FUBP3 Gene
protein-coding GIFtS: 50
GCID: GC09P133454
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far upstream element (FUSE) binding protein 3
(Previous symbol: FBP3)
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Aliases
for FUBP3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Far Upstream Element (FUSE) Binding Protein 31 2 | | FBP31 2 3 | | FUSE-Binding Protein 32 3 | | Far Upstream Element-Binding Protein 32 |
Export aliases for FUBP3 gene to outside databasesPrevious GC identifers: GC09P124470 GC09P125001 GC09P126809 GC09P128746 GC09P128730 GC09U900642 GC09P132444 GC09P102941 |
Summaries
for FUBP3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FUBP3_HUMAN, Q96I24Function: May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression
|
Genomic Views
for FUBP3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FUBP3 gene promoter:
NF-1 NF-1/L AML1a p300 Egr-1 Olf-1 MIF-1 AREB6 Cart-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FUBP3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUBP3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34.11 Ensembl cytogenetic band: 9q34.11 HGNC cytogenetic band: 9q34.11FUBP3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P133454: view genomic region
(about GC identifiers)
Start:
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133,454,352 bp from pter |
End:
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133,513,739 bp from pter |
Size:
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59,388 bases |
Orientation:
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plus strand |
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Proteins
for FUBP3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FUBP3_HUMAN, Q96I24 (See
protein sequence)Recommended Name: Far upstream element-binding protein 3 Size: 572 amino acids; 61640 Da
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=AAC50893.1; Type=Frameshift; Positions=18; Sequence=AAH01325.1; Type=Frameshift;Positions=527;
Secondary accessions: A3KFK8 A3KFL0 Q92946 Q9BVB6Alternative splicing: 2 isoforms: Q96I24-1 Q96I24-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FUBP3: NX_Q96I24
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96I24
FUBP3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003925.1
ENSEMBL proteins: ENSP00000318177 ENSP00000361451
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
FUBP3 for ontologies About GeneDecksing
FUBP3 Antibody Products:
Assay Products for FUBP3: |
Protein
Domains /
Families
for FUBP3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FUBP3 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96I24ProtoNet protein and cluster: Q96I24 1 Blocks protein family: IPB004088 KH
UniProtKB/Swiss-Prot: FUBP3_HUMAN, Q96I24Similarity: Contains 4 KH domains |
Function
for FUBP3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FUBP3_HUMAN, Q96I24Function: May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUBP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUBP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: FUBP3 (NM_003934) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUBP3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUBP3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUBP3 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
FUBP3 for ontologies About GeneDecksing
|
Pathways & Interactions
for FUBP3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FUBP3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/20 Interacting proteins for FUBP3 (Q96I243 ENSP000003181774) via UniProtKB, MINT, STRING, and/or I2D (see all 20)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
FUBP3 for ontologies About GeneDecksing
|
Drugs & Compounds
for FUBP3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FUBP3
Search CenterWatch for drugs/clinical trials and news about FUBP3
|
Transcripts
for FUBP3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FUBP3 gene: NM_003934.1 Unigene Clusters for FUBP3: Far upstream element (FUSE) binding protein 3 Hs.98751 [show with all ESTs], Hs.673029 [show with all ESTs]Unigene Representative Sequences: NM_003934, BC0151847 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000467100(uc004bzq.1) ENST00000319725(uc004bzr.1) ENST00000372376(uc010mzd.1)
ENST00000465949 ENST00000487406 ENST00000472006 ENST00000492199
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUBP3 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUBP3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FUBP3 (NM_003934) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FUBP3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUBP3 |
Additional cDNA sequence: BC015184.1 BC041566.1 11 DOTS entries: DT.112637 DT.106564 DT.91699635 DT.97795305 DT.100778504 DT.121166616 DT.121166605 DT.91650046 DT.91703642 DT.91748980 DT.91957087
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for FUBP3 (see all 6) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 |
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FUBP3
|
Expression
for FUBP3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FUBP3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGTTTTTAA
About this image
See FUBP3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FUBP3
SOURCE GeneReport for Unigene clusters: Hs.98751 Hs.673029
UniProtKB/Swiss-Prot: FUBP3_HUMAN, Q96I24Tissue specificity: Detected in a number of cell lines
SABiosciences Custom PCR Arrays for FUBP3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUBP3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FUBP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUBP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUBP3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUBP3 |
Orthologs
for FUBP3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for FUBP3 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for FUBP3 (if available)
TreeFam Gene Tree for FUBP3 (if available) |
Paralogs
for FUBP3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FUBP3 gene
- FUBP12 PCBP42 HNRNPK2 KHSRP2 PCBP32 PCBP22 NOVA22 PCBP12
- NOVA12
4 SIMAP similar genes for FUBP3 using alignment to 1 protein entry: FUBP3_HUMAN:FUBP1 KHSRP NOVA1 PCBP2
FUBP3 for paralogs About GeneDecksing
|
Genomic Variants
for FUBP3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FUBP3 (133454352 - 133513739 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FUBP3: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUBP3 |
|
Disorders
/ Diseases
for FUBP3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FUBP3 for disorders About GeneDecksing
OMIM gene information: 603536
OMIM disorders: --
3  diseases for FUBP3: About MalaCardsataxia malaria prostatitis
Human Genome Epidemiology (HuGE) Navigator: FUBP3 (1 document)
Export disorders for FUBP3 gene to outside databases
|
Publications
for FUBP3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FUBP3 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with FUBP3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. (PubMed id 8940189)1, 2, 3 Davis-Smyth T....Levens D. (1996)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. (PubMed id 19087307)1, 9 Weber A....Kristiansen G. (2008)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)
- A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
- Maintenance of silent chromatin through replication r equires SWI/SNF-like chromatin remodeler SMARCAD1. (PubMed id 21549307)1 Rowbotham S.P....Mermoud J.E. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for FUBP3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FUBP3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FUBP3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FUBP3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FUBP3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FUBP3 gene:
Search GeneIP for patents involving FUBP3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FUBP3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FUBP3 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FUBP3 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FUBP3 | | | OriGene Protein Over-expression Lysate for FUBP3 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FUBP3 | | OriGene 3'-UTR Clone for FUBP3 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FUBP3 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FUBP3 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FUBP3 | | OriGene Custom Protein Services for FUBP3 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FUBP3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FUBP3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FUBP3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FUBP3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FUBP3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FUBP3 |
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 |  |  |  | |
| | | | Search Tocris compounds for FUBP3 |
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 | | | FUBP3 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FUBP3 |
|  |  |  | | | | ThermoFisher Antibodies for FUBP3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FUBP3 |
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