Aliases for FTCD Gene
External Ids for FTCD Gene
Previous GeneCards Identifiers for FTCD Gene
The protein encoded by this gene is a bifunctional enzyme that channels 1-carbon units from formiminoglutamate, a metabolite of the histidine degradation pathway, to the folate pool. Mutations in this gene are associated with glutamate formiminotransferase deficiency. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Dec 2009]
GeneCards Summary for FTCD Gene
FTCD (Formimidoyltransferase Cyclodeaminase) is a Protein Coding gene. Diseases associated with FTCD include Glutamate Formiminotransferase Deficiency and Autoimmune Hepatitis. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and One carbon pool by folate. GO annotations related to this gene include transferase activity and glutamate formimidoyltransferase activity. An important paralog of this gene is FTCDNL1.
UniProtKB/Swiss-Prot for FTCD Gene
Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.
Binds and promotes bundling of vimentin filaments originating from the Golgi.