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Aliases for FTSJ3 Gene

Aliases for FTSJ3 Gene

  • FtsJ Homolog 3 (E. Coli) 2 3
  • 2-O-Ribose RNA Methyltransferase SPB1 Homolog 3 4
  • Putative RRNA Methyltransferase 3 3 4
  • Protein FtsJ Homolog 3 3 4
  • SPB1 RNA Methyltransferase Homolog (S. Cerevisiae) 2
  • RRNA (Uridine-2-O-)-Methyltransferase 3 3
  • SPB1 RNA Methyltransferase Homolog 3
  • Pre-RRNA Processing Protein FTSJ3 3
  • EC 2.1.1.- 4
  • EPCS3 3
  • SPB1 3

External Ids for FTSJ3 Gene

Previous GeneCards Identifiers for FTSJ3 Gene

  • GC17M061547
  • GC17M064323
  • GC17M062237
  • GC17M062370
  • GC17M059250
  • GC17M061896
  • GC17M057264

Summaries for FTSJ3 Gene

Entrez Gene Summary for FTSJ3 Gene

  • Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FTSJ3 Gene

FTSJ3 (FtsJ Homolog 3 (E. Coli)) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot for FTSJ3 Gene

  • Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.

Gene Wiki entry for FTSJ3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTSJ3 Gene

Genomics for FTSJ3 Gene

Regulatory Elements for FTSJ3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FTSJ3 Gene

Start:
63,819,433 bp from pter
End:
63,830,012 bp from pter
Size:
10,580 bases
Orientation:
Minus strand

Genomic View for FTSJ3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FTSJ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTSJ3 Gene

Proteins for FTSJ3 Gene

  • Protein details for FTSJ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY81-SPB1_HUMAN
    Recommended name:
    pre-rRNA processing protein FTSJ3
    Protein Accession:
    Q8IY81
    Secondary Accessions:
    • B2RCA5
    • D3DU22
    • Q8N3A3
    • Q8WXX1
    • Q9BWM4
    • Q9NXT6

    Protein attributes for FTSJ3 Gene

    Size:
    847 amino acids
    Molecular mass:
    96558 Da
    Quaternary structure:
    • Interacts with NIP7.
    SequenceCaution:
    • Sequence=BAA90924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FTSJ3 Gene

Proteomics data for FTSJ3 Gene at MOPED

Post-translational modifications for FTSJ3 Gene

No data available for DME Specific Peptides for FTSJ3 Gene

Domains for FTSJ3 Gene

Suggested Antigen Peptide Sequences for FTSJ3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY81

UniProtKB/Swiss-Prot:

SPB1_HUMAN :
  • Q8IY81
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
genes like me logo Genes that share domains with FTSJ3: view

No data available for Gene Families for FTSJ3 Gene

Function for FTSJ3 Gene

Molecular function for FTSJ3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2-O-methylnucleoside.
UniProtKB/Swiss-Prot Function:
Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.

Enzyme Numbers (IUBMB) for FTSJ3 Gene

Gene Ontology (GO) - Molecular Function for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
GO:0008168 methyltransferase activity --
GO:0008649 rRNA methyltransferase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with FTSJ3: view

Animal Model Products

miRNA for FTSJ3 Gene

miRTarBase miRNAs that target FTSJ3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FTSJ3

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for FTSJ3 Gene

Localization for FTSJ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FTSJ3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FTSJ3 Gene COMPARTMENTS Subcellular localization image for FTSJ3 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0030688 preribosome, small subunit precursor IEA --
genes like me logo Genes that share ontologies with FTSJ3: view

Pathways for FTSJ3 Gene

SuperPathways for FTSJ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000453 enzyme-directed rRNA 2-O-methylation IEA --
GO:0006364 rRNA processing --
GO:0031167 rRNA methylation --
GO:0032259 methylation --
genes like me logo Genes that share ontologies with FTSJ3: view

No data available for Pathways by source for FTSJ3 Gene

Compounds for FTSJ3 Gene

(1) HMDB Compounds for FTSJ3 Gene

Compound Synonyms Cas Number PubMed IDs
S-Adenosylmethionine
  • (3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine
29908-03-0
genes like me logo Genes that share compounds with FTSJ3: view

Transcripts for FTSJ3 Gene

mRNA/cDNA for FTSJ3 Gene

(11) Selected AceView cDNA sequences:
(10) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FTSJ3 Gene

FtsJ homolog 3 (E. coli):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FTSJ3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTSJ3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - -
SP6:
SP7:
SP8: -
SP9: - -
SP10:
SP11: - -
SP12:
SP13:

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FTSJ3 Gene

GeneLoc Exon Structure for
FTSJ3
ECgene alternative splicing isoforms for
FTSJ3

Expression for FTSJ3 Gene

mRNA expression in normal human tissues for FTSJ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for FTSJ3 Gene

This gene is overexpressed in Lung (16.4), Peripheral blood mononuclear cells (12.1), and Adrenal (11.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for FTSJ3 Gene

SOURCE GeneReport for Unigene cluster for FTSJ3 Gene Hs.463785

genes like me logo Genes that share expressions with FTSJ3: view

Expression partners for FTSJ3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FTSJ3 Gene

Orthologs for FTSJ3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FTSJ3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FTSJ3 35
  • 87.36 (n)
  • 89.27 (a)
FTSJ3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FTSJ3 35
  • 86.52 (n)
  • 89.05 (a)
FTSJ3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ftsj3 35
  • 85.25 (n)
  • 88.12 (a)
Ftsj3 16
Ftsj3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FTSJ3 35
  • 99.37 (n)
  • 99.17 (a)
FTSJ3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ftsj3 35
  • 84.41 (n)
  • 87.03 (a)
oppossum
(Monodelphis domestica)
Mammalia FTSJ3 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJ3 35
  • 69.53 (n)
  • 70.51 (a)
FTSJ3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FTSJ3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsj3 35
  • 70.98 (n)
  • 76.62 (a)
Str.15904 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3413 35
zebrafish
(Danio rerio)
Actinopterygii ftsj 35
  • 63.82 (n)
  • 63.61 (a)
wufa11d10 35
ftsj 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.481 35
fruit fly
(Drosophila melanogaster)
Insecta CG8939 37
  • 38 (a)
CG8939 35
  • 51.96 (n)
  • 44.78 (a)
CG8939 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003002 35
  • 52.51 (n)
  • 45.21 (a)
worm
(Caenorhabditis elegans)
Secernentea H06I04.3a 37
  • 55 (a)
H06I04.3b 37
  • 55 (a)
H06I04.3 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPB1 36
  • 36 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.20336 35
corn
(Zea mays)
Liliopsida Zm.14347 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9297 36
  • 47 (a)
OneToOne
Species with no ortholog for FTSJ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FTSJ3 Gene

ENSEMBL:
Gene Tree for FTSJ3 (if available)
TreeFam:
Gene Tree for FTSJ3 (if available)

Paralogs for FTSJ3 Gene

Selected SIMAP similar genes for FTSJ3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FTSJ3: view

No data available for Paralogs for FTSJ3 Gene

Variants for FTSJ3 Gene

Sequence variations from dbSNP and Humsavar for FTSJ3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs752621 -- 63,824,520(+) CAAAA(C/G)GCTCA intron-variant
rs894406 -- 63,824,297(-) TGGAC(C/T)GGGTG intron-variant
rs894407 -- 63,824,281(-) GGGAA(A/G)AGTCT intron-variant
rs2584627 -- 63,824,079(-) GGTGA(A/G)AGGAG intron-variant
rs2665836 -- 63,820,775(-) TTTTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FTSJ3 Gene

Variant ID Type Subtype PubMed ID
nsv833510 CNV Loss 17160897
nsv510720 CNV Loss 20534489
nsv517272 CNV Gain+Loss 19592680

Relevant External Links for FTSJ3 Gene

HapMap Linkage Disequilibrium report
FTSJ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FTSJ3 Gene

Disorders for FTSJ3 Gene

No disorders were found for FTSJ3 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for FTSJ3 Gene

Publications for FTSJ3 Gene

  1. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. (PMID: 22195017) Morello L.G. … Zanchin N.I. (PLoS ONE 2011) 3 4
  2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for FTSJ3 Gene

Sources for FTSJ3 Gene

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