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Aliases & Descriptions for FTMT
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| EC 1.16.3.1 3 | | MTF 2 | | MtF 1 |
| | | Descriptions |
|---|
| ferritin H subunit 2 | | ferritin heavy chain-like 2 | | ferritin mitochondrial 2 | | mitochondrial ferritin 2 |
|
| | Search outside databases for aliases for FTMT genePrevious GC identifer: GC05P121264 |
Summaries for FTMT(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation |
Genomic Location for FTMT
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the FTMT gene 
Entrez Gene cytogenetic band: 5q21.3 Ensembl cytogenetic band: 5q23.1 HGNC cytogenetic band: 5q23.1FTMT Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P121215:
(about GC identifiers)
Start:
|
121,215,549 bp from pter |
End:
|
121,216,427 bp from pter |
Size:
|
879 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000005.8 NT_034772.5
| Proteins for FTMT
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7 (See
protein sequence)Recommended Name: Ferritin, mitochondrial precursor Size: 242 amino acids; 27538 Da
Subunit: Homo-oligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity into which the polymeric mineral iron core is deposited
Subcellular location: Mitochondrion
PDB structures from and Proteopedia :1R03 (3D)
 REFSEQ proteins: NP_803431.1
ENSEMBL proteins: ENSP00000313691
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: FTMT 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- | About this table
Antibodies for FTMT: Assays for FTMT: | Protein
Domains/ Families for FTMT(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q8N4E7
ProtoNet protein and cluster: Q8N4E7 3 Blocks protein families: IPB001519 Ferritin IPB008331 Ferritin and Dps IPB014034 Ferritin
UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7Similarity: Belongs to the ferritin familySimilarity: Contains 1 ferritin-like diiron domain | Gene Function for FTMT
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_177478
Applied Biosystems Silencer® siRNAs for FTMT
Sigma-Aldrich siRNA for FTMT  Sigma-Aldrich shRNA for FTMT  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_177478                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_177478                                  untagged cDNA clone in CMV expression vector: NM_177478 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_177478
UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidationCatalytic activity: 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)OEnzyme Number (IUBMB): EC 1.16.3.1 4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for FTMT
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/13 Interacting proteins for FTMT (ENSP000003136913) via UniProtKB, MINT, and/or STRING (see all 13
)About this table
5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7
): About this table
|
Drugs & Compounds for FTMT(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for FTMT 6 Novoseek chemical compound relationships for FTMT gene
About this table
|
Transcripts for FTMT(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_177478
Sigma-Aldrich siRNA for FTMT  Sigma-Aldrich shRNA for FTMT  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_177478 REFSEQ mRNAs for FTMT gene: NM_177478.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_177478               OriGene GFP tagged cDNA clone in CMV expression vector: NM_177478                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_177478                                  untagged cDNA clone in CMV expression vector: NM_177478  Additional cDNA sequence: BC034419.1 1 DOTS entry: DT.95302809 7 AceView cDNA sequences:AA469940 NM_177478 BC034419 AA470110 BX116510 AI024273 AI149710
highest scoring ESTs for FTMT:AA470110 AA469940 AI149710 BC034419 BX116510 AI024273 NM_177478 BI827654 DB473588 DB542363 Unigene Cluster for FTMT: Ferritin mitochondrial Hs.105324 [show with all ESTs]Unigene Representative Sequence: NM_177478
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000321339
|
Expression for FTMT
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| FTMT expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for FTMT
1 / 2 / 3 1 probe-set matching FTMT gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAGTGTGCTC
SOURCE GeneReport for Unigene cluster: Hs.105324 UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7Tissue specificity: Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small intestine |
Orthologs for FTMT
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for FTMT gene from 4 species
About this table Species with no ortholog for FTMT
ENSEMBL Gene Tree for FTMT | Paralogs for FTMT(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for FTMT gene
- FTL2
|
SNPs/Variants for FTMT(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for FTMT (up to first 250kb)
|
Disorders & Mutations for FTMT
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608847
9 Novoseek disease relationships for FTMT gene
About this table
|
Medical News for FTMT(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for FTMT (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/58 PubMed articles for FTMT gene (see all 58
):- A human mitochondrial ferritin encoded by an intronless gene. (PubMed id 11323407)1, 2, 3, 4 Levi S.... Drysdale J. (2001)
- Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala. (PubMed id 15201052)1, 3, 4 Langlois d'Estaintot B.... Arosio P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Mitochondrial ferritin: a new player in iron metabolism. (PubMed id 12547228)1, 3 Drysdale J....Levi S. (2002)
- Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia. (PubMed id 18815198)1, 3 Campanella A....Levi S. (2009)
- Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin. (PubMed id 15755449)1, 3 Bou-Abdallah F....Chasteen N.D. (2005)
- Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia. (PubMed id 12406866)1, 3 Cazzola M....Arosio P. (2003)
- The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin. (PubMed id 18160053)1, 3 Zanella I....Arosio P. (2008)
- Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization. (PubMed id 18076382)3 MacKenzie E.L. and Tsuji Y. (2008)
- p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y. (PubMed id 18372207)3 Faniello M.C....Costanzo F. (2008)
|
Search for FTMT
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing FTMT
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing FTMT
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FTMT(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Ferritin |
|
| | | About This Section
| --
| Services for FTMT(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for FTMT:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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