FTO Gene
protein-coding GIFtS: 52
GCID: GC16P053737
|
|
fat mass and obesity associated
| |
Aliases
for FTO gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Fat Mass And Obesity Associated1 2 | | Alpha-Ketoglutarate-Dependent Dioxygenase FTO2 | | KIAA17521 3 | | Protein Fto2 | | Fat Mass And Obesity-Associated Protein2 3 | | EC 1.14.11.-3 | | MGC51491 | | |
Export aliases for FTO gene to outside databasesPrevious GC identifers: GC16U990090 GC16P053475 GC16P053516 GC16P053622 GC16P052295 GC16P039624 |
Summaries
for FTO gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FTO:
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily butthe exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylatedDNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous andcardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. (provided byRefSeq, Jul 2011)
UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1Function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towardssingle-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has lowdemethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activitytowards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen,alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure andenergy homeostasis. Contributes to the regulation of body size and body fat accumulation
Gene Wiki entry for FTO (FTO gene)
|
Genomic Views
for FTO gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FTO gene promoter:
Egr-1 FOXD3 NF-AT MEF-2A S8 NF-AT2 FOXO1a aMEF-2 NF-AT1 FOXO1
Other transcription factors
Search SABiosciences Chromatin IP Primers for FTO
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FTO |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q12.2 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q12.2FTO Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P053737: view genomic region
(about GC identifiers)
Start:
|
53,737,875 bp from pter |
End:
|
54,155,853 bp from pter |
Size:
|
417,979 bases |
Orientation:
|
plus strand |
|
Proteins
for FTO gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1 (See
protein sequence)Recommended Name: Alpha-ketoglutarate-dependent dioxygenase FTO Size: 505 amino acids; 58282 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Monomer. May also exist as homodimer (By similarity)
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=BAB21843.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from  and Proteopedia  for FTO:3LFM (3D)
Secondary accessions: A2RUH1 B2RNS0 Q0P676 Q7Z785Alternative splicing: 4 isoforms: Q9C0B1-1 Q9C0B1-2 Q9C0B1-3 Q9C0B1-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for FTO: NX_Q9C0B1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C0B1
FTO Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001073901.1
ENSEMBL proteins: ENSP00000418823 ENSP00000418424 ENSP00000415636 ENSP00000417422 ENSP00000417843 ENSP00000268349 ENSP00000378142
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
FTO for ontologies About GeneDecksing
FTO Antibody Products:
Assay Products for FTO: |
Protein
Domains /
Families
for FTO gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FTO for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9C0B1ProtoNet protein and cluster: Q9C0B1 UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1Domain: The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found inthe bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As aconsequence, the domain is not detected by protein signature databasesSimilarity: Belongs to the fto family |
Function
for FTO gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1Function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towardssingle-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has lowdemethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Has no activitytowards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Requires molecular oxygen,alpha-ketoglutarate and iron. Contributes to the regulation of the global metabolic rate, energy expenditure andenergy homeostasis. Contributes to the regulation of body size and body fat accumulationEnzyme regulation: Activated by ascorbate. Inhibited by N-oxalylglycine, fumarate and succinate (By similarity)Biophysicochemical properties: pH dependence: Optimum pH is 5.5-6;Enzyme Number (IUBMB): EC 1.14.11.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTO (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTO (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FTO | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FTO |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTO |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008198 | ferrous iron binding |
IDA | -- | | GO:0016702 | oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen |
IEA | -- | | GO:0035515 | oxidative RNA demethylase activity |
IDA | 18775698 | | GO:0035516 | oxidative DNA demethylase activity |
IDA | 18775698 | | GO:0043734 | DNA-N1-methyladenine dioxygenase activity |
IDA | -- |
FTO for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for FTO: Ftotm1Urt Ftotm1.2Pzg Ftotm1.3Pzg
9 MGI mutant phenotypes (inferred from 7 alleles ) (MGI details for Fto):
FTO for phenotypes About GeneDecksing
|
Pathways & Interactions
for FTO gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for FTO
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
3 Interacting proteins for FTO (Q9C0B13 ENSP000004188234) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
FTO for ontologies About GeneDecksing
|
Drugs & Compounds
for FTO gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FTO
Search CenterWatch for drugs/clinical trials and news about FTO
|
Transcripts
for FTO gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FTO gene: NM_001080432.2 Unigene Cluster for FTO: Fat mass and obesity associated Hs.528833 [show with all ESTs]Unigene Representative Sequence: NM_0010804329 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000471389(uc002ehr.3 uc010vha.2 uc010cbz.3 uc002ehs.3)
ENST00000570395 ENST00000464071 ENST00000431610 ENST00000460382 ENST00000463855
ENST00000268349 ENST00000472835 ENST00000394647
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTO (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTO (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FTO (NM_001080432) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FTO | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FTO |
Additional cDNA sequence: AB051539.1 AK096554.1 AK295196.1 BC001284.1 BC003583.1 BC030798.1 BC132892.1 BC137091.1 U79260.1 7 DOTS entries: DT.92421723 DT.99980614 DT.451627 DT.97839626 DT.120723834 DT.95259693 DT.100647408 24/102 AceView cDNA sequences (see all 102): AL709243 BQ426064 F13404 AI659161 AA599311 BF437240 BQ949757 CB960336 BX406351 BF513960 F10991 BU170586 AI282038 AI278722 CR594763 AI745667 Z39140 CB112503 AW292058 BC001284 AI620894 BQ721767 BU171816 BC030798
GeneLoc Exon Structure
|
Expression
for FTO gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FTO expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAGTGCTCT
About this image
See FTO Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FTO
SOURCE GeneReport for Unigene cluster: Hs.528833
UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1Tissue specificity: Ubiquitously expressed, with relatively high expression in adrenal glands and brain; especially inhypothalamus and pituitary
SABiosciences Custom PCR Arrays for FTO
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FTO
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FTO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FTO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FTO | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTO |
Orthologs
for FTO gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for FTO gene from 5/12 species (see all 12) About this table
ENSEMBL Gene Tree for FTO (if available)
TreeFam Gene Tree for FTO (if available) |
Paralogs
for FTO gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FTO gene
FTO for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FTO
PGOHUM00000240025
|
Genomic Variants
for FTO gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1Polymorphism: At least one intronic variation within the gene predisposes to childhood and adult obesity
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FTO (53737875 - 53987875 bp, first 250kb of FTO)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for FTO
2 CNVs: 4955 102286
Human Gene Mutation Database (HGMD): FTO
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FTO |
|
Disorders
/ Diseases
for FTO gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FTO for disorders About GeneDecksing
OMIM gene information: 610966
OMIM disorders: 612938
UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1
Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GDFD)[MIM:612938]. A severe polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severepsychomotor delay, functional brain deficits and characteristic facial dysmorphism. In some patients, structural brainmalformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age of 3years
20/35  diseases for FTO (see all 35): About MalaCardsgrowth retardation, developmental delay, coarse facies, and early death obesity obesity, association with type 2 diabetes mellitus
overnutrition polycystic ovary syndrome arterial calcification anorexia nervosa
diabetes mellitus brain malformations alcohol dependence morbid obesity
gestational diabetes insulin resistance myocardial infarction mental disorders
microcephaly nephropathy cataract pulmonary disease
2 diseases from the University of Copenhagen DISEASES database for FTO:Diabetes mellitus Morbid obesity Human Genome Epidemiology (HuGE) Navigator: FTO (256 documents)
Export disorders for FTO gene to outside databases
|
Publications
for FTO gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FTO gene, integrated from 9 sources (see all 353):
(articles sorted by number of sources associating them with FTO) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. (PubMed id 17434869)1, 2, 3 Frayling T.M.... McCarthy M.I. (2007)
- Crystal structure of the FTO protein reveals basis fo r its substrate specificity. (PubMed id 20376003)1, 2 Han Z....Chai J. (2010)
- Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. (PubMed id 19559399)1, 2 Boissel S....Colleaux L. (2009)
- Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. (PubMed id 18775698)1, 2 Jia G....He C. (2008)
- The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. (PubMed id 17991826)1, 3 Gerken T....Schofield C.J. (2007)
- Variation in FTO contributes to childhood obesity and severe adult obesity. (PubMed id 17496892)1, 2 Dina C.... Froguel P. (2007)
- Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
- Relation of fat-mass and obesity-associated gene polym orphism to fat mass content and body mass index in obese children. (PubMed id 22836643)1 Pyrzak B....Demkow U. (2013)
- Association of the common FTO-rs9939609 polymorphism w ith type 2 diabetes, independent of obesity-related traits in a Vietnamese popul ation. (PubMed id 23142383)1 Binh T.Q....Thanh D.V. (2013)
- Effects of FTO genotype on weight loss and metabolic r isk factors in response to calorie restriction among Japanese women. (PubMed id 22016090)1 Matsuo T....Tanaka K. (2012)
|
External Searches for FTO gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FTO gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FTO gene
(According to HUGE)
About This Section
| |
Specialized Databases showing FTO gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FTO | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for FTO gene:
Search GeneIP for patents involving FTO
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FTO gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for FTO | | OriGene shRNA RFP for FTO | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FTO | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FTO | | | OriGene Protein Over-expression Lysate for FTO | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FTO | | OriGene 3'-UTR Clone for FTO | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTO | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTO | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FTO | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FTO | | OriGene Custom Protein Services for FTO | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FTO | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FTO | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FTO | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FTO | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FTO | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FTO |
| |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTO |
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