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Aliases for FTSJ3 Gene

Aliases for FTSJ3 Gene

  • FtsJ Homolog 3 (E. Coli) 2 3
  • 2-O-Ribose RNA Methyltransferase SPB1 Homolog 3 4
  • Putative RRNA Methyltransferase 3 3 4
  • Protein FtsJ Homolog 3 3 4
  • SPB1 RNA Methyltransferase Homolog (S. Cerevisiae) 2
  • RRNA (Uridine-2-O-)-Methyltransferase 3 3
  • SPB1 RNA Methyltransferase Homolog 3
  • EC 2.1.1.- 4
  • EPCS3 3
  • SPB1 3

External Ids for FTSJ3 Gene

Previous GeneCards Identifiers for FTSJ3 Gene

  • GC17M061547
  • GC17M064323
  • GC17M062237
  • GC17M062370
  • GC17M059250
  • GC17M061896
  • GC17M057264

Summaries for FTSJ3 Gene

Entrez Gene Summary for FTSJ3 Gene

  • Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ protein and to a mouse protein possibly involved in embryogenesis. [provided by RefSeq, Jul 2008]

GeneCards Summary for FTSJ3 Gene

FTSJ3 (FtsJ Homolog 3 (E. Coli)) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and rRNA methyltransferase activity.

UniProtKB/Swiss-Prot for FTSJ3 Gene

  • Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.

Gene Wiki entry for FTSJ3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTSJ3 Gene

Genomics for FTSJ3 Gene

Regulatory Elements for FTSJ3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FTSJ3 Gene

Chromosome:
17
Start:
63,819,433 bp from pter
End:
63,830,012 bp from pter
Size:
10,580 bases
Orientation:
Minus strand

Genomic View for FTSJ3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FTSJ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTSJ3 Gene

Proteins for FTSJ3 Gene

  • Protein details for FTSJ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY81-SPB1_HUMAN
    Recommended name:
    pre-rRNA processing protein FTSJ3
    Protein Accession:
    Q8IY81
    Secondary Accessions:
    • B2RCA5
    • D3DU22
    • Q8N3A3
    • Q8WXX1
    • Q9BWM4
    • Q9NXT6

    Protein attributes for FTSJ3 Gene

    Size:
    847 amino acids
    Molecular mass:
    96558 Da
    Quaternary structure:
    • Interacts with NIP7.
    SequenceCaution:
    • Sequence=BAA90924.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for FTSJ3 Gene

Proteomics data for FTSJ3 Gene at MOPED

Post-translational modifications for FTSJ3 Gene

No data available for DME Specific Peptides for FTSJ3 Gene

Domains & Families for FTSJ3 Gene

Suggested Antigen Peptide Sequences for FTSJ3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IY81

UniProtKB/Swiss-Prot:

SPB1_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.
genes like me logo Genes that share domains with FTSJ3: view

No data available for Gene Families for FTSJ3 Gene

Function for FTSJ3 Gene

Molecular function for FTSJ3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2-O-methylnucleoside.
UniProtKB/Swiss-Prot Function:
Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.

Enzyme Numbers (IUBMB) for FTSJ3 Gene

Gene Ontology (GO) - Molecular Function for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21903422
GO:0008168 methyltransferase activity --
GO:0008649 rRNA methyltransferase activity --
GO:0008650 rRNA (uridine-2-O-)-methyltransferase activity IBA --
GO:0016435 rRNA (guanine) methyltransferase activity IBA --
genes like me logo Genes that share ontologies with FTSJ3: view
genes like me logo Genes that share phenotypes with FTSJ3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FTSJ3

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FTSJ3 Gene

Localization for FTSJ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FTSJ3 Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FTSJ3 Gene COMPARTMENTS Subcellular localization image for FTSJ3 gene
Compartment Confidence
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
GO:0030687 preribosome, large subunit precursor IBA --
GO:0030688 preribosome, small subunit precursor IEA --
genes like me logo Genes that share ontologies with FTSJ3: view

Pathways & Interactions for FTSJ3 Gene

SuperPathways for FTSJ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FTSJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000453 enzyme-directed rRNA 2-O-methylation IEA --
GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing --
GO:0031167 rRNA methylation IBA --
genes like me logo Genes that share ontologies with FTSJ3: view

No data available for Pathways by source and SIGNOR curated interactions for FTSJ3 Gene

Drugs & Compounds for FTSJ3 Gene

(2) Drugs for FTSJ3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with FTSJ3: view

Transcripts for FTSJ3 Gene

mRNA/cDNA for FTSJ3 Gene

(1) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(16) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FTSJ3 Gene

FtsJ homolog 3 (E. coli):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FTSJ3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTSJ3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
SP1: - - - - -
SP2: - - - - - - -
SP3: - - -
SP4:
SP5: - - -
SP6:
SP7:
SP8: -
SP9: - -
SP10:
SP11: - -
SP12:
SP13:

ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for FTSJ3 Gene

GeneLoc Exon Structure for
FTSJ3
ECgene alternative splicing isoforms for
FTSJ3

Expression for FTSJ3 Gene

mRNA expression in normal human tissues for FTSJ3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FTSJ3 Gene

This gene is overexpressed in Lung (16.4), Peripheral blood mononuclear cells (12.1), and Adrenal (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FTSJ3 Gene



SOURCE GeneReport for Unigene cluster for FTSJ3 Gene Hs.463785

genes like me logo Genes that share expression patterns with FTSJ3: view

Protein tissue co-expression partners for FTSJ3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for FTSJ3 Gene

Orthologs for FTSJ3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FTSJ3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FTSJ3 35
  • 87.36 (n)
  • 89.27 (a)
FTSJ3 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FTSJ3 35
  • 86.52 (n)
  • 89.05 (a)
FTSJ3 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ftsj3 35
  • 85.25 (n)
  • 88.12 (a)
Ftsj3 16
Ftsj3 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FTSJ3 35
  • 99.37 (n)
  • 99.17 (a)
FTSJ3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ftsj3 35
  • 84.41 (n)
  • 87.03 (a)
oppossum
(Monodelphis domestica)
Mammalia FTSJ3 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJ3 35
  • 69.53 (n)
  • 70.51 (a)
FTSJ3 36
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FTSJ3 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsj3 35
  • 70.98 (n)
  • 76.62 (a)
Str.15904 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3413 35
zebrafish
(Danio rerio)
Actinopterygii ftsj 35
  • 63.82 (n)
  • 63.61 (a)
wufa11d10 35
ftsj 36
  • 61 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.481 35
fruit fly
(Drosophila melanogaster)
Insecta CG8939 37
  • 38 (a)
CG8939 35
  • 51.96 (n)
  • 44.78 (a)
CG8939 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003002 35
  • 52.51 (n)
  • 45.21 (a)
worm
(Caenorhabditis elegans)
Secernentea H06I04.3a 37
  • 55 (a)
H06I04.3b 37
  • 55 (a)
H06I04.3 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SPB1 36
  • 36 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.20336 35
corn
(Zea mays)
Liliopsida Zm.14347 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9297 36
  • 47 (a)
OneToOne
Species with no ortholog for FTSJ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FTSJ3 Gene

ENSEMBL:
Gene Tree for FTSJ3 (if available)
TreeFam:
Gene Tree for FTSJ3 (if available)

Paralogs for FTSJ3 Gene

(2) SIMAP similar genes for FTSJ3 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with FTSJ3: view

No data available for Paralogs for FTSJ3 Gene

Variants for FTSJ3 Gene

Sequence variations from dbSNP and Humsavar for FTSJ3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs752621 -- 63,824,520(+) CAAAA(C/G)GCTCA intron-variant
rs894406 -- 63,824,297(-) TGGAC(C/T)GGGTG intron-variant
rs894407 -- 63,824,281(-) GGGAA(A/G)AGTCT intron-variant
rs2584627 -- 63,824,079(-) GGTGA(A/G)AGGAG intron-variant
rs2665836 -- 63,820,775(-) TTTTT(G/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FTSJ3 Gene

Variant ID Type Subtype PubMed ID
nsv833510 CNV Loss 17160897
nsv510720 CNV Loss 20534489
nsv517272 CNV Gain+Loss 19592680

Variation tolerance for FTSJ3 Gene

Residual Variation Intolerance Score: 24.02% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.85; 67.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FTSJ3 Gene

HapMap Linkage Disequilibrium report
FTSJ3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FTSJ3 Gene

Disorders for FTSJ3 Gene

Relevant External Links for FTSJ3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FTSJ3
genes like me logo Genes that share disorders with FTSJ3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTSJ3 Gene

Publications for FTSJ3 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  4. RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. (PMID: 24639526) Carmon K.S. … Liu Q. (Proc. Natl. Acad. Sci. U.S.A. 2014) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for FTSJ3 Gene

Sources for FTSJ3 Gene

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