Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FTCDNL1 Gene

Aliases for FTCDNL1 Gene

  • Formiminotransferase Cyclodeaminase N-Terminal Like 2 3 5
  • Formiminotransferase-Cyclodeaminase N-Terminal-Like Protein 3 4
  • FONG 3 4
  • Formiminotransferase N-Terminal Subdomain-Containing Protein 3
  • Formiminotransferase N-Terminal Sub-Domain Containing Gene 2
  • Formiminotransferase N-Terminal Sub-Domain Containing 3

External Ids for FTCDNL1 Gene

Previous GeneCards Identifiers for FTCDNL1 Gene

  • GC02M200628

Summaries for FTCDNL1 Gene

GeneCards Summary for FTCDNL1 Gene

FTCDNL1 (Formiminotransferase Cyclodeaminase N-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include transferase activity and folic acid binding. An important paralog of this gene is FTCD.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTCDNL1 Gene

Genomics for FTCDNL1 Gene

Regulatory Elements for FTCDNL1 Gene

Enhancers for FTCDNL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G199737 1.2 Ensembl ENCODE 29.1 +112.2 112210 2.5 PKNOX1 FOXA2 ZFP64 ARID4B ZNF48 YY1 SLC30A9 ZNF143 FOS NFYC FTCDNL1 SATB2 PIR44514 SEPHS1P6
GH02G200402 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -555.4 -555360 8.2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 YBX1 YY1 ZNF207 SPATS2L PPIL3 KCTD18 FTCDNL1 AOX3P CLK1 BZW1 RNY4P34 LOC101927741
GH02G199798 0.4 ENCODE 18.5 +51.9 51912 1.6 RFX1 CTBP1 FTCDNL1 PIR44514
GH02G200396 1.6 FANTOM5 Ensembl ENCODE dbSUPER 4.6 -547.1 -547140 4.2 CTCF ZNF146 FOXA2 PKNOX1 JUN EBF1 ZNF316 GATA2 ZNF600 FOS SPATS2L FTCDNL1 AOX3P RNY4P34 LOC101927741
GH02G199910 1.1 ENCODE 4.6 -60.4 -60418 2.8 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 LOC101927687 FTCDNL1 C2orf69 MAIP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around FTCDNL1 on UCSC Golden Path with GeneCards custom track

Promoters for FTCDNL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000128598 73 1400 ARID4B SIN3A FEZF1 DMAP1 BRCA1 ZNF2 ZNF48 GLIS2 GATA2 ZNF143

Genomic Location for FTCDNL1 Gene

Chromosome:
2
Start:
199,760,536 bp from pter
End:
199,851,173 bp from pter
Size:
90,638 bases
Orientation:
Minus strand

Genomic View for FTCDNL1 Gene

Genes around FTCDNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTCDNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTCDNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTCDNL1 Gene

Proteins for FTCDNL1 Gene

  • Protein details for FTCDNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E5RQL4-FONG_HUMAN
    Recommended name:
    Formiminotransferase N-terminal subdomain-containing protein
    Protein Accession:
    E5RQL4

    Protein attributes for FTCDNL1 Gene

    Size:
    147 amino acids
    Molecular mass:
    16268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FTCDNL1 Gene

Post-translational modifications for FTCDNL1 Gene

No Post-translational modifications

Other Protein References for FTCDNL1 Gene

No data available for DME Specific Peptides for FTCDNL1 Gene

Domains & Families for FTCDNL1 Gene

Protein Domains for FTCDNL1 Gene

Suggested Antigen Peptide Sequences for FTCDNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

E5RQL4

UniProtKB/Swiss-Prot:

FONG_HUMAN :
  • Belongs to the formiminotransferase family.
Family:
  • Belongs to the formiminotransferase family.
genes like me logo Genes that share domains with FTCDNL1: view

No data available for Gene Families for FTCDNL1 Gene

Function for FTCDNL1 Gene

Gene Ontology (GO) - Molecular Function for FTCDNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005542 folic acid binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with FTCDNL1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTCDNL1 Gene

Localization for FTCDNL1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FTCDNL1 Gene

Pathways & Interactions for FTCDNL1 Gene

SuperPathways for FTCDNL1 Gene

No Data Available

Interacting Proteins for FTCDNL1 Gene

Gene Ontology (GO) - Biological Process for FTCDNL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with FTCDNL1: view

No data available for Pathways by source and SIGNOR curated interactions for FTCDNL1 Gene

Transcripts for FTCDNL1 Gene

mRNA/cDNA for FTCDNL1 Gene

(3) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FTCDNL1 Gene

No ASD Table

Relevant External Links for FTCDNL1 Gene

GeneLoc Exon Structure for
FTCDNL1
ECgene alternative splicing isoforms for
FTCDNL1

Expression for FTCDNL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FTCDNL1 Gene

mRNA differential expression in normal tissues according to GTEx for FTCDNL1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of FTCDNL1 Gene:

FTCDNL1

mRNA Expression by UniProt/SwissProt for FTCDNL1 Gene:

E5RQL4-FONG_HUMAN
Tissue specificity: Widely expressed with highest levels in liver and skeletal muscle, and moderate levels in kidney, bone and pancreas.
genes like me logo Genes that share expression patterns with FTCDNL1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FTCDNL1 Gene

Orthologs for FTCDNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FTCDNL1 Gene

Organism Taxonomy Gene Similarity Type Details
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 33 (a)
OneToMany
-- 35
  • 23 (a)
OneToMany
cow
(Bos Taurus)
Mammalia FTCDNL1 35
  • 30 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 6 (a)
OneToMany
chicken
(Gallus gallus)
Aves FTCD 35
  • 6 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia FTCDNL1 35
  • 23 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FTCDNL1 35
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 6 (a)
OneToMany
Species where no ortholog for FTCDNL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FTCDNL1 Gene

ENSEMBL:
Gene Tree for FTCDNL1 (if available)
TreeFam:
Gene Tree for FTCDNL1 (if available)

Paralogs for FTCDNL1 Gene

Paralogs for FTCDNL1 Gene

genes like me logo Genes that share paralogs with FTCDNL1: view

Variants for FTCDNL1 Gene

Sequence variations from dbSNP and Humsavar for FTCDNL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000045361 -- 199,791,667(+) TTGTA(C/T)ATAAT intron-variant
rs1000045755 -- 199,839,947(+) CGACA(C/G)CATAA intron-variant
rs1000096588 -- 199,797,389(+) TCTTA(A/G)TTCTT intron-variant
rs1000148996 -- 199,796,967(+) CTCCT(C/T)TGCAG intron-variant
rs1000183602 -- 199,850,492(+) GATGG(C/T)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for FTCDNL1 Gene

Variant ID Type Subtype PubMed ID
esv3593949 CNV loss 21293372

Variation tolerance for FTCDNL1 Gene

Gene Damage Index Score: 1.75; 33.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FTCDNL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FTCDNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FTCDNL1 Gene

Disorders for FTCDNL1 Gene

Relevant External Links for FTCDNL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FTCDNL1

No disorders were found for FTCDNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTCDNL1 Gene

Publications for FTCDNL1 Gene

  1. Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese. (PMID: 21573128) Kou I. … Ikegawa S. (PLoS ONE 2011) 2 3 4 64
  2. Association Study between the FTCDNL1 (FONG) and Susceptibility to Osteoporosis. (PMID: 26492493) Lu H.F. … Chang W.C. (PLoS ONE 2015) 3 64
  3. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3 64
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3 64
  5. Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases. (PMID: 23303384) Zhou H. … Ito H. (J. Hum. Genet. 2013) 3 64

Products for FTCDNL1 Gene

Sources for FTCDNL1 Gene

Content
Loading form....