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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

FTSJ3 Gene

protein-coding   GIFtS: 47
GCID: GC17M061896

FtsJ homolog 3 (E. coli)

 Explore 2 diseases affiliated with
FTSJ3 via our new
 Human Malady Compendium 
Biological research products
for FTSJ3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
FtsJ Homolog 3 (E. Coli)1 2     Pre-RRNA Processing Protein FTSJ32
SPB11 2     RRNA (Uridine-2'-O-)-Methyltransferase 32
Protein FtsJ Homolog 32 3     SPB1 RNA Methyltransferase Homolog2
Putative RRNA Methyltransferase 32 3     2'-O-Ribose RNA Methyltransferase SPB1 Homolog3
EPCS32     EC 2.1.1.-3

External Ids:    HGNC: 171361   Entrez Gene: 1172462   Ensembl: ENSG000001085927   UniProtKB: Q8IY813   

Export aliases for FTSJ3 gene to outside databases

Previous GC identifers: GC17M061547 GC17M064323 GC17M062237 GC17M062370 GC17M059250 GC17M057264


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for FTSJ3:
Although the function of this gene is not known, the existence of this gene is supported by mRNA and EST data. A
possible function of the encoded protein can be inferred from amino acid sequence similarity to the E.coli FtsJ
protein and to a mouse protein possibly involved in embryogenesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SPB1_HUMAN, Q8IY81
Function: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal
subunit formation

Gene Wiki entry for FTSJ3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.1  NT_010783.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the FTSJ3 gene promoter:
         E2F-3a   E2F-4   E2F-5   POU2F1   Sp1   AML1a   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFTSJ3 promoter sequence
   Search SABiosciences Chromatin IP Primers for FTSJ3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FTSJ3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23

FTSJ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FTSJ3 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M061896:  view genomic region     (about GC identifiers)

Start:
61,896,793 bp from pter      End:
61,907,372 bp from pter
Size:
10,580 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: SPB1_HUMAN, Q8IY81 (See protein sequence)
Recommended Name: pre-rRNA processing protein FTSJ3  
Size: 847 amino acids; 96558 Da
Subunit: Interacts with NIP7
Subcellular location: Nucleus, nucleolus
Sequence caution: Sequence=BAA90924.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RCA5 D3DU22 Q8N3A3 Q8WXX1 Q9BWM4 Q9NXT6

Explore the universe of human proteins at neXtProt for FTSJ3: NX_Q8IY81

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8IY81

  • FTSJ3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_060117.3  
    ENSEMBL proteins: 
     ENSP00000462347   ENSP00000396673   ENSP00000462212   ENSP00000462342   ENSP00000463980  
     ENSP00000462290   ENSP00000464648   ENSP00000464361   ENSP00000463229  

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    Uscn Proteins for FTSJ3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005730nucleolus IEA--


    FTSJ3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    FTSJ3 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015507 rRNA-MeTfrase_E
     IPR024576 rRNA_MeTfrase_Spb1_DUF3381
     IPR012920 rRNA_MeTfrase_Spb1_C
     IPR002877 rRNA_MeTrfase_FtsJ_dom

    Graphical View of Domain Structure for InterPro Entry Q8IY81

    ProtoNet protein and cluster: Q8IY81

    2 Blocks protein families:
    IPB002877 Cell division protein FtsJ
    IPB012920 Spb1


    UniProtKB/Swiss-Prot: SPB1_HUMAN, Q8IY81
    Similarity: Belongs to the methyltransferase superfamily. RlmE family. SPB1 subfamily


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: SPB1_HUMAN, Q8IY81
    Function: Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal
    subunit formation
    Catalytic activity: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methylnucleoside

    Enzyme Number (IUBMB): EC 2.1.1.-1

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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0005515protein binding IPI--
    GO:0008168methyltransferase activity IEA--


    FTSJ3 for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FTSJ3

    5/20 Interacting proteins for FTSJ3 (Q8IY811, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SAT1P216732, 3MINT-66444 I2D: score=4 
    EIF2AK2P195251, 3EBI-744088,EBI-640775 I2D: score=1 
    OAS3Q9Y6K51, 3EBI-744088,EBI-6115729 I2D: score=1 
    MAGEB4O154813I2D: score=3 
    CHN2P527573I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001510RNA methylation IEA--
    GO:0006364rRNA processing IEA--


    FTSJ3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FTSJ3

    1 HMDB Compound for FTSJ3    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--
    Search CenterWatch for drugs/clinical trials and news about FTSJ3 / SPB1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for FTSJ3 gene: 
    NM_017647.3  

    Unigene Cluster for FTSJ3:

    FtsJ homolog 3 (E. coli)
    Hs.463785  [show with all ESTs]
    Unigene Representative Sequence: NM_017647
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582115(uc002jbz.3) ENST00000427159(uc002jca.3) ENST00000583202
    ENST00000583901 ENST00000579831 ENST00000580376 ENST00000580129 ENST00000579569
    ENST00000584193 ENST00000580272 ENST00000581209 ENST00000577263 ENST00000580290
    ENST00000582476 ENST00000584574 ENST00000585145 ENST00000580295

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    Additional cDNA sequence: 

    AF147378.1 AF327355.1 AK000069.1 AK095861.1 AK296715.1 AK307398.1 AK315010.1 AL834482.1 
    BC000131.1 BC036710.2 

    18 DOTS entries:

    DT.100745357  DT.100745437  DT.97855470  DT.86837221  DT.100724310  DT.91723560  DT.102838781  DT.95202158 
    DT.100745450  DT.121007096  DT.100745389  DT.92440817  DT.95070697  DT.121007354  DT.121007509  DT.95070700 
    DT.101964800  DT.102838780 

    11 AceView cDNA sequences:

    AL834482 AK095861 CR614545 BC000131 CR596573 NM_017647 AF327355 BC036710 
    AK000069 AF147378 AK027463 

    GeneLoc Exon Structure

    5/13 Alternative Splicing Database (ASD) splice patterns (SP) for FTSJ3 (see all 13)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a ·
    SP1:                    -     -                 -                       -     -                                                                                 
    SP2:        -     -     -     -                 -                       -     -                                                                                 
    SP3:                                            -                       -     -                                                                                 
    SP4:                                                                                                                                                            
    SP5:                    -     -                 -                                                                                                               

    ExUns: 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24
    SP1:                                                            
    SP2:                                                            
    SP3:                                                            
    SP4:                                                            
    SP5:                                                            


    ECgene alternative splicing isoforms for FTSJ3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    FTSJ3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACCCTTTTTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See FTSJ3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for FTSJ3

    SOURCE GeneReport for Unigene cluster: Hs.463785
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FTSJ3 gene from 9/35 species (see all 35)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves FTSJ31 FtsJ homolog 3 (E. coli) 70.08(n)
    71.05(a)
      419943  NM_001030925.1  NP_001026096.1 
    lizard
    (Anolis carolinensis)
    Reptilia FTSJ36
    --
    64(a)
    1 ↔ 1
    6(71658477-71680206)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.34132 Xenopus laevis transcribed sequence with moderate similarity more 77.97(n)    BQ733528.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa11d102 Danio rerio cDNA clone IMAGE5605243, partial cds 76.66(n)    BC055618.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG89391 , 3 rRNA processing rRNA methyltransferase3
    CG89391
    38(a)3
    51.29(n)1
    43.84(a)1
      14A53
    325681  NM_132871.21  NP_573099.11 
    worm
    (Caenorhabditis elegans)
    Secernentea H06I04.3a3
    H06I04.31
    Protein H06I04.31 55(a)
    (best of 2)3
    50.38(n)1
    42.77(a)1
      III(3142371-3156867)3
    1754141  NM_065254.41  NP_497655.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPB11 Spb1p 47.65(n)
    38.74(a)
      850304   NP_009877.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G257301 FtsJ-like methyltransferase family protein 51.08(n)
    40.68(a)
      828678  NM_118705.2  NP_194303.2 
    rice
    (Oryza sativa)
    Liliopsida Os.203362 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.83(n)    AK101119.1 


    ENSEMBL Gene Tree for FTSJ3 (if available)
    TreeFam Gene Tree for FTSJ3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/176 NCBI SNPs in FTSJ3 are shown (see all 176    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1440462371,2
    C,F--61897196(+) CCTTAA/C/TGTTGC 3 H R L mis12NA EU 5873
    rs1486782821,2
    F--61897255(+) CCTCTG/TACTCC 2 V syn11Minor allele frequency- T:0.00NA 4550
    rs1995649341,2
    --61897258(+) CTGACA/TCCAGC 2 G syn10--------
    rs2017550661,2
    C,--61897290(+) CACACC/GTTTTT 2 R G mis11Minor allele frequency- G:0.00EU 1323
    rs1859738981,2
    C,--61897459(+) ACTTTA/CTCTCG 2 E D mis10--------
    rs1906417561,2
    C,--61897462(+) TTCTCG/TCGTTC 2 R syn10--------
    rs1156668251,2
    C,F,--61897483(+) ACTGTG/CTTCAC 2 /N /K mis12Minor allele frequency- C:0.00WA NA 4772
    rs2005167321,2
    --61897553(+) GTCAGG/TTGACC 1 -- int10--------
    rs2001153141,2
    --61897574(+) CCCCCA/CACCCC 1 -- int10--------
    rs2021842791,2
    --61897604(+) AGGCCC/GCATCA 1 -- int10--------

    HapMap Linkage Disequilibrium report for FTSJ3 (61896793 - 61907372 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for FTSJ3: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    FTSJ3 for disorders           About GeneDecksing

    2 diseases for FTSJ3:    About MalaCards
    homocysteine    malaria


    Export disorders for FTSJ3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for FTSJ3 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with FTSJ3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human nucleolar protein FTSJ3 associates with NIP7 and functions in pre-rRNA processing. (PubMed id 22195017)1, 2 Morello L.G....Zanchin N.I. (2011)
    2. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Functional proteomic analysis of human nucleolus. (PubMed id 12429849)1, 2 Scherl A.... Diaz J.-J. (2002)
    7. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    8. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    9. Targeted ubiquitination and degradation of G-protein-c oupled receptor kinase 5 by the DDB1-CUL4 ubiquitin ligase complex. (PubMed id 22952844)1 Wu Z....Ma L. (2012)
    10. Functional proteomics establishes the interaction of S IRT7 with chromatin remodeling complexes and expands its role in regulation of R NA polymerase I transcription. (PubMed id 22586326)1 Tsai Y.C....Cristea I.M. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117246 HGNC: 17136 AceView: FTSJ3 Ensembl:ENSG00000108592 euGenes: HUgn117246
    ECgene: FTSJ3 H-InvDB: FTSJ3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for FTSJ3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for FTSJ3 gene:
    Search GeneIP for patents involving FTSJ3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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