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FUBP1 Gene

protein-coding   GIFtS: 58
GCID: GC01M078400

Far Upstream Element (FUSE) Binding Protein 1


(Previous symbol: FUBP)
  See FUBP1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Far Upstream Element (FUSE) Binding Protein 11 2     HDH V2 3
FUBP1 2 5     Far Upstream Element-Binding Protein 12
FBP2 3 5     FUSE-Binding Protein 13
DNA Helicase V2 3     

External Ids:    HGNC: 40041   Entrez Gene: 88802   Ensembl: ENSG000001626137   OMIM: 6034445   UniProtKB: Q96AE43   

Export aliases for FUBP1 gene to outside databases

Previous GC identifers: GC01M078564 GC01M077358 GC01M077800 GC01M077834 GC01M078124 GC01M076545


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FUBP1 Gene:
This gene encodes a ssDNA binding protein that activates the far upstream element (FUSE) of c-myc and stimulates
expression of c-myc in undifferentiated cells. Regulation of FUSE by FUBP occurs through single-strand binding of
FUBP to the non-coding strand. This protein has been shown to function as an ATP-dependent DNA helicase.
(provided by RefSeq, Jul 2008)

GeneCards Summary for FUBP1 Gene:
FUBP1 (far upstream element (FUSE) binding protein 1) is a protein-coding gene. Diseases associated with FUBP1 include oligoastrocytoma. GO annotations related to this gene include single-stranded DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is KHSRP.

UniProtKB/Swiss-Prot: FUBP1_HUMAN, Q96AE4
Function: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC
promoter. May act both as activator and repressor of transcription

Gene Wiki entry for FUBP1 (Far upstream element-binding protein 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FUBP1 gene promoter:
         E2F   E2F-1   AP-1   ATF-2   Msx-1   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFUBP1 promoter sequence
   Search Chromatin IP Primers for FUBP1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FUBP1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p31.1   Ensembl cytogenetic band:  1p31.1   HGNC cytogenetic band: 1p31.1

FUBP1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FUBP1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M078400:  view genomic region     (about GC identifiers)

Start:
78,409,740 bp from pter      End:
78,444,794 bp from pter
Size:
35,055 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FUBP1_HUMAN, Q96AE4 (See protein sequence)
Recommended Name: Far upstream element-binding protein 1  
Size: 644 amino acids; 67560 Da
Subunit: Found in a complex with PUF60 and far upstream element (FUSE) DNA segment. Interacts with PUF60 and JTV1
3 PDB 3D structures from and Proteopedia for FUBP1:
1J4W (3D)        2KXH (3D)        4LIJ (3D)    
Secondary accessions: Q12828
Alternative splicing: 2 isoforms:  Q96AE4-1   Q96AE4-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FUBP1: NX_Q96AE4

Explore proteomics data for FUBP1 at MOPED

Post-translational modifications: 

  • Ubiquitinated. This targets the protein for proteasome-mediated degradation1
  • Ubiquitination2 at Lys64, Lys209, Lys312, Lys425
  • Modification sites at PhosphoSitePlus

  • See FUBP1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003893.2  
    ENSEMBL proteins: 
     ENSP00000294623   ENSP00000359804   ENSP00000359803   ENSP00000402630   ENSP00000389536  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR004087 KH_dom
     IPR015096 DUF1897
     IPR004088 KH_dom_type_1

    Graphical View of Domain Structure for InterPro Entry Q96AE4

    ProtoNet protein and cluster: Q96AE4

    2 Blocks protein domains:
    IPB004088 KH
    IPB008160 Collagen triple helix repeat


    UniProtKB/Swiss-Prot: FUBP1_HUMAN, Q96AE4
    Similarity: Contains 4 KH domains


    Find genes that share domains with FUBP1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FUBP1_HUMAN, Q96AE4
    Function: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC
    promoter. May act both as activator and repressor of transcription

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003697single-stranded DNA binding TAS8125259
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8125259
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI--
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with FUBP1           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for FUBP1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for FUBP1

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    miRTarBase miRNAs that target FUBP1:
    hsa-mir-1 (MIRT023618), hsa-mir-222-3p (MIRT046588), hsa-mir-21-5p (MIRT030728), hsa-mir-215-5p (MIRT024616), hsa-mir-324-3p (MIRT042947), hsa-mir-192-5p (MIRT026246), hsa-mir-22-3p (MIRT050458), hsa-mir-615-3p (MIRT039813), hsa-mir-155-5p (MIRT020591)

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    Selected qRT-PCR Assays for microRNAs that regulate FUBP1 (see all 53):
    hsa-miR-579 hsa-miR-607 hsa-miR-429 hsa-miR-15a hsa-miR-548k hsa-miR-199a-3p hsa-miR-1245 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidFUBP1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FUBP1_HUMAN, Q96AE4: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with FUBP1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FUBP1
    Interactions:

        GeneGlobe Interaction Network for FUBP1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FUBP1 (Q96AE41, 2, 3 ENSP000003598044) via UniProtKB, MINT, STRING, and/or I2D (see all 639)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AIMP2Q131551, 2, 3, ENSP000002230294EBI-711404,EBI-745226 MINT-8145530 MINT-8145585 MINT-8145599 I2D: score=3 STRING: ENSP00000223029
    SMN1Q166372, 3, ENSP000003700834MINT-7945693 I2D: score=3 STRING: ENSP00000370083
    SMN2Q166372, 3, ENSP000003701194MINT-7945693 I2D: score=3 STRING: ENSP00000370119
    USP22Q9UPT91, 2EBI-711404,EBI-723510 MINT-8297408 MINT-8297418 MINT-8298193
    CHD3Q128732, 3MINT-7945693 MINT-65111 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366transcription from RNA polymerase II promoter TAS8125259
    GO:0010628positive regulation of gene expression IDA19087307

    Find genes that share ontologies with FUBP1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FUBP1

    1 Novoseek inferred chemical compound relationship for FUBP1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 0.0441 1 11222755 (1)



    Find genes that share compounds with FUBP1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FUBP1 gene: 
    NM_003902.3  

    Unigene Cluster for FUBP1:

    Far upstream element (FUSE) binding protein 1
    Hs.567380  [show with all ESTs]
    Unigene Representative Sequence: AB209366
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000483894 ENST00000480673 ENST00000474632 ENST00000489495 ENST00000488814
    ENST00000492405 ENST00000492724 ENST00000294623(uc001dih.4) ENST00000370768
    ENST00000370767(uc001dii.3 uc010orm.2) ENST00000487684 ENST00000470287
    ENST00000421641 ENST00000436586
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    hsa-miR-579 hsa-miR-607 hsa-miR-429 hsa-miR-15a hsa-miR-548k hsa-miR-199a-3p hsa-miR-1245 hsa-let-7a-2*
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      QuantiTect SYBR Green Assays in human, mouse, rat FUBP1
      QuantiFast Probe-based Assays in human, mouse, rat FUBP1

    Additional mRNA sequence: 

    AB209366.1 AK300032.1 AK301581.1 AK303568.1 BC010083.2 BC017247.2 U05040.2 

    18 DOTS entries:

    DT.100826910  DT.100777780  DT.95252113  DT.100777782  DT.100777778  DT.95320733  DT.121441333  DT.100799717 
    DT.75140914  DT.100715257  DT.40310308  DT.92435450  DT.121441301  DT.40122831  DT.40123716  DT.121441297 
    DT.121441357  DT.91998223 

    Selected AceView cDNA sequences (see all 362):

    CB044319 BQ921398 BX360253 BC017247 AA252456 BQ924415 AA504707 BP358119 
    BC010083 BU620158 AI281811 BQ934904 BI491052 BX360777 CA389287 AI588848 
    F02332 AI285572 CK823182 BU161377 AA251462 AL532525 BG388197 AI138630 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FUBP1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21a ·
    SP1:                                                                          -                 -     -                                         -     -     -   
    SP2:                                                                          -                 -     -                                         -               
    SP3:                                                                          -                 -     -                                                         
    SP4:                                                                                                                                            -     -     -   
    SP5:                                                                                                                                                            

    ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:              -                     
    SP5:                                    


    ECgene alternative splicing isoforms for FUBP1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FUBP1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    FUBP1 Expression
    About this image


    FUBP1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Gonad (Reproductive System)
             Primordial Germ Cells Primitive Gonad
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    FUBP1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FUBP1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567380
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for FUBP1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fubp11 , 5 far upstream element (FUSE) binding protein 11, 5 91.44(n)1
    98.59(a)1
      3 (77.05 cM)5
    518861  NM_057172.31  NP_476513.21 
     1522104585 
    chicken
    (Gallus gallus)
    Aves FUBP11 far upstream element (FUSE) binding protein 1 84.18(n)
    91.97(a)
      424551  NM_001006535.1  NP_001006535.1 
    lizard
    (Anolis carolinensis)
    Reptilia FUBP16
    far upstream element (FUSE) binding protein 1
    83(a)
    1 ↔ 1
    GL343194.1(4801696-4831828)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044277.12   -- 84.74(n)    BC044277.1 
    zebrafish
    (Danio rerio)
    Actinopterygii mpzf637-1-0016112 Danio rerio cDNA clone MGC66046 IMAGE6794933, complete cds less 78.24(n)    BC064649.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Psi6
    P-element somatic inhibitor
    24(a)
    1 → many
    2R(12748826-12755219)
    worm
    (Caenorhabditis elegans)
    Secernentea C12D8.1b3 RNA binding protein 38(a)
    (best of 6)
      V(10238862-10240838)   --


    ENSEMBL Gene Tree for FUBP1 (if available)
    TreeFam Gene Tree for FUBP1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FUBP1 gene
    KHSRP2  FUBP32  
    4 SIMAP similar genes for FUBP1 using alignment to 5 protein entries:     FUBP1_HUMAN (see all proteins):
    KHSRP    NOVA1    FUBP3    PCBP2

    Find genes that share paralogs with FUBP1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FUBP1 (see all 700)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1414368611,2
    C--78413101(+) ATACTC/GTTGCA 1 -- ds50010--------
    rs1163420121,2
    F--78413487(+) TTGAAC/TGTTTC 1 -- ds50011Minor allele frequency- T:0.02WA 118
    rs1897681311,2
    --78413687(+) TATGCC/TGAAAC 1 -- ut310--------
    rs1439423641,2
    --78413694(+) AAACAA/GTCTTG 1 -- ut310--------
    rs1824251381,2
    --78413711(+) AAGTAG/TTATCA 1 -- ut310--------
    rs1870524621,2
    --78413865(+) GGAAAA/GAAAAT 1 -- ut310--------
    rs1512475551,2
    --78413983(+) ACTCAA/GTATTT 1 -- ut310--------
    rs1404609661,2
    --78414054(+) TGAATC/TCTTTA 1 -- ut310--------
    rs716968761,2
    C--78414311(+) TTTTC-/AAAAAAA 1 -- ut310--------
    rs1997696731,2
    C--78414330(-) TGTTTC/TCNNNN 1 -- ut310--------

    HapMap Linkage Disequilibrium report for FUBP1 (78409740 - 78444794 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for FUBP1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518855CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FUBP1
    DNA2.0 Custom Variant and Variant Library Synthesis for FUBP1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603444    OMIM disorders: --

    1 disease for FUBP1:    
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    oligoastrocytoma

    1 disease from the University of Copenhagen DISEASES database for FUBP1:
    Oligodendroglioma

    Find genes that share disorders with FUBP1           About GenesLikeMe


    Export disorders for FUBP1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FUBP1 gene, integrated from 10 sources (see all 84):
    (articles sorted by number of sources associating them with FUBP1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif. (PubMed id 8125259)1, 2, 3, 9 Duncan R.... Levens D. (Genes Dev. 1994)
    2. Identification of human DNA helicase V with the far upstream element- binding protein. (PubMed id 11222755)1, 2, 9 Vindigni A.... Falaschi A. (Nucleic Acids Res. 2001)
    3. Structure and dynamics of KH domains from FBP bound to single- stranded DNA. (PubMed id 11875576)1, 2, 9 Braddock D.T.... Clore G.M. (Nature 2002)
    4. The FBP interacting repressor targets TFIIH to inhibit activated transcription. (PubMed id 10882074)1, 2, 9 Liu J....Levens D. (Mol. Cell 2000)
    5. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Downregulation of FUSE-binding protein and c-myc by tRNA synthetase cofactor p38 is required for lung cell differentiation. (PubMed id 12819782)1, 2 Kim M.J.... Kim S. (Nat. Genet. 2003)
    9. Large-scale proteomic analysis of the human spliceosome. (PubMed id 12176931)1, 2 Rappsilber J.... Mann M. (Genome Res. 2002)
    10. Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. (PubMed id 20420426)1, 9 Hsiao H.H....Braddock D.T. (Biochemistry 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8880 HGNC: 4004 AceView: FUBP1 Ensembl:ENSG00000162613 euGenes: HUgn8880
    ECgene: FUBP1 H-InvDB: FUBP1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FUBP1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FUBP1 gene:
    Search GeneIP for patents involving FUBP1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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