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Aliases for FUCA1 Gene

Aliases for FUCA1 Gene

  • Fucosidase, Alpha-L- 1, Tissue 2 3 5
  • Alpha-L-Fucoside Fucohydrolase 1 3 4
  • Alpha-L-Fucosidase 1 3 4
  • Alpha-L-Fucosidase I 3 4
  • EC 4 63
  • EC 3.2.1 63
  • FUCA 3

External Ids for FUCA1 Gene

Previous GeneCards Identifiers for FUCA1 Gene

  • GC01U990065
  • GC01M023242
  • GC01M023641
  • GC01M023916
  • GC01M024044
  • GC01M024171
  • GC01M022423

Summaries for FUCA1 Gene

Entrez Gene Summary for FUCA1 Gene

  • The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]

GeneCards Summary for FUCA1 Gene

FUCA1 (Fucosidase, Alpha-L- 1, Tissue) is a Protein Coding gene. Diseases associated with FUCA1 include fucosidosis and lysosomal storage disease. Among its related pathways are Transport to the Golgi and subsequent modification and Lysosome. GO annotations related to this gene include carbohydrate binding and alpha-L-fucosidase activity. An important paralog of this gene is FUCA2.

UniProtKB/Swiss-Prot for FUCA1 Gene

  • Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Gene Wiki entry for FUCA1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUCA1 Gene

Genomics for FUCA1 Gene

Regulatory Elements for FUCA1 Gene

Promoters for FUCA1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUCA1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUCA1 Gene

23,845,077 bp from pter
23,868,369 bp from pter
23,293 bases
Minus strand

Genomic View for FUCA1 Gene

Genes around FUCA1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUCA1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUCA1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUCA1 Gene

Proteins for FUCA1 Gene

  • Protein details for FUCA1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tissue alpha-L-fucosidase
    Protein Accession:
    Secondary Accessions:
    • B2RBG3
    • Q14334
    • Q14335
    • Q3LID0
    • Q8NAC2

    Protein attributes for FUCA1 Gene

    466 amino acids
    Molecular mass:
    53689 Da
    Quaternary structure:
    • Homotetramer.
    • Sequence=AAA35519.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAA52481.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH17338.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAG37210.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA25646.1; Type=Miscellaneous discrepancy; Note=Translation of X01390 sequence produces a larger peptide than that shown in CAA25646.1.; Evidence={ECO:0000305};

neXtProt entry for FUCA1 Gene

Proteomics data for FUCA1 Gene at MOPED

Post-translational modifications for FUCA1 Gene

  • Glycosylation at Asn 241, Asn 268, and Asn 382
  • Modification sites at PhosphoSitePlus

Other Protein References for FUCA1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for FUCA1 (Tissue alpha-L-Fucosidase/FUCA1)

Domains & Families for FUCA1 Gene

Suggested Antigen Peptide Sequences for FUCA1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 29 family.
  • Belongs to the glycosyl hydrolase 29 family.
genes like me logo Genes that share domains with FUCA1: view

No data available for Gene Families for FUCA1 Gene

Function for FUCA1 Gene

Molecular function for FUCA1 Gene

GENATLAS Biochemistry:
fucosidase,alpha-L-1,tissue,lysosomal,cleaving fucose from the non reducing and of a variety of oligosaccharides (glycoprotein isoform catabolism)
UniProtKB/Swiss-Prot CatalyticActivity:
An alpha-L-fucoside + H(2)O = L-fucose + an alcohol.
UniProtKB/Swiss-Prot Function:
Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.

Enzyme Numbers (IUBMB) for FUCA1 Gene

Gene Ontology (GO) - Molecular Function for FUCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030246 carbohydrate binding IEA --
genes like me logo Genes that share ontologies with FUCA1: view
genes like me logo Genes that share phenotypes with FUCA1: view

Human Phenotype Ontology for FUCA1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FUCA1 Gene

Localization for FUCA1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUCA1 Gene


Subcellular locations from

Jensen Localization Image for FUCA1 Gene COMPARTMENTS Subcellular localization image for FUCA1 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for FUCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IC 11698403
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with FUCA1: view

Pathways & Interactions for FUCA1 Gene

genes like me logo Genes that share pathways with FUCA1: view

Gene Ontology (GO) - Biological Process for FUCA1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0006027 glycosaminoglycan catabolic process NAS 11698403
GO:0044267 cellular protein metabolic process TAS --
genes like me logo Genes that share ontologies with FUCA1: view

No data available for SIGNOR curated interactions for FUCA1 Gene

Drugs & Compounds for FUCA1 Gene

(5) Drugs for FUCA1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(20) Additional Compounds for FUCA1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • (-)-Fucose
  • (-)-L-Fucose
  • 6-Deoxy-beta-galactose
  • 6-Deoxy-D-galactopyranose
  • 6-Deoxy-delta-galactopyranose
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with FUCA1: view

Transcripts for FUCA1 Gene

mRNA/cDNA for FUCA1 Gene

Unigene Clusters for FUCA1 Gene

Fucosidase, alpha-L- 1, tissue:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUCA1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: -

Relevant External Links for FUCA1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUCA1 Gene

mRNA expression in normal human tissues for FUCA1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FUCA1 Gene

This gene is overexpressed in Colon - Transverse (x4.0).

Protein differential expression in normal tissues from HIPED for FUCA1 Gene

This gene is overexpressed in Lymph node (10.0) and Salivary gland (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for FUCA1 Gene

SOURCE GeneReport for Unigene cluster for FUCA1 Gene Hs.370858

genes like me logo Genes that share expression patterns with FUCA1: view

Protein tissue co-expression partners for FUCA1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for FUCA1 Gene

Orthologs for FUCA1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUCA1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FUCA1 35
  • 86.09 (n)
  • 86.7 (a)
FUCA1 36
  • 82 (a)
(Canis familiaris)
Mammalia FUCA1 35
  • 87.14 (n)
  • 86.07 (a)
FUCA1 36
  • 83 (a)
(Mus musculus)
Mammalia Fuca1 35
  • 83.83 (n)
  • 84.83 (a)
Fuca1 16
Fuca1 36
  • 83 (a)
(Pan troglodytes)
Mammalia FUCA1 35
  • 93.1 (n)
  • 89.93 (a)
FUCA1 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Fuca1 35
  • 83.02 (n)
  • 82.64 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 67 (a)
-- 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia FUCA1 36
  • 74 (a)
(Gallus gallus)
Aves FUCA1 35
  • 70.46 (n)
  • 71.23 (a)
FUCA1 36
  • 67 (a)
(Anolis carolinensis)
Reptilia FUCA1 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia fuca1 35
  • 68.22 (n)
  • 73.02 (a)
Str.16634 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.7265 35
(Danio rerio)
Actinopterygii wufc59h04 35
zgc:101116 35
  • 63.62 (n)
  • 66.74 (a)
fuca1 36
  • 63 (a)
FUCA1 (1 of 2) 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6128 37
  • 46 (a)
Fuca 36
  • 42 (a)
(Caenorhabditis elegans)
Secernentea W03G11.3 37
  • 45 (a)
W03G11.3 36
  • 40 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
-- 36
  • 47 (a)
-- 36
  • 43 (a)
CSA.1698 36
  • 43 (a)
CSA.1844 36
  • 48 (a)
Species with no ortholog for FUCA1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUCA1 Gene

Gene Tree for FUCA1 (if available)
Gene Tree for FUCA1 (if available)

Paralogs for FUCA1 Gene

Paralogs for FUCA1 Gene

(1) SIMAP similar genes for FUCA1 Gene using alignment to 1 proteins: Pseudogenes for FUCA1 Gene

genes like me logo Genes that share paralogs with FUCA1: view

Variants for FUCA1 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for FUCA1 Gene

There are two common alleles of FUCA1; FUCA1*1; also known as Fu1; has Arg-281 and FUCA1*2; also known as Fu2; has Gln-281.

Sequence variations from dbSNP and Humsavar for FUCA1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_002442 Fucosidosis (FUCA1D)
VAR_002443 Fucosidosis (FUCA1D)
rs13551 - 23,854,472(-) GCCAC(A/G)GAGCT reference, missense
rs2070956 - 23,868,258(-) GCGGC(C/G/T)GGCGG reference, missense, utr-variant-5-prime
rs1126512 - 23,854,523(-) GAACT(C/G)TTCCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for FUCA1 Gene

Variant ID Type Subtype PubMed ID
esv2745330 CNV Deletion 23290073
esv2742159 CNV Deletion 23290073
esv2745341 CNV Deletion 23290073
esv2745352 CNV Deletion 23290073
esv2745364 CNV Deletion 23290073
esv2745375 CNV Deletion 23290073

Variation tolerance for FUCA1 Gene

Residual Variation Intolerance Score: 48.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.82; 89.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUCA1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for FUCA1 Gene

MalaCards: The human disease database

(10) MalaCards diseases for FUCA1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • a-fucosidase deficiency
lysosomal storage disease
  • disorder of lysosomal enzyme
fabry disease
  • fabry disease, cardiac variant
mucolipidosis iii alpha/beta
  • pseudo-hurler polydystrophy
pseudo-hurler polydystrophy
  • mucolipidosis iii
- elite association - COSMIC cancer census association via MalaCards
Search FUCA1 in MalaCards View complete list of genes associated with diseases


  • Fucosidosis (FUCA1D) [MIM:230000]: An autosomal recessive lysosomal storage disease characterized by accumulation of fucose-containing glycolipids and glycoproteins in various tissues. Clinical signs include facial dysmorphism, dysostosis multiplex, moderate hepatomegaly, severe intellectual deficit, deafness, and according to age, angiokeratomas. {ECO:0000269 PubMed:7874128, ECO:0000269 PubMed:8504303, ECO:0000269 PubMed:9762612}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for FUCA1 Gene


Relevant External Links for FUCA1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FUCA1: view

Publications for FUCA1 Gene

  1. Human alpha-L-fucosidase: complete coding sequence from cDNA clones. (PMID: 2803312) Occhiodoro T. … Hopwood J.J. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 67
  2. Role for alpha-L-fucosidase in the control of Helicobacter pylori-infected gastric cancer cells. (PMID: 19666478) Liu T.W. … Lin C.H. (Proc. Natl. Acad. Sci. U.S.A. 2009) 3 23
  3. Purification and characterization of alpha-L-fucosidase from human primary hepatocarcinoma tissue. (PMID: 16773698) Li C. … Lin J.S. (World J. Gastroenterol. 2006) 3 23
  4. Cell surface human alpha-L-fucosidase. (PMID: 11389735) Cordero O.J. … RodrA-guez-Berrocal F.J. (Eur. J. Biochem. 2001) 3 23
  5. New leads for selective inhibitors of alpha-L-fucosidases. Synthesis and glycosidase inhibitory activities of [(2R,3S,4R)-3,4-dihydroxypyrrolidin-2-yl]furan derivatives. (PMID: 11549468) Robina I. … Vogel P. (Bioorg. Med. Chem. Lett. 2001) 3 23

Products for FUCA1 Gene

Sources for FUCA1 Gene

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