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Aliases for FUCA2 Gene

Aliases for FUCA2 Gene

  • Fucosidase, Alpha-L- 2, Plasma 2 3 5
  • Alpha-L-Fucoside Fucohydrolase 2 3 4
  • Alpha-L-Fucosidase 2 3 4
  • EC 3.2.1.51 4 61
  • Plasma Alpha-L-Fucosidase 3
  • DJ20N2.5 3

External Ids for FUCA2 Gene

Previous GeneCards Identifiers for FUCA2 Gene

  • GC06U990037
  • GC06M143797
  • GC06M143796
  • GC06M143857
  • GC06M141380

Summaries for FUCA2 Gene

Entrez Gene Summary for FUCA2 Gene

  • This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]

GeneCards Summary for FUCA2 Gene

FUCA2 (Fucosidase, Alpha-L- 2, Plasma) is a Protein Coding gene. Among its related pathways are Immune System and Other glycan degradation. GO annotations related to this gene include fucose binding and alpha-L-fucosidase activity. An important paralog of this gene is FUCA1.

UniProtKB/Swiss-Prot for FUCA2 Gene

  • Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Gene Wiki entry for FUCA2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUCA2 Gene

Genomics for FUCA2 Gene

Regulatory Elements for FUCA2 Gene

Enhancers for FUCA2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F143566 1.3 FANTOM5 Ensembl ENCODE 10.4 -55.3 -55318 0.8 TBP CTCF TBL1XR1 BMI1 CHAMP1 RELA POLR2A CBX5 EED ETV6 PHACTR2 FUCA2 LTV1 ZC2HC1B PHACTR2-AS1
GH06F142940 1.4 Ensembl ENCODE 4.7 +567.6 567562 8.6 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ZNF143 ENSG00000233138 AIG1 FUCA2 HIVEP2 LOC105369170
GH06F143510 1.1 ENCODE 5.1 +0.4 420 1.8 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 VDAC1P8 FUCA2
GH06F144304 0.2 ENCODE 4.8 -792.9 -792936 0.8 ENSG00000225311 STX11 FUCA2 GC06P144306 UTRN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FUCA2 on UCSC Golden Path with GeneCards custom track

Promoters for FUCA2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001500962 1083 2401 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for FUCA2 Gene

Chromosome:
6
Start:
143,494,811 bp from pter
End:
143,511,883 bp from pter
Size:
17,073 bases
Orientation:
Minus strand

Genomic View for FUCA2 Gene

Genes around FUCA2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUCA2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUCA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUCA2 Gene

Proteins for FUCA2 Gene

  • Protein details for FUCA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BTY2-FUCO2_HUMAN
    Recommended name:
    Plasma alpha-L-fucosidase
    Protein Accession:
    Q9BTY2
    Secondary Accessions:
    • E9PEB6
    • Q7Z6V1
    • Q7Z6Y2
    • Q8NBK4

    Protein attributes for FUCA2 Gene

    Size:
    467 amino acids
    Molecular mass:
    54067 Da
    Quaternary structure:
    • Homotetramer.

    Alternative splice isoforms for FUCA2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUCA2 Gene

Selected DME Specific Peptides for FUCA2 Gene

Q9BTY2:
  • CGGNLLMNIGPT
  • HWGVFSVP
  • KFGIFIH
  • KWENCMT
  • KTLPELYELV
  • SVPSFGSEWFW
  • KHHEGFT

Post-translational modifications for FUCA2 Gene

  • Ubiquitination at Lys 85
  • Glycosylation at Asn 171, Asn 239, and Asn 377
  • Modification sites at PhosphoSitePlus

Other Protein References for FUCA2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FUCA2
  • Santa Cruz Biotechnology (SCBT) Antibodies for FUCA2

Domains & Families for FUCA2 Gene

Suggested Antigen Peptide Sequences for FUCA2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BTY2

UniProtKB/Swiss-Prot:

FUCO2_HUMAN :
  • Belongs to the glycosyl hydrolase 29 family.
Family:
  • Belongs to the glycosyl hydrolase 29 family.
genes like me logo Genes that share domains with FUCA2: view

No data available for Gene Families for FUCA2 Gene

Function for FUCA2 Gene

Molecular function for FUCA2 Gene

GENATLAS Biochemistry:
fucosidase,alpha-L-2,plasma,isoform,cleaving fucose from the non reducing and of a variety of oligosaccharides (glycoprotein isoform catabolism)
UniProtKB/Swiss-Prot CatalyticActivity:
An alpha-L-fucoside + H(2)O = L-fucose + an alcohol.
UniProtKB/Swiss-Prot Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Enzyme Numbers (IUBMB) for FUCA2 Gene

Gene Ontology (GO) - Molecular Function for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004560 alpha-L-fucosidase activity IDA 19666478
GO:0005515 protein binding IPI 25416956
GO:0016787 hydrolase activity IEA --
GO:0016798 hydrolase activity, acting on glycosyl bonds IEA --
genes like me logo Genes that share ontologies with FUCA2: view
genes like me logo Genes that share phenotypes with FUCA2: view

Human Phenotype Ontology for FUCA2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for FUCA2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FUCA2 Gene

Localization for FUCA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUCA2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUCA2 gene
Compartment Confidence
extracellular 5
lysosome 5
mitochondrion 2
nucleus 2
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA 19666478
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with FUCA2: view

Pathways & Interactions for FUCA2 Gene

genes like me logo Genes that share pathways with FUCA2: view

Pathways by source for FUCA2 Gene

2 Reactome pathways for FUCA2 Gene
1 KEGG pathway for FUCA2 Gene

Interacting Proteins for FUCA2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000002165%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: Q9BTY2-FUCO2_HUMAN ENSP00000002165 for FUCA2 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for FUCA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006004 fucose metabolic process IDA 19666478
GO:0008152 metabolic process IEA --
GO:0009617 response to bacterium IMP 19666478
GO:0016139 glycoside catabolic process IDA 19666478
genes like me logo Genes that share ontologies with FUCA2: view

No data available for SIGNOR curated interactions for FUCA2 Gene

Drugs & Compounds for FUCA2 Gene

(2) Drugs for FUCA2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Isopropyl alcohol Approved Pharma 0
Water Approved Pharma 0

(6) Additional Compounds for FUCA2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Butanol
  • 1-Butanol
  • 1-Butyl alcohol
  • Butanol
  • Butyl alcohol
  • Butyl hydroxide
71-36-3
1-Hexanol
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
111-27-3
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
Isobutanol
  • 1-Hydroxymethylpropane
  • 2-Methyl propanol
  • 2-Methyl-1-propanol
  • 2-Methyl-1-propanyl alcohol
  • 2-Methylpropan-1-ol
78-83-1
l-fucose
  • (-)-Fucose
  • (-)-L-Fucose
  • 6-Deoxy-beta-galactose
  • 6-Deoxy-D-galactopyranose
  • 6-Deoxy-delta-galactopyranose
2438-80-4
genes like me logo Genes that share compounds with FUCA2: view

Transcripts for FUCA2 Gene

mRNA/cDNA for FUCA2 Gene

Unigene Clusters for FUCA2 Gene

Fucosidase, alpha-L- 2, plasma:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUCA2 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7
SP1: - - -
SP2: - - - -
SP3:
SP4: - -
SP5: - - - -
SP6:

Relevant External Links for FUCA2 Gene

GeneLoc Exon Structure for
FUCA2
ECgene alternative splicing isoforms for
FUCA2

Expression for FUCA2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FUCA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUCA2 Gene

This gene is overexpressed in Serum (43.1) and Nasal epithelium (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FUCA2 Gene



NURSA nuclear receptor signaling pathways regulating expression of FUCA2 Gene:

FUCA2

SOURCE GeneReport for Unigene cluster for FUCA2 Gene:

Hs.17680
genes like me logo Genes that share expression patterns with FUCA2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for FUCA2 Gene

Orthologs for FUCA2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUCA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUCA2 34 35
  • 99.85 (n)
dog
(Canis familiaris)
Mammalia FUCA2 34 35
  • 88.01 (n)
cow
(Bos Taurus)
Mammalia FUCA2 34 35
  • 87.99 (n)
mouse
(Mus musculus)
Mammalia Fuca2 34 16 35
  • 82.99 (n)
rat
(Rattus norvegicus)
Mammalia Fuca2 34
  • 82.76 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FUCA2 35
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUCA2 35
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUCA2 34 35
  • 75.04 (n)
lizard
(Anolis carolinensis)
Reptilia FUCA2 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fuca2 34
  • 68.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68702 34
zebrafish
(Danio rerio)
Actinopterygii fuca2 34 35
  • 63.05 (n)
-- 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9330 34
fruit fly
(Drosophila melanogaster)
Insecta Fuca 34 35
  • 59.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007285 34
  • 56.91 (n)
worm
(Caenorhabditis elegans)
Secernentea W03G11.3 34 35
  • 58.36 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1844 35
  • 57 (a)
ManyToMany
-- 35
  • 53 (a)
ManyToMany
CSA.1698 35
  • 53 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
-- 35
  • 44 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3711 34
Species where no ortholog for FUCA2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUCA2 Gene

ENSEMBL:
Gene Tree for FUCA2 (if available)
TreeFam:
Gene Tree for FUCA2 (if available)

Paralogs for FUCA2 Gene

Paralogs for FUCA2 Gene

(1) SIMAP similar genes for FUCA2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with FUCA2: view

Variants for FUCA2 Gene

Sequence variations from dbSNP and Humsavar for FUCA2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1038390 -- 143,505,965(-) GCTGT(A/G)TGGCA intron-variant
rs10452657 -- 143,504,621(+) AGCAG(C/T)TCACA intron-variant
rs10484801 -- 143,510,734(+) TTAGT(C/T)AGAAA intron-variant
rs111394434 -- 143,507,901(+) TGGGC(C/T)CAAGC intron-variant
rs111404250 -- 143,497,529(+) ATAGT(A/G)GCAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUCA2 Gene

Variant ID Type Subtype PubMed ID
nsv965776 CNV duplication 23825009
esv2759475 CNV gain 17122850

Variation tolerance for FUCA2 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.56; 94.45% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUCA2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUCA2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUCA2 Gene

Disorders for FUCA2 Gene

Relevant External Links for FUCA2

Genetic Association Database (GAD)
FUCA2
Human Genome Epidemiology (HuGE) Navigator
FUCA2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUCA2

No disorders were found for FUCA2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUCA2 Gene

Publications for FUCA2 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  2. Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells. (PMID: 19666478) Liu T.W. … Lin C.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 22 64
  3. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64

Products for FUCA2 Gene

Sources for FUCA2 Gene

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