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Aliases for FUBP3 Gene

Aliases for FUBP3 Gene

  • Far Upstream Element Binding Protein 3 2 3
  • Far Upstream Element (FUSE) Binding Protein 3 2 3 5
  • FUSE-Binding Protein 3 3 4
  • FBP3 3 4

External Ids for FUBP3 Gene

Previous HGNC Symbols for FUBP3 Gene

  • FBP3

Previous GeneCards Identifiers for FUBP3 Gene

  • GC09P124470
  • GC09P125001
  • GC09P126809
  • GC09P128746
  • GC09P128730
  • GC09U900642
  • GC09P132444
  • GC09P133454
  • GC09P102941

Summaries for FUBP3 Gene

GeneCards Summary for FUBP3 Gene

FUBP3 (Far Upstream Element Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is KHSRP.

UniProtKB/Swiss-Prot for FUBP3 Gene

  • May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUBP3 Gene

Genomics for FUBP3 Gene

Regulatory Elements for FUBP3 Gene

Promoters for FUBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FUBP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for FUBP3 Gene

Chromosome:
9
Start:
130,578,857 bp from pter
End:
130,638,352 bp from pter
Size:
59,496 bases
Orientation:
Plus strand

Genomic View for FUBP3 Gene

Genes around FUBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUBP3 Gene

Proteins for FUBP3 Gene

  • Protein details for FUBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I24-FUBP3_HUMAN
    Recommended name:
    Far upstream element-binding protein 3
    Protein Accession:
    Q96I24
    Secondary Accessions:
    • A3KFK8
    • A3KFL0
    • Q92946
    • Q9BVB6

    Protein attributes for FUBP3 Gene

    Size:
    572 amino acids
    Molecular mass:
    61640 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC50893.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=AAH01325.1; Type=Frameshift; Positions=527; Evidence={ECO:0000305};

    Alternative splice isoforms for FUBP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUBP3 Gene

Proteomics data for FUBP3 Gene at MOPED

Post-translational modifications for FUBP3 Gene

  • Ubiquitination at Lys 57, Lys 87, and Lys 378
  • Modification sites at PhosphoSitePlus

Other Protein References for FUBP3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for FUBP3 Gene

Domains & Families for FUBP3 Gene

Protein Domains for FUBP3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for FUBP3 Gene

Graphical View of Domain Structure for InterPro Entry

Q96I24

UniProtKB/Swiss-Prot:

FUBP3_HUMAN :
  • Contains 4 KH domains.
Domain:
  • Contains 4 KH domains.
genes like me logo Genes that share domains with FUBP3: view

No data available for Gene Families for FUBP3 Gene

Function for FUBP3 Gene

Molecular function for FUBP3 Gene

UniProtKB/Swiss-Prot Function:
May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

Gene Ontology (GO) - Molecular Function for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 8940189
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with FUBP3: view
genes like me logo Genes that share phenotypes with FUBP3: view

Animal Model Products

CRISPR Products

miRNA for FUBP3 Gene

miRTarBase miRNAs that target FUBP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUBP3 Gene

Localization for FUBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUBP3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUBP3 Gene COMPARTMENTS Subcellular localization image for FUBP3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

No data available for Gene Ontology (GO) - Cellular Components for FUBP3 Gene

Pathways & Interactions for FUBP3 Gene

SuperPathways for FUBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 8940189
genes like me logo Genes that share ontologies with FUBP3: view

No data available for Pathways by source and SIGNOR curated interactions for FUBP3 Gene

Drugs & Compounds for FUBP3 Gene

No Compound Related Data Available

Transcripts for FUBP3 Gene

mRNA/cDNA for FUBP3 Gene

(9) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUBP3 Gene

Far upstream element (FUSE) binding protein 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FUBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP1:
SP2: - -
SP3: - - -
SP4: - -
SP5: - -
SP6:

Relevant External Links for FUBP3 Gene

GeneLoc Exon Structure for
FUBP3
ECgene alternative splicing isoforms for
FUBP3

Expression for FUBP3 Gene

mRNA expression in normal human tissues for FUBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUBP3 Gene

This gene is overexpressed in Breast (43.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUBP3 Gene



SOURCE GeneReport for Unigene cluster for FUBP3 Gene Hs.98751

mRNA Expression by UniProt/SwissProt for FUBP3 Gene

Q96I24-FUBP3_HUMAN
Tissue specificity: Detected in a number of cell lines.
genes like me logo Genes that share expression patterns with FUBP3: view

Protein tissue co-expression partners for FUBP3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for FUBP3 Gene

Orthologs for FUBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUBP3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUBP3 36
  • 100 (a)
OneToOne
FUBP3 35
  • 99.83 (n)
  • 99.83 (a)
cow
(Bos Taurus)
Mammalia FUBP3 36
  • 95 (a)
OneToOne
FUBP3 35
  • 90.5 (n)
  • 95.1 (a)
dog
(Canis familiaris)
Mammalia FUBP3 35
  • 83.8 (n)
  • 85.96 (a)
FUBP3 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fubp3 35
  • 88.83 (n)
  • 93.47 (a)
Fubp3 16
Fubp3 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FUBP3 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUBP3 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fubp3 35
  • 89.16 (n)
  • 93.15 (a)
chicken
(Gallus gallus)
Aves FUBP3 35
  • 84.26 (n)
  • 90.02 (a)
FUBP3 36
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fubp3 35
  • 78.41 (n)
  • 85.14 (a)
zebrafish
(Danio rerio)
Actinopterygii fubp3 35
  • 71.01 (n)
  • 73.74 (a)
CABZ01073334.1 36
  • 71 (a)
OneToMany
fubp3 36
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Psi 36
  • 21 (a)
OneToMany
Psi 35
  • 48.12 (n)
  • 41.06 (a)
worm
(Caenorhabditis elegans)
Secernentea C12D8.1 36
  • 26 (a)
ManyToMany
C36E6.1 36
  • 24 (a)
ManyToMany
M01A10.1 36
  • 23 (a)
ManyToMany
ZK418.9 36
  • 25 (a)
ManyToMany
C12D8.1a 37
  • 36 (a)
C12D8.1b 37
  • 36 (a)
C36E6.1a 37
  • 34 (a)
C36E6.1b 37
  • 34 (a)
M01A10.1 37
  • 32 (a)
ZK418.9 37
  • 30 (a)
CELE_C12D8.1 35
  • 47.92 (n)
  • 42.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
-- 36
  • 32 (a)
ManyToMany
Species with no ortholog for FUBP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUBP3 Gene

ENSEMBL:
Gene Tree for FUBP3 (if available)
TreeFam:
Gene Tree for FUBP3 (if available)

Paralogs for FUBP3 Gene

Paralogs for FUBP3 Gene

(4) SIMAP similar genes for FUBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUBP3: view

Variants for FUBP3 Gene

Sequence variations from dbSNP and Humsavar for FUBP3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs750663 -- 130,636,461(-) TTGCT(C/T)CTTTA intron-variant, downstream-variant-500B
rs750664 -- 130,636,455(-) CTTTA(C/T)GGTTA intron-variant, downstream-variant-500B
rs750665 -- 130,636,370(-) TCAGG(C/G)ACTTC intron-variant, downstream-variant-500B
rs1835727 -- 130,610,702(-) CAACA(A/G)ATACA intron-variant
rs2567694 -- 130,612,662(-) TTTCA(A/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUBP3 Gene

Variant ID Type Subtype PubMed ID
nsv831734 CNV Gain 17160897
nsv831735 CNV Loss 17160897
esv1002669 CNV Gain 20482838
nsv825121 CNV Gain 20364138
nsv825122 CNV Gain 20364138

Variation tolerance for FUBP3 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUBP3 Gene

HapMap Linkage Disequilibrium report
FUBP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUBP3 Gene

Disorders for FUBP3 Gene

Relevant External Links for FUBP3

Genetic Association Database (GAD)
FUBP3
Human Genome Epidemiology (HuGE) Navigator
FUBP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUBP3

No disorders were found for FUBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUBP3 Gene

Publications for FUBP3 Gene

  1. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. (PMID: 8940189) Davis-Smyth T. … Levens D. (J. Biol. Chem. 1996) 2 3 4 67
  2. The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. (PMID: 19087307) Weber A. … Kristiansen G. (BMC Cancer 2008) 3 23
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) KAorblane K. … Sarmiento C. (PLoS ONE 2015) 3
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for FUBP3 Gene

Sources for FUBP3 Gene

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