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Aliases for FTHL17 Gene

Aliases for FTHL17 Gene

  • Ferritin, Heavy Polypeptide-Like 17 2 3
  • Cancer/Testis Antigen 38 2 3 4
  • CT38 3 4

External Ids for FTHL17 Gene

Previous GeneCards Identifiers for FTHL17 Gene

  • GC0XM029592
  • GC0XM029774
  • GC0XM030291
  • GC0XM030451
  • GC0XM030452
  • GC0XM030849
  • GC0XM028830

Summaries for FTHL17 Gene

Entrez Gene Summary for FTHL17 Gene

  • This gene is orthologous to a mouse gene that encodes a ferritin heavy polypeptide-like protein and shows testis-specific expression. [provided by RefSeq, Oct 2009]

GeneCards Summary for FTHL17 Gene

FTHL17 (Ferritin, Heavy Polypeptide-Like 17) is a Protein Coding gene. GO annotations related to this gene include ferric iron binding. An important paralog of this gene is FTL.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTHL17 Gene

Genomics for FTHL17 Gene

Regulatory Elements for FTHL17 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for FTHL17 Gene

Chromosome:
X
Start:
31,071,241 bp from pter
End:
31,072,053 bp from pter
Size:
813 bases
Orientation:
Minus strand

Genomic View for FTHL17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for FTHL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTHL17 Gene

Proteins for FTHL17 Gene

  • Protein details for FTHL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXU8-FHL17_HUMAN
    Recommended name:
    Ferritin heavy polypeptide-like 17
    Protein Accession:
    Q9BXU8
    Secondary Accessions:
    • Q6NT24
    • Q6NTE2

    Protein attributes for FTHL17 Gene

    Size:
    183 amino acids
    Molecular mass:
    21142 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FTHL17 Gene

Proteomics data for FTHL17 Gene at MOPED

Post-translational modifications for FTHL17 Gene

No Post-translational modifications

Other Protein References for FTHL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FTHL17 Gene

Domains & Families for FTHL17 Gene

Suggested Antigen Peptide Sequences for FTHL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXU8

UniProtKB/Swiss-Prot:

FHL17_HUMAN :
  • Contains 1 ferritin-like diiron domain.
  • Belongs to the ferritin family.
Domain:
  • Contains 1 ferritin-like diiron domain.
Family:
  • Belongs to the ferritin family.
genes like me logo Genes that share domains with FTHL17: view

No data available for Gene Families for FTHL17 Gene

Function for FTHL17 Gene

Gene Ontology (GO) - Molecular Function for FTHL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008199 ferric iron binding IEA --
genes like me logo Genes that share ontologies with FTHL17: view
genes like me logo Genes that share phenotypes with FTHL17: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FTHL17

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTHL17 Gene

Localization for FTHL17 Gene

Gene Ontology (GO) - Cellular Components for FTHL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
genes like me logo Genes that share ontologies with FTHL17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for FTHL17 Gene

Pathways & Interactions for FTHL17 Gene

SuperPathways for FTHL17 Gene

No Data Available

Interacting Proteins for FTHL17 Gene

Gene Ontology (GO) - Biological Process for FTHL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006826 iron ion transport IEA --
GO:0006879 cellular iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with FTHL17: view

No data available for Pathways by source and SIGNOR curated interactions for FTHL17 Gene

Drugs & Compounds for FTHL17 Gene

No Compound Related Data Available

Transcripts for FTHL17 Gene

mRNA/cDNA for FTHL17 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for FTHL17

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTHL17 Gene

No ASD Table

Relevant External Links for FTHL17 Gene

GeneLoc Exon Structure for
FTHL17
ECgene alternative splicing isoforms for
FTHL17

Expression for FTHL17 Gene

mRNA expression in normal human tissues for FTHL17 Gene

mRNA differential expression in normal tissues according to GTEx for FTHL17 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for FTHL17 Gene

This gene is overexpressed in Tlymphocyte (53.1) and Brain (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FTHL17 Gene



SOURCE GeneReport for Unigene cluster for FTHL17 Gene Hs.333125

mRNA Expression by UniProt/SwissProt for FTHL17 Gene

Q9BXU8-FHL17_HUMAN
Tissue specificity: Testis specific. Also expressed in several cancers.
genes like me logo Genes that share expression patterns with FTHL17: view

Protein tissue co-expression partners for FTHL17 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FTHL17 Gene

Orthologs for FTHL17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FTHL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTHL17 35
  • 98.72 (n)
  • 96.17 (a)
FTHL17 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Fthl17 16
1600014K23Rik 36
  • 48 (a)
OneToMany
Fthl17 36
  • 54 (a)
OneToMany
Gm14458 36
  • 54 (a)
OneToMany
Gm14511 36
  • 56 (a)
OneToMany
Gm5634 36
  • 56 (a)
OneToMany
Gm5635 36
  • 56 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 55 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
ManyToMany
-- 36
  • 57 (a)
ManyToMany
-- 36
  • 63 (a)
ManyToMany
-- 36
  • 36 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves FTH 36
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fth1a 36
  • 55 (a)
ManyToMany
fth1b 36
  • 55 (a)
ManyToMany
Species with no ortholog for FTHL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FTHL17 Gene

ENSEMBL:
Gene Tree for FTHL17 (if available)
TreeFam:
Gene Tree for FTHL17 (if available)

Paralogs for FTHL17 Gene

Paralogs for FTHL17 Gene

(5) SIMAP similar genes for FTHL17 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FTHL17 Gene

genes like me logo Genes that share paralogs with FTHL17: view

Variants for FTHL17 Gene

Sequence variations from dbSNP and Humsavar for FTHL17 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs375355 -- 31,070,776(+) AAAGA(A/G)GTACC downstream-variant-500B
rs377515 -- 31,073,951(-) accca(A/G)aatag upstream-variant-2KB
rs396951 -- 31,073,935(+) gcaga(A/G/T)attgc upstream-variant-2KB
rs397055 -- 31,073,858(-) gccag(G/T)gttgt upstream-variant-2KB
rs412823 -- 31,072,328(+) cagga(C/G)atgga upstream-variant-2KB

Variation tolerance for FTHL17 Gene

Residual Variation Intolerance Score: 85.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FTHL17 Gene

HapMap Linkage Disequilibrium report
FTHL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FTHL17 Gene

Disorders for FTHL17 Gene

Relevant External Links for FTHL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FTHL17
genes like me logo Genes that share disorders with FTHL17: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTHL17 Gene

Publications for FTHL17 Gene

  1. The Ferritin-Heavy-Polypeptide-Like-17 (FTHL17) gene encodes a ferritin with low stability and no ferroxidase activity and with a partial nuclear localization. (PMID: 25749565) Ruzzenenti P. … Poli M. (Biochim. Biophys. Acta 2015) 67
  2. Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome. (PMID: 19812237) Poplinski A. … Gromoll J. (Eur. J. Endocrinol. 2010) 67
  3. Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. (PMID: 16929165) Atanackovic D. … Leuwer R. (Cancer Biol. Ther. 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PMID: 12704671) Loriot A. … De Smet C. (Int. J. Cancer 2003) 67

Products for FTHL17 Gene

Sources for FTHL17 Gene

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