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FTSJ1 Gene

protein-coding   GIFtS: 60
GCID: GC0XP048334

FtsJ RNA Methyltransferase Homolog 1 (E. Coli)

(Previous names: mental retardation, X-linked 9, mental retardation, X-linked...)
(Previous symbols: MRX9, MRX44)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
FtsJ RNA Methyltransferase Homolog 1 (E. Coli)1 2     TRMT72
MRX441 2 5     Cell Division Protein2
MRX91 2 5     Putative Ribosomal RNA Methyltransferase 12
2'-O-Ribose RNA Methyltransferase TRM7 Homolog2 3     Putative TRNA (Cytidine(32)/Guanosine(34)-2'-O)-Methyltransferase2
SPB12 5     RRNA (Uridine-2'-O-)-Methyltransferase2
Mental Retardation, X-Linked 441     TRNA Methyltransferase 7 Homolog2
Mental Retardation, X-Linked 91     EC 2.1.1.2053
TRNA Methyltransferase 7 Homolog (S. Cerevisiae)1     Protein FtsJ Homolog 13
CDLIV2     JM235

External Ids:    HGNC: 132541   Entrez Gene: 241402   Ensembl: ENSG000000684387   OMIM: 3004995   UniProtKB: Q9UET63   
ORGUL members:         

Export aliases for FTSJ1 gene to outside databases

Previous GC identifers: GC0XP047137 GC0XP046595 GC0XP047380 GC0XP048090 GC0XP048219 GC0XP045998


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FTSJ1 Gene:
This gene encodes a member of the methyltransferase superfamily. The encoded protein localizes to the nucleolus,
binds to S-adenosylmethionine, and may be involved in the processing and modification of ribosomal RNA. Mutations
in this gene are associated with mental retardation. Alternative splicing results in multiple transcript
variants. (provided by RefSeq, Aug 2013)

GeneCards Summary for FTSJ1 Gene:
FTSJ1 (FtsJ RNA methyltransferase homolog 1 (E. coli)) is a protein-coding gene. Diseases associated with FTSJ1 include fryns syndrome, and mental retardation, x-linked. GO annotations related to this gene include methyltransferase activity.

UniProtKB/Swiss-Prot: TRM7_HUMAN, Q9UET6
Function: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate
tRNAs (By similarity)

Gene Wiki entry for FTSJ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_079573.5  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the FTSJ1 gene promoter:
         E2F-3a   E2F-4   E2F-5   p53   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidFTSJ1 promoter sequence
   Search Chromatin IP Primers for FTSJ1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FTSJ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.23   Ensembl cytogenetic band:  Xp11.23   HGNC cytogenetic band: Xp11.23

FTSJ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FTSJ1 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP048334:  view genomic region     (about GC identifiers)

Start:
48,334,541 bp from pter      End:
48,344,752 bp from pter
Size:
10,212 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRM7_HUMAN, Q9UET6 (See protein sequence)
Recommended Name: Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase  
Size: 329 amino acids; 36079 Da
Secondary accessions: B2RCJ0 O75670
Alternative splicing: 2 isoforms:  Q9UET6-1   Q9UET6-2   

Explore the universe of human proteins at neXtProt for FTSJ1: NX_Q9UET6

Explore proteomics data for FTSJ1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys34
  • Modification sites at PhosphoSitePlus

  • See FTSJ1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001269086.1  NP_036412.1  NP_803188.1  

    ENSEMBL proteins: 
     ENSP00000019019   ENSP00000326948   ENSP00000415457   ENSP00000380103  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR015507 rRNA-MeTfrase_E
     IPR028590 RNA_methyltr_E_Trm7
     IPR002877 rRNA_MeTrfase_FtsJ_dom

    Graphical View of Domain Structure for InterPro Entry Q9UET6

    ProtoNet protein and cluster: Q9UET6

    1 Blocks protein domain: IPB002877 Cell division protein FtsJ

    UniProtKB/Swiss-Prot: TRM7_HUMAN, Q9UET6
    Similarity: Belongs to the methyltransferase superfamily. RlmE family. TRM7 subfamily


    FTSJ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRM7_HUMAN, Q9UET6
    Function: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate
    tRNAs (By similarity)
    Catalytic activity: S-adenosyl-L-methionine + cytidine(32)/guanosine(34) in tRNA = S-adenosyl-L-homocysteine +
    2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA

         Enzyme Number (IUBMB): EC 2.1.1.2051

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008168methyltransferase activity ----
    GO:0008175tRNA methyltransferase activity IEA--
         
    FTSJ1 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for FTSJ1:
     Decreased NANOG protein expres  Decreased OCT4 protein express  Decreased POU5F1-GFP protein e  Decreased viability of wild-ty 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Ftsj1):
     normal 

    FTSJ1 for phenotypes           About GeneDecksing

    Animal Models:
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    Block miRNA regulation of human, mouse, rat FTSJ1 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidFTSJ1 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRM7_HUMAN, Q9UET6: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    cytoskeleton1
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    FTSJ1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FTSJ1
    Interactions:

        Search GeneGlobe Interaction Network for FTSJ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for FTSJ1 (Q9UET63 ENSP000003269484) via UniProtKB, MINT, STRING, and/or I2D (see all 204)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DMWDQ090193, ENSP000002702234I2D: score=2 STRING: ENSP00000270223
    ATP5J2P561343, ENSP000002924754I2D: score=1 STRING: ENSP00000292475
    DNPH1O435983, ENSP000002304314I2D: score=1 STRING: ENSP00000230431
    GDI1P311503, ENSP000003940714I2D: score=1 STRING: ENSP00000394071
    GRSF1Q128493, ENSP000002547994I2D: score=1 STRING: ENSP00000254799
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001510RNA methylation ----
    GO:0032259methylation ----

    FTSJ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for FTSJ1 (TRM7)

    1 HMDB Compound for FTSJ1    About this table
    CompoundSynonyms CAS #PubMed Ids
    S-Adenosylmethionine(3S)-5'-[(3-amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine (see all 16)29908-03-0--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for FTSJ1 gene (3 alternative transcripts): 
    NM_001282157.1  NM_012280.3  NM_177439.2  

    Unigene Cluster for FTSJ1:

    FtsJ RNA methyltransferase homolog 1 (E. coli)
    Hs.23170  [show with all ESTs]
    Unigene Representative Sequence: NM_177439
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492562 ENST00000019019(uc004djn.1) ENST00000348411(uc004djo.1 uc011mlw.1)
    ENST00000485486 ENST00000473235 ENST00000487353 ENST00000490202 ENST00000496365
    ENST00000466371 ENST00000467954 ENST00000475806 ENST00000489599 ENST00000456787
    ENST00000396894
    miRNA
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    hsa-miR-4310 hsa-miR-338-3p hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidFTSJ1 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat FTSJ1
      QuantiFast Probe-based Assays in human, mouse, rat FTSJ1

    Additional mRNA sequence: 

    AF063015.1 AJ005892.1 AK024023.1 AK297486.1 AK315138.1 BC021047.1 BC023584.1 

    15 DOTS entries:

    DT.451749  DT.86852298  DT.100819798  DT.75101686  DT.99934165  DT.100819799  DT.40237252  DT.92438616 
    DT.100717333  DT.95343719  DT.100668150  DT.100819803  DT.91678135  DT.91909433  DT.91970015 

    Selected AceView cDNA sequences (see all 289):

    BM832774 BM788695 AI492153 BU688915 AI985276 BI916106 NM_177439 AA934695 
    BQ005103 BC023584 BQ430757 CR595180 AA884675 CA454429 BM557593 CR613129 
    CN482383 BM127840 CA428909 CR616099 BU149314 AI761283 CA423266 BM983035 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for FTSJ1 (see all 14)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^
    SP1:                                                  -                 -                             -                       -                 -               
    SP2:                                            -     -                 -                             -                       -                 -               
    SP3:                                            -                       -                             -                                                         
    SP4:                                            -     -                 -                             -                                                         
    SP5:                                            -     -     -           -                                                                                       

    ExUns: 12 ^ 13 ^ 14 ^ 15a · 15b · 15c
    SP1:        -                           
    SP2:        -                           
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for FTSJ1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FTSJ1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACTTGATGG
    FTSJ1 Expression
    About this image

    FTSJ1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FTSJ1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.23170

    UniProtKB/Swiss-Prot: TRM7_HUMAN, Q9UET6
    Tissue specificity: Found in fetal brain, lung, liver and kidney. In the adult brain, expressed in amygdala,
    caudate nucleus, corpus callosum, hippocampus and thalamus

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTSJ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for FTSJ1 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ftsj11 , 5 FtsJ homolog 1 (E. coli)1, 5 86.93(n)1
    87.96(a)1
      X (3.73 cM)5
    546321  NM_133991.21  NP_598752.21 
     82386685 
    lizard
    (Anolis carolinensis)
    Reptilia FTSJ16
    FtsJ RNA methyltransferase homolog 1 (E. coli)
    67(a)
    1 ↔ 1
    GL343326.1(763154-775982)
    African clawed frog
    (Xenopus laevis)
    Amphibia ftsj1-A-prov2 Ftsj homolog (E. coli) 76.51(n)    BC049003.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ftsj11 FtsJ homolog 1 (E. coli) 67.69(n)
    77.05(a)
      492512  NM_001007384.2  NP_001007385.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG52201 , 3 rRNA (uridine-2'-O-)-methyltransferase3
    CG52201
    57(a)
    (best of 2)3
    61.04(n)1
    62.03(a)1
      89E103
    420561  NM_142333.21  NP_650590.11 
    worm
    (Caenorhabditis elegans)
    Secernentea R74.71 , 3 R74.71 55(a)3
    56.03(n)1
    60.22(a)1
      III(4276237-4277477)3
    1755431  NM_065442.51  NP_497843.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes TRM7(YBR061C)4
    TRM71
    2'-O-ribose methyltransferase, methylates the 2'-O-ribose more4
    TRM71
    50.88(n)1
    53.68(a)1
      2(365719-364787)4
    8523531, 4  NP_009617.31  NP_009617.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT5G012301 AT5G01230 59.1(n)
    63.12(a)
      830268  NM_180695.2  NP_851026.1 
    rice
    (Oryza sativa)
    Liliopsida Os.75732 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.24(n)    AK103054.1 


    ENSEMBL Gene Tree for FTSJ1 (if available)
    TreeFam Gene Tree for FTSJ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FTSJ1 gene
    1 SIMAP similar gene for FTSJ1 using alignment to 2 protein entries:     TRM7_HUMAN (see all proteins):
    FTSJ3

    FTSJ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for FTSJ1 (see all 185)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1121084051,2
    C,F--45998074(+) GGGGAT/ACTCAC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1929546541,2
    --45998101(+) GTCTTG/TAAGTC 1 -- us2k10--------
    rs1850343791,2
    --48253981(+) ACTATA/GATAAA 2 -- us2k10--------
    rs1902764241,2
    --48254175(+) CAGACA/TGGGAA 2 -- us2k10--------
    rs1819026221,2
    --48254414(+) AGCACC/GGTCCA 3 -- us2k10--------
    rs1493079771,2
    --48255270(+) GAGTGA/GTGGAT 3 -- int1 us2k10--------
    rs22689541,2
    C,F,H--48255367(-) CAACCT/CCACCA 3 -- int1 us2k115Minor allele frequency- C:0.26NS EA NA CSA 1980
    rs1848817921,2
    --48255583(+) GAATAA/GTAAAC 3 -- int1 us2k10--------
    rs599160751,2
    C--48255710(+) CAGGAA/GGCTAG 3 -- int1 us2k10--------
    rs1896055181,2
    --48255828(+) TTGTTA/TGAGGT 3 -- int1 us2k10--------

    HapMap Linkage Disequilibrium report for FTSJ1 (48334541 - 48344752 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for FTSJ1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv528292CNV Gain19592680
    esv32909CNV Gain+Loss17666407

    Human Gene Mutation Database (HGMD): FTSJ1
    Locus Specific Mutation Databases (LSDB): FTSJ1

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300499   
    OMIM disorders: 309549  
    UniProtKB/Swiss-Prot: TRM7_HUMAN, Q9UET6
  • Mental retardation, X-linked 44 (MRX44) [MIM:309549]: A disorder characterized by significantly below
    average general intellectual functioning associated with impairments in adaptive behavior and manifested during
    the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental
    retardation, while syndromic mental retardation presents with associated physical, neurological and/or
    psychiatric manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 11 diseases for FTSJ1:    
    About MalaCards
    fryns syndrome    mental retardation, x-linked    mental retardation    mental retardation, x-linked 17/31, microduplication
    fragile x syndrome    intellectual disability    tuberculosis    pneumonia
    malaria    multiple myeloma    myeloma

    1 disease from the University of Copenhagen DISEASES database for FTSJ1:
    Intellectual disability

    FTSJ1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for FTSJ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mental retardation 42.1 3 18081026 (2), 15162322 (1)
    tuberculosis 37.2 1 20139085 (1)

    Genetic Association Database (GAD): FTSJ1
    Human Genome Epidemiology (HuGE) Navigator: FTSJ1 (2 documents)

    Export disorders for FTSJ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FTSJ1 gene, integrated from 10 sources (see all 45):
    (articles sorted by number of sources associating them with FTSJ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine- binding protein cause nonsyndromic X-linked mental retardation. (PubMed id 15162322)1, 2, 3, 9 Freude K.... Ropers H.-H. (Am. J. Hum. Genet. 2004)
    2. A splice site mutation in the methyltransferase gene FTSJ1 in Xp11.23 is associated with non-syndromic mental retardation in a large Belgian family (MRX9). (PubMed id 15342698)1, 3, 9 Ramser J....Kooy R.F. (J. Med. Genet. 2004)
    3. Genetic variations in FTSJ1 influence cognitive ability in young males in the Chinese Han population. (PubMed id 19012053)1, 4 Gong P....Zhang F. (J. Neurogenet. 2008)
    4. Positive association of the FTSJ1 gene polymorphisms with nonsyndromic X-linked mental retardation in young Chinese male subjects. (PubMed id 18401546)1, 4 Dai L....Zhang F. (J. Hum. Genet. 2008)
    5. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A loss-of-function mutation in the FTSJ1 gene causes nonsyndromic X-linked mental retardation in a Japanese family. (PubMed id 18081026)1, 9 Takano K....Goto Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 24140 HGNC: 13254 AceView: FTSJ1 Ensembl:ENSG00000068438 euGenes: HUgn24140
    ECgene: FTSJ1 H-InvDB: FTSJ1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FTSJ1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=FTSJ1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FTSJ1 gene:
    Search GeneIP for patents involving FTSJ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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