FUCA2 Gene
protein-coding GIFtS: 57
GCID: GC06M143857
|
|
fucosidase, alpha-L- 2, plasma
| |
Aliases for FUCA2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Fucosidase, Alpha-L- 2, Plasma1 2 | | EC 3.2.1.513 8 | | DJ20N2.51 | | MGC13141 | | Alpha-L-Fucosidase 22 3 | | Plasma Alpha-L-Fucosidase2 | | Alpha-L-Fucoside Fucohydrolase 22 3 | | |
Export aliases for FUCA2 gene to outside databasesPrevious GC identifers: GC06U990037 GC06M143797 GC06M143796 GC06M141380 |
Summaries for FUCA2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for FUCA2: This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. Theprotein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucosejoined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essentialfor Helicobacter pylori adhesion to human gastric cancer cells. (provided by RefSeq, Aug 2010) UniProtKB/Swiss-Prot: FUCO2_HUMAN, Q9BTY2Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-endN-acetylglucosamine of the carbohydrate moieties of glycoproteins Gene Wiki entry for FUCA2
|
Genomic Views for FUCA2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the FUCA2 gene promoter: AML1a GCNF Brachyury HNF-1A Arnt FOXL1 HNF-1 GCNF-1 GCNF-2 Other transcription factors
Search SABiosciences Chromatin IP Primers for FUCA2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUCA2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q24 Ensembl cytogenetic band: 6q24.2 HGNC cytogenetic band: 6q24FUCA2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M143857: view genomic region
(about GC identifiers)
Start:
|
143,815,949 bp from pter |
End:
|
143,833,020 bp from pter |
Size:
|
17,072 bases |
Orientation:
|
minus strand |
|
Proteins for FUCA2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: FUCO2_HUMAN, Q9BTY2 (See
protein sequence)Recommended Name: Plasma alpha-L-fucosidase precursor Size: 467 amino acids; 54067 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Secreted (Probable)
Secondary accessions: Q7Z6Y2 Q8NBK4Explore the universe of human proteins at neXtProt for FUCA2: NX_Q9BTY2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BTY2 4/7 DME Specific Peptides for FUCA2 (Q9BTY2) (see all 7)
FUCA2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114409.2 ENSEMBL proteins: ENSP00000002165 ENSP00000398119 ENSP00000356557 ENSP00000394151 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
FUCA2 for ontologies About GeneDecksing
FUCA2 Antibody Products: Assay Products for FUCA2: |
Protein
Domains / Families for FUCA2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FUCA2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9BTY2ProtoNet protein and cluster: Q9BTY2 1 Blocks protein family: IPB000933 Glycoside hydrolase
UniProtKB/Swiss-Prot: FUCO2_HUMAN, Q9BTY2Similarity: Belongs to the glycosyl hydrolase 29 family |
Function for FUCA2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: FUCO2_HUMAN, Q9BTY2Function: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-endN-acetylglucosamine of the carbohydrate moieties of glycoproteinsCatalytic activity: An alpha-L-fucoside + H(2)O = L-fucose + an alcohol Genatlas biochemistry entry for FUCA2:fucosidase,alpha-L-2,plasma,isoform,cleaving fucose from the non reducing and of a variety of oligosaccharides(glycoprotein isoform catabolism) Enzyme Number (IUBMB): EC 3.2.1.511 2
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUCA2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUCA2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FUCA2 (NM_032020) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUCA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUCA2  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUCA2 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004560 | alpha-L-fucosidase activity |
IEA | -- | | GO:0043169 | cation binding |
IEA | -- |
FUCA2 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for FUCA2: Animal Models: Mouse knock-out Fuca2tm1Lex for FUCA2 1 MGI phenotypic allele for Fuca2 (no phenotypes)
FUCA2 for phenotypes About GeneDecksing
|
Pathways & Interactions for FUCA2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Other glycan degradation | |
Pathway sources See GeneCards unified pathways Show all pathways
1
Kegg Pathway (Kegg details for FUCA2):
FUCA2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUCA2
3 Interacting proteins for FUCA2 (Q9BTY22, 3) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005975 | carbohydrate metabolic process |
-- | -- | | GO:0006004 | fucose metabolic process |
IEA | -- |
FUCA2 for ontologies About GeneDecksing
|
Drugs & Compounds for FUCA2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for FUCA2
9 HMDB Compounds for FUCA2 About this table Search CenterWatch for drugs/clinical trials and news about FUCA2 / FUCO2 
|
Transcripts for FUCA2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for FUCA2 gene: NM_032020.4 Unigene Cluster for FUCA2: Fucosidase, alpha-L- 2, plasma Hs.17680 [show with all ESTs]Unigene Representative Sequence: NM_0320204 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000002165(uc003qjm.3) ENST00000451668 ENST00000367585 ENST00000438118(uc003qjn.3)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUCA2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUCA2 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FUCA2 (NM_032020) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUCA2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUCA2  |
Additional cDNA sequence: AK075458.1 AK315475.1 AY358551.1 BC003060.2 BC051268.1 10 DOTS entries: DT.215295 DT.91757289 DT.91757293 DT.100838721 DT.95143141 DT.91757288 DT.121384230 DT.121384243 DT.95072608 DT.95216704 24/343 AceView cDNA sequences (see all 343): BM786374 BM985072 BM764134 CR604354 CD516955 CR594725 CR604858 BM754096 BM819927 CB119767 NM_032020 BI909743 BM919689 CA454087 AW594702 CB106898 AI459828 CB114041 CR596039 CR616303 BE272744 CA421870 BX537633 CR605098 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FUCA2 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for FUCA2
|
Expression for FUCA2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FUCA2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TAACCATTTT
About this image See FUCA2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for FUCA2
SOURCE GeneReport for Unigene cluster: Hs.17680 SABiosciences Expression via Pathway-Focused PCR Array including FUCA2:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUCA2 Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUCA2 |
Orthologs for FUCA2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FUCA2 gene from 7/23 species (see all 23) About this table
ENSEMBL Gene Tree for FUCA2 (if available) TreeFam Gene Tree for FUCA2 (if available)  |
Paralogs for FUCA2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for FUCA2 gene
- FUCA12
1 SIMAP similar gene for FUCA2 using alignment to 3 protein entries: FUCO2_HUMAN (see all proteins):FUCA1
FUCA2 for paralogs About GeneDecksing
|
Genomic Variants for FUCA2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 6 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for FUCA2 (143815949 - 143833020 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for FUCA2 1 CNV: 2656  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUCA2 |
|
Disorders
/ Diseases for FUCA2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FUCA2 for disorders About GeneDecksing
OMIM gene information: 136820
OMIM disorders: --
17 diseases for FUCA2: About MalaCardsgastric cancer spastic quadriplegia placental insufficiency laryngotracheitis fucosidosis quadriplegia mucolipidosis epididymitis cholestasis hepatitis b oral cancer spasticity hepatocellular carcinoma breast carcinoma hepatitis carcinoma alcoholism 4 diseases from the University of Copenhagen DISEASES database for FUCA2:Fucosidosis Laryngotracheitis Angiokeratoma Spastic quadriplegia Human Genome Epidemiology (HuGE) Navigator: FUCA2 (1 document) Export disorders for FUCA2 gene to outside databases
|
Publications for FUCA2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FUCA2 gene, integrated from 9 sources (see all 27): (articles sorted by number of sources associating them with FUCA2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system. (PubMed id 6590153)1, 3 Eiberg H....Nielsen L.S. (1984)
- Role for alpha-L-fucosidase in the control of Helicob acter pylori-infected gastric cancer cells. (PubMed id 19666478)1, 9 Liu T.W....Lin C.H. (2009)
- Specification of small distal 6q deletions in two patients by gene dosage and in situ hybridization study of plasminogen and alpha-L-fucosidase 2. (PubMed id 1951444)1, 9 Narahara K....Wakui K. (1991)
- Cell surface human alpha-L-fucosidase. (PubMed id 11389735)1, 9 Cordero O.J....Rodriguez-Berrocal F.J. (2001)
- Proteomic identification of common SCF ubiquitin ligas e FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)1 Liu B....Wang L.S. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for FUCA2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FUCA2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FUCA2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FUCA2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for FUCA2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FUCA2 gene: Search GeneIP for patents involving FUCA2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for FUCA2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FUCA2 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUCA2 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUCA2 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUCA2 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUCA2 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUCA2 |
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