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Aliases for FUNDC2 Gene

Aliases for FUNDC2 Gene

  • FUN14 Domain Containing 2 2 3 5
  • Cervical Cancer Proto-Oncogene 3 Protein 3 4
  • Hepatitis C Virus Core-Binding Protein 6 3 4
  • HCC-3 3 4
  • HCBP6 3 4
  • FUN14 Domain-Containing Protein 2 3
  • Cervical Cancer Oncogene 3 3
  • PD03104 3
  • DC44 3
  • HCC3 3

External Ids for FUNDC2 Gene

Previous GeneCards Identifiers for FUNDC2 Gene

  • GC0XP153818
  • GC0XP153908
  • GC0XP154254
  • GC0XP142800

Summaries for FUNDC2 Gene

GeneCards Summary for FUNDC2 Gene

FUNDC2 (FUN14 Domain Containing 2) is a Protein Coding gene. Diseases associated with FUNDC2 include Hepatitis C Virus. An important paralog of this gene is FUNDC1.

Gene Wiki entry for FUNDC2 Gene

Additional gene information for FUNDC2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUNDC2 Gene

Genomics for FUNDC2 Gene

Regulatory Elements for FUNDC2 Gene

Enhancers for FUNDC2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH154980 1 Ensembl ENCODE 0.3 -44.9 -44925 1 CTCF IRF2 RB1 KLF17 MAX ZIC2 THRB RAD21 CC2D1A SMC3 F8A1 FUNDC2 LOC100419792
GH0XH154988 0.9 ENCODE 0.3 -37.8 -37820 0.2 ELF3 FOXA2 NFIB ARID4B NFXL1 RAD21 RARA YY1 CREM MIXL1 FUNDC2 LOC100419792
GH0XH155007 0.6 ENCODE 0.4 -18.8 -18760 0.2 NFIC PKNOX1 NR4A1 IKZF1 DPF2 ZNF24 ZNF592 FUNDC2 LOC100419792
GH0XH155009 0.6 ENCODE 0.4 -15.8 -15835 1.8 SOX6 TAF1 TAL1 MAX NR2F2 GABPA YY1 JUND ATF3 HNF4A F8A1 FUNDC2 LOC100419792
GH0XH154967 0.5 ENCODE 0.2 -58.2 -58180 0.2 FOSL1 JUND JUN LOC100419792 FUNDC2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FUNDC2 on UCSC Golden Path with GeneCards custom track

Promoters for FUNDC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000249722 1320 2201 PKNOX1 FOXA2 ARID4B SIN3A FEZF1 YY1 ZNF766 ZNF207 FOS SP3

Genomic Locations for FUNDC2 Gene

Genomic Locations for FUNDC2 Gene
34,324 bases
Plus strand

Genomic View for FUNDC2 Gene

Genes around FUNDC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUNDC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUNDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUNDC2 Gene

Proteins for FUNDC2 Gene

  • Protein details for FUNDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FUN14 domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R7W5
    • D3DWY5
    • Q8NHX8
    • Q9H2I6

    Protein attributes for FUNDC2 Gene

    189 amino acids
    Molecular mass:
    20676 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG44731.1; Type=Frameshift; Positions=69; Evidence={ECO:0000305};

neXtProt entry for FUNDC2 Gene

Post-translational modifications for FUNDC2 Gene

  • Ubiquitination at isoforms=68
  • Modification sites at PhosphoSitePlus

Other Protein References for FUNDC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FUNDC2 Gene

Domains & Families for FUNDC2 Gene

Gene Families for FUNDC2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FUNDC2 Gene


Suggested Antigen Peptide Sequences for FUNDC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the FUN14 family.
  • Belongs to the FUN14 family.
genes like me logo Genes that share domains with FUNDC2: view

Function for FUNDC2 Gene

Phenotypes From GWAS Catalog for FUNDC2 Gene

Phenotypes for FUNDC2 Gene

GenomeRNAi human phenotypes for FUNDC2:
genes like me logo Genes that share phenotypes with FUNDC2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUNDC2 Gene

Localization for FUNDC2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUNDC2 gene
Compartment Confidence
mitochondrion 5
nucleus 5
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for FUNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IDA 20833797
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031307 integral component of mitochondrial outer membrane IBA --
genes like me logo Genes that share ontologies with FUNDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for FUNDC2 Gene

Pathways & Interactions for FUNDC2 Gene

SuperPathways for FUNDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUNDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000422 mitophagy IBA --
genes like me logo Genes that share ontologies with FUNDC2: view

No data available for Pathways by source and SIGNOR curated interactions for FUNDC2 Gene

Drugs & Compounds for FUNDC2 Gene

No Compound Related Data Available

Transcripts for FUNDC2 Gene

Unigene Clusters for FUNDC2 Gene

FUN14 domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUNDC2 Gene

No ASD Table

Relevant External Links for FUNDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUNDC2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUNDC2 Gene

Protein differential expression in normal tissues from HIPED for FUNDC2 Gene

This gene is overexpressed in Nasal epithelium (43.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUNDC2 Gene

Protein tissue co-expression partners for FUNDC2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FUNDC2 Gene:


SOURCE GeneReport for Unigene cluster for FUNDC2 Gene:


Evidence on tissue expression from TISSUES for FUNDC2 Gene

  • Nervous system(4.7)
  • Muscle(4.4)
  • Eye(4.3)
  • Liver(4.3)
  • Lymph node(4.3)
  • Spleen(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with FUNDC2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUNDC2 Gene

Orthologs for FUNDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FUNDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FUNDC2 33 34
  • 99.47 (n)
(Canis familiaris)
Mammalia FUNDC2 33 34
  • 90.91 (n)
(Mus musculus)
Mammalia Fundc2 33 16 34
  • 88.74 (n)
(Bos Taurus)
Mammalia FUNDC2 33 34
  • 88.45 (n)
(Ornithorhynchus anatinus)
Mammalia FUNDC2 34
  • 86 (a)
(Rattus norvegicus)
Mammalia LOC365778 33
  • 82.67 (n)
(Monodelphis domestica)
Mammalia FUNDC2 34
  • 82 (a)
(Gallus gallus)
Aves FUNDC2 33 34
  • 71.08 (n)
(Anolis carolinensis)
Reptilia FUNDC2 34
  • 64 (a)
(Danio rerio)
Actinopterygii fundc2 34
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7326 34
  • 37 (a)
Species where no ortholog for FUNDC2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FUNDC2 Gene

Gene Tree for FUNDC2 (if available)
Gene Tree for FUNDC2 (if available)

Paralogs for FUNDC2 Gene

Paralogs for FUNDC2 Gene

(1) SIMAP similar genes for FUNDC2 Gene using alignment to 3 proteins: Pseudogenes for FUNDC2 Gene

genes like me logo Genes that share paralogs with FUNDC2: view

Variants for FUNDC2 Gene

Sequence variations from dbSNP and Humsavar for FUNDC2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000031718 -- 155,041,659(+) ATTAA(A/G)AATGT intron-variant
rs1000044273 -- 155,030,321(+) GGGCC(A/C)GGAGT intron-variant
rs1000325240 -- 155,053,069(+) TCCCT(A/G)TGTTG intron-variant
rs1000815481 -- 155,044,221(+) GCTGC(C/T)ATATT intron-variant
rs1000930558 -- 155,055,364(+) AAAGG(C/T)TTTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for FUNDC2 Gene

Variant ID Type Subtype PubMed ID
nsv477388 CNV novel sequence insertion 20440878
nsv1151194 CNV insertion 26484159
nsv1141093 CNV deletion 24896259
esv3577569 CNV gain 25503493
esv3559508 CNV deletion 23714750
esv33784 CNV gain+loss 17666407
esv29972 CNV gain 17803354

Variation tolerance for FUNDC2 Gene

Residual Variation Intolerance Score: 39.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUNDC2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUNDC2 Gene

Disorders for FUNDC2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FUNDC2 Gene - From: GeneCards

Disorder Aliases PubMed IDs
hepatitis c virus
  • hepatitis c virus, response to therapy of
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for FUNDC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FUNDC2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUNDC2 Gene

Publications for FUNDC2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. [Screening and cloning gene of hepatocyte protein interacting with hepatitis C virus core protein]. (PMID: 12665903) Li K … Chen J (Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology 2002) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60

Products for FUNDC2 Gene

Sources for FUNDC2 Gene

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