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Aliases for FUK Gene

Aliases for FUK Gene

  • Fucokinase 2 3 4 5
  • L-Fucose Kinase 2 3
  • 1110046B12Rik 3
  • EC 2.7.1.52 4

External Ids for FUK Gene

Previous GeneCards Identifiers for FUK Gene

  • GC16P061190
  • GC16P070908
  • GC16P070223
  • GC16P070264
  • GC16P069045
  • GC16P056320

Summaries for FUK Gene

Entrez Gene Summary for FUK Gene

  • The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUK Gene

FUK (Fucokinase) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and phosphotransferase activity, alcohol group as acceptor.

UniProtKB/Swiss-Prot for FUK Gene

  • Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Additional gene information for FUK Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUK Gene

Genomics for FUK Gene

GeneHancer (GH) Regulatory Elements for FUK Gene

Promoters and enhancers for FUK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I070453 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.7 694 3.3 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 FUK SMG1P7 COG4 LOC100506083 PDXDC2P-NPIPB14P NPIPB14P
GH16I070414 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 29 -35.2 -35165 10.3 HDGF PKNOX1 FOXA2 ARNT ARID4B ZNF766 SP5 ZC3H11A REST ZNF592 LOC105371329 FUK COG4 DDX19B PDXDC2P-NPIPB14P SF3B3 NONOP1 NPIPB14P NFAT5 PDPR
GH16I071287 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 15.3 +834.7 834702 2.5 HDGF PKNOX1 CLOCK FOXA2 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 CMTR2 LOC102723786 SF3B3 ZNF19 IST1 FUK HYDIN ZNF23 AP1G1 DHX38
GH16I069563 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 -887.9 -887908 7 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B NEUROD1 SIN3A NFAT5 MIR1538 NPIPB14P PDXDC2P-NPIPB14P PDXDC2P SF3B3 PDPR EXOSC6 LOC400541 NONOP1
GH16I070530 Enhancer 0.7 FANTOM5 35.7 +75.8 75841 0.1 ZFP64 ZNF140 ZNF223 ZNF697 ZNF354C SCRT2 ZNF202 ZNF680 ZBTB11 ZC3H11A SNORD111B GC16P070529 PDPR LOC400541 SF3B3 PDXDC2P-NPIPB14P NPIPB14P FUK NONOP1 PDXDC2P
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FUK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUK gene promoter:

Genomic Locations for FUK Gene

Genomic Locations for FUK Gene
chr16:70,454,421-70,480,274
(GRCh38/hg38)
Size:
25,854 bases
Orientation:
Plus strand
chr16:70,488,324-70,514,177
(GRCh37/hg19)

Genomic View for FUK Gene

Genes around FUK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUK Gene

Proteins for FUK Gene

  • Protein details for FUK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0W3-FUK_HUMAN
    Recommended name:
    L-fucose kinase
    Protein Accession:
    Q8N0W3
    Secondary Accessions:
    • Q5PSM3
    • Q5XKL6
    • Q6ZRA0
    • Q96MT9

    Protein attributes for FUK Gene

    Size:
    1084 amino acids
    Molecular mass:
    117623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71190.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305}; Sequence=CAD29647.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305};

    Alternative splice isoforms for FUK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUK Gene

Post-translational modifications for FUK Gene

No Post-translational modifications

No data available for DME Specific Peptides for FUK Gene

Domains & Families for FUK Gene

Gene Families for FUK Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FUK Gene

Graphical View of Domain Structure for InterPro Entry

Q8N0W3

UniProtKB/Swiss-Prot:

FUK_HUMAN :
  • Belongs to the GHMP kinase family.
Family:
  • Belongs to the GHMP kinase family.
genes like me logo Genes that share domains with FUK: view

Function for FUK Gene

Molecular function for FUK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-fucose = ADP + beta-L-fucose 1-phosphate.
UniProtKB/Swiss-Prot Function:
Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides.

Enzyme Numbers (IUBMB) for FUK Gene

Phenotypes From GWAS Catalog for FUK Gene

Gene Ontology (GO) - Molecular Function for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
GO:0050201 fucokinase activity TAS --
genes like me logo Genes that share ontologies with FUK: view
genes like me logo Genes that share phenotypes with FUK: view

miRNA for FUK Gene

miRTarBase miRNAs that target FUK

Clone Products

  • Addgene plasmids for FUK

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUK Gene

Localization for FUK Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUK gene
Compartment Confidence
cytosol 5
mitochondrion 2
nucleus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FUK: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FUK Gene

Pathways & Interactions for FUK Gene

genes like me logo Genes that share pathways with FUK: view

Gene Ontology (GO) - Biological Process for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016310 phosphorylation IEA --
GO:0042352 GDP-L-fucose salvage IBA --
GO:0046835 carbohydrate phosphorylation IEA --
genes like me logo Genes that share ontologies with FUK: view

No data available for SIGNOR curated interactions for FUK Gene

Drugs & Compounds for FUK Gene

(1) Drugs for FUK Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Investigational Nutra Agonist 0

(3) Additional Compounds for FUK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Fucose 1-phosphate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonic acid
  • 6-Deoxy-L-Galactopyranose 1-(dihydrogen phosphate)
  • 6-Deoxy-L-galactose 1-phosphate
  • b-L-Fucose 1-phosphate
16562-58-6
l-fucose
  • (-)-Fucose
  • (-)-L-Fucose
  • 6-Deoxy-beta-galactose
  • 6-Deoxy-D-galactopyranose
  • 6-Deoxy-delta-galactopyranose
2438-80-4
genes like me logo Genes that share compounds with FUK: view

Transcripts for FUK Gene

Unigene Clusters for FUK Gene

Fucokinase:
Representative Sequences:

Clone Products

  • Addgene plasmids for FUK

Alternative Splicing Database (ASD) splice patterns (SP) for FUK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - -
SP6: -
SP7: - - - - -
SP8:
SP9:
SP10:

ExUns: 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for FUK Gene

GeneLoc Exon Structure for
FUK
ECgene alternative splicing isoforms for
FUK

Expression for FUK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUK Gene

Protein differential expression in normal tissues from HIPED for FUK Gene

This gene is overexpressed in Heart (19.2) and Stomach (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUK Gene



Protein tissue co-expression partners for FUK Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FUK Gene:

FUK

SOURCE GeneReport for Unigene cluster for FUK Gene:

Hs.7907

Evidence on tissue expression from TISSUES for FUK Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with FUK: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUK Gene

Orthologs for FUK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FUK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUK 33 34
  • 99.08 (n)
dog
(Canis familiaris)
Mammalia FUK 33 34
  • 88.26 (n)
cow
(Bos Taurus)
Mammalia FUK 33 34
  • 86.47 (n)
mouse
(Mus musculus)
Mammalia Fuk 33 16 34
  • 84.62 (n)
rat
(Rattus norvegicus)
Mammalia Fuk 33
  • 83.69 (n)
oppossum
(Monodelphis domestica)
Mammalia FUK 34
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUK 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUK 33 34
  • 68.46 (n)
lizard
(Anolis carolinensis)
Reptilia FUK 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fuk 33
  • 60.21 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100150934 33
  • 58.79 (n)
FUK 34
  • 56 (a)
OneToOne
wufa03b12 33
worm
(Caenorhabditis elegans)
Secernentea C26D10.4 33 34
  • 40.48 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons FKGP 33
  • 38.91 (n)
rice
(Oryza sativa)
Liliopsida Os03g0115100 33
  • 41 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 42 (a)
OneToOne
Species where no ortholog for FUK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUK Gene

ENSEMBL:
Gene Tree for FUK (if available)
TreeFam:
Gene Tree for FUK (if available)

Paralogs for FUK Gene

(1) SIMAP similar genes for FUK Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FUK: view

No data available for Paralogs for FUK Gene

Variants for FUK Gene

Sequence variations from dbSNP and Humsavar for FUK Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs78726068 likely-benign, Congenital disorder of glycosylation 70,480,603(+) A/C downstream_transcript_variant
rs1000001487 -- 70,480,009(+) C/T 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000213695 -- 70,477,673(+) T/C intron_variant, non_coding_transcript_variant
rs1000321456 -- 70,468,697(+) T/C intron_variant
rs1000378653 -- 70,473,763(+) C/G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FUK Gene

Variant ID Type Subtype PubMed ID
esv3892881 CNV gain 25118596
nsv7285 OTHER inversion 18451855
nsv833272 CNV loss 17160897

Variation tolerance for FUK Gene

Residual Variation Intolerance Score: 97.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.86; 67.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUK Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUK Gene

Disorders for FUK Gene

No disorders were found for FUK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUK Gene

Publications for FUK Gene

  1. Identification of human L-fucose kinase amino acid sequence. (PMID: 12056818) Hinderlich S … Bauer C (Biochemical and biophysical research communications 2002) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for FUK Gene

Sources for FUK Gene

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