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Aliases for FUBP1 Gene

Aliases for FUBP1 Gene

  • Far Upstream Element Binding Protein 1 2 3 5
  • Far Upstream Element (FUSE) Binding Protein 1 2 3
  • FUSE Binding Protein 1 2 3
  • DNA Helicase V 3 4
  • HDH V 3 4
  • FBP 3 4
  • Far Upstream Element-Binding Protein 1 3
  • FUSE-Binding Protein 1 4
  • FUBP 3

External Ids for FUBP1 Gene

Previous HGNC Symbols for FUBP1 Gene

  • FUBP

Previous GeneCards Identifiers for FUBP1 Gene

  • GC01M078564
  • GC01M077358
  • GC01M077800
  • GC01M077834
  • GC01M078124
  • GC01M078400
  • GC01M076545

Summaries for FUBP1 Gene

Entrez Gene Summary for FUBP1 Gene

  • The protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located upstream of c-myc. Binding to FUSE occurs on the non-coding strand, and is important to the regulation of c-myc in undifferentiated cells. This protein contains three domains, an amphipathic helix N-terminal domain, a DNA-binding central domain, and a C-terminal transactivation domain that contains three tyrosine-rich motifs. The N-terminal domain is thought to repress the activity of the C-terminal domain. This protein is also thought to bind RNA, and contains 3'-5' helicase activity with in vitro activity on both DNA-DNA and RNA-RNA duplexes. Aberrant expression of this gene has been found in malignant tissues, and this gene is important to neural system and lung development. Binding of this protein to viral RNA is thought to play a role in several viral diseases, including hepatitis C and hand, foot and mouth disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for FUBP1 Gene

FUBP1 (Far Upstream Element Binding Protein 1) is a Protein Coding gene. Diseases associated with FUBP1 include Oligodendroglioma and Mouth Disease. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is KHSRP.

UniProtKB/Swiss-Prot for FUBP1 Gene

  • Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.

Gene Wiki entry for FUBP1 Gene

Additional gene information for FUBP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FUBP1 Gene

Genomics for FUBP1 Gene

GeneHancer (GH) Regulatory Elements for FUBP1 Gene

Promoters and enhancers for FUBP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I077975 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.9 923 5.5 CLOCK FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF143 SP3 SSRP1 ZNF610 GIPC2 FUBP1 DNAJB4 NSRP1P1 ENSG00000273338 USP33 ZZZ3 NEXN NEXN-AS1
GH01I077680 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 48.2 +296.3 296308 4 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZZZ3 FUBP1 RPL17P6 ENSG00000273338 NEXN GIPC2 AK5 DNAJB4 RN7SL370P
GH01I078619 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 37.6 -641.7 -641747 3.8 PKNOX1 SMAD1 NFIB ZNF529 ZNF195 ZNF366 ZNF350 ETV6 BCLAF1 IKZF2 IFI44L ZZZ3 ENSG00000273338 NSRP1P1 FUBP1 USP33 IFI44
GH01I078002 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.1 -27.7 -27724 8.6 HDGF HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 ZNF2 DNAJB4 NSRP1P1 FUBP1 ENSG00000273338 USP33 ZZZ3 GIPC2 NEXN LOC100131495
GH01I077886 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 6.2 +89.8 89805 5 HDGF SIN3A DMAP1 ZNF2 ZNF121 GLIS2 FOS KLF13 YY2 REST NEXN-AS1 NEXN USP33 GIPC2 FUBP1 IFI44
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FUBP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FUBP1 gene promoter:

Genomic Locations for FUBP1 Gene

Genomic Locations for FUBP1 Gene
chr1:77,944,055-77,979,205
(GRCh38/hg38)
Size:
35,151 bases
Orientation:
Minus strand
chr1:78,409,740-78,444,794
(GRCh37/hg19)

Genomic View for FUBP1 Gene

Genes around FUBP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FUBP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FUBP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FUBP1 Gene

Proteins for FUBP1 Gene

  • Protein details for FUBP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AE4-FUBP1_HUMAN
    Recommended name:
    Far upstream element-binding protein 1
    Protein Accession:
    Q96AE4
    Secondary Accessions:
    • Q12828

    Protein attributes for FUBP1 Gene

    Size:
    644 amino acids
    Molecular mass:
    67560 Da
    Quaternary structure:
    • Found in a complex with PUF60 and far upstream element (FUSE) DNA segment. Interacts with PUF60 and JTV1.

    Three dimensional structures from OCA and Proteopedia for FUBP1 Gene

    Alternative splice isoforms for FUBP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FUBP1 Gene

Post-translational modifications for FUBP1 Gene

  • Ubiquitinated. This targets the protein for proteasome-mediated degradation.
  • Ubiquitination at posLast=6464

No data available for DME Specific Peptides for FUBP1 Gene

Domains & Families for FUBP1 Gene

Gene Families for FUBP1 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FUBP1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FUBP1: view

No data available for UniProtKB/Swiss-Prot for FUBP1 Gene

Function for FUBP1 Gene

Molecular function for FUBP1 Gene

UniProtKB/Swiss-Prot Function:
Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription.

Phenotypes From GWAS Catalog for FUBP1 Gene

Gene Ontology (GO) - Molecular Function for FUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003697 single-stranded DNA binding TAS 8125259
GO:0003700 DNA binding transcription factor activity TAS 8125259
GO:0003723 RNA binding IEA,HDA 22658674
GO:0005515 protein binding IPI 21285945
genes like me logo Genes that share ontologies with FUBP1: view
genes like me logo Genes that share phenotypes with FUBP1: view

Animal Models for FUBP1 Gene

MGI Knock Outs for FUBP1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FUBP1 Gene

Localization for FUBP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FUBP1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FUBP1 gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 19087307
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FUBP1: view

Pathways & Interactions for FUBP1 Gene

SuperPathways for FUBP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FUBP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II TAS 8125259
GO:0010628 positive regulation of gene expression IDA 19087307
genes like me logo Genes that share ontologies with FUBP1: view

No data available for Pathways by source and SIGNOR curated interactions for FUBP1 Gene

Drugs & Compounds for FUBP1 Gene

(2) Drugs for FUBP1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irofulven Investigational Pharma Target 19
genes like me logo Genes that share compounds with FUBP1: view

Transcripts for FUBP1 Gene

Unigene Clusters for FUBP1 Gene

Far upstream element (FUSE) binding protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FUBP1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b · 19c ^ 20 ^ 21a ·
SP1: - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5:
SP6:
SP7:

ExUns: 21b ^ 22a · 22b ^ 23 ^ 24a · 24b
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for FUBP1 Gene

GeneLoc Exon Structure for
FUBP1
ECgene alternative splicing isoforms for
FUBP1

Expression for FUBP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FUBP1 Gene

Protein differential expression in normal tissues from HIPED for FUBP1 Gene

This gene is overexpressed in Lymph node (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FUBP1 Gene



Protein tissue co-expression partners for FUBP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FUBP1 Gene:

FUBP1

SOURCE GeneReport for Unigene cluster for FUBP1 Gene:

Hs.567380

Evidence on tissue expression from TISSUES for FUBP1 Gene

  • Nervous system(4.6)
  • Intestine(2.4)
  • Spleen(2)
genes like me logo Genes that share expression patterns with FUBP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FUBP1 Gene

Orthologs for FUBP1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FUBP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FUBP1 34
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FUBP1 33 34
  • 95.23 (n)
dog
(Canis familiaris)
Mammalia FUBP1 33 34
  • 95.22 (n)
rat
(Rattus norvegicus)
Mammalia Fubp1 33
  • 91.65 (n)
mouse
(Mus musculus)
Mammalia Fubp1 33 16 34
  • 91.44 (n)
oppossum
(Monodelphis domestica)
Mammalia FUBP1 34
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FUBP1 34
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves FUBP1 33 34
  • 84.18 (n)
lizard
(Anolis carolinensis)
Reptilia FUBP1 34
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fubp1 33
  • 80.22 (n)
MGC75632 33
zebrafish
(Danio rerio)
Actinopterygii fubp1 33 34
  • 72.86 (n)
mpzf637-1-001611 33
fruit fly
(Drosophila melanogaster)
Insecta Psi 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C12D8.1b 35
  • 38 (a)
C12D8.1a 35
  • 37 (a)
C36E6.1a 35
  • 32 (a)
C36E6.1b 35
  • 32 (a)
M01A10.1 35 34
  • 32 (a)
ZK418.9 35 34
  • 32 (a)
C12D8.1 34
  • 28 (a)
ManyToMany
C36E6.1 34
  • 24 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
ManyToMany
-- 34
  • 33 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
Species where no ortholog for FUBP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FUBP1 Gene

ENSEMBL:
Gene Tree for FUBP1 (if available)
TreeFam:
Gene Tree for FUBP1 (if available)

Paralogs for FUBP1 Gene

Paralogs for FUBP1 Gene

(4) SIMAP similar genes for FUBP1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with FUBP1: view

Variants for FUBP1 Gene

Sequence variations from dbSNP and Humsavar for FUBP1 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs150511446 uncertain-significance, Dilated Cardiomyopathy, Dominant, Hypertrophic cardiomyopathy 77,943,849(-) T/A downstream_transcript_variant
rs192101966 uncertain-significance, Dilated Cardiomyopathy, Dominant, Hypertrophic cardiomyopathy 77,943,588(-) T/A downstream_transcript_variant
rs569415834 uncertain-significance, Dilated Cardiomyopathy, Dominant, Hypertrophic cardiomyopathy 77,943,638(-) T/C/G downstream_transcript_variant
rs869025239 uncertain-significance, Ductal breast carcinoma 77,956,666(-) C/T coding_sequence_variant, non_coding_transcript_variant, stop_gained
rs886046543 uncertain-significance, Dilated Cardiomyopathy, Dominant, Hypertrophic cardiomyopathy 77,943,728(-) G/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FUBP1 Gene

Variant ID Type Subtype PubMed ID
nsv518855 CNV loss 19592680

Variation tolerance for FUBP1 Gene

Residual Variation Intolerance Score: 9.86% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.82% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FUBP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FUBP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FUBP1 Gene

Disorders for FUBP1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for FUBP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
oligodendroglioma
  • oligodendroglial neoplasm
mouth disease
  • abnormality of the mouth
- elite association - COSMIC cancer census association via MalaCards
Search FUBP1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FUBP1

genes like me logo Genes that share disorders with FUBP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FUBP1 Gene

Publications for FUBP1 Gene

  1. A sequence-specific, single-strand binding protein activates the far upstream element of c-myc and defines a new DNA-binding motif. (PMID: 8125259) Duncan R … Levens D (Genes & development 1994) 2 3 4 22 58
  2. Structure and dynamics of KH domains from FBP bound to single-stranded DNA. (PMID: 11875576) Braddock DT … Clore GM (Nature 2002) 3 4 22 58
  3. Identification of human DNA helicase V with the far upstream element-binding protein. (PMID: 11222755) Vindigni A … Falaschi A (Nucleic acids research 2001) 3 4 22 58
  4. The FBP interacting repressor targets TFIIH to inhibit activated transcription. (PMID: 10882074) Liu J … Levens D (Molecular cell 2000) 3 4 22 58
  5. Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. (PMID: 20420426) Hsiao HH … Braddock DT (Biochemistry 2010) 3 22 58

Products for FUBP1 Gene

Sources for FUBP1 Gene

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