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Aliases for FUK Gene

Aliases for FUK Gene

  • Fucokinase 2 3 4
  • L-Fucose Kinase 2 3
  • 1110046B12Rik 3
  • EC 2.7.1.52 4

External Ids for FUK Gene

Summaries for FUK Gene

Entrez Gene Summary for FUK Gene

  • The protein encoded by this gene belongs to the GHMP (galacto-, homoserine, mevalonate and phosphomevalonate) kinase family and catalyzes the phosphorylation of L-fucose to form beta-L-fucose 1-phosphate. This enzyme catalyzes the first step in the utilization of free L-fucose in glycoprotein and glycolipid synthesis. L-fucose may be important in mediating a number of cell-cell interactions such as blood group antigen recognition, inflammation, and metastatis. While several transcript variants may exist for this gene, the full-length nature of only one has been described to date. [provided by RefSeq, Jul 2008]

GeneCards Summary for FUK Gene

FUK (Fucokinase) is a Protein Coding gene. Among its related pathways are Metabolism and Amino sugar and nucleotide sugar metabolism. GO annotations related to this gene include fucokinase activity.

UniProtKB/Swiss-Prot for FUK Gene

  • Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUK Gene

Genomics for FUK Gene

Genomic Location for FUK Gene

Start:
70,454,421 bp from pter
End:
70,480,274 bp from pter
Size:
25,854 bases
Orientation:
Plus strand

Genomic View for FUK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUK Gene

Regulatory Elements for FUK Gene

Proteins for FUK Gene

  • Protein details for FUK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N0W3-FUK_HUMAN
    Recommended name:
    L-fucose kinase
    Protein Accession:
    Q8N0W3
    Secondary Accessions:
    • Q5PSM3
    • Q5XKL6
    • Q6ZRA0
    • Q96MT9

    Protein attributes for FUK Gene

    Size:
    1084 amino acids
    Molecular mass:
    117623 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB71190.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305}; Sequence=CAD29647.1; Type=Frameshift; Positions=19; Evidence={ECO:0000305};

    Alternative splice isoforms for FUK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUK Gene

Proteomics data for FUK Gene at MOPED

Post-translational modifications for FUK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FUK Gene

Domains for FUK Gene

UniProtKB/Swiss-Prot:

FUK_HUMAN
Family:
  • Belongs to the GHMP kinase family.:
    • Q8N0W3
genes like me logo Genes that share domains with FUK: view

No data available for Gene Families for FUK Gene

Function for FUK Gene

Molecular function for FUK Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-fucose = ADP + beta-L-fucose 1-phosphate
UniProtKB/Swiss-Prot Function: Takes part in the salvage pathway for reutilization of fucose from the degradation of oligosaccharides

Enzyme Numbers (IUBMB) for FUK Gene

Gene Ontology (GO) - Molecular Function for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
GO:0016773 phosphotransferase activity, alcohol group as acceptor --
GO:0050201 fucokinase activity NAS 12056818
genes like me logo Genes that share ontologies with FUK: view

Phenotypes for FUK Gene

GenomeRNAi human phenotypes for FUK:
genes like me logo Genes that share phenotypes with FUK: view

miRNA for FUK Gene

miRTarBase miRNAs that target FUK

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for FUK Gene

Localization for FUK Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUK Gene COMPARTMENTS Subcellular localization image for FUK gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FUK: view

Pathways for FUK Gene

genes like me logo Genes that share pathways with FUK: view

Pathways by source for FUK Gene

Interacting Proteins for FUK Gene

Gene Ontology (GO) - Biological Process for FUK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with FUK: view

Compounds for FUK Gene

(4) HMDB Compounds for FUK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Fucose 1-phosphate
  • (3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl)oxyphosphonate
16562-58-6
L-Fucose
  • (-)-Fucose
2438-80-4
genes like me logo Genes that share compounds with FUK: view

Transcripts for FUK Gene

Unigene Clusters for FUK Gene

Fucokinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUK Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b ^
SP1: - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - - - - - - -
SP5: - -
SP6: -
SP7: - - - - -
SP8:
SP9:
SP10:

ExUns: 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24a · 24b ^ 25
SP1: - - - -
SP2: - - -
SP3: - -
SP4: - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for FUK Gene

GeneLoc Exon Structure for
FUK
ECgene alternative splicing isoforms for
FUK

Expression for FUK Gene

mRNA expression in normal human tissues for FUK Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUK Gene

SOURCE GeneReport for Unigene cluster for FUK Gene Hs.7907

genes like me logo Genes that share expressions with FUK: view

Orthologs for FUK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FUK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUK 36
  • 99.08 (n)
  • 99.17 (a)
FUK 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUK 36
  • 86.47 (n)
  • 87.49 (a)
FUK 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUK 36
  • 88.26 (n)
  • 89.9 (a)
FUK 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fuk 36
  • 84.62 (n)
  • 85.61 (a)
Fuk 16
Fuk 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUK 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUK 37
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fuk 36
  • 83.69 (n)
  • 84.33 (a)
chicken
(Gallus gallus)
Aves FUK 36
  • 68.46 (n)
  • 65.6 (a)
FUK 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUK 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fuk 36
  • 60.21 (n)
  • 59.92 (a)
zebrafish
(Danio rerio)
Actinopterygii FUK 37
  • 56 (a)
OneToOne
LOC100150934 36
  • 58.79 (n)
  • 57.9 (a)
wufa03b12 36
worm
(Caenorhabditis elegans)
Secernentea C26D10.4 36
  • 40.48 (n)
  • 32.91 (a)
C26D10.4 37
  • 27 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons FKGP 36
  • 38.91 (n)
  • 29.7 (a)
rice
(Oryza sativa)
Liliopsida Os03g0115100 36
  • 41 (n)
  • 31.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToOne
Species with no ortholog for FUK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUK Gene

ENSEMBL:
Gene Tree for FUK (if available)
TreeFam:
Gene Tree for FUK (if available)

Paralogs for FUK Gene

Selected SIMAP similar genes for FUK Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FUK: view

No data available for Paralogs for FUK Gene

Variants for FUK Gene

Sequence variations from dbSNP and Humsavar for FUK Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs744672 -- 70,470,064(+) GGTCT(C/G)GAACT intron-variant
rs2099539 -- 70,470,935(-) GGGTC(A/C/G)AGGCC intron-variant
rs7188297 -- 70,460,570(+) tggct(A/G)atttt intron-variant
rs7188474 -- 70,460,593(+) agaga(C/T)ggggt intron-variant
rs7188808 -- 70,460,577(+) ttttt(A/G)tattt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUK Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER Inversion 18451855
nsv833272 CNV Loss 17160897
nsv906873 CNV Loss 21882294

Relevant External Links for FUK Gene

HapMap Linkage Disequilibrium report
FUK

Disorders for FUK Gene

No disorders were found for FUK Gene.

No data available for UniProtKB/Swiss-Prot for FUK Gene

Publications for FUK Gene

  1. Identification of human L-fucose kinase amino acid sequence. (PMID: 12056818) Hinderlich S. … Bauer C. (Biochem. Biophys. Res. Commun. 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for FUK Gene

  • Addgene plasmids for FUK

Sources for FUK Gene

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