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Aliases for FTHL17 Gene

Aliases for FTHL17 Gene

  • Ferritin, Heavy Polypeptide-Like 17 2 3 5
  • Cancer/Testis Antigen 38 2 3 4
  • CT38 3 4

External Ids for FTHL17 Gene

Previous GeneCards Identifiers for FTHL17 Gene

  • GC0XM029592
  • GC0XM029774
  • GC0XM030291
  • GC0XM030451
  • GC0XM030452
  • GC0XM030849
  • GC0XM028830

Summaries for FTHL17 Gene

Entrez Gene Summary for FTHL17 Gene

  • This gene encodes a ferritin heavy chain-like protein. This gene is primarily expressed in embryonic germ cells. The encoded protein may lack ferroxidase activity. Multiple pseudogenes of this gene are found on chromosomes X. [provided by RefSeq, Jan 2016]

GeneCards Summary for FTHL17 Gene

FTHL17 (Ferritin, Heavy Polypeptide-Like 17) is a Protein Coding gene. GO annotations related to this gene include ferric iron binding. An important paralog of this gene is FTL.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTHL17 Gene

Genomics for FTHL17 Gene

Regulatory Elements for FTHL17 Gene

Enhancers for FTHL17 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around FTHL17 on UCSC Golden Path with GeneCards custom track

Genomic Location for FTHL17 Gene

31,071,241 bp from pter
31,072,053 bp from pter
813 bases
Minus strand

Genomic View for FTHL17 Gene

Genes around FTHL17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTHL17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTHL17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTHL17 Gene

Proteins for FTHL17 Gene

  • Protein details for FTHL17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ferritin heavy polypeptide-like 17
    Protein Accession:
    Secondary Accessions:
    • Q6NT24
    • Q6NTE2

    Protein attributes for FTHL17 Gene

    183 amino acids
    Molecular mass:
    21142 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FTHL17 Gene

Proteomics data for FTHL17 Gene at MOPED

Post-translational modifications for FTHL17 Gene

No Post-translational modifications

Other Protein References for FTHL17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FTHL17 Gene

Domains & Families for FTHL17 Gene

Suggested Antigen Peptide Sequences for FTHL17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ferritin-like diiron domain.
  • Belongs to the ferritin family.
  • Contains 1 ferritin-like diiron domain.
  • Belongs to the ferritin family.
genes like me logo Genes that share domains with FTHL17: view

No data available for Gene Families for FTHL17 Gene

Function for FTHL17 Gene

genes like me logo Genes that share phenotypes with FTHL17: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTHL17 Gene

Localization for FTHL17 Gene

Subcellular locations from

Jensen Localization Image for FTHL17 Gene COMPARTMENTS Subcellular localization image for FTHL17 gene
Compartment Confidence
cytosol 2
extracellular 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for FTHL17 Gene

Pathways & Interactions for FTHL17 Gene

SuperPathways for FTHL17 Gene

No Data Available

Interacting Proteins for FTHL17 Gene

Gene Ontology (GO) - Biological Process for FTHL17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006879 cellular iron ion homeostasis IEA --
genes like me logo Genes that share ontologies with FTHL17: view

No data available for Pathways by source and SIGNOR curated interactions for FTHL17 Gene

Drugs & Compounds for FTHL17 Gene

No Compound Related Data Available

Transcripts for FTHL17 Gene

mRNA/cDNA for FTHL17 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FTHL17 Gene

No ASD Table

Relevant External Links for FTHL17 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FTHL17 Gene

mRNA expression in normal human tissues for FTHL17 Gene

mRNA differential expression in normal tissues according to GTEx for FTHL17 Gene

This gene is overexpressed in Testis (x51.7).

Protein differential expression in normal tissues from HIPED for FTHL17 Gene

This gene is overexpressed in Tlymphocyte (53.1) and Brain (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for FTHL17 Gene

SOURCE GeneReport for Unigene cluster for FTHL17 Gene Hs.333125

mRNA Expression by UniProt/SwissProt for FTHL17 Gene

Tissue specificity: Testis specific. Also expressed in several cancers.
genes like me logo Genes that share expression patterns with FTHL17: view

Protein tissue co-expression partners for FTHL17 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for FTHL17 Gene

Orthologs for FTHL17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FTHL17 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FTHL17 35
  • 98.72 (n)
  • 96.17 (a)
FTHL17 36
  • 96 (a)
(Bos Taurus)
Mammalia -- 36
  • 51 (a)
-- 36
  • 58 (a)
-- 36
  • 55 (a)
-- 36
  • 55 (a)
-- 36
  • 56 (a)
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
-- 36
  • 42 (a)
-- 36
  • 50 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 30 (a)
-- 36
  • 57 (a)
-- 36
  • 63 (a)
-- 36
  • 36 (a)
(Mus musculus)
Mammalia 1600014K23Rik 36
  • 48 (a)
Fthl17 36
  • 54 (a)
Gm14458 36
  • 54 (a)
Gm14511 36
  • 56 (a)
Gm5634 36
  • 56 (a)
Gm5635 36
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 47 (a)
(Gallus gallus)
Aves FTH 36
  • 63 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
(Danio rerio)
Actinopterygii fth1a 36
  • 55 (a)
fth1b 36
  • 55 (a)
Species with no ortholog for FTHL17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FTHL17 Gene

Gene Tree for FTHL17 (if available)
Gene Tree for FTHL17 (if available)

Paralogs for FTHL17 Gene

Paralogs for FTHL17 Gene

(5) SIMAP similar genes for FTHL17 Gene using alignment to 1 proteins: Pseudogenes for FTHL17 Gene

genes like me logo Genes that share paralogs with FTHL17: view

Variants for FTHL17 Gene

Sequence variations from dbSNP and Humsavar for FTHL17 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs16989319 - 31,071,594(+) GCCAG(C/G)TGGTA reference, missense
rs17340519 - 31,071,542(+) CAGGT(A/G)GTGGC reference, missense
rs747689610 -- 31,071,043(+) ACCCC(A/C)CATAC downstream-variant-500B
rs747986840 -- 31,071,464(+) GCCGG(C/T)TTCCG reference, missense
rs748155661 -- 31,071,587(+) CTCCA(A/C)GGCCA reference, missense

Variation tolerance for FTHL17 Gene

Residual Variation Intolerance Score: 85.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.22; 76.14% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for FTHL17 Gene

Disorders for FTHL17 Gene

Relevant External Links for FTHL17

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for FTHL17 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTHL17 Gene

Publications for FTHL17 Gene

  1. The Ferritin-Heavy-Polypeptide-Like-17 (FTHL17) gene encodes a ferritin with low stability and no ferroxidase activity and with a partial nuclear localization. (PMID: 25749565) Ruzzenenti P. … Poli M. (Biochim. Biophys. Acta 2015) 2 3 67
  2. Severe XIST hypomethylation clearly distinguishes (SRY+) 46,XX-maleness from Klinefelter syndrome. (PMID: 19812237) Poplinski A. … Gromoll J. (Eur. J. Endocrinol. 2010) 3
  3. Expression of cancer-testis antigens as possible targets for antigen-specific immunotherapy in head and neck squamous cell carcinoma. (PMID: 16929165) Atanackovic D. … Leuwer R. (Cancer Biol. Ther. 2006) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. Five new human cancer-germline genes identified among 12 genes expressed in spermatogonia. (PMID: 12704671) Loriot A. … De Smet C. (Int. J. Cancer 2003) 3

Products for FTHL17 Gene

Sources for FTHL17 Gene