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Aliases for FTHL17 Gene

Aliases for FTHL17 Gene

  • Ferritin Heavy Chain Like 17 2 3 5
  • Cancer/Testis Antigen 38 2 3 4
  • Ferritin, Heavy Polypeptide-Like 17 2 3
  • CT38 3 4
  • Ferritin Heavy Polypeptide-Like 17 3

External Ids for FTHL17 Gene

Previous GeneCards Identifiers for FTHL17 Gene

  • GC0XM029592
  • GC0XM029774
  • GC0XM030291
  • GC0XM030451
  • GC0XM030452
  • GC0XM030849
  • GC0XM028830

Summaries for FTHL17 Gene

Entrez Gene Summary for FTHL17 Gene

  • This gene encodes a ferritin heavy chain-like protein. This gene is primarily expressed in embryonic germ cells. The encoded protein may lack ferroxidase activity. Multiple pseudogenes of this gene are found on chromosome X. [provided by RefSeq, Oct 2016]

GeneCards Summary for FTHL17 Gene

FTHL17 (Ferritin Heavy Chain Like 17) is a Protein Coding gene. GO annotations related to this gene include ferric iron binding. An important paralog of this gene is FTH1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTHL17 Gene

Genomics for FTHL17 Gene

Regulatory Elements for FTHL17 Gene

Enhancers for FTHL17 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF031038 0.4 ENCODE 13.6 +33.2 33160 0.8 CTCF PKNOX1 MAZ ZNF654 MAFG TRIM22 REST RAD21 ZNF316 NBN FTHL17 GC0XP031068 GC0XM030974
GH0XF031135 0.9 Ensembl ENCODE 12.7 -64.3 -64280 1.1 PKNOX1 TBL1XR1 BMI1 RELA CBX5 CREM CHD2 MAZ MTA2 ZBED1 FTHL17 TAB3 GC0XM031207
GH0XF031125 0.2 ENCODE 12.6 -54.2 -54209 1.1 PKNOX1 TRIM28 FTHL17 GC0XM031207
GH0XF031021 0.8 ENCODE 12.5 +50.3 50315 0.2 SMARCA4 FTHL17 GC0XM030974 GC0XP031068
GH0XF031190 0.4 ENCODE 12.4 -118.7 -118653 0.8 PKNOX1 HLF ZEB2 ZBTB8A ZNF24 PRDM10 ZNF843 WT1 TRIM28 FTHL17 GC0XM031207
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around FTHL17 on UCSC Golden Path with GeneCards custom track

Genomic Location for FTHL17 Gene

Chromosome:
X
Start:
31,071,241 bp from pter
End:
31,072,053 bp from pter
Size:
813 bases
Orientation:
Minus strand

Genomic View for FTHL17 Gene

Genes around FTHL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTHL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTHL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTHL17 Gene

Proteins for FTHL17 Gene

  • Protein details for FTHL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXU8-FHL17_HUMAN
    Recommended name:
    Ferritin heavy polypeptide-like 17
    Protein Accession:
    Q9BXU8
    Secondary Accessions:
    • Q6NT24
    • Q6NTE2

    Protein attributes for FTHL17 Gene

    Size:
    183 amino acids
    Molecular mass:
    21142 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FTHL17 Gene

Post-translational modifications for FTHL17 Gene

No Post-translational modifications

Other Protein References for FTHL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FTHL17 Gene

Domains & Families for FTHL17 Gene

Suggested Antigen Peptide Sequences for FTHL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BXU8

UniProtKB/Swiss-Prot:

FHL17_HUMAN :
  • Contains 1 ferritin-like diiron domain.
  • Belongs to the ferritin family.
Domain:
  • Contains 1 ferritin-like diiron domain.
Family:
  • Belongs to the ferritin family.
genes like me logo Genes that share domains with FTHL17: view

No data available for Gene Families for FTHL17 Gene

Function for FTHL17 Gene

Gene Ontology (GO) - Molecular Function for FTHL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding IBA --
GO:0008199 ferric iron binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FTHL17: view
genes like me logo Genes that share phenotypes with FTHL17: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTHL17 Gene

Localization for FTHL17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for FTHL17 Gene COMPARTMENTS Subcellular localization image for FTHL17 gene
Compartment Confidence
cytosol 2
extracellular 2

Gene Ontology (GO) - Cellular Components for FTHL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with FTHL17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FTHL17 Gene

Pathways & Interactions for FTHL17 Gene

SuperPathways for FTHL17 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FTHL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006826 iron ion transport IEA --
GO:0006879 cellular iron ion homeostasis IEA --
GO:0006880 intracellular sequestering of iron ion IBA --
genes like me logo Genes that share ontologies with FTHL17: view

No data available for Pathways by source and SIGNOR curated interactions for FTHL17 Gene

Transcripts for FTHL17 Gene

mRNA/cDNA for FTHL17 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for FTHL17 Gene

No ASD Table

Relevant External Links for FTHL17 Gene

GeneLoc Exon Structure for
FTHL17
ECgene alternative splicing isoforms for
FTHL17

Expression for FTHL17 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FTHL17 Gene

mRNA differential expression in normal tissues according to GTEx for FTHL17 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for FTHL17 Gene

This gene is overexpressed in Tlymphocyte (53.1) and Brain (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FTHL17 Gene



Protein tissue co-expression partners for FTHL17 Gene

NURSA nuclear receptor signaling pathways regulating expression of FTHL17 Gene:

FTHL17

SOURCE GeneReport for Unigene cluster for FTHL17 Gene:

Hs.333125

mRNA Expression by UniProt/SwissProt for FTHL17 Gene:

Q9BXU8-FHL17_HUMAN
Tissue specificity: Testis specific. Also expressed in several cancers.
genes like me logo Genes that share expression patterns with FTHL17: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FTHL17 Gene

Orthologs for FTHL17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FTHL17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FTHL17 34 35
  • 98.72 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 63 (a)
ManyToMany
-- 35
  • 57 (a)
ManyToMany
-- 35
  • 36 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia -- 35
  • 58 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 55 (a)
OneToMany
-- 35
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm14511 35
  • 56 (a)
OneToMany
Gm5634 35
  • 56 (a)
OneToMany
Gm5635 35
  • 56 (a)
OneToMany
Fthl17 35
  • 54 (a)
OneToMany
Gm14458 35
  • 54 (a)
OneToMany
1600014K23Rik 35
  • 48 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 51 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves FTH 35
  • 63 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii fth1a 35
  • 55 (a)
ManyToMany
fth1b 35
  • 55 (a)
ManyToMany
Species where no ortholog for FTHL17 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FTHL17 Gene

ENSEMBL:
Gene Tree for FTHL17 (if available)
TreeFam:
Gene Tree for FTHL17 (if available)

Paralogs for FTHL17 Gene

Paralogs for FTHL17 Gene

(5) SIMAP similar genes for FTHL17 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for FTHL17 Gene

genes like me logo Genes that share paralogs with FTHL17: view

Variants for FTHL17 Gene

Sequence variations from dbSNP and Humsavar for FTHL17 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1092636 -- 31,073,837(+) tgtgt(C/T)taaac upstream-variant-2KB
rs111658115 -- 31,071,049(+) CATAC(C/G)CTGGT downstream-variant-500B
rs111834423 -- 31,072,362(+) AACCC(C/T)GTCTC upstream-variant-2KB
rs112525239 -- 31,071,981(+) GAGCA(A/C)ACGGG utr-variant-5-prime
rs113057142 -- 31,070,804(+) AGAGC(C/T)CCCAC downstream-variant-500B

Variation tolerance for FTHL17 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FTHL17 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FTHL17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FTHL17 Gene

Disorders for FTHL17 Gene

Relevant External Links for FTHL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FTHL17

No disorders were found for FTHL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTHL17 Gene

Publications for FTHL17 Gene

  1. The Ferritin-Heavy-Polypeptide-Like-17 (FTHL17) gene encodes a ferritin with low stability and no ferroxidase activity and with a partial nuclear localization. (PMID: 25749565) Ruzzenenti P. … Poli M. (Biochim. Biophys. Acta 2015) 2 3 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PMID: 12704671) Loriot A. … De Smet C. (Int. J. Cancer 2003) 3 4 64
  4. An abundance of X-linked genes expressed in spermatogonia. (PMID: 11279525) Wang P.J. … Page D.C. (Nat. Genet. 2001) 3 4 64
  5. Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome. (PMID: 19812237) Poplinski A. … Gromoll J. (Eur. J. Endocrinol. 2010) 3 64

Products for FTHL17 Gene

Sources for FTHL17 Gene

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