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Aliases for FUK Gene

Aliases for FUK Gene

  • Fucokinase 2 3 4 5
  • L-Fucose Kinase 2
  • 1110046B12Rik 3
  • EC 2.7.1.52 4

External Ids for FUK Gene

Previous GeneCards Identifiers for FUK Gene

  • GC16P061190
  • GC16P070908
  • GC16P070223
  • GC16P070264
  • GC16P069045
  • GC16P056320

Summaries for FUK Gene

Entrez Gene Summary for FUK Gene

  • The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUK Gene

FUK (Fucokinase) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor.

UniProtKB/Swiss-Prot for FUK Gene

  • Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUK Gene

Genomics for FUK Gene

Regulatory Elements for FUK Gene

Enhancers for FUK Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FUK on UCSC Golden Path with GeneCards custom track

Promoters for FUK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUK on UCSC Golden Path with GeneCards custom track

Genomic Location for FUK Gene

Chromosome:
16
Start:
70,454,421 bp from pter
End:
70,480,274 bp from pter
Size:
25,854 bases
Orientation:
Plus strand

Genomic View for FUK Gene

Genes around FUK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUK Gene

Proteins for FUK Gene

  • Protein details for FUK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0W3-FUK_HUMAN
    Recommended name:
    L-fucose kinase
    Protein Accession:
    Q8N0W3
    Secondary Accessions:
    • Q5PSM3
    • Q5XKL6
    • Q6ZRA0
    • Q96MT9

    Protein attributes for FUK Gene

    Size:
    1084 amino acids
    Molecular mass:
    117623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71190.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305}; Sequence=CAD29647.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305};

    Alternative splice isoforms for FUK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUK Gene

Proteomics data for FUK Gene at MOPED

Post-translational modifications for FUK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FUK Gene

Domains & Families for FUK Gene

Suggested Antigen Peptide Sequences for FUK Gene

Graphical View of Domain Structure for InterPro Entry

Q8N0W3

UniProtKB/Swiss-Prot:

FUK_HUMAN :
  • Belongs to the GHMP kinase family.
Family:
  • Belongs to the GHMP kinase family.
genes like me logo Genes that share domains with FUK: view

No data available for Gene Families for FUK Gene

Function for FUK Gene

Molecular function for FUK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.
UniProtKB/Swiss-Prot Function:
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Enzyme Numbers (IUBMB) for FUK Gene

Gene Ontology (GO) - Molecular Function for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050201 fucokinase activity NAS,TAS --
genes like me logo Genes that share ontologies with FUK: view
genes like me logo Genes that share phenotypes with FUK: view

Animal Model Products

  • Taconic Biosciences Mouse Models for FUK

miRNA for FUK Gene

miRTarBase miRNAs that target FUK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUK Gene

Localization for FUK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUK Gene COMPARTMENTS Subcellular localization image for FUK gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FUK Gene

Pathways & Interactions for FUK Gene

genes like me logo Genes that share pathways with FUK: view

Interacting Proteins for FUK Gene

Gene Ontology (GO) - Biological Process for FUK Gene

None

No data available for SIGNOR curated interactions for FUK Gene

Drugs & Compounds for FUK Gene

(1) Drugs for FUK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(3) Additional Compounds for FUK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Fucose 1-phosphate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonic acid
  • 6-Deoxy-L-Galactopyranose 1-(dihydrogen phosphate)
  • 6-Deoxy-L-galactose 1-phosphate
  • b-L-Fucose 1-phosphate
16562-58-6
l-fucose
  • (-)-Fucose
  • (-)-L-Fucose
  • 6-Deoxy-beta-galactose
  • 6-Deoxy-D-galactopyranose
  • 6-Deoxy-delta-galactopyranose
2438-80-4
genes like me logo Genes that share compounds with FUK: view

Transcripts for FUK Gene

Unigene Clusters for FUK Gene

Fucokinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - -
SP6: -
SP7: - - - - -
SP8:
SP9:
SP10:

ExUns: 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for FUK Gene

GeneLoc Exon Structure for
FUK
ECgene alternative splicing isoforms for
FUK

Expression for FUK Gene

mRNA expression in normal human tissues for FUK Gene

Protein differential expression in normal tissues from HIPED for FUK Gene

This gene is overexpressed in Heart (19.2) and Stomach (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUK Gene



SOURCE GeneReport for Unigene cluster for FUK Gene Hs.7907

genes like me logo Genes that share expression patterns with FUK: view

Protein tissue co-expression partners for FUK Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FUK Gene

Orthologs for FUK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FUK Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FUK 35
  • 86.47 (n)
  • 87.49 (a)
FUK 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUK 35
  • 88.26 (n)
  • 89.9 (a)
FUK 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fuk 35
  • 84.62 (n)
  • 85.61 (a)
Fuk 16
Fuk 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FUK 35
  • 99.08 (n)
  • 99.17 (a)
FUK 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fuk 35
  • 83.69 (n)
  • 84.33 (a)
oppossum
(Monodelphis domestica)
Mammalia FUK 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUK 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUK 35
  • 68.46 (n)
  • 65.6 (a)
FUK 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUK 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fuk 35
  • 60.21 (n)
  • 59.92 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100150934 35
  • 58.79 (n)
  • 57.9 (a)
wufa03b12 35
FUK 36
  • 56 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C26D10.4 35
  • 40.48 (n)
  • 32.91 (a)
C26D10.4 36
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons FKGP 35
  • 38.91 (n)
  • 29.7 (a)
rice
(Oryza sativa)
Liliopsida Os03g0115100 35
  • 41 (n)
  • 31.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for FUK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUK Gene

ENSEMBL:
Gene Tree for FUK (if available)
TreeFam:
Gene Tree for FUK (if available)

Paralogs for FUK Gene

(1) SIMAP similar genes for FUK Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FUK: view

No data available for Paralogs for FUK Gene

Variants for FUK Gene

Sequence variations from dbSNP and Humsavar for FUK Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs17881323 - 70,466,906(+) CAGGC(A/C/G)TGTGG upstream-variant-2KB, reference, missense
rs17881069 - 70,473,137(+) TGCGA(A/C/G)CCTGG reference, missense
rs17886171 - 70,473,288(+) CCTGC(A/G/T)CCCGC reference, missense
rs17883716 - 70,474,641(+) ACTGC(C/T)GGGAC reference, synonymous-codon, missense
rs17884050 - 70,475,698(+) GAGCC(A/G)CAGGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FUK Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833272 CNV Loss 17160897
nsv906873 CNV Loss 21882294

Variation tolerance for FUK Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FUK Gene

Disorders for FUK Gene

Relevant External Links for FUK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUK

No disorders were found for FUK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUK Gene

Publications for FUK Gene

  1. Identification of human L-fucose kinase amino acid sequence. (PMID: 12056818) Hinderlich S. … Bauer C. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for FUK Gene

Sources for FUK Gene

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