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Aliases for FTCDNL1 Gene

Subcategory (RNA class) for FTCDNL1 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for FTCDNL1 Gene

  • Formiminotransferase Cyclodeaminase N-Terminal Like 2 3 5
  • FONG 3 4
  • Formiminotransferase-Cyclodeaminase N-Terminal-Like Protein 4
  • Formiminotransferase N-Terminal Sub-Domain Containing Gene 2
  • Formiminotransferase N-Terminal Sub-Domain Containing 3

External Ids for FTCDNL1 Gene

Previous GeneCards Identifiers for FTCDNL1 Gene

  • GC02M200628

Summaries for FTCDNL1 Gene

GeneCards Summary for FTCDNL1 Gene

FTCDNL1 (Formiminotransferase Cyclodeaminase N-Terminal Like) is an RNA Gene, and is affiliated with the ncRNA class. GO annotations related to this gene include transferase activity and folic acid binding. An important paralog of this gene is FTCD.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FTCDNL1 Gene

Genomics for FTCDNL1 Gene

Regulatory Elements for FTCDNL1 Gene

Promoters for FTCDNL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around FTCDNL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for FTCDNL1 Gene

Chromosome:
2
Start:
199,760,536 bp from pter
End:
199,851,173 bp from pter
Size:
90,638 bases
Orientation:
Minus strand

Genomic View for FTCDNL1 Gene

Genes around FTCDNL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FTCDNL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FTCDNL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FTCDNL1 Gene

Proteins for FTCDNL1 Gene

  • Protein details for FTCDNL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    E5RQL4-FONG_HUMAN
    Recommended name:
    Formiminotransferase N-terminal subdomain-containing protein
    Protein Accession:
    E5RQL4

    Protein attributes for FTCDNL1 Gene

    Size:
    147 amino acids
    Molecular mass:
    16268 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FTCDNL1 Gene

Proteomics data for FTCDNL1 Gene at MOPED

Post-translational modifications for FTCDNL1 Gene

No Post-translational modifications

Other Protein References for FTCDNL1 Gene

No data available for DME Specific Peptides for FTCDNL1 Gene

Domains & Families for FTCDNL1 Gene

Protein Domains for FTCDNL1 Gene

Suggested Antigen Peptide Sequences for FTCDNL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

E5RQL4

UniProtKB/Swiss-Prot:

FONG_HUMAN :
  • Belongs to the formiminotransferase family.
Family:
  • Belongs to the formiminotransferase family.
genes like me logo Genes that share domains with FTCDNL1: view

No data available for Gene Families for FTCDNL1 Gene

Function for FTCDNL1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FTCDNL1 Gene

Localization for FTCDNL1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for FTCDNL1 Gene

Pathways & Interactions for FTCDNL1 Gene

SuperPathways for FTCDNL1 Gene

No Data Available

Interacting Proteins for FTCDNL1 Gene

Gene Ontology (GO) - Biological Process for FTCDNL1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FTCDNL1 Gene

Drugs & Compounds for FTCDNL1 Gene

No Compound Related Data Available

Transcripts for FTCDNL1 Gene

mRNA/cDNA for FTCDNL1 Gene

(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FTCDNL1 Gene

No ASD Table

Relevant External Links for FTCDNL1 Gene

GeneLoc Exon Structure for
FTCDNL1
ECgene alternative splicing isoforms for
FTCDNL1

Expression for FTCDNL1 Gene

mRNA expression in normal human tissues for FTCDNL1 Gene

mRNA differential expression in normal tissues according to GTEx for FTCDNL1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.3).

mRNA Expression by UniProt/SwissProt for FTCDNL1 Gene

E5RQL4-FONG_HUMAN
Tissue specificity: Widely expressed with highest levels in liver and skeletal muscle, and moderate levels in kidney, bone and pancreas.
genes like me logo Genes that share expression patterns with FTCDNL1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for FTCDNL1 Gene

Orthologs for FTCDNL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FTCDNL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia FTCDNL1 36
  • 30 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
OneToMany
-- 36
  • 33 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 6 (a)
OneToMany
chicken
(Gallus gallus)
Aves FTCD 36
  • 6 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia FTCDNL1 36
  • 23 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii FTCDNL1 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 6 (a)
OneToMany
Species with no ortholog for FTCDNL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FTCDNL1 Gene

ENSEMBL:
Gene Tree for FTCDNL1 (if available)
TreeFam:
Gene Tree for FTCDNL1 (if available)

Paralogs for FTCDNL1 Gene

Paralogs for FTCDNL1 Gene

genes like me logo Genes that share paralogs with FTCDNL1: view

Variants for FTCDNL1 Gene

Sequence variations from dbSNP and Humsavar for FTCDNL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs717915 -- 199,850,043(+) GCTCT(C/T)CCTCA intron-variant
rs796363 -- 199,828,945(+) AACCA(C/T)GGGAT intron-variant
rs796364 -- 199,851,396(+) ATTGG(A/C)ATCTA upstream-variant-2KB
rs797163 -- 199,831,664(+) TTGGG(A/G)CATGC intron-variant
rs769954 -- 199,827,436(+) ATAAA(C/G)AGATA intron-variant

Variation tolerance for FTCDNL1 Gene

Gene Damage Index Score: 1.75; 33.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for FTCDNL1 Gene

HapMap Linkage Disequilibrium report
FTCDNL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for FTCDNL1 Gene

Disorders for FTCDNL1 Gene

Relevant External Links for FTCDNL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
FTCDNL1

No disorders were found for FTCDNL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FTCDNL1 Gene

Publications for FTCDNL1 Gene

  1. Common variants in a novel gene, FONG on chromosome 2q33.1 confer risk of osteoporosis in Japanese. (PMID: 21573128) Kou I. … Ikegawa S. (PLoS ONE 2011) 2 3 4 67
  2. Association of the formiminotransferase N-terminal sub-domain containing gene and thrombospondin, type 1, domain-containing 7A gene with the prevalence of vertebral fracture in 2427 consecutive autopsy cases. (PMID: 23303384) Zhou H. … Ito H. (J. Hum. Genet. 2013) 3
  3. Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan. (PMID: 23648065) Low S.K. … Nakamura Y. (Cancer Sci. 2013) 3
  4. Genome-wide association analysis identifies 13 new risk loci for schizophrenia. (PMID: 23974872) Ripke S. … Sullivan P.F. (Nat. Genet. 2013) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for FTCDNL1 Gene

Sources for FTCDNL1 Gene

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