FTMT Gene
protein-coding GIFtS: 51
GCID: GC05P121215
|
|
ferritin mitochondrial
| |
Aliases
for FTMT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ferritin Mitochondrial1 2 | | Ferritin H Subunit2 | | EC 1.16.3.13 8 | | Ferritin, Mitochondrial2 | | MtF1 | | Mitochondrial Ferritin2 | | MTF2 | | |
Export aliases for FTMT gene to outside databasesPrevious GC identifers: GC05P121264 GC05P116379 |
Summaries
for FTMT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidaseactivity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation
Gene Wiki entry for FTMT (Mitochondrial ferritin)
|
Genomic Views
for FTMT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_034772.6
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FTMT gene promoter:
c-Fos TBP AP-1 Pax-6 RORalpha2 YY1 AREB6 Pax-3 c-Myb Zic3
Other transcription factors
Search SABiosciences Chromatin IP Primers for FTMT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FTMT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q21.3 Ensembl cytogenetic band: 5q23.1 HGNC cytogenetic band: 5q23.1FTMT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P121215: view genomic region
(about GC identifiers)
Start:
|
121,187,650 bp from pter |
End:
|
121,188,528 bp from pter |
Size:
|
879 bases |
Orientation:
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plus strand |
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Proteins
for FTMT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7 (See
protein sequence)Recommended Name: Ferritin, mitochondrial precursor Size: 242 amino acids; 27538 Da
Subunit: Homooligomer of 24 subunits. The functional molecule is roughly spherical and contains a central cavity intowhich the polymeric mineral iron core is deposited
Subcellular location: Mitochondrion
1 PDB 3D structure from  and Proteopedia  for FTMT:1R03 (3D)
Explore the universe of human proteins at neXtProt for FTMT: NX_Q8N4E7
4/5 DME Specific Peptides for FTMT (Q8N4E7) (see all 5)
FTMT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_803431.1
ENSEMBL proteins: ENSP00000313691
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
FTMT for ontologies About GeneDecksing
FTMT Antibody Products:
Assay Products for FTMT: |
Protein
Domains /
Families
for FTMT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FTMT for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q8N4E7ProtoNet protein and cluster: Q8N4E7 3 Blocks protein families: IPB001519 Ferritin IPB008331 Ferritin and Dps IPB014034 Ferritin
UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7Similarity: Belongs to the ferritin familySimilarity: Contains 1 ferritin-like diiron domain |
Function
for FTMT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidaseactivity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidationCatalytic activity: 4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)OEnzyme Number (IUBMB): EC 1.16.3.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTMT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTMT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for FTMT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FTMT |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTMT |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004322 | ferroxidase activity |
IEA | -- | | GO:0008199 | ferric iron binding |
IEA | -- |
FTMT for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ftmttm1Mdf for FTMT
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ftmt):
FTMT for phenotypes About GeneDecksing
|
Pathways & Interactions
for FTMT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Mineral absorption | | | 2 | Glucuronidation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for FTMT):
FTMT for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FTMT
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for FTMT (ENSP000003136914) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table
FTMT for ontologies About GeneDecksing
|
Drugs & Compounds
for FTMT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
FTMT for compounds About GeneDecksing
 Browse Tocris compounds for FTMT
4 HMDB Compounds for FTMT About this table
7 Novoseek chemical compound relationships for FTMT gene About this table
Search CenterWatch for drugs/clinical trials and news about FTMT
|
Transcripts
for FTMT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FTMT gene: NM_177478.1 Unigene Cluster for FTMT: Ferritin mitochondrial Hs.105324 [show with all ESTs]Unigene Representative Sequence: NM_1774781 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000321339(uc003kss.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTMT (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTMT
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FTMT (NM_177478) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FTMT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FTMT |
Additional cDNA sequence: BC034419.1 1 DOTS entry: DT.95302809 7 AceView cDNA sequences: AA469940 BX116510 AA470110 BC034419 NM_177478 AI024273 AI149710
GeneLoc Exon Structure
|
Expression
for FTMT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FTMT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGTGTGCTC
About this image
See FTMT Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.105324
UniProtKB/Swiss-Prot: FTMT_HUMAN, Q8N4E7Tissue specificity: Detected in testis and erythroleukemia. Expression is very low or not detectable in brain, colon,heart, kidney, liver, lung, muscle, placental, spleen and small intestine
SABiosciences Custom PCR Arrays for FTMT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FTMT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat FTMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FTMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FTMT | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTMT |
Orthologs
for FTMT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FTMT gene from 9/24 species (see all 24) About this table
ENSEMBL Gene Tree for FTMT (if available)
TreeFam Gene Tree for FTMT (if available) |
Paralogs
for FTMT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FTMT gene
- FTHL172 FTH12 FTL2
4 SIMAP similar genes for FTMT using alignment to 1 protein entry: FTMT_HUMAN:FTH1 FTH1P19 FTHL17 FTL
FTMT for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FTMT
PGOHUM00000244158
|
Genomic Variants
for FTMT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FTMT (121187650 - 121188528 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for FTMT: --
Human Gene Mutation Database (HGMD): FTMT
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for FTMT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FTMT for disorders About GeneDecksing
OMIM gene information: 608847
OMIM disorders: --
15  diseases for FTMT: About MalaCardshallervorden-spatz syndrome iron overload restless legs syndrome friedreich ataxia
sideroblastic anemia cerebral infarction myelodysplastic syndrome anemia
cerebritis ataxia alzheimer's disease ovarian cancer
cardiomyopathy melanoma hypoxia
2 diseases from the University of Copenhagen DISEASES database for FTMT:Friedreich ataxia Hallervorden-Spatz syndrome 9 Novoseek disease relationships for FTMT gene About this table
Human Genome Epidemiology (HuGE) Navigator: FTMT (2 documents)
Export disorders for FTMT gene to outside databases
|
Publications
for FTMT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FTMT gene, integrated from 9 sources (see all 72):
(articles sorted by number of sources associating them with FTMT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A human mitochondrial ferritin encoded by an intronless gene. (PubMed id 11323407)1, 2, 3, 9 Levi S.... Drysdale J. (2001)
- Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala. (PubMed id 15201052)1, 2, 9 Langlois d'Estaintot B.... Arosio P. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mitochondrial ferritin: a new player in iron metabolism. (PubMed id 12547228)1, 9 Drysdale J....Levi S. (2002)
- Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia. (PubMed id 18815198)1, 9 Campanella A....Levi S. (2009)
- Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin. (PubMed id 15755449)1, 9 Bou-Abdallah F....Chasteen N.D. (2005)
- Mitochondrial ferritin in the substantia nigra in res tless legs syndrome. (PubMed id 19816198)1, 9 Snyder A.M....Connor J.R. (2009)
- Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia. (PubMed id 12406866)1, 9 Cazzola M....Arosio P. (2003)
- [Expression of mitochondrial ferritin in K562 leukemi c cell during ATRA-induced cell differentiation] (PubMed id 20369475)1, 9 Sun L....Yuan L.X. (2010)
- The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin. (PubMed id 18160053)1, 9 Zanella I....Arosio P. (2008)
|
External Searches for FTMT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing FTMT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FTMT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FTMT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FTMT | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Ferritin |
|
| | |
About This Section
| Patent Information for FTMT gene:
Search GeneIP for patents involving FTMT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FTMT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for FTMT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for FTMT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FTMT | | | OriGene Protein Over-expression Lysate for FTMT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for FTMT | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTMT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTMT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for FTMT | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for FTMT | | OriGene Custom Protein Services for FTMT | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat FTMT | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FTMT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FTMT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat FTMT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FTMT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FTMT |
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| |  |  |  |  | | | | |
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 | | | FTMT Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for FTMT |
|  |  |  | | | | Search ThermoFisher Antibodies for FTMT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FTMT |
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