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FTMT Gene

protein-coding   GIFtS: 49

GC05P121215
ferritin mitochondrial
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 1.16.3.1 3
MTF 2
MtF 1
Descriptions
ferritin H subunit 2
ferritin heavy chain-like 2
ferritin mitochondrial 2
mitochondrial ferritin 2
External Ids
HGNC: 173451
Entrez Gene: 940332
UniProtKB: Q8N4E73
Ensembl: ENSG000001818677
Search outside databases for aliases for FTMT gene

Previous GC identifer: GC05P121264

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron
homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as
ferric hydroxides after oxidation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the FTMT gene  

Entrez Gene cytogenetic band: 5q21.3   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

FTMT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P121215:     (about GC identifiers)

Start:
121,215,549 bp from pter
End:
121,216,427 bp from pter
Size:
879 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000005.8  NT_034772.5  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7 (See protein sequence)
Recommended Name: Ferritin, mitochondrial precursor  
Size: 242 amino acids; 27538 Da
Subunit: Homo-oligomer of 24 subunits. The functional molecule is roughly spherical and contains a
central cavity into which the polymeric mineral iron core is deposited
Subcellular location: Mitochondrion
PDB structures from and Proteopedia :
1R03 (3D)    

REFSEQ proteins: NP_803431.1  

ENSEMBL proteins: 
ENSP00000313691 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Sigma-Aldrich Proteins for FTMT  
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (FTMT)
              OriGene Purified Recombinant Human Protein: FTMT 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005739 mitochondrion IEA--
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Antibodies for FTMT: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Assays for FTMT: 
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Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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5 InterPro domains/families:
 IPR009040 Ferritin-like
 IPR001519 Ferritin_N
 IPR012347 Ferritin_rel
 IPR014034 Ferritin_CS
 IPR008331 Ferritin_Dps


   GeneDecks  FTMT for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q8N4E7

ProtoNet protein and cluster: Q8N4E7

3 Blocks protein families:
IPB001519 Ferritin
IPB008331 Ferritin and Dps
IPB014034 Ferritin


UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7
Similarity: Belongs to the ferritin family
Similarity: Contains 1 ferritin-like diiron domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (FTMT)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (FTMT)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_177478

              Applied Biosystems Silencer® siRNAs for FTMT

              Sigma-Aldrich siRNA for FTMT  
                     Sigma-Aldrich shRNA for FTMT  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_177478
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_177478
                                 untagged cDNA clone in CMV expression vector: NM_177478 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_177478

UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7
Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron
homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as
ferric hydroxides after oxidation
Catalytic activity: 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Enzyme Number (IUBMB): EC 1.16.3.1 

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004322 ferroxidase activity IEA--
GO:0005488 binding IEA--
GO:0008199 ferric iron binding IEA--
GO:0016491 oxidoreductase activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Kegg Pathway  (Kegg details for FTMT):
 hsa00860 Porphyrin and chlorophyll metabolism

   GeneDecks  FTMT for the pathways selected above  
About GeneDecksing

5/13 Interacting proteins for FTMT (ENSP000003136913) via UniProtKB, MINT, and/or STRING (see all 13 )
InteractantInteraction Details
GeneCardExternal ID(s)
FECHENSP000003723263STRING (score=.946)
CPENSP000002646133STRING (score=.935)
MTFMTENSP000002200583STRING (score=.91)
PLGENSP000003089383STRING (score=.826)
TFCP2ENSP000002579153STRING (score=.75)
About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO IDQualified GO termEvidencePubMed IDs
GO:0006826 iron ion transport IEA--
GO:0006879 cellular iron ion homeostasis IEA--
GO:0008284 positive regulation of cell proliferation IDA18160053
GO:0051347 positive regulation of transferase activity IDA18160053
GO:0051349 positive regulation of lyase activity IDA18160053
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FTMT
6 Novoseek chemical compound relationships for FTMT gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
iron 69.38 93 12547228 (9), 18691669 (8), 18815198 (7), 15282205 (6) (see all 21)
iron-sulfur 41.19 1 15282205 (1)
endotoxin 34.20 6 11469787 (1), 12801518 (1), 11429389 (1), 12139748 (1)
deferoxamine 33.97 5 10691965 (4)
sulfur 17.53 2 18560166 (1), 18560167 (1)
atp 12.03 2 11033347 (1), 18815198 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (FTMT)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (FTMT)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_177478

              Sigma-Aldrich siRNA for FTMT  
                     Sigma-Aldrich shRNA for FTMT  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_177478  

REFSEQ mRNAs for FTMT gene: 

NM_177478.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_177478  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_177478
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_177478
                                 untagged cDNA clone in CMV expression vector: NM_177478 

Additional cDNA sequence: BC034419.1 

1 DOTS entry:

DT.95302809 

7 AceView cDNA sequences:

AA469940 NM_177478 BC034419 AA470110 BX116510 AI024273 AI149710 

highest scoring ESTs for FTMT:

AA470110 AA469940 AI149710 BC034419 BX116510 AI024273 NM_177478 BI827654 DB473588 DB542363 

Unigene Cluster for FTMT:

Ferritin mitochondrial
Hs.105324  [show with all ESTs]
Unigene Representative Sequence: NM_177478


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000321339  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FTMT expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for FTMT

1 / 2 / 3

1 probe-set matching FTMT gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

42315_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA470110 1.00 1.00 1.00 1
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GAGTGTGCTC

SOURCE GeneReport for Unigene cluster: Hs.105324

UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7
Tissue specificity: Detected in testis and erythroleukemia. Expression is very low or not
detectable in brain, colon, heart, kidney, liver, lung, muscle, placental, spleen and small
intestine

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for FTMT gene from 4 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
chimpanzee
(Pan troglodytes)
FTMT1   -- ferritin mitochondrial 99.04(n)
97.93(a)
471613  XM_526991.2  XP_526991.2 
cow
(Bos taurus)
FTMT1   -- ferritin mitochondrial 84.16(n)
78.93(a)
539838  NM_001076190.1  NP_001069658.1 
rat
(Rattus norvegicus)
Ftmt1   -- ferritin mitochondrial 79.66(n)
77.54(a)
291470  XM_225772.4  XP_225772.4 
mouse
(Mus musculus)
Ftmt1, 5 185
ferritin mitochondrial1, 5 78.67(n)1
77.54(a)1
676341  NM_026286.21  NP_080562.11 
 AK0153465  AK0154005  (see all 8)
About this table        Species with no ortholog for FTMT

ENSEMBL Gene Tree for FTMT
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for FTMT gene
FTL2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/12 NCBI SNPs in FTMT are shown (see all 12 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 22)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 5 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs77205021,2
A,C,F,H121215396(+) TCCCCA/GGCGCC 1 -- ng513Minor allele frequency- G:0.26EU EA 298
rs133587151,2
C,F,H121216508(+) GGTAAC/TTATGG 1 -- ng314Minor allele frequency- T:0.04EU EA WA 418
--
rs349911991,2
--121216038(+) CATGG-/CAGTGT 1 E/R fra10--------
--
rs583410921,2
--121216637(+) GCCTGC/TCATAT 1 -- ng310--------
--
rs737921471,2
--121214241(+) TGTATA/GTCAAT 1 -- ng510--------
rs286204341,2
--121214362(+) AATAGC/TAATCT 1 -- ng510--------
--
rs623824441,2
--121216891(+) TTAACA/GTTTTA 1 -- ng310--------
--
rs125177301,2
--121214811(+) tagtaA/Gagacg 1 -- ng510--------
--
rs361076841,2
--121214470(+) CTAAA-/ATGCTA 1 -- ng510--------
--
rs345761281,2
--121216457(+) CTTTT-/TACTAA 1 -- ng310--------
About this table

HapMap Linkage Disequilibrium images for FTMT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608847

9 Novoseek disease relationships for FTMT gene

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
anemia sideroblastic 88.67 6 12406866 (4), 15282205 (1), 18160053 (1)
friedreich ataxia 80.06 2 18815198 (2)
anemia refractory 50.23 1 12406866 (1)
cerebral vasospasm 45.70 1 11680510 (1)
iron overload 45.67 3 15282205 (2), 15747401 (1)
melanoma 40.33 17 19017294 (5), 8836133 (3), 10691965 (3), 11033347 (2) (see all 7)
myelodysplastic syndromes 36.60 1 15755901 (1)
vasospasm 32.60 4 9303007 (3)
cerebral infarction 24.49 2 9303007 (2)
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(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/58 PubMed articles for FTMT gene (see all 58 ):
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 94033 HGNC: 17345 AceView: FTMT Ensembl:ENSG00000181867 euGenes: HUgn94033
ECgene: FTMT H-InvDB: FTMT
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
Wikipedia http://en.wikipedia.org/wiki/Ferritin
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for FTMT:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Explore super-pooled esiRNAs Proteins for FTMT
 Lentivirus-delivered shRNAs for FTMT Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 shRNA in GFP-retroviral vector
 Search Tocris compounds for FTMT




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for FTMT

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