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FTO Gene

protein-coding   GIFtS: 58
GCID: GC16P053737

Fat Mass And Obesity Associated

  See FTO-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Fat Mass And Obesity Associated1 2     Alpha-Ketoglutarate-Dependent Dioxygenase FTO2
AlkB Homolog 91 2     Protein Fto2
Fat Mass And Obesity-Associated Protein2 3     EC 1.14.11.-3
Alpha-Ketoglutarate-Dependent Dioxygenase1     KIAA17523
ALKBH92     

External Ids:    HGNC: 246781   Entrez Gene: 790682   Ensembl: ENSG000001407187   OMIM: 6109665   UniProtKB: Q9C0B13   

Export aliases for FTO gene to outside databases

Previous GC identifers: GC16U990090 GC16P053475 GC16P053516 GC16P053622 GC16P052295 GC16P039624


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for FTO Gene:
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase
superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function
to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in
nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2
diabetes. (provided by RefSeq, Jul 2011)

GeneCards Summary for FTO Gene:
FTO (fat mass and obesity associated) is a protein-coding gene. Diseases associated with FTO include growth retardation, developmental delay, coarse facies, and early death, and overnutrition. GO annotations related to this gene include ferrous iron binding and oxidative RNA demethylase activity.

UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1
Function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards
single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has
low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically
demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in
higher eukaryotes. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded
DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global
metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body
fat accumulation

Gene Wiki entry for FTO (FTO gene) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the FTO gene promoter:
         Egr-1   FOXD3   NF-AT   MEF-2A   S8   NF-AT2   FOXO1a   aMEF-2   NF-AT1   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for FTO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat FTO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q12.2

FTO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
FTO gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P053737:  view genomic region     (about GC identifiers)

Start:
53,737,875 bp from pter      End:
54,155,853 bp from pter
Size:
417,979 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1 (See protein sequence)
Recommended Name: Alpha-ketoglutarate-dependent dioxygenase FTO  
Size: 505 amino acids; 58282 Da
Cofactor: Binds 1 Fe(2+) ion per subunit
Subunit: Monomer. May also exist as homodimer (By similarity)
Sequence caution: Sequence=BAB21843.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Selected PDB 3D structures from and Proteopedia for FTO (see all 7):
3LFM (3D)        4IDZ (3D)        4IE0 (3D)        4IE4 (3D)        4IE5 (3D)        4IE6 (3D)    
Secondary accessions: A2RUH1 B2RNS0 Q0P676 Q7Z785
Alternative splicing: 4 isoforms:  Q9C0B1-1   Q9C0B1-2   Q9C0B1-3   Q9C0B1-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for FTO: NX_Q9C0B1

Explore proteomics data for FTO at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys45, Lys48, Lys88, Lys107, Lys121, Lys211, Lys216
  • Modification sites at PhosphoSitePlus

  • See FTO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001073901.1  
    ENSEMBL proteins: 
     ENSP00000418823   ENSP00000418424   ENSP00000415636   ENSP00000417422   ENSP00000417843  
     ENSP00000268349   ENSP00000378142  

    FTO Human Recombinant Protein Products:

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    Novus Biologicals FTO Proteins
    Novus Biologicals FTO Lysate
    Sino Biological Recombinant Protein for FTO
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for FTO

     
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    antibodies-online proteins for FTO (9 products) 

     
    antibodies-online peptides for FTO

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    antibodies-online antibodies for FTO (74 products) 

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    Cloud-Clone Corp. ELISAs for FTO
    Cloud-Clone Corp. CLIAs for FTO
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    antibodies-online kits for FTO (9 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ALKB: Alkylation repair homologs

    2 InterPro protein domains:
     IPR024366 FTO_C
     IPR024367 FTO_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9C0B1

    ProtoNet protein and cluster: Q9C0B1

    UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1
    Domain: The 3D-structure of the Fe2OG dioxygenase domain is similar to that of the Fe2OG dioxygenase domain found
    in the bacterial DNA repair dioxygenase alkB and its mammalian orthologs, but sequence similarity is very low. As
    a consequence, the domain is not detected by protein signature databases
    Similarity: Belongs to the fto family


    Find genes that share domains with FTO           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FTO_HUMAN, Q9C0B1
    Function: Dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. Has highest activity towards
    single-stranded RNA containing 3-methyluracil, followed by single-stranded DNA containing 3-methylthymine. Has
    low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Specifically
    demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in
    higher eukaryotes. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded
    DNA. Requires molecular oxygen, alpha-ketoglutarate and iron. Contributes to the regulation of the global
    metabolic rate, energy expenditure and energy homeostasis. Contributes to the regulation of body size and body
    fat accumulation
    Enzyme regulation: Activated by ascorbate. Inhibited by N-oxalylglycine, fumarate and succinate (By similarity)
    Biophysicochemical properties: pH dependence: Optimum pH is 5.5-6;

         Enzyme Number (IUBMB): EC 1.14.11.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008198ferrous iron binding IDA--
    GO:0035515oxidative RNA demethylase activity IDA18775698
    GO:0035516oxidative DNA demethylase activity IDA18775698
    GO:0043734DNA-N1-methyladenine dioxygenase activity IDA--
         
    Find genes that share ontologies with FTO           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 9 alleles(MGI details for Fto):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  immune system 
     integument  mortality/aging  renal/urinary system  skeleton 

    Find genes that share phenotypes with FTO           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for FTO: Ftotm1Urt Ftotm1.2Pzg Ftotm1.2Rdc Ftotm1.3Pzg

       genOway: Develop your customized and physiologically relevant rodent model for FTO

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    miRTarBase miRNAs that target FTO:
    hsa-let-7b-5p (MIRT052254)

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    6 qRT-PCR Assays for microRNAs that regulate FTO:
    hsa-miR-146a* hsa-miR-593 hsa-miR-130b* hsa-miR-3915 hsa-miR-150 hsa-miR-384
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FTO_HUMAN, Q9C0B1: Nucleus. Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS17991826
    GO:0016607nuclear speck IDA--

    Find genes that share ontologies with FTO           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for FTO
    Interactions:

        GeneGlobe Interaction Network for FTO

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for FTO (Q9C0B13 ENSP000004188234) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4Q8IY923, ENSP000002940084I2D: score=1 STRING: ENSP00000294008
    UBCENSP000003448184STRING: ENSP00000344818
    --Q6FG913I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001659temperature homeostasis IEA--
    GO:0006307DNA dealkylation involved in DNA repair IDA18775698
    GO:0010883regulation of lipid storage IEA--
    GO:0035552oxidative single-stranded DNA demethylation IDA18775698
    GO:0035553oxidative single-stranded RNA demethylation IDA18775698

    Find genes that share ontologies with FTO           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for FTO



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for FTO gene: 
    NM_001080432.2  

    Unigene Cluster for FTO:

    Fat mass and obesity associated
    Hs.528833  [show with all ESTs]
    Unigene Representative Sequence: NM_001080432
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000471389(uc002ehr.3 uc010vha.2 uc010cbz.3 uc002ehs.3)
    ENST00000570395 ENST00000464071 ENST00000431610 ENST00000460382 ENST00000463855
    ENST00000268349 ENST00000472835 ENST00000394647
    miRNA
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    hsa-miR-146a* hsa-miR-593 hsa-miR-130b* hsa-miR-3915 hsa-miR-150 hsa-miR-384
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      QuantiFast Probe-based Assays in human, mouse, rat FTO

    Additional mRNA sequence: 

    AB051539.1 AK096554.1 AK295196.1 BC001284.1 BC003583.1 BC030798.1 BC132892.1 BC137091.1 
    U79260.1 

    7 DOTS entries:

    DT.92421723  DT.99980614  DT.451627  DT.97839626  DT.120723834  DT.95259693  DT.100647408 

    Selected AceView cDNA sequences (see all 102):

    AA599311 BU170586 AI278722 BC001284 CR594763 BF513960 BF437240 F10991 
    F13404 AI394660 BU171816 BX406351 CB112503 BC030798 AI659161 BQ426064 
    AI745667 Z39140 AW292058 AI282038 BQ721767 AL709243 CB960336 BQ949757 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    FTO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAGTGCTCT
    FTO Expression
    About this image


    FTO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Testis (Reproductive System)
    FTO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    FTO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.528833

    UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1
    Tissue specificity: Ubiquitously expressed, with relatively high expression in adrenal glands and brain;
    especially in hypothalamus and pituitary

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for FTO gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Fto1 , 5 fat mass and obesity associated1, 5 85.56(n)1
    87.43(a)1
      8 (44.34 cM)5
    263831  NM_011936.21  NP_036066.21 
     913135325 
    chicken
    (Gallus gallus)
    Aves FTO1 fat mass and obesity associated 66.2(n)
    59.88(a)
      415718  NM_001185147.1  NP_001172076.1 
    lizard
    (Anolis carolinensis)
    Reptilia FTO6
    fat mass and obesity associated
    54(a)
    1 ↔ 1
    LGc(623981-889335)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.342712 Xenopus laevis transcribed sequences 78.23(n)    CF288914.1 
    zebrafish
    (Danio rerio)
    Actinopterygii fto1 fat mass and obesity associated 54.24(n)
    49.7(a)
      553363  XM_001345874.4  XP_001345910.4 


    ENSEMBL Gene Tree for FTO (if available)
    TreeFam Gene Tree for FTO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for FTO gene

    Find genes that share paralogs with FTO           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for FTO
    PGOHUM00000240025


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    FTO_HUMAN, Q9C0B1: At least one intronic variation within the gene predisposes to childhood and adult obesity


    Selected SNPs for FTO (see all 8054)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0632524
    Growth retardation developmental delay coarse facies early death (GDFD)4--see VAR_0632522 R Q mis40--------
    rs358144191,2
    C--39625757(+) CCCAC-/TTTTTT 1 -- int11Minor allele frequency- T:0.00CSA 2
    rs345220721,2
    C--39643572(+) ACCTC-/AAAAAA 1 -- int10--------
    rs1461203171,2
    C--39646919(+) TAAAC-/AG/GA 
            
    ACTCT
    1 -- int10--------
    rs106808021,2
    C--39646920(+) AAACA-/AG/GA 
            
    CTCTA
    1 -- int11CSA 2
    rs71971101,2
    C--39652792(+) tttttA/Tttttt 1 -- int1 trp32Minor allele frequency- T:0.00NA CSA 3
    rs58169031,2
    C--39659945(+) Attac-/TATT  
            
    tattt
    1 -- int10--------
    rs347555341,2
    C--39665577(+) CCCCC-/TCATAT 1 -- int10--------
    rs113544361,2
    C--39679652(+) AAAAA-/AGTTGT 1 -- int10--------
    rs717191811,2
    C--39680996(+) TGTGT-/G/GTGTGTGTG
    TGTGTGTGTGTGTG
    TGTGT
    1 -- int10--------

    HapMap Linkage Disequilibrium report for FTO (53737875 - 53987875 bp, first 250kb of FTO)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for FTO (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2509795CNV Deletion19546169
    esv2671392CNV Deletion23128226
    esv273135CNV Insertion20981092
    esv1018277CNV Insertion17803354
    esv271058CNV Insertion20981092
    nsv827654CNV Loss20364138
    nsv906671CNV Loss21882294
    nsv527247CNV Loss19592680
    nsv906669CNV Loss21882294
    nsv906670CNV Loss21882294

    Human Gene Mutation Database (HGMD): FTO
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing FTO
    DNA2.0 Custom Variant and Variant Library Synthesis for FTO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610966   
    OMIM disorders: 612938  
    UniProtKB/Swiss-Prot: FTO_HUMAN, Q9C0B1
  • Growth retardation developmental delay coarse facies early death (GDFD) [MIM:612938]: A severe
    polymalformation syndrome characterized by postnatal growth retardation, microcephaly, severe psychomotor delay,
    functional brain deficits and characteristic facial dysmorphism. In some patients, structural brain
    malformations, cardiac defects, genital anomalies, and cleft palate are observed. Early death occurs by the age
    of 3 years. Note=The disease is caused by mutations affecting the gene represented in this entry

  • 3 diseases for FTO:    
    About MalaCards
    growth retardation, developmental delay, coarse facies, and early death    overnutrition    obesity

    2 diseases from the University of Copenhagen DISEASES database for FTO:
    Diabetes mellitus     Morbid obesity

    Find genes that share disorders with FTO           About GenesLikeMe

    Genetic Association Database (GAD): FTO
    Human Genome Epidemiology (HuGE) Navigator: FTO (256 documents)

    Export disorders for FTO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for FTO gene, integrated from 10 sources (see all 440):
    (articles sorted by number of sources associating them with FTO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. (PubMed id 17434869)1, 2, 3, 4 Frayling T.M.... McCarthy M.I. (Science 2007)
    2. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. (PubMed id 22002720)1, 2, 3 Jia G....He C. (Nat. Chem. Biol. 2011)
    3. Variation in FTO contributes to childhood obesity and severe adult obesity. (PubMed id 17496892)1, 2, 4 Dina C.... Froguel P. (Nat. Genet. 2007)
    4. Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations. (PubMed id 21544081)1, 4 Dorajoo R....Tai E.S. (Int J Obes (Lond) 2012)
    5. Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations. (PubMed id 22344221)1, 4 Okada Y....Tanaka T. (Nat. Genet. 2012)
    6. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. (PubMed id 22399527)1, 4 Kristiansson K....Salomaa V. (Circ Cardiovasc Genet 2012)
    7. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. (PubMed id 21706003)1, 4 KilpelAoinen T.O....Loos R.J. (Nat. Genet. 2011)
    8. Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004. (PubMed id 21248310)1, 4 KivimAoki M....Batty G.D. (Am. J. Epidemiol. 2011)
    9. Genome-wide association analysis of body mass in chronic obstructive pulmonary disease. (PubMed id 21037115)1, 4 Wan E.S.... . (Am. J. Respir. Cell Mol. Biol. 2011)
    10. A genome-wide association study on obesity and obesity-related traits. (PubMed id 21552555)1, 4 Wang K....Price R.A. (PLoS ONE 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79068 HGNC: 24678 AceView: FTO Ensembl:ENSG00000140718 euGenes: HUgn79068
    ECgene: FTO H-InvDB: FTO

    (According to HUGE)
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    HUGE: KIAA1752

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for FTO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for FTO gene:
    Search GeneIP for patents involving FTO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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