FTHL17 Gene
protein-coding GIFtS: 45
GCID: GC0XM030999
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ferritin, heavy polypeptide-like 17
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Aliases
for FTHL17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Ferritin, Heavy Polypeptide-Like 171 2 | | CT381 2 3 | | Cancer/Testis Antigen 382 3 | | Ferritin Heavy Polypeptide-Like 172 |
Export aliases for FTHL17 gene to outside databasesPrevious GC identifers: GC0XM029592 GC0XM029774 GC0XM030291 GC0XM030451 GC0XM030452 GC0XM030849 GC0XM028830 |
Summaries
for FTHL17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for FTHL17:
This gene is orthologous to a mouse gene that encodes a ferritin heavy polypeptide-like protein and showstestis-specific expression. (provided by RefSeq, Oct 2009)
|
Genomic Views
for FTHL17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167197.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the FTHL17 gene promoter:
Nkx3-1 Nkx3-1 v4 AML1a AP-1 MIF-1 Nkx3-1 v1 MEF-2A Nkx3-1 v2 Nkx3-1 v3 aMEF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for FTHL17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat FTHL17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xp21 Ensembl cytogenetic band: Xp21.2 HGNC cytogenetic band: Xp21.2FTHL17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XM030999: view genomic region
(about GC identifiers)
Start:
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31,089,358 bp from pter |
End:
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31,090,170 bp from pter |
Size:
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813 bases |
Orientation:
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minus strand |
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Proteins
for FTHL17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FHL17_HUMAN, Q9BXU8 (See
protein sequence)Recommended Name: Ferritin heavy polypeptide-like 17 Size: 183 amino acids; 21142 Da
Secondary accessions: Q6NT24 Q6NTE2Explore the universe of human proteins at neXtProt for FTHL17: NX_Q9BXU8
FTHL17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114100.1
ENSEMBL proteins: ENSP00000368207
Human Recombinant Protein Products:
FTHL17 Antibody Products:
Assay Products for FTHL17: |
Protein
Domains /
Families
for FTHL17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
FTHL17 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9BXU8ProtoNet protein and cluster: Q9BXU8 3 Blocks protein families: IPB001519 Ferritin IPB008331 Ferritin and Dps IPB014034 Ferritin
UniProtKB/Swiss-Prot: FHL17_HUMAN, Q9BXU8Similarity: Belongs to the ferritin familySimilarity: Contains 1 ferritin-like diiron domain |
Function
for FTHL17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTHL17 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTHL17
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008199 | ferric iron binding |
IEA | -- | | GO:0016491 | oxidoreductase activity |
IEA | -- |
FTHL17 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for FTHL17:
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Pathways & Interactions
for FTHL17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for FTHL17
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for FTHL17 (ENSP000003682074) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006826 | iron ion transport |
IEA | -- | | GO:0006879 | cellular iron ion homeostasis |
IEA | -- |
FTHL17 for ontologies About GeneDecksing
|
Drugs & Compounds
for FTHL17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for FTHL17
Search CenterWatch for drugs/clinical trials and news about FTHL17 / FHL17
|
Transcripts
for FTHL17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for FTHL17 gene: NM_031894.2 Unigene Cluster for FTHL17: Ferritin, heavy polypeptide-like 17 Hs.333125 Unigene Representative Sequence: AF2855921 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000359202(uc004dcl.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for FTHL17 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for FTHL17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: FTHL17 (NM_031894) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for FTHL17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat FTHL17 |
Additional cDNA sequence: AF285592.1 BC069069.1 BC069538.1 BC100768.1 BC100769.1 BC100770.1 1 DOTS entry: DT.102819930 4 AceView cDNA sequences: BC069538 BC069069 NM_031894 AF285592
GeneLoc Exon Structure
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Expression
for FTHL17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| FTHL17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGCCCTTTC
About this image
See FTHL17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for FTHL17
SOURCE GeneReport for Unigene cluster: Hs.333125
UniProtKB/Swiss-Prot: FHL17_HUMAN, Q9BXU8Tissue specificity: Testis specific. Also expressed in several cancers
SABiosciences Custom PCR Arrays for FTHL17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for FTHL17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat FTHL17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat FTHL17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat FTHL17 |
Orthologs
for FTHL17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for FTHL17 gene from 8/20 species (see all 20) About this table
ENSEMBL Gene Tree for FTHL17 (if available)
TreeFam Gene Tree for FTHL17 (if available) |
Paralogs
for FTHL17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for FTHL17 gene
- FTMT2 FTH12 FTL2
5 SIMAP similar genes for FTHL17 using alignment to 1 protein entry: FHL17_HUMAN:FTH1P19 FTH1 FTMT FTL FTL variant
FTHL17 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for FTHL17
PGOHUM00000241235
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Genomic Variants
for FTHL17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for FTHL17 (31089358 - 31090170 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for FTHL17
1 CNV: 3265
Human Gene Mutation Database (HGMD): FTHL17
Locus Specific Mutation Databases (LSDB): FTHL17
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing FTHL17 |
|
Disorders
/ Diseases
for FTHL17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
FTHL17 for disorders About GeneDecksing
OMIM gene information: 300308
OMIM disorders: --
3  diseases for FTHL17: About MalaCardsklinefelter's syndrome squamous cell carcinoma carcinoma
Export disorders for FTHL17 gene to outside databases
|
Publications
for FTHL17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for FTHL17 gene integrated from 9 sources:
(articles sorted by number of sources associating them with FTHL17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An abundance of X-linked genes expressed in spermatogonia. (PubMed id 11279525)1, 2, 3 Wang P.J.... Page D.C. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PubMed id 12704671)1, 2 Loriot A.... De Smet C. (2003)
- Severe XIST hypomethylation clearly distinguishes (SR Y+) 46,XX-maleness from Klinefelter syndrome. (PubMed id 19812237)1 Poplinski A....Gromoll J. (2010)
- Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. (PubMed id 16929165)1 Atanackovic D....Leuwer R. (2006)
- Molecular and cytogenetic characterization of two azoospermic patients with X-autosome translocation. (PubMed id 14531651)1 Lee S....Cha K.Y. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for FTHL17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing FTHL17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing FTHL17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing FTHL17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for FTHL17 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for FTHL17 gene:
Search GeneIP for patents involving FTHL17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for FTHL17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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