FUNDC1 Gene
protein-coding GIFtS: 45
GCID: GC0XM044382
|
|
FUN14 domain containing 1
| |
Aliases
for FUNDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FUN14 Domain Containing 11 2 | | MGC510291 | | FUN14 Domain-Containing Protein 12 |
Export aliases for FUNDC1 gene to outside databasesPrevious GC identifers: GC0XM043429 GC0XM044139 GC0XM044267 GC0XM042105 |
Summaries
for FUNDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FUNDC1:
This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known.(provided by RefSeq, Sep 2011)
UniProtKB/Swiss-Prot: FUND1_HUMAN, Q8IVP5Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control
Gene Wiki entry for FUNDC1
|
Genomic Views
for FUNDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_079573.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FUNDC1 gene promoter:
FOXF2 ATF-2 XBP-1 CUTL1 Evi-1 CRE-BP1 RORalpha1 POU2F1 Nkx6-1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for FUNDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUNDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp11.3 Ensembl cytogenetic band: Xp11.3 HGNC cytogenetic band: Xp11.4FUNDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM044382: view genomic region
(about GC identifiers)
Start:
|
44,382,885 bp from pter |
End:
|
44,402,247 bp from pter |
Size:
|
19,363 bases |
Orientation:
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minus strand |
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Proteins
for FUNDC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FUND1_HUMAN, Q8IVP5 (See
protein sequence)Recommended Name: FUN14 domain-containing protein 1 Size: 155 amino acids; 17178 Da
Subunit: Interacts (via YXXL motif) with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP
Subcellular location: Mitochondrion outer membrane; Multi-pass membrane proteinExplore the universe of human proteins at neXtProt for FUNDC1: NX_Q8IVP5
Post-translational modifications:
Phosphorylation at Tyr-18 by SRC inhibits activation of mitophagy. Following hypoxia, dephosphorylated at Tyr-18,leading to interaction with MAP1 LC3 family proteins and triggering mitophagy1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IVP5
FUNDC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_776155.1
ENSEMBL proteins: ENSP00000367284
Human Recombinant Protein Products for FUNDC1:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005741 | mitochondrial outer membrane |
IDA | -- | | GO:0031307 | integral to mitochondrial outer membrane |
IDA | -- |
FUNDC1 for ontologies About GeneDecksing
FUNDC1 Antibody Products:
Assay Products for FUNDC1: |
Protein
Domains /
Families
for FUNDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FUNDC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IVP5ProtoNet protein and cluster: Q8IVP5 UniProtKB/Swiss-Prot: FUND1_HUMAN, Q8IVP5Domain: The YXXL motif mediates the interaction with MAP1 LC3 family proteins MAP1LC3A, MAP1LC3B and GABARAP(PubMed:22267086)Similarity: Belongs to the FUN14 family |
Function
for FUNDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: FUND1_HUMAN, Q8IVP5Function: Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
FUNDC1 for ontologies About GeneDecksing
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC1
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUNDC1 |
|
Pathways & Interactions
for FUNDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUNDC1
2 Interacting proteins for FUNDC1 (Q8IVP53) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000422 | mitochondrion degradation |
IMP | -- | | GO:0001666 | response to hypoxia |
IMP | -- |
FUNDC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for FUNDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FUNDC1
Search CenterWatch for drugs/clinical trials and news about FUNDC1 / FUND1
|
Transcripts
for FUNDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FUNDC1 gene: NM_173794.3 Unigene Cluster for FUNDC1: FUN14 domain containing 1 Hs.7549 [show with all ESTs]Unigene Representative Sequence: NM_1737942 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378045(uc004dgc.3) ENST00000483115
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUNDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FUNDC1 (NM_173794) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUNDC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUNDC1 |
Additional cDNA sequence: BC035015.2 BC042813.1 2 DOTS entries: DT.40200969 DT.97861583 24/34 AceView cDNA sequences (see all 34): BX282441 BM837991 BQ220222 BP871219 T25867 AI571940 CB118016 BF033615 BQ632035 NM_173794 BQ631739 BU959085 BC035015 BI548142 BM461507 BI598082 AI636066 BI256389 BI552210 BC042813 CD389571 BI596548 AW515133 BG700106
GeneLoc Exon Structure
|
Expression
for FUNDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FUNDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATAGTTTC
About this image
See FUNDC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FUNDC1
SOURCE GeneReport for Unigene cluster: Hs.7549
UniProtKB/Swiss-Prot: FUND1_HUMAN, Q8IVP5Tissue specificity: Widely expressed
SABiosciences Custom PCR Arrays for FUNDC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUNDC1
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUNDC1 |
Orthologs
for FUNDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FUNDC1 gene from 5/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FUNDC11 |
FUN14 domain containing 1 |
84.3(n)
88.39(a) |
|
418558 XM_416763.3 XP_416763.2 |
lizard
(Anolis carolinensis) |
Reptilia |
FUNDC16 |
-- |
89(a) |
1 ↔ 1 |
3(135490087-135505260) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.259942 |
Xenopus laevis transcribed sequence with weak similarity more |
80.67(n) |
|
CA973114.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
fundc11 |
FUN14 domain containing 1 |
73.47(n)
74.83(a) |
|
436984 NM_001002711.2 NP_001002711.2 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG56766 |
-- |
23(a) |
1 → many |
2L(10254610-10255891) |
ENSEMBL Gene Tree for FUNDC1 (if available)
TreeFam Gene Tree for FUNDC1 (if available) |
Paralogs
for FUNDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FUNDC1 gene
- FUNDC22
1 SIMAP similar gene for FUNDC1 using alignment to 1 protein entry: FUND1_HUMAN:FUNDC2
FUNDC1 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for FUNDC1
PGOHUM00000242515 PGOHUM00000243471
|
Genomic Variants
for FUNDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FUNDC1 (44382885 - 44402247 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FUNDC1
1 CNV: 53000
1 Indel: 47812
Locus Specific Mutation Databases (LSDB): FUNDC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUNDC1 |
|
Disorders
/ Diseases
for FUNDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FUNDC1 for disorders About GeneDecksing
OMIM gene information: 300871
OMIM disorders: --
1  disease for FUNDC1: About MalaCardshypoxia
Export disorders for FUNDC1 gene to outside databases
|
Publications
for FUNDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FUNDC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FUNDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells. (PubMed id 22267086)1, 2 Liu L.... Chen Q. (2012)
- The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Genome-wide association scan for five major dimensions of personality. (PubMed id 18957941)1 Terracciano A....Costa P.T. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Creation of genome-wide protein expression libraries using random activation of gene expression. (PubMed id 11329013)1 Harrington J.J.... Ducar M. (2001)
|
External Searches for FUNDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FUNDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FUNDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FUNDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FUNDC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FUNDC1 gene:
Search GeneIP for patents involving FUNDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FUNDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUNDC1 |
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