatitis
    myopia


    FUNDC2 for disorders           About GeneDecksing


    Export disorders for FUNDC2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FUNDC2 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with FUNDC2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Screening and cloning gene of hepatocyte protein interacting with hepatitis C virus core protein (PubMed id 12665903)1, 2 Li K.... Chen J. (2002)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 65991 HGNC: 24925 AceView: FUNDC2 Ensembl:ENSG00000165775 euGenes: HUgn65991
    ECgene: FUNDC2 H-InvDB: FUNDC2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FUNDC2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FUNDC2 gene:
    Search GeneIP for patents involving FUNDC2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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