Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FTMT Gene

Aliases for FTMT Gene

  • Ferritin Mitochondrial 2 3 5
  • EC 4 63
  • Mitochondrial Ferritin 3
  • Ferritin H Subunit 3
  • MTF 3

External Ids for FTMT Gene

Previous GeneCards Identifiers for FTMT Gene

  • GC05P121264
  • GC05P121215
  • GC05P116379
  • GC05P121187

Summaries for FTMT Gene

GeneCards Summary for FTMT Gene

FTMT (Ferritin Mitochondrial) is a Protein Coding gene. Diseases associated with FTMT include Friedreich Ataxia and Restless Legs Syndrome. GO annotations related to this gene include ferric iron binding and ferroxidase activity. An important paralog of this gene is FTL.

UniProtKB/Swiss-Prot for FTMT Gene

  • Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Gene Wiki entry for FTMT Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTMT Gene

Genomics for FTMT Gene

Regulatory Elements for FTMT Gene

Genomic Location for FTMT Gene

121,851,955 bp from pter
121,852,833 bp from pter
879 bases
Plus strand

Genomic View for FTMT Gene

Genes around FTMT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTMT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTMT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTMT Gene

Proteins for FTMT Gene

  • Protein details for FTMT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ferritin, mitochondrial
    Protein Accession:

    Protein attributes for FTMT Gene

    242 amino acids
    Molecular mass:
    27538 Da
    Quaternary structure:
    • Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited.

    Three dimensional structures from OCA and Proteopedia for FTMT Gene

neXtProt entry for FTMT Gene

Proteomics data for FTMT Gene at MOPED

Selected DME Specific Peptides for FTMT Gene

Post-translational modifications for FTMT Gene

No Post-translational modifications

Other Protein References for FTMT Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for FTMT Gene

Suggested Antigen Peptide Sequences for FTMT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ferritin-like diiron domain.
  • Belongs to the ferritin family.
  • Contains 1 ferritin-like diiron domain.
  • Belongs to the ferritin family.
genes like me logo Genes that share domains with FTMT: view

No data available for Gene Families for FTMT Gene

Function for FTMT Gene

Molecular function for FTMT Gene

UniProtKB/Swiss-Prot CatalyticActivity:
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O.
UniProtKB/Swiss-Prot Function:
Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.

Enzyme Numbers (IUBMB) for FTMT Gene

Phenotypes for FTMT Gene

MGI mutant phenotypes for FTMT:
inferred from 1 alleles
GenomeRNAi human phenotypes for FTMT:
genes like me logo Genes that share phenotypes with FTMT: view

Animal Models for FTMT Gene

MGI Knock Outs for FTMT:

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FTMT Gene

Localization for FTMT Gene

Subcellular locations from UniProtKB/Swiss-Prot for FTMT Gene


Subcellular locations from

Jensen Localization Image for FTMT Gene COMPARTMENTS Subcellular localization image for FTMT gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for FTMT Gene

Pathways & Interactions for FTMT Gene

SuperPathways for FTMT Gene

No Data Available

Interacting Proteins for FTMT Gene

Gene Ontology (GO) - Biological Process for FTMT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis IEA,IDA 18160053
GO:0008284 positive regulation of cell proliferation IDA 18160053
GO:0055114 oxidation-reduction process IEA --
GO:1904231 positive regulation of succinate dehydrogenase activity IGI 18160053
GO:1904234 positive regulation of aconitate hydratase activity IGI 18160053
genes like me logo Genes that share ontologies with FTMT: view

No data available for Pathways by source and SIGNOR curated interactions for FTMT Gene

Drugs & Compounds for FTMT Gene

(4) Drugs for FTMT Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Pharma 161

(9) Additional Compounds for FTMT Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • Armco iron
  • Carbonyl iron
  • FE
  • Ferrovac e
  • Hematite
  • Fe(III)
  • Ferric ion
  • Iron(3+)
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
  • Dioxygen
  • Molecular oxygen
  • O2
  • Oxygen
  • Oxygen molecule
  • Dihydrogen oxide
  • Steam
genes like me logo Genes that share compounds with FTMT: view

Transcripts for FTMT Gene

mRNA/cDNA for FTMT Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FTMT Gene

Ferritin mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for FTMT Gene

No ASD Table

Relevant External Links for FTMT Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FTMT Gene

mRNA expression in normal human tissues for FTMT Gene

mRNA differential expression in normal tissues according to GTEx for FTMT Gene

This gene is overexpressed in Testis (x52.6).

Protein differential expression in normal tissues from HIPED for FTMT Gene

This gene is overexpressed in Plasma (30.7), Liver (16.9), and Ovary (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for FTMT Gene

SOURCE GeneReport for Unigene cluster for FTMT Gene Hs.105324

mRNA Expression by UniProt/SwissProt for FTMT Gene

Tissue specificity: Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine.
genes like me logo Genes that share expression patterns with FTMT: view

Protein tissue co-expression partners for FTMT Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FTMT Gene

Orthologs for FTMT Gene

This gene was present in the common ancestor of animals.

Orthologs for FTMT Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia FTMT 35
  • 84.16 (n)
  • 78.93 (a)
  • 80 (a)
(Canis familiaris)
Mammalia LOC608550 35
  • 83.68 (n)
  • 79.67 (a)
-- 36
  • 78 (a)
-- 36
  • 78 (a)
(Mus musculus)
Mammalia Ftmt 35
  • 78.76 (n)
  • 77.64 (a)
Ftmt 16
Ftmt 36
  • 78 (a)
(Pan troglodytes)
Mammalia FTMT 35
  • 99.04 (n)
  • 97.93 (a)
  • 98 (a)
(Rattus norvegicus)
Mammalia Ftmt 35
  • 79.61 (n)
  • 77.22 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 40 (a)
-- 36
  • 71 (a)
-- 36
  • 78 (a)
-- 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 61 (a)
(Gallus gallus)
Aves FTH 36
  • 77 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 78 (a)
(Danio rerio)
Actinopterygii zgc:92066 35
  • 67.84 (n)
  • 67.65 (a)
fth1a 36
  • 71 (a)
fth1b 36
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta Fer3HCH 35
  • 54.12 (n)
  • 46.3 (a)
Species with no ortholog for FTMT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FTMT Gene

Gene Tree for FTMT (if available)
Gene Tree for FTMT (if available)

Paralogs for FTMT Gene

Paralogs for FTMT Gene

(4) SIMAP similar genes for FTMT Gene using alignment to 1 proteins: Pseudogenes for FTMT Gene

genes like me logo Genes that share paralogs with FTMT: view

Variants for FTMT Gene

Structural Variations from Database of Genomic Variants (DGV) for FTMT Gene

Variant ID Type Subtype PubMed ID
nsv830469 CNV Gain 17160897

Variation tolerance for FTMT Gene

Residual Variation Intolerance Score: 79.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.22; 40.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FTMT Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for FTMT Gene

Disorders for FTMT Gene

MalaCards: The human disease database

(4) MalaCards diseases for FTMT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
friedreich ataxia
  • friedreich ataxia with retained reflexes
restless legs syndrome
  • wed
sideroblastic anemia
  • anemia sideroblastic
- elite association - COSMIC cancer census association via MalaCards
Search FTMT in MalaCards View complete list of genes associated with diseases

Relevant External Links for FTMT

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with FTMT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FTMT Gene

Publications for FTMT Gene

  1. A human mitochondrial ferritin encoded by an intronless gene. (PMID: 11323407) Levi S. … Drysdale J. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. [Expression of mitochondrial ferritin in K562 leukemic cell during ATRA-induced cell differentiation]. (PMID: 20369475) Sun L. … Yuan L.X. (Sichuan Da Xue Xue Bao Yi Xue Ban 2010) 3 23
  3. Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia. (PMID: 18815198) Campanella A. … Levi S. (Hum. Mol. Genet. 2009) 3 23
  4. Mitochondrial ferritin in the substantia nigra in restless legs syndrome. (PMID: 19816198) Snyder A.M. … Connor J.R. (J. Neuropathol. Exp. Neurol. 2009) 3 23
  5. The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin. (PMID: 18160053) Zanella I. … Arosio P. (Biochim. Biophys. Acta 2008) 3 23

Products for FTMT Gene

Sources for FTMT Gene