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Aliases for FUBP3 Gene

Aliases for FUBP3 Gene

  • Far Upstream Element Binding Protein 3 2 3 5
  • Far Upstream Element (FUSE) Binding Protein 3 2 3
  • FUSE-Binding Protein 3 3 4
  • FBP3 3 4
  • Far Upstream Element-Binding Protein 3 3

External Ids for FUBP3 Gene

Previous HGNC Symbols for FUBP3 Gene

  • FBP3

Previous GeneCards Identifiers for FUBP3 Gene

  • GC09P124470
  • GC09P125001
  • GC09P126809
  • GC09P128746
  • GC09P128730
  • GC09U900642
  • GC09P132444
  • GC09P133454
  • GC09P102941

Summaries for FUBP3 Gene

GeneCards Summary for FUBP3 Gene

FUBP3 (Far Upstream Element Binding Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is FUBP1.

UniProtKB/Swiss-Prot for FUBP3 Gene

  • May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

Additional gene information for FUBP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUBP3 Gene

Genomics for FUBP3 Gene

GeneHancer (GH) Regulatory Elements for FUBP3 Gene

Promoters and enhancers for FUBP3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I130578 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.6 593 2.6 CLOCK SMAD1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF207 FUBP3 LOC100272217 GC09P130566
GH09I129605 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 26 -970.0 -969974 5.8 CLOCK FEZF1 DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF548 MCM3 SP3 NTMT1 NUP188 LOC101929314 SPOUT1 FUBP3 PKN3 C9orf50 NCS1 MIGA2 USP20
GH09I129623 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.7 -952.1 -952133 6.7 PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B NTMT1 NUP188 FUBP3 PKN3 SPOUT1 PRRX2 TOR1B ENSG00000234055 LOC101929314 C9orf50
GH09I130444 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.6 -130.3 -130346 8.4 PKNOX1 FOXA2 CLOCK MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ASS1 NUP214 EXOSC2 ENSG00000246851 FUBP3 TOR1B ENSG00000236986 GC09M130482
GH09I131282 Enhancer 1.2 Ensembl ENCODE dbSUPER 27.9 +704.2 704198 1.4 NFIB ZSCAN4 INSM2 NEUROD1 SIN3A YBX1 GLI4 ZBTB7B ZEB1 GLIS2 FAM78A FUBP3 NUP214 ENSG00000246851 PRRC2B EXOSC2 PLPP7 POMT1 ENSG00000236986 GC09P131226
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FUBP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUBP3 gene promoter:

Genomic Locations for FUBP3 Gene

Genomic Locations for FUBP3 Gene
chr9:130,578,857-130,638,352
(GRCh38/hg38)
Size:
59,496 bases
Orientation:
Plus strand
chr9:133,454,352-133,513,739
(GRCh37/hg19)

Genomic View for FUBP3 Gene

Genes around FUBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUBP3 Gene

Proteins for FUBP3 Gene

  • Protein details for FUBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I24-FUBP3_HUMAN
    Recommended name:
    Far upstream element-binding protein 3
    Protein Accession:
    Q96I24
    Secondary Accessions:
    • A3KFK8
    • A3KFL0
    • Q92946
    • Q9BVB6

    Protein attributes for FUBP3 Gene

    Size:
    572 amino acids
    Molecular mass:
    61640 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50893.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=AAH01325.1; Type=Frameshift; Positions=527; Evidence={ECO:0000305};

    Alternative splice isoforms for FUBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUBP3 Gene

Post-translational modifications for FUBP3 Gene

  • Ubiquitination at isoforms=57, posLast=8787, and posLast=378378

No data available for DME Specific Peptides for FUBP3 Gene

Domains & Families for FUBP3 Gene

Gene Families for FUBP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FUBP3 Gene

Suggested Antigen Peptide Sequences for FUBP3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FUBP3: view

No data available for UniProtKB/Swiss-Prot for FUBP3 Gene

Function for FUBP3 Gene

Molecular function for FUBP3 Gene

UniProtKB/Swiss-Prot Function:
May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

Phenotypes From GWAS Catalog for FUBP3 Gene

Gene Ontology (GO) - Molecular Function for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 8940189
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 8940189
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA,HDA 22658674
genes like me logo Genes that share ontologies with FUBP3: view
genes like me logo Genes that share phenotypes with FUBP3: view

Animal Model Products

CRISPR Products

miRNA for FUBP3 Gene

miRTarBase miRNAs that target FUBP3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUBP3 Gene

Localization for FUBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUBP3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUBP3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8940189
GO:0005737 cytoplasm IDA 19087307
GO:0016020 membrane IDA,HDA 19946888
genes like me logo Genes that share ontologies with FUBP3: view

Pathways & Interactions for FUBP3 Gene

SuperPathways for FUBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA,IEA 8940189
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0010628 positive regulation of gene expression IDA 19087307
GO:0045893 positive regulation of transcription, DNA-templated IDA 8940189
genes like me logo Genes that share ontologies with FUBP3: view

No data available for Pathways by source and SIGNOR curated interactions for FUBP3 Gene

Drugs & Compounds for FUBP3 Gene

No Compound Related Data Available

Transcripts for FUBP3 Gene

mRNA/cDNA for FUBP3 Gene

(11) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUBP3 Gene

Far upstream element (FUSE) binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for FUBP3 Gene

GeneLoc Exon Structure for
FUBP3
ECgene alternative splicing isoforms for
FUBP3

Expression for FUBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUBP3 Gene

This gene is overexpressed in Breast (43.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUBP3 Gene



Protein tissue co-expression partners for FUBP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FUBP3 Gene:

FUBP3

SOURCE GeneReport for Unigene cluster for FUBP3 Gene:

Hs.98751

mRNA Expression by UniProt/SwissProt for FUBP3 Gene:

Q96I24-FUBP3_HUMAN
Tissue specificity: Detected in a number of cell lines.

Evidence on tissue expression from TISSUES for FUBP3 Gene

  • Nervous system(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with FUBP3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUBP3 Gene

Orthologs for FUBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUBP3 33 34
  • 99.83 (n)
cow
(Bos Taurus)
Mammalia FUBP3 33 34
  • 90.5 (n)
oppossum
(Monodelphis domestica)
Mammalia FUBP3 34
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fubp3 33
  • 89.16 (n)
mouse
(Mus musculus)
Mammalia Fubp3 33 16 34
  • 88.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FUBP3 34
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUBP3 33 34
  • 83.8 (n)
chicken
(Gallus gallus)
Aves FUBP3 33 34
  • 84.26 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fubp3 33
  • 78.41 (n)
zebrafish
(Danio rerio)
Actinopterygii fubp3 33 34
  • 71.01 (n)
CABZ01073334.1 34
  • 71 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Psi 33 34
  • 48.12 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_C12D8.1 33
  • 47.92 (n)
C12D8.1a 35
  • 36 (a)
C12D8.1b 35
  • 36 (a)
C36E6.1a 35
  • 34 (a)
C36E6.1b 35
  • 34 (a)
M01A10.1 35 34
  • 32 (a)
ZK418.9 35 34
  • 30 (a)
C12D8.1 34
  • 26 (a)
ManyToMany
C36E6.1 34
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
ManyToMany
-- 34
  • 32 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
Species where no ortholog for FUBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUBP3 Gene

ENSEMBL:
Gene Tree for FUBP3 (if available)
TreeFam:
Gene Tree for FUBP3 (if available)

Paralogs for FUBP3 Gene

Paralogs for FUBP3 Gene

(4) SIMAP similar genes for FUBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUBP3: view

Variants for FUBP3 Gene

Sequence variations from dbSNP and Humsavar for FUBP3 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000006511 -- 130,621,920(+) A/G intron_variant
rs1000007291 -- 130,629,444(+) G/A intron_variant
rs1000022754 -- 130,634,645(+) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000027999 -- 130,589,216(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000045265 -- 130,595,664(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FUBP3 Gene

Variant ID Type Subtype PubMed ID
dgv7718n100 CNV gain 25217958
dgv7719n100 CNV gain 25217958
dgv7720n100 CNV gain 25217958
esv1002669 CNV gain 20482838
nsv1041989 CNV gain 25217958
nsv1054840 CNV gain 25217958
nsv825121 CNV gain 20364138
nsv825122 CNV gain 20364138
nsv831734 CNV gain 17160897
nsv831735 CNV loss 17160897

Variation tolerance for FUBP3 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUBP3 Gene

Disorders for FUBP3 Gene

Additional Disease Information for FUBP3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FUBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUBP3 Gene

Publications for FUBP3 Gene

  1. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. (PMID: 8940189) Davis-Smyth T … Levens D (The Journal of biological chemistry 1996) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 44 58
  4. Identification of ten loci associated with height highlights new biological pathways in human growth. (PMID: 18391950) Lettre G … Hirschhorn JN (Nature genetics 2008) 3 44 58
  5. The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. (PMID: 19087307) Weber A … Kristiansen G (BMC cancer 2008) 3 22 58

Products for FUBP3 Gene

Sources for FUBP3 Gene

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