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FUCA2 Gene

protein-coding   GIFtS: 62
GCID: GC06M143857

Fucosidase, Alpha-L- 2, Plasma

  See FUCA2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fucosidase, Alpha-L- 2, Plasma1 2
Alpha-L-Fucosidase 22 3
Alpha-L-Fucoside Fucohydrolase 22 3
EC 3.2.1.513 8
dJ20N2.52
Plasma Alpha-L-Fucosidase2

External Ids:    HGNC: 40081   Entrez Gene: 25192   Ensembl: ENSG000000010367   OMIM: 1368205   UniProtKB: Q9BTY23   

Export aliases for FUCA2 gene to outside databases

Previous GC identifers: GC06U990037 GC06M143797 GC06M143796 GC06M141380


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FUCA2 Gene:
This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity.
The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked
fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme
is essential for Helicobacter pylori adhesion to human gastric cancer cells. (provided by RefSeq, Aug 2010)

GeneCards Summary for FUCA2 Gene:
FUCA2 (fucosidase, alpha-L- 2, plasma) is a protein-coding gene. Diseases associated with FUCA2 include laryngotracheitis, and spastic quadriplegia. GO annotations related to this gene include alpha-L-fucosidase activity and fucose binding. An important paralog of this gene is FUCA1.

UniProtKB/Swiss-Prot: FUCO2_HUMAN, Q9BTY2
Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end
N-acetylglucosamine of the carbohydrate moieties of glycoproteins

Gene Wiki entry for FUCA2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FUCA2 gene promoter:
         AML1a   GCNF   Brachyury   HNF-1A   Arnt   FOXL1   HNF-1   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUCA2 promoter sequence
   Search Chromatin IP Primers for FUCA2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUCA2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q24   Ensembl cytogenetic band:  6q24.2   HGNC cytogenetic band: 6q24

FUCA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUCA2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M143857:  view genomic region     (about GC identifiers)

Start:
143,815,948 bp from pter      End:
143,833,020 bp from pter
Size:
17,073 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FUCO2_HUMAN, Q9BTY2 (See protein sequence)
Recommended Name: Plasma alpha-L-fucosidase precursor  
Size: 467 amino acids; 54067 Da
Subunit: Homotetramer (By similarity)
Secondary accessions: Q7Z6Y2 Q8NBK4

Explore the universe of human proteins at neXtProt for FUCA2: NX_Q9BTY2

Explore proteomics data for FUCA2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys85
  • Glycosylation2 at Asn171, Asn239, Asn377
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for FUCA2 (Q9BTY2) (see all 7)
     KHHEGFT  KWENCMT  KFGIFIH  HWGVFSVP 


    See FUCA2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_114409.2  
    ENSEMBL proteins: 
     ENSP00000002165   ENSP00000398119   ENSP00000394151  

    FUCA2 Human Recombinant Protein Products:

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    Novus Biologicals FUCA2 Proteins
    Novus Biologicals FUCA2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for FUCA2 

     
    antibodies-online proteins for FUCA2 (10 products) 

     
    antibodies-online peptides for FUCA2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR016286 FUC_metazoa-typ
     IPR028756 FUCA2
     IPR017853 Glycoside_hydrolase_SF
     IPR013781 Glyco_hydro_catalytic_dom
     IPR018526 Glyco_hydro_29_CS

    Graphical View of Domain Structure for InterPro Entry Q9BTY2

    ProtoNet protein and cluster: Q9BTY2

    1 Blocks protein domain: IPB000933 Glycoside hydrolase

    UniProtKB/Swiss-Prot: FUCO2_HUMAN, Q9BTY2
    Similarity: Belongs to the glycosyl hydrolase 29 family


    Find genes that share domains with FUCA2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUCO2_HUMAN, Q9BTY2
    Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end
    N-acetylglucosamine of the carbohydrate moieties of glycoproteins
    Catalytic activity: An alpha-L-fucoside + H(2)O = L-fucose + an alcohol

         Genatlas biochemistry entry for FUCA2:
    fucosidase,alpha-L-2,plasma,isoform,cleaving fucose from the non reducing and of a variety of oligosaccharides
    (glycoprotein isoform catabolism)

         Enzyme Number (IUBMB): EC 3.2.1.511 2

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004560alpha-L-fucosidase activity IDA19666478
    GO:0042806fucose binding IBA--
         
    Find genes that share ontologies with FUCA2           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for FUCA2:
     Elongated cells  Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Fuca2 (no phenotypes)

    Find genes that share phenotypes with FUCA2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Fuca2tm1Lex for FUCA2

       genOway: Develop your customized and physiologically relevant rodent model for FUCA2

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    hsa-miR-3611 hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidFUCA2 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat FUCA2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FUCO2_HUMAN, Q9BTY2: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    lysosome3
    mitochondrion2
    nucleus2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005615extracellular space IDA19666478
    GO:0005764lysosome IBA--

    Find genes that share ontologies with FUCA2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for FUCA2 About    
    See pathways by source

    SuperPathContained pathways About
    1Other glycan degradation
    Other glycan degradation


    Find genes that share SuperPaths with FUCA2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for FUCA2):
        Other glycan degradation

        Pathway & Disease-focused RT2 Profiler PCR Array including FUCA2: 
              Glycosylation in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for FUCA2

    3 Interacting proteins for FUCA2 (Q9BTY22, 3) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLN3Q132863I2D: score=1 
    KRTAP4-12Q9BQ663I2D: score=1 
    --Q9WMX22MINT-7049439
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005975carbohydrate metabolic process ----
    GO:0006004fucose metabolic process IDA19666478
    GO:0009617response to bacterium IMP19666478
    GO:0016139glycoside catabolic process IDA19666478
    GO:2000535regulation of entry of bacterium into host cell IMP19666478

    Find genes that share ontologies with FUCA2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FUCA2 (FUCO2)

    9 HMDB Compounds for FUCA2    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Butanol1-Butanol (see all 10)71-36-3--
    1-Hexanol1-Hexyl alcohol (see all 30)111-27-3--
    1-Pentanol1-Pentol (see all 34)71-41-0--
    Ethanol1-Hydroxyethane (see all 57)64-17-5--
    Isobutanol1-Hydroxymethylpropane (see all 18)78-83-1--
    Isopropyl alcohol2-Propanol (see all 12)67-63-0--
    L-Fucose(-)-Fucose (see all 19)2438-80-4--
    Propyl alcohol1-Hydroxypropane (see all 17)71-23-8--
    WaterDihydrogen oxide (see all 2)7732-18-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FUCA2 gene: 
    NM_032020.4  

    Unigene Cluster for FUCA2:

    Fucosidase, alpha-L- 2, plasma
    Hs.17680  [show with all ESTs]
    Unigene Representative Sequence: NM_032020
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000002165(uc003qjm.3) ENST00000451668 ENST00000367585 ENST00000438118(uc003qjn.3)

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate FUCA2:
    hsa-miR-3611 hsa-miR-107 hsa-miR-103a
    SwitchGear 3'UTR luciferase reporter plasmidFUCA2 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat FUCA2
      QuantiFast Probe-based Assays in human, mouse, rat FUCA2

    Additional mRNA sequence: 

    AK075458.1 AK315475.1 AY358551.1 BC003060.2 BC051268.1 

    10 DOTS entries:

    DT.215295  DT.91757289  DT.91757293  DT.100838721  DT.95143141  DT.91757288  DT.121384230  DT.121384243 
    DT.95072608  DT.95216704 

    Selected AceView cDNA sequences (see all 343):

    BM790162 CA454532 BM747554 BQ923105 BG774675 AI432943 CR596039 BI260872 
    BM985072 AI565199 BQ920154 BM791272 CA412923 CB119767 CN485153 CB136375 
    CR604858 BE734344 BX381873 CA488906 CR619981 AI249273 AA583023 CR597696 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FUCA2 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7
    SP1:                          -                       -                             -         
    SP2:                          -     -     -           -                                       
    SP3:                                                                                          
    SP4:                          -     -                                                         
    SP5:                          -                       -     -     -                           


    ECgene alternative splicing isoforms for FUCA2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FUCA2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACCATTTT
    FUCA2 Expression
    About this image


    FUCA2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Heart (Cardiovascular System)
     
     Kidney (Urinary System)
    FUCA2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FUCA2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.17680
        Pathway & Disease-focused RT2 Profiler PCR Array including FUCA2: 
              Glycosylation in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat FUCA2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUCA2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FUCA2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fuca21 , 5 fucosidase, alpha-L- 2, plasma1, 5 82.99(n)1
    84.44(a)1
      10 (4.86 cM)5
    668481  NM_025799.41  NP_080075.21 
     134995405 
    chicken
    (Gallus gallus)
    Aves FUCA21 fucosidase, alpha-L- 2, plasma 75.04(n)
    77.19(a)
      421668  XM_419707.4  XP_419707.3 
    lizard
    (Anolis carolinensis)
    Reptilia FUCA26
    fucosidase, alpha-L- 2, plasma
    67(a)
    1 ↔ 1
    1(203899738-203905208)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC687022 hypothetical protein MGC68702 78.66(n)    BC059989.1 
    zebrafish
    (Danio rerio)
    Actinopterygii CK018204.12   -- 73.55(n)   324149  CK018204.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Fuca1 alpha-L-fucosidase 59.14(n)
    57.53(a)
      3772574  NM_140215.3  NP_648472.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W03G11.31 W03G11.3 58.36(n)
    54.39(a)
      189173  NM_077619.3  NP_510020.2 


    ENSEMBL Gene Tree for FUCA2 (if available)
    TreeFam Gene Tree for FUCA2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FUCA2 gene
    FUCA12  
    1 SIMAP similar gene for FUCA2 using alignment to 3 protein entries:     FUCO2_HUMAN (see all proteins):
    FUCA1

    Find genes that share paralogs with FUCA2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FUCA2 (see all 485)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929345711,2
    --143814014(+) TGCTGC/GTATAA 1 -- ds50010--------
    rs1120090201,2
    F--143814076(+) GGTATA/TTAGTA 1 -- ds50012Minor allele frequency- T:0.04CSA WA 120
    rs1421355151,2
    --143814077(+) GTATAC/TAGTAC 1 -- ds50010--------
    rs1841257461,2
    --143814231(+) TGTTAC/TAGGAG 1 -- ds50010--------
    rs1884704471,2
    C--143814248(+) GCTCCA/GTGGGT 1 -- ds50010--------
    rs1457754571,2
    C--143814272(+) AAAAC-/CTTCTAAG 1 -- ds50010--------
    rs1924920761,2
    --143814513(+) TAAAAC/TGTTTG 1 -- ut310--------
    rs349534961,2
    C--143814576(+) ATAAA-/AATGTAG 1 -- ut310--------
    rs715442941,2
    C--143814580(-) ACTAC-/CA/T  
      ATT
    /TT
    ATTTA
    3 -- ut311NA 2
    rs360238021,2
    C,F--143814581(+) TAAATG/ATAGTG 1 -- ut312Minor allele frequency- A:0.28NA EA 240

    HapMap Linkage Disequilibrium report for FUCA2 (143815948 - 143833020 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FUCA2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv2014e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FUCA2
    DNA2.0 Custom Variant and Variant Library Synthesis for FUCA2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 136820    OMIM disorders: --

    4 diseases for FUCA2:    
    About MalaCards
    laryngotracheitis    spastic quadriplegia    quadriplegia    fucosidosis

    3 diseases from the University of Copenhagen DISEASES database for FUCA2:
    Fucosidosis     Laryngotracheitis     Spastic quadriplegia

    Find genes that share disorders with FUCA2           About GenesLikeMe

    Genetic Association Database (GAD): FUCA2
    Human Genome Epidemiology (HuGE) Navigator: FUCA2 (1 document)

    Export disorders for FUCA2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for FUCA2 gene, integrated from 10 sources (see all 28):
    (articles sorted by number of sources associating them with FUCA2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system. (PubMed id 6590153)1, 3 Eiberg H....Nielsen L.S. (Clin. Genet. 1984)
    7. Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells. (PubMed id 19666478)1, 9 Liu T.W....Lin C.H. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    8. Specification of small distal 6q deletions in two patients by gene dosage and in situ hybridization study of plasminogen and alpha-L-fucosidase 2. (PubMed id 1951444)1, 9 Narahara K....Wakui K. (Am. J. Med. Genet. 1991)
    9. Cell surface human alpha-L-fucosidase. (PubMed id 11389735)1, 9 Cordero O.J....RodrA-guez-Berrocal F.J. (Eur. J. Biochem. 2001)
    10. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 2519 HGNC: 4008 AceView: FUCA2 Ensembl:ENSG00000001036 euGenes: HUgn2519
    ECgene: FUCA2 Kegg: 2519 H-InvDB: FUCA2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for FUCA2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for FUCA2 gene:
    Search GeneIP for patents involving FUCA2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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