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Aliases for FUBP1 Gene

Aliases for FUBP1 Gene

  • Far Upstream Element (FUSE) Binding Protein 1 2 3
  • DNA Helicase V 3 4
  • HDH V 3 4
  • FBP 3 4
  • FUSE-Binding Protein 1 4
  • FUBP 3

External Ids for FUBP1 Gene

Previous HGNC Symbols for FUBP1 Gene

  • FUBP

Previous GeneCards Identifiers for FUBP1 Gene

  • GC01M078564
  • GC01M077358
  • GC01M077800
  • GC01M077834
  • GC01M078124
  • GC01M078400
  • GC01M076545

Summaries for FUBP1 Gene

Entrez Gene Summary for FUBP1 Gene

  • The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for FUBP1 Gene

FUBP1 (Far Upstream Element (FUSE) Binding Protein 1) is a Protein Coding gene. Diseases associated with FUBP1 include oligodendroglioma and mouth disease. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is KHSRP.

UniProtKB/Swiss-Prot for FUBP1 Gene

  • Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.

Gene Wiki entry for FUBP1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUBP1 Gene

Genomics for FUBP1 Gene

Regulatory Elements for FUBP1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FUBP1 Gene

Chromosome:
1
Start:
77,944,055 bp from pter
End:
77,979,205 bp from pter
Size:
35,151 bases
Orientation:
Minus strand

Genomic View for FUBP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FUBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUBP1 Gene

Proteins for FUBP1 Gene

  • Protein details for FUBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AE4-FUBP1_HUMAN
    Recommended name:
    Far upstream element-binding protein 1
    Protein Accession:
    Q96AE4
    Secondary Accessions:
    • Q12828

    Protein attributes for FUBP1 Gene

    Size:
    644 amino acids
    Molecular mass:
    67560 Da
    Quaternary structure:
    • Found in a complex with PUF60 and far upstream element (FUSE) DNA segment. Interacts with PUF60 and JTV1.

    Three dimensional structures from OCA and Proteopedia for FUBP1 Gene

    Alternative splice isoforms for FUBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUBP1 Gene

Proteomics data for FUBP1 Gene at MOPED

Post-translational modifications for FUBP1 Gene

  • Ubiquitinated. This targets the protein for proteasome-mediated degradation.
  • Ubiquitination at Lys 64
  • Modification sites at PhosphoSitePlus

Other Protein References for FUBP1 Gene

No data available for DME Specific Peptides for FUBP1 Gene

Domains & Families for FUBP1 Gene

Protein Domains for FUBP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96AE4

UniProtKB/Swiss-Prot:

FUBP1_HUMAN :
  • Contains 4 KH domains.
Domain:
  • Contains 4 KH domains.
genes like me logo Genes that share domains with FUBP1: view

No data available for Gene Families for FUBP1 Gene

Function for FUBP1 Gene

Molecular function for FUBP1 Gene

UniProtKB/Swiss-Prot Function:
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.

Gene Ontology (GO) - Molecular Function for FUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0003676 nucleic acid binding --
GO:0003697 single-stranded DNA binding TAS 8125259
GO:0003700 transcription factor activity, sequence-specific DNA binding TAS 8125259
GO:0003723 RNA binding --
genes like me logo Genes that share ontologies with FUBP1: view
genes like me logo Genes that share phenotypes with FUBP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUBP1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for FUBP1 Gene

Localization for FUBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUBP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FUBP1 Gene COMPARTMENTS Subcellular localization image for FUBP1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 19087307
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FUBP1: view

Pathways & Interactions for FUBP1 Gene

SuperPathways for FUBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0010628 positive regulation of gene expression IDA 19087307
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with FUBP1: view

No data available for Pathways by source and SIGNOR curated interactions for FUBP1 Gene

Drugs & Compounds for FUBP1 Gene

(2) Drugs for FUBP1 Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MGI-114 Investigational Pharma Target 0
ATP Pharma Activator 0
genes like me logo Genes that share compounds with FUBP1: view

Transcripts for FUBP1 Gene

Unigene Clusters for FUBP1 Gene

Far upstream element (FUSE) binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FUBP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21a ·
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for FUBP1 Gene

GeneLoc Exon Structure for
FUBP1
ECgene alternative splicing isoforms for
FUBP1

Expression for FUBP1 Gene

mRNA expression in normal human tissues for FUBP1 Gene

Protein differential expression in normal tissues from HIPED for FUBP1 Gene

This gene is overexpressed in Lymph node (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FUBP1 Gene



SOURCE GeneReport for Unigene cluster for FUBP1 Gene Hs.567380

genes like me logo Genes that share expression patterns with FUBP1: view

Protein tissue co-expression partners for FUBP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FUBP1 Gene

Orthologs for FUBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUBP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FUBP1 35
  • 95.23 (n)
  • 99.69 (a)
FUBP1 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FUBP1 35
  • 95.22 (n)
  • 99.84 (a)
FUBP1 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fubp1 35
  • 91.44 (n)
  • 98.59 (a)
Fubp1 16
Fubp1 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fubp1 35
  • 91.65 (n)
  • 99.37 (a)
oppossum
(Monodelphis domestica)
Mammalia FUBP1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUBP1 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FUBP1 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUBP1 35
  • 84.18 (n)
  • 91.97 (a)
FUBP1 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FUBP1 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fubp1 35
  • 80.22 (n)
  • 90.19 (a)
MGC75632 35
zebrafish
(Danio rerio)
Actinopterygii fubp1 35
  • 72.86 (n)
  • 81.18 (a)
mpzf637-1-001611 35
fubp1 36
  • 71 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Psi 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C12D8.1a 37
  • 37 (a)
C12D8.1b 37
  • 38 (a)
C36E6.1a 37
  • 32 (a)
C36E6.1b 37
  • 32 (a)
M01A10.1 37
  • 32 (a)
ZK418.9 37
  • 32 (a)
C12D8.1 36
  • 28 (a)
ManyToMany
C36E6.1 36
  • 24 (a)
ManyToMany
M01A10.1 36
  • 22 (a)
ManyToMany
ZK418.9 36
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 21 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
-- 36
  • 35 (a)
ManyToMany
Species with no ortholog for FUBP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUBP1 Gene

ENSEMBL:
Gene Tree for FUBP1 (if available)
TreeFam:
Gene Tree for FUBP1 (if available)

Paralogs for FUBP1 Gene

Paralogs for FUBP1 Gene

(4) SIMAP similar genes for FUBP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FUBP1: view

Variants for FUBP1 Gene

Sequence variations from dbSNP and Humsavar for FUBP1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs750720 -- 77,956,100(-) GATTT(C/T)TGATT intron-variant
rs1002553 -- 77,954,465(+) TTGTG(C/T)AAAAC intron-variant
rs1007335 -- 77,956,423(-) GAAAT(A/G)GTTTC intron-variant
rs1536160 -- 77,967,263(-) AACTA(C/T)TCAAG intron-variant
rs1555798 -- 77,959,504(-) CCAAC(A/G)GAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FUBP1 Gene

Variant ID Type Subtype PubMed ID
nsv518855 CNV Loss 19592680

Variation tolerance for FUBP1 Gene

Residual Variation Intolerance Score: 9.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FUBP1 Gene

HapMap Linkage Disequilibrium report
FUBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUBP1 Gene

Disorders for FUBP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FUBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oligodendroglioma
  • oligodendroglial tumor
mouth disease
  • mouth disorders
- elite association
Search FUBP1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for FUBP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FUBP1
genes like me logo Genes that share disorders with FUBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUBP1 Gene

Publications for FUBP1 Gene

  1. A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif. (PMID: 8125259) Duncan R. … Levens D. (Genes Dev. 1994) 2 23 67
  2. Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. (PMID: 20420426) Hsiao H.H. … Braddock D.T. (Biochemistry 2010) 23 67
  3. The functional response of upstream DNA to dynamic supercoiling in vivo. (PMID: 18193062) Kouzine F. … Levens D. (Nat. Struct. Mol. Biol. 2008) 23 67
  4. Hierarchical mechanisms build the DNA-binding specificity of FUSE binding protein. (PMID: 19015535) Benjamin L.R. … Levens D. (Proc. Natl. Acad. Sci. U.S.A. 2008) 23 67
  5. Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition. (PMID: 18059478) Crichlow G.V. … Braddock D. (EMBO J. 2008) 23 67

Products for FUBP1 Gene

Sources for FUBP1 Gene

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