FTSJD1 Gene
protein-coding GIFtS: 44
GCID: GC16M071316
|
|
FtsJ methyltransferase domain containing 1
| |
Aliases
for FTSJD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| FtsJ Methyltransferase Domain Containing 11 2 | | Adrift Homolog2 | | AFT1 2 3 | | FtsJ Methyltransferase Domain-Containing Protein 12 | | MTr21 2 | | EC 2.1.1.-3 | | Protein Adrift Homolog2 3 | | EC 2.1.18 | | FLJ111711 | | |
Export aliases for FTSJD1 gene to outside databasesPrevious GC identifers: GC16M069874 GC16M057079 |
Summaries
for FTSJD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for FTSJD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FTSJD1 gene promoter:
NF-1 SRY Pbx1a p300 MRF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FTSJD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FTSJD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q22.2 Ensembl cytogenetic band: 16q22.2 HGNC cytogenetic band: 16q22.2FTSJD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M071316: view genomic region
(about GC identifiers)
Start:
|
71,315,292 bp from pter |
End:
|
71,323,618 bp from pter |
Size:
|
8,327 bases |
Orientation:
|
minus strand |
|
Proteins
for FTSJD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FTSJ1_HUMAN, Q8IYT2 (See
protein sequence)Recommended Name: FtsJ methyltransferase domain-containing protein 1 Size: 770 amino acids; 88120 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=AAM49718.1; Type=Frameshift; Positions=337; Sequence=BAA91058.1; Type=Frameshift;Positions=739; Sequence=BAB14452.1; Type=Erroneous initiation;
Secondary accessions: B2RCD5 D3DWS1 Q8NE77 Q8NFR5 Q9H8Z4 Q9NUS3 Q9NXF5Explore the universe of human proteins at neXtProt for FTSJD1: NX_Q8IYT2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IYT2
4 DME Specific Peptides for FTSJD1 (Q8IYT2)
FTSJD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001093112.1 NP_060818.4
ENSEMBL proteins: ENSP00000337512 ENSP00000411148 ENSP00000457399 ENSP00000456036 ENSP00000456476 ENSP00000455080 ENSP00000457679
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
FTSJD1 for ontologies About GeneDecksing
FTSJD1 Antibody Products:
Assay Products for FTSJD1: |
Protein
Domains /
Families
for FTSJD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FTSJD1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IYT2ProtoNet protein and cluster: Q8IYT2 1 Blocks protein family: IPB002877 Cell division protein FtsJ
UniProtKB/Swiss-Prot: FTSJ1_HUMAN, Q8IYT2Similarity: Belongs to the methyltransferase superfamily. RlmE family. Adrift subfamily |
Function
for FTSJD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Numbers (IUBMB): EC 2.1.1.-1 EC 2.1.12
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTSJD1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTSJD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): FTSJD1 (NM_018348) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FTSJD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FTSJD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTSJD1 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003676 | nucleic acid binding |
-- | -- | | GO:0008168 | methyltransferase activity |
IEA | -- |
FTSJD1 for ontologies About GeneDecksing
|
Pathways & Interactions
for FTSJD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FTSJD1
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FTSJD1 (ENSP000003375124) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for FTSJD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FTSJD1
Search CenterWatch for drugs/clinical trials and news about FTSJD1 / FTSJ1
|
Transcripts
for FTSJD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FTSJD1 gene (2 alternative transcripts): NM_001099642.1 NM_018348.5 Unigene Cluster for FTSJD1: FtsJ methyltransferase domain containing 1 Hs.72782 [show with all ESTs]Unigene Representative Sequence: NM_0183488 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338099(uc002ezz.4) ENST00000434935(uc010cga.3 uc002ezy.4)
ENST00000563876 ENST00000564183 ENST00000565850 ENST00000567610 ENST00000568910
ENST00000564690
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTSJD1 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTSJD1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): FTSJD1 (NM_018348) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FTSJD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FTSJD1 |
Additional cDNA sequence: AF458590.1 AK000289.1 AK002033.1 AK023183.1 AK123343.1 AK226169.1 AK315056.1 BC034468.1 BC035005.2 BX648660.1 12 DOTS entries: DT.86857161 DT.445540 DT.70102873 DT.100751502 DT.120676749 DT.120676755 DT.120676747 DT.100692762 DT.120676750 DT.91725745 DT.40316525 DT.91725746 24/98 AceView cDNA sequences (see all 98): AA630387 AW079291 BQ632350 AI185702 BM724515 BM745619 BC034468 BQ942396 BG720202 AA044588 BC035005 NM_018348 BQ632644 AA282527 AU119050 BQ575586 AW137210 AA196702 BM461820 BF434869 AA282635 AK123343 BF445787 BP336715
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for FTSJD1 (see all 9) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for FTSJD1
|
Expression
for FTSJD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FTSJD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAGTCA
About this image
See FTSJD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FTSJD1
SOURCE GeneReport for Unigene cluster: Hs.72782
SABiosciences Custom PCR Arrays for FTSJD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FTSJD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FTSJD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FTSJD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FTSJD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTSJD1 |
Orthologs
for FTSJD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for FTSJD1 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
FTSJD11 |
FtsJ methyltransferase domain containing 1 |
71.32(n)
67.85(a) |
|
427537 XM_425111.1 XP_425111.1 |
lizard
(Anolis carolinensis) |
Reptilia |
FTSJD16 |
-- |
66(a) |
1 ↔ 1 |
3(196174457-196177037) |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.115742 |
Danio rerio mRNA similar to hypothetical protein FLJ11171 more |
73.53(n) |
|
BC045425.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
aft6 |
adrift |
31(a) |
1 ↔ 1 |
2R(13673642-13676072) |
worm
(Caenorhabditis elegans) |
Secernentea |
Y40D12A.16 |
Protein Y40D12A.1, isoform a |
21(a) |
1 ↔ 1 |
III(6615361-6619996) |
ENSEMBL Gene Tree for FTSJD1 (if available)
TreeFam Gene Tree for FTSJD1 (if available) |
Paralogs
for FTSJD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FTSJD1 gene
- FTSJD22
FTSJD1 for paralogs About GeneDecksing
|
Genomic Variants
for FTSJD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FTSJD1 (71315292 - 71323618 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FTSJD1
1 CNV: 4010 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FTSJD1 |
|
Disorders
/ Diseases
for FTSJD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FTSJD1 for disorders About GeneDecksing
1  disease for FTSJD1: About MalaCardsmotion sickness
Export disorders for FTSJD1 gene to outside databases
|
Publications
for FTSJD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FTSJD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FTSJD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- 2'-O-ribose methylation of cap2 in human: function an d evolution in a horizontally mobile family. (PubMed id 21310715)1, 3 Werner M....Bujnicki J.M. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for FTSJD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FTSJD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FTSJD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FTSJD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FTSJD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FTSJD1 gene:
Search GeneIP for patents involving FTSJD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FTSJD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FTSJD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FTSJD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FTSJD1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FTSJD1 | | OriGene 3'-UTR Clone for FTSJD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTSJD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTSJD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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