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Aliases for FTX Gene

Subcategory (RNA class) for FTX Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for FTX Gene

  • FTX Transcript, XIST Regulator (Non-Protein Coding) 2 3 5
  • Mir-374a-545 Cluster Host Gene (Non-Protein Coding) 2 3
  • Five Prime To XIST 2 3
  • Non-Protein Coding RNA 182 2
  • NCRNA00182 3
  • LINC00182 3
  • MIR374AHG 3

External Ids for FTX Gene

Previous HGNC Symbols for FTX Gene

  • NCRNA00182
  • MIR374AHG

Previous GeneCards Identifiers for FTX Gene

  • GC0XU990359
  • GC0XM073248
  • GC0XM073183
  • GC0XM073963

Summaries for FTX Gene

Entrez Gene Summary for FTX Gene

  • This gene is located upstream of XIST, within the X-inactivation center (XIC). It produces a spliced long non-coding RNA that is thought to positively regulate the expression of XIST, which is essential for the initiation and spread of X-inactivation. [provided by RefSeq, May 2015]

GeneCards Summary for FTX Gene

FTX (FTX Transcript, XIST Regulator (Non-Protein Coding)) is an RNA Gene, and is affiliated with the non-coding RNA class.

Additional gene information for FTX Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTX Gene

Genomics for FTX Gene

Regulatory Elements for FTX Gene

Enhancers for FTX Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XH073943 1.2 ENCODE 86.4 +349.0 349035 2 MLX FEZF1 DMAP1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZC3H11A FTX ENSG00000271199 RAB11FIP1P1 JPX DDX3P1 RN7SL648P CHIC1 ENSG00000228906 TOMM20P4 ENSG00000271533
GH0XH073850 1.1 ENCODE 34 +441.9 441900 2 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF302 ZNF143 ZNF548 RAB11FIP1P1 JPX ENSG00000271199 RN7SL648P FTX DDX3P1 ENSG00000234969 ENSG00000271533 MKRN5P TOMM20P4
GH0XH074342 1.2 Ensembl ENCODE 13.2 -50.1 -50057 1 FEZF1 ZNF2 ETS1 ZNF766 ZNF143 FOS KLF7 RUNX3 DEK TSHZ1 FTX ZCCHC13 ENSG00000271533 ENSG00000226515 LOC727681
GH0XH074248 1.1 Ensembl ENCODE 12.9 +43.0 42972 4 HDAC1 ELF3 FOXA2 FEZF1 ZBTB40 TCF12 ZNF121 ZSCAN5C FOS ZEB2 MIR374B MIR421 MIR374A MIR545 FTX JPX GC0XP074249 ENSG00000278421
GH0XH074240 1.1 Ensembl ENCODE 12.7 +51.1 51148 2 ELF3 FOXA2 THRB RARA CREM MIXL1 PPARG NFIL3 CEBPA ETV4 MIR421 MIR374B FTX ZCCHC13 MIR545 MIR374A JPX RN7SL648P GC0XP074233
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FTX on UCSC Golden Path with GeneCards custom track

Promoters for FTX Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000247264 1874 4600 HDGF PKNOX1 ATF1 ARNT BRCA1 YY1 GTF3C2 GLIS2 KLF7 ATF7

Genomic Location for FTX Gene

Chromosome:
X
Start:
73,946,555 bp from pter
End:
74,293,574 bp from pter
Size:
347,020 bases
Orientation:
Minus strand

Genomic View for FTX Gene

Genes around FTX on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTX Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTX Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTX Gene

Proteins for FTX Gene

Post-translational modifications for FTX Gene

No Post-translational modifications

No data available for DME Specific Peptides for FTX Gene

Domains & Families for FTX Gene

Gene Families for FTX Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FTX: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FTX Gene

Function for FTX Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for FTX
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTX Gene

Localization for FTX Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FTX Gene

Pathways & Interactions for FTX Gene

No Data Available

Interacting Proteins for FTX Gene

Gene Ontology (GO) - Biological Process for FTX Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FTX Gene

Drugs & Compounds for FTX Gene

No Compound Related Data Available

Transcripts for FTX Gene

mRNA/cDNA for FTX Gene

(4) Additional mRNA sequences :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FTX Gene

FTX transcript, XIST regulator (non-protein coding):
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for FTX
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for FTX Gene

No ASD Table

Relevant External Links for FTX Gene

GeneLoc Exon Structure for
FTX
ECgene alternative splicing isoforms for
FTX

Expression for FTX Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FTX Gene

NURSA nuclear receptor signaling pathways regulating expression of FTX Gene:

FTX

SOURCE GeneReport for Unigene cluster for FTX Gene:

Hs.349570
genes like me logo Genes that share expression patterns with FTX: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTX Gene

Orthologs for FTX Gene

Evolution for FTX Gene

ENSEMBL:
Gene Tree for FTX (if available)
TreeFam:
Gene Tree for FTX (if available)

No data available for Orthologs for FTX Gene

Paralogs for FTX Gene

No data available for Paralogs for FTX Gene

Variants for FTX Gene

Sequence variations from dbSNP and Humsavar for FTX Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1000002777 -- 74,219,524(+) GCCCC(C/T)TGAAA intron-variant, upstream-variant-2KB
rs1000033517 -- 74,218,756(+) TATAG(A/G)GTGCC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1000052061 -- 74,226,897(+) CTCAG(C/T)ATGCT intron-variant
rs1000057337 -- 74,091,321(+) CCTGC(C/T)TTAGC intron-variant
rs1000063390 -- 74,142,763(+) CCTTA(A/C/T)ACAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FTX Gene

Variant ID Type Subtype PubMed ID
esv2740225 CNV deletion 23290073
esv2740226 CNV deletion 23290073
esv2740227 CNV deletion 23290073

Relevant External Links for FTX Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FTX

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FTX Gene

Disorders for FTX Gene

Relevant External Links for FTX

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FTX

No disorders were found for FTX Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTX Gene

Publications for FTX Gene

  1. Ftx is a non-coding RNA which affects Xist expression and chromatin structure within the X-inactivation center region. (PMID: 21118898) Chureau C … Rougeulle C (Human molecular genetics 2011) 2 3 60
  2. [Comparative organization and the origin of noncoding regulatory RNA genes from X-chromosome inactivation center of human and mouse]. (PMID: 21254562) Kolesnikov NN … Elisafenko EA (Genetika 2010) 2 3 60
  3. Comparative sequence analysis of the X-inactivation center region in mouse, human, and bovine. (PMID: 12045143) Chureau C … Duret L (Genome research 2002) 2 3 60
  4. Long noncoding RNA FTX inhibits hepatocellular carcinoma proliferation and metastasis by binding MCM2 and miR-374a. (PMID: 27065331) Liu F … Sun SH (Oncogene 2016) 3 60
  5. The miR-545/374a cluster encoded in the Ftx lncRNA is overexpressed in HBV-related hepatocellular carcinoma and promotes tumorigenesis and tumor progression. (PMID: 25299640) Zhao Q … Qin C (PloS one 2014) 3 60

Products for FTX Gene

Sources for FTX Gene

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