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Aliases for FUCA2 Gene

Aliases for FUCA2 Gene

  • Fucosidase, Alpha-L- 2, Plasma 2 3 5
  • Alpha-L-Fucoside Fucohydrolase 2 3 4
  • Alpha-L-Fucosidase 2 3 4
  • EC 4 63
  • DJ20N2.5 3

External Ids for FUCA2 Gene

Previous GeneCards Identifiers for FUCA2 Gene

  • GC06U990037
  • GC06M143797
  • GC06M143796
  • GC06M143857
  • GC06M141380

Summaries for FUCA2 Gene

Entrez Gene Summary for FUCA2 Gene

  • This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]

GeneCards Summary for FUCA2 Gene

FUCA2 (Fucosidase, Alpha-L- 2, Plasma) is a Protein Coding gene. Diseases associated with FUCA2 include Angiokeratoma. Among its related pathways are Other glycan degradation. GO annotations related to this gene include fucose binding and alpha-L-fucosidase activity. An important paralog of this gene is FUCA1.

UniProtKB/Swiss-Prot for FUCA2 Gene

  • Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Gene Wiki entry for FUCA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUCA2 Gene

Genomics for FUCA2 Gene

Regulatory Elements for FUCA2 Gene

Enhancers for FUCA2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FUCA2 on UCSC Golden Path with GeneCards custom track

Promoters for FUCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUCA2 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUCA2 Gene

143,494,811 bp from pter
143,511,883 bp from pter
17,073 bases
Minus strand

Genomic View for FUCA2 Gene

Genes around FUCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUCA2 Gene

Proteins for FUCA2 Gene

  • Protein details for FUCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Plasma alpha-L-fucosidase
    Protein Accession:
    Secondary Accessions:
    • E9PEB6
    • Q7Z6V1
    • Q7Z6Y2
    • Q8NBK4

    Protein attributes for FUCA2 Gene

    467 amino acids
    Molecular mass:
    54067 Da
    Quaternary structure:
    • Homotetramer.

    Alternative splice isoforms for FUCA2 Gene


neXtProt entry for FUCA2 Gene

Proteomics data for FUCA2 Gene at MOPED

Selected DME Specific Peptides for FUCA2 Gene

Post-translational modifications for FUCA2 Gene

  • Ubiquitination at Lys 85
  • Glycosylation at Asn 171, Asn 239, and Asn 377
  • Modification sites at PhosphoSitePlus

Other Protein References for FUCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FUCA2

Domains & Families for FUCA2 Gene

Suggested Antigen Peptide Sequences for FUCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 29 family.
  • Belongs to the glycosyl hydrolase 29 family.
genes like me logo Genes that share domains with FUCA2: view

No data available for Gene Families for FUCA2 Gene

Function for FUCA2 Gene

Molecular function for FUCA2 Gene

GENATLAS Biochemistry:
fucosidase,alpha-L-2,plasma,isoform,cleaving fucose from the non reducing and of a variety of oligosaccharides (glycoprotein isoform catabolism)
UniProtKB/Swiss-Prot CatalyticActivity:
An alpha-L-fucoside + H(2)O = L-fucose + an alcohol.
UniProtKB/Swiss-Prot Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Enzyme Numbers (IUBMB) for FUCA2 Gene

genes like me logo Genes that share phenotypes with FUCA2: view

Human Phenotype Ontology for FUCA2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for FUCA2

No data available for Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUCA2 Gene

Localization for FUCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUCA2 Gene


Subcellular locations from

Jensen Localization Image for FUCA2 Gene COMPARTMENTS Subcellular localization image for FUCA2 gene
Compartment Confidence
extracellular 5
lysosome 4
vacuole 4
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for FUCA2 Gene

Pathways & Interactions for FUCA2 Gene

SuperPathways for FUCA2 Gene

Superpath Contained pathways
1 Other glycan degradation
genes like me logo Genes that share pathways with FUCA2: view

Pathways by source for FUCA2 Gene

1 KEGG pathway for FUCA2 Gene

Interacting Proteins for FUCA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9BTY2-FUCO2_HUMAN ENSP00000002165 for FUCA2 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0009617 response to bacterium IMP 19666478
GO:0016139 glycoside catabolic process IDA 19666478
genes like me logo Genes that share ontologies with FUCA2: view

No data available for SIGNOR curated interactions for FUCA2 Gene

Drugs & Compounds for FUCA2 Gene

(2) Drugs for FUCA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0

(6) Additional Compounds for FUCA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
Isopropyl alcohol
  • 2-Propanol
  • 2-Propyl alcohol
  • Alcojel
  • Alkolave
  • Avantin
  • (-)-Fucose
  • (-)-L-Fucose
  • 6-Deoxy-beta-galactose
  • 6-Deoxy-D-galactopyranose
  • 6-Deoxy-delta-galactopyranose
genes like me logo Genes that share compounds with FUCA2: view

Transcripts for FUCA2 Gene

mRNA/cDNA for FUCA2 Gene

Unigene Clusters for FUCA2 Gene

Fucosidase, alpha-L- 2, plasma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUCA2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - - - -
SP4: - -
SP5: - - - -

Relevant External Links for FUCA2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUCA2 Gene

mRNA expression in normal human tissues for FUCA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUCA2 Gene

This gene is overexpressed in Serum (43.1) and Nasal epithelium (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FUCA2 Gene

SOURCE GeneReport for Unigene cluster for FUCA2 Gene Hs.17680

genes like me logo Genes that share expression patterns with FUCA2: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for FUCA2 Gene

Orthologs for FUCA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUCA2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FUCA2 35
  • 87.99 (n)
  • 87.76 (a)
FUCA2 36
  • 82 (a)
(Canis familiaris)
Mammalia FUCA2 35
  • 88.01 (n)
  • 84.69 (a)
FUCA2 36
  • 84 (a)
(Mus musculus)
Mammalia Fuca2 35
  • 82.99 (n)
  • 84.44 (a)
Fuca2 16
Fuca2 36
  • 82 (a)
(Pan troglodytes)
Mammalia FUCA2 35
  • 99.85 (n)
  • 100 (a)
FUCA2 36
  • 97 (a)
(Rattus norvegicus)
Mammalia Fuca2 35
  • 82.76 (n)
  • 85.19 (a)
(Monodelphis domestica)
Mammalia FUCA2 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia FUCA2 36
  • 82 (a)
(Gallus gallus)
Aves FUCA2 35
  • 75.04 (n)
  • 77.19 (a)
FUCA2 36
  • 72 (a)
(Anolis carolinensis)
Reptilia FUCA2 36
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fuca2 35
  • 68.57 (n)
  • 69.79 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68702 35
(Danio rerio)
Actinopterygii -- 35
fuca2 35
  • 63.05 (n)
  • 65.59 (a)
fuca2 36
  • 64 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9330 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007285 35
  • 56.91 (n)
  • 53.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fuca 35
  • 59.14 (n)
  • 57.53 (a)
Fuca 36
  • 41 (a)
(Caenorhabditis elegans)
Secernentea W03G11.3 35
  • 58.36 (n)
  • 54.39 (a)
W03G11.3 36
  • 38 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3711 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
-- 36
  • 53 (a)
-- 36
  • 47 (a)
CSA.1698 36
  • 53 (a)
CSA.1844 36
  • 57 (a)
Species with no ortholog for FUCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUCA2 Gene

Gene Tree for FUCA2 (if available)
Gene Tree for FUCA2 (if available)

Paralogs for FUCA2 Gene

Paralogs for FUCA2 Gene

(1) SIMAP similar genes for FUCA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FUCA2: view

Variants for FUCA2 Gene

Sequence variations from dbSNP and Humsavar for FUCA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3762002 - 143,502,020(+) CCCCA(C/T)TTGCC reference, missense
rs3762001 - 143,501,975(+) GGTAT(A/G)GGTTT reference, missense
VAR_055822 -
rs1338532 -- 143,497,103(-) acgca(C/T)ctgta intron-variant
rs5880564 -- 143,498,170(+) AAAAA(-/A/AA)GTGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUCA2 Gene

Variant ID Type Subtype PubMed ID
dgv2014e1 CNV Complex 17122850

Variation tolerance for FUCA2 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.56; 94.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for FUCA2 Gene

Disorders for FUCA2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FUCA2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
  • angiokeratoma of skin
- elite association - COSMIC cancer census association via MalaCards
Search FUCA2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUCA2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FUCA2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUCA2 Gene

Publications for FUCA2 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48 67
  2. Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells. (PMID: 19666478) Liu T.W. … Lin C.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Cell surface human alpha-L-fucosidase. (PMID: 11389735) Cordero O.J. … RodrA-guez-Berrocal F.J. (Eur. J. Biochem. 2001) 3 23
  4. Specification of small distal 6q deletions in two patients by gene dosage and in situ hybridization study of plasminogen and alpha-L-fucosidase 2. (PMID: 1951444) Narahara K. … Wakui K. (Am. J. Med. Genet. 1991) 3 23
  5. Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system. (PMID: 6590153) Eiberg H. … Nielsen L.S. (Clin. Genet. 1984) 2 3

Products for FUCA2 Gene

Sources for FUCA2 Gene