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FTL Gene

protein-coding GIFtS: 65

GC19P054160

ferritin, light polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC71996 ^¹, ²

Descriptions
Ferritin L subunit ^², ³
L apoferritin ^²
ferritin L-chain ^²
ferritin light chain ^²
ferritin light polypeptide-like 3 ^²
ferritin, light polypeptide ^²

External Ids
HGNC: 3999¹
Entrez Gene: 2512²
UniProtKB: P02792³
Ensembl: ENSG00000087086⁷

Search outside databases for aliases for FTL gene

Previous GC identifers: GC19P050126 GC19P049836 GC19P054145

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for FTL:

This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular

iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and

light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron

uptake and release in different tissues. A major function of ferritin is the storage of iron in a

soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several

neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple

pseudogenes. [provided by RefSeq]

UniProtKB/Swiss-Prot: FRIL_HUMAN, P02792

Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron

homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after

oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells

of the developing kidney (By similarity)

Gene Wiki entry for FTL (Ferritin_light_chain)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the FTL gene

Entrez Gene cytogenetic band: 19q13.3-q13.4|19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3-q13.4

FTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P054160: (about GC identifiers)

Start:	54,160,378 bp from pter
End:	54,161,948 bp from pter
Size:	1,571 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: FRIL_HUMAN, P02792 (See protein sequence)

Recommended Name: Ferritin light chain

Size: 175 amino acids; 20020 Da

Subunit: Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy)

chain. The major chain can be light or heavy, depending on the species and tissue type. The

functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a

central cavity into which the insoluble mineral iron core is deposited

PDB structures from and Proteopedia :

2FFX (3D)

2FG4 (3D)

2FG8 (3D)

Secondary accessions: Q7Z2W1 Q9BTZ8

REFSEQ proteins: NP_000137.2

ENSEMBL proteins:

ENSP00000366525

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for FTL
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Ferritin Light Chain, Ferritin)
	Human Recombinant Proteins from Abnova (FTL)

OriGene Purified Recombinant Human Protein: FTL

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008043	intracellular ferritin complex	TAS	7492760
GO:0022627	cytosolic small ribosomal subunit	IDA	8706699

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Antibodies for FTL:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for FTL
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Ferritin Light Chain, Ferritin), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FTL)
	Novus Biologicals Antibodies for FTL

Assays for FTL:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P02792

ProtoNet protein and cluster: P02792

3 Blocks protein families:

IPB001519 Ferritin

IPB008331 Ferritin and Dps

IPB014034 Ferritin

UniProtKB/Swiss-Prot: FRIL_HUMAN, P02792

Similarity: Belongs to the ferritin family

Similarity: Contains 1 ferritin-like diiron domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FTL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FTL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000146

Applied Biosystems Silencer® siRNAs for FTL

Sigma-Aldrich siRNA and siRNA Panels for FTL

Sigma-Aldrich shRNA for FTL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for FTL
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000146
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000146
untagged cDNA clone in CMV expression vector: NM_000146

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000146

UniProtKB/Swiss-Prot: FRIL_HUMAN, P02792

Function: Stores iron in a soluble, non-toxic, readily available form. Important for iron

homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after

oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells

of the developing kidney (By similarity)

Genatlas biochemistry entry for FTL:

ferritin,light polypeptide,19kDa,19.9kDa,non-storage protein

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008199	ferric iron binding	IEA	--
GO:0016491	oxidoreductase activity	IEA	--
GO:0042802	identical protein binding	IPI	16169070

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

3 Sigma-Aldrich "Your Favorite Gene" Pathways for FTL (Your Favorite Gene powered by Ingenuity)

Acute Phase Response Signaling
Xenobiotic Metabolism Signaling
NRF2-mediated Oxidative Stress Response

GeneDecks FTL for the pathways selected above

About GeneDecksing

5/49 Interacting proteins for FTL (ENSP00000366525³ P02792^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 49 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NAMPT	P43490²	STRING (score=.793) MINT-6538799 MINT-6538712 MINT-6538862
FTL	P02792¹^,²	EBI-713279, EBI-713279 MINT-68335 MINT-63355 EBI-713279, EBI-713279 MINT-68335 MINT-63355
FTH1	P02794¹	EBI-713279, EBI-713259
MPHOSPH6	Q99547¹	EBI-713279, EBI-373187
FTL	P02792¹^,²	EBI-713279, EBI-713279 MINT-68335 MINT-63355 EBI-713279, EBI-713279 MINT-68335 MINT-63355

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006826	iron ion transport	IEA	--
GO:0006879	cellular iron ion homeostasis	TAS	7492760

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for FTL
10/11 Novoseek chemical compound relationships for FTL gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
iron	83.76	129	16217041 (3), 1463463 (3), 7647009 (3), 10366790 (2) (see all 63)
ferrozine	61.22	1	10471599 (1)
deferoxamine	46.49	2	10477743 (1)
fe3+	38.44	1	16790936 (1)
haem	27.62	1	1332674 (1)
oxygen	14.77	4	17084901 (1)
cholesterol	0.00	1	10924274 (1)
lipid	0.00	1	2269341 (1)
calcium	0.00	1	14987256 (1)
zinc	0.00	1	9374104 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (FTL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FTL)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000146

Sigma-Aldrich siRNA and siRNA Panels for FTL

Sigma-Aldrich shRNA for FTL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000146

REFSEQ mRNAs for FTL gene:

NM_000146.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000146

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000146
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000146
                                 untagged cDNA clone in CMV expression vector: NM_000146

Additional cDNA sequence: Y09188.1

24/157 DOTS entries (see all 157 ):

DT.97847999 DT.91660269 DT.99926648 DT.92326693 DT.454800 DT.101987514 DT.95274251 DT.95222760

DT.91917348 DT.100735710 DT.91972745 DT.101987515 DT.91972273 DT.95274267 DT.91683650 DT.95274349

DT.100735777 DT.97848029 DT.95274163 DT.99926645 DT.121458314 DT.91972068 DT.100735694 DT.100735761

24/32 AceView cDNA sequences (see all 32 ):

AF147331 CR596451 AK130205 AK131048 Y09188 CR608406 AK130191 AK131050

BC004245 BC002991 CR610876 NM_000146 AK131053 BC067772 BX571748 M12938

BC021670 BC016346 BC018990 CR456715 AK026534 BC062708 AY466472 BC016354

highest scoring ESTs for FTL:

M10119 AA010494 AA025048 AA026532 AA029346 AA031582 AA034969 AA035281 AA036640 AA036903

Unigene Clusters for FTL:

Ferritin, light polypeptide

Hs.433670 [show with all ESTs], Hs.713706 [show with all ESTs]

Unigene Representative Sequences: BF244604, BM918687

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for FTL

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b
SP1:							-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for FTL

1 Ensembl transcript including schematic representation:

ENST00000331825

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

FTL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for FTL

¹ / ² / ³

8 probe-sets matching FTL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35083_at²^{, 3}	U95-A	9	1.00	0.55	0.97	0.98	M10119	1.00	0.90	0.95	1
43423_s_at²^{, 3}	U95-B	7	1.00	0.34	0.98	1.02	AW026066	0.60	0.83	0.73	1
212788_x_at²^{, 3}	U133-A	8	1.00	0.48	--	--	BG537190	0.60	1.00	0.82	1
213187_x_at²^{, 3}	U133-A	7	1.00	0.38	--	--	BG538564	0.40	1.00	0.76	1
220856_x_at²	U133-A	4	0.36	0.50	--	--	--	--	--	--	--
212788_x_at²	U133Plus2	8	1.00	0.48	--	--	--	--	--	--	--
213187_x_at²	U133Plus2	7	1.00	0.38	--	--	--	--	--	--	--
220856_x_at²	U133Plus2	4	0.36	0.50	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCCTGGGTTC

SOURCE GeneReport for Unigene clusters: Hs.433670 Hs.713706
Expression variation in blood from EXPOLDB for FTL

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for FTL gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	FTL¹	--	ferritin, light polypeptide	88.19(n) 86.86(a)	477042 NM_001024636.1 NP_001019807.1
chimpanzee (Pan troglodytes)	LOC747113¹	--	hypothetical protein LOC747113	99.81(n) 99.43(a)	747113 XM_001155938.1 XP_001155938.1
cow (Bos taurus)	LOC782921¹	--	similar to ferritin L subunit	87.24(n) 84(a)	782921 XM_001251063.1 XP_001251064.1
rat (Rattus norvegicus)	Ftl¹	--	ferritin, light polypeptide	85.33(n) 84.57(a)	29292 NM_022500.3 NP_071945.3
mouse (Mus musculus)	Ftl1⁵ Ftl2¹	7⁵	ferritin light chain 1⁵ ferritin light chain 2¹	84.76(n)¹ 82.86(a)¹	14337¹ NM_008049.2¹ NP_032075.2¹ AK002242⁵ AK002253⁵ (see all 50)

About this table Species with no ortholog for FTL

ENSEMBL Gene Tree for FTL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for FTL gene

FTMT²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/74 NCBI SNPs in FTL are shown (see all 74 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs11553199^1,2	H	54160509(+)	`CTTCTC/TGGCCA`	1	--	ut5¹ ese³		4		EU EA WA	406
--	rs11553245^1,2	H	54160490(+)	`TTGCAA/GCCTCC`	1	--	ut5¹ ese³		4		EU EA WA	404
--	rs11553204^1,2	H	54160514(+)	`CGGCCA/GTCTCC`	1	--	ut5¹ ese³		4		EU EA WA	386
--	rs11553209^1,2	C	54161432(+)	`AGGCCC/TTTTGG`	1	L/P	mis¹ ese³		0	--	--	--	--
--	rs11553267^1,2	H	54160521(+)	`CTCCTG/TCTTCT`	1	--	ut5¹ ese³		4		EU EA WA	402
	rs2230267^1,2	C,F,H,O	54160899(+)	`GCGAAT/CTGGCC`	1	L/L	syn¹		8		MN EA NA EU WA	2172
--	rs11553258^1,2	--	54160472(+)	`CTCCGA/GTTTCC`	1	--	ut5¹		0	--	--	--	--
--	rs73577720^1,2	--	54160164(+)	`CCCCCA/CCAAGC`	1	--	ng5¹		0	--	--	--	--
--	rs11553203^1,2	--	54160535(+)	`ACCTGC/TCAGCA`	1	--	ut5¹		0	--	--	--	--
--	rs17851905^1,2	--	54160957(+)	`GCGTGG/TCGGCC`	1	G/V	mis¹ ese³		0	--	--	--	--

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HapMap Linkage Disequilibrium images for FTL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 134790 disorders: 600886 606159

UniProtKB/Swiss-Prot: FRIL_HUMAN, P02792

Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS)

[MIM:600886]. It is an autosomal dominant disease characterized by early-onset bilateral cataract.

Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the

iron responsive element (IRE) of the FTL gene

Defects in FTL are the cause of neuroferritinopathy [MIM:606159]; also known as

adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations

starting in the fourth to sixth decade. It is characterized by a variety of neurological signs

including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and

episodic psychosis. It is linked with decreased serum ferritin levels

10/16 Novoseek disease relationships for FTL gene (see all 16 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
hyperferritinemia-cataract syndrome	96.07	4	10366790 (1), 16406710 (1), 10592329 (1)
iron overload	83.12	4	10759702 (1), 19176363 (1), 1951088 (1)
cataract	66.70	16	17927936 (2), 16518306 (2), 15861269 (2), 16406710 (1) (see all 13)
hemochromatosis	53.69	1	17951290 (1)
nuclear cataract	43.68	1	10753629 (1)
iron deficiency	43.09	2	7647009 (2)
anemia	32.62	2	12230229 (1)
movement disorders	31.71	1	16822677 (1)
genetic disorder	27.42	2	10746272 (1), 10592329 (1)
metastatic melanoma	13.56	1	16252260 (1)

About this table

GeneTests: FTL

Neuroferritinopathy

Human Gene Mutation Database: FTL
Genetic Association Database: FTL
Human Genome Epidemiology Navigator: FTL (8 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/195 PubMed articles for FTL gene (see all 195 ):

Screening for mutations of the ferritin light and heavy genes in Parkinson's disease patients with hyperechogenicity of the substantia nigra. (PubMed id 14615048)^{1, 3, 6} Felletschin B....Berg D. (2003)
Neuroferritinopathy: missense mutation in FTL causing early-onset bilateral pallidal involvement. (PubMed id 16116125)^{3, 4} Maciel P.... Santos M.M. (2005)
Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene. (PubMed id 15099026)^{3, 6} Vidal R.... Delisle M.B. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Screening of ferritin light polypeptide 460-461InsA mutation in Parkinson's disease patients in North America. (PubMed id 12459518)^{3, 6} Chen R....Chan P. (2002)
Assignment of ferritin L gene (FTL) to human chromosome band 19q13.3 by in situ hybridization. (PubMed id 9526618)^{2, 3} Gasparini P....Zelante L. (1997)
Characterization of the human small-ribosomal-subunit proteins by N- terminal and internal sequencing, and mass spectrometry. (PubMed id 8706699)^{3, 4} Vladimirov S.N.... Otto A. (1996)
Structure and expression of ferritin genes in a human promyelocytic cell line that differentiates in vitro. (PubMed id 3023856)^{3, 4} Chou C.-C.... Salser W.A. (1986)
Cloning of the gene coding for human L apoferritin. (PubMed id 3754330)^{3, 4} Santoro C.... Silengo L. (1986)
Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones. (PubMed id 3840162)^{3, 4} Boyd D.... Drysdale J.W. (1985)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2512	HGNC: 3999	AceView: FTL	Ensembl:ENSG00000087086	euGenes: HUgn2512
ECgene: FTL	H-InvDB: FTL

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=FTL
Wikipedia	http://en.wikipedia.org/wiki/Ferritin

Licensable Technologies for FTL
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for FTL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for FTL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for FTL		Antibodies for FTL
	Explore super-pooled esiRNAs		Proteins for FTL
	Lentivirus-delivered shRNAs for FTL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FTL)
	Antibodies (FTL)
	Chimera RNAi (FTL)
	Custom Service for Mouse Mab
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Antibodies for FTL

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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FTL Gene at Home site.
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FTL Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for FTL

Summaries
for FTL

Genomic Location
for FTL

Proteins
for FTL

Protein Domains/
Families
for FTL

Gene Function
for FTL

Pathways & Interactions
for FTL

Drugs & Compounds
for FTL

Transcripts
for FTL

Expression
for FTL

Orthologs
for FTL

Paralogs
for FTL

SNPs/Variants
for FTL

Disorders & Mutations
for FTL

Medical News
for FTL

Publications
for FTL

Search for FTL

Genome Databases showing FTL

Other Databases showing FTL

Specialized Databases showing FTL

Licensable Technologies
for FTL

Services
for FTL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

FTL Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor FTL

Summariesfor FTL

Genomic Locationfor FTL

Proteinsfor FTL

Protein Domains/Familiesfor FTL

Gene Functionfor FTL

Pathways & Interactionsfor FTL

Drugs & Compoundsfor FTL

Transcriptsfor FTL

Expression for FTL

Orthologsfor FTL

Paralogsfor FTL

SNPs/Variantsfor FTL

Disorders & Mutationsfor FTL

Medical Newsfor FTL

Publicationsfor FTL

Search for FTL

Genome Databases showing FTL

Other Databases showing FTL

Specialized Databases showing FTL

Licensable Technologiesfor FTL

Servicesfor FTL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for FTL

Summaries
for FTL

Genomic Location
for FTL

Proteins
for FTL

Protein Domains/
Families
for FTL

Gene Function
for FTL

Pathways & Interactions
for FTL

Drugs & Compounds
for FTL

Transcripts
for FTL

Expression
for FTL

Orthologs
for FTL

Paralogs
for FTL

SNPs/Variants
for FTL

Disorders & Mutations
for FTL

Medical News
for FTL

Publications
for FTL

Licensable Technologies
for FTL

Services
for FTL