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Aliases for FUCA2 Gene

Aliases for FUCA2 Gene

  • Fucosidase, Alpha-L- 2, Plasma 2 3
  • Alpha-L-Fucoside Fucohydrolase 2 3 4
  • Alpha-L-Fucosidase 2 3 4
  • EC 3.2.1.51 4 63
  • Plasma Alpha-L-Fucosidase 3
  • DJ20N2.5 3

External Ids for FUCA2 Gene

Previous GeneCards Identifiers for FUCA2 Gene

  • GC06U990037
  • GC06M143797
  • GC06M143796
  • GC06M143857
  • GC06M141380

Summaries for FUCA2 Gene

Entrez Gene Summary for FUCA2 Gene

  • This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]

GeneCards Summary for FUCA2 Gene

FUCA2 (Fucosidase, Alpha-L- 2, Plasma) is a Protein Coding gene. Diseases associated with FUCA2 include laryngotracheitis and spastic quadriplegia. Among its related pathways are Other glycan degradation. GO annotations related to this gene include fucose binding and alpha-L-fucosidase activity. An important paralog of this gene is FUCA1.

UniProtKB/Swiss-Prot for FUCA2 Gene

  • Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins

Gene Wiki entry for FUCA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUCA2 Gene

Genomics for FUCA2 Gene

Regulatory Elements for FUCA2 Gene

Genomic Location for FUCA2 Gene

Start:
143,494,811 bp from pter
End:
143,511,883 bp from pter
Size:
17,073 bases
Orientation:
Minus strand

Genomic View for FUCA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUCA2 Gene

Proteins for FUCA2 Gene

  • Protein details for FUCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTY2-FUCO2_HUMAN
    Recommended name:
    Plasma alpha-L-fucosidase
    Protein Accession:
    Q9BTY2
    Secondary Accessions:
    • E9PEB6
    • Q7Z6V1
    • Q7Z6Y2
    • Q8NBK4

    Protein attributes for FUCA2 Gene

    Size:
    467 amino acids
    Molecular mass:
    54067 Da
    Quaternary structure:
    • Homotetramer.

    Alternative splice isoforms for FUCA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUCA2 Gene

Proteomics data for FUCA2 Gene at MOPED

Selected DME Specific Peptides for FUCA2 Gene

Post-translational modifications for FUCA2 Gene

  • Ubiquitination at Lys85
  • Glycosylation at Asn171, Asn239, and Asn377
  • Modification sites at PhosphoSitePlus

Other Protein References for FUCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for FUCA2 Gene

Suggested Antigen Peptide Sequences for FUCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTY2

UniProtKB/Swiss-Prot:

FUCO2_HUMAN :
  • Q9BTY2
Family:
  • Belongs to the glycosyl hydrolase 29 family.
genes like me logo Genes that share domains with FUCA2: view

No data available for Gene Families for FUCA2 Gene

Function for FUCA2 Gene

Molecular function for FUCA2 Gene

GENATLAS Biochemistry: fucosidase,alpha-L-2,plasma,isoform,cleaving fucose from the non reducing and of a variety of oligosaccharides (glycoprotein isoform catabolism)
UniProtKB/Swiss-Prot CatalyticActivity: An alpha-L-fucoside + H(2)O = L-fucose + an alcohol.
UniProtKB/Swiss-Prot Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins

Enzyme Numbers (IUBMB) for FUCA2 Gene

Gene Ontology (GO) - Molecular Function for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004560 alpha-L-fucosidase activity IDA 19666478
GO:0005515 protein binding IPI 25416956
GO:0042806 fucose binding IBA --
genes like me logo Genes that share ontologies with FUCA2: view

Phenotypes for FUCA2 Gene

GenomeRNAi human phenotypes for FUCA2:
genes like me logo Genes that share phenotypes with FUCA2: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for FUCA2 Gene

Localization for FUCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUCA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUCA2 Gene COMPARTMENTS Subcellular localization image for FUCA2 gene
Compartment Confidence
extracellular 4
lysosome 3
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 19666478
GO:0005764 lysosome IBA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FUCA2: view

Pathways for FUCA2 Gene

SuperPathways for FUCA2 Gene

Superpath Contained pathways
1 Other glycan degradation
genes like me logo Genes that share pathways with FUCA2: view

Pathways by source for FUCA2 Gene

1 KEGG pathway for FUCA2 Gene

Interacting Proteins for FUCA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000002165%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9BTY2-FUCO2_HUMAN ENSP00000002165 for FUCA2 Gene via MINT STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process --
GO:0006004 fucose metabolic process IDA 19666478
GO:0009617 response to bacterium IMP 19666478
GO:0016139 glycoside catabolic process IDA 19666478
GO:2000535 regulation of entry of bacterium into host cell IMP 19666478
genes like me logo Genes that share ontologies with FUCA2: view

Compounds for FUCA2 Gene

(9) HMDB Compounds for FUCA2 Gene

Compound Synonyms Cas Number PubMed IDs
1-Butanol
  • 1-Butanol
71-36-3
1-Hexanol
  • 1-Hexyl alcohol
111-27-3
1-Pentanol
  • 1-Pentol
71-41-0
Ethanol
  • 1-Hydroxyethane
64-17-5
Isobutanol
  • 1-Hydroxymethylpropane
78-83-1
genes like me logo Genes that share compounds with FUCA2: view

Transcripts for FUCA2 Gene

mRNA/cDNA for FUCA2 Gene

Unigene Clusters for FUCA2 Gene

Fucosidase, alpha-L- 2, plasma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUCA2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for FUCA2 Gene

GeneLoc Exon Structure for
FUCA2
ECgene alternative splicing isoforms for
FUCA2

Expression for FUCA2 Gene

mRNA expression in normal human tissues for FUCA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUCA2 Gene

SOURCE GeneReport for Unigene cluster for FUCA2 Gene Hs.17680

genes like me logo Genes that share expressions with FUCA2: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FUCA2 Gene

Orthologs for FUCA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUCA2 35
  • 99.85 (n)
  • 100 (a)
FUCA2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUCA2 35
  • 87.99 (n)
  • 87.76 (a)
FUCA2 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUCA2 35
  • 88.01 (n)
  • 84.69 (a)
FUCA2 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fuca2 35
  • 82.99 (n)
  • 84.44 (a)
Fuca2 16
Fuca2 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUCA2 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUCA2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fuca2 35
  • 82.76 (n)
  • 85.19 (a)
chicken
(Gallus gallus)
Aves FUCA2 35
  • 75.04 (n)
  • 77.19 (a)
FUCA2 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUCA2 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68702 35
tropical clawed frog
(Silurana tropicalis)
Amphibia fuca2 35
  • 68.57 (n)
  • 69.79 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9330 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
fuca2 35
  • 63.05 (n)
  • 65.59 (a)
fuca2 36
  • 64 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007285 35
  • 56.91 (n)
  • 53.69 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fuca 35
  • 59.14 (n)
  • 57.53 (a)
Fuca 36
  • 41 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea W03G11.3 35
  • 58.36 (n)
  • 54.39 (a)
W03G11.3 36
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3711 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
ManyToMany
-- 36
  • 53 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
CSA.1698 36
  • 53 (a)
ManyToMany
CSA.1844 36
  • 57 (a)
ManyToMany
Species with no ortholog for FUCA2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUCA2 Gene

ENSEMBL:
Gene Tree for FUCA2 (if available)
TreeFam:
Gene Tree for FUCA2 (if available)

Paralogs for FUCA2 Gene

Paralogs for FUCA2 Gene

Selected SIMAP similar genes for FUCA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FUCA2: view

Variants for FUCA2 Gene

Sequence variations from dbSNP and Humsavar for FUCA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs8161 -- 143,495,722(-) GCCCT(A/G)ACTAA synonymous-codon, reference
rs170343 -- 143,496,731(-) ACAAG(A/T)TGTCA intron-variant
rs170344 -- 143,508,894(-) AATTA(A/G)TCAAT intron-variant
rs223230 -- 143,496,580(-) GTGAA(C/T)TGTCC intron-variant
rs223232 -- 143,504,865(-) AGGGG(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUCA2 Gene

Variant ID Type Subtype PubMed ID
dgv2014e1 CNV Complex 17122850

Relevant External Links for FUCA2 Gene

HapMap Linkage Disequilibrium report
FUCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUCA2 Gene

Disorders for FUCA2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for FUCA2 Gene including...

Search for FUCA2 Gene in MalaCards »

(3) University of Copenhagen DISEASES for FUCA2 Gene

Relevant External Links for FUCA2

Genetic Association Database (GAD)
FUCA2
Human Genome Epidemiology (HuGE) Navigator
FUCA2
genes like me logo Genes that share disorders with FUCA2: view

No data available for UniProtKB/Swiss-Prot for FUCA2 Gene

Publications for FUCA2 Gene

  1. Cell surface human alpha-L-fucosidase. (PMID: 11389735) Cordero O.J. … RodrA-guez-Berrocal F.J. (Eur. J. Biochem. 2001) 3 23
  2. Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells. (PMID: 19666478) Liu T.W. … Lin C.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system. (PMID: 6590153) Eiberg H. … Nielsen L.S. (Clin. Genet. 1984) 2 3
  4. Specification of small distal 6q deletions in two patients by gene dosage and in situ hybridization study of plasminogen and alpha-L-fucosidase 2. (PMID: 1951444) Narahara K. … Wakui K. (Am. J. Med. Genet. 1991) 3 23
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4

Products for FUCA2 Gene

Sources for FUCA2 Gene

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