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Aliases for FUK Gene

Aliases for FUK Gene

  • Fucokinase 2 3 4 5
  • L-Fucose Kinase 2 3
  • 1110046B12Rik 3
  • EC 2.7.1.52 4

External Ids for FUK Gene

Previous GeneCards Identifiers for FUK Gene

  • GC16P061190
  • GC16P070908
  • GC16P070223
  • GC16P070264
  • GC16P069045
  • GC16P056320

Summaries for FUK Gene

Entrez Gene Summary for FUK Gene

  • The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUK Gene

FUK (Fucokinase) is a Protein Coding gene. Among its related pathways are Amino sugar and nucleotide sugar metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor.

UniProtKB/Swiss-Prot for FUK Gene

  • Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Additional gene information for FUK Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUK Gene

Genomics for FUK Gene

Regulatory Elements for FUK Gene

Enhancers for FUK Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H070414 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -35.2 -35166 10.3 HDGF PKNOX1 ATF1 ARNT ARID4B TCF12 ZNF121 ZNF766 GATA2 ATF7 FUK COG4 RPS27P26 RNU6-23P LOC100506083 AARS DDX19B SMG1P7 PDXDC2P-NPIPB14P WWP2
GH16H069479 1.6 FANTOM5 Ensembl ENCODE dbSUPER 15.3 -973.1 -973097 4 HDAC1 ZNF133 KLF17 FEZF1 BATF RAD21 TCF12 KLF7 FOS EGR2 NFAT5 CYB5B FUK NPIPB14P PDXDC2P-NPIPB14P LOC400541 MIR1538 PDXDC2P EXOSC6 PDPR
GH16H070986 1.3 Ensembl ENCODE 18.3 +533.0 533041 1.1 PKNOX1 ZNF133 GLI4 ZNF2 FOS SP3 YY2 REST TSHZ1 ZNF518A SF3B3 PDPR PDXDC2P-NPIPB14P DDX19A LOC400541 EXOSC6 HYDIN DDX19B NPIPB14P PDXDC2P
GH16H070436 1.4 ENCODE dbSUPER 15.8 -16.3 -16281 3.9 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 SLC30A9 SMG1P7 DDX19B COG4 CLEC18A PDXDC2P-NPIPB14P SF3B3 NFAT5 NONOP1 FUK PDXDC2P
GH16H070711 1.8 FANTOM5 Ensembl ENCODE dbSUPER 11.6 +260.0 260032 6 PKNOX1 FOXA2 MLX ARID4B DMAP1 YY1 SLC30A9 ZNF143 FOS MXD4 ZNF19 ZNF23 VAC14-AS1 FUK NPIPB14P EXOSC6 VAC14 PDXDC2P ENSG00000279412 PIR61375
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FUK on UCSC Golden Path with GeneCards custom track

Promoters for FUK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000087568 279 1801 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 ZNF766

Genomic Locations for FUK Gene

Genomic Locations for FUK Gene
chr16:70,454,421-70,480,274
(GRCh38/hg38)
Size:
25,854 bases
Orientation:
Plus strand
chr16:70,488,324-70,514,177
(GRCh37/hg19)

Genomic View for FUK Gene

Genes around FUK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUK Gene

Proteins for FUK Gene

  • Protein details for FUK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0W3-FUK_HUMAN
    Recommended name:
    L-fucose kinase
    Protein Accession:
    Q8N0W3
    Secondary Accessions:
    • Q5PSM3
    • Q5XKL6
    • Q6ZRA0
    • Q96MT9

    Protein attributes for FUK Gene

    Size:
    1084 amino acids
    Molecular mass:
    117623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71190.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305}; Sequence=CAD29647.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305};

    Alternative splice isoforms for FUK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUK Gene

Post-translational modifications for FUK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FUK Gene

Domains & Families for FUK Gene

Gene Families for FUK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FUK Gene

Graphical View of Domain Structure for InterPro Entry

Q8N0W3

UniProtKB/Swiss-Prot:

FUK_HUMAN :
  • Belongs to the GHMP kinase family.
Family:
  • Belongs to the GHMP kinase family.
genes like me logo Genes that share domains with FUK: view

Function for FUK Gene

Molecular function for FUK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.
UniProtKB/Swiss-Prot Function:
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Enzyme Numbers (IUBMB) for FUK Gene

Phenotypes From GWAS Catalog for FUK Gene

Gene Ontology (GO) - Molecular Function for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
GO:0050201 fucokinase activity TAS --
genes like me logo Genes that share ontologies with FUK: view
genes like me logo Genes that share phenotypes with FUK: view

miRNA for FUK Gene

miRTarBase miRNAs that target FUK

Clone Products

  • Addgene plasmids for FUK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUK Gene

Localization for FUK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUK gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FUK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FUK Gene

Pathways & Interactions for FUK Gene

genes like me logo Genes that share pathways with FUK: view

Gene Ontology (GO) - Biological Process for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0042352 GDP-L-fucose salvage IBA --
GO:0046835 carbohydrate phosphorylation IEA --
genes like me logo Genes that share ontologies with FUK: view

No data available for SIGNOR curated interactions for FUK Gene

Drugs & Compounds for FUK Gene

(1) Drugs for FUK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0

(3) Additional Compounds for FUK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Fucose 1-phosphate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonic acid
  • 6-Deoxy-L-Galactopyranose 1-(dihydrogen phosphate)
  • 6-Deoxy-L-galactose 1-phosphate
  • b-L-Fucose 1-phosphate
16562-58-6
l-fucose
  • (-)-Fucose
  • (-)-L-Fucose
  • 6-Deoxy-beta-galactose
  • 6-Deoxy-D-galactopyranose
  • 6-Deoxy-delta-galactopyranose
2438-80-4
genes like me logo Genes that share compounds with FUK: view

Transcripts for FUK Gene

Unigene Clusters for FUK Gene

Fucokinase:
Representative Sequences:

Clone Products

  • Addgene plasmids for FUK

Alternative Splicing Database (ASD) splice patterns (SP) for FUK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - -
SP6: -
SP7: - - - - -
SP8:
SP9:
SP10:

ExUns: 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for FUK Gene

GeneLoc Exon Structure for
FUK
ECgene alternative splicing isoforms for
FUK

Expression for FUK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUK Gene

Protein differential expression in normal tissues from HIPED for FUK Gene

This gene is overexpressed in Heart (19.2) and Stomach (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUK Gene



Protein tissue co-expression partners for FUK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FUK Gene:

FUK

SOURCE GeneReport for Unigene cluster for FUK Gene:

Hs.7907

Evidence on tissue expression from TISSUES for FUK Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with FUK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUK Gene

Orthologs for FUK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FUK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUK 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia FUK 33 34
  • 88.26 (n)
cow
(Bos Taurus)
Mammalia FUK 33 34
  • 86.47 (n)
mouse
(Mus musculus)
Mammalia Fuk 33 16 34
  • 84.62 (n)
rat
(Rattus norvegicus)
Mammalia Fuk 33
  • 83.69 (n)
oppossum
(Monodelphis domestica)
Mammalia FUK 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUK 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUK 33 34
  • 68.46 (n)
lizard
(Anolis carolinensis)
Reptilia FUK 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fuk 33
  • 60.21 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100150934 33
  • 58.79 (n)
FUK 34
  • 56 (a)
OneToOne
wufa03b12 33
worm
(Caenorhabditis elegans)
Secernentea C26D10.4 33 34
  • 40.48 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons FKGP 33
  • 38.91 (n)
rice
(Oryza sativa)
Liliopsida Os03g0115100 33
  • 41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToOne
Species where no ortholog for FUK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUK Gene

ENSEMBL:
Gene Tree for FUK (if available)
TreeFam:
Gene Tree for FUK (if available)

Paralogs for FUK Gene

(1) SIMAP similar genes for FUK Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FUK: view

No data available for Paralogs for FUK Gene

Variants for FUK Gene

Sequence variations from dbSNP and Humsavar for FUK Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs78726068 Likely benign 70,480,603(+) TCATA(A/C)ACATC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000001487 -- 70,480,009(+) TATGG(C/T)TGGGA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000213695 -- 70,477,673(+) TCCTC(C/T)GACTA intron-variant, nc-transcript-variant
rs1000321456 -- 70,468,697(+) AAGCC(C/T)GGAGT intron-variant
rs1000378653 -- 70,473,763(+) TGAAC(C/T)TCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUK Gene

Variant ID Type Subtype PubMed ID
nsv833272 CNV loss 17160897
nsv7285 OTHER inversion 18451855
esv3892881 CNV gain 25118596

Variation tolerance for FUK Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUK Gene

Disorders for FUK Gene

Relevant External Links for FUK

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUK

No disorders were found for FUK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUK Gene

Publications for FUK Gene

  1. Identification of human L-fucose kinase amino acid sequence. (PMID: 12056818) Hinderlich S … Bauer C (Biochemical and biophysical research communications 2002) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for FUK Gene

  • Addgene plasmids for FUK

Sources for FUK Gene

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