FUNDC2 Gene
protein-coding GIFtS: 45
GCID: GC0XP154254
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FUN14 domain containing 2
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Aliases
for FUNDC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FUN14 Domain Containing 21 2 | | HCC-32 3 | | HCBP61 2 3 | | HCC32 | | DC441 2 | | PD031042 | | Cervical Cancer Proto-Oncogene 3 Protein2 3 | | Cervical Cancer Oncogene 32 | | Hepatitis C Virus Core-Binding Protein 62 3 | | FUN14 Domain-Containing Protein 22 |
Export aliases for FUNDC2 gene to outside databasesPrevious GC identifers: GC0XP153818 GC0XP153908 GC0XP142800 |
Summaries
for FUNDC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for FUNDC2
|
Genomic Views
for FUNDC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FUNDC2 gene promoter:
Elk-1 C/EBPbeta NF-1 ATF-2 NCX/Ncx Nkx2-5 C/EBPalpha c-Ets-1 Roaz CRE-BP1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FUNDC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUNDC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28FUNDC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP154254: view genomic region
(about GC identifiers)
Start:
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154,254,255 bp from pter |
End:
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154,288,578 bp from pter |
Size:
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34,324 bases |
Orientation:
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plus strand |
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Proteins
for FUNDC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FUND2_HUMAN, Q9BWH2 (See
protein sequence)Recommended Name: FUN14 domain-containing protein 2 Size: 189 amino acids; 20676 Da
Sequence caution: Sequence=AAG44731.1; Type=Frameshift; Positions=69;
Secondary accessions: B2R7W5 D3DWY5 Q8NHX8 Q9H2I6Explore the universe of human proteins at neXtProt for FUNDC2: NX_Q9BWH2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BWH2
FUNDC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_076423.2
ENSEMBL proteins: ENSP00000358510 ENSP00000395488
Human Recombinant Protein Products for FUNDC2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IDA | -- |
FUNDC2 for ontologies About GeneDecksing
FUNDC2 Antibody Products:
Assay Products for FUNDC2: |
Protein
Domains /
Families
for FUNDC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FUNDC2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BWH2ProtoNet protein and cluster: Q9BWH2 UniProtKB/Swiss-Prot: FUND2_HUMAN, Q9BWH2Similarity: Belongs to the FUN14 family |
Function
for FUNDC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FUNDC2 (NM_023934) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUNDC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUNDC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUNDC2 |
|
Pathways & Interactions
for FUNDC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUNDC2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/14 Interacting proteins for FUNDC2 (Q9BWH22, 3 ENSP000003585104) via UniProtKB, MINT, STRING, and/or I2D (see all 14)About this table
|
Drugs & Compounds
for FUNDC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FUNDC2
Search CenterWatch for drugs/clinical trials and news about FUNDC2 / FUND2
|
Transcripts
for FUNDC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FUNDC2 gene: NM_023934.3 Unigene Cluster for FUNDC2: FUN14 domain containing 2 Hs.356050 [show with all ESTs]Unigene Representative Sequence: AK0910927 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000475165 ENST00000369498(uc004fmw.3) ENST00000484175 ENST00000485289
ENST00000456179 ENST00000471528 ENST00000492303
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FUNDC2 (NM_023934) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUNDC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUNDC2 |
Additional cDNA sequence: AF267862.1 AF320778.1 AJ272054.1 AK056898.1 AK091092.1 AK129832.1 AK313143.1 AY032594.1 BC000255.1 BC072685.1 BC108657.1 15 DOTS entries: DT.454648 DT.100030151 DT.100819935 DT.100030150 DT.75169753 DT.121312594 DT.100030149 DT.92043594 DT.92439185 DT.101956857 DT.121312418 DT.121312602 DT.75184711 DT.100030153 DT.91729072 24/351 AceView cDNA sequences (see all 351): AA494491 BC000255 R94014 AA772764 AI989915 AA363358 BP375066 AI695529 AA765171 F35795 AY032594 BM310841 AI241025 AA126891 BU859864 BM991293 AX746776 AA808601 AK056898 AA810681 BM676502 BM697029 R93970 BM554747
GeneLoc Exon Structure
|
Expression
for FUNDC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FUNDC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See FUNDC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FUNDC2
SOURCE GeneReport for Unigene cluster: Hs.356050
SABiosciences Custom PCR Arrays for FUNDC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUNDC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FUNDC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUNDC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUNDC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUNDC2 |
Orthologs
for FUNDC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FUNDC2 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for FUNDC2 (if available)
TreeFam Gene Tree for FUNDC2 (if available) |
Paralogs
for FUNDC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FUNDC2 gene
- FUNDC12
1 SIMAP similar gene for FUNDC2 using alignment to 3 protein entries: FUND2_HUMAN (see all proteins):FUNDC1
FUNDC2 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for FUNDC2
PGOHUM00000246588 PGOHUM00000240702 PGOHUM00000243808 PGOHUM00000261001
|
Genomic Variants
for FUNDC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FUNDC2 (154254255 - 154288578 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FUNDC2
1 CNV: 23331 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUNDC2 |
|
Disorders
/ Diseases
for FUNDC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FUNDC2 for disorders About GeneDecksing
5  diseases for FUNDC2: About MalaCardscervical cancer cervicitis hepatitis c hepatitis
myopia
Export disorders for FUNDC2 gene to outside databases
|
Publications
for FUNDC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FUNDC2 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with FUNDC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Screening and cloning gene of hepatocyte protein interacting with hepatitis C virus core protein (PubMed id 12665903)1, 2 Li K.... Chen J. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Identification of novel ATP13A2 interactors and their role in a-synuclein misfolding and toxicity. (PubMed id 22645275)1 Usenovic M....Krainc D. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for FUNDC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FUNDC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FUNDC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FUNDC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FUNDC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FUNDC2 gene:
Search GeneIP for patents involving FUNDC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FUNDC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FUNDC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUNDC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUNDC2 | | | OriGene Protein Over-expression Lysate for FUNDC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FUNDC2 | | OriGene 3'-UTR Clone for FUNDC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FUNDC2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUNDC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUNDC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUNDC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUNDC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUNDC2 |
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| | | | Search Tocris compounds for FUNDC2 |
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 | | | FUNDC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUNDC2 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for FUNDC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUNDC2 |
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