Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FTSJ2 Gene

Aliases for FTSJ2 Gene

  • FtsJ RNA Methyltransferase Homolog 2 (E. Coli) 2 3
  • 16S RRNA (Uridine(1369)-2-O)-Methyltransferase 3 4
  • 16S RRNA [Um1369] 2-O-Methyltransferase 3 4
  • RRNA (Uridine-2-O-)-Methyltransferase 2 3
  • Protein FtsJ Homolog 2 3 4
  • FJH1 3 4
  • MRM2 3 4
  • MRM2 RNA Methyltransferase Homolog (S. Cerevisiae) 2
  • Putative Ribosomal RNA Methyltransferase 2 3
  • MRM2 RNA Methyltransferase Homolog 3
  • Epididymis Luminal Protein 97 3
  • Cell Division Protein FtsJ 3
  • FtsJ Homolog 2 3
  • EC 2.1.1.- 4
  • HEL97 3
  • RRMJ2 3

External Ids for FTSJ2 Gene

Previous GeneCards Identifiers for FTSJ2 Gene

  • GC07M001918
  • GC07M002018
  • GC07M002047

Summaries for FTSJ2 Gene

Entrez Gene Summary for FTSJ2 Gene

  • The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]

GeneCards Summary for FTSJ2 Gene

FTSJ2 (FtsJ RNA Methyltransferase Homolog 2 (E. Coli)) is a Protein Coding gene. GO annotations related to this gene include methyltransferase activity and rRNA (uridine-2-O-)-methyltransferase activity.

UniProtKB/Swiss-Prot for FTSJ2 Gene

  • S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTSJ2 Gene

Genomics for FTSJ2 Gene

Regulatory Elements for FTSJ2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FTSJ2 Gene

Chromosome:
7
Start:
2,234,231 bp from pter
End:
2,242,198 bp from pter
Size:
7,968 bases
Orientation:
Minus strand

Genomic View for FTSJ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FTSJ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTSJ2 Gene

Proteins for FTSJ2 Gene

  • Protein details for FTSJ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI43-MRM2_HUMAN
    Recommended name:
    rRNA methyltransferase 2, mitochondrial
    Protein Accession:
    Q9UI43
    Secondary Accessions:
    • Q24JR8

    Protein attributes for FTSJ2 Gene

    Size:
    246 amino acids
    Molecular mass:
    27424 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FTSJ2 Gene

neXtProt entry for FTSJ2 Gene

Proteomics data for FTSJ2 Gene at MOPED

Post-translational modifications for FTSJ2 Gene

  • Ubiquitination at Lys 45, Lys 48, and Lys 225
  • Modification sites at PhosphoSitePlus

Other Protein References for FTSJ2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FTSJ2 Gene

Domains & Families for FTSJ2 Gene

Protein Domains for FTSJ2 Gene

Suggested Antigen Peptide Sequences for FTSJ2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UI43

UniProtKB/Swiss-Prot:

MRM2_HUMAN :
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
Family:
  • Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.
genes like me logo Genes that share domains with FTSJ2: view

No data available for Gene Families for FTSJ2 Gene

Function for FTSJ2 Gene

Molecular function for FTSJ2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-adenosyl-L-methionine + uridine(1369) in 16S rRNA = S-adenosyl-L-homocysteine + 2-O-methyluridine(1369) in 16S rRNA.
UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent 2-O-ribose methyltransferase that catalyzes the formation of 2-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.

Enzyme Numbers (IUBMB) for FTSJ2 Gene

Gene Ontology (GO) - Molecular Function for FTSJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008168 methyltransferase activity --
GO:0008650 rRNA (uridine-2-O-)-methyltransferase activity NAS 11827451
genes like me logo Genes that share ontologies with FTSJ2: view

Phenotypes for FTSJ2 Gene

genes like me logo Genes that share phenotypes with FTSJ2: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FTSJ2

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for FTSJ2 Gene

Localization for FTSJ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FTSJ2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FTSJ2 Gene COMPARTMENTS Subcellular localization image for FTSJ2 gene
Compartment Confidence
nucleus 5
mitochondrion 3

Gene Ontology (GO) - Cellular Components for FTSJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA 11827451
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with FTSJ2: view

Pathways & Interactions for FTSJ2 Gene

SuperPathways for FTSJ2 Gene

No Data Available

Interacting Proteins for FTSJ2 Gene

Gene Ontology (GO) - Biological Process for FTSJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000453 enzyme-directed rRNA 2-O-methylation IBA --
GO:0001510 RNA methylation --
GO:0006364 rRNA processing NAS 11827451
GO:0008283 cell proliferation NAS 11827451
GO:0031167 rRNA methylation NAS 11827451
genes like me logo Genes that share ontologies with FTSJ2: view

No data available for Pathways by source and SIGNOR curated interactions for FTSJ2 Gene

Drugs & Compounds for FTSJ2 Gene

(2) Drugs for FTSJ2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
S-Adenosylmethionine Approved Nutra 0
s-adenosylhomocysteine Experimental Pharma 0
genes like me logo Genes that share compounds with FTSJ2: view

Transcripts for FTSJ2 Gene

Unigene Clusters for FTSJ2 Gene

FtsJ RNA methyltransferase homolog 2 (E. coli):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FTSJ2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTSJ2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h
SP1: - - - -
SP2: - - - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - - - - -
SP8: - - - - - - - -
SP9: - - - - - - -
SP10: - - -
SP11: - - - -
SP12: - - - - - -
SP13: - -
SP14: - -
SP15: - - - -
SP16:

Relevant External Links for FTSJ2 Gene

GeneLoc Exon Structure for
FTSJ2
ECgene alternative splicing isoforms for
FTSJ2

Expression for FTSJ2 Gene

mRNA expression in normal human tissues for FTSJ2 Gene

Protein differential expression in normal tissues from HIPED for FTSJ2 Gene

This gene is overexpressed in Cerebrospinal fluid (23.5), Synovial fluid (22.1), Heart (15.3), and Adipocyte (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FTSJ2 Gene



SOURCE GeneReport for Unigene cluster for FTSJ2 Gene Hs.279877

mRNA Expression by UniProt/SwissProt for FTSJ2 Gene

Q9UI43-MRM2_HUMAN
Tissue specificity: Widely expressed, with highest expression in muscle, placenta, and heart.
genes like me logo Genes that share expression patterns with FTSJ2: view

Protein tissue co-expression partners for FTSJ2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for FTSJ2 Gene

Orthologs for FTSJ2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FTSJ2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FTSJ2 35
  • 84.99 (n)
  • 84.71 (a)
FTSJ2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FTSJ2 35
  • 81.51 (n)
  • 80.67 (a)
FTSJ2 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ftsj2 35
  • 80.11 (n)
  • 79.84 (a)
Ftsj2 16
Ftsj2 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia FTSJ2 35
  • 99.05 (n)
  • 98.37 (a)
FTSJ2 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ftsj2 35
  • 79.81 (n)
  • 77.64 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia FTSJ2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves FTSJ2 35
  • 63.68 (n)
  • 61.54 (a)
FTSJ2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FTSJ2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ftsj2 35
  • 61.99 (n)
  • 56.14 (a)
Str.10962 35
zebrafish
(Danio rerio)
Actinopterygii LOC555586 35
  • 60.49 (n)
  • 55.09 (a)
FTSJ2 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9100 35
fruit fly
(Drosophila melanogaster)
Insecta CG11447 37
  • 41 (a)
CG11447 35
  • 50.39 (n)
  • 41.86 (a)
CG11447 36
  • 38 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004177 35
  • 49.4 (n)
  • 41.44 (a)
worm
(Caenorhabditis elegans)
Secernentea F45G2.9 37
  • 41 (a)
F45G2.9 35
  • 49.35 (n)
  • 44.61 (a)
F45G2.9 36
  • 40 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFL117C 35
  • 49.48 (n)
  • 46.35 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B01980g 35
  • 50.51 (n)
  • 42.42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MRM2 35
  • 46.73 (n)
  • 40.2 (a)
MRM2 36
  • 25 (a)
OneToOne
Species with no ortholog for FTSJ2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FTSJ2 Gene

ENSEMBL:
Gene Tree for FTSJ2 (if available)
TreeFam:
Gene Tree for FTSJ2 (if available)

Paralogs for FTSJ2 Gene

genes like me logo Genes that share paralogs with FTSJ2: view

No data available for Paralogs for FTSJ2 Gene

Variants for FTSJ2 Gene

Sequence variations from dbSNP and Humsavar for FTSJ2 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs4721496 -- 2,239,028(+) ATATA(A/T)AATAC intron-variant
rs6951825 -- 2,238,764(+) accct(A/G)tctct intron-variant
rs6962067 -- 2,240,216(+) GACTC(C/T)GTCTC intron-variant
rs6963660 -- 2,237,691(+) ACCTC(A/G)AGGAT intron-variant
rs7787274 -- 2,236,358(+) GTCAA(A/G)AGATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FTSJ2 Gene

Variant ID Type Subtype PubMed ID
dgv7110n71 CNV Loss 21882294
nsv830885 CNV Loss 17160897
nsv830886 CNV Loss 17160897
nsv887274 CNV Loss 21882294
nsv887277 CNV Loss 21882294
nsv887278 CNV Loss 21882294
nsv887279 CNV Loss 21882294

Variation tolerance for FTSJ2 Gene

Residual Variation Intolerance Score: 72.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FTSJ2 Gene

HapMap Linkage Disequilibrium report
FTSJ2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FTSJ2 Gene

Disorders for FTSJ2 Gene

Relevant External Links for FTSJ2

Genetic Association Database (GAD)
FTSJ2
Human Genome Epidemiology (HuGE) Navigator
FTSJ2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FTSJ2
genes like me logo Genes that share disorders with FTSJ2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTSJ2 Gene

Publications for FTSJ2 Gene

  1. Identification and characterization of FTSJ2, a novel human nucleolar protein homologous to bacterial ribosomal RNA methyltransferase. (PMID: 11827451) Ching Y.-P. … Jin D.-Y. (Genomics 2002) 2 23 67
  2. MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. (PMID: 25009282) Rorbach J. … Minczuk M. (Mol. Biol. Cell 2014) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Assignment of 2'-O-methyltransferases to modification sites on the mammalian mitochondrial large subunit 16S rRNA. (PMID: 25074936) Lee K.W. … Bogenhagen D.F. (J. Biol. Chem. 2014) 67
  5. FTSJ2, a heat shock-inducible mitochondrial protein, suppresses cell invasion and migration. (PMID: 24595062) Lai C.W. … Chen C.M. (PLoS ONE 2014) 67

Products for FTSJ2 Gene

Sources for FTSJ2 Gene

Back to Top

Content