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Aliases for FUBP3 Gene

Aliases for FUBP3 Gene

  • Far Upstream Element Binding Protein 3 2 3 5
  • Far Upstream Element (FUSE) Binding Protein 3 2 3
  • FUSE-Binding Protein 3 3 4
  • FBP3 3 4
  • Far Upstream Element-Binding Protein 3 3

External Ids for FUBP3 Gene

Previous HGNC Symbols for FUBP3 Gene

  • FBP3

Previous GeneCards Identifiers for FUBP3 Gene

  • GC09P124470
  • GC09P125001
  • GC09P126809
  • GC09P128746
  • GC09P128730
  • GC09U900642
  • GC09P132444
  • GC09P133454
  • GC09P102941

Summaries for FUBP3 Gene

GeneCards Summary for FUBP3 Gene

FUBP3 (Far Upstream Element Binding Protein 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is FUBP1.

UniProtKB/Swiss-Prot for FUBP3 Gene

  • May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

Additional gene information for FUBP3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUBP3 Gene

Genomics for FUBP3 Gene

Regulatory Elements for FUBP3 Gene

Enhancers for FUBP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09H129605 1.8 FANTOM5 ENCODE dbSUPER 34 -970.0 -969975 5.8 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 SP3 MCM3 ZFP41 SSRP1 NUP188 LOC101929314 FUBP3 SPOUT1 PKN3 C9orf50 UBE2V1P4 NCS1 MIGA2 USP20
GH09H131282 1.4 Ensembl ENCODE dbSUPER 35.8 +704.2 704198 1.4 NFIB ZSCAN4 INSM2 SIN3A YBX1 GLI4 ZBTB7B ZEB1 GLIS2 ZNF391 FUBP3 NUP214 ENSG00000246851 PRRC2B EXOSC2 PLPP7 POMT1 ABL1 ENSG00000236986 FAM78A
GH09H129623 1.7 FANTOM5 ENCODE dbSUPER 24.7 -952.1 -952133 6.7 PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 DEK NUP188 SPOUT1 FUBP3 PKN3 PRRX2 TOR1B ENSG00000234055 LOC101929314 NTMT1 C9orf50
GH09H129594 2 FANTOM5 Ensembl ENCODE dbSUPER 15.6 -982.0 -981953 3.8 HDGF PKNOX1 MLX ARNT ARID4B DMAP1 SLC30A9 ZNF766 ZNF143 ZNF207 FUBP3 PKN3 NUP188 PTPA IER5L CRAT NTMT1 ASB6 PTGES LOC105376292
GH09H129756 1.1 FANTOM5 Ensembl 27.9 -821.4 -821418 1 ZNF493 ZNF140 ZNF223 ZNF266 ZNF514 ZNF697 ZNF664 ZNF138 PRDM10 ZNF433 NUP188 EXOSC2 SPOUT1 FUBP3 LOC101929314 ABL1 TOR1B DOLK PTGES FNBP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FUBP3 on UCSC Golden Path with GeneCards custom track

Promoters for FUBP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000242223 643 1801 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF207 ZNF143 FOS DEK

Genomic Locations for FUBP3 Gene

Genomic Locations for FUBP3 Gene
59,496 bases
Plus strand

Genomic View for FUBP3 Gene

Genes around FUBP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUBP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUBP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUBP3 Gene

Proteins for FUBP3 Gene

  • Protein details for FUBP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Far upstream element-binding protein 3
    Protein Accession:
    Secondary Accessions:
    • A3KFK8
    • A3KFL0
    • Q92946
    • Q9BVB6

    Protein attributes for FUBP3 Gene

    572 amino acids
    Molecular mass:
    61640 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAC50893.1; Type=Frameshift; Positions=18; Evidence={ECO:0000305}; Sequence=AAH01325.1; Type=Frameshift; Positions=527; Evidence={ECO:0000305};

    Alternative splice isoforms for FUBP3 Gene


neXtProt entry for FUBP3 Gene

Post-translational modifications for FUBP3 Gene

  • Ubiquitination at posLast=5757, isoforms=287, and isoforms=378
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FUBP3 Gene

Domains & Families for FUBP3 Gene

Gene Families for FUBP3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FUBP3 Gene


Suggested Antigen Peptide Sequences for FUBP3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FUBP3: view

No data available for UniProtKB/Swiss-Prot for FUBP3 Gene

Function for FUBP3 Gene

Molecular function for FUBP3 Gene

UniProtKB/Swiss-Prot Function:
May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression.

Phenotypes From GWAS Catalog for FUBP3 Gene

Gene Ontology (GO) - Molecular Function for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 8940189
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 8940189
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FUBP3: view
genes like me logo Genes that share phenotypes with FUBP3: view

Animal Model Products

CRISPR Products

miRNA for FUBP3 Gene

miRTarBase miRNAs that target FUBP3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FUBP3 Gene

Localization for FUBP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUBP3 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUBP3 gene
Compartment Confidence
nucleus 5
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 8940189
GO:0005737 cytoplasm IDA 19087307
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with FUBP3: view

Pathways & Interactions for FUBP3 Gene

SuperPathways for FUBP3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUBP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IDA,IEA 8940189
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0010628 positive regulation of gene expression IDA 19087307
GO:0045893 positive regulation of transcription, DNA-templated IDA 8940189
genes like me logo Genes that share ontologies with FUBP3: view

No data available for Pathways by source and SIGNOR curated interactions for FUBP3 Gene

Drugs & Compounds for FUBP3 Gene

No Compound Related Data Available

Transcripts for FUBP3 Gene

mRNA/cDNA for FUBP3 Gene

(11) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FUBP3 Gene

Far upstream element (FUSE) binding protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUBP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21
SP2: - -
SP3: - - -
SP4: - -
SP5: - -

Relevant External Links for FUBP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FUBP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUBP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FUBP3 Gene

This gene is overexpressed in Breast (43.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUBP3 Gene

Protein tissue co-expression partners for FUBP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FUBP3 Gene:


SOURCE GeneReport for Unigene cluster for FUBP3 Gene:


mRNA Expression by UniProt/SwissProt for FUBP3 Gene:

Tissue specificity: Detected in a number of cell lines.

Evidence on tissue expression from TISSUES for FUBP3 Gene

  • Nervous system(4.4)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with FUBP3: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUBP3 Gene

Orthologs for FUBP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUBP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FUBP3 33 34
  • 99.83 (n)
(Bos Taurus)
Mammalia FUBP3 33 34
  • 90.5 (n)
(Monodelphis domestica)
Mammalia FUBP3 34
  • 90 (a)
(Rattus norvegicus)
Mammalia Fubp3 33
  • 89.16 (n)
(Mus musculus)
Mammalia Fubp3 33 16 34
  • 88.83 (n)
(Ornithorhynchus anatinus)
Mammalia FUBP3 34
  • 85 (a)
(Canis familiaris)
Mammalia FUBP3 33 34
  • 83.8 (n)
(Gallus gallus)
Aves FUBP3 33 34
  • 84.26 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia fubp3 33
  • 78.41 (n)
(Danio rerio)
Actinopterygii fubp3 33 34
  • 71.01 (n)
CABZ01073334.1 34
  • 71 (a)
fruit fly
(Drosophila melanogaster)
Insecta Psi 33 34
  • 48.12 (n)
(Caenorhabditis elegans)
Secernentea CELE_C12D8.1 33
  • 47.92 (n)
C12D8.1a 35
  • 36 (a)
C12D8.1b 35
  • 36 (a)
C36E6.1a 35
  • 34 (a)
C36E6.1b 35
  • 34 (a)
M01A10.1 35 34
  • 32 (a)
ZK418.9 35 34
  • 30 (a)
C12D8.1 34
  • 26 (a)
C36E6.1 34
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
-- 34
  • 32 (a)
-- 34
  • 21 (a)
Species where no ortholog for FUBP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUBP3 Gene

Gene Tree for FUBP3 (if available)
Gene Tree for FUBP3 (if available)

Paralogs for FUBP3 Gene

Paralogs for FUBP3 Gene

(4) SIMAP similar genes for FUBP3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FUBP3: view

Variants for FUBP3 Gene

Sequence variations from dbSNP and Humsavar for FUBP3 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000006511 -- 130,621,920(+) AAAAA(A/G)AAAAG intron-variant
rs1000007291 -- 130,629,444(+) TAAGG(A/G)CAGCC intron-variant
rs1000022754 -- 130,634,645(+) CTGAC(C/T)GCTTT intron-variant, nc-transcript-variant, downstream-variant-500B
rs1000027999 -- 130,589,216(+) GAAAA(C/T)GTGTA intron-variant
rs1000045265 -- 130,595,664(+) CATTA(C/G)CTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUBP3 Gene

Variant ID Type Subtype PubMed ID
nsv831735 CNV loss 17160897
nsv831734 CNV gain 17160897
nsv825122 CNV gain 20364138
nsv825121 CNV gain 20364138
nsv1054840 CNV gain 25217958
nsv1041989 CNV gain 25217958
esv1002669 CNV gain 20482838
dgv7720n100 CNV gain 25217958
dgv7719n100 CNV gain 25217958
dgv7718n100 CNV gain 25217958

Variation tolerance for FUBP3 Gene

Residual Variation Intolerance Score: 17.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUBP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUBP3 Gene

Disorders for FUBP3 Gene

Relevant External Links for FUBP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FUBP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FUBP3 Gene

Publications for FUBP3 Gene

  1. The far upstream element-binding proteins comprise an ancient family of single-strand DNA-binding transactivators. (PMID: 8940189) Davis-Smyth T … Levens D (The Journal of biological chemistry 1996) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H … Hirschhorn JN (Nature 2010) 3 45 60
  4. Identification of ten loci associated with height highlights new biological pathways in human growth. (PMID: 18391950) Lettre G … Hirschhorn JN (Nature genetics 2008) 3 45 60
  5. The FUSE binding proteins FBP1 and FBP3 are potential c-myc regulators in renal, but not in prostate and bladder cancer. (PMID: 19087307) Weber A … Kristiansen G (BMC cancer 2008) 3 22 60

Products for FUBP3 Gene

Sources for FUBP3 Gene

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